The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera.
P A Rufo, … , S L Alper, W I Lencer
P A Rufo, … , S L Alper, W I Lencer
Published December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3111-3120. https://doi.org/10.1172/JCI119866.
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