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1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
Yan Chun Li, … , Shu Q. Liu, Li-Ping Cao
Yan Chun Li, … , Shu Q. Liu, Li-Ping Cao
Published July 15, 2002
Citation Information: J Clin Invest. 2002;110(2):229-238. https://doi.org/10.1172/JCI15219.
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Article Article has an altmetric score of 30

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

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Abstract

Research Article

Authors

Yan Chun Li, Juan Kong, Minjie Wei, Zhou-Feng Chen, Shu Q. Liu, Li-Ping Cao

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Figure 5

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1,25-Dihydoxyvitamin D3 suppresses renin expression in wild-type mice. (...
1,25-Dihydoxyvitamin D3 suppresses renin expression in wild-type mice. (a) Wild-type mice (3 months old) were injected intraperitoneally with two or five doses of 30 pmol of 1,25(OH)2D3 (VD) dissolved in propylene glycol or vehicle (V). The two doses were given in 2 consecutive days at 9 am. The five doses were given in 3 consecutive days at 9 am and 7 pm on the first 2 days and 9 am on the third day. Total renal RNA was isolated 6 hours after the last injection. Renin, calbindin-D9k (CaBP-D9k), and 36B4 mRNA levels were determined by Northern blot analysis. (b) Quantitation of renin mRNA levels. Black bars, vehicle treatment; white bars, 1,25(OH)2D3 treatment. *P < 0.05 vs. vehicle treatment; n ≥ 3 in each group.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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