Osteoclasts are essential for TNF-α–mediated joint destruction
Kurt Redlich, … , Erwin F. Wagner, Georg Schett
Kurt Redlich, … , Erwin F. Wagner, Georg Schett
Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1419-1427. https://doi.org/10.1172/JCI15582.
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Article Immunology

Osteoclasts are essential for TNF-α–mediated joint destruction

Abstract

Research Article

Authors

Kurt Redlich, Silvia Hayer, Romeo Ricci, Jean-Pierre David, Makiyeh Tohidast-Akrad, George Kollias, Günter Steiner, Josef S. Smolen, Erwin F. Wagner, Georg Schett

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Figure 5

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Size of bone erosions is strongly correlated to number of osteoclasts. N...
Size of bone erosions is strongly correlated to number of osteoclasts. Numbers of osteoclasts assessed by histological quantification of TRAP-positive multinucleated cells in all joints at erosion sites are shown for wild-type, c-fos–/–, hTNFtg, and c-fos–/–hTNFtg mice (a). The areas of erosions given in mm2 were highly correlated to the numbers of osteoclasts per compartment (b).