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Citations to this article

Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival
David T. Denhardt, … , Dubravko Pavlin, Jeffrey S. Berman
David T. Denhardt, … , Dubravko Pavlin, Jeffrey S. Berman
Published May 1, 2001
Citation Information: J Clin Invest. 2001;107(9):1055-1061. https://doi.org/10.1172/JCI12980.
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Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival

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Abstract

Authors

David T. Denhardt, Masaki Noda, Anthony W. O’Regan, Dubravko Pavlin, Jeffrey S. Berman

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Fardoun, Iratni, Dehaini, Eid, Ghaddar, EE, Alali, Badran, Eid, Baydoun
Biomolecules 2019
Differential sensitivity of inbred mouse strains to ovarian damage in response to low-dose total body irradiation†
N Quan, LR Harris, R Halder, CV Trinidad, BW Johnson, S Horton, BF Kimler, MT Pritchard, FE Duncan
Biology of reproduction 2019
Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis
M Krstic, HM Hassan, B Kolendowski, MN Hague, PH Anborgh, CO Postenka, J Torchia, AF Chambers, AB Tuck
Laboratory Investigation 2019
Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk
MF Landecho, C Tuero, V Valentí, I Bilbao, M de la Higuera, G Frühbeck
Nutrients 2019
Osteopontin controls immunosuppression in the tumor microenvironment
Michael Shurin
Journal of Clinical Investigation 2018
Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis
N Graham, BZ Qian
International journal of molecular sciences 2018
Osteopontin plays a pivotal role in increasing severity of respiratory syncytial virus infection
V Sampayo-Escobar, R Green, MB Cheung, R Bedi, S Mohapatra, SS Mohapatra, SA Cormier
PloS one 2018
Acute-Phase Plasma Osteopontin as an Independent Predictor for Poor Outcome After Aneurysmal Subarachnoid Hemorrhage
Y Nakatsuka, M Shiba, H Nishikawa, M Terashima, F Kawakita, M Fujimoto, H Suzuki
Molecular Neurobiology 2018
Regulatory Roles of Osteopontin in Production of Monocyte-Origin MCP-1
L Shi, L Shi, X Wang, J He
Cell Transplantation 2018
Methylglyoxal-bis-guanylhydrazone inhibits osteopontin expression and differentiation in cultured human monocytes
X Jin, H Xu, MS McGrath, A Haziot
PloS one 2018
Progress of Regenerative Therapy in Orthopedics
Pearlin, S Nayak, G Manivasagam, D Sen
Current Osteoporosis Reports 2018
Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: A systematic review and meta-analysis
E Agah, A Zardoui, A Saghazadeh, M Ahmadi, A Tafakhori, N Rezaei, H Wiendl
PloS one 2018
Multifarious Biologic Loaded Liposomes that Stimulate the Mammalian Target of Rapamycin Signaling Pathway Show Retina Neuroprotection after Retina Damage
AZ Eriksen, R Eliasen, J Oswald, PJ Kempen, F Melander, TL Andresen, M Young, P Baranov, AJ Urquhart
ACS Nano 2018
Different Effects of Global Osteopontin and Macrophage Osteopontin in Glomerular Injury
J Trostel, LD Truong, CA Roncal-Jimenez, M Miyazaki, S Miyazaki-Anzai, M Kuwabara, RH McMahan, A Andres-Hernando, Y Sato, T Jensen, MA Lanaspa, RJ Johnson, GE Garcia
American journal of physiology. Renal physiology 2018
The Phylogeny of Osteopontin—Analysis of the Protein Sequence
GF Weber
International journal of molecular sciences 2018
Osteopontin Attenuates Secondary Neurodegeneration in the Thalamus after Experimental Stroke
A Ladwig, R Rogall, J Hucklenbroich, A Willuweit, M Schoeneck, KJ Langen, GR Fink, MA Rueger, M Schroeter
Journal of Neuroimmune Pharmacology 2018
Recombinant Osteopontin Improves Neurological Functional Recovery and Protects Against Apoptosis via PI3K/Akt/GSK-3β Pathway Following Intracerebral Hemorrhage.
Zhang W, Cui Y, Gao J, Li R, Jiang X, Tian Y, Wang K, Cui J
Medical science monitor : international medical journal of experimental and clinical research 2018
Monocyte Chemotactic Protein-1–Interleukin-6–Osteopontin Pathway of Intra-Aneurysmal Tissue Healing
K Hosaka, K Rojas, HZ Fazal, MB Schneider, J Shores, V Federico, M McCord, L Lin, B Hoh
Stroke; a journal of cerebral circulation 2017
Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME): study protocol for a randomised controlled trial
SE Rowbotham, D Cavaye, R Jaeggi, JS Jenkins, CS Moran, JV Moxon, JL Pinchbeck, F Quigley, CM Reid, J Golledge
Trials 2017
The association between osteopontin gene polymorphisms, osteopontin expression and sarcoidosis
H Lavi, M Assayag, A Schwartz, N Arish, ZG Fridlender, N Berkman, GR Wallace
PloS one 2017
Cellular and Molecular Pathways Leading to External Root Resorption
A Iglesias-Linares, JK Hartsfield
Journal of dental research 2017
Potent pro-inflammatory and pro-fibrotic molecules, osteopontin and galectin-3, are not major disease modulators of laminin α2 chain-deficient muscular dystrophy
KI Gawlik, J Holmberg, M Svensson, M Einerborg, BM Oliveira, T Deierborg, M Durbeej
Scientific Reports 2017
CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives
L Cortes-Dericks, RA Schmid
Respiratory Research 2017
Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-β1 activation and myofibroblast differentiation
J Dong, Q Ma
Particle and Fibre Toxicology 2017
Urinary Osteopontin Predicts Incident Chronic Kidney Disease, while Plasma Osteopontin Predicts Cardiovascular Death in Elderly Men
T Feldreich, AC Carlsson, J Helmersson-Karlqvist, U Risérus, A Larsson, L Lind, J Ärnlöv
Cardiorenal Medicine 2017
Transcriptome analysis for the identification of cellular markers related to trabecular meshwork differentiation
P Sathiyanathan, CY Tay, LW Stanton
BMC Genomics 2017
The Effect of Osteopontin on Microglia
H Yu, X Liu, Y Zhong
BioMed Research International 2017
Combined analysis of the pre- and postoperative neutrophil–lymphocyte ratio predicts the outcomes of patients with gastric cancer
K Miyatani, H Saito, Y Kono, Y Murakami, H Kuroda, T Matsunaga, Y Fukumoto, T Osaki, K Ashida, Y Fujiwara
Surgery Today 2017
The Retina of Osteopontin deficient Mice in Aging
N Ruzafa, X Pereiro, P Aspichueta, J Araiz, E Vecino
Molecular Neurobiology 2017
The role of α9β1 integrin and its ligands in the development of autoimmune diseases
S Kon, T Uede
Journal of Cell Communication and Signaling 2017
Osteopontin -- a promising biomarker for cancer therapy
R Wei, JP Wong, HF Kwok
Journal of Cancer 2017
Ameliorating Effect of Osteopontin on H2O2-Induced Apoptosis of Human Oligodendrocyte Progenitor Cells
N Mazaheri, M Peymani, H Galehdari, K Ghaedi, A Ghoochani, A Kiani-Esfahani, MH Nasr-Esfahani
Cellular and Molecular Neurobiology 2017
Angiotensin 1–7, but not the thrombin-cleaved osteopontin C-terminal fragment, attenuates osteopontin-mediated macrophage-induced endothelial-cell inflammation
R Hamias, A Rudich, G Greenberg, G Szendro, T Wolak
Inflammation Research 2017
Neurotrophically Induced Mesenchymal Progenitor Cells Derived from Induced Pluripotent Stem Cells Enhance Neuritogenesis via Neurotrophin and Cytokine Production: iPSC-Derived Neurotrophic Mesenchymal Cells
RM Brick, AX Sun, RS Tuan
Stem Cells Translational Medicine 2017
Discovery of a Potential Plasma Protein Biomarker Panel for Acute-on-Chronic Liver Failure Induced by Hepatitis B Virus
N Zhou, K Wang, S Fang, X Zhao, T Huang, H Chen, F Yan, Y Tang, H Zhou, J Zhu
Frontiers in physiology 2017
Unfavorable effect of calcitriol and its low-calcemic analogs on metastasis of 4T1 mouse mammary gland cancer
A Anisiewicz, A Pawlik, B Filip-Psurska, E Turlej, S Dzimira, M Milczarek, K Gdesz, D Papiernik, J Jarosz, D Kłopotowska, A Kutner, A Mazur, J Wietrzyk
International journal of oncology 2017
Serum osteopontin: a biomarker of disease activity and predictor of relapsing course in patients with giant cell arteritis. Potential clinical usefulness in tocilizumab-treated patients
S Prieto-González, N Terrades-García, M Corbera-Bellalta, E Planas-Rigol, C Miyabe, MA Alba, A Ponce, I Tavera-Bahillo, G Murgia, G Espígol-Frigolé, J Marco-Hernández, J Hernández-Rodríguez, A García-Martínez, SH Unizony, MC Cid
RMD Open 2017
Is Osteopontin a Friend or Foe of Cell Apoptosis in Inflammatory Gastrointestinal and Liver Diseases?
Iida T, Wagatsuma K, Hirayama D, Nakase H
International journal of molecular sciences 2017
Tumour-processed osteopontin and lactadherin drive the protumorigenic reprogramming of microglia and glioma progression
A Ellert-Miklaszewska, P Wisniewski, M Kijewska, P Gajdanowicz, D Pszczolkowska, P Przanowski, M Dabrowski, M Maleszewska, B Kaminska
Oncogene 2016
The influence of calcitonin gene-related peptide on markers of bone metabolism in MG-63 osteoblast-like cells co-cultured with THP-1 macrophage-like cells under virtually osteolytic conditions
H Jablonski, H Rekasi, M Jäger
BMC musculoskeletal disorders 2016
Prognostic implication of antitumor immunity measured by the neutrophil–lymphocyte ratio and serum cytokines and angiogenic factors in gastric cancer
CY Ock, AR Nam, J Lee, JH Bang, KH Lee, SW Han, TY Kim, SA Im, TY Kim, YJ Bang, DY Oh
Gastric Cancer 2016
Osteopontin-stimulated apoptosis in cardiac myocytes involves oxidative stress and mitochondrial death pathway: role of a pro-apoptotic protein BIK
S Dalal, Q Zha, M Singh, K Singh
Molecular and Cellular Biochemistry 2016
Imatinib could be a new strategy for pulmonary hypertension caused by pulmonary tumor thrombotic microangiopathy in metastatic breast cancer
I Fukada, K Araki, K Kobayashi, T Shibayama, M Hatano, S Takahashi, T Iwase, S Ohno, Y Ito
SpringerPlus 2016
Kidney Injury Molecule-1 Is Specifically Expressed in Cystically-Transformed Proximal Tubules of the PKD/Mhm (cy/+) Rat Model of Polycystic Kidney Disease
S Gauer, A Urbschat, N Gretz, S Hoffmann, B Kränzlin, H Geiger, N Obermüller
International journal of molecular sciences 2016
Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9
Y Morisaki, M Niikura, M Watanabe, K Onishi, S Tanabe, Y Moriwaki, T Okuda, S Ohara, S Murayama, M Takao, S Uchida, K Yamanaka, H Misawa
Scientific Reports 2016
Osteopontin regulates proliferation, apoptosis, and migration of murine claudin-low mammary tumor cells
S Saleh, DE Thompson, J McConkey, P Murray, RA Moorehead
BMC Cancer 2016
The effects of immunomodulation by macrophage subsets on osteogenesis in vitro
F Loi, LA Córdova, R Zhang, J Pajarinen, T Lin, SB Goodman, Z Yao
Stem Cell Research & Therapy 2016
Osteopontin Fragments with Intact Thrombin-Sensitive Site Circulate in Cervical Cancer Patients
DT Leung, PL Lim, TH Cheung, RR Wong, SF Yim, MH Ng, FC Tam, TK Chung, YF Wong, R Samant
PloS one 2016
Novel Biomarkers to Improve the Prediction of Cardiovascular Event Risk in Type 2 Diabetes Mellitus
J der Leeuw, JW Beulens, S Dieren, CG Schalkwijk, JF Glatz, MH Hofker, WM Verschuren, JM Boer, Y der Graaf, FL Visseren, LM Peelen, YT van der Schouw
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2016
Recombinant Osteopontin Stabilizes Smooth Muscle Cell Phenotype via Integrin Receptor/Integrin-Linked Kinase/Rac-1 Pathway After Subarachnoid Hemorrhage in Rats
J Wu, Y Zhang, P Yang, B Enkhjargal, A Manaenko, J Tang, WJ Pearce, R Hartman, A Obenaus, G Chen, JH Zhang
Stroke; a journal of cerebral circulation 2016
The mdx Mutation in the 129/Sv Background Results in a Milder Phenotype: Transcriptome Comparative Analysis Searching for the Protective Factors
PC Calyjur, CF Almeida, D Ayub-Guerrieri, AF Ribeiro, SA Fernandes, R Ishiba, AL Santos, P Onofre-Oliveira, M Vainzof, M Sampaolesi
PloS one 2016
Effect of Thyrotropin on Osteopontin, Integrin αvβ3, and VCAM-1 in the Endothelium via Activation of Akt
Y Yan, F Jiang, Y Lai, H Wang, A Liu, C Wang, Y Zhang, W Teng, Z Shan
International journal of molecular sciences 2016
Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases
N Clemente, D Raineri, G Cappellano, E Boggio, F Favero, MF Soluri, C Dianzani, C Comi, U Dianzani, A Chiocchetti
Journal of Immunology Research 2016
Osteopontin improves adhesion and migration of human primary renal cortical epithelial cells during wound healing
J Wu, Z Wang
Oncology Letters 2016
Cyclic Strain and Hypertension Increase Osteopontin Expression in the Aorta.
Caesar C, Lyle AN, Joseph G, Weiss D, Alameddine FMF, Lassègue B, Griendling KK, Taylor WR
Cellular and Molecular Bioengineering 2016
Inflammatory and Repair Pathways Induced in Human Bronchoalveolar Lavage Cells with Ozone Inhalation
P Leroy, A Tham, H Wong, R Tenney, C Chen, R Stiner, JR Balmes, AC Paquet, M Arjomandi, J Fu
PloS one 2015
Current and Potential Applications of Host-Defense Peptides and Proteins in Urology
JC Lo, D Lange
BioMed Research International 2015
Dysregulated mechanisms underlying Duchenne muscular dystrophy from co-expression network preservation analysis
K Mukund, S Subramaniam
BMC Research Notes 2015
Identification of therapeutic targets for glioblastoma by network analysis
D Friedmann-Morvinski, V Bhargava, S Gupta, IM Verma, S Subramaniam
Oncogene 2015
Osteopontin mediates survival, proliferation and migration of neural stem cells through the chemokine receptor CXCR4
M Rabenstein, J Hucklenbroich, A Willuweit, A Ladwig, GR Fink, M Schroeter, KJ Langen, MA Rueger
Stem Cell Research & Therapy 2015
SVVYGLR motif of the thrombin-cleaved N-terminal osteopontin fragment enhances the synthesis of collagen type III in myocardial fibrosis
A Uchinaka, Y Hamada, S Mori, S Miyagawa, A Saito, Y Sawa, N Matsuura, H Yamamoto, N Kawaguchi
Molecular and Cellular Biochemistry 2015
OPN –Revisited
V Subramani
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH 2015
Neuroprotective Strategies after Neonatal Hypoxic Ischemic Encephalopathy
B Dixon, C Reis, W Ho, J Tang, J Zhang
International journal of molecular sciences 2015
Identification and functional study of osteosarcoma metastasis marker genes
R Shi, J Li, F Tang, Y Luo, CQ Tu
Oncology Letters 2015
Signature of cytokines and angiogenic factors (CAFs) defines a clinically distinct subgroup of gastric cancer
CY Ock, AR Nam, JH Bang, TY Kim, KH Lee, SW Han, SA Im, TY Kim, YJ Bang, DY Oh
Gastric Cancer 2015
Increased Expression of Osteopontin in the Degenerating Striatum of Rats Treated with Mitochondrial Toxin 3-Nitropropionic Acid: A Light and Electron Microscopy Study
HL Kim, MY Lee, YJ Shin, DW Song, J Park, BS Chang, JH Lee
ACTA HISTOCHEMICA ET CYTOCHEMICA 2015
Expression of Osteopontin in Oral Squamous Cell Carcinoma and its Surgical Margins-An Immunohistochemical Study
VN Subramani
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH 2015
The association between osteopontin and survival in non-small-cell lung cancer patients: a meta-analysis of 13 cohorts
YJ Lu, Y Wang, J Yang, H Liu, JR Bi, YY Chen, JY Cao, Y Liu
OncoTargets and therapy 2015
Osteopontin (OPN/SPP1) isoforms collectively enhance tumor cell invasion and dissemination in esophageal adenocarcinoma
J Lin, AL Myers, Z Wang, DJ Nancarrow, D Ferrer-Torres, A Handlogten, K Leverenz, J Bao, DG Thomas, TD Wang, MB Orringer, RM Reddy, AC Chang, DG Beer, L Lin
Oncotarget 2015
Osteopontin expression by CD103- dendritic cells drives intestinal inflammation
E Kourepini, M Aggelakopoulou, T Alissafi, N Paschalidis, DC Simoes, V Panoutsakopoulou
Proceedings of the National Academy of Sciences 2014
Eccentric muscle challenge shows osteopontin polymorphism modulation of muscle damage
WL Barfield, K Uaesoontrachoon, CS Wu, S Lin, Y Chen, PC Wang, Y Kanaan, V Bond, EP Hoffman
Human Molecular Genetics 2014
Novel roles for osteopontin and clusterin in peripheral motor and sensory axon regeneration
MC Wright, R Mi, E Connor, N Reed, A Vyas, M Alspalter, G Coppola, DH Geschwind, TM Brushart, A Höke
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes
F Kahles, HM Findeisen, D Bruemmer
Molecular Metabolism 2014
Osteopontin circulating levels correlate with renal involvement in systemic lupus erythematosus and are lower in ACE inhibitor-treated patients
M Quaglia, A Chiocchetti, T Cena, C Musetti, S Monti, N Clemente, U Dianzani, C Magnani, P Stratta
Clinical Rheumatology 2014
Osteopontin splice variant as a potential marker for metastatic disease in pancreatic adenocarcinoma: Osteopontin in pancreatic adenocarcinoma
AA Siddiqui, E Jones, D Andrade, A Shah, TE Kowalski, DE Loren, G Chipitsyna, HA Arafat
Journal of Gastroenterology and Hepatology 2014
Immunohistochemical localization and mRNA quantification of osteopontin and Tamm-Horsfall protein in canine renal tissue after potassium oxalate injection
W Mohamaden, H Wang, H Guan, X Meng, J Li
BMC veterinary research 2014
Tertiary structure prediction and identification of druggable pocket in the cancer biomarker – Osteopontin-c
S Sivakumar, SN Devaraj
Journal of Diabetes & Metabolic Disorders 2014
Osteopontin Deletion Prevents the Development of Obesity and Hepatic Steatosis via Impaired Adipose Tissue Matrix Remodeling and Reduced Inflammation and Fibrosis in Adipose Tissue and Liver in Mice
A Lancha, A Rodríguez, V Catalán, S Becerril, N Sáinz, B Ramírez, MA Burrell, J Salvador, G Frühbeck, J Gómez-Ambrosi
PloS one 2014
Cardioprotective Effects of Osteopontin-1 during Development of Murine Ischemic Cardiomyopathy
GD Duerr, B Mesenholl, JC Heinemann, M Zoerlein, P Huebener, P Schneider, A Feisst, A Ghanem, K Tiemann, D Dewald, A Welz, O Dewald
BioMed Research International 2014
Plasma levels of osteopontin and vascular endothelial growth factor in association with clinical features and parameters of tumor burden in patients with multiple myeloma
T Valković, E Babarović, K Lučin, S Štifter, M Aralica, S Pećanić, I Seili-Bekafigo, A Duletić-Načinović, D Nemet, N Jonjić
BioMed Research International 2014
Expression and purification of non-tagged recombinant mouse SPP1 in E. coli and its biological significance
S Weng, L Zhou, L Han, Y Yuan
Bioengineered 2014
Genetic association of osteopontin (OPN) and its receptor CD44 genes with susceptibility to Chinese gastric cancer patients
Y Qiu, Y Hu, ZY Zhang, L Ye, FH Xu, ME Schneider, XL Ma, YX Du, XB Zuo, FS Zhou, G Chen, XS Xie, Y Zhang, HZ Xia, JF Wu, WD Du
Journal of Cancer Research and Clinical Oncology 2014
Anti-apoptotic effects of osteopontin through the up-regulation of Mcl-1 in gastrointestinal stromal tumors
KH Hsu, HW Tsai, PW Lin, YS Hsu, PJ Lu, YS Shan
World journal of surgical oncology 2014
Osteopontin Expression in the Brain Triggers Localized Inflammation and Cell Death When Immune Cells Are Activated by Pertussis Toxin
MC Marcondes, R Ojakian, N Bortell, C Flynn, B Conti, HS Fox
Mediators of Inflammation 2014
The effect of osteopontin and osteopontin-derived peptides on preterm brain injury
AM Albertsson, X Zhang, J Leavenworth, D Bi, S Nair, L Qiao, H Hagberg, C Mallard, H Cantor, X Wang
Journal of Neuroinflammation 2014
Biomarkers in Pulmonary Arterial Hypertension
JL Rosenthal, MS Jacob
Current Heart Failure Reports 2014
Osteopontin is associated with inflammation and mortality in a mouse model of polymicrobial sepsis: Osteopontin and Sepsis
S FORTIS, RG Khadaroo, JJ Haitsma, H ZHANG
Acta Anaesthesiologica Scandinavica 2014
A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis
S Kon, Y Nakayama, N Matsumoto, K Ito, M Kanayama, C Kimura, H Kouro, D Ashitomi, T Matsuda, T Uede, WK Syn
PloS one 2014
Osteopontin Upregulates the Expression of Glucose Transporters in Osteosarcoma Cells
IS Hsieh, RS Yang, WM Fu, EC Tsilibary
PloS one 2014
Evaluating the efficacy of osteopontin expression as a prognostic marker in oral squamous cell carcinoma in the Indian subpopulation
S Routray, SM Kheur, M Kheur, N Mohanty, Y Ingale
Journal of Oral and Maxillofacial Pathology : JOMFP 2014
Molecular biomarkers in idiopathic pulmonary fibrosis
B Ley, KK Brown, HR Collard
American journal of physiology. Lung cellular and molecular physiology 2014
Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep
GA Johnson, RC Burghardt, FW Bazer
Journal of Animal Science and Biotechnology 2014
Association between Secreted Phosphoprotein-1 (SPP1) Polymorphisms and Low Bone Mineral Density in Women
JH Chen, YC Chen, CL Mao, JM Chiou, CK Tsao, KS Tsai, ME Saez
PloS one 2014
Osteopontin facilitates ultraviolet B-induced squamous cell carcinoma development.
Chang PL, Hsieh YH, Wang CC, Juliana MM, Tsuruta Y, Timares L, Elmets C, Ho KJ
Journal of Dermatological Science 2014
Osteopontin: Participation in Inflammation or Mucosal Protection in Inflammatory Bowel Diseases?
F Chen, H Liu, Q Shen, S Yuan, L Xu, X Cai, J Lian, S Chen
Digestive Diseases and Sciences 2013
Porous CaP/silk composite scaffolds to repair femur defects in an osteoporotic model
N Cheng, J Dai, X Cheng, S Li, RJ Miron, T Wu, W Chen, Y Zhang, B Shi
Journal of Materials Science: Materials in Medicine 2013
Oxygen nano-bubble water reduces calcium oxalate deposits and tubular cell injury in ethylene glycol-treated rat kidney
Y Hirose, T Yasui, K Taguchi, Y Fujii, K Niimi, S Hamamoto, A Okada, Y Kubota, N Kawai, Y Itoh, K Tozawa, S Sasaki, K Kohri
Urolithiasis 2013
Bone Sialoprotein and Osteopontin in Bone Metastasis of Osteotropic Cancers
TE Kruger, AH Miller, AK Godwin, J Wang
Critical Reviews in Oncology/Hematology 2013
Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration
YH Lee, AP Petkova, JG Granneman
Cell Metabolism 2013
The effects of MyD88 deficiency on disease phenotype in dysferlin-deficient A/J mice: role of endogenous TLR ligands
K Uaesoontrachoon, HJ Cha, B Ampong, A Sali, J Vandermeulen, B Wei, B Creeden, T Huynh, J Quinn, K Tatem, S Rayavarapu, EP Hoffman, K Nagaraju
The Journal of Pathology 2013
Acetaminophen attenuates doxorubicin-induced cardiac fibrosis via osteopontin and GATA4 regulation: reduction of oxidant levels
KJ Schunke, L Coyle, GF Merrill, DT Denhardt
Journal of Cellular Physiology 2013
Adipose tissue immunity and cancer
V Catalán, J Gómez-Ambrosi, A Rodríguez, G Frühbeck
Frontiers in physiology 2013
Osteopontin, inflammation and myogenesis: influencing regeneration, fibrosis and size of skeletal muscle
CN Pagel, DK Wijesinghe, NT Esfandouni, EJ Mackie
Journal of Cell Communication and Signaling 2013
Suppression of osteopontin functions by levocetirizine, a histamine H1 receptor antagonist, in vitro
T Komatsuzaki, I Suzaki, K Hirano, KI Kanai, K Asano, H Suzaki
BioMed Research International 2013
Defects in tendon, ligament, and enthesis in response to genetic alterations in key proteoglycans and glycoproteins: a review
SC Juneja, C Veillette
Arthritis 2013
High serum osteopontin levels are associated with low bone mineral density in postmenopausal women
EH Cho, KH Cho, HA Lee, SW Kim
Journal of Korean Medical Science 2013
Transcriptome analysis of human peripheral blood mononuclear cells exposed to Lassa virus and to the attenuated Mopeia/Lassa reassortant 29 (ML29), a vaccine candidate
JC Zapata, R Carrion, JL Patterson, O Crasta, Y Zhang, S Mani, M Jett, B Poonia, M Djavani, DM White, IS Lukashevich, MS Salvato
PLoS neglected tropical diseases 2013
Changes in mouse thymus and spleen after return from the STS-135 mission in space
DS Gridley, XW Mao, LS Stodieck, VL Ferguson, TA Bateman, M Moldovan, CE Cunningham, TA Jones, JM Slater, MJ Pecaut
PloS one 2013
Gene expression profiling as a tool to investigate the molecular machinery activated during hippocampal neurodegeneration induced by trimethyltin (TMT) administration
W Lattanzi, V Corvino, VD Maria, F Michetti, MC Geloso
International journal of molecular sciences 2013
A prospective study of bone marrow hematopoietic and mesenchymal stem cells in type 1 Gaucher disease patients
S Lecourt, E Mouly, D Freida, A Cras, R Ceccaldi, D Heraoui, C Chomienne, JP Marolleau, B Arnulf, R Porcher, C Caillaud, V Vanneaux, N Belmatoug, J Larghero
PloS one 2013
Irreversible renal damage after transient renin-angiotensin system stimulation: involvement of an AT1-receptor mediated immune response
BF Heijnen, J Nelissen, H Essen, GE Fazzi, JW Tervaert, CJ Peutz-Kootstra, JJ Mullins, CG Schalkwijk, BJ Janssen, HA Struijker-Boudier
PloS one 2013
Nasal Administration of Recombinant Osteopontin Attenuates Early Brain Injury After Subarachnoid Hemorrhage
BC Topkoru, O Altay, K Duris, PR Krafft, J Yan, JH Zhang
Stroke; a journal of cerebral circulation 2013
Matricellular Proteins: A Sticky Affair with Cancers
HC Chong, CK Tan, RL Huang, NS Tan
Journal of Oncology 2012
Extracellular Matrix and Fibroblast Communication Following Myocardial Infarction
Y Ma, GV Halade, ML Lindsey
Journal of Cardiovascular Translational Research 2012
Matricellular Proteins in Cardiac Adaptation and Disease
NG Frangogiannis
Physiological reviews 2012
Peripheral blood biomarkers in idiopathic pulmonary fibrosis
R Vij, I Noth
Translational Research 2012
Gottron's Papules Exhibit Dermal Accumulation of CD44 Variant 7 (CD44v7) and Its Binding Partner Osteopontin: A Unique Molecular Signature
JS Kim, MM Bashir, VP Werth
Journal of Investigative Dermatology 2012
Hepatocyte Growth Factor Increases Osteopontin Expression in Human Osteoblasts through PI3K, Akt, c-Src, and AP-1 Signaling Pathway
HT Chen, HK Tsou, CH Chang, CH Tang
PloS one 2012
Osteopontin Contributes to TGF-β1 Mediated Hepatic Stellate Cell Activation
X Xiao, Y Gang, Y Gu, L Zhao, J Chu, J Zhou, X Cai, H Zhang, L Xu, Y Nie, K Wu, Z Liu, D Fan
Digestive Diseases and Sciences 2012
OSTEOPONTIN, AN OXIDANT STRESS-SENSITIVE CYTOKINE, UP-REGULATES COLLAGEN-I VIA INTEGRIN αVβ3 ENGAGEMENT AND PI3K-pAkt-NFκB SIGNALING
R Urtasun, A Lopategi, J George, TM Leung, Y Lu, X Wang, X Ge, MI Fiel, N Nieto
Hepatology 2012
CCR2+CCR5+ T Cells Produce Matrix Metalloproteinase-9 and Osteopontin in the Pathogenesis of Multiple Sclerosis
W Sato, A Tomita, D Ichikawa, Y Lin, H Kishida, S Miyake, M Ogawa, T Okamoto, M Murata, Y Kuroiwa, T Aranami, T Yamamura
Journal of immunology (Baltimore, Md. : 1950) 2012
Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage
Y Yamaguchi, Z Shao, S Sharif, XY Du, T Myles, M Merchant, G Harsh, M Glantz, L Recht, J Morser, LL Leung
The Journal of biological chemistry 2012
CD44 variant isoforms are specifically expressed on peripheral blood lymphocytes from asthmatic patients
C Yang, H Liang, H Zhao, X Jiang
Experimental and therapeutic medicine 2012
Amitriptyline aggravates the fibrosis process in a rat model of infravesical obstruction
PS de Prado, MF Soares, FO Lima, N Schor, VP Teixeira
International Journal of Experimental Pathology 2012
Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema
M Shan, X Yuan, LZ Song, L Roberts, N Zarinkamar, A Seryshev, Y Zhang, S Hilsenbeck, SH Chang, C Dong, DB Corry, F Kheradmand
Science Translational Medicine 2012
NF-B and Matrix-Dependent Regulation of Osteopontin Promoter Activity in Allylamine-Activated Vascular Smooth Muscle Cells
ES Williams, E Wilson, KS Ramos
Oxidative medicine and cellular longevity 2012
Osteopontin and Other Regulators of Angiogenesis and Fibrogenesis in the Vitreous from Patients with Proliferative Vitreoretinal Disorders
AM El-Asrar, MI Nawaz, D Kangave, MM Siddiquei, K Geboes
Mediators of Inflammation 2012
Osteopontin deficiency enhances parathyroid hormone/ parathyroid hormone related peptide receptor (PPR) signaling-induced alteration in tooth formation and odontoblastic morphology
M Morishita, N Ono, K Miyai, T Nakagawa, R Hanyu, M Nagao, P Kamolratanakul, T Notomi, SR Rittling, DT Denhardt, HM Kronenberg, Y Ezura, T Hayata, T Nakamoto, M Noda
Tissue and Cell 2011
Osteopontin expression during early cerebral ischemia-reperfusion in rats: enhanced expression in the right cortex is suppressed by acetaminophen
SS Baliga, GF Merrill, ML Shinohara, DT Denhardt
PloS one 2011
Elevated circulating levels of osteopontin are associated with metastasis in advanced non-small cell lung cancer
Y Liang, H Li, B Hu, X Chen, J Miao, T Li, B You, Q Chen, Y Fu, Y Wang, S Hou
Chinese Journal of Cancer Research 2011
Hematopoietic Derived Cell Infiltration of the Intestinal Tumor Microenvironment in ApcMin/+ Mice
C Davis, R Price, G Acharya, T Baudino, T Borg, FG Berger, MM Peña
Microscopy and Microanalysis 2011
The Role of Osteopontin and Osteopontin Aptamer (OPN-R3) in Fibroblast Activity
C Hunter, J Bond, PC Kuo, MA Selim, H Levinson
Journal of Surgical Research 2011
Cadmium exposure activates the ERK signaling pathway leading to altered osteoblast gene expression and apoptotic death in Saos-2 cells
KS Arbon, CM Christensen, WA Harvey, SJ Heggland
Food and Chemical Toxicology 2011
Overlapping, Additive and Counterregulatory Effects of Type II and I Interferons on Myeloid Dendritic Cell Functions
L Frasca, R Lande
TheScientificWorldJournal 2011
Osteopontin Undergoes Polymerization in Vivo and Gains Chemotactic Activity for Neutrophils Mediated by Integrin α9β1*
N Nishimichi, H Hayashita-Kinoh, C Chen, H Matsuda, D Sheppard, Y Yokosaki
The Journal of biological chemistry 2011
Anti-Nucleocapsid Protein Immune Responses Counteract Pathogenic Effects of Rift Valley Fever Virus Infection in Mice
PJ van Vuren, CT Tiemessen, JT Paweska
PloS one 2011
Correlation of Circulating Omentin-1 with Bone Mineral Density in Multiple Sclerosis: The Crosstalk between Bone and Adipose Tissue
M Assadi, H Salimipour, S Akbarzadeh, R Nemati, SM Jafari, A Bargahi, Z Samani, M Seyedabadi, Z Sanjdideh, I Nabipour
PloS one 2011
Sympathetic control of bone mass regulated by osteopontin
M Nagao, TN Feinstein, Y Ezura, T Hayata, T Notomi, Y Saita, R Hanyu, H Hemmi, Y Izu, S Takeda, K Wang, S Rittling, T Nakamoto, K Kaneko, H Kurosawa, G Karsenty, DT Denhardt, JP Vilardaga, M Noda
Proceedings of the National Academy of Sciences 2011
Expression Profile of the Matricellular Protein Osteopontin in Primary Open-Angle Glaucoma and the Normal Human Eye
UR Chowdhury, SY Jea, DJ Oh, DJ Rhee, MP Fautsch
Investigative ophthalmology & visual science 2011
Pulmonary tumor thrombotic microangiopathy caused by lung adenocarcinoma: Case report with review of the literature
M Hotta, M Ishida, F Kojima, Y Iwai, H Okabe
Oncology Letters 2011
Osteopontin stimulates preneoplastic cellular proliferation through activation of the MAPK pathway
X Luo, MK Ruhland, E Pazolli, AC Lind, SA Stewart
Molecular cancer research : MCR 2011
Osteopontin controls endothelial cell migration in vitro and in excised human valvular tissue from patients with calcific aortic stenosis and controls
P Poggio, JB Grau, BC Field, R Sainger, WF Seefried, F Rizzolio, G Ferrari
Journal of Cellular Physiology 2011
Perinatal exposure to low-dose DE-71 increases serum thyroid hormones and gonadal osteopontin gene expression
CA Blake, GL McCoy, YY Hui, HA LaVoie
Experimental biology and medicine (Maywood, N.J.) 2011
NF- B- and AP-1-Mediated DNA Looping Regulates Osteopontin Transcription in Endotoxin-Stimulated Murine Macrophages
W Zhao, L Wang, M Zhang, P Wang, L Zhang, C Yuan, J Qi, Y Qiao, PC Kuo, C Gao
Journal of immunology (Baltimore, Md. : 1950) 2011
Molecular Mechanisms Underlying Hypothermia-Induced Neuroprotection
Y Shintani, Y Terao, H Ohta
Stroke Research and Treatment 2011
Osteopontin Reduced Hypoxia–Ischemia Neonatal Brain Injury by Suppression of Apoptosis in a Rat Pup Model
W Chen, Q Ma, H Suzuki, R Hartman, J Tang, JH Zhang
Stroke; a journal of cerebral circulation 2011
The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways
D Courter, H Cao, S Kwok, C Kong, A Banh, P Kuo, DM Bouley, C Vice, OT Brustugun, NC Denko, AC Koong, A Giaccia, QT Le
PloS one 2010
Osteopontin regulates anabolic effect in human menopausal osteoporosis with intermittent parathyroid hormone treatment
TI Chiang, IC Chang, HS Lee, H Lee, CH Huang, YW Cheng
Osteoporosis International 2010
Peroxisome Proliferator-Activated Receptor (PPAR)γ Can Inhibit Chronic Renal Allograft Damage
E Kiss, ZV Popovic, J Bedke, J Adams, M Bonrouhi, A Babelova, C Schmidt, F Edenhofer, I Zschiedrich, S Domhan, A Abdollahi, L Schäfer, N Gretz, S Porubsky, HJ Gröne
The American Journal of Pathology 2010
Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse
G Zaman, LK Saxon, A Sunters, H Hilton, P Underhill, D Williams, JS Price, LE Lanyon
Bone 2010
Mechanisms of immune-mediated liver injury
DH Adams, C Ju, SK Ramaiah, J Uetrecht, H Jaeschke
Toxicological sciences : an official journal of the Society of Toxicology 2010
Blockade of osteopontin inhibits glomerular fibrosis in a model of anti-glomerular basement membrane glomerulonephritis
C Zhou, J Wu, L Torres, JM Hicks, T Bartkowiak, K Parker, YH Lou
American Journal of Nephrology 2010
Osteopontin overproduction is associated with progression of glomerular fibrosis in a rat model of anti-glomerular basement membrane glomerulonephritis
J Merszei, J Wu, L Torres, JM Hicks, T Bartkowiak, F Tan, YH Lou
American Journal of Nephrology 2010
Role of tissue inhibitor of metalloproteinases-1 in the development of autoimmune lymphoproliferation
E Boggio, M Indelicato, E Orilieri, R Mesturini, MC Mazzarino, MF Campagnoli, U Ramenghi, U Dianzani, A Chiocchetti
Haematologica 2010
Aerosol delivery of small hairpin osteopontin blocks pulmonary metastasis of breast cancer in mice
KN Yu, A Minai-Tehrani, SH Chang, SK Hwang, SH Hong, JE Kim, JY Shin, SJ Park, JH Kim, JT Kwon, HL Jiang, B Kang, D Kim, CH Chae, KH Lee, TJ Yoon, GR Beck, MH Cho
PloS one 2010
Osteopontin impairs host defense during established gram-negative sepsis caused by Burkholderia pseudomallei (melioidosis)
GJ van der Windt, WJ Wiersinga, CW Wieland, IC Tjia, NP Day, SJ Peacock, S Florquin, T der Poll
PLoS neglected tropical diseases 2010
Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells
P Sharma, S Kumar, GC Kundu
Molecular Cancer 2010
Induction of monocyte chemoattractant protein-1 by nicotine in pancreatic ductal adenocarcinoma cells: role of osteopontin
M Lazar, J Sullivan, G Chipitsyna, T Aziz, AF Salem, Q Gong, A Witkiewicz, DT Denhardt, CJ Yeo, HA Arafat
Surgery 2010
Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation
G Murugaiyan, A Mittal, HL Weiner
Proceedings of the National Academy of Sciences 2010
Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells
W Yan, C Qian, P Zhao, J Zhang, L Shi, J Qian, N Liu, Z Fu, C Kang, P Pu, Y You
Neuro-Oncology 2010
Apc(MIN) modulation of vitamin D secosteroid growth control
H Xu, GH Posner, M Stevenson, FC Campbell
Carcinogenesis 2010
Differential expression of intracellular and secreted osteopontin isoforms by murine macrophages in response to toll-like receptor agonists
W Zhao, L Wang, L Zhang, C Yuan, PC Kuo, C Gao
The Journal of biological chemistry 2010
Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats
H Suzuki, R Ayer, T Sugawara, W Chen, T Sozen, Y Hasegawa, K Kanamaru, JH Zhang
Critical Care Medicine 2010
The differences between the localizations of MUC1, MUC5AC, MUC6 and osteopontin in quail proventriculus and gizzard may be a reflection of functional differences of stomach parts
N Liman, E Alan, GK Bayram
Journal of Anatomy 2010
Recombinant Osteopontin Attenuates Brain Injury after Intracerebral Hemorrhage in Mice
B Wu, Q Ma, H Suzuki, C Chen, W Liu, J Tang, J Zhang
Neurocritical Care 2010
1,2,3,4,6-Penta-O-galloyl-beta-D-glucose reduces renal crystallization and oxidative stress in a hyperoxaluric rat model
HJ Lee, SJ Jeong, HJ Lee, EO Lee, H Bae, JC Lieske, SH Kim
Kidney International 2010
Cleavage of Osteopontin by Matrix Metalloproteinase-12 Modulates Experimental Autoimmune Encephalomyelitis Disease in C57BL/6 Mice
AG DaSilva, L Liaw, VW Yong
The American Journal of Pathology 2010
Involvement of Osteopontin in the Matrix-Degrading and Proangiogenic Changes Mediated by Nicotine in Pancreatic Cancer Cells
M Lazar, J Sullivan, G Chipitsyna, Q Gong, CY Ng, AF Salem, T Aziz, A Witkiewicz, DT Denhardt, CJ Yeo, HA Arafat
Journal of Gastrointestinal Surgery 2010
Genes and Abdominal Aortic Aneurysm
I Hinterseher, G Tromp, H Kuivaniemi
Annals of Vascular Surgery 2010
Osteopontin and Protein Kinase C Regulate PDLIM2 Activation and STAT1 Ubiquitination in LPS-treated Murine Macrophages*
H Guo, Z Mi, DE Bowles, SD Bhattacharya, PC Kuo
The Journal of biological chemistry 2010
Differential Gene Expression in Well-healed and Poorly Healed Experimental Aneurysms after Coil Treatment1
R Kadirvel, YH Ding, D Dai, DA Lewis, DF Kallmes
Radiology 2010
The impact of the extracellular matrix on inflammation
L Sorokin
Nature Reviews Immunology 2010
Extracellular and intracellular mechanisms that mediate the metastatic activity of exogenous osteopontin
J Mandelin, EC Lin, DD Hu, SK Knowles, KA Do, X Wang, EH Sage, JW Smith, W Arap, R Pasqualini
Cancer 2009
Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease
DJ Schneider, JC Lindsay, Y Zhou, JG Molina, MR Blackburn
The FASEB Journal 2009
Antigen-specific induction of osteopontin contributes to the chronification of allergic contact dermatitis
AM Seier, AC Renkl, G Schulz, T Uebele, A Sindrilaru, S Iben, L Liaw, S Kon, T Uede, JM Weiss
The American Journal of Pathology 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Immune cells and angiogenesis
D Ribatti, E Crivellato
Journal of Cellular and Molecular Medicine 2009
Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis
SA Sharif, X Du, T Myles, JJ Song, E Price, DM Lee, SB Goodman, M Nagashima, J Morser, WH Robinson, LL Leung
Arthritis & Rheumatism 2009
beta6 Integrin subunit deficiency alleviates lung injury in a mouse model of bronchopulmonary dysplasia
A Hogmalm, D Sheppard, U Lappalainen, K Bry
American journal of respiratory cell and molecular biology 2009
Mechanisms of intermittent hypoxia induced hypertension
LV Bosc, T Resta, B Walker, NL Kanagy
Journal of Cellular and Molecular Medicine 2009
Osteopontin: A multifunctional protein at the crossroads of inflammation, atherosclerosis, and vascular calcification
HJ Cho, HJ Cho, HS Kim
Current Atherosclerosis Reports 2009
Association of plasma osteopontin levels with coronary calcification evaluated by tomographic coronary calcium scoring
M Aryan, A Kepez, E Atalar, T Hazirolan, İ Haznedaroglu, D Akata, N Ozer, S Aksoyek, K Ovunc, F Ozmen
Journal of Bone and Mineral Metabolism 2009
IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice
Q Yu, R Vazquez, EV Khojeini, C Patel, R Venkataramani, DF Larson
American journal of physiology. Heart and circulatory physiology 2009
Osteopontin: an early innate immune marker of Escherichia coli mastitis harbors genetic polymorphisms with possible links with resistance to mastitis
K Alain, NA Karrow, C Thibault, J St-Pierre, M Lessard, N Bissonnette
BMC Genomics 2009
Osteopontin is not crucial to protective immunity during murine tuberculosis
GJ van der Windt, CW Wieland, WJ Wiersinga, S Florquin, T der Poll
Immunology 2009
Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53
HJ Kim, HJ Lee, JI Jun, Y Oh, SG Choi, H Kim, CW Chung, IK Kim, IS Park, HJ Chae, HR Kim, YK Jung
Proceedings of the National Academy of Sciences 2009
Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma
J Sullivan, L Blair, A Alnajar, T Aziz, CY Ng, G Chipitsyna, Q Gong, A Witkiewicz, GF Weber, DT Denhardt, CJ Yeo, HA Arafat
Surgery 2009
Effects of corticosteroids on osteopontin expression in a murine model of allergic asthma
M Kurokawa, S Konno, S Matsukura, M Kawaguchi, K Ieki, S Suzuki, M Odaka, S Watanabe, T Homma, M Sato, H Takeuchi, T Hirose, SK Huang, M Adachi
International Archives of Allergy and Immunology 2009
Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model
S Julien, G Picco, R Sewell, AS Vercoutter-Edouart, M Tarp, D Miles, H Clausen, J Taylor-Papadimitriou, JM Burchell
British Journal of Cancer 2009
Polymeric osteopontin employs integrin alpha9beta1 as a receptor and attracts neutrophils by presenting a de novo binding site
N Nishimichi, F Higashikawa, HH Kinoh, Y Tateishi, H Matsuda, Y Yokosaki
The Journal of biological chemistry 2009
Senescent stromal-derived osteopontin promotes preneoplastic cell growth
E Pazolli, X Luo, S Brehm, K Carbery, JJ Chung, JL Prior, J Doherty, S Demehri, L Salavaggione, D Piwnica-Worms, SA Stewart
Cancer research 2009
Genomic aberrations in hepatocellular carcinoma related to osteopontin expression detected by array-CGH
JC Wu, BS Sun, N Ren, QH Ye, LX Qin
Journal of Cancer Research and Clinical Oncology 2009
Implication of expression of osteopontin and its receptor integrin ανβ3 in the placenta in the development of preeclampsia
J Xia, F Qiao, F Su, H Liu
Journal of Huazhong University of Science and Technology [Medical Sciences] 2009
Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells
G Chipitsyna, Q Gong, R Anandanadesan, A Alnajar, SK Batra, UA Wittel, DM Cullen, MP Akhter, DT Denhardt, CJ Yeo, HA Arafat
International Journal of Cancer 2009
Osteopontin negatively regulates parathyroid hormone receptor signaling in osteoblasts
N Ono, K Nakashima, SR Rittling, E Schipani, T Hayata, K Soma, DT Denhardt, HM Kronenberg, Y Ezura, M Noda
The Journal of biological chemistry 2008
Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis
G Murugaiyan, A Mittal, HL Weiner
Journal of immunology (Baltimore, Md. : 1950) 2008
Matricellular proteins produced by melanocytes and melanomas: in search for functions
M Fukunaga-Kalabis, A Santiago-Walker, M Herlyn
Cancer microenvironment : official journal of the International Cancer Microenvironment Society 2008
Osteopontin regulates development and function of invariant natural killer T cells
H Diao, K Iwabuchi, L Li, K Onoe, LV Kaer, S Kon, Y Saito, J Morimoto, DT Denhardt, S Rittling, T Uede
Proceedings of the National Academy of Sciences 2008
Osteopontin promoter polymorphism is associated with increased carotid intima-media thickness
L las Fuentes, CC Gu, SJ Mathews, JL Reagan, NP Ruthmann, AD Waggoner, CF Lai, DA Towler, VG Dávila-Román
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2008
Inhibition of matrix metalloproteinases improves left ventricular function in mice lacking osteopontin after myocardial infarction
P Krishnamurthy, JT Peterson, V Subramanian, M Singh, K Singh
Molecular and Cellular Biochemistry 2008
Molecular basis of recognition of human osteopontin by 23C3, a potential therapeutic antibody for treatment of rheumatoid arthritis
J Du, S Hou, C Zhong, Z Lai, H Yang, J Dai, D Zhang, H Wang, Y Guo, J Ding
Journal of Molecular Biology 2008
Expression and processing of small integrin-binding ligand N-linked glycoproteins in mouse odontoblastic cells
S Chen, L Chen, A Jahangiri, B Chen, Y Wu, HH Chuang, C Qin, M MacDougall
Archives of Oral Biology 2008
Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells
ML Shinohara, HJ Kim, JH Kim, VA Garcia, H Cantor
Proceedings of the National Academy of Sciences 2008
Increased expression of monocyte CD44v6 correlates with the deveopment of encephalitis in rhesus macaques infected with simian immunodeficiency virus
MC Marcondes, CM Lanigan, TH Burdo, DD Watry, HS Fox
The Journal of Infectious Diseases 2008
Regulated osteopontin expression by dendritic cells decisively affects their migratory capacity
G Schulz, AC Renkl, A Seier, L Liaw, JM Weiss
Journal of Investigative Dermatology 2008
Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring
R Mori, TJ Shaw, P Martin
Journal of Experimental Medicine 2008
Osteopontin in sepsis: any role?
M Derive, S Gibot
Intensive Care Medicine 2008
Nasal administration of osteopontin peptide mimetics confers neuroprotection in stroke
KP Doyle, T Yang, NS Lessov, TM Ciesielski, SL Stevens, RP Simon, JS King, MP Stenzel-Poore
Journal of Cerebral Blood Flow & Metabolism 2008
Osteopontin Regulates Actin Cytoskeleton and Contributes to Cell Proliferation in Primary Erythroblasts*
JA Kang, Y Zhou, TL Weis, H Liu, J Ulaszek, N Satgurunathan, L Zhou, K Besien, J Crispino, A Verma, PS Low, A Wickrema
The Journal of biological chemistry 2008
Characterization of osteopontin expression and function after status epilepticus
K Borges, M Gearing, S Rittling, ES Sorensen, R Kotloski, DT Denhardt, R Dingledine
Epilepsia 2008
Osteopontin links Obesity with Adipose Tissue Macrophage Infiltration and Insulin Resistance
Takashi Nomiyama, Diego Perez-Tilve, Daisuke Ogawa, Florence Gizard, Yue Zhao, Elizabeth B. Heywood, Karrie L. Jones, Ryuzo Kawamori, Lisa A. Cassis, Matthias H. Tschöp, Dennis Bruemmer
Journal of Clinical Investigation 2007
Anti-Inflammatory Effects of αv Integrin Antagonism in Acute Kidney Allograft Rejection
J Bedke, E Kiss, CL Behnes, ZV Popovic, M Heuser, T Stojanovic, T Sijmonsma, P Huber, S Domhan, S Muschal, A Abdollahi, N Gretz, HJ Gröne
The American Journal of Pathology 2007
The conceptus increases secreted phosphoprotein 1 gene expression in the mouse uterus during the progression of decidualization mainly due to its effects on uterine natural killer cells
JL Herington, BM Bany
Reproduction (Cambridge, England) 2007
Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy and weight loss by modulating corticosteroid production
KX Wang, Y Shi, DT Denhardt
Proceedings of the National Academy of Sciences 2007
Role of osteopontin in neutrophil function
A Koh, AP da Silva, AK Bansal, M Bansal, C Sun, H Lee, M Glogauer, J Sodek, R Zohar
Immunology 2007
Osteopontin gene expression determines spontaneous metastatic performance of orthotopic human breast cancer xenografts
M Suzuki, E Mose, C Galloy, D Tarin
The American Journal of Pathology 2007
Ultrastructural and immunocytochemical analyses of osteopontin in reactionary and reparative dentine formed after extrusion of upper rat incisors
MC Aguiar, VE Arana-Chavez
Journal of Anatomy 2007
The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse
E Pedemonte, F Benvenuto, S Casazza, G Mancardi, JR Oksenberg, A Uccelli, SE Baranzini
BMC Genomics 2007
Osteopontin promotes pathologic mineralization in articular cartilage
AK Rosenthal, CM Gohr, M Uzuki, I Masuda
Matrix biology : journal of the International Society for Matrix Biology 2007
Alteration of the Expression of CD4 Isoforms in Oral Epithelia and Saliva from Patients with Oral Lichen Planus
P Chaiyarit, K Thongprasom, S Satayut, K Dhanuthai, P Piboonratanakit, P Phothipakdee, A Subarnbhesaj, S Limlertmongkol, M Chaimusig
Journal of Clinical Immunology 2007
Osteopontin-Deficient Mice Exhibit Less Inflammation, Greater Tissue Damage, and Impaired Locomotor Recovery from Spinal Cord Injury Compared with Wild-Type Controls
M Hashimoto, D Sun, SR Rittling, DT Denhardt, W Young
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells.
Gao C, Mi Z, Guo H, Kuo PC
Neoplasia (New York, N.Y.) 2007
Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect
Michelle B. Bowie, Kristen D. McKnight, David G. Kent, Lindsay McCaffrey, Pamela A. Hoodless and Connie J. Eaves
Journal of Clinical Investigation 2006
Role of the Integrin-Binding Protein Osteopontin in Lymphatic Metastasis of Breast Cancer
AL Allan, R George, SA Vantyghem, MW Lee, NC Hodgson, CJ Engel, RL Holliday, DP Girvan, LA Scott, CO Postenka, W Al-Katib, LW Stitt, T Uede, AF Chambers, AB Tuck
The American Journal of Pathology 2006
Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice
G Kilic, J Wang, B Sosa-Pineda
Developmental dynamics : an official publication of the American Association of Anatomists 2006
Vascular calcification and osteoporosis—from clinical observation towards molecular understanding
LC Hofbauer, CC Brueck, CM Shanahan, M Schoppet, H Dobnig
Osteoporosis International 2006
Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure
O Larsson, DM Perlman, D Fan, CS Reilly, M Peterson, C Dahlgren, Z Liang, S Li, VA Polunovsky, C Wahlestedt, PB Bitterman
Nucleic Acids Research 2006
Osteopontin and cardiovascular system
H Okamoto
Molecular and Cellular Biochemistry 2006
Distinct immunohistochemical expression of osteopontin in the adult rat major salivary glands
N Obermüller, N Gassler, N Gretz, B Kränzlin, S Hoffmann, H Geiger, S Gauer
Journal Of Molecular Histology 2006
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells
ML Shinohara, L Lu, J Bu, MB Werneck, KS Kobayashi, LH Glimcher, H Cantor
Nature Immunology 2006
A distinctive alveolar macrophage activation state induced by cigarette smoking
PG Woodruff, LL Koth, YH Yang, MW Rodriguez, S Favoreto, GM Dolganov, AC Paquet, DJ Erle
American journal of respiratory and critical care medicine 2005
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size
S Stier, Y Ko, R Forkert, C Lutz, T Neuhaus, E Grünewald, T Cheng, D Dombkowski, LM Calvi, SR Rittling, DT Scadden
Journal of Experimental Medicine 2005
Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis
A Pardo, K Gibson, J Cisneros, TJ Richards, Y Yang, C Becerril, S Yousem, I Herrera, V Ruiz, M Selman, N Kaminski
PLoS Medicine 2005
Short-term treatment with anti-CD44v7 antibody, but not CD44v4, restores the gut mucosa in established chronic dextran sulphate sodium (DSS)-induced colitis in mice
S Farkas, M Hornung, C Sattler, M Anthuber, U Gunthert, H Herfarth, HJ Schlitt, EK Geissler, BM Wittig
Clinical & Experimental Immunology 2005
T-bet-dependent expression of osteopontin contributes to T cell polarization
ML Shinohara, M Jansson, ES Hwang, MB Werneck, LH Glimcher, H Cantor
Proceedings of the National Academy of Sciences 2005
A polymorphic variant inside the osteopontin gene shows association with disease course in oligoarticular juvenile idiopathic arthritis
R Marciano, F Giacopelli, MT Divizia, M Gattorno, E Felici, A Pistorio, A Martini, R Ravazzolo, P Picco
Annals of the rheumatic diseases 2005
Prognostic significance of osteopontin expression in early-stage non-small-cell lung cancer
L Boldrini, V Donati, M Dell'Omodarme, MC Prati, P Faviana, T Camacci, M Lucchi, A Mussi, M Santoro, F Basolo, G Fontanini
British Journal of Cancer 2005
Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications
B Christensen, MS Nielsen, KF Haselmann, TE Petersen, ES Sørensen
Biochemical Journal 2005
Enhanced cell surface CD44 variant (v6, v9) expression by osteopontin in breast cancer epithelial cells facilitates tumor cell migration: Novel post-transcriptional, post-translational regulation
SA Khan, AC Cook, M Kappil, U Günthert, AF Chambers, AB Tuck, DT Denhardt
Clinical & Experimental Metastasis 2005
Differentiation, Maturation, and Survival of Dendritic Cells by Osteopontin Regulation
K Kawamura, K Iyonaga, H Ichiyasu, J Nagano, M Suga, Y Sasaki
Clinical and vaccine immunology : CVI 2005
The Cytokine Osteopontin Modulates the Severity of Rotavirus Diarrhea
EE Rollo, SJ Hempson, A Bansal, E Tsao, I Habib, SR Rittling, DT Denhardt, ER Mackow, RD Shaw
Journal of virology 2005
Osteopontin expression correlates with adhesive and metastatic potential in metastasis-inducing DNA-transfected rat mammary cell lines
VE Moye, R Barraclough, C West, PS Rudland
British Journal of Cancer 2004
Chronic delayed-type hypersensitivity reaction as a means to treat alopecia areata
M Zöller, P Freyschmidt-Paul, M Vitacolonna, KJ McElwee, S Hummel, R Hoffmann
Clinical & Experimental Immunology 2004
Wound healing and inflammation genes revealed by array analysis of 'macrophageless' PU.1 null mice
L Cooper, C Johnson, F Burslem, P Martin
Genome biology 2004
Gene Expression Profiling in Neurological Disorders: Toward a Systems-Level Understanding of the Brain
SE Baranzini
NeuroMolecular Medicine 2004
Osteopontin is Strongly Expressed by Alveolar Macrophages in the Lungs of Acute Respiratory Distress Syndrome
F Takahashi, K Takahashi, K Shimizu, R Cui, N Tada, H Takahashi, S Soma, M Yoshioka, Y Fukuchi
Lung 2004
Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders.
Harmey D, Hessle L, Narisawa S, Johnson KA, Terkeltaub R, Millán JL
The American Journal of Pathology 2004
Matrix proteins
CM Gundberg
Osteoporosis International 2003
Osteopontin Deficiency Produces Osteoclast Dysfunction Due to Reduced CD44 Surface Expression
MA Chellaiah, N Kizer, R Biswas, U Alvarez, J Strauss-Schoenberger, L Rifas, SR Rittling, DT Denhardt, KA Hruska, KR Yamamoto
Molecular biology of the cell 2003
Transcriptional regulation of osteopontin and the metastatic phenotype: evidence for a Ras-activated enhancer in the human OPN promoter
David T Denhardt, Devra Mistretta, Ann F Chambers, Shuba Krishna, Joseph F Porter, Srilatha Raghuram, Susan R Rittling
Clinical & Experimental Metastasis 2003
CD44 in Cancer Progression: Adhesion, Migration and Growth Regulation
R Marhaba, M Zöller
Journal Of Molecular Histology 2003
Osteopontin and colon cancer progression
Timothy J Yeatman, Ann F Chambers
Clinical & Experimental Metastasis 2003
Expression profiling of cytokines and related genes in regenerating skeletal muscle after cardiotoxin injection: a role for osteopontin.
Hirata A, Masuda S, Tamura T, Kai K, Ojima K, Fukase A, Motoyoshi K, Kamakura K, Miyagoe-Suzuki Y, Takeda S
The American Journal of Pathology 2003
The first intron of the human osteopontin gene contains a C/EBP-beta-responsive enhancer.
Giacopelli F, Rosatto N, Divizia MT, Cusano R, Caridi G, Ravazzolo R
Gene expression 2003
Large-scale gene-expression studies and the challenge of multiple sclerosis
SE Baranzini, SL Hauser
Genome biology 2002
Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice
K Yumoto, M Ishijima, SR Rittling, K Tsuji, Y Tsuchiya, S Kon, A Nifuji, T Uede, DT Denhardt, M Noda
Proceedings of the National Academy of Sciences 2002
CD9 Is Associated with Leukemia Inhibitory Factor-mediated Maintenance of Embryonic Stem Cells
M Oka, K Tagoku, TL Russell, Y Nakano, T Hamazaki, EM Meyer, T Yokota, N Terada, J Kimble
Molecular biology of the cell 2002
Role of Osteopontin in Murine Lyme Arthritis and Host Defense against Borrelia burgdorferi
MR Potter, SR Rittling, DT Denhardt, RJ Roper, JH Weis, C Teuscher, JJ Weis
Infection and immunity 2002
Regulation of interactions between cells and extracellular matrix: a command performance on several stages
E. Helene Sage
Journal of Clinical Investigation 2001
The role of osteopontin in breast cancer: clinical and experimental studies
A B Tuck, A F Chambers
Journal of Mammary Gland Biology and Neoplasia 2001

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