Increased C5a receptor expression in sepsis
Niels C. Riedemann, … , Firas S. Zetoune, Peter A. Ward
Niels C. Riedemann, … , Firas S. Zetoune, Peter A. Ward
Published July 1, 2002
Citation Information: J Clin Invest. 2002;110(1):101-108. https://doi.org/10.1172/JCI15409.
View: Text | PDF
Article Immunology

Increased C5a receptor expression in sepsis

Abstract

Research Article

Authors

Niels C. Riedemann, Ren-Feng Guo, Thomas A. Neff, Ines J. Laudes, Katie A. Keller, Vidya J. Sarma, Maciej M. Markiewski, Dimitrios Mastellos, Christoph W. Strey, Carl L. Pierson, John D. Lambris, Firas S. Zetoune, Peter A. Ward

×

Figure 7

Options: View larger image (or click on image) Download as PowerPoint
(a) ELISA measurements for IL-6 and TNF-α serum levels at 6 and 18 hours...
(a) ELISA measurements for IL-6 and TNF-α serum levels at 6 and 18 hours after CLP-induced sepsis and in healthy control mice (normal). When used, αC5aR treatment consisted of 20 μg/mouse at the start of CLP, with a companion group treated with control IgG (20 μg/mouse). (b) Content of aerobic bacteria in lung, liver, and kidney 18 hours after CLP-induced sepsis in mice. Compared groups were treated as described for a (n = 4 for all groups). *Statistically significant changes between αC5aR- and control IgG–treated CLP groups.