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Hassen Kared, … , Aaron A.R. Tobian, Thomas C. Quinn
Published January 11, 2021
Citation Information: J Clin Invest. 2021;131(5):e145476. https://doi.org/10.1172/JCI145476.
Citation Information: J Clin Invest. 2021;131(5):e145476. https://doi.org/10.1172/JCI145476.
Abstract
Characterization of the T cell response in individuals who recover from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical to understanding its contribution to protective immunity. A multiplexed peptide-MHC tetramer approach was used to screen 408 SARS-CoV-2 candidate epitopes for CD8+ T cell recognition in a cross-sectional sample of 30 coronavirus disease 2019 convalescent individuals. T cells were evaluated using a 28-marker phenotypic panel, and findings were modelled against time from diagnosis and from humoral and inflammatory responses. There were 132 SARS-CoV-2–specific CD8+ T cell responses detected across 6 different HLAs, corresponding to 52 unique epitope reactivities. CD8+ T cell responses were detected in almost all convalescent individuals and were directed against several structural and nonstructural target epitopes from the entire SARS-CoV-2 proteome. A unique phenotype for SARS-CoV-2–specific T cells was observed that was distinct from other common virus-specific T cells detected in the same cross-sectional sample and characterized by early differentiation kinetics. Modelling demonstrated a coordinated and dynamic immune response characterized by a decrease in inflammation, increase in neutralizing antibody titer, and differentiation of a specific CD8+ T cell response. Overall, T cells exhibited distinct differentiation into stem cell and transitional memory states (subsets), which may be key to developing durable protection.
Authors
Hassen Kared, Andrew D. Redd, Evan M. Bloch, Tania S. Bonny, Hermi Sumatoh, Faris Kairi, Daniel Carbajo, Brian Abel, Evan W. Newell, Maria P. Bettinotti, Sarah E. Benner, Eshan U. Patel, Kirsten Littlefield, Oliver Laeyendecker, Shmuel Shoham, David Sullivan, Arturo Casadevall, Andrew Pekosz, Alessandra Nardin, Michael Fehlings, Aaron A.R. Tobian, Thomas C. Quinn
Citation information
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Pitiriga VC, Papamentzelopoulou M, Konstantinakou KE, Vasileiou IV, Sakellariou KS, Spyrou NI, Tsakris A |
Human vaccines | 2023 |
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Harnessing SARS‐CoV‐2‐specific CD8+ T cells to kill target tumor cells for cancer immunotherapy
Jung K, Ko D, Jang J, Kim YR, Heo JY, Kim Y |
2023 | |
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The HLA-II immunopeptidome of SARS-CoV-2
Weingarten-Gabbay S, Chen DY, Sarkizova S, Taylor HB, Gentili M, Hernandez GM, Pearlman LR, Bauer MR, Rice CM, Clauser KR, Hacohen N, Carr SA, Abelin JG, Saeed M, Sabeti PC |
Cell Reports | 2023 |
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Perturbations of the T-cell receptor repertoire in response to SARS-CoV-2 in immunocompetent and immunocompromised individuals
Delmonte OM, Oguz C, Dobbs K, Myint-Hpu K, Palterer B, Abers MS, Draper D, Truong M, Kaplan IM, Gittelman RM, Zhang Y, Rosen LB, Snow AL, Dalgard CL, Burbelo PD, Imberti L, Sottini A, Quiros-Roldan E, Castelli F, Rossi C, Brugnoni D, Biondi A, Bettini LR, D\u2019Angio\u2019 M, Bonfanti P, Anderson MV, Saracino A, Chironna M, Di Stefano M, Fiore JR, Santantonio T, Castagnoli R, Marseglia GL, Magliocco M, Bosticardo M, Pala F, Shaw E, Matthews H, Weber SE, Xirasagar S, Barnett J, Oler AJ, Dimitrova D, Bergerson JR, McDermott DH, Rao VK, Murphy PM, Holland SM, Lisco A, Su HC, Lionakis MS, Cohen JI, Freeman AF, Snyder TM, Lack J, Notarangelo LD |
Journal of Allergy and Clinical Immunology | 2023 |
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Multiple sclerosis therapies differentially impact SARS-CoV-2 vaccine-induced antibody and T cell immunity and function
Joseph Sabatino, Kristen Mittl, William M Rowles, Kira McPolin, Jayant V Rajan, Matthew T. Laurie, Colin R Zamecnik, Ravi Dandekar, Bonny D. Alvarenga, Rita P. Loudermilk, Chloe Gerungan, Collin M. Spencer, Sharon Sagan, Danillo G. Augusto, Jessa R Alexander, Joseph DeRisi, Jill A. Hollenbach, Michael R. Wilson, Scott S. Zamvil, Riley Bove |
JCI Insight | 2022 |
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Immunogenic epitope panel for accurate detection of non-cross-reactive T cell response to SARS-CoV-2
Aleksei Titov, Regina Shaykhutdinova, Olga Shcherbakova, Yana Serdyuk, Savely Sheetikov, Ksenia V. Zornikova, Alexandra V. Maleeva, Alexandra Khmelevskaya, Dmitry V. Dianov, Naina T. Shakirova, Dmitry B. Malko, Maxim Shkurnikov, Stepan Nersisyan, Alexander Tonevitsky, Ekaterina Khamaganova, Anton V. Ershov, Elena Osipova, Ruslan Nikolaev, Dmitry Pershin, Viktoria A. Vedmedskia, Michael Maschan, Victoria R. Ginanova, Grigory A. Efimov |
JCI Insight | 2022 |
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Dominant CD8+ T Cell Nucleocapsid Targeting in SARS-CoV-2 Infection and Broad Spike Targeting From Vaccination
E Taus, C Hofmann, F Ibarrondo, M Hausner, J Fulcher, P Krogstad, K Ferbas, N Tobin, A Rimoin, G Aldrovandi, O Yang |
Frontiers in immunology | 2022 |
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CD8+ T Cells in SARS-CoV-2 Induced Disease and Cancer—Clinical Perspectives
K Mortezaee, J Majidpoor |
Frontiers in immunology | 2022 |
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COVID-19 pandemic: the delta variant, T-cell responses, and the efficacy of developing vaccines
B Biswas, S Chattopadhyay, S Hazra, A Hansda, R Goswami |
Inflammation Research | 2022 |
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Prevalence of COVID-19-associated symptoms during acute infection in relation to SARS-CoV-2-directed humoral and cellular immune responses in a mild-diseased convalescent cohort
C Tegeler, T Bilich, Y Maringer, H Salih, J Walz, A Nelde, J Heitmann |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases | 2022 |
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Minimal Crossover between Mutations Associated with Omicron Variant of SARS-CoV-2 and CD8 + T-Cell Epitopes Identified in COVID-19 Convalescent Individuals
A Redd, A Nardin, H Kared, E Bloch, B Abel, A Pekosz, O Laeyendecker, M Fehlings, T Quinn, A Tobian, S Goff |
mBio | 2022 |
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Large-Scale Structure-Based Screening of Potential T Cell Cross-Reactivities Involving Peptide-Targets From BCG Vaccine and SARS-CoV-2
R Tarabini, M Rigo, A Fonseca, F Rubin, R Bellé, L Kavraki, T Ferreto, D Antunes, A de Souza |
Frontiers in immunology | 2022 |
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Decline of Humoral and Cellular Immune Responses Against SARS-CoV-2 6 Months After Full BNT162b2 Vaccination in Hospital Healthcare Workers
B Bonnet, H Chabrolles, C Archimbaud, A Brebion, J Cosme, F Dutheil, C Lambert, M Junda, A Mirand, A Ollier, B Pereira, C Regagnon, M Vidal, B Evrard, C Henquell |
Frontiers in immunology | 2022 |
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Time-dependent contraction of the SARS-CoV-2–specific T-cell responses in convalescent individuals
Fernandes ER, de Souza Apostolico J, Jacintho LC, Carnevale Marin ML, Vieira da Silva Júnior RC, Rodrigues H, Santos KS, Coelho V, Boscardin SB, Kalil J, Cunha-Neto E, Rosa DS |
2022 | |
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Prediction of SARS-CoV-2 Omicron Variant Immunogenicity, Immune Escape and Pathogenicity, through the Analysis of Spike Protein-Specific Core Unique Peptides.
Kontopodis E, Pierros V, Stravopodis DJ, Tsangaris GT |
Human vaccines | 2022 |
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Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors
Wu D, Kolesnikov A, Yin R, Guest JD, Gowthaman R, Shmelev A, Serdyuk Y, Dianov DV, Efimov GA, Pierce BG, Mariuzza RA |
Nature Communications | 2022 |
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Unique peptide signatures of SARS-CοV-2 virus against human proteome reveal variants’ immune escape and infectiveness
Pierros V, Kontopodis E, Stravopodis DJ, Tsangaris GT |
Heliyon | 2022 |
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SARS-CoV-2-specific T-cell epitope repertoire in convalescent and mRNA-vaccinated individuals
Lang-Meli J, Luxenburger H, Wild K, Karl V, Oberhardt V, Salimi Alizei E, Graeser A, Reinscheid M, Roehlen N, Reeg DB, Giese S, Ciminski K, Götz V, August D, Rieg S, Waller CF, Wengenmayer T, Staudacher D, Huzly D, Bengsch B, Kochs G, Schwemmle M, Emmerich F, Boettler T, Thimme R, Hofmann M, Neumann-Haefelin C |
Nature Microbiology | 2022 |
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Vaccine-induced systemic and mucosal T cell immunity to SARS-CoV-2 viral variants
Kingstad-Bakke B, Lee W, Chandrasekar SS, Gasper DJ, Salas-Quinchucua C, Cleven T, Sullivan JA, Talaat A, Osorio JE, Suresh M |
Proceedings of the National Academy of Sciences | 2022 |
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Immunosuppressant Treatment in Rheumatic Musculoskeletal Diseases Does Not Inhibit Elicitation of Humoral Response to SARS-CoV-2 Infection and Preserves Effector Immune Cell Populations
Favalli A, Favalli EG, Gobbini A, Zagato E, Bombaci M, Maioli G, Pesce E, Donnici L, Gruarin P, Biggioggero M, Curti S, Manganaro L, Marchisio E, Bevilacqua V, Martinovic M, Fabbris T, Sarnicola ML, Crosti M, Marongiu L, Granucci F, Notarbartolo S, Bandera A, Gori A, De Francesco R, Abrignani S, Caporali R, Grifantini R |
Frontiers in immunology | 2022 |
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High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4+ T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19
Cords L, Knapp M, Woost R, Schulte S, Kummer S, Ackermann C, Beisel C, Peine S, Johansson AM, Kwok WW, Günther T, Fischer N, Wittner M, Addo MM, Huber S, Schulze zur Wiesch J |
Viruses | 2022 |
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DNA Vaccines Expressing the Envelope and Membrane Proteins Provide Partial Protection Against SARS-CoV-2 in Mice.
Chen J, Deng Y, Huang B, Han D, Wang W, Huang M, Zhai C, Zhao Z, Yang R, Zhao Y, Wang W, Zhai D, Tan W |
Frontiers in immunology | 2022 |
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Swine Enteric Coronaviruses (PEDV, TGEV, and PDCoV) Induce Divergent Interferon-Stimulated Gene Responses and Antigen Presentation in Porcine Intestinal Enteroids
Yin L, Liu X, Hu D, Luo Y, Zhang G, Liu P |
Frontiers in immunology | 2022 |
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In silico analysis of mutant epitopes in new SARS-CoV-2 lineages suggest global enhanced CD8+ T cell reactivity and also signs of immune response escape
Pretti MA, Galvani RG, Scherer NM, Farias AS, Boroni M |
Infection, Genetics and Evolution | 2022 |
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Mutational Pattern, Impacts and Potential Preventive Strategies of Omicron SARS-CoV-2 Variant Infection
Chekol Abebe E, Tiruneh G\/Medhin M, Behaile T\/Mariam A, Asmamaw Dejenie T, Mengie Ayele T, Tadele Admasu F, Tilahun Muche Z, Asmare Adela G |
Infection and drug resistance | 2022 |
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Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID
Krishna BA, Lim EY, Mactavous L, Lyons PA, Doffinger R, Bradley JR, Smith KG, Sinclair J, Matheson NJ, Lehner PJ, Wills MR, Sithole N |
EBioMedicine | 2022 |
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Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine.
Liu Y, Zeng Q, Deng C, Li M, Li L, Liu D, Liu M, Ruan X, Mei J, Mo R, Zhou Q, Liu M, Peng S, Wang J, Zhang H, Xiao H |
Cell Discovery | 2022 |
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Endothelial Biomarkers in Patients Recovered from COVID-19 One Year after Hospital Discharge: A Cross-Sectional Study
Tong M, Yan X, Jiang Y, Jin Z, Zhu S, Zou L, Liu Y, Zheng Q, Chen G, Gu R, Zhou Z, Han X, He J, Yin S, Ma C, Xiao W, Zeng Y, Chen F, Zhu Y |
Mediterranean journal of hematology and infectious diseases | 2022 |
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Comparing the Nucleocapsid Proteins of Human Coronaviruses: Structure, Immunoregulation, Vaccine, and Targeted Drug
Zhang B, Tian J, Zhang Q, Xie Y, Wang K, Qiu S, Lu K, Liu Y |
Frontiers in Molecular Biosciences | 2022 |
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SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 T cells
Minervina AA, Pogorelyy MV, Kirk AM, Crawford JC, Allen EK, Chou CH, Mettelman RC, Allison KJ, Lin CY, Brice DC, Zhu X, Vegesana K, Wu G, Trivedi S, Kottapalli P, Darnell D, McNeely S, Olsen SR, Schultz-Cherry S, Estepp JH, McGargill MA, Wolf J, Thomas PG |
Nature Immunology | 2022 |
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Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses
Lyudovyk O, Kim JY, Qualls D, Hwee MA, Lin YH, Boutemine SR, Elhanati Y, Solovyov A, Douglas M, Chen E, Babady NE, Ramanathan L, Vedantam P, Bandlamudi C, Gouma S, Wong P, Hensley SE, Greenbaum B, Huang AC, Vardhana SA |
Cancer Cell | 2022 |
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Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose.
Renia L, Goh YS, Rouers A, Le Bert N, Chia WN, Chavatte JM, Fong SW, Chang ZW, Zhuo NZ, Tay MZ, Chan YH, Tan CW, Yeo NK, Amrun SN, Huang Y, Wong JXE, Hor PX, Loh CY, Wang B, Ngoh EZX, Salleh SNM, Carissimo G, Dowla S, Lim AJ, Zhang J, Lim JME, Wang CI, Ding Y, Pada S, Sun LJ, Somani J, Lee ES, Ong DLS, Leo YS, MacAry PA, Lin RTP, Wang LF, Ren EC, Lye DC, Bertoletti A, Young BE, Ng LFP |
Nature Communications | 2022 |
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Individuals With Higher CD4/CD8 Ratio Exhibit Increased Risk of Acute Respiratory Distress Syndrome and In-Hospital Mortality During Acute SARS-CoV-2 Infection
Pascual-Dapena A, Chillaron JJ, Llauradó G, Arnau-Barres I, Flores J, Lopez-Montesinos I, Sorlí L, Luis Martínez-Pérez J, Gómez-Zorrilla S, Du J, García-Giralt N, Güerri-Fernández R |
Frontiers in Medicine | 2022 |
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Omicron BA.1 Mutations in SARS-CoV-2 Spike Lead to Reduced T-Cell Response in Vaccinated and Convalescent Individuals
Emmelot ME, Vos M, Boer MC, Rots NY, de Wit J, van Els CA, Kaaijk P |
Viruses | 2022 |
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A single immunization with cellular vaccine confers dual protection against SARS‐CoV‐2 and cancer
Shimizu K, Ueda S, Kawamura M, Satoh M, Fujii S |
Cancer Science | 2022 |
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T cell perturbations persist for at least 6 months following hospitalization for COVID-19
Govender M, Hopkins FR, Göransson R, Svanberg C, Shankar EM, Hjorth M, Nilsdotter-Augustinsson Å, Sjöwall J, Nyström S, Larsson M |
Frontiers in immunology | 2022 |
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Effects of nutrients on immunomodulation in patients with severe COVID-19: Current knowledge
da Costa BT, Araújo GR, da Silva Júnior RT, Santos LK, Lima de Souza Gonçalves V, Lima DB, Cuzzuol BR, Santos Apolonio J, de Carvalho LS, Marques HS, Silva CS, Barcelos ID, Oliveira MV, Freire de Melo F |
World Journal of Critical Care Medicine | 2022 |
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Clinical and immunological features associated to the development of a sustained immune humoral response in COVID-19 patients: Results from a cohort study
Torres-Ruiz J, Lomelín-Gascón J, Vargas-Castro AS, Lira-Luna J, Pérez-Fragoso A, Tapia-Conyer R, Nuñez-Aguirre M, Alcalá-Carmona B, Absalón-Aguilar A, Maravillas-Montero JL, Mejía-Domínguez NR, Núñez-Álvarez C, Rull-Gabayet M, Llorente L, Romero-Ramírez S, Sosa-Hernández VA, Cervantes-Díaz R, Juárez-Vega G, Meza-Sánchez DE, Martínez-Juárez LA, Morales-Juárez L, López-López LN, Negrete-Trujillo JA, Falcón-Lezama JA, Valdez-Vázquez RR, Gallardo-Rincón H, Gómez-Martín D |
Frontiers in immunology | 2022 |
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The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization
Karger AB, Brien JD, Christen JM, Dhakal S, Kemp TJ, Klein SL, Pinto LA, Premkumar L, Roback JD, Binder RA, Boehme KW, Boppana S, Cordon-Cardo C, Crawford JM, Daiss JL, Dupuis AP II, Espino AM, Firpo-Betancourt A, Forconi C, Forrest JC, Girardin RC, Granger DA, Granger SW, Haddad NS, Heaney CD, Hunt DT, Kennedy JL, King CL, Krammer F, Kruczynski K, LaBaer J, Lee FE, Lee WT, Liu SL, Lozanski G, Lucas T, Mendu DR, Moormann AM, Murugan V, Okoye NC, Pantoja P, Payne AF, Park J, Pinninti S, Pinto AK, Pisanic N, Qiu J, Sariol CA, Simon V, Song L, Steffen TL, Stone ET, Styer LM, Suthar MS, Thomas SN, Thyagarajan B, Wajnberg A, Yates JL, Sobhani K |
mSphere | 2022 |
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HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2
Olafsdottir TA, Bjarnadottir K, Norddahl GL, Halldorsson GH, Melsted P, Gunnarsdottir K, Ivarsdottir E, Olafsdottir T, Arnthorsson AO, Theodors F, Eythorsson E, Helgason D, Eggertsson HP, Masson G, Bjarnadottir S, Saevarsdottir S, Runolfsdottir HL, Olafsson I, Saemundsdottir J, Sigurdsson MI, Ingvarsson RF, Palsson R, Thorgeirsson G, Halldorsson BV, Holm H, Kristjansson M, Sulem P, Thorsteinsdottir U, Jonsdottir I, Gudbjartsson DF, Stefansson K |
2022 | |
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Long-term memory CD8+ T cells specific for SARS-CoV-2 in individuals who received the BNT162b2 mRNA vaccine
Kuse N, Zhang Y, Chikata T, Nguyen HT, Oka S, Gatanaga H, Takiguchi M |
Nature Communications | 2022 |
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The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognition.
Motozono C, Toyoda M, Tan TS, Hamana H, Goto Y, Aritsu Y, Miyashita Y, Oshiumi H, Nakamura K, Okada S, Udaka K, Kitamatsu M, Kishi H, Ueno T |
Nature Communications | 2022 |
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Improving MHC class I antigen-processing predictions using representation learning and cleavage site-specific kernels
Lawrence PJ, Ning X |
2022 | |
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Identification and assessment of TCR-T cells targeting an epitope conserved in SARS-CoV-2 variants for the treatment of COVID-19
Ma Y, Liu F, Li B, Peng K, Zhou H, Xu Y, Qiao D, Deng L, Tian G, Nielsen M, Wang M |
International Immunopharmacology | 2022 |
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Acriflavine and proflavine hemisulfate as potential antivirals by targeting Mpro
Liang J, Zheng M, Xu W, Chen Y, Tang P, Wu G, Zou P, Li H, Chen L |
Bioorganic chemistry | 2022 |
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Parallel detection of SARS‐CoV‐2 epitopes reveals dynamic immunodominance profiles of CD8 + T memory cells in convalescent COVID‐19 donors
van den Dijssel J, Hagen RR, de Jongh R, Steenhuis M, Rispens T, Geerdes DM, Mok JY, Kragten AH, Duurland MC, Verstegen NJ, van Ham SM, van Esch WJ, van Gisbergen KP, Hombrink P, ten Brinke A, van de Sandt CE |
IBMS BoneKEy | 2022 |
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Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike.
Tan TS, Toyoda M, Ode H, Barabona G, Hamana H, Kitamatsu M, Kishi H, Motozono C, Iwatani Y, Ueno T |
Journal of virology | 2022 |
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Ablation of CD8+ T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA.1, BA.2 and BA.3.
Swaminathan S, Lineburg KE, Panikkar A, Raju J, Murdolo LD, Szeto C, Crooks P, Le Texier L, Rehan S, Dewar-Oldis MJ, Barnard PJ, Ambalathingal GR, Neller MA, Short KR, Gras S, Khanna R, Smith C |
Nature Communications | 2022 |
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Bioinformatic and Experimental Analysis of T Cell Immune Reactivity to SARS-CoV-2 and its Variants.
Tarke A, Grifoni A, Sette A |
2022 | |
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Genetic regulation of iron homeostasis in sideropenic patients with mild COVID-19 disease under a new oral iron formulation: Lessons from a different perspective
Giordano G, Teresa Bochicchio M, Niro G, Lucchesi A, Napolitano M |
Immunobiology | 2022 |
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Protection from COVID-19 with a VSV-based vaccine expressing the spike and nucleocapsid proteins
O\u2019Donnell KL, Gourdine T, Fletcher P, Clancy CS, Marzi A |
Frontiers in immunology | 2022 |
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SARS-CoV-2—The Role of Natural Immunity: A Narrative Review
Diani S, Leonardi E, Cavezzi A, Ferrari S, Iacono O, Limoli A, Bouslenko Z, Natalini D, Conti S, Mantovani M, Tramonte S, Donzelli A, Serravalle E |
Journal of Clinical Medicine | 2022 |
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Emerging Effects of IL-33 on COVID-19
Gao Y, Cai L, Li L, Zhang Y, Li J, Luo C, Wang Y, Tao L |
International journal of molecular sciences | 2022 |
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High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection
Jacobsen EM, Fabricius D, Class M, Topfstedt F, Lorenzetti R, Janowska I, Schmidt F, Staniek J, Zernickel M, Stamminger T, Dietz AN, Zellmer A, Hecht M, Rauch P, Blum C, Ludwig C, Jahrsdörfer B, Schrezenmeier H, Heeg M, Mayer B, Seidel A, Groß R, Münch J, Kirchhoff F, Bode SF, Strauss G, Renk H, Elling R, Stich M, Voll RE, Tönshof B, Franz AR, Henneke P, Debatin KM, Rizzi M, Janda A |
Nature Communications | 2022 |
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Association of cellular immunity with severity of COVID-19 from the perspective of antigen-specific memory T cell responses and cross-reactivity
Fujii SI, Yamasaki S, Iyoda T, Shimizu K |
Ensho Saisei | 2022 |
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Clonal diversity predicts persistence of SARS-CoV-2 epitope-specific T-cell response
Zornikova KV, Khmelevskaya A, Sheetikov SA, Kiryukhin DO, Shcherbakova OV, Titov A, Zvyagin IV, Efimov GA |
Communications biology | 2022 |
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Large libraries of single-chain trimer peptide-MHCs enable rapid antigen-specific CD8+ T cell discovery and analysis
Heath J, Chour W, Choi J, Xie J, Chaffee M, Schmitt T, Finton K, Delucia D, Xu A, Su Y, Chen D, Zhang R, Yuan D, Hong S, Ng A, Butler J, Edmark R, Jones L, Murray K, Peng S, Li G, Strong R, Lee J, Goldman J, Greenberg P |
Research square | 2022 |
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A systemic review of T-cell epitopes defined from the proteome of SARS-CoV-2
Jin X, Liu X, Shen C |
Virus Research | 2022 |
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Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19
Ogura H, Gohda J, Lu X, Yamamoto M, Takesue Y, Son A, Doi S, Matsushita K, Isobe F, Fukuda Y, Huang TP, Ueno T, Mambo N, Murakami H, Kawaguchi Y, Inoue JI, Shirai K, Yamasaki S, Hirata JI, Ishido S |
Nature Communications | 2022 |
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Absence of pathogenic viruses in COVID-19 convalescent plasma.
Kandathil AJ, Benner SE, Bloch EM, Shrestha R, Ajayi O, Zhu X, Caturegli PP, Shoham S, Sullivan D, Gebo K, Quinn TC, Casadevall A, Hanley D, Pekosz A, Redd AD, Balagopal A, Tobian AAR |
Transfusion | 2022 |
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The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization.
Karger AB, Brien JD, Christen JM, Dhakal S, Kemp TJ, Klein SL, Pinto LA, Premkumar L, Roback JD, Binder RA, Boehme KW, Boppana S, Cordon-Cardo C, Crawford JM, Daiss JL, Dupuis AP 2nd, Espino AM, Firpo-Betancourt A, Forconi C, Forrest JC, Girardin RC, Granger DA, Granger SW, Haddad NS, Heaney CD, Hunt DT, Kennedy JL, King CL, Krammer F, Kruczynski K, LaBaer J, Lee FE, Lee WT, Liu SL, Lozanski G, Lucas T, Mendu DR, Moormann AM, Murugan V, Okoye NC, Pantoja P, Payne AF, Park J, Pinninti S, Pinto AK, Pisanic N, Qiu J, Sariol CA, Simon V, Song L, Steffen TL, Stone ET, Styer LM, Suthar MS, Thomas SN, Thyagarajan B, Wajnberg A, Yates JL, Sobhani K |
medRxiv : the preprint server for health sciences | 2022 |
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SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 T cells
Minervina AA, Pogorelyy MV, Kirk AM, Crawford JC, Allen EK, Chou CH, Mettelman RC, Allison KJ, Lin CY, Brice DC, Zhu X, Vegesana K, Wu G, Trivedi S, Kottapalli P, Darnell D, McNeely S, Olsen SR, Schultz-Cherry S, Estepp JH, McGargill MA, Wolf J, Thomas PG |
2022 | |
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Duration of post-COVID-19 symptoms are associated with sustained SARS-CoV-2 specific immune responses
Jacob K Files, Sanghita Sarkar, Timothy R Fram, Sushma Boppana, Sarah Sterrett, Kai Qin, Anju Bansal, Dustin M. Long, Steffanie Sabbaj, James J Kobie, Paul Goepfert, Nathan Erdmann |
JCI Insight | 2021 |
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Nucleocapsid-specific and PD-L1+CXCR3+ CD8 polyfunctional T-cell abundances are associated with survival of critical SARS-CoV2-infected patients
Lucille Adam, Pierre Rosenbaum, Paul Quentric, Christophe Parizot, Olivia Bonduelle, Noëlline Guillou, Aurelien Corneau, Karim Dorgham, Makoto Miyara, Charles-Edouard Luyt, Amélie Guihot, Guy Gorochov, Christophe Combadière, Behazine Combadière |
JCI Insight | 2021 |
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Inefficient Placental Virus Replication and Absence of Neonatal Cell-Specific Immunity Upon Sars-CoV-2 Infection During Pregnancy
AC Tallarek, C Urbschat, LF Brito, S Stanelle-Bertram, S Krasemann, G Frascaroli, K Thiele, A Wieczorek, N Felber, M Lütgehetmann, UR Markert, K Hecher, W Brune, F Stahl, G Gabriel, A Diemert, PC Arck |
Frontiers in immunology | 2021 |
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Immunologic memory to SARS-CoV-2 in convalescent COVID-19 patients at 1 year postinfection
H Hou, Y Zhang, G Tang, Y Luo, W Liu, C Cheng, Y Jiang, Z Xiong, S Wu, Z Sun, S Xu, X Fan, F Wang |
Journal of Allergy and Clinical Immunology | 2021 |
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Markers of Polyfunctional SARS-CoV-2 Antibodies in Convalescent Plasma
H Natarajan, AR Crowley, SE Butler, S Xu, JA Weiner, EM Bloch, K Littlefield, W Wieland-Alter, RI Connor, PF Wright, SE Benner, TS Bonny, O Laeyendecker, D Sullivan, S Shoham, TC Quinn, HB Larman, A Casadevall, A Pekosz, AD Redd, AA Tobian, ME Ackerman, MS Diamond |
mBio | 2021 |
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Identification of cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants
C Hu, M Shen, X Han, Q Chen, L Li, S Chen, J Zhang, F Gao, W Wang, Y Wang, T Li, S Li, J Huang, J Wang, J Zhu, D Chen, Q Wu, K Tao, D Pang, A Jin |
Genes & Diseases | 2021 |
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Protective heterologous T cell immunity in COVID-19 induced by the trivalent MMR and Tdap vaccine antigens
V Mysore, X Cullere, ML Settles, X Ji, MW Kattan, M Desjardins, B Durbin-Johnson, T Gilboa, LR Baden, DR Walt, AH Lichtman, L Jehi, TN Mayadas |
The American Journal of Medicine | 2021 |
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Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects
E Gallerani, D Proietto, B Dallan, M Campagnaro, S Pacifico, V Albanese, E Marzola, P Marconi, A Caputo, V Appay, R Gavioli, F Nicoli |
Frontiers in immunology | 2021 |
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The role of T‐cell immunity in COVID‐19 severity amongst people living with type II diabetes
ZW Tong, E Grant, S Gras, M Wu, C Smith, HL Barrett, LA Gallo, KR Short |
The FEBS journal | 2021 |
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Immune profiling of COVID-19: preliminary findings and implications for the pandemic
HT Maecker |
Journal for ImmunoTherapy of Cancer | 2021 |
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Adaptive immune responses to SARS-CoV-2
D Forthal |
Advanced Drug Delivery Reviews | 2021 |
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Binding of phosphatidylserine‐positive microparticles by PBMCs classifies disease severity in COVID‐19 patients
L Rausch, K Lutz, M Schifferer, E Winheim, R Gruber, EF Oesterhaus, L Rinke, JC Hellmuth, C Scherer, M Muenchhoff, C Mandel, M BergweltBaildon, M Simons, T Straub, AB Krug, J Kranich, T Brocker |
Journal of Extracellular Vesicles | 2021 |
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Nature of Acquired Immune Responses, Epitope Specificity and Resultant Protection from SARS-CoV-2
RM Gorczynski, RA Lindley, EJ Steele, NC Wickramasinghe |
Journal of Personalized Medicine | 2021 |
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Profiling CD8+ T cell epitopes of COVID-19 convalescents reveals reduced cellular immune responses to SARS-CoV-2 variants
H Zhang, S Deng, L Ren, P Zheng, X Hu, T Jin, X Tan |
Cell Reports | 2021 |
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Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein
P Chaurasia, TH Nguyen, LC Rowntree, JA Juno, AK Wheatley, SJ Kent, K Kedzierska, J Rossjohn, J Petersen |
The Journal of biological chemistry | 2021 |
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SARS-CoV-2 Specific IgG Antibodies Persist Over a 12-Month Period in Oral Mucosal Fluid Collected From Previously Infected Individuals
P Chellamuthu, AN Angel, MA MacMullan, N Denny, A Mades, M Santacruz, R Lopez, C Bagos, JG Casian, K Trettner, L Lopez, N Nirema, M Brobeck, N Kojima, JD Klausner, F Turner, V Slepnev, A Ibrayeva |
Frontiers in immunology | 2021 |
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Comparative performance of multiplex salivary and commercially available serologic assays to detect SARS-CoV-2 IgG and neutralization titers
CD Heaney, N Pisanic, PR Randad, K Kruczynski, T Howard, X Zhu, K Littlefield, EU Patel, R Shrestha, O Laeyendecker, S Shoham, D Sullivan, K Gebo, D Hanley, AD Redd, TC Quinn, A Casadevall, JM Zenilman, A Pekosz, EM Bloch, AA Tobian |
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology | 2021 |
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CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants
AD Redd, A Nardin, H Kared, EM Bloch, A Pekosz, O Laeyendecker, B Abel, M Fehlings, TC Quinn, AA Tobian |
Open Forum Infectious Diseases | 2021 |
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The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA-supertype-dependent manner
DJ Hamelin, D Fournelle, JC Grenier, J Schockaert, KA Kovalchik, P Kubiniok, F Mostefai, JD Duquette, F Saab, I Sirois, MA Smith, S Pattijn, H Soudeyns, H Decaluwe, J Hussin, E Caron |
Cell Systems | 2021 |
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Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals
A Johansson, U Malhotra, Y Kim, R Gomez, M Krist, A Wald, D Koelle, W Kwok, A Sant |
PLoS pathogens | 2021 |
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SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19
A Grifoni, J Sidney, R Vita, B Peters, S Crotty, D Weiskopf, A Sette |
Cell Host & Microbe | 2021 |
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Sequence similarity of HSP65 of Mycobacterium bovis BCG with SARS-CoV-2 spike and nuclear proteins: may it predict an antigen-dependent immune protection of BCG against COVID-19?
P Finotti |
Cell Stress and Chaperones | 2021 |
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Key Considerations for the Development of Safe and Effective SARS‐CoV‐2 Subunit Vaccine: A Peptide‐Based Vaccine Alternative
AO Shalash, WM Hussein, M Skwarczynski, I Toth |
Advanced Science | 2021 |
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Molecular Basis of a Dominant SARS-CoV-2 Spike-Derived Epitope Presented by HLA-A*02:01 Recognised by a Public TCR
C Szeto, AT Nguyen, CA Lobos, DS Chatzileontiadou, D Jayasinghe, EJ Grant, A Riboldi-Tunnicliffe, C Smith, S Gras |
Cells | 2021 |
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Screening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8+ T cell responses in HLA-A transgenic mice
X Jin, Y Ding, S Sun, X Wang, Z Zhou, X Liu, M Li, X Chen, A Shen, Y Wu, B Liu, J Zhang, J Li, Y Yang, H Qiu, C Shen, Y He, G Zhao |
Cellular and Molecular Immunology | 2021 |
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A Synthetic Peptide CTL Vaccine Targeting Nucleocapsid Confers Protection from SARS-CoV-2 Challenge in Rhesus Macaques
PE Harris, T Brasel, C Massey, CV Herst, S Burkholz, P Lloyd, T Blankenberg, TM Bey, R Carback, T Hodge, S Ciotlos, L Wang, JE Comer, RM Rubsamen |
Human vaccines | 2021 |
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CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer
EM Bange, NA Han, P Wileyto, JY Kim, S Gouma, J Robinson, AR Greenplate, MA Hwee, F Porterfield, O Owoyemi, K Naik, C Zheng, M Galantino, AR Weisman, CA Ittner, EM Kugler, AE Baxter, O Oniyide, RS Agyekum, TG Dunn, TK Jones, HM Giannini, ME Weirick, CM McAllister, NE Babady, A Kumar, AJ Widman, S DeWolf, SR Boutemine, C Roberts, KR Budzik, S Tollett, C Wright, T Perloff, L Sun, D Mathew, JR Giles, DA Oldridge, JE Wu, C Alanio, S Adamski, AL Garfall, LA Vella, SJ Kerr, JV Cohen, RA Oyer, R Massa, IP Maillard, KN Maxwell, JP Reilly, PG Maslak, RH Vonderheide, JD Wolchok, SE Hensley, EJ Wherry, NJ Meyer, AM DeMichele, SA Vardhana, R Mamtani, AC Huang |
Nature Medicine | 2021 |
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CD8 T cells compensate for impaired humoral immunity in COVID-19 patients with hematologic cancer
Alexander Huang, Erin Bange, Nicholas Han, E Paul Wileyto, Justin Kim, Sigrid Gouma, James Robinson, Allison Greenplate, Florence Porterfield, Olutosin Owoyemi, Karan Naik, Cathy Zheng, Michael Galantino, Ariel Weisman, Carolin Ittner, Emily Kugler, Amy Baxter, Madison Weirick, Christopher McAllister, Ngolela Esther Babady, Anita Kumar, Adam Widman, Susan Dewolf, Sawsan Boutemine, Charlotte Roberts, Krista Budzik, Susan Tollett, Carla Wright, Tara Perloff, Lova Sun, Divij Mathew, Josephine Giles, Derek Oldridge, Jennifer Wu, Cecile Alanio, Sharon Adamski, Laura Vella, Samuel Kerr, Justine Cohen, Randall Oyer, Ryan Massa, Ivan Maillard, Kara Maxwell, Peter Maslak, Robert Vonderheide, Jedd D Wolchok, Scott Hensley, E Wherry, Nuala Meyer, Angela DeMichele, Santosha Vardhana, Ronac Mamtani, Oluwatosin Oniyide, Roseline Agyekum, Thomas Dunn, Tiffanie Jones, Heather Giannini, Alfred Garfall, John Reilly |
Research square | 2021 |
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m6A Regulator-Mediated Methylation Modification Patterns and Characteristics of Immunity in Blood Leukocytes of COVID-19 Patients
X Qiu, X Hua, Q Li, Q Zhou, J Chen |
Frontiers in immunology | 2021 |
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An Overview of Recent Insights into the Response of TLR to SARS-CoV-2 Infection and the Potential of TLR Agonists as SARS-CoV-2 Vaccine Adjuvants
ME Kayesh, M Kohara, K Tsukiyama-Kohara |
Viruses | 2021 |
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The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
TI de Silva, G Liu, BB Lindsey, D Dong, SC Moore, NS Hsu, D Shah, D Wellington, AJ Mentzer, A Angyal, R Brown, MD Parker, Z Ying, X Yao, L Turtle, S Dunachie, MK Maini, G Ogg, JC Knight, Y Peng, SL Rowland-Jones, T Dong, DM Aanensen, K Abudahab, H Adams, A Adams, S Afifi, D Aggarwal, SS Ahmad, L Aigrain, A Alcolea-Medina, NF Alikhan, E Allara, R Amato, T Annett, S Aplin, CV Ariani, H Asad, A Ash, P Ashfield, F Ashford, L Atkinson, SW Attwood, C Auckland, A Aydin, DJ Baker, P Baker, CE Balcazar, J Ball, JC Barrett, M Barrow, E Barton, M Bashton, AR Bassett, R Batra, C Baxter, N Bayzid, C Beaver, AH Beckett, SM Beckwith, L Bedford, R Beer, A Beggs, KL Bellis, L Berry, B Bertolusso, A Best, E Betteridge, D Bibby, K Bicknell, D Binns, A Birchley, PW Bird, C Bishop, R Blacow, V Blakey, B Blane, F Bolt, J Bonfield, S Bonner, D Bonsall, T Boswell, A Bosworth, Y Bourgeois, O Boyd, DT Bradley, C Breen, C Bresner, J Breuer, S Bridgett, IF Bronner, E Brooks, A Broos, JR Brown, G Bucca, SL Buchan, 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iScience | 2021 |
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Seroconversion rate after vaccination against COVID-19 in patients with cancer—a systematic review
C Corti, G Antonarelli, F Scotté, JP Spano, J Barrière, JM Michot, F André, G Curigliano |
Annals of Oncology | 2021 |
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Allotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 spike glycoprotein
G Stamatakis, M Samiotaki, I Temponeras, G Panayotou, E Stratikos |
The Journal of biological chemistry | 2021 |
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Degenerate CD8 Epitopes Mapping to Structurally Constrained Regions of the Spike Protein: A T Cell-Based Way-Out From the SARS-CoV-2 Variants Storm
C Boni, D Cavazzini, A Bolchi, M Rossi, A Vecchi, C Tiezzi, V Barili, P Fisicaro, C Ferrari, S Ottonello |
Frontiers in immunology | 2021 |
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Virus-Induced CD8+ T-Cell Immunity and Its Exploitation to Contain the SARS-CoV-2 Pandemic
M Federico |
Human vaccines | 2021 |
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Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells in cynomolgus macaques
T Nomura, H Yamamoto, M Nishizawa, TT Hau, S Harada, H Ishii, S Seki, M Nakamura-Hoshi, M Okazaki, S Daigen, A Kawana-Tachikawa, N Nagata, N Iwata-Yoshikawa, N Shiwa, S Iida, H Katano, T Suzuki, ES Park, K Maeda, Y Suzaki, Y Ami, T Matano, B Lee |
PLoS pathogens | 2021 |
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Immune responses to COVID-19 vaccines in patients with cancer: Promising results and a note of caution
EA Griffiths, BH Segal |
Cancer Cell | 2021 |
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Multi-Subunit SARS-CoV-2 Vaccine Design Using Evolutionarily Conserved T- and B- Cell Epitopes
B Akbay, SH Abidi, MA Ibrahim, Z Mukhatayev, S Ali |
Human vaccines | 2021 |
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Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs
S Weingarten-Gabbay, S Klaeger, S Sarkizova, LR Pearlman, DY Chen, KM Gallagher, MR Bauer, HB Taylor, WA Dunn, C Tarr, J Sidney, S Rachimi, HL Conway, K Katsis, Y Wang, D Leistritz-Edwards, MR Durkin, CH Tomkins-Tinch, Y Finkel, A Nachshon, M Gentili, KD Rivera, IP Carulli, VA Chea, A Chandrashekar, CC Bozkus, M Carrington, N Bhardwaj, DH Barouch, A Sette, MV Maus, CM Rice, KR Clauser, DB Keskin, DC Pregibon, N Hacohen, SA Carr, JG Abelin, M Saeed, PC Sabeti, K Lavin-Parsons, B Parry, B Lilley, C Lodenstein, B McKaig, N Charland, H Khanna, J Margolin, A Gonye, I Gushterova, T Lasalle, N Sharma, BC Russo, M Rojas-Lopez, M Sade-Feldman, K Manakongtreecheep, J Tantivit, MF Thomas |
Cell | 2021 |
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SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity
C Motozono, M Toyoda, J Zahradnik, A Saito, H Nasser, TS Tan, I Ngare, I Kimura, K Uriu, Y Kosugi, Y Yue, R Shimizu, J Ito, S Torii, A Yonekawa, N Shimono, Y Nagasaki, R Minami, T Toya, N Sekiya, T Fukuhara, Y Matsuura, G Schreiber, T Ikeda, S Nakagawa, T Ueno, K Sato |
Cell Host & Microbe | 2021 |
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Landscape of epitopes targeted by T cells in 852 individuals recovered from COVID-19: Meta-analysis, immunoprevalence, and web platform
AA Quadeer, SF Ahmed, MR McKay |
Cell reports. Medicine | 2021 |
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SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patients
SK Saini, DS Hersby, T Tamhane, HR Povlsen, SP Hernandez, M Nielsen, AO Gang, SR Hadrup |
Science Immunology | 2021 |
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The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance
I Kimura, Y Kosugi, J Wu, J Zahradnik, D Yamasoba, EP Butlertanaka, YL Tanaka, K Uriu, Y Liu, N Morizako, K Shirakawa, Y Kazuma, R Nomura, Y Horisawa, K Tokunaga, T Ueno, A Takaori-Kondo, G Schreiber, H Arase, C Motozono, A Saito, S Nakagawa, K Sato |
Cell Reports | 2021 |
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Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8+ T Cells during Convalescence
Ma T, Ryu H, McGregor M, Babcock B, Neidleman J, Xie G, George AF, Frouard J, Murray V, Gill G, Ghosn E, Newell EW, Lee SA, Roan NR |
Journal of immunology (Baltimore, Md. : 1950) | 2021 |
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Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2
Francis JM, Leistritz-Edwards D, Dunn A, Tarr C, Lehman J, Dempsey C, Hamel A, Rayon V, Liu G, Wang Y, Wille M, Durkin M, Hadley K, Sheena A, Roscoe B, Ng M, Rockwell G, Manto M, Gienger E, Nickerson J, Moarefi A, Noble M, Malia T, Bardwell PD, Gordon W, Swain J, Skoberne M, Sauer K, Harris T, Goldrath AW, Shalek AK, Coyle AJ, Benoist C, Pregibon DC, Jilg N, Li J, Rosenthal A, Wong C, Daley G, Golan D, Heller H, Sharpe A, Abayneh BA, Allen P, Antille D, Armstrong K, Boyce S, Braley J, Branch K, Broderick K, Carney J, Chan A, Davidson S, Dougan M, Drew D, Elliman A, Flaherty K, Flannery J, Forde P, Gettings E, Griffin A, Grimmel S, Grinke K, Hall K, Healy M, Henault D, Holland G, Kayitesi C, LaValle V, Lu Y, Luthern S, Schneider JM, Martino B, McNamara R, Nambu C, Nelson S, Noone M, Ommerborn C, Pacheco LC, Phan N, Porto FA, Ryan E, Selleck K, Slaughenhaupt S, Sheppard KS, Suschana E, Wilson V, Carrington M, Martin M, Yuki Y, Alter G, Balazs A, Bals J, Barbash M, Bartsch Y, Boucau J, Carrington M, Chevalier J, Chowdhury F, DeMers E, Einkauf K, Fallon J, Fedirko L, Finn K, Garcia-Broncano P, Ghebremichael MS, Hartana C, Jiang C, Judge K, Kaplonek P, Karpell M, Lai P, Lam EC, Lefteri K, Lian X, Lichterfeld M, Lingwood D, Liu H, Liu J, Ly N, Hill ZM, Michell A, Millstrom I, Miranda N, O'Callaghan C, Osborn M, Pillai S, Rassadkina Y, Reissis A, Ruzicka F, Seiger K, Sessa L, Sharr C, Shin S, Singh N, Sun W, Sun X, Ticheli H, Trocha-Piechocka A, Walker B, Worrall D, Yu XG, Zhu A |
Science Immunology | 2021 |
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SARS‐CoV‐2‐specific CD8+ T‐cell responses and TCR signatures in the context of a prominent HLA‐A*24:02 allomorph
Rowntree LC, Petersen J, Juno JA, Chaurasia P, Wragg K, Koutsakos M, Hensen L, Wheatley AK, Kent SJ, Rossjohn J, Kedzierska K, Nguyen TH |
Immunology and Cell Biology | 2021 |
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Rise and exacerbation of oral lichen planus in the background of SARS-CoV-2 infection
Sood A, Raghavan S, Batra P, Sharma K, Talwar A |
Medical Hypotheses | 2021 |
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The T-cell response to SARS-CoV-2: kinetic and quantitative aspects and the case for their protective role
Bertoletti A, Tan AT, Le Bert N |
2021 | |
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Comparative performance of multiplex salivary and commercially available serologic assays to detect SARS-CoV-2 IgG and neutralization titers
Heaney CD, Pisanic N, Randad PR, Kruczynski K, Howard T, Zhu X, Littlefield K, Patel EU, Shrestha R, Laeyendecker O, Shoham S, Sullivan D, Gebo K, Hanley D, Redd AD, Quinn TC, Casadevall A, Zenilman JM, Pekosz A, Bloch EM, Tobian AA |
2021 | |
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CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants
Redd AD, Nardin A, Kared H, Bloch EM, Pekosz A, Laeyendecker O, Abel B, Fehlings M, Quinn TC, Tobian AA |
2021 | |
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Protracted yet coordinated differentiation of long-lived SARS-CoV-2-specific CD8+ T cells during COVID-19 convalescence
Ma T, Ryu H, McGregor M, Babcock B, Neidleman J, Xie G, George AF, Frouard J, Murray V, Gill G, Ghosn E, Newell E, Lee S, Roan NR |
2021 | |
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Impact of multiple sclerosis disease-modifying therapies on SARS-CoV-2 vaccine-induced antibody and T cell immunity
Sabatino JJ Jr, Mittl K, Rowles W, Mcpolin K, Rajan JV, Zamecnik CR, Dandekar R, Alvarenga BD, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Augusto DG, Alexander J, Hollenbach JA, Wilson MR, Zamvil SS, Bove R |
2021 | |
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Minimal cross-over between mutations associated with Omicron variant of SARS-CoV-2 and CD8+ T cell epitopes identified in COVID-19 convalescent individuals
Redd AD, Nardin A, Kared H, Bloch EM, Abel B, Pekosz A, Laeyendecker O, Fehlings M, Quinn TC, Tobian AA |
2021 |
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