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Citations to this article

Recent endemic coronavirus infection is associated with less-severe COVID-19
Manish Sagar, … , Laura F. White, Joseph P. Mizgerd
Manish Sagar, … , Laura F. White, Joseph P. Mizgerd
Published September 30, 2020
Citation Information: J Clin Invest. 2021;131(1):e143380. https://doi.org/10.1172/JCI143380.
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Recent endemic coronavirus infection is associated with less-severe COVID-19

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Abstract

Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal common cold, and these eCoVs share extensive sequence homology with human SARS coronavirus 2 (SARS-CoV-2). Here, we show that individuals with, as compared with those without, a recent documented infection with eCoV were tested at greater frequency for respiratory infections but had a similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less-severe coronavirus disease 2019 (COVID-19) illness. Our observations suggest that preexisting immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.

Authors

Manish Sagar, Katherine Reifler, Michael Rossi, Nancy S. Miller, Pranay Sinha, Laura F. White, Joseph P. Mizgerd

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 Total
Citations: 9 27 46 69 93 5 249
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Citations to this article (249)

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Viruses 2023
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Cellular & molecular immunology 2023
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Journal of Clinical Investigation 2022
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JCI Insight 2022
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Clinical Infectious Diseases 2022
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Frontiers in immunology 2022
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Blood Cancer Journal 2022
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Nature Communications 2022
Two Opposing Roles of SARS-CoV-2 RBD-Reactive Antibodies in Pre-Pandemic Plasma Samples From Elderly People in ACE2-Mediated Pseudovirus Infection
K Sim, G Ko, S Bae, K Choi, J Lee, B Kim, K Lee, M Song, S Park
Frontiers in immunology 2022
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EBioMedicine 2022
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Nature Immunology 2022
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Immunity 2022
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The Journal of Microbiology 2022
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Nature Communications 2022
Age-Associated Seroprevalence of Coronavirus Antibodies: Population-Based Serosurveys in 2013 and 2020, British Columbia, Canada
G Tanunliong, A Liu, S Kaweski, M Irvine, R Reyes, D Purych, M Krajden, M Morshed, I Sekirov, S Gantt, D Skowronski, A Jassem
Frontiers in immunology 2022
Epidemiology and Clinical Characteristics of Human Coronaviruses-Associated Infections in Children: A Multi-Center Study
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Frontiers in Pediatrics 2022
Antibody and T Cell Immune Responses to SARS-CoV-2 Peptides in COVID-19 Convalescent Patients
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Frontiers in microbiology 2022
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Bhattacharya D
Immunity 2022
Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host Factors
Rovito R, Augello M, Ben-Haim A, Bono V, d\u2019Arminio Monforte A, Marchetti G
Frontiers in immunology 2022
The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19
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Life Sciences 2022
Mecanismos del COVID-19 en el cuerpo humano: Lo que sabemos hasta ahora
Kumar A, Narayan RK, Prasoon P, Kumari C, Kaur G, Kumar S, Kulandhasamy M, Sesham K, Pareek V, Faiq MA, Pandey SN, Singh HN, Kant K, Shekhawat PS, Raza K, Kumar S
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Northern Clinics of Istanbul 2022
Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles
Becerra-Artiles A, Calvo-Calle JM, Co MD, Nanaware PP, Cruz J, Weaver GC, Lu L, Forconi C, Finberg RW, Moormann AM, Stern LJ
Cell Reports 2022
The past, current and future epidemiological dynamic of SARS-CoV-2
Balloux F, Tan C, Swadling L, Richard D, Jenner C, Maini M, van Dorp L
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Cell Host & Microbe 2022
The immunopathogenesis of SARS‐CoV‐2 infection in children: diagnostics, treatment and prevention
Patel H, McArdle A, Seaby E, Levin M, Whittaker E
IBMS BoneKEy 2022
Frequent Infection of Cats With SARS-CoV-2 Irrespective of Pre-Existing Enzootic Coronavirus Immunity, Brazil 2020
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Frontiers in immunology 2022
Cross‐reactive cellular, but not humoral, immunity is detected between OC43 and SARS‐CoV‐2 NPs in people not infected with SARS‐CoV‐2: Possible role of cTFH cells
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Journal of leukocyte biology 2022
The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection
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Frontiers in immunology 2022
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Immunological Reviews 2022
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Immunological Reviews 2022
Effects of Antibody Responses to Pre-Existing Coronaviruses on Disease Severity and Complement Activation in COVID-19 Patients
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Journal of Medical Virology 2022
SARS-CoV-2 Omicron Variant: Epidemiological Features, Biological Characteristics, and Clinical Significance
Guo Y, Han J, Zhang Y, He J, Yu W, Zhang X, Wu J, Zhang S, Kong Y, Guo Y, Lin Y, Zhang J
Frontiers in immunology 2022
Understanding COVID-19 Vaccines Today: Are T-cells Key Players?
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Vaccination with BNT162b2 and ChAdOx1 nCoV-19 Induces Cross-Reactive Anti-RBD IgG against SARS-CoV-2 Variants including Omicron
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Preexisting Humoral Immunity Cross-Reacting with SARS-CoV-2 Might Prevent Death Due to COVID-19 in Critical Patients
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Journal of Clinical Medicine 2022
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Phytochemical Discrimination, Biological Activity and Molecular Docking of Water-Soluble Inhibitors from Saussurea costus Herb against Main Protease of SARS-CoV-2
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Molecules (Basel, Switzerland) 2022
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Clinical Infectious Diseases 2022
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Solomon MD, Escobar GJ, Lu Y, Schlessinger D, Steinman JB, Steinman L, Lee C, Liu VX
Proceedings of the National Academy of Sciences 2022
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Bertoletti A, Le Bert N, Tan AT
Immunity 2022
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Frontiers in immunology 2022
Act Early and at the Right Location: SARS-CoV-2 T Cell Kinetics and Tissue Localization
Bertoletti A, Le Bert N, Tan AT
International journal of molecular sciences 2022
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iScience 2022
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Frontiers in immunology 2022
The potential of Beta variant containing COVID booster vaccines for chasing Omicron in 2022
Sridhar S, Chicz RM, Warren W, Tartaglia J, Savarino S, Gurunathan S, Toussaint JF
Nature Communications 2022
Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals
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Scientific Reports 2022
The immune response as a double‐edged sword: The lesson learnt during the COVID‐19 pandemic
Agrati C, Carsetti R, Bordoni V, Sacchi A, Quintarelli C, Locatelli F, Ippolito G, Capobianchi MR
Immunology 2022
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Cell reports. Medicine 2022
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Frontiers in immunology 2022
SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinations
Anderson EM, Li SH, Awofolaju M, Eilola T, Goodwin E, Bolton MJ, Gouma S, Manzoni TB, Hicks P, Goel RR, Painter MM, Apostolidis SA, Mathew D, Dunbar D, Fiore D, Brock A, Weaver J, Millar JS, DerOhannessian S, Greenplate AR, Frank I, Rader DJ, Wherry EJ, Bates P, Hensley SE
Cell Reports 2022
Divergent SARS-CoV-2-specific T cell responses in intensive care unit workers following mRNA COVID-19 vaccination
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Frontiers in immunology 2022
Understanding the exceptional pre-vaccination Era East Asian COVID-19 outcomes
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Advances in Biological Regulation 2022
A ubiquitous bone marrow reservoir of preexisting SARS-CoV-2-reactive memory CD4+ T lymphocytes in unexposed individuals
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Frontiers in immunology 2022
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Sun Y, Zou Y, Wang H, Cui G, Yu Z, Ren Z
Frontiers in Cellular and Infection Microbiology 2022
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Ensho Saisei 2022
BNT162b2 induces robust cross-variant SARS-CoV-2 immunity in children.
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npj Vaccines 2022
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Shafqat A, Omer MH, Ahmad O, Niaz M, Abdulkader HS, Shafqat S, Mushtaq AH, Shaik A, Elshaer AN, Kashir J, Alkattan K, Yaqinuddin A
Frontiers in immunology 2022
The impact of pre-existing cross-reactive immunity on SARS-CoV-2 infection and vaccine responses
Murray SM, Ansari AM, Frater J, Klenerman P, Dunachie S, Barnes E, Ogbe A
Nature reviews. Immunology 2022
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
Khoo WH, Jackson K, Phetsouphanh C, Zaunders JJ, Alquicira-Hernandez J, Yazar S, Ruiz-Diaz S, Singh M, Dhenni R, Kyaw W, Tea F, Merheb V, Lee FX, Burrell R, Howard-Jones A, Koirala A, Zhou L, Yuksel A, Catchpoole DR, Lai CL, Vitagliano TL, Rouet R, Christ D, Tang B, West NP, George S, Gerrard J, Croucher PI, Kelleher AD, Goodnow CG, Sprent JD, Powell JE, Brilot F, Nanan R, Hsu PS, Deenick EK, Britton PN, Phan TG
Clinical Immunology 2022
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Luo Y, Lv H, Zhao S, Sun Y, Liu C, Chen C, Liang W, Kwok KO, Teo QW, So RT, Lin Y, Deng Y, Li B, Dai Z, Zhu J, Zhang D, Fernando J, Wu NC, Tun HM, Bruzzone R, Mok CK, Mu X
International Journal of Infectious Diseases 2022
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Immunity 2022
Immunological memory to Common Cold Coronaviruses assessed longitudinally over a three-year period
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David K. Meyerholz, Stanley Perlman
Journal of Clinical Investigation 2021
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Journal of Clinical Investigation 2021
Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality
William R. Morgenlander, Stephanie Henson, Daniel Monaco, Athena Chen, Kirsten Littlefield, Evan Bloch, Eric Fujimura, Ingo Ruczinski, Andrew Crowley, Harini Natarajan, Savannah Butler, Joshua Weiner, Mamie Li, Tania Bonny, Sarah Benner, Ashwin Balagopal, David Sullivan, Shmuel Shoham, Thomas Quinn, Susan Eshleman, Arturo Casadevall, Andrew Redd, Oliver Laeyendecker, Margaret Ackerman, Andrew Pekosz, Steve Elledge, Matthew Robinson, Aaron Tobian, H. Larman
Journal of Clinical Investigation 2021
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Journal of Clinical Investigation 2021
Lung resident memory B cells protect against bacterial pneumonia
Kimberly A. Barker, Neelou S. Etesami, Anukul T. Shenoy, Emad I. Arafa, Carolina Lyon De Ana, Nicole Smith, Ian Martin, Wesley N Goltry, Alexander M.S. Barron, Jeffrey L. Browning, Hasmeena Kathuria, Anna C. Belkina, Antoine Guillon, Xuemei Zhong, Nicholas A Crossland, Matthew Jones, Lee J. Quinton, Joseph P. Mizgerd
Journal of Clinical Investigation 2021
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Tanushree Dangi, Nicole Palacio, Sarah Sanchez, Mincheol Park, Jake Class, Lavanya Visvabharathy, Thomas Ciucci, Igor Koralnik, Justin M Richner, Pablo Penaloza-MacMaster
Journal of Clinical Investigation 2021
A majority of uninfected adults show pre-existing antibody reactivity against SARS-CoV-2
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JCI Insight 2021
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JCI Insight 2021
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CT Deakin, GH Cornish, KW Ng, N Faulkner, W Bolland, J Hope, A Rosa, R Harvey, S Hussain, C Earl, BR Jebson, MG Wilkinson, LR Marshall, K OBrien, EC Rosser, A Radziszewska, H Peckham, H Patel, J Heaney, H Rickman, S Paraskevopoulou, CF Houlihan, MJ Spyer, SJ Gamblin, J McCauley, E Nastouli, M Levin, P Cherepanov, C Ciurtin, LR Wedderburn, G Kassiotis
The American Journal of Medicine 2021
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S Winklmeier, K Eisenhut, D Taskin, H Rübsamen, R Gerhards, C Schneider, PR Wratil, M Stern, P Eichhorn, OT Keppler, M Klein, S Mader, T Kümpfel, E Meinl
iScience 2021
Relative Ratios of Human Seasonal Coronavirus Antibodies Predict the Efficiency of Cross-Neutralization of SARS-CoV-2 Spike Binding to ACE2
Y Galipeau, V Siragam, G Laroche, E Marion, M Greig, M McGuinty, RA Booth, Y Durocher, M Cuperlovic-Culf, SA Bennett, AM Crawley, PM Giguère, C Cooper, MA Langlois
EBioMedicine 2021
Immunogenicity and crossreactivity of antibodies to the nucleocapsid protein of SARS-CoV-2: utility and limitations in seroprevalence and immunity studies
C Dobaño, R Santano, A Jiménez, M Vidal, J Chi, NR Melero, M Popovic, R López-Aladid, L Fernández-Barat, M Tortajada, F Carmona-Torre, G Reina, A Torres, A Mayor, C Carolis, AL García-Basteiro, R Aguilar, G Moncunill, L Izquierdo
Translational research : the journal of laboratory and clinical medicine 2021
Less severe course of COVID-19 is associated with elevated levels of antibodies against seasonal human coronaviruses OC43 and HKU1 (HCoV OC43, HCoV HKU1)
M Dugas, T Grote-Westrick, R Vollenberg, E Lorentzen, T Brix, H Schmidt, PR Tepasse, J Kühn
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2021
T cell immunity to SARS-CoV-2
J Niessl, T Sekine, M Buggert
Seminars in Immunology 2021
Repeated Exposure to Subinfectious Doses of SARS-CoV-2 May Promote T Cell Immunity and Protection against Severe COVID-19
ML Angelis, F Francescangeli, R Rossi, A Giuliani, RD Maria, A Zeuner
Viruses 2021
Cross-reactive antibodies after SARS-CoV-2 infection and vaccination
M Grobben, K van der Straten, PJ Brouwer, M Brinkkemper, P Maisonnasse, N Dereuddre-Bosquet, B Appelman, AH Lavell, LA van Vught, JA Burger, M Poniman, M Oomen, D Eggink, TP Bijl, HD van Willigen, E Wynberg, BJ Verkaik, OJ Figaroa, PJ de Vries, TM Boertien, MK Bomers, JJ Sikkens, RL Grand, MD de Jong, M Prins, AW Chung, GJ de Bree, RW Sanders, MJ van Gils
eLife 2021
Differential T-Cell Reactivity to Endemic Coronaviruses and SARS-CoV-2 in Community and Health Care Workers
R da Silva Antunes, S Pallikkuth, E Williams, ED Yu, J Mateus, L Quiambao, E Wang, SA Rawlings, D Stadlbauer, K Jiang, F Amanat, D Arnold, D Andrews, I Fuego, JM Dan, A Grifoni, D Weiskopf, F Krammer, S Crotty, ME Hoffer, SG Pahwa, A Sette
The Journal of Infectious Diseases 2021
Cross-reactive antibody against human coronavirus OC43 spike protein correlates with disease severity in COVID-19 patients: a retrospective study
L Guo, Y Wang, L Kang, Y Hu, L Wang, J Zhong, H Chen, L Ren, X Gu, G Wang, C Wang, X Dong, C Wu, L Han, Y Wang, G Fan, X Zou, H Li, J Xu, Q Jin, B Cao, J Wang
Emerging Microbes & Infections 2021
Adaptive immunity to human coronaviruses is widespread but low in magnitude
HX Tan, WS Lee, KM Wragg, C Nelson, R Esterbauer, HG Kelly, T Amarasena, R Jones, G Starkey, BZ Wang, O Yoshino, T Tiang, ML Grayson, H Opdam, R D'Costa, A Vago, LK Mackay, CL Gordon, AK Wheatley, SJ Kent, JA Juno, G Przybylowski, D Pritchard, R Moore, R Balakas, C Asmus, R Batac
IBMS BoneKEy 2021
Distinct Features and Functions of Systemic and Mucosal Humoral Immunity Among SARS-CoV-2 Convalescent Individuals
SE Butler, AR Crowley, H Natarajan, S Xu, JA Weiner, CA Bobak, DE Mattox, J Lee, W Wieland-Alter, RI Connor, PF Wright, ME Ackerman
Frontiers in immunology 2021
The Journal of Clinical Investigation in the time of COVID-19
A Casadevall, S Jackson, GL Semenza, GF Tomaselli, RS Ahima
Journal of Clinical Investigation 2021
Adaptive immunity to SARS-CoV-2 and COVID-19
A Sette, S Crotty
Cell 2021
SARS-CoV-2-Specific T Cell Responses in Patients with COVID-19 and Unexposed Individuals
MS Rha, AR Kim, EC Shin
Immune Network 2021
Phenotypes and Functions of SARS-CoV-2-Reactive T Cells
MK Jung, EC Shin
Molecules and Cells 2021
Detection of pre-existing SARS-CoV-2-reactive T cells in unexposed renal transplant patients
M Anft, A Blazquez-Navarro, U Stervbo, S Skrzypczyk, O Witzke, R Wirth, M Choi, C Hugo, P Reinke, TL Meister, E Steinmann, S Pfaender, P Schenker, R Viebahn, TH Westhoff, N Babel
Journal of Nephrology 2021
Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms
MA Cappel, JA Cappel, DA Wetter
Mayo Clinic Proceedings 2021
Why Does the Severity of COVID-19 Differ With Age?: Understanding the Mechanisms Underlying the Age Gradient in Outcome Following SARS-CoV-2 Infection
P Zimmermann, N Curtis
The Pediatric Infectious Disease Journal 2021
Most Japanese individuals are genetically predisposed to recognize an immunogenic protein fragment shared between COVID-19 and common cold coronaviruses
JM Dijkstra, AP Frenette, B Dixon
F1000Research 2021
Preexisting vs. de novo antibodies against SARS-CoV-2 in individuals without or with virus infection: impact on antibody therapy, vaccine research and serological testing
K Muthumani, Z Xu, M Jeong, JN Maslow, VS Kalyanaraman, A Srinivasan
Translational Medicine Communications 2021
Cross-Reactive Immune Responses toward the Common Cold Human Coronaviruses and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Mini-Review and a Murine Study
RE Sealy, JL Hurwitz
Microorganisms 2021
Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals
A Johansson, U Malhotra, Y Kim, R Gomez, M Krist, A Wald, D Koelle, W Kwok, A Sant
PLoS pathogens 2021
An evaluation of patients with a previous endemic coronavirus infection during the COVID‐19 pandemic
B Otlu, Y Yakupogullari, ES Tanriverdi, Y Bayindir
Journal of Medical Virology 2021
Development of T-cell immunity in a liver and hematopoietic stem cell transplant recipient following coronavirus disease 2019 infection
M Soni, E Migliori, A Assal, HT Chan, R Ciubotariu, JB Pan, K Cicero, M Pereira, MY Mapara, P Muranski
Cytotherapy 2021
A comprehensive review on efficient approaches for combating coronaviruses
M Pouresmaieli, E Ekrami, A Akbari, N Noorbakhsh, NB Moghadam, M Mamoudifard
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2021
Nanomedicine: A Diagnostic and Therapeutic Approach to COVID-19
A Sharma, K Kontodimas, M Bosmann
Frontiers in Medicine 2021
Do Islanders Have a More Reactive Behavioral Immune System? Social Cognitions and Preferred Interpersonal Distances During the COVID-19 Pandemic
I Hromatko, A Grus, G Kolđeraj
Frontiers in psychology 2021
Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection
SA Lapp, VV Edara, A Lu, L Lai, L Hussaini, A Chahroudi, LJ Anderson, MS Suthar, EJ Anderson, CA Rostad, VC Huber
PloS one 2021
Comparable endemic coronavirus nucleoprotein‐specific antibodies in mild and severe Covid‐19 patients
S Leach, AM Harandi, T Bergström, LM Andersson, S Nilsson, L Hoek, M Gisslén
Journal of Medical Virology 2021
Potential Protection of Pre-Existent Antibodies to Human Coronavirus 229E on COVID-19 Severity
O Guzmán-Martínez, K Guardado, M Varela-Cardoso, A Trujillo-Rivera, I Gómez-Ñañez, MC Ortiz-León, R Espinosa, C Ramos, JI Pérez-Carreón, DV López-Guerrero, CL Sampieri, AB Alanís-García, F Rojas-Durán, R Zenteno-Cuevas, M Gutiérrez, H Montero
International journal of environmental research and public health 2021
Neglected roles of IgG Fc-binding protein secreted from airway mucin-producing cells in protecting against SARS-CoV-2 infection
K Kobayashi, M Tachibana, Y Tsutsumi
Innate immunity 2021
Vaccines beyond antibodies: Spurred by pandemic research, are T‐cell vaccines moving closer to reality?
A King
EMBO reports 2021
SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19
A Grifoni, J Sidney, R Vita, B Peters, S Crotty, D Weiskopf, A Sette
Cell Host & Microbe 2021
Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection
EM Anderson, EC Goodwin, A Verma, CP Arevalo, MJ Bolton, ME Weirick, S Gouma, CM McAllister, SR Christensen, JE Weaver, P Hicks, TB Manzoni, O Oniyide, H Ramage, D Mathew, AE Baxter, DA Oldridge, AR Greenplate, JE Wu, C Alanio, K DAndrea, O Kuthuru, J Dougherty, A Pattekar, J Kim, N Han, SA Apostolidis, AC Huang, LA Vella, L Kuri-Cervantes, MB Pampena, MR Betts, EJ Wherry, NJ Meyer, S Cherry, P Bates, DJ Rader, SE Hensley
Cell 2021
Prospective Assessment of SARS-CoV-2 Seroconversion (PASS) study: an observational cohort study of SARS-CoV-2 infection and vaccination in healthcare workers
BM Jackson-Thompson, E Goguet, ED Laing, CH Olsen, S Pollett, KM Hollis-Perry, SE Maiolatesi, L Illinik, KF Ramsey, AE Reyes, Y Alcorta, MA Wong, J Davies, O Ortega, E Parmelee, AR Lindrose, M Moser, E Graydon, AG Letizia, CA Duplessis, A Ganesan, KP Pratt, AM Malloy, DW Scott, SK Anderson, AL Snow, CL Dalgard, JH Powers, D Tribble, TH Burgess, CC Broder, E Mitre
BMC Infectious Diseases 2021
High Levels of Common Cold Coronavirus Antibodies in Convalescent Plasma Are Associated With Improved Survival in COVID-19 Patients
U Greenbaum, K Klein, F Martinez, J Song, PF Thall, JL Ramdial, C Knape, FM Aung, J Scroggins, A Knopfelmacher, V Mulanovich, J Borjan, J Adachi, M Muthu, C Leung, MC Medina, R Champlin, A Olson, A Alousi, K Rezvani, EJ Shpall
Frontiers in immunology 2021
Authors’ Reply to Sprengholz and Betsch: “Willingness to Pay for a COVID-19 Vaccine”
LY García, AA Cerda
Applied Health Economics and Health Policy 2021
Isolation of Antibodies Against the Spike Protein of SARS-CoV from Pig Serum for Competitive Immunoassay
J Jung, JH Bong, TH Kim, JS Sung, C Lee, MJ Kang, HO Kim, HJ Shin, JC Pyun
BioChip Journal 2021
Prevalence of Neutralising Antibodies to HCoV-NL63 in Healthy Adults in Australia
SA Lynch, K Subbarao, S Mahanty, BE Barber, EV Roulis, L van der Hoek, JS McCarthy, KM Spann
Viruses 2021
Detection of Serum Cross-Reactive Antibodies and Memory Response to SARS-CoV-2 in Prepandemic and Post–COVID-19 Convalescent Samples
K Shrwani, R Sharma, M Krishnan, T Jones, M Mayora-Neto, D Cantoni, NJ Temperton, SL Dobson, K Subramaniam, PS McNamara, NA Cunliffe, L Turtle, Q Zhang
The Journal of Infectious Diseases 2021
Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells
J Mateus, JM Dan, Z Zhang, CR Moderbacher, M Lammers, B Goodwin, A Sette, S Crotty, D Weiskopf
Science 2021
Seven-month kinetics of SARS-CoV-2 antibodies and role of pre-existing antibodies to human coronaviruses
N Ortega, M Ribes, M Vidal, R Rubio, R Aguilar, S Williams, D Barrios, S Alonso, P Hernández-Luis, RA Mitchell, C Jairoce, A Cruz, A Jimenez, R Santano, S Méndez, M Lamoglia, N Rosell, A Llupià, L Puyol, J Chi, NR Melero, D Parras, P Serra, E Pradenas, B Trinité, J Blanco, A Mayor, S Barroso, P Varela, A Vilella, A Trilla, P Santamaria, C Carolis, M Tortajada, L Izquierdo, A Angulo, P Engel, AL García-Basteiro, G Moncunill, C Dobaño
Nature Communications 2021
Severe asthma in the era of COVID-19: A narrative review
J Gaspar-Marques, M van Zeller, P Carreiro-Martins, CC Loureiro
2021
The Conundrum of Low COVID-19 Mortality Burden in sub-Saharan Africa: Myth or Reality?
J Adams, MJ MacKenzie, AK Amegah, A Ezeh, MA Gadanya, A Omigbodun, AM Sarki, P Thistle, AK Ziraba, S Stranges, M Silverman
2021
Differential pre-pandemic breast milk IgA reactivity against SARS-CoV-2 and circulating human coronaviruses in Ugandan and American mothers
TG Egwang, TJ Owalla, E Okurut, G Apungia, A Fox, CD Carlo, RL Powell
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2021
Broad respiratory testing to identify SARS-CoV-2 viral co-circulation and inform diagnostic stewardship in the COVID-19 pandemic
NC Marshall, RM Kariyawasam, N Zelyas, JN Kanji, MA Diggle
Virology Journal 2021
Highly conserved, non-human-like, and cross-reactive SARS-CoV-2 T cell epitopes for COVID-19 vaccine design and validation
LM Meyers, AH Gutiérrez, CM Boyle, F Terry, BG McGonnigal, A Salazar, MF Princiotta, WD Martin, AS Groot, L Moise
npj Vaccines 2021
Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection
RR Yuen, D Steiner, RM Pihl, E Chavez, A Olson, EL Smith, LA Baird, F Korkmaz, P Urick, M Sagar, JL Berrigan, S Gummuluru, RB Corley, K Quillen, AC Belkina, G Mostoslavsky, IR Rifkin, Y Kataria, AJ Cappione, W Gao, NH Lin, N Bhadelia, JE Snyder-Cappione
Frontiers in immunology 2021
Immunity to SARS-CoV-2: Lessons Learned
J Fergie, A Srivastava
Frontiers in immunology 2021
Development and Application of Human Coronavirus Protein Microarray for Specificity Analysis
PX Du, YY Chou, HM Santos, BB Keskin, MH Hsieh, TS Ho, JY Wang, YL Lin, GD Syu
Analytical Chemistry 2021
COVID-19 Mechanisms in the Human Body—What We Know So Far
A Kumar, RK Narayan, P Prasoon, C Kumari, G Kaur, S Kumar, M Kulandhasamy, K Sesham, V Pareek, MA Faiq, SN Pandey, HN Singh, K Kant, PS Shekhawat, K Raza, S Kumar
Frontiers in immunology 2021
Longitudinal Follow Up of Immune Responses to SARS-CoV-2 in Health Care Workers in Sweden With Several Different Commercial IgG-Assays, Measurement of Neutralizing Antibodies and CD4+ T-Cell Responses
E Marklund, S Leach, K Nyström, A Lundgren, JÅ Liljeqvist, S Nilsson, A Yilmaz, LM Andersson, M Bemark, M Gisslén
Frontiers in immunology 2021
The associations of previous influenza/upper respiratory infection with COVID-19 susceptibility/morbidity/mortality: a nationwide cohort study in South Korea
SY Kim, JH Kim, M Kim, JH Wee, Y Jung, C Min, DM Yoo, S Sim, HG Choi
Scientific Reports 2021
Evolution of SARS-CoV-2: Review of Mutations, Role of the Host Immune System
H Banoun
Nephron. Clinical practice 2021
Antibody and B cell responses to SARS-CoV-2 infection and vaccination
K Röltgen, SD Boyd
Cell Host & Microbe 2021
Heterologous humoral immunity to human and zoonotic coronaviruses: Aiming for the achilles heel
KW Ng, N Faulkner, AG Wrobel, SJ Gamblin, G Kassiotis
Seminars in Immunology 2021
Humoral response to SARS‐CoV‐2 and seasonal coronaviruses in COVID‐19 patients
O Adams, M Andrée, D Rabl, PN Ostermann, H Schaal, E Lehnert, S Ackerstaff, L Müller, JC Fischer
Journal of Medical Virology 2021
Viral Coinfection is Associated with Improved Outcomes in Emergency Department Patients with SARS-CoV-2
E Goldberg, K Hasegawa, A Lawrence, J Kline, C Camargo
Western Journal of Emergency Medicine 2021
Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19
M Dugas, T Grote-Westrick, U Merle, M Fontenay, AE Kremer, F Hanses, R Vollenberg, E Lorentzen, S Tiwari-Heckler, J Duchemin, S Ellouze, M Vetter, J Fürst, P Schuster, T Brix, CM Denkinger, C Müller-Tidow, H Schmidt, PR Tepasse, J Kühn
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2021
Pre-Existing Cross-Reactive Antibody Responses Do Not Significantly Impact Inactivated COVID-19 Vaccine-Induced Neutralization
J Wang, C Guo, L Cai, C Liao, H Yi, Q Li, H Hu, Q Deng, Y Lu, Z Guo, Z Chen, J Lu
Frontiers in immunology 2021
Cross-Reactive Antibodies to SARS-CoV-2 and MERS-CoV in Pre-COVID-19 Blood Samples from Sierra Leoneans
R Borrega, DK Nelson, AP Koval, NG Bond, ML Heinrich, MM Rowland, R Lathigra, DJ Bush, I Aimukanova, WN Phinney, SA Koval, AR Hoffmann, AR Smither, AR Bell-Kareem, LI Melnik, KJ Genemaras, K Chao, P Snarski, AB Melton, JE Harrell, AA Smira, DH Elliott, JA Rouelle, G Sabino-Santos, AC Drouin, M Momoh, JD Sandi, A Goba, RJ Samuels, L Kanneh, M Gbakie, ZL Branco, JG Shaffer, JS Schieffelin, JE Robinson, DN Fusco, PC Sabeti, KG Andersen, DS Grant, ML Boisen, LM Branco, RF Garry
Viruses 2021
Early IgG / IgA response in hospitalized COVID-19 patients is associated with a less severe disease
G Fedele, G Russo, I Schiavoni, P Leone, E Olivetta, V Perri, MA Zingaropoli, MR Ciardi, P Pasculli, CM Mastroianni, P Stefanelli
Diagnostic Microbiology and Infectious Disease 2021
Neutralizing antibody responses following natural SARS-CoV-2 infection: Dynamics and correlation with commercial serologic tests
I Montesinos, H Dahma, F Wolff, N Dauby, S Delaunoy, M Wuyts, C Detemmerman, C Duterme, O Vandenberg, C Martin, M Hallin
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2021
Application of Pandemic Intelligence in Dynamic Data in Taiwan
TY Chang, WR Su, H Chen, MW Huang, LY Chen
International journal of environmental research and public health 2021
Coronavirus Disease 2019 Mitigation Strategies Were Associated With Decreases in Other Respiratory Virus Infections
P Sinha, K Reifler, M Rossi, M Sagar
Open Forum Infectious Diseases 2021
Pre-existing T cell-mediated cross-reactivity to SARS-CoV-2 cannot solely be explained by prior exposure to endemic human coronaviruses
CC Tan, CJ Owen, CY Tham, A Bertoletti, L van Dorp, F Balloux
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2021
Association of the past epidemic of Mycobacterium tuberculosis with mortality and incidence of COVID-19
K Inoue, S Kashima, AA Izzo
PloS one 2021
Ophthalmological Considerations for COVID-19 Vaccination in Patients with Inflammatory Eye Diseases and Autoimmune Disorders
CY Chau, LL Chow, S Sridhar, KC Shih
Ophthalmology and Therapy 2021
Pre-existing T-cell immunity to SARS-CoV-2 in unexposed healthy controls in Ecuador, as detected with a COVID-19 Interferon-Gamma Release Assay
G Echeverría, Á Guevara, J Coloma, AM Ruiz, MM Vasquez, E Tejera, JH de Waard
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2021
Absence of association between 2019‐20 influenza vaccination and COVID‐19: Results of the European I‐MOVE‐COVID‐19 primary care project, March‐August 2020
E Kissling, M Hooiveld, M Brytting, AM Vilcu, M Lange, I MartínezBaz, D Sigerson, T Enkirch, S Belhillil, A Meijer, J Castilla, N William, AS Carnahan, A Falchi, J Hendriksen, I Casado, J Murray, V Enouf, F Dijkstra, DF Marques, M Valenciano
Influenza and Other Respiratory Viruses 2021
Low-dose and oral exposure to SARS-CoV-2 may help us understand and prevent severe COVID-19
WP Hausdorff, J Flores
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2021
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2
L Swadling, MO Diniz, NM Schmidt, OE Amin, A Chandran, E Shaw, C Pade, JM Gibbons, NL Bert, AT Tan, A Jeffery-Smith, CC Tan, CY Tham, S Kucykowicz, G Aidoo-Micah, J Rosenheim, J Davies, M Johnson, MP Jensen, G Joy, LE McCoy, AM Valdes, BM Chain, D Goldblatt, DM Altmann, RJ Boyton, C Manisty, TA Treibel, JC Moon, H Abbass, A Abiodun, M Alfarih, Z Alldis, M Andiapen, J Artico, JB Augusto, GL Baca, SN Bailey, AN Bhuva, A Boulter, R Bowles, RJ Boyton, OV Bracken, B OBrien, T Brooks, N Bullock, DK Butler, G Captur, N Champion, C Chan, D Collier, JC de Sousa, X Couto-Parada, T Cutino-Mogue, RH Davies, B Douglas, CD Genova, K Dieobi-Anene, A Ellis, K Feehan, M Finlay, M Fontana, N Forooghi, C Gaier, D Gilroy, M Hamblin, G Harker, J Hewson, LM Hickling, AD Hingorani, L Howes, A Hughes, G Hughes, R Hughes, I Itua, V Jardim, WY Lee, MP Jensen, J Jones, M Jones, G Joy, V Kapil, H Kurdi, J Lambourne, KM Lin, S Louth, V Mandadapu, Á McKnight, K Menacho, C Mfuko, O Mitchelmore, C Moon, D Munoz-Sandoval, SM Murray, M Noursadeghi, A Otter, S Palma, R Parker, K Patel, B Pawarova, SE Petersen, B Piniera, FP Pieper, D Pope, M Prossora, L Rannigan, A Rapala, CJ Reynolds, A Richards, M Robathan, G Sambile, A Semper, A Seraphim, M Simion, A Smit, M Sugimoto, S Taylor, N Temperton, S Thomas, GD Thornton, A Tucker, J Veerapen, M Vijayakumar, S Welch, T Wodehouse, L Wynne, D Zahedi, L van Dorp, F Balloux, Á McKnight, M Noursadeghi, A Bertoletti, MK Maini
Nature 2021
Evidence for increased SARS-CoV-2 susceptibility and COVID-19 severity related to pre-existing immunity to seasonal coronaviruses
PR Wratil, NA Schmacke, B Karakoc, A Dulovic, D Junker, M Becker, U Rothbauer, A Osterman, PM Spaeth, A Ruhle, M Gapp, S Schneider, M Muenchhoff, JC Hellmuth, C Scherer, J Mayerle, M Reincke, J Behr, S Kääb, B Zwissler, M von Bergwelt-Baildon, J Eberle, L Kaderali, N Schneiderhan-Marra, V Hornung, OT Keppler
Cell Reports 2021
Knowledge into the Practice against COVID-19: A Cross-Sectional Study from Ghana
P Yeboah, DB Daliri, AY Abdin, E Appiah-Brempong, W Pitsch, AB Panyin, EB Adusei, A Razouk, MJ Nasim, C Jacob
International journal of environmental research and public health 2021
Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response
CY Lin, J Wolf, DC Brice, Y Sun, M Locke, S Cherry, AH Castellaw, M Wehenkel, JC Crawford, VI Zarnitsyna, D Duque, KJ Allison, EK Allen, SA Brown, AH Mandarano, JH Estepp, C Taylor, C Molina-Paris, S Schultz-Cherry, L Tang, PG Thomas, MA McGargill, AH Gaur, JM Hoffman, T Mori, EI Tuomanen, RJ Webby, H Hakim, RT Hayden, DR Hijano, W Awad, R Bajracharya, BL Clark, V Cortez, RH Dallas, T Fabrizio, P Freiden, A Gowen, J Hodges, AM Kirk, EK Roubidoux, RC Mettelman, J Russell-Bell, A Souquette, J Sparks, LA de Velde, A Vazquez-Pagan, K Whitt, TL Wilson, DE Wittman, N Wohlgemuth, G Wu
Cell Host & Microbe 2021
Elucidating T Cell and B Cell Responses to SARS-CoV-2 in Humans: Gaining Insights into Protective Immunity and Immunopathology
A Khanolkar
Cells 2021
The Pandemic Experience in Southeast Asia: Interface Between SARS-CoV-2, Malaria, and Dengue
C Yek, V Nam, R Leang, D Parker, S Heng, K Souv, S Sovannaroth, M Mayxay, S AbuBakar, R Sasmono, N Tran, H Nguyen, C Lon, K Boonnak, R Huy, L Sovann, J Manning
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Altered pre-existing SARS-CoV-2-specific T cell responses in elderly individuals
Taira N, Toguchi S, Miyagi M, Mori T, Tomori H, Oshiro K, Tamai O, Kina M, Miyagi M, Tamaki K, Collins MK, Ishikawa H
2021
The T-cell response to SARS-CoV-2: kinetic and quantitative aspects and the case for their protective role
Bertoletti A, Tan AT, Le Bert N
2021
Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination
Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U, Kern F, Schwarz T, Mangold M, Unger C, Dörfler F, Kadler S, Rosowski J, Gürcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Müller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE, Corman VM, Röhmel J, Meyer-Arndt L, Thiel A, Giesecke-Thiel C
Science (New York, N.Y.) 2021
Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers.
da Silva Antunes R, Pallikkuth S, Williams E, Yu ED, Mateus J, Quiambao L, Wang E, Rawlings SA, Stadlbauer D, Jiang K, Amanat F, Arnold D, Andrews D, Fuego I, Dan JM, Grifoni A, Weiskopf D, Krammer F, Crotty S, Hoffer ME, Pahwa SG, Sette A
medRxiv : the preprint server for health sciences 2021
Boosting of Cross-Reactive Antibodies to Endemic Coronaviruses by SARS-CoV-2 Infection but not Vaccination with Stabilized Spike.
Crowley AR, Natarajan H, Hederman AP, Bobak CA, Weiner JA, Wieland-Alter W, Lee J, Bloch EM, Tobian AAR, Redd AD, Blankson JN, Wolf D, Goetghebuer T, Marchant A, Connor RI, Wright PF, Ackerman ME
medRxiv : the preprint server for health sciences 2021
Sero-monitoring of health care workers reveals complex relationships between common coronavirus antibodies and SARS-CoV-2 severity
Gouma S, Weirick ME, Bolton MJ, Arevalo CP, Goodwin EC, Anderson EM, McAllister CM, Christensen SR, Dunbar D, Fiore D, Brock A, Weaver J, Millar J, DerOhannessian S, Frank I, Rader DJ, Wherry EJ, Hensley SE
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Identification of resident memory CD8(+) T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue.
Niessl J, Sekine T, Lange J, Konya V, Forkel M, Maric J, Rao A, Mazzurana L, Kokkinou E, Weigel W, Llewellyn-Lacey S, Hodcroft EB, Karlsson AC, Fehrm J, Sundman J, Price DA, Mjösberg J, Friberg D, Buggert M
Science Immunology 2021
Humoral Responses and Serological Assays in SARS-CoV-2 Infections
Y Galipeau, M Greig, G Liu, M Driedger, MA Langlois
Frontiers in immunology 2020
HCoV-NL63 and SARS-CoV-2 Share Recognized Epitopes by the Humoral Response in Sera of People Collected Pre- and during CoV-2 Pandemic
ER Simula, MA Manca, S Jasemi, S Uzzau, S Rubino, P Manchia, A Bitti, M Palermo, LA Sechi
Microorganisms 2020
Immunomodulation as Treatment for Severe Coronavirus Disease 2019: A Systematic Review of Current Modalities and Future Directions
EA Meyerowitz, P Sen, SR Schoenfeld, TG Neilan, MJ Frigault, JH Stone, AY Kim, MK Mansour
Clinical Infectious Diseases 2020
COVID-19—Lessons Learned and Questions Remaining
FC Fang, CA Benson, C del Rio, KM Edwards, VG Fowler, DN Fredricks, AP Limaye, BE Murray, S Naggie, PG Pappas, R Patel, DL Paterson, DA Pegues, WA Petri, RT Schooley
Clinical Infectious Diseases 2020
Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection
Anderson EM, Goodwin EC, Verma A, Arevalo CP, Bolton MJ, Weirick ME, Gouma S, McAllister CM, Christensen SR, Weaver J, Hicks P, Manzoni TB, Oniyide O, Ramage H, Mathew D, Baxter AE, Oldridge DA, Greenplate AR, Wu JE, Alanio C, D\u2019Andrea K, Kuthuru O, Dougherty J, Pattekar A, Kim J, Han N, Apostolidis SA, Huang AC, Vella LA, Wherry EJ, Meyer NJ, Cherry S, Bates P, Rader DJ, Hensley SE
2020

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