Histological examination of atherosclerotic lesions in the aortic root. (a and b) Photographs are representative of immunostaining for MOMA-2 in the atherosclerotic lesions, which showed no difference in the distribution between apoE-KO (a) and apoE-KO/eNOS-Tg mice (b) fed on a high-cholesterol diet for 8 weeks. (c and d) Fibrotic changes were detected with Masson’s trichrome in the aortic root sections from apoE-KO (c) and apoE-KO/eNOS-Tg mice (d) fed a high-cholesterol diet. Fibrosis was only partly distributed in the plaque lesions of both mice (original magnification ×75).