Taking KLF9 to “Cort” for crimes against metabolism
David R. Sweet,1,2 Liyan Fan,1,2 and Mukesh K. Jain1
1Case Cardiovascular Research Institute and University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
2Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Address correspondence to: Mukesh K. Jain, Iris & Bert L. Wolstein Research Building, 2103 Cornell Road, Cleveland, Ohio 44106, USA. Phone: 216.368.3391; Email: mxj84@case.edu.
Find articles by Sweet, D. in: JCI | PubMed | Google Scholar
1Case Cardiovascular Research Institute and University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
2Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Address correspondence to: Mukesh K. Jain, Iris & Bert L. Wolstein Research Building, 2103 Cornell Road, Cleveland, Ohio 44106, USA. Phone: 216.368.3391; Email: mxj84@case.edu.
Find articles by Fan, L. in: JCI | PubMed | Google Scholar
1Case Cardiovascular Research Institute and University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
2Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Address correspondence to: Mukesh K. Jain, Iris & Bert L. Wolstein Research Building, 2103 Cornell Road, Cleveland, Ohio 44106, USA. Phone: 216.368.3391; Email: mxj84@case.edu.
Find articles by Jain, M. in: JCI | PubMed | Google Scholar
First published April 29, 2019 - More info
J Clin Invest. 2019;129(6):2178–2180. https://doi.org/10.1172/JCI128481.
© 2019 American Society for Clinical Investigation
Glucocorticoids (GCs) are essential for proper glycemic control, but in excess, can lead to hyperglycemia and diabetes. In this issue of the JCI, Cui et al. elucidate a mechanism by which GCs regulate gluconeogenesis utilizing the transcription factor Krüppel-like factor 9 (KLF9) in physiology and disease settings. They report that KLF9 is a GC-inducible factor that ultimately increases the transcription of proliferator-activated receptor γ coactivator 1 α (PGC1α), resulting in gluconeogenesis. Given the high incidence of GC-induced diabetes, identification of this signaling axis provides, not only critical scientific insight, but also a foundation for preventative therapies for patients receiving chronic GC treatment.
- Purchase this article
- $10
- Purchasing this article will give you full access for the calendar year.
- Purchase Site Pass
- $25
- This will give you access to every article on the site for 24 hours.
- Online subscription
- $95
- Individual online subscriptions give you full online access for the calendar year.
- Individual online subscriptions ordered from September 1st on will receive access for the remainder of current year as well as for the full following year subscription term.
- Print subscription
- $830
- Individual print subscriptions give you the print journal and full online access for the year.
- JCI This Month subscription
- $125
- JCI This Month is a 16- to 20-page overview of the articles published each month
- Subscribing to JCI This Month also gives subscribers full online access for the calendar year.
- *Price outside U.S. and Canada: $225.
Copyright © 2019 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)