Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo
Stephan Fellner, … , Armin Buschauer, Gert Fricker
Stephan Fellner, … , Armin Buschauer, Gert Fricker
Published November 1, 2002
Citation Information: J Clin Invest. 2002;110(9):1309-1318. https://doi.org/10.1172/JCI15451.
View: Text | PDF
Article Oncology

Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

Abstract

Research Article

Authors

Stephan Fellner, Björn Bauer, David S. Miller, Martina Schaffrik, Martina Fankhänel, Thilo Spruß, Günther Bernhardt, Claudia Graeff, Lothar Färber, Harald Gschaidmeier, Armin Buschauer, Gert Fricker

×

Figure 3

Options: View larger image (or click on image) Download as PowerPoint
Increase of intracellular fluorescence intensity (free calcein) in monol...
Increase of intracellular fluorescence intensity (free calcein) in monolayers of porcine brain capillary endothelial cells. Presence of the p-gp substrates valspodar (filled circles) and paclitaxel (filled triangles) results in an increased fluorescence intensity, whereas penicillin (open circles) has no effect (means ± SEM, n = 6).