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Christy M. Gliniak, Philipp E. Scherer
Published May 13, 2019
Citation Information: J Clin Invest. 2019;129(6):2198-2200. https://doi.org/10.1172/JCI128830.
Citation Information: J Clin Invest. 2019;129(6):2198-2200. https://doi.org/10.1172/JCI128830.
Abstract
The study of beige adipose tissue (BeAT) has recently gained popularity because of its potential as a therapeutic target for the treatment of obesity and other metabolic disorders. While BeAT regulation is well understood in adults, the critical signals regulating BeAT during infant development need to be better defined. The bioactive components in breast milk have been primarily studied in the context of immunity. In this issue of the JCI, Yu and Dilbaz et al. identify how a class of breast milk–specific lipid mediators referred to as alkylglycerols (AKGs) maintain BeAT in infants and prevent the transdifferentiation of BeAT into lipid-storing white adipose tissue (WAT).
Authors
Christy M. Gliniak, Philipp E. Scherer
Citation information
Citations to this article (2)
| Title and authors | Publication | Year |
|---|---|---|
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Anti-diabetic effects of GLP1 analogs are mediated by thermogenic interleukin-6 signaling in adipocytes
Gutierrez AD, Gao Z, Hamidi V, Zhu L, Saint Andre KB, Riggs K, Ruscheinsky M, Wang H, Yu Y, Miller C III, Vasquez H, Taegtmeyer H, Kolonin MG |
Cell reports. Medicine | 2022 |
|
Brown Adipose Tissue: New Challenges for Prevention of Childhood Obesity. A Narrative Review
E Verduci, V Calcaterra, ED Profio, G Fiore, F Rey, VC Magenes, CF Todisco, S Carelli, GV Zuccotti |
Nutrients | 2021 |
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