JCI - Heparin’s anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins

Heparin’s anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins

Lianchun Wang, … , Ajit Varki, Jeffrey D. Esko

Published July 1, 2002
Citation Information: J Clin Invest. 2002;110(1):127-136. https://doi.org/10.1172/JCI14996.

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Effects of heparinoids on selectin-dependent cell adhesion. Adhesion of U937 cells to immobilized selectin-Ig chimeras was measured (see Methods). Inclusion of a mAb to P-selectin, E-selectin, or EDTA blocked binding by more than 90%. Each point represents the average of duplicate determinations, and the data are representative of three or four separate experiments.

Heparin’s anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins

Heparin’s anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins

Abstract

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