Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids
Florian P. Limbourg, … , Michael A. Moskowitz, James K. Liao
Florian P. Limbourg, … , Michael A. Moskowitz, James K. Liao
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1729-1738. https://doi.org/10.1172/JCI15481.
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Article Vascular biology

Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids

Abstract

Research Article

Authors

Florian P. Limbourg, Zhihong Huang, Jean-Christophe Plumier, Tommaso Simoncini, Masayuki Fujioka, Jan Tuckermann, Günther Schütz, Michael A. Moskowitz, James K. Liao

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Figure 2

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Regulation of CBF by corticosteroids.(a) Representative pseudocolor imag...
Regulation of CBF by corticosteroids.(a) Representative pseudocolor image of CBF ([14C]iodoantipyrine autoradiography) from coronal brain sections 1 hour after MCAo in mice treated with dexamethasone (20 mg/kg) or vehicle. (b) Regional changes in absolute CBF ([14C]iodoantipyrine) in ipsilateral and contralateral brain areas of mice treated with dexamethasone (20 mg/kg administered intraperitoneally) or vehicle (n = 10 per group). (c) Changes in absolute CBF in eNOS–/– mice were determined by the [14C]iodoamphetamine technique and expressed as percentages of contralateral CBF of vehicle-treated mice. *P < 0.05 vs. vehicle.