SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Jay D. Horton, … , Joseph L. Goldstein, Michael S. Brown
Jay D. Horton, … , Joseph L. Goldstein, Michael S. Brown
Published May 1, 2002
Citation Information: J Clin Invest. 2002;109(9):1125-1131. https://doi.org/10.1172/JCI15593.
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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Abstract

Authors

Jay D. Horton, Joseph L. Goldstein, Michael S. Brown

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Genes regulated by SREBPs. The diagram shows the major metabolic interme...
Genes regulated by SREBPs. The diagram shows the major metabolic intermediates in the pathways for synthesis of cholesterol, fatty acids, and triglycerides. In vivo, SREBP-2 preferentially activates genes of cholesterol metabolism, whereas SREBP-1c preferentially activates genes of fatty acid and triglyceride metabolism. DHCR, 7-dehydrocholesterol reductase; FPP, farnesyl diphosphate; GPP, geranylgeranyl pyrophosphate synthase; CYP51, lanosterol 14α-demethylase; G6PD, glucose-6-phosphate dehydrogenase; PGDH, 6-phosphogluconate dehydrogenase; GPAT, glycerol-3-phosphate acyltransferase.