Dampening the fire to prevent surgery- and chemotherapy-induced metastasis
Esra Güç and Jeffrey W. Pollard
MRC Centre for Reproductive Health, Queen’s Medical Research Institute, The University of Edinburgh, Scotland, United Kingdom.
Address correspondence to: Jeffrey W. Pollard, MRC Centre for Reproductive Health, Queen’s Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, EH16 4TJ, Edinburgh, Scotland, United Kingdom. Phone: 44.0.1312426231; Email: Jeff.Pollard@ed.ac.uk.
Find articles by Güç, E. in: JCI | PubMed | Google Scholar
MRC Centre for Reproductive Health, Queen’s Medical Research Institute, The University of Edinburgh, Scotland, United Kingdom.
Address correspondence to: Jeffrey W. Pollard, MRC Centre for Reproductive Health, Queen’s Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, EH16 4TJ, Edinburgh, Scotland, United Kingdom. Phone: 44.0.1312426231; Email: Jeff.Pollard@ed.ac.uk.
Find articles by Pollard, J. in: JCI | PubMed | Google Scholar
First published June 17, 2019 - More info
J Clin Invest. 2019;129(7):2663–2665. https://doi.org/10.1172/JCI129705.
© 2019 American Society for Clinical Investigation
In this issue of the JCI, Panigrahy et al. demonstrate that preoperative administration of the antiinflammatory drug ketorolac or specialized proresolving mediators (SPM) called resolvins increases disease-free survival rates and prevents metastasis after surgery and chemotherapy in mouse models of cancer. The antitumor response was partially mediated by tumor-specific T cell immunity and immunological memory.
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Copyright © 2019 American Society for Clinical Investigation
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