A TWIST in the fate of human osteoblasts identifies signaling molecules involved in skull development
Ethylin Wang Jabs
Ethylin Wang Jabs
Published May 1, 2001
Citation Information: J Clin Invest. 2001;107(9):1075-1077. https://doi.org/10.1172/JCI12853.
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Figure 1

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Elements involved in the molecular pathway of sutural osteoblast differe...
Elements involved in the molecular pathway of sutural osteoblast differentiation (modified from ref. 15). Top: normal cellular differentiation and relationship of TWIST and FGFR signaling. Bottom: altered gene expression in TWIST Y103X mutant osteoblasts from a Saethre-Chotzen syndrome patient and in FGFR2 S252W mutant osteoblasts from an Apert syndrome patient. Bone sialoprotein is a mature osteoblast marker.