Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms
G. Matthew Longo, Wanfen Xiong, Timothy C. Greiner, Yong Zhao, Nicola Fiotti, B. Timothy Baxter
G. Matthew Longo, Wanfen Xiong, Timothy C. Greiner, Yong Zhao, Nicola Fiotti, B. Timothy Baxter
View: Text | PDF
Article Vascular biology

Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms

Abstract

Research Article

Authors

G. Matthew Longo, Wanfen Xiong, Timothy C. Greiner, Yong Zhao, Nicola Fiotti, B. Timothy Baxter

×

Figure 1

Options: View larger image (or click on image) Download as PowerPoint
The time course of expression of MMP-9 and MMP-2 and corresponding aneur...
The time course of expression of MMP-9 and MMP-2 and corresponding aneurysm growth. WT mouse aortae were incubated with CaCl2 or NaCl. Three days, 1 week, and 2, 3, and 4 weeks after treatment, the aortic diameters were measured and mice were sacrificed. (a) CaCl2-treated mice; (b) NaCl-treated mice (control). (c) Aortic diameter increases in CaCl2-treated mice at indicated time points. (d) H&E staining of CaCl2-treated mouse aortic section, showing a significant inflammatory infiltrate at 3 days.