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Treatment of primary HIV-1 infection with cyclosporin A coupled with highly active antiretroviral therapy
G. Paolo Rizzardi, … , Adriano Lazzarin, Giuseppe Pantaleo
G. Paolo Rizzardi, … , Adriano Lazzarin, Giuseppe Pantaleo
Published March 1, 2002
Citation Information: J Clin Invest. 2002;109(5):681-688. https://doi.org/10.1172/JCI14522.
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Article Immunology Article has an altmetric score of 9

Treatment of primary HIV-1 infection with cyclosporin A coupled with highly active antiretroviral therapy

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Abstract

Primary HIV-1 infection causes extensive immune activation, during which CD4+ T cell activation supports massive HIV-1 production. We tested the safety and the immune-modulating effects of combining cyclosporin A (CsA) treatment with highly active antiretroviral therapy (HAART) during primary HIV-1 infection. Nine adults with primary HIV-1 infection were treated with CsA along with HAART. At week 8, all patients discontinued CsA but maintained HAART. Viral replication was suppressed to a comparable extent in the CsA + HAART cohort and in 29 control patients whose primary infection was treated with HAART alone. CsA restored normal CD4+ T cell levels, both in terms of percentage and absolute numbers. The increase in CD4+ T cells was apparent within a week and persisted throughout the study period. CsA was not detrimental to virus-specific CD8+ or CD4+ T cell responses. At week 48, the proportion of IFN-γ–secreting CD4+ and CD4+CCR7– T cells was significantly higher in the CsA + HAART cohort than in the HAART-alone cohort. In conclusion, rapid shutdown of T cell activation in the early phases of primary HIV-1 infection can have long-term beneficial effects and establish a more favorable immunologic set-point. Appropriate, immune-based therapeutic interventions may represent a valuable complement to HAART for treating HIV infection.

Authors

G. Paolo Rizzardi, Alexandre Harari, Brunella Capiluppi, Giuseppe Tambussi, Kim Ellefsen, Donatella Ciuffreda, Patrick Champagne, Pierre-Alexandre Bart, Jean-Philippe Chave, Adriano Lazzarin, Giuseppe Pantaleo

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Clinical and laboratory characteristics prior to the initiation of thera...

Clinical and laboratory characteristics prior to the initiation of therapy in the two treatment cohorts


Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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Referenced in 3 patents
Referenced in 1 clinical guideline sources
10 readers on Mendeley
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