Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23
Edwin Liu, … , Fred D. Finkelman, George S. Eisenbarth
Edwin Liu, … , Fred D. Finkelman, George S. Eisenbarth
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):1021-1027. https://doi.org/10.1172/JCI15488.
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Article Immunology

Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23

Abstract

Research Article

Authors

Edwin Liu, Hiroaki Moriyama, Norio Abiru, Dongmei Miao, Liping Yu, Robert M. Taylor, Fred D. Finkelman, George S. Eisenbarth

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BALB/c mice recognize B:9-23 peptide and develop an IgG1 anti-peptide re...
BALB/c mice recognize B:9-23 peptide and develop an IgG1 anti-peptide response that is dose-dependent. Solid lines represent anti–B:9-23 antibodies in mice receiving repeated injections of B:9-23 at 100 μg/dose, whereas dashed lines represent mice receiving B:9-23 at 10 μg/dose. Serum was diluted at 1:500 for assay.