Lewis lung tumor model: mecamylamine inhibits advanced tumor growth. Two weeks after subcutaneous injection of Lewis lung cancer cells, tumor growth was similar in the control and mecamylamine groups. In the subsequent study period, however, animals treated with mecamylamine showed significantly less tumor growth. Data are median (95% CI); n = 5; P < 0.01 compared with control at 24 days. Tumor vascularity was suppressed by mecamylamine (data not shown).