Osteoclasts are essential for TNF-α–mediated joint destruction
Kurt Redlich, … , Erwin F. Wagner, Georg Schett
Kurt Redlich, … , Erwin F. Wagner, Georg Schett
Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1419-1427. https://doi.org/10.1172/JCI15582.
View: Text | PDF
Article Immunology

Osteoclasts are essential for TNF-α–mediated joint destruction

Abstract

Research Article

Authors

Kurt Redlich, Silvia Hayer, Romeo Ricci, Jean-Pierre David, Makiyeh Tohidast-Akrad, George Kollias, Günter Steiner, Josef S. Smolen, Erwin F. Wagner, Georg Schett

×

Figure 4

Options: View larger image (or click on image) Download as PowerPoint
There are abundant osteoclasts at the site of erosions in hTNFtg mice. H...
There are abundant osteoclasts at the site of erosions in hTNFtg mice. Histology of a proximal interphalangeal joint of an hTNFtg mouse is shown. Serial sections were stained with either H&E (a), TRAP (b and c), or calcitonin receptor (d). Inflammation (indicated by black arrows) with subsequent subchondral bone erosion (indicated by green arrows) was found only in hTNFtg mice (a). TRAP staining revealed a remarkable number of TRAP-positive multinucleated cells (black arrows) in hTNFtg mice at erosion sites (b and c). These TRAP-positive cells also showed positive staining for the calcitonin receptor (d). Magnification: a, ×100; b, ×200; c and d, ×400.