Osteoclasts are essential for TNF-α–mediated joint destruction
Kurt Redlich, … , Erwin F. Wagner, Georg Schett
Kurt Redlich, … , Erwin F. Wagner, Georg Schett
Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1419-1427. https://doi.org/10.1172/JCI15582.
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Article Immunology

Osteoclasts are essential for TNF-α–mediated joint destruction

Abstract

Research Article

Authors

Kurt Redlich, Silvia Hayer, Romeo Ricci, Jean-Pierre David, Makiyeh Tohidast-Akrad, George Kollias, Günter Steiner, Josef S. Smolen, Erwin F. Wagner, Georg Schett

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Figure 6

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Proteoglycan content is similarly reduced in cartilage of hTNFtg and c-f...
Proteoglycan content is similarly reduced in cartilage of hTNFtg and c-fos–/–hTNFtg mice. Toluidine blue staining of articular cartilage was performed in hTNFtg (a), c-fos–/–hTNFtg (b), wild-type (c), and c-fos–/– mice (d). A marked reduction of proteoglycan content indicated by decreased staining intensity (green arrows) was found in hTNFtg and c-fos–/–hTNFtg mice. Asterisks indicate the joint space. AC indicates articular cartilage. Magnification: ×200.