The hydrophilic bile salt ursodeoxycholic acid (UDCA) protects against the membrane-damaging effects associated with hydrophobic bile acids. This study was undertaken to (a) determine if UDCA inhibits apoptosis from deoxycholic acid (DCA), as well as from ethanol, TGF-beta1, Fas ligand, and okadaic acid; and to (b) determine whether mitochondrial membrane perturbation is modulated by UDCA. DCA induced significant hepatocyte apoptosis in vivo and in isolated hepatocytes determined by terminal transferase-mediated dUTP-digoxigenin nick end-labeling assay and nuclear staining, respectively (P < 0.001). Apoptosis in isolated rat hepatocytes increased 12-fold after incubation with 0.5% ethanol (P < 0.001). HuH-7 cells exhibited increased apoptosis with 1 nM TGF-beta1 (P < 0. 001) or DCA at >/= 100 microM (P < 0.001), as did Hep G2 cells after incubation with anti-Fas antibody (P < 0.001). Finally, incubation with okadaic acid induced significant apoptosis in HuH-7, Saos-2, Cos-7, and HeLa cells. Coadministration of UDCA with each of the apoptosis-inducing agents was associated with a 50-100% inhibition of apoptotic changes (P < 0.001) in all the cell types. Also, UDCA reduced the mitochondrial membrane permeability transition (MPT) in isolated mitochondria associated with both DCA and phenylarsine oxide by > 40 and 50%, respectively (P < 0.001). FACS(R) analysis revealed that the apoptosis-inducing agents decreased the mitochondrial transmembrane potential and increased reactive oxygen species production (P < 0.05). Coadministration of UDCA was associated with significant prevention of mitochondrial membrane alterations in all cell types. The results suggest that UDCA plays a central role in modulating the apoptotic threshold in both hepatocytes and nonliver cells, and inhibition of MPT is at least one pathway by which UDCA protects against apoptosis.
C M Rodrigues, G Fan, X Ma, B T Kren, C J Steer
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Molecular and cellular biology | 2014 |
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M Basar, I Bozkurt, O Guzeloglu-Kayisli, B Sozen, I Tekmen, F Schatz, A Arici, CJ Lockwood, UA Kayisli |
Fertility and Sterility | 2014 |
Prospective Randomized Trial of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid for Prevention of Radiation-Induced Liver Toxicity
M Seidensticker, R Seidensticker, R Damm, K Mohnike, M Pech, B Sangro, P Hass, P Wust, S Kropf, G Gademann, J Ricke, V Wong |
PloS one | 2014 |
The therapeutic potential of chemical chaperones in protein folding diseases
L Cortez, V Sim |
Prion | 2014 |
Hepatolithiasis: analysis of Japanese nationwide surveys over a period of 40 years
Y Suzuki, T Mori, M Yokoyama, T Nakazato, N Abe, Y Nakanuma, H Tsubouchi, M Sugiyama |
Journal of Hepato-Biliary-Pancreatic Sciences | 2014 |
Synbiotics: the impact of potential prebiotics inulin, lactulose and lactobionic acid on the survival and growth of lactobacilli probiotics
OO Adebola, O Corcoran, WA Morgan |
Journal of Functional Foods | 2014 |
Three Measurable and Modifiable Enteric Microbial Biotransformations Relevant to Cancer Prevention and Treatment
GA Plotnikoff |
Global Advances in Health and Medicine | 2014 |
Silencing of the hTERT Gene by shRNA Inhibits Colon Cancer SW480 Cell Growth In Vitro and In Vivo
AQ Liu, LY Ge, XL Lu, XL Luo, YL Cai, XQ Ye, FF Geng, A Ahmad |
PloS one | 2014 |
Ursodeoxycholic Acid Ameliorates Apoptotic Cascade in the Rotenone Model of Parkinson’s Disease: Modulation of Mitochondrial Perturbations
NF Abdelkader, MM Safar, HA Salem |
Molecular Neurobiology | 2014 |
The therapeutic potential of chemical chaperones in protein folding diseases.
Cortez L, Sim V |
Prion | 2014 |
Comprehensive Physiology
LJ Dixon, M Barnes, H Tang, MT Pritchard, LE Nagy |
Comprehensive Physiology | 2013 |
Comprehensive Physiology
LJ Dixon, M Barnes, H Tang, MT Pritchard, LE Nagy |
Comprehensive Physiology | 2013 |
Comprehensive Physiology
LJ Dixon, M Barnes, H Tang, MT Pritchard, LE Nagy |
Comprehensive Physiology | 2013 |
Comprehensive Physiology
LJ Dixon, M Barnes, H Tang, MT Pritchard, LE Nagy |
Comprehensive Physiology | 2013 |
Comprehensive Physiology
LJ Dixon, M Barnes, H Tang, MT Pritchard, LE Nagy |
Comprehensive Physiology | 2013 |
Comprehensive Physiology
LJ Dixon, M Barnes, H Tang, MT Pritchard, LE Nagy |
Comprehensive Physiology | 2013 |
Interventions for treating cholestasis in pregnancy
V Gurung, M Stokes, P Middleton, SJ Milan, W Hague, JG Thornton |
Cochrane Database of Systematic Reviews | 2013 |
An updated review on drug-induced cholestasis: Mechanisms and investigation of physicochemical properties and pharmacokinetic parameters
K Yang, K Köck, A Sedykh, A Tropsha, KL Brouwer |
Journal of Pharmaceutical Sciences | 2013 |
Protective effects of prebiotics inulin and lactulose from cytotoxicity and genotoxicity in human colon adenocarcinoma cells
O Adebola, O Corcoran, WA Morgan |
Food Research International | 2013 |
Non-alcoholic steatohepatitis in morbidly obese patients
A Tran, P Gual |
Clinics and Research in Hepatology and Gastroenterology | 2013 |
Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations
J Mello-Vieira, T Sousa, A Coutinho, A Fedorov, SD Lucas, R Moreira, RE Castro, CM Rodrigues, M Prieto, F Fernandes |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 2013 |
Role of glucuronidation for hepatic detoxification and urinary elimination of toxic bile acids during biliary obstruction
M Perreault, A Białek, J Trottier, M Verreault, P Caron, P Milkiewicz, O Barbier |
PloS one | 2013 |
Regulation of basal lateral membrane mobility and permeability to divalent cations by membrane associated-protein kinase C
C Zhang, Y Zheng, L Chen, M Chen, S Liang, M Lin, D Luo |
PloS one | 2013 |
Alcohol Consumption Decreases Rat Hepatic Creatine Biosynthesis Via Altered Guanidinoacetate Methyltransferase Activity
KK Kharbanda, SL Todero, JC Moats, RM Harris, NA Osna, PG Thomes, DJ Tuma |
Alcoholism Clinical and Experimental Research | 2013 |
Regulation of Basal Lateral Membrane Mobility and Permeability to Divalent Cations by Membrane Associated-Protein Kinase C
C Zhang, Y Zheng, L Chen, M Chen, S Liang, M Lin, D Luo, D Holowka |
PloS one | 2013 |
Role of Glucuronidation for Hepatic Detoxification and Urinary Elimination of Toxic Bile Acids during Biliary Obstruction
M Perreault, A Białek, J Trottier, M Verreault, P Caron, P Milkiewicz, O Barbier, MA Avila |
PloS one | 2013 |
Higher Fecal Bile Acid Hydrophobicity Is Associated with Exacerbation of Dextran Sodium Sulfate Colitis in Mice
LK Stenman, R Holma, R Forsgård, H Gylling, R Korpela |
The Journal of nutrition | 2013 |
Prevention of acute kidney injury by tauroursodeoxycholic acid in rat and cell culture models
S Gupta, S Li, MJ Abedin, K Noppakun, L Wang, T Kaur, B Najafian, CM Rodrigues, CJ Steer |
PloS one | 2012 |
The Immunophysiology and Apoptosis of Biliary Epithelial Cells: Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis
K Kawata, Y Kobayashi, ME Gershwin, CL Bowlus |
Clinical Reviews in Allergy & Immunology | 2012 |
Novel insight into mechanisms of cholestatic liver injury
BL Woolbright, H Jaeschke |
World journal of gastroenterology : WJG | 2012 |
Molecular Mechanisms of Ursodeoxycholic Acid Toxicity & Side Effects: Ursodeoxycholic Acid Freezes Regeneration & Induces Hibernation Mode
MA Kotb |
International journal of molecular sciences | 2012 |
Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation
R Cursio, J Gugenheim |
Journal of Transplantation | 2012 |
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz |
Protein Engineering for Therapeutics Part B | 2012 |
Damage to mtDNA in liver injury of patients with extrahepatic cholestasis: The protective effects of mitochondrial transcription factor A
SC Xu, YB Chen, H Lin, HF Pi, NX Zhang, CC Zhao, L Shuai, M Zhong, ZP Yu, Z Zhou, P Bie |
Free radical biology & medicine | 2012 |
The Liver and Parenteral Nutrition
KM Khan, NC Kumar, RW Gruessner |
Zakim and Boyer s Hepatology | 2012 |
Ursodeoxycholic Acid Protects Colon Cancer HCT116 Cells From Deoxycholic Acid-Induced Apoptosis by Inhibiting Apoptosome Formation
T Saeki, S Yui, T Hirai, T Fujii, S Okada, R Kanamoto |
Nutrition and Cancer | 2012 |
Tauroursodeoxycholic Acid Prevents MPTP-Induced Dopaminergic Cell Death in a Mouse Model of Parkinson’s Disease
M Castro-Caldas, AN Carvalho, E Rodrigues, CJ Henderson, CR Wolf, CM Rodrigues, MJ Gama |
Molecular Neurobiology | 2012 |
Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice
AC Lo, Z Callaerts-Vegh, AF Nunes, CM Rodrigues, R D'Hooge |
Neurobiology of Disease | 2012 |
Bile acids: From digestion to cancers
M Baptissart, A Vega, S Maqdasy, F Caira, S Baron, JM Lobaccaro, DH Volle |
Biochimie | 2012 |
Possible mechanisms underlying the biphasic regulatory effects of arachidonic acid on Ca2+ signaling in HEK293 cells
L Chen, Q Meng, X Yu, C Li, C Zhang, C Cui, D Luo |
Cellular Signalling | 2012 |
Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice
RM Ramalho, AF Nunes, RB Dias, JD Amaral, AC Lo, R D'Hooge, AM Sebastião, CM Rodrigues |
Neurobiology of Aging | 2012 |
miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
RE Castro, DM Ferreira, MB Afonso, PM Borralho, MV Machado, H Cortez-Pinto, CM Rodrigues |
Journal of Hepatology | 2012 |
Treatment of NASH with ursodeoxycholic acid: Pro
V Ratziu |
Clinics and Research in Hepatology and Gastroenterology | 2012 |
Primary biliary cirrhosis and bile acids
C Corpechot |
Clinics and Research in Hepatology and Gastroenterology | 2012 |
Treatment of NASH with ursodeoxycholic acid: Cons
F Liechti, JF Dufour |
Clinics and Research in Hepatology and Gastroenterology | 2012 |
The Nicotinamide Adenine Dinucleotide Phosphate Oxidase Homologues NOX1 and NOX2/gp91phox Mediate Hepatic Fibrosis in Mice
YH Paik, K Iwaisako, E Seki, S Inokuchi, B Schnabl, CH Osterreicher, T Kisseleva, DA Brenner |
Hepatology | 2011 |
Tauroursodeoxycholic Acid (TUDCA) Protects Photoreceptors from Cell Death after Experimental Retinal Detachment
D Mantopoulos, Y Murakami, J Comander, A Thanos, M Roh, JW Miller, DG Vavvas |
PloS one | 2011 |
The role of the innate immune recognition system in the pathogenesis of primary biliary cirrhosis: a conceptual view
PA Berg |
Liver International | 2011 |
Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications
MG Roma, FD Toledo, AC Boaglio, CL Basiglio, FA Crocenzi, EJ Sánchez Pozzi |
Clinical Science | 2011 |
Comparison of different bile acid-phospholipid conjugates in acute hepatitis
A Pathil, A Warth, W Chamulitrat, W Stremmel |
European Journal of Clinical Investigation | 2011 |
A role for protein kinase C in the regulation of membrane fluidity and Ca2+ flux at the endoplasmic reticulum and plasma membranes of HEK293 and Jurkat cells
L Chen, Q Meng, X Jing, P Xu, D Luo |
Cellular Signalling | 2011 |
Nitric oxide mimics transcriptional and post-translational regulation during α-Tocopherol cytoprotection against glycochenodeoxycholate-induced cell death in hepatocytes
R González, A Cruz, G Ferrín, P López-Cillero, R Fernández-Rodríguez, J Briceño, MA Gómez, S Rufián, MD la Mata, A Martínez-Ruiz, JJ Marin, J Muntané |
Journal of Hepatology | 2011 |
Ursodeoxycholic acid treatment of hepatic steatosis: a 13C NMR metabolic study
PM Nunes, JG Jones, AP Rolo, CM Palmeira, RA Carvalho |
NMR in Biomedicine | 2011 |
A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis
V Ratziu, V Ledinghen, F Oberti, P Mathurin, C Wartelle-Bladou, C Renou, P Sogni, M Maynard, D Larrey, L Serfaty, D Bonnefont-Rousselot, JP Bastard, M Rivière, J Spénard |
Journal of Hepatology | 2011 |
Meta-analysis: ursodeoxycholic acid for primary sclerosing cholangitis
CK Triantos, NM Koukias, VN Nikolopoulou, AK Burroughs |
Alimentary Pharmacology & Therapeutics | 2011 |
The protective effects of ursodeoxycholic acid on isoniazid plus rifampicin induced liver injury in mice
X Chen, J Xu, C Zhang, T Yu, H Wang, M Zhao, ZH Duan, Y Zhang, JM Xu, DX Xu |
European Journal of Pharmacology | 2011 |
Alternative therapeutic advantages of catfish bile on atopic dermatitis: protection of T cell-mediated skin disease via antioxidant activities
DI Lee, YJ Huh, KW Hwang, YW Choi, JS Choi, SY Han, YS Gyoung, SS Joo |
Journal of Pharmacy and Pharmacology | 2011 |
Mechanisms of Liver Injury
H Malhi, GJ Gores |
Schiff s Diseases of the Liver Schiff/Schiff s Diseases of the Liver | 2011 |
cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase
A Johnston, K Ponzetti, MS Anwer, CR Webster |
AJP Gastrointestinal and Liver Physiology | 2011 |
Bile Acids Induce Inflammatory Genes in Hepatocytes
K Allen, H Jaeschke, BL Copple |
The American Journal of Pathology | 2011 |
Neuronal loss in the rostral ventromedial medulla in a rat model of neuropathic pain
ML Leong, M Gu, R Speltz-Paiz, EI Stahura, N Mottey, CJ Steer, M Wessendorf |
Journal of Neuroscience | 2011 |
Tauroursodeoxycholic Acid Enhances the Pre-Implantation Embryo Development by Reducing Apoptosis in Pigs : TUDCA Enhances Porcine Embryo Development
JS Kim, BS Song, KS Lee, DH Kim, SU Kim, YK Choo, KT Chang, DB Koo |
Reproduction in Domestic Animals | 2011 |
Fetal and Neonatal Physiology
LH Johnson, VK Bhutani |
Fetal and Neonatal Physiology | 2011 |
Schiff's Diseases of the Liver: Schiff/Schiff's Diseases of the Liver
H Malhi, GJ Gores |
Schiff's Diseases of the Liver: Schiff/Schiff's Diseases of the Liver | 2011 |
High-dose ursodeoxycholic acid increases risk of adverse outcomes in patients with early stage primary sclerosing cholangitis
MH Imam, E Sinakos, AA Gossard, KV Kowdley, VA Luketic, ME Harrison, T McCashland, AS Befeler, D Harnois, R Jorgensen, J Petz, J Keach, AC DeCook, F Enders, KD Lindor |
Alimentary Pharmacology and Therapeutics | 2011 |
Isolation of Primary Human Hepatocytes from Normal and Diseased Liver Tissue: A One Hundred Liver Experience
RH Bhogal, J Hodson, DC Bartlett, CJ Weston, SM Curbishley, E Haughton, KT Williams, GM Reynolds, PN Newsome, DH Adams, SC Afford, N Wong |
PloS one | 2011 |
Therapeutic effects of the novel bile acid-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) in acute liver injury
Anita Pathil, Arne Warth, Walee Chamulitrat, Wolfgang Stremmel |
Journal of Hepatology | 2010 |
Hepatocyte death: a clear and present danger
H Malhi, ME Guicciardi, GJ Gores |
Physiological reviews | 2010 |
Changes in Hepatic Gene Expression upon Oral Administration of Taurine-Conjugated Ursodeoxycholic Acid in ob/ob Mice
JS Yang, JT Kim, J Jeon, HS Park, GH Kang, KS Park, HK Lee, S Kim, YM Cho, TI Sorensen |
PloS one | 2010 |
A pilot trial of high-dose ursodeoxycholic acid in nonalcoholic steatohepatitis
LA Adams, P Angulo, J Petz, J Keach, KD Lindor |
Hepatology International | 2010 |
Novel treatment modalities for nonalcoholic steatohepatitis
SK Satapathy, AJ Sanyal |
Trends in Endocrinology & Metabolism | 2010 |
Bile acid changes after high-dose ursodeoxycholic acid treatment in primary sclerosing cholangitis: Relation to disease progression
E Sinakos, HU Marschall, KV Kowdley, A Befeler, J Keach, K Lindor |
Hepatology | 2010 |
Bile salts and cholestasis
LM de Wenniger, U Beuers |
Digestive and Liver Disease | 2010 |
Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver
GU Denk, S Maitz, R Wimmer, C Rust, P Invernizzi, S Ferdinandusse, W Kulik, A Fuchsbichler, P Fickert, M Trauner, AF Hofmann, U Beuers |
Hepatology | 2010 |
Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53
JD Amaral, RE Castro, S Solá, CJ Steer, CM Rodrigues |
Biochemical and Biophysical Research Communications | 2010 |
The correlation between NF-κB inhibition and disease activity by coadministration of silibinin and ursodeoxycholic acid in experimental colitis
H Esmaily, A Vaziri-Bami, AE Miroliaee, M Baeeri, M Abdollahi |
Fundamental & Clinical Pharmacology | 2010 |
Primary sclerosing cholangitis: What is the role of ursodeoxycholic acid in therapy for PSC?
RW Chapman |
Nature Reviews Gastroenterology & Hepatology | 2010 |
Pharmacotherapy of cholestatic liver diseases
G PAUMGARTNER |
Journal of Digestive Diseases | 2010 |
No evidence of direct binding between ursodeoxycholic acid and the p53 DNA-binding domain
JD Amaral, AR Correia, CJ Steer, CM Gomes, CM Rodrigues |
Bioscience Reports | 2010 |
Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes
TE Woudenberg-Vrenken, M Buist-Homan, LC de la Rosa, KN Faber, H Moshage |
Liver International | 2010 |
Tauroursodeoxycholate counteracts hepatocellular lysis induced by tensioactive bile salts by preventing plasma membrane-micelle transition
CL Basiglio, AD Mottino, MG Roma |
Chemico-Biological Interactions | 2010 |
Comprehensive Toxicology
JM Sands, JW Verlander |
Comprehensive Toxicology | 2010 |
Antithrombin-III Attenuates Hepatocyte Apoptosis in Bile Duct Ligated Rat: A Striking Cellular Change
CY Huang, SM Sheen-Chen, HT Ho, RP Tang, HL Eng |
Surgical Innovation | 2010 |
Clinical Hepatology
H Dancygier |
2010 | |
Learning from the pregnane X receptor: how to fight one aggressor with two strategies
C Rust, U Beuers |
Liver International | 2010 |
Chronic Liver Failure
P Ginès, PS Kamath, V Arroyo |
2010 | |
What is the role of ursodeoxycholic acid in therapy for PSC?
RW Chapman |
Nature Reviews Gastroenterology & Hepatology | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Primary biliary cirrhosis
S Hohenester, RP Oude-Elferink, U Beuers |
Seminars in Immunopathology | 2009 |
Bile acids: chemistry, physiology, and pathophysiology
MJ Monte, JJ Marin, A Antelo, J Vazquez-Tato |
World journal of gastroenterology : WJG | 2009 |
Severe acute cholestatic hepatitis of unknown etiology successfully treated with the Chinese herbal medicine Inchinko-to (TJ-135)
S Ohwada, I Kobayashi, N Harasawa, K Tsuda, Y Inui |
World journal of gastroenterology : WJG | 2009 |
Bile acids: regulation of apoptosis by ursodeoxycholic acid
JD Amaral, RJ Viana, RM Ramalho, CJ Steer, CM Rodrigues |
Journal of lipid research | 2009 |
Bile acids in treatment of ocular disease
JH Boatright, JM Nickerson, AG Moring, MT Pardue |
Journal of Ocular Biology, Diseases, and Informatics | 2009 |
Bile acids as endogenous etiologic agents in gastrointestinal cancer
H Bernstein, C Bernstein, CM Payne, K Dvorak |
World journal of gastroenterology : WJG | 2009 |
Bile-acid-induced cell injury and protection
MJ Perez, O Briz |
World journal of gastroenterology : WJG | 2009 |
Current concepts of mechanisms in drug-induced hepatotoxicity
S Russmann, GA Kullak-Ublick, I Grattagliano |
Current medicinal chemistry | 2009 |
High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis
KD Lindor, KV Kowdley, VA Luketic, ME Harrison, T McCashland, AS Befeler, D Harnois, R Jorgensen, J Petz, J Keach, J Mooney, C Sargeant, J Braaten, T Bernard, D King, E Miceli, J Schmoll, T Hoskin, P Thapa, F Enders |
Hepatology | 2009 |
A dose-up of ursodeoxycholic acid decreases transaminases in hepatitis C patients
S Sato, T Miyake, H Tobita, N Oshima, J Ishine, T Hanaoka, Y Amano, Y Kinoshita |
World journal of gastroenterology : WJG | 2009 |
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice
LD Beilke, LM Aleksunes, ER Olson, DG Besselsen, CD Klaassen, K Dvorak, NJ Cherrington |
Toxicology Letters | 2009 |
Bile acids: developments new and very old
WC Duane |
Journal of lipid research | 2009 |
Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells
RJ Viana, AF Nunes, RE Castro, RM Ramalho, J Meyerson, S Fossati, J Ghiso, A Rostagno, CM Rodrigues |
Cellular and molecular life sciences : CMLS | 2009 |
Immune-mediated liver diseases: programmed cell death ligands and circulating apoptotic markers
AE Kremer, C Rust, P Eichhorn, U Beuers, S Holdenrieder |
Expert Review of Molecular Diagnostics | 2009 |
The role of membrane cholesterol in determining bile acid cytotoxicity and cytoprotection of ursodeoxycholic acid
Y Zhou, R Doyen, LM Lichtenberger |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 2009 |
p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis
JD Amaral, RE Castro, CJ Steer, CM Rodrigues |
Trends in Molecular Medicine | 2009 |
Minocycline in the Treatment of Patients With Primary Sclerosing Cholangitis: Results of a Pilot Study
MG Silveira, NJ Torok, AA Gossard, JC Keach, RA RN, JL RN, KD Lindor |
The American Journal of Gastroenterology | 2009 |
Induction of Regulatory T Cells and Indefinite Survival of Fully Allogeneic Cardiac Grafts by Ursodeoxycholic Acid in Mice
Q Zhang, T Nakaki, D Iwami, M Niimi, N Shirasugi |
Transplantation | 2009 |
Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent
W Chamulitrat, J Burhenne, T Rehlen, A Pathil, W Stremmel |
Hepatology | 2009 |
Cholestase et maladies cholestatiques
R Poupon |
Gastroentérologie Clinique et Biologique | 2009 |
microRNAs identified in highly purified liver-derived mitochondria may play a role in apoptosis
Betsy T. Kren, Phillip Y.-P. Wong, Aaron Sarver, Xiaoxiao Zhang, Yan Zeng, Clifford J. Steer |
RNA biology | 2009 |
Lipid and protein oxidation in hepatic homogenates and cell membranes exposed to bile acids
L Fuentes-Broto, E Martínez-Ballarín, J Miana-Mena, C Berzosa, E Piedrafita, I Cebrián, RJ Reiter, JJ García |
Free Radical Research | 2009 |
Bile acids: developments new and very old
WC Duane |
Journal of lipid research | 2009 |
Bile acids: regulation of apoptosis by ursodeoxycholic acid
JD Amaral, RJ Viana, RM Ramalho, CJ Steer, CM Rodrigues |
Journal of lipid research | 2009 |
Intrahepatic cholestasis of pregnancy
V Geenes, C Williamson |
World journal of gastroenterology : WJG | 2009 |
Bile acids as endogenous etiologic agents in gastrointestinal cancer
H Bernstein, C Bernstein, CM Payne, K Dvorak |
World journal of gastroenterology : WJG | 2009 |
Bile-acid-induced cell injury and protection
MJ Perez, O Briz |
World journal of gastroenterology : WJG | 2009 |
A dose-up of ursodeoxycholic acid decreases transaminases in hepatitis C patients
S Sato, T Miyake, H Tobita, N Oshima, J Ishine, T Hanaoka, Y Amano, Y Kinoshita |
World journal of gastroenterology : WJG | 2009 |
Severe acute cholestatic hepatitis of unknown etiology successfully treated with the Chinese herbal medicine Inchinko-to (TJ-135)
S Ohwada, I Kobayashi, N Harasawa, K Tsuda, Y Inui |
World journal of gastroenterology : WJG | 2009 |
Mitochondrial-Driven Ubiquinone Enhances Extracellular Calcium-Dependent Nitric Oxide Production and Reduces Glycochenodeoxycholic Acid-Induced Cell Death in Hepatocytes
S González-Rubio, AB Hidalgo, G Ferrín, RI Bello, R González, MD Gahete, I Ranchal, BA Rodríguez, P Barrera, P Aguilar-Melero, CI Linares, JP Castaño, VM Victor, MD la Mata, J Muntané |
Chemical Research in Toxicology | 2009 |
Role of ursodeoxycholic acid in prevention of hepatotoxicity caused by amoxicillin-clavulanic acid in rats
GA El-Sherbiny, A Taye, IT Abdel-Raheem |
ANN HEPATOL | 2009 |
Redox mechanisms in hepatic chronic wound healing and fibrogenesis
E Novo, M Parola |
Fibrogenesis & Tissue Repair | 2008 |
Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis
N Anderson, J Borlak |
Pharmacological reviews | 2008 |
Cellular and molecular mechanisms of liver injury
H Malhi, GJ Gores |
Gastroenterology | 2008 |
Nuclear hormone receptor-dependent regulation of hepatic transporters and their role in the adaptive response in cholestasis
S Stahl, MR Davies, DI Cook, MJ Graham |
Xenobiotica | 2008 |
Apoptosis in transgenic mice expressing the P301L mutated form of human tau
RM Ramalho, RJ Viana, RE Castro, CJ Steer, WC Low, CM Rodrigues |
Molecular Medicine | 2008 |
Exendin-4, a glucagon-like peptide 1 receptor agonist, protects cholangiocytes from apoptosis
M Marzioni, G Alpini, S Saccomanno, C Candelaresi, J Venter, C Rychlicki, G Fava, H Francis, L Trozzi, A Benedetti |
Gut | 2008 |
Ursodeoxycholic acid treatment improves hepatocyte ultrastructure in rat liver fibrosis
N Mas, I Tasci, B Comert, R Ocal, MR Mas |
World journal of gastroenterology : WJG | 2008 |
Z-LLY-FMK Can Attenuate Hepatocyte Apoptosis After Bile Duct Ligation in Rat
SM Sheen-Chen, HT Ho, KS Hung, HL Eng |
Digestive Diseases and Sciences | 2008 |
Bile acid levels are increased in the liver of patients with steatohepatitis
MM Aranha, H Cortez-Pinto, A Costa, IB da Silva, ME Camilo, MC de Moura, CM Rodrigues |
European Journal of Gastroenterology & Hepatology | 2008 |
Effect of Boc-D-Fmk on hepatocyte apoptosis after bile duct ligation in rat and survival rate after endotoxin challenge
SM Sheen-Chen, KS Hung, HL Eng |
Journal of Gastroenterology and Hepatology | 2008 |
Free fatty acids sensitize hepatocytes to bile acid-induced apoptosis
T Pusl, N Wild, T Vennegeerts, R Wimmer, B Göke, S Brand, C Rust |
Biochemical and Biophysical Research Communications | 2008 |
Ursodeoxycholic acid prevents apoptosis of mouse sensory neurons induced by cisplatin by reducing P53 accumulation
IH Park, MK Kim, SU Kim |
Biochemical and Biophysical Research Communications | 2008 |
Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1
T Pusl, T Vennegeerts, R Wimmer, GU Denk, U Beuers, C Rust |
Biochemical and Biophysical Research Communications | 2008 |
Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease
RM Ramalho, RJ Viana, WC Low, CJ Steer, CM Rodrigues |
Trends in Molecular Medicine | 2008 |
Ursodeoxycholic acid protects concanavalin A-induced mouse liver injury through inhibition of intrahepatic tumor necrosis factor-α and macrophage inflammatory protein-2 production
K Ishizaki, T Iwaki, S Kinoshita, M Koyama, A Fukunari, H Tanaka, M Tsurufuji, K Sakata, Y Maeda, T Imada, K Chiba |
European Journal of Pharmacology | 2008 |
Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats
A Çolak, B Kelten, A Sağmanligil, O Akdemir, A Karaoğlan, E Şahan, Ö Çelik, Ş Barut |
Journal of Clinical Neuroscience | 2008 |
Pathogenesis of Primary Biliary Cirrhosis
DE Jones |
Clinics in Liver Disease | 2008 |
Role of Mitochondria in Drug-Induced Cholestatic Injury
GE Kass, SC Price |
Clinics in Liver Disease | 2008 |
Medical Treatment of Cholestatic Liver Disease
G Paumgartner, T Pusl |
Clinics in Liver Disease | 2008 |
Tauroursodeoxycholic acid preserves photoreceptor structure and function in the rd10 mouse through post-natal day 30
MJ Phillips, TA Walker, HY Choi, AE Faulkner, MK Kim, SS Sidney, AP Boyd, JM Nickerson, JH Boatright, MT Pardue |
Investigative ophthalmology & visual science | 2008 |
Bile acid levels are increased in the liver of patients with steatohepatitis:
MM Aranha, H Cortez-Pinto, A Costa, IB da Silva, ME Camilo, MC de Moura, CM Rodrigues |
European Journal of Gastroenterology & Hepatology | 2008 |
Antibacterial and anti-atrophic effects of a highly soluble, acid stable UDCA formula in Helicobacter pylori-induced gastritis
TD Thao, HC Ryu, SH Yoo, DK Rhee |
Biochemical Pharmacology | 2008 |
Ursodeoxycholic acid treatment improves hepatocyte ultrastructure in rat liver fi brosis
N Mas, I Tasci, B Comert, R Ocal, MR Mas |
World journal of gastroenterology : WJG | 2008 |
Pathogenesis of primary biliary cirrhosis
DE Jones |
Gut | 2007 |
Soluble apoptosis molecules in primary biliary cirrhosis: analysis and commitment of the Fas and tumour necrosis factor-related apoptosis-inducing ligand systems in comparison with chronic hepatitis C
N Pelli, A Floreani, F Torre, A Delfino, A Baragiotta, P Contini, M Basso, A Picciotto |
Clinical & Experimental Immunology | 2007 |
Interaction between caspase-8 activation and endoplasmic reticulum stress in glycochenodeoxycholic acid-induced apoptotic HepG2 cells
T Iizaka, M Tsuji, H Oyamada, Y Morio, K Oguchi |
Toxicology | 2007 |
Bile acid-induced TGR5-dependent c-Jun-N terminal kinase activation leads to enhanced caspase 8 activation in hepatocytes
JI Yang, JH Yoon, SJ Myung, GY Gwak, W Kim, GE Chung, SH Lee, SM Lee, CY Kim, HS Lee |
Biochemical and Biophysical Research Communications | 2007 |
Role of Ursodeoxycholic Acid in Prevention of Methotrexate-induced Liver Toxicity
S Uraz, V Tahan, C Aygun, F Eren, G Unluguzel, M Yuksel, O Senturk, E Avsar, G Haklar, C Celikel, S Hulagu, N Tozun |
Digestive Diseases and Sciences | 2007 |
Role of mitochondria in cell death induced by Photofrin®–PDT and ursodeoxycholic acid by means of SLIM
I Kinzler, E Haseroth, C Hauser, A Rück |
Photochemical & Photobiological Sciences | 2007 |
Study of hepatocytes using RNA interference
S Niimi, M Harashima, M Hyuga, T Yamaguchi |
Journal of Organ Dysfunction | 2007 |
Protective effect of ursodeoxycholic acid on liver mitochondrial function in rats with alloxan-induced diabetes: Link with oxidative stress
O Lukivskaya, E Patsenker, VU Buko |
Life Sciences | 2007 |
Characterization of overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis according to antimitochondrial antibodies status
L Alric, S Thebault, J Selves, JM Peron, S Mejdoubi, F Fortenfant, JP Vinel |
Gastroentérologie Clinique et Biologique | 2007 |
Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis
H Robertson, JA Kirby, WW Yip, DE Jones, AD Burt |
Hepatology | 2007 |
Glycoursodeoxycholic Acid and Interleukin-10 Modulate the Reactivity of Rat Cortical Astrocytes to Unconjugated Bilirubin
A Fernandes, AR Vaz, AS Falcão, RF Silva, MA Brito, D Brites |
Journal of Neuropathology and Experimental Neurology | 2007 |
Deoxycholic Acid Can Induce Apoptosis in the Human Colon Cancer Cell Line HCT116 in the Absence of Bax
S Yui, R Kanamoto, T Saeki |
Nutrition and Cancer | 2007 |
Ursodeoxycholic Acid for the Treatment of Primary Biliary Cirrhosis
K Lindor |
New England Journal of Medicine | 2007 |
Function of nuclear steroid receptors in apoptosis: role of ursodeoxycholic acid
JD Amaral, S Solá, CJ Steer, CP Rodrigues |
Expert Review of Endocrinology & Metabolism | 2007 |
CD95 activation in the liver: Ion fluxes and oxidative signaling
R Reinehr, D Häussinger |
Archives of Biochemistry and Biophysics | 2007 |
Administration of Tauroursodeoxycholic Acid (TUDCA) Reduces Apoptosis Following Myocardial Infarction in Rat
AL Rivard, CJ Steer, BT Kren, CM Rodrigues, RE Castro, RW Bianco, WC Low |
The American journal of Chinese medicine | 2007 |
Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes
RE Castro, JD Amaral, S Solá, BT Kren, CJ Steer, CM Rodrigues |
AJP Gastrointestinal and Liver Physiology | 2007 |
Bile Acids: Biological Actions and Clinical Relevance
D Keppler, U Leuschner, M Trauner, U Beuers, A Stiehl, G Paumgartner |
2007 | |
Transcriptional regulation of metabolism
B Desvergne, L Michalik, W Wahli |
Physiological reviews | 2006 |
“Systemic apoptotic response” after thermal burns
G Gravante, D Delogu, G Sconocchia |
Apoptosis | 2006 |
17beta-estradiol prevents cytotoxicity from hydrophobic bile acids in HepG2 and WRL-68 cell cultures
M Ricchi, M Bertolotti, C Anzivino, L Carulli, I Canedi, ML Bormioli, R Tiozzo, MA Croce, A Lonardo, N Carulli, P Loria |
Journal of Gastroenterology and Hepatology | 2006 |
Rat liver fibrosis regresses better with pegylated interferon alpha2b and ursodeoxycholic acid treatments than spontaneous recovery
II Tasci, MR Mas, SA Vural, B Comert, G Alcigir, M Serdar, N Mas, AT Isik, Y Ates |
Liver International | 2006 |
Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts
M Marzioni, H Francis, A Benedetti, Y Ueno, G Fava, J Venter, R Reichenbach, MG Mancino, R Summers, G Alpini, S Glaser |
The American Journal of Pathology | 2006 |
Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice
A Ogawa, T Tagawa, H Nishimura, T Yajima, T Abe, T Arai, M Taniguchi, K Takeda, S Akira, Y Nimura, Y Yoshikai |
Gut | 2006 |
Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers
C Rust, K Bauchmuller, C Bernt, T Vennegeerts, P Fickert, A Fuchsbichler, U Beuers |
Gut | 2006 |
Involvement of endoplasmic reticulum in glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes
S Tsuchiya, M Tsuji, Y Morio, K Oguchi |
Toxicology Letters | 2006 |
Eupatilin attenuates bile acid-induced hepatocyte apoptosis
SC Park, JH Yoon, W Kim, GY Gwak, KM Kim, SH Lee, SM Lee, HS Lee |
Journal of Gastroenterology | 2006 |
Eupatilin has an antiapoptotic action on hepatocytes, in contrast to apoptotic actions on other cells
T Mine |
Journal of Gastroenterology | 2006 |
Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells
RM Ramalho, PM Borralho, RE Castro, S Sola, CJ Steer, CM Rodrigues |
Journal of Neurochemistry | 2006 |
Hepatitis C virus core protein inhibits deoxycholic acid-mediated apoptosis despite generating mitochondrial reactive oxygen species
Y Hara, K Hino, M Okuda, T Furutani, I Hidaka, Y Yamaguchi, M Korenaga, K Li, SA Weinman, SM Lemon, K Okita |
Journal of Gastroenterology | 2006 |
Maternal cholestasis induces placental oxidative stress and apoptosis. Protective effect of ursodeoxycholic acid
MJ Perez, RI Macias, JJ Marin |
Placenta | 2006 |
The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis
C Bernt, T Vennegeerts, U Beuers, C Rust |
Biochemical and Biophysical Research Communications | 2006 |
Fooling the Fas ligand in death
CM Rodrigues, CJ Steer |
Hepatology | 2006 |
Binding Studies of Bile Acids using the Native Fluorescence of the Tryptophan Residue Of Bax Protein
W Zhang, CJ Steer, KT Douglas, CM Rodrigues |
Bioscience Reports | 2006 |
Randomized Placebo-Controlled Trial of Ursodeoxycholic Acid With Vitamin E in Nonalcoholic Steatohepatitis
JF Dufour, CM Oneta, JJ Gonvers, F Bihl, A Cerny, JM Cereda, JF Zala, B Helbling, M Steuerwald, A Zimmermann |
Clinical Gastroenterology and Hepatology | 2006 |
Plasma levels of ursodeoxycholic acid in black bears, Ursus americanus: Seasonal changes
S Solá, DL Garshelis, JD Amaral, KV Noyce, PL Coy, CJ Steer, PA Iaizzo, CM Rodrigues |
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology | 2006 |
Ursodeoxycholic acid treatment of vanishing bile duct syndromes
T Pusl, U Beuers |
World journal of gastroenterology : WJG | 2006 |
Medical treatment of cholestatic liver diseases: From pathobiology to pharmacological targets
G Paumgartner |
World journal of gastroenterology : WJG | 2006 |
Functional Modulation of Nuclear Steroid Receptors by Tauroursodeoxycholic Acid Reduces Amyloid β-Peptide-Induced Apoptosis
S Solá, JD Amaral, PM Borralho, RM Ramalho, RE Castro, MM Aranha, CJ Steer, CM Rodrigues |
Molecular Endocrinology | 2006 |
A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid
RE Castro, S Solá, X Ma, RM Ramalho, BT Kren, CJ Steer, CM Rodrigues |
Journal of Hepatology | 2005 |
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans
R Ved, S Saha, B Westlund, C Perier, L Burnam, A Sluder, M Hoener, CM Rodrigues, A Alfonso, C Steer, L Liu, S Przedborski, B Wolozin |
The Journal of biological chemistry | 2005 |
Cholestatic hepatocellular injury: what do we know and how should we proceed
ME Guicciardi, GJ Gores |
Journal of Hepatology | 2005 |
Oncosis represents the main type of cell death in mouse models of cholestasis
P Fickert, M Trauner, A Fuchsbichler, G Zollner, M Wagner, HU Marschall, K Zatloukal, H Denk |
Journal of Hepatology | 2005 |
Modulation of apoptosis as a target for liver disease
ST Eichhorst |
Expert Opinion on Therapeutic Targets | 2005 |
The effect of ursodeoxycholic acid on glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes
S Utanohara, M Tsuji, S Momma, Y Morio, K Oguchi |
Toxicology | 2005 |
Bile Salt–Induced Apoptosis Involves NADPH Oxidase Isoform Activation
R Reinehr, S Becker, V Keitel, A Eberle, S Grether–Beck, D Häussinger |
Gastroenterology | 2005 |
Suppressive effect of ursodeoxycholic acid on type IIA phospholipase A2 expression in HepG2 cells
T Ikegami, Y Matsuzaki, S Fukushima, J Shoda, JL Olivier, B Bouscarel, N Tanaka |
Hepatology | 2005 |
Synthetic bile acid derivatives induce apoptosis through a c-Jun N-terminal kinase and NF-κB-dependent process in human cervical carcinoma cells
E Im, SH Choi, H Suh, YH Choi, YH Yoo, ND Kim |
Cancer Letters | 2005 |
Enteral donor pre-treatment with ursodeoxycholic acid protects the liver against ischaemia-reperfusion injury in rats
G Nowak, UG Nor�n, A Wernerson, HU Marschall, L M�ller, BG Ericzon |
Transplant International | 2005 |
Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition
LF Wang, AC Piguet, K Schmidt, T Tordjmann, JF Dufour |
Hepatology | 2005 |
Ircinin-1 induces cell cycle arrest and apoptosis in SK-MEL-2 human melanoma cells
HJ Choi, YH Choi, SB Yee, E Im, JH Jung, ND Kim |
Molecular Carcinogenesis | 2005 |
Reversible dilated cardiomyopathy associated with amphotericin B treatment
I Moyssakis, TP Vassilakopoulos, NV Sipsas, A Perakis, A Petrou, N Kosmas, GA Pangalis |
International Journal of Antimicrobial Agents | 2005 |
Oxidative stress and apoptosis in fetal rat liver induced by maternal cholestasis. Protective effect of ursodeoxycholic acid
MJ Perez, RI Macias, C Duran, MJ Monte, JM Gonzalez-Buitrago, JJ Marin |
Journal of Hepatology | 2005 |
Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes
S Solá, JD Amaral, RE Castro, RM Ramalho, PM Borralho, BT Kren, H Tanaka, CJ Steer, CM Rodrigues |
Hepatology | 2005 |
Effect of ZVAD-fmk on hepatocyte apoptosis after bile duct ligation in rat
Shyr-Ming Sheen-Chen, Hsin-Tsung Ho, Wei-Jen Chen, Hock-Liew Eng |
World journal of gastroenterology : WJG | 2005 |
Primary sclerosing cholangitis: updates in diagnosis and therapy
Piero Portincasa, Michele Vacca, Antonio Moschetta, Michele Petruzzelli, Giuseppe Palasciano, Karel J van Erpecum, Gerard P van Berge-Henegouwen |
World journal of gastroenterology : WJG | 2005 |
Primary sclerosing cholangitis: Updates in diagnosis and therapy
P Portincasa |
World journal of gastroenterology : WJG | 2005 |
Patients with primary biliary cirrhosis have increased serum total antioxidant capacity measured with the crocin bleaching assay
G Notas |
World journal of gastroenterology : WJG | 2005 |
Similar Patterns of Mitochondrial Vulnerability and Rescue Induced by Genetic Modification of α-Synuclein, Parkin, and DJ-1 in Caenorhabditis elegans
R Ved, S Saha, B Westlund, C Perier, L Burnam, A Sluder, M Hoener, CM Rodrigues, A Alfonso, C Steer, L Liu, S Przedborski, B Wolozin |
The Journal of biological chemistry | 2005 |
Hypothermic Maintenance of Hepatocyte Spheroids
PH Lai, Q Meng, TD Sielaff, WS Hu |
Cell Transplantation | 2005 |
Characteristics of Apoptosis in HCT116 Colon Cancer Cells Induced by Deoxycholic Acid
S Yui, T Saeki, R Kanamoto, K Iwami |
Journal of Biochemistry | 2005 |
Phosphatidylinositol 3-kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers
C Rust, K Bauchmuller, P Fickert, A Fuchsbichler, U Beuers |
AJP Gastrointestinal and Liver Physiology | 2005 |
Role for Membrane Fluidity in Ethanol-Induced Oxidative Stress of Primary Rat Hepatocytes
O Sergent, M Pereira, C Belhomme, M Chevanne, L Huc, D Lagadic-Gossmann |
The Journal of pharmacology and experimental therapeutics | 2005 |
Gastroenterology Yesterday — Today — Tomorrow: A Review and Preview
G Adler, HE Blum, MP Manns, RB Sartor, AL Blum, U Leuschner, J Mössner, J Schölmerich |
2005 | |
Bile Acid Biology and its Therapeutic Implications
G Paumgartner, D Keppler, U Leuschner, A Stiehl |
2005 | |
Medical Treatment of Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis
C Rust, U Beuers |
Clinical Reviews in Allergy & Immunology | 2005 |
Patients with primary biliary cirrhosis have increased serum total antioxidant capacity measured with the crocin bleaching assay.
Notas G, Miliaraki N, Kampa M, Dimoulios F, Matrella E, Hatzidakis A, Castanas E, Kouroumalis E |
World Journal of Gastroenterology | 2005 |
The cellular biochemistry of cholesterol and statins: insights into the pathophysiology and therapy of Alzheimer's disease.
Wolozin B, Brown J 3rd, Theisler C, Silberman S |
CNS Drug Reviews | 2004 |
Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress
G Serviddio, J Pereda, FV Pallard�, J Carretero, C Borras, J Cutrin, G Vendemiale, G Poli, J Vi�a, J Sastre |
Hepatology | 2004 |
The Cellular Biochemistry of Cholesterol and Statins: Insights into the Pathophysiology and Therapy of Alzheimer's Disease
B Wolozin, J Brown, C Theisler, S Silberman |
CNS Drug Reviews | 2004 |
Glutathione-S-transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid
A Nobuoka, T Takayama, K Miyanishi, T Sato, K Takanashi, T Hayashi, T Kukitsu, Y Sato, M Takahashi, T Okamoto, T Matsunaga, J Kato, M Oda, T Azuma, Y Niitsu |
Gastroenterology | 2004 |
Bile salt-induced apoptosis in human colon cancer cell lines involves the mitochondrial transmembrane potential but not the CD95 (Fas/Apo-1) receptor
FP Wachs, RC Krieg, CM Rodrigues, H Messmann, F Kullmann, R Kn�chel-Clarke, J Sch�lmerich, G Rogler, K Schlottmann |
International Journal of Colorectal Disease | 2004 |
Mitochondrially-mediated toxicity of bile acids
CM Palmeira, AP Rolo |
Toxicology | 2004 |
Involvement of the Src family kinase yes in bile salt-induced apoptosis
R Reinehr, S Becker, M Wettstein, D Häussinger |
Gastroenterology | 2004 |
Reduced oncotic necrosis in fas receptor-deficient C57BL/6J-lpr mice after bile duct ligation
JS Gujral, J Liu, A Farhood, H Jaeschke |
Hepatology | 2004 |
Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways
MH Schoemaker, LC de la Rosa, M Buist-Homan, TE Vrenken, R Havinga, K Poelstra, HJ Haisma, PL Jansen, H Moshage |
Hepatology | 2004 |
Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes
SI Han, E Studer, S Gupta, Y Fang, L Qiao, W Li, S Grant, PB Hylemon, P Dent |
Hepatology | 2004 |
Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95
R Reinehr, D Häussinger |
Gastroenterology | 2004 |
Effect of oral ursodeoxycholic acid on bile acids tolerance tests in healthy dogs
L Abraham, J Charles, S Holloway |
Australian Veterinary Journal | 2004 |
β-Carotene Prevents Bile Acid-Induced Cytotoxicity in the Rat Hepatocyte: Evidence for an Antioxidant and Anti-Apoptotic Role of β-Carotene In Vitro
E Gumpricht, R Dahl, MW Devereaux, RJ Sokol |
Pediatric Research | 2004 |
Metabolic, antioxidant, nutraceutical, probiotic, and herbal therapies relating to the management of hepatobiliary disorders
SA Center |
Veterinary Clinics of North America Small Animal Practice | 2004 |
Transporteurs biliaires : de la génétique à la clinique
O Rosmorduc, R Poupon |
Gastroentérologie Clinique et Biologique | 2004 |
Toxicity of ethanol and acetaldehyde in hepatocytes treated with ursodeoxycholic or tauroursodeoxycholic acid
K Henzel, C Thorborg, M Hofmann, G Zimmer, U Leuschner |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2004 |
Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease
J Brown, C Theisler, S Silberman, D Magnuson, N Gottardi-Littell, JM Lee, D Yager, J Crowley, K Sambamurti, MM Rahman, AB Reiss, CB Eckman, B Wolozin |
The Journal of biological chemistry | 2004 |
A mechanism for the proapoptotic activity of ursodeoxycholic acid: effects on Bcl-2 conformation
M Castelli, JJ Reiners, D Kessel |
Cell Death and Differentiation | 2004 |
Ursodeoxycholic Acid (UDCA) Can Inhibit Deoxycholic Acid (DCA)-induced Apoptosis via Modulation of EGFR/Raf-1/ERK Signaling in Human Colon Cancer Cells
E Im, JD Martinez |
The Journal of nutrition | 2004 |
The cellular biochemistry of cholesterol and statins: insights into the pathophysiology and therapy of Alzheimer's disease
Benjamin Wolozin, James Brown 3rd, Catherine Theisler, Simone Silberman |
CNS Drug Reviews | 2004 |
Ursodeoxycholate further increases bile-duct cell proliferative response induced by partial bile-duct ligation in rats
M Barone, E Maiorano, R Ladisa, A Pece, P Berloco, M Strazzabosco, ML Caruso, AM Valentini, E Ierardi, AD Leo, A Francavilla |
Virchows Archiv | 2004 |
Ursodeoxycholic Acid Ameliorates Experimental Ileitis Counteracting Intestinal Barrier Dysfunction and Oxidative Stress
CF Bernardes-Silva, AO Damião, AM Sipahi, FR Laurindo, K Iriya, FP Lopasso, CA Buchpiguel, ML Lordello, CL Agostinho, AA Laudanna |
Digestive Diseases and Sciences | 2004 |
Bile salt-induced apoptosis in human colon cancer cell lines involves the mitochondrial transmembrane potential but not the CD95 (Fas/Apo-1) receptor
FP Wachs, RC Krieg, CM Rodrigues, H Messmann, F Kullmann, R Knchel-Clarke, J Schlmerich, G Rogler, K Schlottmann |
International Journal of Colorectal Disease | 2004 |
Effect of Glutamine and Bile Acid on Hepatocyte Apoptosis after Bile Duct Ligation in the Rat
SM Sheen-Chen, KS Hung, HT Ho, WJ Chen, HL Eng |
World Journal of Surgery | 2004 |
Primary sclerosing cholangitis
S Cullen, R Chapman |
Autoimmunity Reviews | 2003 |
Bilirubin inhibits bile acid induced apoptosis in rat hepatocytes
A Granato, G Gores, MT Vilei, R Tolando, C Ferraresso, M Muraca |
Gut | 2003 |
Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats
CM Rodrigues, S Sola, Z Nan, RE Castro, PS Ribeiro, WC Low, CJ Steer |
Proceedings of the National Academy of Sciences | 2003 |
Bilirubin, a curse and a boon
JD Ostrow, C Tiribelli |
Gut | 2003 |
Bile salt—induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation
R Reinehr, D Graf, D Häussinger |
Gastroenterology | 2003 |
Apoptosis and modulation of cell cycle control by synthetic derivatives of ursodeoxycholic acid and chenodeoxycholic acid in human prostate cancer cells
YH Choi, EO Im, H Suh, Y Jin, YH Yoo, ND Kim |
Cancer Letters | 2003 |
Circulating soluble cytochrome c in liver disease as a marker of apoptosis
Z Ben-Ari, H Schmilovotz-Weiss, A Belinki, O Pappo, J Sulkes, MG Neuman, E Kaganovsky, B Kfir, R Tur-Kaspa, T Klein |
Journal of Internal Medicine | 2003 |
Current aspects of pharmacologic application of bile acids
M Mikov, KK N., JK E. |
Medicinski pregled | 2003 |
The effect of ursodeoxycholic acid on the survivin in thapsigargin-induced apoptosis
J Sohn, VI Khaoustov, Q Xie, CC Chung, B Krishnan, B Yoffe |
Cancer Letters | 2003 |
Ursodeoxycholic acid inhibits pro-inflammatory repertoires, IL-1β and nitric oxide in rat microglia
SS Joo, HC Kang, TJ Won, DI Lee |
Archives of Pharmacal Research | 2003 |
Cytotoxic mechanisms of hydrosulfide anion and cyanide anion in primary rat hepatocyte cultures
RW Thompson, HL Valentine, WM Valentine |
Toxicology | 2003 |
Treatment of primary sclerosing cholangitis with low-dose ursodeoxycholic acid: results of a retrospective Italian multicentre survey
L Okolicsanyi, M Groppo, A Floreani, AM Morselli-Labate, AG Rusticali, A Battocchia, M Colombo, G Galatola, G Gasbarrini, M Podda, G Ricci, F Rosina, M Zuin |
Digestive and Liver Disease | 2003 |
Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation
MH Schoemaker, WM Gommans, LC de la Rosa, M Homan, P Klok, C Trautwein, H Goor, K Poelstra, HJ Haisma, PL Jansen, H Moshage |
Journal of Hepatology | 2003 |
Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratins
P Fickert, M Trauner, A Fuchsbichler, C Stumptner, K Zatloukal, H Denk |
Journal of Hepatology | 2003 |
Inhibition of taurolithocholate 3-sulfate-induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and -independent mechanisms
D Graf, R Reinehr, AK Kurz, R Fischer, D Häussinger |
Archives of Biochemistry and Biophysics | 2003 |
Current management of primary biliary cirrhosis and primary sclerosing cholangitis
C Levy, KD Lindor |
Journal of Hepatology | 2003 |
Combined analysis of the effect of treatment with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis
RE Poupon, KD Lindor, A Parés, O Chazouillères, R Poupon, EJ Heathcote |
Journal of Hepatology | 2003 |
Challenges in IBD Research: Updating the Scientific Agendas:
CO Elson, RB Sartor, SR Targan, WJ Sandborn |
Inflammatory Bowel Diseases | 2003 |
Mitochondrially mediated synergistic cell killing by bile acids
Anabela P Rolo, Carlos M Palmeira, Kendall B Wallace |
Biochimica et Biophysica Acta | 2003 |
Bile Acids Up-regulate Death Receptor 5/TRAIL-receptor 2 Expression via a c-Jun N-terminal Kinase-dependent Pathway Involving Sp1
H Higuchi, A Grambihler, A Canbay, SF Bronk, GJ Gores |
The Journal of biological chemistry | 2003 |
cFLIP-L Inhibits p38 MAPK Activation: AN ADDITIONAL ANTI-APOPTOTIC MECHANISM IN BILE ACID-MEDIATED APOPTOSIS
A Grambihler, H Higuchi, SF Bronk, GJ Gores |
The Journal of biological chemistry | 2003 |
Ursodeoxycholic Acid Modulates E2F-1 and p53 Expression through a Caspase-independent Mechanism in Transforming Growth Factor β1-induced Apoptosis of Rat Hepatocytes
S Solá, X Ma, RE Castro, BT Kren, CJ Steer, CM Rodrigues |
The Journal of biological chemistry | 2003 |
Influence of ursodeoxycholate-enriched diet on liver tumor growth in HBV transgenic mice
M Barone |
Hepatology | 2003 |
Klinische Hepatologie
H Dancygier |
2003 | |
Role of apoptosis in the remodeling of cholestatic liver injury following release of the mechanical stress
AM Costa, B Tuchweber, T Lamireau, IM Yousef, C Balabaud, J Rosenbaum, A Desmoulière |
Virchows Archiv | 2003 |
Tauroursodeoxycholic Acid Prevents Amyloid-β Peptide-Induced Neuronal Death Via a Phosphatidylinositol 3-Kinase-Dependent Signaling Pathway
S Solá, RE Castro, PA Laires, CJ Steer, CM Rodrigues |
Molecular Medicine | 2003 |
Mécanismes moléculaires de la formation de la bile et des maladies cholestatiques
R Poupon |
Bulletin de l'Académie nationale de médecine | 2003 |
Unique Inhibition of Bile Salt-Induced Apoptosis by Lecithins and Cytoprotective Bile Salts in Immortalized Mouse Cholangiocytes
D Komichi, S Tazuma, T Nishioka, H Hyogo, M Une, K Chayama |
Digestive Diseases and Sciences | 2003 |
The management of primary sclerosing cholangitis
RW Chapman |
Current Gastroenterology Reports | 2003 |
Multifunctional Role of Fas-Associated Death Domain Protein in Apoptosis
KS Kim |
Journal of Biochemistry and molecular biology | 2002 |
Synthetic Bile Acids: Novel Mediators of Apoptosis
ND Kim, EO Im, YH Choi, YH Yoo |
Journal of Biochemistry and molecular biology | 2002 |
Cholestasis induces murine hepatocyte apoptosis and DNA synthesis with preservation of the immediate-early gene response
MA Bird, PA Lange, LW Schrum, JW Grisham, RA Rippe, KE Behrns |
Surgery | 2002 |
Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways
P Milkiewicz, MG Roma, E Elias, R Coleman |
Gut | 2002 |
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease
CD Keene, CM Rodrigues, T Eich, MS Chhabra, CJ Steer, WC Low |
Proceedings of the National Academy of Sciences | 2002 |
Interactions of combined bile acids on hepatocyte viability: cytoprotection or synergism
AP Rolo, CM Palmeira, KB Wallace |
Toxicology Letters | 2002 |
Endotoxin potentiates hepatocyte apoptosis in cholestasis1 1No competing interests declared
FN Moazzam, JJ Brems, SL Yong, JP Filkins, SG Fisher, DR Holt, RL Gamelli, JW Ding |
Journal of the American College of Surgeons | 2002 |
Bile acid-mediated hepatocyte apoptosis and cholestatic liver disease
ME Guicciardi, GJ Gores |
Digestive and Liver Disease | 2002 |
Use of ursodeoxycholic acid in patients with liver disease
P Angulo |
Current Gastroenterology Reports | 2002 |
Liver Cell Injury and Fibrosis
RJ Sokol |
Journal of Pediatric Gastroenterology and Nutrition | 2002 |
Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis
J Tinmouth, M Lee, IR Wanless, FW Tsui, R Inman, EJ Heathcote |
Liver International | 2002 |
Neuroprotection by a Bile Acid in an Acute Stroke Model in the Rat
CM Rodrigues, SR Spellman, S Sol??, AW Grande, C Linehan-Stieers, WC Low, CJ Steer |
Journal of Cerebral Blood Flow & Metabolism | 2002 |
Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order, and redox status in rat mitochondria
C Rodrigues |
Journal of Hepatology | 2002 |
Aging Confers Different Sensitivity to the Neurotoxic Properties of Unconjugated Bilirubin
CM Rodrigues, S Solá, RF Silva, D Brites |
Pediatric Research | 2002 |
Induction and Regulation of Hepatocyte Apoptosis by Oxidative Stress
MJ Czaja |
Antioxidants & Redox Signaling | 2002 |
Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase–dependent manner
D Graf, AK Kurz, R Fischer, R Reinehr, D Häussinger |
Gastroenterology | 2002 |
Nitric Oxide Ameliorates Hydrophobic Bile Acid-induced Apoptosis in Isolated Rat Hepatocytes by Non-mitochondrial Pathways
E Gumpricht, R Dahl, B Yerushalmi, MW Devereaux, RJ Sokol |
The Journal of biological chemistry | 2002 |
Ursodeoxycholic acid cytoprotection: Dancing with death receptors and survival pathways
M Guicciardi |
Hepatology | 2002 |
Primary biliary cirrhosis with additional features of autoimmune hepatitis: Response to therapy with ursodeoxycholic acid
S Joshi |
Hepatology | 2002 |
S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells
E Ansorena |
Hepatology | 2002 |
cAMP inhibits bile acid-induced apoptosis by blocking caspase activation and cytochrome c release
CR Webster, P Usechak, MS Anwer |
AJP Gastrointestinal and Liver Physiology | 2002 |
Ursodeoxycholic acid diminishes Fas-ligand–induced apoptosis in mouse hepatocytes
F Azzaroli |
Hepatology | 2002 |
Prevention of bile acid–induced apoptosis by betaine in rat liver
D Graf |
Hepatology | 2002 |
Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons
C Rodrigues |
Hepatology | 2002 |
Tauroursodeoxycholic Acid Improves the Survival and Function of Nigral Transplants in a Rat Model of Parkinson's Disease
WM Duan, CM Rodrigures, LR Zhao, CJ Steer, WC Low |
Cell Transplantation | 2002 |
Review of Methods to Remove Protein-Bound Substances in Liver Failure
RD Hughes |
The International Journal of Artificial Organs | 2002 |
Intrahepatic cholestasis of pregnancy: Changes in maternal-fetal bile acid balance and improvement by ursodeoxycholic acid
D Brites |
ANN HEPATOL | 2002 |
Use of ursodeoxycholic acid in liver diseases
D Kumar, RK Tandon |
Journal of Gastroenterology and Hepatology | 2001 |
An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity
S Fiorucci, A Mencarelli, B Palazzetti, PD Soldato, A Morelli, LJ Ignarro |
Proceedings of the National Academy of Sciences | 2001 |
Bile-salt hydrophobicity is a key factor regulating rat liver plasma-membrane communication: relation to bilayer structure, fluidity and transporter expression and function
Y Asamoto, S Tazuma, H Ochi, K Chayama, H Suzuki |
Biochemical Journal | 2001 |
Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis
R Wang, M Salem, IM Yousef, B Tuchweber, P Lam, SJ Childs, CD Helgason, C Ackerley, MJ Phillips, V Ling |
Proceedings of the National Academy of Sciences | 2001 |
NF-kappaB is activated in cholestasis and functions to reduce liver injury
H Miyoshi, C Rust, ME Guicciardi, GJ Gores |
The American Journal of Pathology | 2001 |
The therapeutic effects of ursodeoxycholic acid as an anti-apoptotic agent
CM Rodrigues, CJ Steer |
Expert Opinion on Investigational Drugs | 2001 |
Primary biliary cirrhosis: modalities of injury and death in biliary epithelium
L Marucci, L Ugili, G Macarri, G Feliciangeli, E Bendia, AM Jezequel, F Orlandi, A Benedetti |
Digestive and Liver Disease | 2001 |
NF-κB Is Activated in Cholestasis and Functions to Reduce Liver Injury
H Miyoshi, C Rust, ME Guicciardi, GJ Gores |
The American Journal of Pathology | 2001 |
Drug therapy of primary biliary diseases: classical and modern strategies
J Schlichting, U Leuschner |
Journal of Cellular and Molecular Medicine | 2001 |
Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cells
E Im, YH Choi, KJ Paik, H Suh, Y Jin, KW Kim, YH Yoo, ND Kim |
Cancer Letters | 2001 |
A Bile Acid Protects against Motor and Cognitive Deficits and Reduces Striatal Degeneration in the 3-Nitropropionic Acid Model of Huntington's Disease
CD Keene, CM Rodrigues, T Eich, C Linehan-Stieers, A Abt, BT Kren, CJ Steer, WC Low |
Experimental Neurology | 2001 |
Ursodeoxycholic acid ‘mechanisms of action and clinical use in hepatobiliary disorders’
KN Lazaridis, GJ Gores, KD Lindor |
Journal of Hepatology | 2001 |
Creatine-supplemented diet extends Purkinje cell survival in spinocerebellar ataxia type 1 transgenic mice but does not prevent the ataxic phenotype
WF Kaemmerer, CM Rodrigues, CJ Steer, WC Low |
Neuroscience | 2001 |
Clinical and biological relevance of hepatocyte apoptosis in alcoholic hepatitis
M Ziol, M Tepper, M Lohez, G Arcangeli, N Ganne, C Christidis, JC Trinchet, M Beaugrand, JG Guillet, C Guettier |
Journal of Hepatology | 2001 |
Agmatine induces apoptosis in rat hepatocyte cultures
G Gardini, C Cabella, C Cravanzola, C Vargiu, S Belliardo, G Testore, SP Solinas, A Toninello, MA Grillo, S Colombatto |
Journal of Hepatology | 2001 |
Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid
RF Silva, CM Rodrigues, D Brites |
Journal of Hepatology | 2001 |
Amyloid β-Peptide Disrupts Mitochondrial Membrane Lipid and Protein Structure: Protective Role of Tauroursodeoxycholate
CM Rodrigues, S Solá, MA Brito, CD Brondino, D Brites, JJ Moura |
Biochemical and Biophysical Research Communications | 2001 |
Apoptosis in Diseases of the Liver
MG Neuman |
Critical Reviews in Clinical Laboratory Sciences | 2001 |
Apoptose como mecanismo de lesão nas doenças hepatobiliares
MB PAROLIN, IJ REASON |
Arquivos de Gastroenterologia | 2001 |
The Bile Acid Glycochenodeoxycholate Induces TRAIL-Receptor 2/DR5 Expression and Apoptosis
H Higuchi, SF Bronk, Y Takikawa, N Werneburg, R Takimoto, W El-Deiry, GJ Gores |
The Journal of biological chemistry | 2001 |
Functional Modulation of the Glucocorticoid Receptor and Suppression of NF-κB-dependent Transcription by Ursodeoxycholic Acid
T Miura, R Ouchida, N Yoshikawa, K Okamoto, Y Makino, T Nakamura, C Morimoto, I Makino, H Tanaka |
The Journal of biological chemistry | 2001 |
Modulation of steady-state messenger RNA levels in the regenerating rat liver with bile acid feeding
BT Kren, CM Rodrigues, KD Setchell, CJ Steer |
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society | 2001 |
Deoxycholic Acid (DCA) Causes Ligand-independent Activation of Epidermal Growth Factor Receptor (EGFR) and FAS Receptor in Primary Hepatocytes: Inhibition of EGFR/Mitogen-activated Protein Kinase-Signaling Module Enhances DCA-induced Apoptosis
L Qiao, E Studer, K Leach, R McKinstry, S Gupta, R Decker, R Kukreja, K Valerie, P Nagarkatti, WE Deiry, J Molkentin, R Schmidt-Ullrich, PB Fisher, S Grant, PB Hylemon, P Dent, CH Heldin |
Molecular biology of the cell | 2001 |
Geranylgeraniol, an intermediate product in mevalonate pathway, induces apoptotic cell death in human hepatoma cells: death receptor-independent activation of caspase-8 with down-regulation of Bcl-xL expression
Y Takeda, K Nakao, K Nakata, A Kawakami, H Ida, T Ichikawa, M Shigeno, Y Kajiya, K Hamasaki, Y Kato, K Eguchi |
Japanese journal of cancer research : Gann | 2001 |
PROTECTIVE ROLE OF TAUROURSODEOXYCHOLATE DURING HARVESTING AND COLD STORAGE OF HUMAN LIVER: A Pilot Study in Transplant Recipients1
L Falasca, G Tisone, G Palmieri, A Anselmo, DD Paolo, L Baiocchi, E Torri, G Orlando, CU Casciani, M Angelico |
Transplantation | 2001 |
Chronisch entzündliche Darmerkrankungen
J Stein, A Dignass |
2001 | |
Ursodeoxycholic acid and in vitro vasoactivity of hydrophobic bile acids
A Bomzon, P Ljubuncic |
Digestive Diseases and Sciences | 2001 |
Geranylgeraniol, an intermediate product in mevalonate pathway, induces apoptotic cell death in human hepatoma cells: death receptor-independent activation of caspase-8 with down-regulation of Bcl-xL expression.
Takeda Y, Nakao K, Nakata K, Kawakami A, Ida H, Ichikawa T, Shigeno M, Kajiya Y, Hamasaki K, Kato Y, Eguchi K |
Japanese journal of cancer research : Gann | 2001 |
Pathophysiology of the intrahepatic biliary epithelium
M Strazzabosco, C Spirli, L Okolicsanyi |
Journal of Gastroenterology and Hepatology | 2000 |
Genipin, a metabolite derived from the herbal medicine Inchin-ko-to, and suppression of Fas-induced lethal liver apoptosis in mice
M Yamamoto, N Miura, N Ohtake, S Amagaya, A Ishige, H Sasaki, Y Komatsu, K Fukuda, T Ito, K Terasawa |
Gastroenterology | 2000 |
Apoptotic cell death does not parallel other indicators of liver damage in chronic hepatitis C patients
Rodrigues, Brites, Serejo, Costa, Ramalho, M. Carneiro de Moura |
Journal of Viral Hepatitis | 2000 |
The Japanese multicenter open randomized trial of ursodeoxycholic acid prophylaxis for hepatic veno-occlusive disease after stem cell transplantation
K Ohashi, J Tanabe, R Watanabe, T Tanaka, H Sakamaki, A Maruta, S Okamoto, N Aotsuka, K Saito, M Nishimura, H Oh, M Matsuzaki, S Takahashi, S Yonekura |
American Journal of Hematology | 2000 |
Attenuation of Alcohol-Induced Apoptosis of Hepatocytes in Rat Livers by Polyenylphosphatidylcholine (PPC)
LJ Mi, KM Mak, CS Lieber |
Alcoholism, clinical and experimental research | 2000 |
Effects of specific bile acids on c-fos messenger RNA levels in human colon carcinoma Caco-2 cells
RD Toro, G Campana, G Murari, S Spampinato |
European Journal of Pharmaceutical Sciences | 2000 |
Tauroursodeoxycholic Acid Partially Prevents Apoptosis Induced by 3-Nitropropionic Acid
CM Rodrigues, CL Stieers, CD Keene, X Ma, BT Kren, WC Low, CJ Steer |
Journal of Neurochemistry | 2000 |
Mechanisms of liver cell injury
N Kaplowitz |
Journal of Hepatology | 2000 |
Apoptosis and liver disease
C Rust, GJ Gores |
The American Journal of Medicine | 2000 |
Ursodeoxycholic acid to inhibit the growth of hepatic metastases
BD Keith |
Medical Hypotheses | 2000 |
APOPTOSIS IN HEPATIC PATHOPHYSIOLOGY
T Patel |
Clinics in Liver Disease | 2000 |
CELL DEATH AT THE MILLENNIUM
N Kaplowitz |
Clinics in Liver Disease | 2000 |
Mitochondrial control of cell death
G Kroemer, JC Reed |
Nature Medicine | 2000 |
Chronic cholestatic diseases
R Poupon, O Chazouillères, RE Poupon |
Journal of Hepatology | 2000 |
Ursodeoxycholic acid for primary biliary cirrhosis: lessons from the pastissues for the future
RE Poupon |
Journal of Hepatology | 2000 |
Mitochondrial membrane perturbations in cholestasis
CM Rodrigues, CJ Steer |
Journal of Hepatology | 2000 |
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
CJ Sinal, M Tohkin, M Miyata, JM Ward, G Lambert, FJ Gonzalez |
Cell | 2000 |
THE CELL AND MOLECULAR BIOLOGY OF HEPATIC FIBROGENESIS
DC Rockey |
Clinics in Liver Disease | 2000 |
The NAD+ precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate
CL Crowley, CM Payne, H Bernstein, C Bernstein, D Roe |
Cell Death and Differentiation | 2000 |
Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas
T Sodeman, SF Bronk, PJ Roberts, H Miyoshi, GJ Gores |
AJP Gastrointestinal and Liver Physiology | 2000 |
Soluble Fas is increased in serum of patients with primary biliary cirrhosis, but is not a useful marker for disease activity
J Gozlan, I Nion, O Chazouilleres, Y Chretien, R Poupon |
The American Journal of Gastroenterology | 2000 |
Bilirubin and Amyloid-β Peptide Induce Cytochrome c Release Through Mitochondrial Membrane Permeabilization
CM Rodrigues, S Solá, R Silva, D Brites |
Molecular Medicine | 2000 |
Immunology and Liver
MP Manns, G Paumgartner, U Leuschner |
2000 | |
Apoptosis and Its Modulation by Drugs
RG Cameron, G Feuer |
2000 | |
Attenuation of Alcohol-Induced Apoptosis of Hepatocytes in Rat Livers by Polyenylphosphatidylcholine (PPC):
LJ Mi, KM Mak, CS Lieber |
Alcoholism, clinical and experimental research | 2000 |
Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity
B Gonzalez, C Fisher, B G Rosser |
Molecular and Cellular Biochemistry | 2000 |
Ursodeoxycholic acid suppresses extent of lipid peroxidation in diseased liver in experimental cholestatic liver disease
P Ljubuncic, Z Tanne, A Bomzon |
Digestive Diseases and Sciences | 2000 |
The significance of apoptosis in the liver
A Benedetti, L Marucci |
Liver International | 1999 |
Cellular and molecular biology of the liver
SJ Karpen, JM Crawford |
Current Opinion in Gastroenterology | 1999 |
Cholestatic syndromes
M Trauner, JL Boyer |
Current Opinion in Gastroenterology | 1999 |
Bile acids and hepatocyte apoptosis: Living/leaving life in the Fas lane
CM Rodrigues, CJ Steer |
Gastroenterology | 1999 |
Review article: mechanisms of action and therapeutic applications of ursodeoxycholic acid in chronic liver diseases
Trauner, Graziadei |
Alimentary Pharmacology & Therapeutics | 1999 |
Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas
H Miyoshi, C Rust, PJ Roberts, LJ Burgart, GJ Gores |
Gastroenterology | 1999 |
Cholestatic syndromes:
M Trauner, JL Boyer |
Current Opinion in Gastroenterology | 1999 |
Biliary bile acids in primary biliary cirrhosis: effect of ursodeoxycholic acid
B Combes, RL Carithers, WC Maddrey, S Munoz, G Garcia-Tsao, GF Bonner, JL Boyer, VA Luketic, ML Shiffman, MG Peters, H White, RK Zetterman, R Risser, SS Rossi, AF Hofmann |
Hepatology | 1999 |
Ursodeoxycholic acid as adjunctive therapy for problematic type 1 autoimmune hepatitis: A randomized placebo-controlled treatment trial
AJ Czaja, HA Carpenter, KD Lindor |
Hepatology | 1999 |
Molecular Pathogenesis of Cholestasis
FH Epstein, M Trauner, PJ Meier, JL Boyer |
New England Journal of Medicine | 1998 |
Principles of Medical Biology
JO Jørgensen |
Principles of Medical Biology | 1998 |