Absence of angiotensin II type 1 receptor in bone marrow–derived cells is detrimental in the evolution of renal fibrosis
Masashi Nishida, … , Hiroaki Yoshida, Iekuni Ichikawa
Masashi Nishida, … , Hiroaki Yoshida, Iekuni Ichikawa
Published December 15, 2002
Citation Information: J Clin Invest. 2002;110(12):1859-1868. https://doi.org/10.1172/JCI15045.
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Article

Absence of angiotensin II type 1 receptor in bone marrow–derived cells is detrimental in the evolution of renal fibrosis

Abstract

Research Article

Authors

Masashi Nishida, Hidehiko Fujinaka, Taiji Matsusaka, James Price, Valentina Kon, Agnes B. Fogo, Jeffrey M. Davidson, MacRae F. Linton, Sergio Fazio, Toshio Homma, Hiroaki Yoshida, Iekuni Ichikawa

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Quantitative analyses of interstitial collagens after UUO in wild-type m...
Quantitative analyses of interstitial collagens after UUO in wild-type mice with either Agtr1–/– marrow or Agtr1+/+ marrow. (a) Interstitial collagen index assessed by point-counting method on Masson trichrome–stained sections at day 5 (left) and day 14 (right) after UUO. (b) Collagen content as percentage of total protein in kidney at day 14 after UUO. Black bars represent mice with Agtr1–/– marrow; white bars represent mice with Agtr1+/+ marrow. Data are expressed as means ± SEM.*P < 0.005 for mice with Agtr1–/– marrow versus mice with Agtr1+/+ marrow.