Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation
Augustus O. Grant, … , Carlo Napolitano, Silvia Priori
Augustus O. Grant, … , Carlo Napolitano, Silvia Priori
Published October 15, 2002
Citation Information: J Clin Invest. 2002;110(8):1201-1209. https://doi.org/10.1172/JCI15570.
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Article

Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation

Abstract

Research Article

Authors

Augustus O. Grant, Michael P. Carboni, Valentina Neplioueva, C. Frank Starmer, Mirella Memmi, Carlo Napolitano, Silvia Priori

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Inactivation and activation gating parameters in cells expressing the wi...
Inactivation and activation gating parameters in cells expressing the wild-type, ΔΚ1500, K1500E, and K1500Q mutant Na+ channels. Inactivation and activation were determined with standard voltage clamp protocols. The values for m∞ and h∞ are the means of 9, 13, 12, and 6 experiments for hH1, ΔΚ1500, Κ1500E, and K1500Q, respectively. V1/2m for hH1 was significantly different from V1/2m for K1500E and K1500Q. V1/2h for ΔΚ1500 was significantly different from V1/2h for hH1, K1500E, and K1500Q. The bars represent SEM.