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Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation
Augustus O. Grant, … , Carlo Napolitano, Silvia Priori
Augustus O. Grant, … , Carlo Napolitano, Silvia Priori
Published October 15, 2002
Citation Information: J Clin Invest. 2002;110(8):1201-1209. https://doi.org/10.1172/JCI15570.
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Article

Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation

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Abstract

Research Article

Authors

Augustus O. Grant, Michael P. Carboni, Valentina Neplioueva, C. Frank Starmer, Mirella Memmi, Carlo Napolitano, Silvia Priori

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Figure 5

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Voltage-dependence of Na+ channel inactivation. (a) Inactivation time co...
Voltage-dependence of Na+ channel inactivation. (a) Inactivation time constants were obtained with a protocol of conditioning and test pulses and plotted against conditioning voltage (n = 6–8 for hH1; n = 3–9 for ΔΚ1500). At potentials of –140, –120, and –100 mV, conditioning was effected by trains of twenty 40-ms pulses to –20 mV, followed by 20-ms test pulses. At potentials of –90, –80, –70, and –60 mV, a single conditioning pulse preceded each test pulse. (b) The relaxation phase of the Na+ current was fit with a single exponential function and plotted against the test potential (n = 10 for hH1; n = 11 for ΔΚ1500). Both measures show a reduction in the voltage-dependence of inactivation in the ΔΚ1500 mutant channels.

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