Absence of angiotensin II type 1 receptor in bone marrow–derived cells is detrimental in the evolution of renal fibrosis
Masashi Nishida, … , Hiroaki Yoshida, Iekuni Ichikawa
Masashi Nishida, … , Hiroaki Yoshida, Iekuni Ichikawa
Published December 15, 2002
Citation Information: J Clin Invest. 2002;110(12):1859-1868. https://doi.org/10.1172/JCI15045.
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Article

Absence of angiotensin II type 1 receptor in bone marrow–derived cells is detrimental in the evolution of renal fibrosis

Abstract

Research Article

Authors

Masashi Nishida, Hidehiko Fujinaka, Taiji Matsusaka, James Price, Valentina Kon, Agnes B. Fogo, Jeffrey M. Davidson, MacRae F. Linton, Sergio Fazio, Toshio Homma, Hiroaki Yoshida, Iekuni Ichikawa

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mRNA expressions of molecules involved in the accumulation of ECM. (a) N...
mRNA expressions of molecules involved in the accumulation of ECM. (a) Northern blot analyses of TGF-β1 expressions at day 5 (left) and day 14 (right) after UUO in wild-type mice with Agtr1–/– marrow and wild-type mice with Agtr1+/+ marrow. (b and c) Northern blot analyses of α1(I) collagen, MMP-2, and TIMP-1 at day 5 (b) and day 14 (c) after UUO. Lane 1 in (b) and (c) shows control contralateral nonobstructed kidney, lane 2 shows mice with Agtr1–/– marrow, and lane 3 shows mice with Agtr1+/+ marrow.