Usage Information

Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts.
Y Srinivasan, … , F J Lovicu, P A Overbeek
Y Srinivasan, … , F J Lovicu, P A Overbeek
Published February 1, 1998
Citation Information: J Clin Invest. 1998;101(3):625-634. https://doi.org/10.1172/JCI1360.
View: Text | PDF
Research Article Article has an altmetric score of 6

Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts.

Abstract

Transgenic mice were generated by microinjection of a construct containing a self-activating human TGF-beta1 cDNA driven by the lens-specific alphaA-crystallin promoter. Seven transgenic founder mice were generated, and four transgenic lines expressing TGF-beta1 were characterized. By postnatal day 21, mice from the four families exhibited anterior subcapsular cataracts. The lenses in these mice developed focal plaques of spindle-shaped cells that expressed alpha-smooth muscle actin, and that resembled the plaques seen in human anterior subcapsular cataracts. Transgenic mice showed additional ocular defects, including corneal opacification and structural changes in the iris and ciliary body. The corneal opacities were associated with increased exfoliation of the squamous layer of the corneal epithelium and increased DNA replication in the basal epithelium.

Authors

Y Srinivasan, F J Lovicu, P A Overbeek

×

Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 189 30
PDF 47 29
Citation downloads 53 0
Totals 289 59
Total Views 348
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement