Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways
Charles N. Serhan, Ernst Oliw
Charles N. Serhan, Ernst Oliw
Published June 15, 2001
Citation Information: J Clin Invest. 2001;107(12):1481-1489. https://doi.org/10.1172/JCI13375.
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Biosynthesis of 19R-hydroxy-PGE from PGH2 by CYP4F8 and PGE synthases. 1...
Biosynthesis of 19R-hydroxy-PGE from PGH2 by CYP4F8 and PGE synthases. 19R-hydroxy-PGE is a major eicosanoid in humans. This novel biosynthesis route indicates that the 19 position R alcohol is in place before the PGE2 ring is made (see text).