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Research Article Free access | 10.1172/JCI1486

Regulation of experimental autoimmune encephalomyelitis with insulin-like growth factor (IGF-1) and IGF-1/IGF-binding protein-3 complex (IGF-1/IGFBP3).

A E Lovett-Racke, P Bittner, A H Cross, J A Carlino, and M K Racke

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Find articles by Lovett-Racke, A. in: JCI | PubMed | Google Scholar

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Find articles by Racke, M. in: JCI | PubMed | Google Scholar

Published April 15, 1998 - More info

Published in Volume 101, Issue 8 on April 15, 1998
J Clin Invest. 1998;101(8):1797–1804. https://doi.org/10.1172/JCI1486.
© 1998 The American Society for Clinical Investigation
Published April 15, 1998 - Version history
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Abstract

Insulin-like growth factor (IGF)-1 is a cytokine that promotes oligodendrocyte development and myelin production. This study investigated whether treatment of chronic, relapsing murine experimental autoimmune encephalomyelitis (EAE) with IGF-1 or IGF-1 associated with its binding protein, IGFBP3, altered the course of disease. Administration of IGF-1/IGFBP3 (1-100 mg/kg per day) delayed the onset of disease in a dose-dependent manner and histologic examination showed a delay in inflammatory cells entering the central nervous system. However, once signs of EAE developed, disease was enhanced in the mice that had been given the highest dose of IGF-1/IGFBP3. Treatment with IGF-1/IGFBP3 after the onset of signs resulted in a severe relapse. Administration of free IGF-1 (10 mg/kg per day) provided mild protection when given before disease onset, but did not significantly alter the course of disease if given after disease onset. Possible mechanisms that could explain the altered disease in IGF-1/IGFBP3-treated mice included (a) IGF-1/IGFBP3 administration delayed the onset of EAE by downregulating ICAM-1 gene expression in the central nervous system, and (b) IGF-1/IGFBP3 treatment of EAE resulted in more severe disease due to enhanced expansion of encephalitogenic T cells. Although IGF-1 may enhance remyelination, these results indicate that administration of IGF-1 associated with IGFBP3 may also accentuate autoimmune demyelinating disease.

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