Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling
Sophie Lanone, … , Robert M. Senior, Jack A. Elias
Sophie Lanone, … , Robert M. Senior, Jack A. Elias
Published August 15, 2002
Citation Information: J Clin Invest. 2002;110(4):463-474. https://doi.org/10.1172/JCI14136.
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Article Immunology

Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling

Abstract

Research Article

Authors

Sophie Lanone, Tao Zheng, Zhou Zhu, Wei Liu, Chun Geun Lee, Bing Ma, Qingsheng Chen, Robert J. Homer, Jingming Wang, Lesley A. Rabach, Morgan E. Rabach, J. Michael Shipley, Steven D. Shapiro, Robert M. Senior, Jack A. Elias

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Figure 1

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Effect of MMP-9 and MMP-12 deficiency on IL-3–induced alterations in lun...
Effect of MMP-9 and MMP-12 deficiency on IL-3–induced alterations in lung size. CC10-rtTA-IL-13 transgene– and transgene+ mice with wild-type and null MMP-9 (top) or MMP-12 (bottom) loci were generated and placed on dox water at 1 month of age. They were maintained on this regimen for an additional month, at which time their lungs were removed, fixed to pressure, and photographed.