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Usage Information

Neuroimmune modulation of pain and regenerative pain medicine
Thomas Buchheit, … , Jianguo Cheng, Ru-Rong Ji
Thomas Buchheit, … , Jianguo Cheng, Ru-Rong Ji
Published April 6, 2020
Citation Information: J Clin Invest. 2020;130(5):2164-2176. https://doi.org/10.1172/JCI134439.
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Review Article has an altmetric score of 19

Neuroimmune modulation of pain and regenerative pain medicine

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Abstract

Regenerative pain medicine, which seeks to harness the body’s own reparative capacity, is rapidly emerging as a field within pain medicine and orthopedics. It is increasingly appreciated that common analgesic mechanisms for these treatments depend on neuroimmune modulation. In this Review, we discuss recent progress in mechanistic understanding of nociceptive sensitization in chronic pain with a focus on neuroimmune modulation. We also examine the spectrum of regenerative outcomes, including preclinical and clinical outcomes. We further distinguish the analgesic mechanisms of regenerative therapies from those of cellular replacement, creating a conceptual and mechanistic framework to evaluate future research on regenerative medicine.

Authors

Thomas Buchheit, Yul Huh, William Maixner, Jianguo Cheng, Ru-Rong Ji

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 1,106 204
PDF 139 63
Figure 223 1
Table 134 0
Citation downloads 87 0
Totals 1,689 268
Total Views 1,957
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