Absence of angiotensin II type 1 receptor in bone marrow–derived cells is detrimental in the evolution of renal fibrosis
Masashi Nishida, … , Hiroaki Yoshida, Iekuni Ichikawa
Masashi Nishida, … , Hiroaki Yoshida, Iekuni Ichikawa
Published December 15, 2002
Citation Information: J Clin Invest. 2002;110(12):1859-1868. https://doi.org/10.1172/JCI15045.
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Article

Absence of angiotensin II type 1 receptor in bone marrow–derived cells is detrimental in the evolution of renal fibrosis

Abstract

Research Article

Authors

Masashi Nishida, Hidehiko Fujinaka, Taiji Matsusaka, James Price, Valentina Kon, Agnes B. Fogo, Jeffrey M. Davidson, MacRae F. Linton, Sergio Fazio, Toshio Homma, Hiroaki Yoshida, Iekuni Ichikawa

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Figure 3

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Histological assessment of interstitial fibrosis and peritubular capilla...
Histological assessment of interstitial fibrosis and peritubular capillary density and detection of myofibroblasts in the obstructed kidneys of wild-type mice with either Agtr1–/– marrow or Agtr1+/+ marrow. Masson trichrome staining of the renal cortex at day 14 after UUO (a), immunohistochemical assessment of peritubular capillary density by immunostaining with anti-CD31 antibody at day 5 after UUO (b), and detection of myofibroblasts by immunostaining with anti-αSMA antibody at day14 after UUO (c) in mice with Agtr1–/– marrow (left) and mice with Agtr1+/+ marrow (right). Magnification, ×400.