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Citations to this article

A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation.
C M Rodrigues, … , B T Kren, C J Steer
C M Rodrigues, … , B T Kren, C J Steer
Published June 15, 1998
Citation Information: J Clin Invest. 1998;101(12):2790-2799. https://doi.org/10.1172/JCI1325.
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A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation.

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Abstract

The hydrophilic bile salt ursodeoxycholic acid (UDCA) protects against the membrane-damaging effects associated with hydrophobic bile acids. This study was undertaken to (a) determine if UDCA inhibits apoptosis from deoxycholic acid (DCA), as well as from ethanol, TGF-beta1, Fas ligand, and okadaic acid; and to (b) determine whether mitochondrial membrane perturbation is modulated by UDCA. DCA induced significant hepatocyte apoptosis in vivo and in isolated hepatocytes determined by terminal transferase-mediated dUTP-digoxigenin nick end-labeling assay and nuclear staining, respectively (P < 0.001). Apoptosis in isolated rat hepatocytes increased 12-fold after incubation with 0.5% ethanol (P < 0.001). HuH-7 cells exhibited increased apoptosis with 1 nM TGF-beta1 (P < 0. 001) or DCA at >/= 100 microM (P < 0.001), as did Hep G2 cells after incubation with anti-Fas antibody (P < 0.001). Finally, incubation with okadaic acid induced significant apoptosis in HuH-7, Saos-2, Cos-7, and HeLa cells. Coadministration of UDCA with each of the apoptosis-inducing agents was associated with a 50-100% inhibition of apoptotic changes (P < 0.001) in all the cell types. Also, UDCA reduced the mitochondrial membrane permeability transition (MPT) in isolated mitochondria associated with both DCA and phenylarsine oxide by > 40 and 50%, respectively (P < 0.001). FACS(R) analysis revealed that the apoptosis-inducing agents decreased the mitochondrial transmembrane potential and increased reactive oxygen species production (P < 0.05). Coadministration of UDCA was associated with significant prevention of mitochondrial membrane alterations in all cell types. The results suggest that UDCA plays a central role in modulating the apoptotic threshold in both hepatocytes and nonliver cells, and inhibition of MPT is at least one pathway by which UDCA protects against apoptosis.

Authors

C M Rodrigues, G Fan, X Ma, B T Kren, C J Steer

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Journal of Hepatology 2015
Autoimmune hepatitis-primary biliary cirrhosis concurrent with biliary stricture after liver transplantation
Yong-Zhen Kang, Xiao-Ye Sun, Yi-He Liu, Zhong-Yang Shen
World journal of gastroenterology : WJG 2015
Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties
T Sousa, RE Castro, SN Pinto, A Coutinho, SD Lucas, R Moreira, CM Rodrigues, M Prieto, F Fernandes
Journal of lipid research 2015
Autoimmune hepatitis-primary biliary cirrhosis concurrent with biliary stricture after liver transplantation
YZ Kang, XY Sun, YH Liu, ZY Shen
World journal of gastroenterology : WJG 2015
Tauroursodeoxycholic Acid, a Bile Acid, Promotes Blood Vessel Repair by Recruiting Vasculogenic Progenitor Cells
JG Cho, JH Lee, SH Hong, HN Lee, CM Kim, SY Kim, KJ Yoon, BJ Oh, JH Kim, SY Jung, T Asahara, SM Kwon, SG Park
2014
Molecular mechanisms of hepatic apoptosis
K Wang
Cell Death and Disease 2014
c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver
DM Ferreira, MB Afonso, PM Rodrigues, AL Simão, DM Pereira, PM Borralho, CM Rodrigues, RE Castro
Molecular and cellular biology 2014
Ursodeoxycholic acid influences the expression of p27kip1 but not FoxO1 in patients with non-cirrhotic primary biliary cirrhosis
M Milkiewicz, J Kopycińska, A Kempińska-Podhorodecka, T Haas, DP Bogdanos, E Elias, P Milkiewicz
Journal of Immunology Research 2014
Ursodeoxycholic acid decreases bilirubin-induced osteoblast apoptosis
S Ruiz-Gaspà, M Dubreuil, N Guañabens, A Combalia, P Peris, A Monegal, A Parés
European Journal of Clinical Investigation 2014
Unfolded protein response prevents blastocyst formation during preimplantation embryo development in vitro
M Basar, I Bozkurt, O Guzeloglu-Kayisli, B Sozen, I Tekmen, F Schatz, A Arici, CJ Lockwood, UA Kayisli
Fertility and Sterility 2014
Prospective Randomized Trial of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid for Prevention of Radiation-Induced Liver Toxicity
M Seidensticker, R Seidensticker, R Damm, K Mohnike, M Pech, B Sangro, P Hass, P Wust, S Kropf, G Gademann, J Ricke, V Wong
PloS one 2014
The therapeutic potential of chemical chaperones in protein folding diseases
L Cortez, V Sim
Prion 2014
Hepatolithiasis: analysis of Japanese nationwide surveys over a period of 40 years
Y Suzuki, T Mori, M Yokoyama, T Nakazato, N Abe, Y Nakanuma, H Tsubouchi, M Sugiyama
Journal of Hepato-Biliary-Pancreatic Sciences 2014
Synbiotics: the impact of potential prebiotics inulin, lactulose and lactobionic acid on the survival and growth of lactobacilli probiotics
OO Adebola, O Corcoran, WA Morgan
Journal of Functional Foods 2014
Three Measurable and Modifiable Enteric Microbial Biotransformations Relevant to Cancer Prevention and Treatment
GA Plotnikoff
Global Advances in Health and Medicine 2014
Silencing of the hTERT Gene by shRNA Inhibits Colon Cancer SW480 Cell Growth In Vitro and In Vivo
AQ Liu, LY Ge, XL Lu, XL Luo, YL Cai, XQ Ye, FF Geng, A Ahmad
PloS one 2014
Ursodeoxycholic Acid Ameliorates Apoptotic Cascade in the Rotenone Model of Parkinson’s Disease: Modulation of Mitochondrial Perturbations
NF Abdelkader, MM Safar, HA Salem
Molecular Neurobiology 2014
The therapeutic potential of chemical chaperones in protein folding diseases.
Cortez L, Sim V
Prion 2014
Comprehensive Physiology
LJ Dixon, M Barnes, H Tang, MT Pritchard, LE Nagy
Comprehensive Physiology 2013
Comprehensive Physiology
LJ Dixon, M Barnes, H Tang, MT Pritchard, LE Nagy
Comprehensive Physiology 2013
Comprehensive Physiology
LJ Dixon, M Barnes, H Tang, MT Pritchard, LE Nagy
Comprehensive Physiology 2013
Comprehensive Physiology
LJ Dixon, M Barnes, H Tang, MT Pritchard, LE Nagy
Comprehensive Physiology 2013
Comprehensive Physiology
LJ Dixon, M Barnes, H Tang, MT Pritchard, LE Nagy
Comprehensive Physiology 2013
Comprehensive Physiology
LJ Dixon, M Barnes, H Tang, MT Pritchard, LE Nagy
Comprehensive Physiology 2013
Interventions for treating cholestasis in pregnancy
V Gurung, M Stokes, P Middleton, SJ Milan, W Hague, JG Thornton
Cochrane Database of Systematic Reviews 2013
An updated review on drug-induced cholestasis: Mechanisms and investigation of physicochemical properties and pharmacokinetic parameters
K Yang, K Köck, A Sedykh, A Tropsha, KL Brouwer
Journal of Pharmaceutical Sciences 2013
Protective effects of prebiotics inulin and lactulose from cytotoxicity and genotoxicity in human colon adenocarcinoma cells
O Adebola, O Corcoran, WA Morgan
Food Research International 2013
Non-alcoholic steatohepatitis in morbidly obese patients
A Tran, P Gual
Clinics and Research in Hepatology and Gastroenterology 2013
Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations
J Mello-Vieira, T Sousa, A Coutinho, A Fedorov, SD Lucas, R Moreira, RE Castro, CM Rodrigues, M Prieto, F Fernandes
Biochimica et Biophysica Acta (BBA) - Biomembranes 2013
Role of glucuronidation for hepatic detoxification and urinary elimination of toxic bile acids during biliary obstruction
M Perreault, A Białek, J Trottier, M Verreault, P Caron, P Milkiewicz, O Barbier
PloS one 2013
Regulation of basal lateral membrane mobility and permeability to divalent cations by membrane associated-protein kinase C
C Zhang, Y Zheng, L Chen, M Chen, S Liang, M Lin, D Luo
PloS one 2013
Alcohol Consumption Decreases Rat Hepatic Creatine Biosynthesis Via Altered Guanidinoacetate Methyltransferase Activity
KK Kharbanda, SL Todero, JC Moats, RM Harris, NA Osna, PG Thomes, DJ Tuma
Alcoholism Clinical and Experimental Research 2013
Regulation of Basal Lateral Membrane Mobility and Permeability to Divalent Cations by Membrane Associated-Protein Kinase C
C Zhang, Y Zheng, L Chen, M Chen, S Liang, M Lin, D Luo, D Holowka
PloS one 2013
Role of Glucuronidation for Hepatic Detoxification and Urinary Elimination of Toxic Bile Acids during Biliary Obstruction
M Perreault, A Białek, J Trottier, M Verreault, P Caron, P Milkiewicz, O Barbier, MA Avila
PloS one 2013
Higher Fecal Bile Acid Hydrophobicity Is Associated with Exacerbation of Dextran Sodium Sulfate Colitis in Mice
LK Stenman, R Holma, R Forsgård, H Gylling, R Korpela
The Journal of nutrition 2013
Prevention of acute kidney injury by tauroursodeoxycholic acid in rat and cell culture models
S Gupta, S Li, MJ Abedin, K Noppakun, L Wang, T Kaur, B Najafian, CM Rodrigues, CJ Steer
PloS one 2012
The Immunophysiology and Apoptosis of Biliary Epithelial Cells: Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis
K Kawata, Y Kobayashi, ME Gershwin, CL Bowlus
Clinical Reviews in Allergy & Immunology 2012
Novel insight into mechanisms of cholestatic liver injury
BL Woolbright, H Jaeschke
World journal of gastroenterology : WJG 2012
Molecular Mechanisms of Ursodeoxycholic Acid Toxicity & Side Effects: Ursodeoxycholic Acid Freezes Regeneration & Induces Hibernation Mode
MA Kotb
International journal of molecular sciences 2012
Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation
R Cursio, J Gugenheim
Journal of Transplantation 2012
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz
Protein Engineering for Therapeutics Part B 2012
Damage to mtDNA in liver injury of patients with extrahepatic cholestasis: The protective effects of mitochondrial transcription factor A
SC Xu, YB Chen, H Lin, HF Pi, NX Zhang, CC Zhao, L Shuai, M Zhong, ZP Yu, Z Zhou, P Bie
Free radical biology & medicine 2012
The Liver and Parenteral Nutrition
KM Khan, NC Kumar, RW Gruessner
Zakim and Boyer s Hepatology 2012
Ursodeoxycholic Acid Protects Colon Cancer HCT116 Cells From Deoxycholic Acid-Induced Apoptosis by Inhibiting Apoptosome Formation
T Saeki, S Yui, T Hirai, T Fujii, S Okada, R Kanamoto
Nutrition and Cancer 2012
Tauroursodeoxycholic Acid Prevents MPTP-Induced Dopaminergic Cell Death in a Mouse Model of Parkinson’s Disease
M Castro-Caldas, AN Carvalho, E Rodrigues, CJ Henderson, CR Wolf, CM Rodrigues, MJ Gama
Molecular Neurobiology 2012
Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice
AC Lo, Z Callaerts-Vegh, AF Nunes, CM Rodrigues, R D'Hooge
Neurobiology of Disease 2012
Bile acids: From digestion to cancers
M Baptissart, A Vega, S Maqdasy, F Caira, S Baron, JM Lobaccaro, DH Volle
Biochimie 2012
Possible mechanisms underlying the biphasic regulatory effects of arachidonic acid on Ca2+ signaling in HEK293 cells
L Chen, Q Meng, X Yu, C Li, C Zhang, C Cui, D Luo
Cellular Signalling 2012
Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice
RM Ramalho, AF Nunes, RB Dias, JD Amaral, AC Lo, R D'Hooge, AM Sebastião, CM Rodrigues
Neurobiology of Aging 2012
miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
RE Castro, DM Ferreira, MB Afonso, PM Borralho, MV Machado, H Cortez-Pinto, CM Rodrigues
Journal of Hepatology 2012
Treatment of NASH with ursodeoxycholic acid: Pro
V Ratziu
Clinics and Research in Hepatology and Gastroenterology 2012
Primary biliary cirrhosis and bile acids
C Corpechot
Clinics and Research in Hepatology and Gastroenterology 2012
Treatment of NASH with ursodeoxycholic acid: Cons
F Liechti, JF Dufour
Clinics and Research in Hepatology and Gastroenterology 2012
The Nicotinamide Adenine Dinucleotide Phosphate Oxidase Homologues NOX1 and NOX2/gp91phox Mediate Hepatic Fibrosis in Mice
YH Paik, K Iwaisako, E Seki, S Inokuchi, B Schnabl, CH Osterreicher, T Kisseleva, DA Brenner
Hepatology 2011
Tauroursodeoxycholic Acid (TUDCA) Protects Photoreceptors from Cell Death after Experimental Retinal Detachment
D Mantopoulos, Y Murakami, J Comander, A Thanos, M Roh, JW Miller, DG Vavvas
PloS one 2011
The role of the innate immune recognition system in the pathogenesis of primary biliary cirrhosis: a conceptual view
PA Berg
Liver International 2011
Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications
MG Roma, FD Toledo, AC Boaglio, CL Basiglio, FA Crocenzi, EJ Sánchez Pozzi
Clinical Science 2011
Comparison of different bile acid-phospholipid conjugates in acute hepatitis
A Pathil, A Warth, W Chamulitrat, W Stremmel
European Journal of Clinical Investigation 2011
A role for protein kinase C in the regulation of membrane fluidity and Ca2+ flux at the endoplasmic reticulum and plasma membranes of HEK293 and Jurkat cells
L Chen, Q Meng, X Jing, P Xu, D Luo
Cellular Signalling 2011
Nitric oxide mimics transcriptional and post-translational regulation during α-Tocopherol cytoprotection against glycochenodeoxycholate-induced cell death in hepatocytes
R González, A Cruz, G Ferrín, P López-Cillero, R Fernández-Rodríguez, J Briceño, MA Gómez, S Rufián, MD la Mata, A Martínez-Ruiz, JJ Marin, J Muntané
Journal of Hepatology 2011
Ursodeoxycholic acid treatment of hepatic steatosis: a 13C NMR metabolic study
PM Nunes, JG Jones, AP Rolo, CM Palmeira, RA Carvalho
NMR in Biomedicine 2011
A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis
V Ratziu, V Ledinghen, F Oberti, P Mathurin, C Wartelle-Bladou, C Renou, P Sogni, M Maynard, D Larrey, L Serfaty, D Bonnefont-Rousselot, JP Bastard, M Rivière, J Spénard
Journal of Hepatology 2011
Meta-analysis: ursodeoxycholic acid for primary sclerosing cholangitis
CK Triantos, NM Koukias, VN Nikolopoulou, AK Burroughs
Alimentary Pharmacology & Therapeutics 2011
The protective effects of ursodeoxycholic acid on isoniazid plus rifampicin induced liver injury in mice
X Chen, J Xu, C Zhang, T Yu, H Wang, M Zhao, ZH Duan, Y Zhang, JM Xu, DX Xu
European Journal of Pharmacology 2011
Alternative therapeutic advantages of catfish bile on atopic dermatitis: protection of T cell-mediated skin disease via antioxidant activities
DI Lee, YJ Huh, KW Hwang, YW Choi, JS Choi, SY Han, YS Gyoung, SS Joo
Journal of Pharmacy and Pharmacology 2011
Mechanisms of Liver Injury
H Malhi, GJ Gores
Schiff s Diseases of the Liver Schiff/Schiff s Diseases of the Liver 2011
cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase
A Johnston, K Ponzetti, MS Anwer, CR Webster
AJP Gastrointestinal and Liver Physiology 2011
Bile Acids Induce Inflammatory Genes in Hepatocytes
K Allen, H Jaeschke, BL Copple
The American Journal of Pathology 2011
Neuronal loss in the rostral ventromedial medulla in a rat model of neuropathic pain
ML Leong, M Gu, R Speltz-Paiz, EI Stahura, N Mottey, CJ Steer, M Wessendorf
Journal of Neuroscience 2011
Tauroursodeoxycholic Acid Enhances the Pre-Implantation Embryo Development by Reducing Apoptosis in Pigs : TUDCA Enhances Porcine Embryo Development
JS Kim, BS Song, KS Lee, DH Kim, SU Kim, YK Choo, KT Chang, DB Koo
Reproduction in Domestic Animals 2011
Fetal and Neonatal Physiology
LH Johnson, VK Bhutani
Fetal and Neonatal Physiology 2011
Schiff's Diseases of the Liver: Schiff/Schiff's Diseases of the Liver
H Malhi, GJ Gores
Schiff's Diseases of the Liver: Schiff/Schiff's Diseases of the Liver 2011
High-dose ursodeoxycholic acid increases risk of adverse outcomes in patients with early stage primary sclerosing cholangitis
MH Imam, E Sinakos, AA Gossard, KV Kowdley, VA Luketic, ME Harrison, T McCashland, AS Befeler, D Harnois, R Jorgensen, J Petz, J Keach, AC DeCook, F Enders, KD Lindor
Alimentary Pharmacology and Therapeutics 2011
Isolation of Primary Human Hepatocytes from Normal and Diseased Liver Tissue: A One Hundred Liver Experience
RH Bhogal, J Hodson, DC Bartlett, CJ Weston, SM Curbishley, E Haughton, KT Williams, GM Reynolds, PN Newsome, DH Adams, SC Afford, N Wong
PloS one 2011
Therapeutic effects of the novel bile acid-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) in acute liver injury
Anita Pathil, Arne Warth, Walee Chamulitrat, Wolfgang Stremmel
Journal of Hepatology 2010
Hepatocyte death: a clear and present danger
H Malhi, ME Guicciardi, GJ Gores
Physiological reviews 2010
Changes in Hepatic Gene Expression upon Oral Administration of Taurine-Conjugated Ursodeoxycholic Acid in ob/ob Mice
JS Yang, JT Kim, J Jeon, HS Park, GH Kang, KS Park, HK Lee, S Kim, YM Cho, TI Sorensen
PloS one 2010
A pilot trial of high-dose ursodeoxycholic acid in nonalcoholic steatohepatitis
LA Adams, P Angulo, J Petz, J Keach, KD Lindor
Hepatology International 2010
Novel treatment modalities for nonalcoholic steatohepatitis
SK Satapathy, AJ Sanyal
Trends in Endocrinology & Metabolism 2010
Bile acid changes after high-dose ursodeoxycholic acid treatment in primary sclerosing cholangitis: Relation to disease progression
E Sinakos, HU Marschall, KV Kowdley, A Befeler, J Keach, K Lindor
Hepatology 2010
Bile salts and cholestasis
LM de Wenniger, U Beuers
Digestive and Liver Disease 2010
Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver
GU Denk, S Maitz, R Wimmer, C Rust, P Invernizzi, S Ferdinandusse, W Kulik, A Fuchsbichler, P Fickert, M Trauner, AF Hofmann, U Beuers
Hepatology 2010
Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53
JD Amaral, RE Castro, S Solá, CJ Steer, CM Rodrigues
Biochemical and Biophysical Research Communications 2010
The correlation between NF-κB inhibition and disease activity by coadministration of silibinin and ursodeoxycholic acid in experimental colitis
H Esmaily, A Vaziri-Bami, AE Miroliaee, M Baeeri, M Abdollahi
Fundamental & Clinical Pharmacology 2010
Primary sclerosing cholangitis: What is the role of ursodeoxycholic acid in therapy for PSC?
RW Chapman
Nature Reviews Gastroenterology & Hepatology 2010
Pharmacotherapy of cholestatic liver diseases
G PAUMGARTNER
Journal of Digestive Diseases 2010
No evidence of direct binding between ursodeoxycholic acid and the p53 DNA-binding domain
JD Amaral, AR Correia, CJ Steer, CM Gomes, CM Rodrigues
Bioscience Reports 2010
Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes
TE Woudenberg-Vrenken, M Buist-Homan, LC de la Rosa, KN Faber, H Moshage
Liver International 2010
Tauroursodeoxycholate counteracts hepatocellular lysis induced by tensioactive bile salts by preventing plasma membrane-micelle transition
CL Basiglio, AD Mottino, MG Roma
Chemico-Biological Interactions 2010
Comprehensive Toxicology
JM Sands, JW Verlander
Comprehensive Toxicology 2010
Antithrombin-III Attenuates Hepatocyte Apoptosis in Bile Duct Ligated Rat: A Striking Cellular Change
CY Huang, SM Sheen-Chen, HT Ho, RP Tang, HL Eng
Surgical Innovation 2010
Clinical Hepatology
H Dancygier
2010
Learning from the pregnane X receptor: how to fight one aggressor with two strategies
C Rust, U Beuers
Liver International 2010
Chronic Liver Failure
P Ginès, PS Kamath, V Arroyo
2010
What is the role of ursodeoxycholic acid in therapy for PSC?
RW Chapman
Nature Reviews Gastroenterology & Hepatology 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Primary biliary cirrhosis
S Hohenester, RP Oude-Elferink, U Beuers
Seminars in Immunopathology 2009
Bile acids: chemistry, physiology, and pathophysiology
MJ Monte, JJ Marin, A Antelo, J Vazquez-Tato
World journal of gastroenterology : WJG 2009
Severe acute cholestatic hepatitis of unknown etiology successfully treated with the Chinese herbal medicine Inchinko-to (TJ-135)
S Ohwada, I Kobayashi, N Harasawa, K Tsuda, Y Inui
World journal of gastroenterology : WJG 2009
Bile acids: regulation of apoptosis by ursodeoxycholic acid
JD Amaral, RJ Viana, RM Ramalho, CJ Steer, CM Rodrigues
Journal of lipid research 2009
Bile acids in treatment of ocular disease
JH Boatright, JM Nickerson, AG Moring, MT Pardue
Journal of Ocular Biology, Diseases, and Informatics 2009
Bile acids as endogenous etiologic agents in gastrointestinal cancer
H Bernstein, C Bernstein, CM Payne, K Dvorak
World journal of gastroenterology : WJG 2009
Bile-acid-induced cell injury and protection
MJ Perez, O Briz
World journal of gastroenterology : WJG 2009
Current concepts of mechanisms in drug-induced hepatotoxicity
S Russmann, GA Kullak-Ublick, I Grattagliano
Current medicinal chemistry 2009
High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis
KD Lindor, KV Kowdley, VA Luketic, ME Harrison, T McCashland, AS Befeler, D Harnois, R Jorgensen, J Petz, J Keach, J Mooney, C Sargeant, J Braaten, T Bernard, D King, E Miceli, J Schmoll, T Hoskin, P Thapa, F Enders
Hepatology 2009
A dose-up of ursodeoxycholic acid decreases transaminases in hepatitis C patients
S Sato, T Miyake, H Tobita, N Oshima, J Ishine, T Hanaoka, Y Amano, Y Kinoshita
World journal of gastroenterology : WJG 2009
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice
LD Beilke, LM Aleksunes, ER Olson, DG Besselsen, CD Klaassen, K Dvorak, NJ Cherrington
Toxicology Letters 2009
Bile acids: developments new and very old
WC Duane
Journal of lipid research 2009
Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells
RJ Viana, AF Nunes, RE Castro, RM Ramalho, J Meyerson, S Fossati, J Ghiso, A Rostagno, CM Rodrigues
Cellular and molecular life sciences : CMLS 2009
Immune-mediated liver diseases: programmed cell death ligands and circulating apoptotic markers
AE Kremer, C Rust, P Eichhorn, U Beuers, S Holdenrieder
Expert Review of Molecular Diagnostics 2009
The role of membrane cholesterol in determining bile acid cytotoxicity and cytoprotection of ursodeoxycholic acid
Y Zhou, R Doyen, LM Lichtenberger
Biochimica et Biophysica Acta (BBA) - Biomembranes 2009
p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis
JD Amaral, RE Castro, CJ Steer, CM Rodrigues
Trends in Molecular Medicine 2009
Minocycline in the Treatment of Patients With Primary Sclerosing Cholangitis: Results of a Pilot Study
MG Silveira, NJ Torok, AA Gossard, JC Keach, RA RN, JL RN, KD Lindor
The American Journal of Gastroenterology 2009
Induction of Regulatory T Cells and Indefinite Survival of Fully Allogeneic Cardiac Grafts by Ursodeoxycholic Acid in Mice
Q Zhang, T Nakaki, D Iwami, M Niimi, N Shirasugi
Transplantation 2009
Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent
W Chamulitrat, J Burhenne, T Rehlen, A Pathil, W Stremmel
Hepatology 2009
Cholestase et maladies cholestatiques
R Poupon
Gastroentérologie Clinique et Biologique 2009
microRNAs identified in highly purified liver-derived mitochondria may play a role in apoptosis
Betsy T. Kren, Phillip Y.-P. Wong, Aaron Sarver, Xiaoxiao Zhang, Yan Zeng, Clifford J. Steer
RNA biology 2009
Lipid and protein oxidation in hepatic homogenates and cell membranes exposed to bile acids
L Fuentes-Broto, E Martínez-Ballarín, J Miana-Mena, C Berzosa, E Piedrafita, I Cebrián, RJ Reiter, JJ García
Free Radical Research 2009
Bile acids: developments new and very old
WC Duane
Journal of lipid research 2009
Bile acids: regulation of apoptosis by ursodeoxycholic acid
JD Amaral, RJ Viana, RM Ramalho, CJ Steer, CM Rodrigues
Journal of lipid research 2009
Intrahepatic cholestasis of pregnancy
V Geenes, C Williamson
World journal of gastroenterology : WJG 2009
Bile acids as endogenous etiologic agents in gastrointestinal cancer
H Bernstein, C Bernstein, CM Payne, K Dvorak
World journal of gastroenterology : WJG 2009
Bile-acid-induced cell injury and protection
MJ Perez, O Briz
World journal of gastroenterology : WJG 2009
A dose-up of ursodeoxycholic acid decreases transaminases in hepatitis C patients
S Sato, T Miyake, H Tobita, N Oshima, J Ishine, T Hanaoka, Y Amano, Y Kinoshita
World journal of gastroenterology : WJG 2009
Severe acute cholestatic hepatitis of unknown etiology successfully treated with the Chinese herbal medicine Inchinko-to (TJ-135)
S Ohwada, I Kobayashi, N Harasawa, K Tsuda, Y Inui
World journal of gastroenterology : WJG 2009
Mitochondrial-Driven Ubiquinone Enhances Extracellular Calcium-Dependent Nitric Oxide Production and Reduces Glycochenodeoxycholic Acid-Induced Cell Death in Hepatocytes
S González-Rubio, AB Hidalgo, G Ferrín, RI Bello, R González, MD Gahete, I Ranchal, BA Rodríguez, P Barrera, P Aguilar-Melero, CI Linares, JP Castaño, VM Victor, MD la Mata, J Muntané
Chemical Research in Toxicology 2009
Role of ursodeoxycholic acid in prevention of hepatotoxicity caused by amoxicillin-clavulanic acid in rats
GA El-Sherbiny, A Taye, IT Abdel-Raheem
ANN HEPATOL 2009
Redox mechanisms in hepatic chronic wound healing and fibrogenesis
E Novo, M Parola
Fibrogenesis & Tissue Repair 2008
Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis
N Anderson, J Borlak
Pharmacological reviews 2008
Cellular and molecular mechanisms of liver injury
H Malhi, GJ Gores
Gastroenterology 2008
Nuclear hormone receptor-dependent regulation of hepatic transporters and their role in the adaptive response in cholestasis
S Stahl, MR Davies, DI Cook, MJ Graham
Xenobiotica 2008
Apoptosis in transgenic mice expressing the P301L mutated form of human tau
RM Ramalho, RJ Viana, RE Castro, CJ Steer, WC Low, CM Rodrigues
Molecular Medicine 2008
Exendin-4, a glucagon-like peptide 1 receptor agonist, protects cholangiocytes from apoptosis
M Marzioni, G Alpini, S Saccomanno, C Candelaresi, J Venter, C Rychlicki, G Fava, H Francis, L Trozzi, A Benedetti
Gut 2008
Ursodeoxycholic acid treatment improves hepatocyte ultrastructure in rat liver fibrosis
N Mas, I Tasci, B Comert, R Ocal, MR Mas
World journal of gastroenterology : WJG 2008
Z-LLY-FMK Can Attenuate Hepatocyte Apoptosis After Bile Duct Ligation in Rat
SM Sheen-Chen, HT Ho, KS Hung, HL Eng
Digestive Diseases and Sciences 2008
Bile acid levels are increased in the liver of patients with steatohepatitis
MM Aranha, H Cortez-Pinto, A Costa, IB da Silva, ME Camilo, MC de Moura, CM Rodrigues
European Journal of Gastroenterology & Hepatology 2008
Effect of Boc-D-Fmk on hepatocyte apoptosis after bile duct ligation in rat and survival rate after endotoxin challenge
SM Sheen-Chen, KS Hung, HL Eng
Journal of Gastroenterology and Hepatology 2008
Free fatty acids sensitize hepatocytes to bile acid-induced apoptosis
T Pusl, N Wild, T Vennegeerts, R Wimmer, B Göke, S Brand, C Rust
Biochemical and Biophysical Research Communications 2008
Ursodeoxycholic acid prevents apoptosis of mouse sensory neurons induced by cisplatin by reducing P53 accumulation
IH Park, MK Kim, SU Kim
Biochemical and Biophysical Research Communications 2008
Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1
T Pusl, T Vennegeerts, R Wimmer, GU Denk, U Beuers, C Rust
Biochemical and Biophysical Research Communications 2008
Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease
RM Ramalho, RJ Viana, WC Low, CJ Steer, CM Rodrigues
Trends in Molecular Medicine 2008
Ursodeoxycholic acid protects concanavalin A-induced mouse liver injury through inhibition of intrahepatic tumor necrosis factor-α and macrophage inflammatory protein-2 production
K Ishizaki, T Iwaki, S Kinoshita, M Koyama, A Fukunari, H Tanaka, M Tsurufuji, K Sakata, Y Maeda, T Imada, K Chiba
European Journal of Pharmacology 2008
Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats
A Çolak, B Kelten, A Sağmanligil, O Akdemir, A Karaoğlan, E Şahan, Ö Çelik, Ş Barut
Journal of Clinical Neuroscience 2008
Pathogenesis of Primary Biliary Cirrhosis
DE Jones
Clinics in Liver Disease 2008
Role of Mitochondria in Drug-Induced Cholestatic Injury
GE Kass, SC Price
Clinics in Liver Disease 2008
Medical Treatment of Cholestatic Liver Disease
G Paumgartner, T Pusl
Clinics in Liver Disease 2008
Tauroursodeoxycholic acid preserves photoreceptor structure and function in the rd10 mouse through post-natal day 30
MJ Phillips, TA Walker, HY Choi, AE Faulkner, MK Kim, SS Sidney, AP Boyd, JM Nickerson, JH Boatright, MT Pardue
Investigative ophthalmology & visual science 2008
Bile acid levels are increased in the liver of patients with steatohepatitis:
MM Aranha, H Cortez-Pinto, A Costa, IB da Silva, ME Camilo, MC de Moura, CM Rodrigues
European Journal of Gastroenterology & Hepatology 2008
Antibacterial and anti-atrophic effects of a highly soluble, acid stable UDCA formula in Helicobacter pylori-induced gastritis
TD Thao, HC Ryu, SH Yoo, DK Rhee
Biochemical Pharmacology 2008
Ursodeoxycholic acid treatment improves hepatocyte ultrastructure in rat liver fi brosis
N Mas, I Tasci, B Comert, R Ocal, MR Mas
World journal of gastroenterology : WJG 2008
Pathogenesis of primary biliary cirrhosis
DE Jones
Gut 2007
Soluble apoptosis molecules in primary biliary cirrhosis: analysis and commitment of the Fas and tumour necrosis factor-related apoptosis-inducing ligand systems in comparison with chronic hepatitis C
N Pelli, A Floreani, F Torre, A Delfino, A Baragiotta, P Contini, M Basso, A Picciotto
Clinical & Experimental Immunology 2007
Interaction between caspase-8 activation and endoplasmic reticulum stress in glycochenodeoxycholic acid-induced apoptotic HepG2 cells
T Iizaka, M Tsuji, H Oyamada, Y Morio, K Oguchi
Toxicology 2007
Bile acid-induced TGR5-dependent c-Jun-N terminal kinase activation leads to enhanced caspase 8 activation in hepatocytes
JI Yang, JH Yoon, SJ Myung, GY Gwak, W Kim, GE Chung, SH Lee, SM Lee, CY Kim, HS Lee
Biochemical and Biophysical Research Communications 2007
Role of Ursodeoxycholic Acid in Prevention of Methotrexate-induced Liver Toxicity
S Uraz, V Tahan, C Aygun, F Eren, G Unluguzel, M Yuksel, O Senturk, E Avsar, G Haklar, C Celikel, S Hulagu, N Tozun
Digestive Diseases and Sciences 2007
Role of mitochondria in cell death induced by Photofrin®–PDT and ursodeoxycholic acid by means of SLIM
I Kinzler, E Haseroth, C Hauser, A Rück
Photochemical & Photobiological Sciences 2007
Study of hepatocytes using RNA interference
S Niimi, M Harashima, M Hyuga, T Yamaguchi
Journal of Organ Dysfunction 2007
Protective effect of ursodeoxycholic acid on liver mitochondrial function in rats with alloxan-induced diabetes: Link with oxidative stress
O Lukivskaya, E Patsenker, VU Buko
Life Sciences 2007
Characterization of overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis according to antimitochondrial antibodies status
L Alric, S Thebault, J Selves, JM Peron, S Mejdoubi, F Fortenfant, JP Vinel
Gastroentérologie Clinique et Biologique 2007
Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis
H Robertson, JA Kirby, WW Yip, DE Jones, AD Burt
Hepatology 2007
Glycoursodeoxycholic Acid and Interleukin-10 Modulate the Reactivity of Rat Cortical Astrocytes to Unconjugated Bilirubin
A Fernandes, AR Vaz, AS Falcão, RF Silva, MA Brito, D Brites
Journal of Neuropathology and Experimental Neurology 2007
Deoxycholic Acid Can Induce Apoptosis in the Human Colon Cancer Cell Line HCT116 in the Absence of Bax
S Yui, R Kanamoto, T Saeki
Nutrition and Cancer 2007
Ursodeoxycholic Acid for the Treatment of Primary Biliary Cirrhosis
K Lindor
New England Journal of Medicine 2007
Function of nuclear steroid receptors in apoptosis: role of ursodeoxycholic acid
JD Amaral, S Solá, CJ Steer, CP Rodrigues
Expert Review of Endocrinology & Metabolism 2007
CD95 activation in the liver: Ion fluxes and oxidative signaling
R Reinehr, D Häussinger
Archives of Biochemistry and Biophysics 2007
Administration of Tauroursodeoxycholic Acid (TUDCA) Reduces Apoptosis Following Myocardial Infarction in Rat
AL Rivard, CJ Steer, BT Kren, CM Rodrigues, RE Castro, RW Bianco, WC Low
The American journal of Chinese medicine 2007
Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes
RE Castro, JD Amaral, S Solá, BT Kren, CJ Steer, CM Rodrigues
AJP Gastrointestinal and Liver Physiology 2007
Bile Acids: Biological Actions and Clinical Relevance
D Keppler, U Leuschner, M Trauner, U Beuers, A Stiehl, G Paumgartner
2007
Transcriptional regulation of metabolism
B Desvergne, L Michalik, W Wahli
Physiological reviews 2006
“Systemic apoptotic response” after thermal burns
G Gravante, D Delogu, G Sconocchia
Apoptosis 2006
17beta-estradiol prevents cytotoxicity from hydrophobic bile acids in HepG2 and WRL-68 cell cultures
M Ricchi, M Bertolotti, C Anzivino, L Carulli, I Canedi, ML Bormioli, R Tiozzo, MA Croce, A Lonardo, N Carulli, P Loria
Journal of Gastroenterology and Hepatology 2006
Rat liver fibrosis regresses better with pegylated interferon alpha2b and ursodeoxycholic acid treatments than spontaneous recovery
II Tasci, MR Mas, SA Vural, B Comert, G Alcigir, M Serdar, N Mas, AT Isik, Y Ates
Liver International 2006
Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts
M Marzioni, H Francis, A Benedetti, Y Ueno, G Fava, J Venter, R Reichenbach, MG Mancino, R Summers, G Alpini, S Glaser
The American Journal of Pathology 2006
Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice
A Ogawa, T Tagawa, H Nishimura, T Yajima, T Abe, T Arai, M Taniguchi, K Takeda, S Akira, Y Nimura, Y Yoshikai
Gut 2006
Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers
C Rust, K Bauchmuller, C Bernt, T Vennegeerts, P Fickert, A Fuchsbichler, U Beuers
Gut 2006
Involvement of endoplasmic reticulum in glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes
S Tsuchiya, M Tsuji, Y Morio, K Oguchi
Toxicology Letters 2006
Eupatilin attenuates bile acid-induced hepatocyte apoptosis
SC Park, JH Yoon, W Kim, GY Gwak, KM Kim, SH Lee, SM Lee, HS Lee
Journal of Gastroenterology 2006
Eupatilin has an antiapoptotic action on hepatocytes, in contrast to apoptotic actions on other cells
T Mine
Journal of Gastroenterology 2006
Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells
RM Ramalho, PM Borralho, RE Castro, S Sola, CJ Steer, CM Rodrigues
Journal of Neurochemistry 2006
Hepatitis C virus core protein inhibits deoxycholic acid-mediated apoptosis despite generating mitochondrial reactive oxygen species
Y Hara, K Hino, M Okuda, T Furutani, I Hidaka, Y Yamaguchi, M Korenaga, K Li, SA Weinman, SM Lemon, K Okita
Journal of Gastroenterology 2006
Maternal cholestasis induces placental oxidative stress and apoptosis. Protective effect of ursodeoxycholic acid
MJ Perez, RI Macias, JJ Marin
Placenta 2006
The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis
C Bernt, T Vennegeerts, U Beuers, C Rust
Biochemical and Biophysical Research Communications 2006
Fooling the Fas ligand in death
CM Rodrigues, CJ Steer
Hepatology 2006
Binding Studies of Bile Acids using the Native Fluorescence of the Tryptophan Residue Of Bax Protein
W Zhang, CJ Steer, KT Douglas, CM Rodrigues
Bioscience Reports 2006
Randomized Placebo-Controlled Trial of Ursodeoxycholic Acid With Vitamin E in Nonalcoholic Steatohepatitis
JF Dufour, CM Oneta, JJ Gonvers, F Bihl, A Cerny, JM Cereda, JF Zala, B Helbling, M Steuerwald, A Zimmermann
Clinical Gastroenterology and Hepatology 2006
Plasma levels of ursodeoxycholic acid in black bears, Ursus americanus: Seasonal changes
S Solá, DL Garshelis, JD Amaral, KV Noyce, PL Coy, CJ Steer, PA Iaizzo, CM Rodrigues
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2006
Ursodeoxycholic acid treatment of vanishing bile duct syndromes
T Pusl, U Beuers
World journal of gastroenterology : WJG 2006
Medical treatment of cholestatic liver diseases: From pathobiology to pharmacological targets
G Paumgartner
World journal of gastroenterology : WJG 2006
Functional Modulation of Nuclear Steroid Receptors by Tauroursodeoxycholic Acid Reduces Amyloid β-Peptide-Induced Apoptosis
S Solá, JD Amaral, PM Borralho, RM Ramalho, RE Castro, MM Aranha, CJ Steer, CM Rodrigues
Molecular Endocrinology 2006
A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid
RE Castro, S Solá, X Ma, RM Ramalho, BT Kren, CJ Steer, CM Rodrigues
Journal of Hepatology 2005
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans
R Ved, S Saha, B Westlund, C Perier, L Burnam, A Sluder, M Hoener, CM Rodrigues, A Alfonso, C Steer, L Liu, S Przedborski, B Wolozin
The Journal of biological chemistry 2005
Cholestatic hepatocellular injury: what do we know and how should we proceed
ME Guicciardi, GJ Gores
Journal of Hepatology 2005
Oncosis represents the main type of cell death in mouse models of cholestasis
P Fickert, M Trauner, A Fuchsbichler, G Zollner, M Wagner, HU Marschall, K Zatloukal, H Denk
Journal of Hepatology 2005
Modulation of apoptosis as a target for liver disease
ST Eichhorst
Expert Opinion on Therapeutic Targets 2005
The effect of ursodeoxycholic acid on glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes
S Utanohara, M Tsuji, S Momma, Y Morio, K Oguchi
Toxicology 2005
Bile Salt–Induced Apoptosis Involves NADPH Oxidase Isoform Activation
R Reinehr, S Becker, V Keitel, A Eberle, S Grether–Beck, D Häussinger
Gastroenterology 2005
Suppressive effect of ursodeoxycholic acid on type IIA phospholipase A2 expression in HepG2 cells
T Ikegami, Y Matsuzaki, S Fukushima, J Shoda, JL Olivier, B Bouscarel, N Tanaka
Hepatology 2005
Synthetic bile acid derivatives induce apoptosis through a c-Jun N-terminal kinase and NF-κB-dependent process in human cervical carcinoma cells
E Im, SH Choi, H Suh, YH Choi, YH Yoo, ND Kim
Cancer Letters 2005
Enteral donor pre-treatment with ursodeoxycholic acid protects the liver against ischaemia-reperfusion injury in rats
G Nowak, UG Nor�n, A Wernerson, HU Marschall, L M�ller, BG Ericzon
Transplant International 2005
Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition
LF Wang, AC Piguet, K Schmidt, T Tordjmann, JF Dufour
Hepatology 2005
Ircinin-1 induces cell cycle arrest and apoptosis in SK-MEL-2 human melanoma cells
HJ Choi, YH Choi, SB Yee, E Im, JH Jung, ND Kim
Molecular Carcinogenesis 2005
Reversible dilated cardiomyopathy associated with amphotericin B treatment
I Moyssakis, TP Vassilakopoulos, NV Sipsas, A Perakis, A Petrou, N Kosmas, GA Pangalis
International Journal of Antimicrobial Agents 2005
Oxidative stress and apoptosis in fetal rat liver induced by maternal cholestasis. Protective effect of ursodeoxycholic acid
MJ Perez, RI Macias, C Duran, MJ Monte, JM Gonzalez-Buitrago, JJ Marin
Journal of Hepatology 2005
Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes
S Solá, JD Amaral, RE Castro, RM Ramalho, PM Borralho, BT Kren, H Tanaka, CJ Steer, CM Rodrigues
Hepatology 2005
Effect of ZVAD-fmk on hepatocyte apoptosis after bile duct ligation in rat
Shyr-Ming Sheen-Chen, Hsin-Tsung Ho, Wei-Jen Chen, Hock-Liew Eng
World journal of gastroenterology : WJG 2005
Primary sclerosing cholangitis: updates in diagnosis and therapy
Piero Portincasa, Michele Vacca, Antonio Moschetta, Michele Petruzzelli, Giuseppe Palasciano, Karel J van Erpecum, Gerard P van Berge-Henegouwen
World journal of gastroenterology : WJG 2005
Primary sclerosing cholangitis: Updates in diagnosis and therapy
P Portincasa
World journal of gastroenterology : WJG 2005
Patients with primary biliary cirrhosis have increased serum total antioxidant capacity measured with the crocin bleaching assay
G Notas
World journal of gastroenterology : WJG 2005
Similar Patterns of Mitochondrial Vulnerability and Rescue Induced by Genetic Modification of α-Synuclein, Parkin, and DJ-1 in Caenorhabditis elegans
R Ved, S Saha, B Westlund, C Perier, L Burnam, A Sluder, M Hoener, CM Rodrigues, A Alfonso, C Steer, L Liu, S Przedborski, B Wolozin
The Journal of biological chemistry 2005
Hypothermic Maintenance of Hepatocyte Spheroids
PH Lai, Q Meng, TD Sielaff, WS Hu
Cell Transplantation 2005
Characteristics of Apoptosis in HCT116 Colon Cancer Cells Induced by Deoxycholic Acid
S Yui, T Saeki, R Kanamoto, K Iwami
Journal of Biochemistry 2005
Phosphatidylinositol 3-kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers
C Rust, K Bauchmuller, P Fickert, A Fuchsbichler, U Beuers
AJP Gastrointestinal and Liver Physiology 2005
Role for Membrane Fluidity in Ethanol-Induced Oxidative Stress of Primary Rat Hepatocytes
O Sergent, M Pereira, C Belhomme, M Chevanne, L Huc, D Lagadic-Gossmann
The Journal of pharmacology and experimental therapeutics 2005
Gastroenterology Yesterday — Today — Tomorrow: A Review and Preview
G Adler, HE Blum, MP Manns, RB Sartor, AL Blum, U Leuschner, J Mössner, J Schölmerich
2005
Bile Acid Biology and its Therapeutic Implications
G Paumgartner, D Keppler, U Leuschner, A Stiehl
2005
Medical Treatment of Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis
C Rust, U Beuers
Clinical Reviews in Allergy & Immunology 2005
Patients with primary biliary cirrhosis have increased serum total antioxidant capacity measured with the crocin bleaching assay.
Notas G, Miliaraki N, Kampa M, Dimoulios F, Matrella E, Hatzidakis A, Castanas E, Kouroumalis E
World Journal of Gastroenterology 2005
The cellular biochemistry of cholesterol and statins: insights into the pathophysiology and therapy of Alzheimer's disease.
Wolozin B, Brown J 3rd, Theisler C, Silberman S
CNS Drug Reviews 2004
Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress
G Serviddio, J Pereda, FV Pallard�, J Carretero, C Borras, J Cutrin, G Vendemiale, G Poli, J Vi�a, J Sastre
Hepatology 2004
The Cellular Biochemistry of Cholesterol and Statins: Insights into the Pathophysiology and Therapy of Alzheimer's Disease
B Wolozin, J Brown, C Theisler, S Silberman
CNS Drug Reviews 2004
Glutathione-S-transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid
A Nobuoka, T Takayama, K Miyanishi, T Sato, K Takanashi, T Hayashi, T Kukitsu, Y Sato, M Takahashi, T Okamoto, T Matsunaga, J Kato, M Oda, T Azuma, Y Niitsu
Gastroenterology 2004
Bile salt-induced apoptosis in human colon cancer cell lines involves the mitochondrial transmembrane potential but not the CD95 (Fas/Apo-1) receptor
FP Wachs, RC Krieg, CM Rodrigues, H Messmann, F Kullmann, R Kn�chel-Clarke, J Sch�lmerich, G Rogler, K Schlottmann
International Journal of Colorectal Disease 2004
Mitochondrially-mediated toxicity of bile acids
CM Palmeira, AP Rolo
Toxicology 2004
Involvement of the Src family kinase yes in bile salt-induced apoptosis
R Reinehr, S Becker, M Wettstein, D Häussinger
Gastroenterology 2004
Reduced oncotic necrosis in fas receptor-deficient C57BL/6J-lpr mice after bile duct ligation
JS Gujral, J Liu, A Farhood, H Jaeschke
Hepatology 2004
Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways
MH Schoemaker, LC de la Rosa, M Buist-Homan, TE Vrenken, R Havinga, K Poelstra, HJ Haisma, PL Jansen, H Moshage
Hepatology 2004
Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes
SI Han, E Studer, S Gupta, Y Fang, L Qiao, W Li, S Grant, PB Hylemon, P Dent
Hepatology 2004
Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95
R Reinehr, D Häussinger
Gastroenterology 2004
Effect of oral ursodeoxycholic acid on bile acids tolerance tests in healthy dogs
L Abraham, J Charles, S Holloway
Australian Veterinary Journal 2004
β-Carotene Prevents Bile Acid-Induced Cytotoxicity in the Rat Hepatocyte: Evidence for an Antioxidant and Anti-Apoptotic Role of β-Carotene In Vitro
E Gumpricht, R Dahl, MW Devereaux, RJ Sokol
Pediatric Research 2004
Metabolic, antioxidant, nutraceutical, probiotic, and herbal therapies relating to the management of hepatobiliary disorders
SA Center
Veterinary Clinics of North America Small Animal Practice 2004
Transporteurs biliaires : de la génétique à la clinique
O Rosmorduc, R Poupon
Gastroentérologie Clinique et Biologique 2004
Toxicity of ethanol and acetaldehyde in hepatocytes treated with ursodeoxycholic or tauroursodeoxycholic acid
K Henzel, C Thorborg, M Hofmann, G Zimmer, U Leuschner
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2004
Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease
J Brown, C Theisler, S Silberman, D Magnuson, N Gottardi-Littell, JM Lee, D Yager, J Crowley, K Sambamurti, MM Rahman, AB Reiss, CB Eckman, B Wolozin
The Journal of biological chemistry 2004
A mechanism for the proapoptotic activity of ursodeoxycholic acid: effects on Bcl-2 conformation
M Castelli, JJ Reiners, D Kessel
Cell Death and Differentiation 2004
Ursodeoxycholic Acid (UDCA) Can Inhibit Deoxycholic Acid (DCA)-induced Apoptosis via Modulation of EGFR/Raf-1/ERK Signaling in Human Colon Cancer Cells
E Im, JD Martinez
The Journal of nutrition 2004
The cellular biochemistry of cholesterol and statins: insights into the pathophysiology and therapy of Alzheimer's disease
Benjamin Wolozin, James Brown 3rd, Catherine Theisler, Simone Silberman
CNS Drug Reviews 2004
Ursodeoxycholate further increases bile-duct cell proliferative response induced by partial bile-duct ligation in rats
M Barone, E Maiorano, R Ladisa, A Pece, P Berloco, M Strazzabosco, ML Caruso, AM Valentini, E Ierardi, AD Leo, A Francavilla
Virchows Archiv 2004
Ursodeoxycholic Acid Ameliorates Experimental Ileitis Counteracting Intestinal Barrier Dysfunction and Oxidative Stress
CF Bernardes-Silva, AO Damião, AM Sipahi, FR Laurindo, K Iriya, FP Lopasso, CA Buchpiguel, ML Lordello, CL Agostinho, AA Laudanna
Digestive Diseases and Sciences 2004
Bile salt-induced apoptosis in human colon cancer cell lines involves the mitochondrial transmembrane potential but not the CD95 (Fas/Apo-1) receptor
FP Wachs, RC Krieg, CM Rodrigues, H Messmann, F Kullmann, R Knchel-Clarke, J Schlmerich, G Rogler, K Schlottmann
International Journal of Colorectal Disease 2004
Effect of Glutamine and Bile Acid on Hepatocyte Apoptosis after Bile Duct Ligation in the Rat
SM Sheen-Chen, KS Hung, HT Ho, WJ Chen, HL Eng
World Journal of Surgery 2004
Primary sclerosing cholangitis
S Cullen, R Chapman
Autoimmunity Reviews 2003
Bilirubin inhibits bile acid induced apoptosis in rat hepatocytes
A Granato, G Gores, MT Vilei, R Tolando, C Ferraresso, M Muraca
Gut 2003
Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats
CM Rodrigues, S Sola, Z Nan, RE Castro, PS Ribeiro, WC Low, CJ Steer
Proceedings of the National Academy of Sciences 2003
Bilirubin, a curse and a boon
JD Ostrow, C Tiribelli
Gut 2003
Bile salt—induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation
R Reinehr, D Graf, D Häussinger
Gastroenterology 2003
Apoptosis and modulation of cell cycle control by synthetic derivatives of ursodeoxycholic acid and chenodeoxycholic acid in human prostate cancer cells
YH Choi, EO Im, H Suh, Y Jin, YH Yoo, ND Kim
Cancer Letters 2003
Circulating soluble cytochrome c in liver disease as a marker of apoptosis
Z Ben-Ari, H Schmilovotz-Weiss, A Belinki, O Pappo, J Sulkes, MG Neuman, E Kaganovsky, B Kfir, R Tur-Kaspa, T Klein
Journal of Internal Medicine 2003
Current aspects of pharmacologic application of bile acids
M Mikov, KK N., JK E.
Medicinski pregled 2003
The effect of ursodeoxycholic acid on the survivin in thapsigargin-induced apoptosis
J Sohn, VI Khaoustov, Q Xie, CC Chung, B Krishnan, B Yoffe
Cancer Letters 2003
Ursodeoxycholic acid inhibits pro-inflammatory repertoires, IL-1β and nitric oxide in rat microglia
SS Joo, HC Kang, TJ Won, DI Lee
Archives of Pharmacal Research 2003
Cytotoxic mechanisms of hydrosulfide anion and cyanide anion in primary rat hepatocyte cultures
RW Thompson, HL Valentine, WM Valentine
Toxicology 2003
Treatment of primary sclerosing cholangitis with low-dose ursodeoxycholic acid: results of a retrospective Italian multicentre survey
L Okolicsanyi, M Groppo, A Floreani, AM Morselli-Labate, AG Rusticali, A Battocchia, M Colombo, G Galatola, G Gasbarrini, M Podda, G Ricci, F Rosina, M Zuin
Digestive and Liver Disease 2003
Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation
MH Schoemaker, WM Gommans, LC de la Rosa, M Homan, P Klok, C Trautwein, H Goor, K Poelstra, HJ Haisma, PL Jansen, H Moshage
Journal of Hepatology 2003
Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratins
P Fickert, M Trauner, A Fuchsbichler, C Stumptner, K Zatloukal, H Denk
Journal of Hepatology 2003
Inhibition of taurolithocholate 3-sulfate-induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and -independent mechanisms
D Graf, R Reinehr, AK Kurz, R Fischer, D Häussinger
Archives of Biochemistry and Biophysics 2003
Current management of primary biliary cirrhosis and primary sclerosing cholangitis
C Levy, KD Lindor
Journal of Hepatology 2003
Combined analysis of the effect of treatment with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis
RE Poupon, KD Lindor, A Parés, O Chazouillères, R Poupon, EJ Heathcote
Journal of Hepatology 2003
Challenges in IBD Research: Updating the Scientific Agendas:
CO Elson, RB Sartor, SR Targan, WJ Sandborn
Inflammatory Bowel Diseases 2003
Mitochondrially mediated synergistic cell killing by bile acids
Anabela P Rolo, Carlos M Palmeira, Kendall B Wallace
Biochimica et Biophysica Acta 2003
Bile Acids Up-regulate Death Receptor 5/TRAIL-receptor 2 Expression via a c-Jun N-terminal Kinase-dependent Pathway Involving Sp1
H Higuchi, A Grambihler, A Canbay, SF Bronk, GJ Gores
The Journal of biological chemistry 2003
cFLIP-L Inhibits p38 MAPK Activation: AN ADDITIONAL ANTI-APOPTOTIC MECHANISM IN BILE ACID-MEDIATED APOPTOSIS
A Grambihler, H Higuchi, SF Bronk, GJ Gores
The Journal of biological chemistry 2003
Ursodeoxycholic Acid Modulates E2F-1 and p53 Expression through a Caspase-independent Mechanism in Transforming Growth Factor β1-induced Apoptosis of Rat Hepatocytes
S Solá, X Ma, RE Castro, BT Kren, CJ Steer, CM Rodrigues
The Journal of biological chemistry 2003
Influence of ursodeoxycholate-enriched diet on liver tumor growth in HBV transgenic mice
M Barone
Hepatology 2003
Klinische Hepatologie
H Dancygier
2003
Role of apoptosis in the remodeling of cholestatic liver injury following release of the mechanical stress
AM Costa, B Tuchweber, T Lamireau, IM Yousef, C Balabaud, J Rosenbaum, A Desmoulière
Virchows Archiv 2003
Tauroursodeoxycholic Acid Prevents Amyloid-β Peptide-Induced Neuronal Death Via a Phosphatidylinositol 3-Kinase-Dependent Signaling Pathway
S Solá, RE Castro, PA Laires, CJ Steer, CM Rodrigues
Molecular Medicine 2003
Mécanismes moléculaires de la formation de la bile et des maladies cholestatiques
R Poupon
Bulletin de l'Académie nationale de médecine 2003
Unique Inhibition of Bile Salt-Induced Apoptosis by Lecithins and Cytoprotective Bile Salts in Immortalized Mouse Cholangiocytes
D Komichi, S Tazuma, T Nishioka, H Hyogo, M Une, K Chayama
Digestive Diseases and Sciences 2003
The management of primary sclerosing cholangitis
RW Chapman
Current Gastroenterology Reports 2003
Multifunctional Role of Fas-Associated Death Domain Protein in Apoptosis
KS Kim
Journal of Biochemistry and molecular biology 2002
Synthetic Bile Acids: Novel Mediators of Apoptosis
ND Kim, EO Im, YH Choi, YH Yoo
Journal of Biochemistry and molecular biology 2002
Cholestasis induces murine hepatocyte apoptosis and DNA synthesis with preservation of the immediate-early gene response
MA Bird, PA Lange, LW Schrum, JW Grisham, RA Rippe, KE Behrns
Surgery 2002
Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways
P Milkiewicz, MG Roma, E Elias, R Coleman
Gut 2002
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease
CD Keene, CM Rodrigues, T Eich, MS Chhabra, CJ Steer, WC Low
Proceedings of the National Academy of Sciences 2002
Interactions of combined bile acids on hepatocyte viability: cytoprotection or synergism
AP Rolo, CM Palmeira, KB Wallace
Toxicology Letters 2002
Endotoxin potentiates hepatocyte apoptosis in cholestasis1 1No competing interests declared
FN Moazzam, JJ Brems, SL Yong, JP Filkins, SG Fisher, DR Holt, RL Gamelli, JW Ding
Journal of the American College of Surgeons 2002
Bile acid-mediated hepatocyte apoptosis and cholestatic liver disease
ME Guicciardi, GJ Gores
Digestive and Liver Disease 2002
Use of ursodeoxycholic acid in patients with liver disease
P Angulo
Current Gastroenterology Reports 2002
Liver Cell Injury and Fibrosis
RJ Sokol
Journal of Pediatric Gastroenterology and Nutrition 2002
Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis
J Tinmouth, M Lee, IR Wanless, FW Tsui, R Inman, EJ Heathcote
Liver International 2002
Neuroprotection by a Bile Acid in an Acute Stroke Model in the Rat
CM Rodrigues, SR Spellman, S Sol??, AW Grande, C Linehan-Stieers, WC Low, CJ Steer
Journal of Cerebral Blood Flow & Metabolism 2002
Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order, and redox status in rat mitochondria
C Rodrigues
Journal of Hepatology 2002
Aging Confers Different Sensitivity to the Neurotoxic Properties of Unconjugated Bilirubin
CM Rodrigues, S Solá, RF Silva, D Brites
Pediatric Research 2002
Induction and Regulation of Hepatocyte Apoptosis by Oxidative Stress
MJ Czaja
Antioxidants & Redox Signaling 2002
Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase–dependent manner
D Graf, AK Kurz, R Fischer, R Reinehr, D Häussinger
Gastroenterology 2002
Nitric Oxide Ameliorates Hydrophobic Bile Acid-induced Apoptosis in Isolated Rat Hepatocytes by Non-mitochondrial Pathways
E Gumpricht, R Dahl, B Yerushalmi, MW Devereaux, RJ Sokol
The Journal of biological chemistry 2002
Ursodeoxycholic acid cytoprotection: Dancing with death receptors and survival pathways
M Guicciardi
Hepatology 2002
Primary biliary cirrhosis with additional features of autoimmune hepatitis: Response to therapy with ursodeoxycholic acid
S Joshi
Hepatology 2002
S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells
E Ansorena
Hepatology 2002
cAMP inhibits bile acid-induced apoptosis by blocking caspase activation and cytochrome c release
CR Webster, P Usechak, MS Anwer
AJP Gastrointestinal and Liver Physiology 2002
Ursodeoxycholic acid diminishes Fas-ligand–induced apoptosis in mouse hepatocytes
F Azzaroli
Hepatology 2002
Prevention of bile acid–induced apoptosis by betaine in rat liver
D Graf
Hepatology 2002
Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons
C Rodrigues
Hepatology 2002
Tauroursodeoxycholic Acid Improves the Survival and Function of Nigral Transplants in a Rat Model of Parkinson's Disease
WM Duan, CM Rodrigures, LR Zhao, CJ Steer, WC Low
Cell Transplantation 2002
Review of Methods to Remove Protein-Bound Substances in Liver Failure
RD Hughes
The International Journal of Artificial Organs 2002
Intrahepatic cholestasis of pregnancy: Changes in maternal-fetal bile acid balance and improvement by ursodeoxycholic acid
D Brites
ANN HEPATOL 2002
Use of ursodeoxycholic acid in liver diseases
D Kumar, RK Tandon
Journal of Gastroenterology and Hepatology 2001
An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity
S Fiorucci, A Mencarelli, B Palazzetti, PD Soldato, A Morelli, LJ Ignarro
Proceedings of the National Academy of Sciences 2001
Bile-salt hydrophobicity is a key factor regulating rat liver plasma-membrane communication: relation to bilayer structure, fluidity and transporter expression and function
Y Asamoto, S Tazuma, H Ochi, K Chayama, H Suzuki
Biochemical Journal 2001
Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis
R Wang, M Salem, IM Yousef, B Tuchweber, P Lam, SJ Childs, CD Helgason, C Ackerley, MJ Phillips, V Ling
Proceedings of the National Academy of Sciences 2001
NF-kappaB is activated in cholestasis and functions to reduce liver injury
H Miyoshi, C Rust, ME Guicciardi, GJ Gores
The American Journal of Pathology 2001
The therapeutic effects of ursodeoxycholic acid as an anti-apoptotic agent
CM Rodrigues, CJ Steer
Expert Opinion on Investigational Drugs 2001
Primary biliary cirrhosis: modalities of injury and death in biliary epithelium
L Marucci, L Ugili, G Macarri, G Feliciangeli, E Bendia, AM Jezequel, F Orlandi, A Benedetti
Digestive and Liver Disease 2001
NF-κB Is Activated in Cholestasis and Functions to Reduce Liver Injury
H Miyoshi, C Rust, ME Guicciardi, GJ Gores
The American Journal of Pathology 2001
Drug therapy of primary biliary diseases: classical and modern strategies
J Schlichting, U Leuschner
Journal of Cellular and Molecular Medicine 2001
Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cells
E Im, YH Choi, KJ Paik, H Suh, Y Jin, KW Kim, YH Yoo, ND Kim
Cancer Letters 2001
A Bile Acid Protects against Motor and Cognitive Deficits and Reduces Striatal Degeneration in the 3-Nitropropionic Acid Model of Huntington's Disease
CD Keene, CM Rodrigues, T Eich, C Linehan-Stieers, A Abt, BT Kren, CJ Steer, WC Low
Experimental Neurology 2001
Ursodeoxycholic acid ‘mechanisms of action and clinical use in hepatobiliary disorders’
KN Lazaridis, GJ Gores, KD Lindor
Journal of Hepatology 2001
Creatine-supplemented diet extends Purkinje cell survival in spinocerebellar ataxia type 1 transgenic mice but does not prevent the ataxic phenotype
WF Kaemmerer, CM Rodrigues, CJ Steer, WC Low
Neuroscience 2001
Clinical and biological relevance of hepatocyte apoptosis in alcoholic hepatitis
M Ziol, M Tepper, M Lohez, G Arcangeli, N Ganne, C Christidis, JC Trinchet, M Beaugrand, JG Guillet, C Guettier
Journal of Hepatology 2001
Agmatine induces apoptosis in rat hepatocyte cultures
G Gardini, C Cabella, C Cravanzola, C Vargiu, S Belliardo, G Testore, SP Solinas, A Toninello, MA Grillo, S Colombatto
Journal of Hepatology 2001
Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid
RF Silva, CM Rodrigues, D Brites
Journal of Hepatology 2001
Amyloid β-Peptide Disrupts Mitochondrial Membrane Lipid and Protein Structure: Protective Role of Tauroursodeoxycholate
CM Rodrigues, S Solá, MA Brito, CD Brondino, D Brites, JJ Moura
Biochemical and Biophysical Research Communications 2001
Apoptosis in Diseases of the Liver
MG Neuman
Critical Reviews in Clinical Laboratory Sciences 2001
Apoptose como mecanismo de lesão nas doenças hepatobiliares
MB PAROLIN, IJ REASON
Arquivos de Gastroenterologia 2001
The Bile Acid Glycochenodeoxycholate Induces TRAIL-Receptor 2/DR5 Expression and Apoptosis
H Higuchi, SF Bronk, Y Takikawa, N Werneburg, R Takimoto, W El-Deiry, GJ Gores
The Journal of biological chemistry 2001
Functional Modulation of the Glucocorticoid Receptor and Suppression of NF-κB-dependent Transcription by Ursodeoxycholic Acid
T Miura, R Ouchida, N Yoshikawa, K Okamoto, Y Makino, T Nakamura, C Morimoto, I Makino, H Tanaka
The Journal of biological chemistry 2001
Modulation of steady-state messenger RNA levels in the regenerating rat liver with bile acid feeding
BT Kren, CM Rodrigues, KD Setchell, CJ Steer
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2001
Deoxycholic Acid (DCA) Causes Ligand-independent Activation of Epidermal Growth Factor Receptor (EGFR) and FAS Receptor in Primary Hepatocytes: Inhibition of EGFR/Mitogen-activated Protein Kinase-Signaling Module Enhances DCA-induced Apoptosis
L Qiao, E Studer, K Leach, R McKinstry, S Gupta, R Decker, R Kukreja, K Valerie, P Nagarkatti, WE Deiry, J Molkentin, R Schmidt-Ullrich, PB Fisher, S Grant, PB Hylemon, P Dent, CH Heldin
Molecular biology of the cell 2001
Geranylgeraniol, an intermediate product in mevalonate pathway, induces apoptotic cell death in human hepatoma cells: death receptor-independent activation of caspase-8 with down-regulation of Bcl-xL expression
Y Takeda, K Nakao, K Nakata, A Kawakami, H Ida, T Ichikawa, M Shigeno, Y Kajiya, K Hamasaki, Y Kato, K Eguchi
Japanese journal of cancer research : Gann 2001
PROTECTIVE ROLE OF TAUROURSODEOXYCHOLATE DURING HARVESTING AND COLD STORAGE OF HUMAN LIVER: A Pilot Study in Transplant Recipients1
L Falasca, G Tisone, G Palmieri, A Anselmo, DD Paolo, L Baiocchi, E Torri, G Orlando, CU Casciani, M Angelico
Transplantation 2001
Chronisch entzündliche Darmerkrankungen
J Stein, A Dignass
2001
Ursodeoxycholic acid and in vitro vasoactivity of hydrophobic bile acids
A Bomzon, P Ljubuncic
Digestive Diseases and Sciences 2001
Geranylgeraniol, an intermediate product in mevalonate pathway, induces apoptotic cell death in human hepatoma cells: death receptor-independent activation of caspase-8 with down-regulation of Bcl-xL expression.
Takeda Y, Nakao K, Nakata K, Kawakami A, Ida H, Ichikawa T, Shigeno M, Kajiya Y, Hamasaki K, Kato Y, Eguchi K
Japanese journal of cancer research : Gann 2001
Pathophysiology of the intrahepatic biliary epithelium
M Strazzabosco, C Spirli, L Okolicsanyi
Journal of Gastroenterology and Hepatology 2000
Genipin, a metabolite derived from the herbal medicine Inchin-ko-to, and suppression of Fas-induced lethal liver apoptosis in mice
M Yamamoto, N Miura, N Ohtake, S Amagaya, A Ishige, H Sasaki, Y Komatsu, K Fukuda, T Ito, K Terasawa
Gastroenterology 2000
Apoptotic cell death does not parallel other indicators of liver damage in chronic hepatitis C patients
Rodrigues, Brites, Serejo, Costa, Ramalho, M. Carneiro de Moura
Journal of Viral Hepatitis 2000
The Japanese multicenter open randomized trial of ursodeoxycholic acid prophylaxis for hepatic veno-occlusive disease after stem cell transplantation
K Ohashi, J Tanabe, R Watanabe, T Tanaka, H Sakamaki, A Maruta, S Okamoto, N Aotsuka, K Saito, M Nishimura, H Oh, M Matsuzaki, S Takahashi, S Yonekura
American Journal of Hematology 2000
Attenuation of Alcohol-Induced Apoptosis of Hepatocytes in Rat Livers by Polyenylphosphatidylcholine (PPC)
LJ Mi, KM Mak, CS Lieber
Alcoholism, clinical and experimental research 2000
Effects of specific bile acids on c-fos messenger RNA levels in human colon carcinoma Caco-2 cells
RD Toro, G Campana, G Murari, S Spampinato
European Journal of Pharmaceutical Sciences 2000
Tauroursodeoxycholic Acid Partially Prevents Apoptosis Induced by 3-Nitropropionic Acid
CM Rodrigues, CL Stieers, CD Keene, X Ma, BT Kren, WC Low, CJ Steer
Journal of Neurochemistry 2000
Mechanisms of liver cell injury
N Kaplowitz
Journal of Hepatology 2000
Apoptosis and liver disease
C Rust, GJ Gores
The American Journal of Medicine 2000
Ursodeoxycholic acid to inhibit the growth of hepatic metastases
BD Keith
Medical Hypotheses 2000
APOPTOSIS IN HEPATIC PATHOPHYSIOLOGY
T Patel
Clinics in Liver Disease 2000
CELL DEATH AT THE MILLENNIUM
N Kaplowitz
Clinics in Liver Disease 2000
Mitochondrial control of cell death
G Kroemer, JC Reed
Nature Medicine 2000
Chronic cholestatic diseases
R Poupon, O Chazouillères, RE Poupon
Journal of Hepatology 2000
Ursodeoxycholic acid for primary biliary cirrhosis: lessons from the pastissues for the future
RE Poupon
Journal of Hepatology 2000
Mitochondrial membrane perturbations in cholestasis
CM Rodrigues, CJ Steer
Journal of Hepatology 2000
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
CJ Sinal, M Tohkin, M Miyata, JM Ward, G Lambert, FJ Gonzalez
Cell 2000
THE CELL AND MOLECULAR BIOLOGY OF HEPATIC FIBROGENESIS
DC Rockey
Clinics in Liver Disease 2000
The NAD+ precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate
CL Crowley, CM Payne, H Bernstein, C Bernstein, D Roe
Cell Death and Differentiation 2000
Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas
T Sodeman, SF Bronk, PJ Roberts, H Miyoshi, GJ Gores
AJP Gastrointestinal and Liver Physiology 2000
Soluble Fas is increased in serum of patients with primary biliary cirrhosis, but is not a useful marker for disease activity
J Gozlan, I Nion, O Chazouilleres, Y Chretien, R Poupon
The American Journal of Gastroenterology 2000
Bilirubin and Amyloid-β Peptide Induce Cytochrome c Release Through Mitochondrial Membrane Permeabilization
CM Rodrigues, S Solá, R Silva, D Brites
Molecular Medicine 2000
Immunology and Liver
MP Manns, G Paumgartner, U Leuschner
2000
Apoptosis and Its Modulation by Drugs
RG Cameron, G Feuer
2000
Attenuation of Alcohol-Induced Apoptosis of Hepatocytes in Rat Livers by Polyenylphosphatidylcholine (PPC):
LJ Mi, KM Mak, CS Lieber
Alcoholism, clinical and experimental research 2000
Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity
B Gonzalez, C Fisher, B G Rosser
Molecular and Cellular Biochemistry 2000
Ursodeoxycholic acid suppresses extent of lipid peroxidation in diseased liver in experimental cholestatic liver disease
P Ljubuncic, Z Tanne, A Bomzon
Digestive Diseases and Sciences 2000
The significance of apoptosis in the liver
A Benedetti, L Marucci
Liver International 1999
Cellular and molecular biology of the liver
SJ Karpen, JM Crawford
Current Opinion in Gastroenterology 1999
Cholestatic syndromes
M Trauner, JL Boyer
Current Opinion in Gastroenterology 1999
Bile acids and hepatocyte apoptosis: Living/leaving life in the Fas lane
CM Rodrigues, CJ Steer
Gastroenterology 1999
Review article: mechanisms of action and therapeutic applications of ursodeoxycholic acid in chronic liver diseases
Trauner, Graziadei
Alimentary Pharmacology & Therapeutics 1999
Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas
H Miyoshi, C Rust, PJ Roberts, LJ Burgart, GJ Gores
Gastroenterology 1999
Cholestatic syndromes:
M Trauner, JL Boyer
Current Opinion in Gastroenterology 1999
Biliary bile acids in primary biliary cirrhosis: effect of ursodeoxycholic acid
B Combes, RL Carithers, WC Maddrey, S Munoz, G Garcia-Tsao, GF Bonner, JL Boyer, VA Luketic, ML Shiffman, MG Peters, H White, RK Zetterman, R Risser, SS Rossi, AF Hofmann
Hepatology 1999
Ursodeoxycholic acid as adjunctive therapy for problematic type 1 autoimmune hepatitis: A randomized placebo-controlled treatment trial
AJ Czaja, HA Carpenter, KD Lindor
Hepatology 1999
Molecular Pathogenesis of Cholestasis
FH Epstein, M Trauner, PJ Meier, JL Boyer
New England Journal of Medicine 1998
Principles of Medical Biology
JO Jørgensen
Principles of Medical Biology 1998

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