Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

SARS-CoV-2 viral load and antibody responses: the case for convalescent plasma therapy
Arturo Casadevall, … , Michael J. Joyner, Liise-anne Pirofski
Arturo Casadevall, … , Michael J. Joyner, Liise-anne Pirofski
Published July 7, 2020
Citation Information: J Clin Invest. 2020;130(10):5112-5114. https://doi.org/10.1172/JCI139760.
View: Text | PDF
Commentary Article has an altmetric score of 49

SARS-CoV-2 viral load and antibody responses: the case for convalescent plasma therapy

  • Text
  • PDF
Abstract

Most patients with COVID-19 lack antibody to SARS-CoV-2 in the first 10 days of illness while the virus drives disease pathogenesis. SARS-CoV-2 antibody deficiency in the setting of a tissue viral burden suggests that using an antibody as a therapeutic agent would augment the antiviral immune response. In this issue of the JCI, Wang and collaborators describe the kinetics of viral load and the antibody responses of 23 individuals with COVID-19 experiencing mild and severe disease. The researchers found that (a) individuals with mild and severe disease produced neutralizing IgG to SARS-CoV-2 10 days after disease onset, (b) SARS-CoV-2 persisted longer in those with severe disease, and (c) there was cross-reactivity between antibodies to SARS-CoV-1 and SARS-CoV-2, but only antibodies from patients with COVID-19 neutralized SARS-CoV-2. These observations provide important information on the serological response to SARS-CoV-2 of hospitalized patients with COVID-19 that can inform the use of convalescent plasma therapy.

Authors

Arturo Casadevall, Michael J. Joyner, Liise-anne Pirofski

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 Total
Citations: 1 1 3 11 18 11 45
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (45)

Title and authors Publication Year
COVID-19 convalescent plasma in immunocompromised COVID-19 patients: more certainty and clarity are added to a complex evidence base
Yoon H, Pirofski LA
eBioMedicine 2025
Single MVA-SARS-2-ST/N Vaccination Rapidly Protects K18-hACE2 Mice against a Lethal SARS-CoV-2 Challenge Infection.
Clever S, Limpinsel L, Meyer Zu Natrup C, Schünemann LM, Beythien G, Rosiak M, Hülskötter K, Gregor KM, Tuchel T, Kalodimou G, Freudenstein A, Kumar S, Baumgärtner W, Sutter G, Tscherne A, Volz A
Viruses 2024
Therapeutic equine hyperimmune antibodies with high and broad-spectrum neutralizing activity protect rodents against SARS-CoV-2 infection.
Li E, Han Q, Bi J, Wei S, Wang S, Zhang Y, Liu J, Feng N, Wang T, Wu J, Yang S, Zhao Y, Liu B, Yan F, Xia X
Frontiers in immunology 2023
Potential treatments of COVID-19: Drug repurposing and therapeutic interventions
Raghav PK, Mann Z, Ahluwalia SK, Rajalingam R
Journal of Pharmacological Sciences 2023
Exercise and Experiments of Nature.
Joyner MJ, Wiggins CC, Baker SE, Klassen SA, Senefeld JW
Comprehensive Physiology 2023
Use of Early Donated COVID-19 Convalescent Plasma Is Optimal to Preserve the Integrity of Lymphatic Endothelial Cells
N Amri, R Bégin, N Tessier, L Vachon, L Villeneuve, P Bégin, R Bazin, L Loubaki, C Martel
Pharmaceuticals (Basel, Switzerland) 2022
Increased Antibody Avidity and Cross-Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Variants by Hyperimmunized Transchromosomic Bovine–Derived Human Immunoglobulins for Treatment of Coronavirus Disease 2019
Tang J, Grubbs G, Lee Y, Wu H, Luke TC, Egland KA, Bausch CL, Sullivan EJ, Khurana S
The Journal of Infectious Diseases 2022
Memory B cells and serum immunoglobulins are associated with disease severity and mortality in patients with COVID-19
Çölkesen F, Kepenek Kurt E, Vatansev H, Korkmaz C, Çölkesen F, Yücel F, Yıldız E, Evcen R, Aykan FS, Kılınç M, Aytekin G, Feyzioğlu B, Doğan M, Arslan Ş, Teke T, Keleş S, Reisli İ
Postgraduate medical journal 2022
Advances in Pathogenesis, Progression, Potential Targets and Targeted Therapeutic Strategies in SARS-CoV-2-Induced COVID-19
Zhou H, Ni WJ, Huang W, Wang Z, Cai M, Sun YC
Frontiers in immunology 2022
Equine immunoglobulin fragment F(ab’)2 displays high neutralizing capability against multiple SARS-CoV-2 variants
Gupta D, Ahmed F, Tandel D, Parthasarathy H, Vedagiri D, Sah V, Krishna Mohan B, Khan RA, Kondiparthi C, Savari P, Jain S, Reddy S, Kumar JM, Khan N, Harshan KH
Clinical Immunology 2022
Dysregulation of immunity in COVID-19 and SLE.
Hejazian SS, Hejazian SM, Farnood F, Abedi Azar S
InflammoPharmacology 2022
Early COVID-19 respiratory risk stratification using machine learning.
Douglas MJ, Bell BW, Kinney A, Pungitore SA, Toner BP
2022
Autoimmune and immunoserological markers of COVID-19 pneumonia: Can they help in the assessment of disease severity
Stjepanovic MI, Stojanovic MR, Stankovic S, Cvejic J, Dimic-Janjic S, Popevic S, Buha I, Belic S, Djurdjevic N, Stjepanovic MM, Jovanovic D, Stojkovic-Laloševic M, Soldatovic I, Bonaci-Nikolic B, Miskovic R
Frontiers in Medicine 2022
Challenges in the Detection of SARS-CoV-2: Evolution of the Lateral Flow Immunoassay as a Valuable Tool for Viral Diagnosis
Castrejón-Jiménez NS, García-Pérez BE, Reyes-Rodríguez NE, Vega-Sánchez V, Martínez-Juárez VM, Hernández-González JC
Biosensors 2022
COVID-19 convalescent plasma therapy through the lens of the third year of the pandemic.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2022
The clinical outcomes of high neutralizing antibodies titer convalescent plasma therapy in early developed severe COVID-19 patients; a case-control study.
Nontawong N, Siripongboonsitti T, Tawinprai K, Boonpratoom M, Krailassiri N, Boonkhum C, Soonklang K, Poovorawan Y, Mahanonda N
Annals of clinical microbiology and antimicrobials 2022
Clinical and laboratory evaluation of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma
Michele Donato, Steven Park, Melissa Baker, Robert Korngold, Alison Morawski, Xue Geng, Ming Tan, Andrew Ip, Stuart Goldberg, Scott D. Rowley, Kar F Chow, Emily Brown, Joshua Zenreich, Phyllis McKiernan, Kathryn Buttner, Anna Ullrich, Laura Long, Rena Feinman, Andrea Ricourt, Marlo Kemp, Mariefel Vendivil, Hyung C. Suh, Bindu Balani, Cristina Cicogna, Rani Sebti, Abdulla Al-Khan, Steven J. Sperber, Samit Desai, Stacey L. Fanning, Danit Arad, Ronaldo C. Go, Elizabeth Tam, Keith Rose, Sean Sadikot, David S Siegel, Martin Gutierrez, Tatyana Feldman, Andre Goy, Andrew Pecora, Noa Biran, Lori A. Leslie, Alfred Gillio, Sarah Timmapuri, Michele S. Boonstra, Sam Singer, Sukhdeep Kaur, Ernest Richards, David S Perlin
JCI Insight 2021
COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects
DM Smadja, SJ Mentzer, M Fontenay, MA Laffan, M Ackermann, J Helms, D Jonigk, R Chocron, GB Pier, N Gendron, S Pons, JL Diehl, C Margadant, C Guerin, EJ Huijbers, A Philippe, N Chapuis, P Nowak-Sliwinska, C Karagiannidis, O Sanchez, P Kümpers, D Skurnik, AM Randi, AW Griffioen
Angiogenesis 2021
Disease Severity and Durability of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Response: A View Through the Lens of the Second Year of the Pandemic
L Pirofski
Clinical Infectious Diseases 2021
Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response
JD Herman, C Wang, C Loos, H Yoon, J Rivera, ME Dieterle, D Haslwanter, RK Jangra, RH Bortz, KJ Bar, B Julg, K Chandran, D Lauffenburger, L Pirofski, G Alter
Nature Communications 2021
Characterization of SARS-CoV-2-specific humoral immunity and its potential applications and therapeutic prospects
J Zheng, Y Deng, Z Zhao, B Mao, M Lu, Y Lin, A Huang
Cellular and Molecular Immunology 2021
Convalescent Plasma for the Prevention and Treatment of COVID-19: A Systematic Review and Quantitative Analysis
HT Peng, SG Rhind, A Beckett
2021
Use of convalescent plasma for COVID-19 in India: A review & practical guidelines
NS Khaire, N Jindal, LN Yaddanapudi, S Sachdev, R Hans, N Sachdeva, MP Singh, A Agarwal, A Mukherjee, G Kumar, RR Sharma, V Suri, GD Puri, P Malhotra
The Indian journal of medical research 2021
Randomized controlled trial of convalescent plasma therapy against standard therapy in patients with severe COVID-19 disease
M AlQahtani, A Abdulrahman, A Almadani, SY Alali, AM Zamrooni, AH Hejab, RM Conroy, P Wasif, S Otoom, SL Atkin, M Abduljalil
Scientific Reports 2021
Rapid and Flexible Platform To Assess Anti-SARS-CoV-2 Antibody Neutralization and Spike Protein-Specific Antivirals
D Stelitano, SP Weisberg, MP Goldklang, Y Zhu, FT Bovier, GF Kalantarov, G Greco, D Decimo, G Franci, M Cennamo, G Portella, M Galdiero, C Mathieu, B Horvat, IN Trakht, A Moscona, MA Whitt, M Porotto, R Dutch
mSphere 2021
The Case for S2: The Potential Benefits of the S2 Subunit of the SARS-CoV-2 Spike Protein as an Immunogen in Fighting the COVID-19 Pandemic
P Shah, GA Canziani, EP Carter, I Chaiken
Frontiers in immunology 2021
Impact of Convalescent Plasma Therapy on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Profile in Coronavirus Disease 2019 (COVID-19) Patients
Tang J, Grubbs G, Lee Y, Golding H, Khurana S
Clinical Infectious Diseases 2021
Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients
Tang J, Ravichandran S, Lee Y, Grubbs G, Coyle EM, Klenow L, Genser H, Golding H, Khurana S
Nature Communications 2021
Longitudinal antibody repertoire in “mild” versus “severe” COVID-19 patients reveals immune markers associated with disease severity and resolution
Ravichandran S, Lee Y, Grubbs G, Coyle EM, Klenow L, Akasaka O, Koga M, Adachi E, Saito M, Nakachi I, Ogura T, Baba R, Ito M, Kiso M, Yasuhara A, Yamada S, Sakai-Tagawa Y, Iwatsuki-Horimoto K, Imai M, Yamayoshi S, Yotsuyanagi H, Kawaoka Y, Khurana S
Science Advances 2021
Rapid immunoassay and clinical evaluation of the SARS‐CoV‐2 antibody assay on the real express‐6 analyzer
Zhang S, Ning Y, Rong Y, Nie Y, Xiong Z, Li R, Jin T, Cai T
Journal of Medical Virology 2021
COVID-19 Repeated Convalescent Plasma Collection: Analysis of 149 Donations from 88 French Military Health Workers
Conan PL, Ficko C, Chueca M, Rolland C, Javaudin O, Bigaillon C, Durand GA, Leparc-Goffart I, Verret C, Aletti M, Dutasta F, Savini H, Bosson JL, Martinaud C
Transfusion Medicine and Hemotherapy 2021
Convalescent Plasma Therapy in the management of COVID-19 patients-The newer dimensions
Mahapatra S, Rattan R, Mohanty CB
Transfusion Clinique et Biologique 2021
Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern
Tang J, Lee Y, Ravichandran S, Grubbs G, Huang C, Stauft CB, Wang T, Golding B, Golding H, Khurana S
iScience 2021
Implications of Coronavirus Disease 2019 (COVID-19) Antibody Dynamics for Immunity and Convalescent Plasma Therapy.
Casadevall A, Joyner MJ, Pirofski LA
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021
The role of IgG Fc receptors in antibody-dependent enhancement
S Bournazos, A Gupta, JV Ravetch
Nature Reviews Immunology 2020
The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19)
N Batra, CD Souza, J Batra, AG Raetz, AM Yu
International journal of molecular sciences 2020
Pharmaco-Immunomodulatory Therapy in COVID-19
JG Rizk, K Kalantar-Zadeh, MR Mehra, CJ Lavie, Y Rizk, DN Forthal
Drugs 2020
COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice
J Zheng, LY Wong, K Li, AK Verma, ME Ortiz, C Wohlford-Lenane, MR Leidinger, CM Knudson, DK Meyerholz, PB McCray, S Perlman
Nature 2020
The Assessment of Convalescent Plasma Efficacy against COVID-19
A Casadevall, BJ Grossman, JP Henderson, MJ Joyner, S Shoham, L Pirofski, N Paneth
The American Journal of Medicine 2020
Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial)
Agarwal A, Mukherjee A, Kumar G, Chatterjee P, Bhatnagar T, Malhotra P, Agarwal A, Mukherjee A, Kumar G, Chatterjee P, Bhatnagar T, Malhotra P, Latha B, Bundas S, Kumar V, Dosi R, Khambholja JK, de Souza R, Mesipogu RR, Srivastava S, Dube S, Chaudhary K, Subash S, Anbuselvi S, Rajendran V, Sundararajaperumal A, Balamanikandan P, Maheswari RS, Jayanthi R, Ragunanthanan S, Bhandari S, Singh A, Pal A, Handa A, Rankawat G, Kargirwar K, Regi J, Rathod D, Pathrose E, Bhutaka N, Patel MH, Verma RJ, Malukani K, Patel S, Thakur A, Joshi S, Kulkarni R, Suthar NN, Shah NM, Purohit HM, Shah CK, Patel MN, Shah S, Shah ST, Memon T, Beriwala VR, Jashnani K, Ezzy F, Agrawal S, Bhadade R, Atish M, Madke T, Kavishwar V, Waghmare R, Valvi N, Chander BT, Sekhar AV, Maurya AK, Hemanth K, Nagamani K, Sudha K, Chandra TR, Rao KT, Vyshnavi J, Upadhyay R, Bahadur S, Pathak R, Seth S, Gupta R, Saxena R, Dwivedi P, Malik R, Chourasia D, Lalwani J, Sharma U, Marko J, Suri A, Kumar V, Kaushik R, Kodan P, Acharya BP, Gaur KK, Gupta A, Sachdeva P, Dogra S, Jindal A, John MJ, Dhanju AS, Khetrepal R, Sharma N, Kukar N, Kavita D, Kumar R, Mahajan R, Singh G, Kaur J, Singh RP, Bassi R, Parikh S, Shrivastav O, Shastri J, Desai M, Udupa S, Bafna VA, Barge V, Madane R, Yadav S, Misra S, Bajpayee A, Garg MK, Bohra GK, Nag V, Anne PB, Nadeem M, Singh P, Niwas R, Khaire NS, Sharma R, Singh MP, Sachdeva N, Sachdev S, Hans R, Suri V, Yaddanapudi L, Lakshmi P, Singh N, Bhushan D, Kumar N, Tambe M, Salvi S, Kadgi N, Sangle S, Nakate L, Joshi S, Karyakarte R, Goyanka S, Sharma N, Verma N, Das A, Bahl M, Wadhwa N, Bhat S, Deshmukh S, Wagh V, Kulkarni A, Yardi T, Kalgud RS, Reddy P, Yevoor K, Gajula P, Maleyur V, Medini S, Mohith H, Gurtoo A, Sud R, Pahuja S, Prakash A, Gogoi P, Shukla S, Reddy DH, Chandra T, Pandey S, Maurya P, Ali W, Kumar V, Upadhyay K, Bhatnagar N, Shah N, Shah M, Patel T, Jaiswal RM, Jain A, Sharma S, Rijhwani P, Gupta N, Patel TC, Solu MG, Patel J, Shah YR, Jarag M, Godbole V, Shah M, Raj R, Nagori I, Jha PR, Shah AD, Yeeli G, Jain A, Gill RK, Babu KS, Babu BS, Mohan A, Vengamma B, Sekhar KC, Damam S, Narsimhulu K, Aparna C, Baleswari G, Reddy KR, Chandrasekhar P, Panjwani SJ, Shah PH, Barvaliya M, Desai K, Akholkar PJ, Baldi M, Yadav A, Gupta M, Rawat N, Chawda D, Natarajan M, Sintha M, Kumar DP, Rabbani F, Khadke VK, Patki D, Marathe S, D\u2019Souza C, Tadha V, Arora S, Gupta DK, Dua S, Chauhan N, Chahar AS, Mammen JJ, Kumar S, Daniel D, Singh R, Dhat V, Agarwal Y, Arora S, Pathak A, Purohit M, Sharma A, Sharma J, Madkaikar M, Joshi K, Yadav RM, Bhagwat S, Karnik ND, Gokhale YA, Naik L, Margam S, Das S, Turuk A, Kumar VS, Kanagasabai K, Sabarinathan R, Deshpande G, Sharma S, Gunjikar R, Shete A, Phagiwala D, Patil C, Shingade S, Jarande K, Kaushal H, Yadav P, Sapkal G, Abraham P
2020
Rapid Antibody-Based COVID-19 Mass Surveillance: Relevance, Challenges, and Prospects in a Pandemic and Post-Pandemic World
Augustine R, Das S, Hasan A, S A, Abdul Salam S, Augustine P, Dalvi YB, Varghese R, Primavera R, Yassine HM, Thakor AS, Kevadiya BD
Journal of Clinical Medicine 2020
Correlates of Protection Against SARS-CoV-2 in Rhesus Macaques
McMahan K, Yu J, Mercado NB, Loos C, Tostanoski LH, Chandrashekar A, Liu J, Peter L, Atyeo C, Zhu A, Bondzie EA, Dagotto G, Gebre MS, Jacob-Dolan C, Li Z, Nampanya F, Patel S, Pessaint L, Van Ry A, Blade K, Yalley-Ogunro J, Cabus M, Brown R, Cook A, Teow E, Andersen H, Lewis MG, Lauffenburger DA, Alter G, Barouch DH
Nature 2020
Compassionate use of convalescent plasma for treatment of moderate and severe pneumonia in COVID-19 patients and association with IgG antibody levels in donated plasma
Maor Y, Cohen D, Paran N, Israely T, Ezra V, Axelrod O, Shinar E, Izak M, Rahav G, Rahimi-Levene N, Bazofin BM, Gelman R, Dicker D, Brosh-Nissimov T, Megged O, Dahan D, Benov A, Paz A, Edward K, Moran A, Rogowski O, Sorkine P, Mayo A, Zimhony O, Chen J
2020
Optimization of hydroxychloroquine dosing scheme based on COVID-19 patients' characteristics: a review of the literature and simulations.
Karatza E, Ismailos G, Marangos M, Karalis V
Xenobiotica; the fate of foreign compounds in biological systems 2020
Evidence lags behind excitement over blood plasma as a coronavirus treatment.
Ledford H
Nature 2020

← Previous 1 2 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Picked up by 1 news outlets
Posted by 65 X users
On 2 Facebook pages
128 readers on Mendeley
See more details