Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms
G. Matthew Longo, … , Nicola Fiotti, B. Timothy Baxter
G. Matthew Longo, … , Nicola Fiotti, B. Timothy Baxter
Published September 1, 2002
Citation Information: J Clin Invest. 2002;110(5):625-632. https://doi.org/10.1172/JCI15334.
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Article Vascular biology

Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms

Abstract

Research Article

Authors

G. Matthew Longo, Wanfen Xiong, Timothy C. Greiner, Yong Zhao, Nicola Fiotti, B. Timothy Baxter

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Figure 1

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The time course of expression of MMP-9 and MMP-2 and corresponding aneur...
The time course of expression of MMP-9 and MMP-2 and corresponding aneurysm growth. WT mouse aortae were incubated with CaCl2 or NaCl. Three days, 1 week, and 2, 3, and 4 weeks after treatment, the aortic diameters were measured and mice were sacrificed. (a) CaCl2-treated mice; (b) NaCl-treated mice (control). (c) Aortic diameter increases in CaCl2-treated mice at indicated time points. (d) H&E staining of CaCl2-treated mouse aortic section, showing a significant inflammatory infiltrate at 3 days.