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H Shimano, … , M S Brown, J D Horton
Published October 15, 1997
Citation Information: J Clin Invest. 1997;100(8):2115-2124. https://doi.org/10.1172/JCI119746.
Citation Information: J Clin Invest. 1997;100(8):2115-2124. https://doi.org/10.1172/JCI119746.
Abstract
Research Article
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H Shimano, I Shimomura, R E Hammer, J Herz, J L Goldstein, M S Brown, J D Horton
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Citations to this article (479)
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The Liver in Systemic Diseases | 2016 |
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Sweeteners
JM Merillon, KG Ramawat |
Sweeteners | 2016 |
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Chronic hyperprolactinemia evoked by disruption of lactotrope dopamine D2 receptors impacts on liver and adipocyte genes related to glucose and insulin balance
GM Luque, F Lopez-Vicchi, AM Ornstein, B Brie, CD Winne, E Fiore, MI Perez-Millan, G Mazzolini, M Rubinstein, D Becu-Villalobos |
American journal of physiology. Endocrinology and metabolism | 2016 |
|
miR-29a Promotes Lipid Droplet and Triglyceride Formation in HCV Infection by Inducing Expression of SREBP-1c and CAV1.
Mahdy MM, El-Ekiaby NM, Hashish RM, Salah RA, Hanafi RS, Azzazy HM, Abdelaziz AI |
Journal of Clinical and Translational Hepatology | 2016 |
|
Protective effect of oligomeric proanthocyanidins against alcohol-induced liver steatosis and injury in mice
Z Wang, B Su, S Fan, H Fei, W Zhao |
Biochemical and Biophysical Research Communications | 2015 |
|
Ergostatrien-3β-ol from Antrodia camphorata Inhibits Diabetes and Hyperlipidemia in High-Fat-Diet Treated Mice via Regulation of Hepatic Related Genes, Glucose Transporter 4, and AMP-Activated Protein Kinase Phosphorylation
YH Kuo, CH Lin, CC Shih |
Journal of Agricultural and Food Chemistry | 2015 |
|
Antidiabetic and Antihyperlipidemic Properties of a Triterpenoid Compound, Dehydroeburicoic Acid, from Antrodia camphorata in Vitro and in Streptozotocin-Induced Mice
YH Kuo, CH Lin, CC Shih |
Journal of Agricultural and Food Chemistry | 2015 |
|
De novo lipogenesis in metabolic homeostasis: More friend than foe?
G Solinas, J Borén, AG Dulloo |
Molecular Metabolism | 2015 |
|
Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP
SJ Ricoult, JL Yecies, I Ben-Sahra, BD Manning |
Oncogene | 2015 |
|
Revisiting Human Cholesterol Synthesis and Absorption: The Reciprocity Paradigm and its Key Regulators
PA Alphonse, PJ Jones |
Lipids | 2015 |
|
SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression
L Vergnes, RG Chin, TA Vallim, LG Fong, TF Osborne, SG Young, K Reue |
Journal of lipid research | 2015 |
|
Transcriptional regulation of hepatic lipogenesis
Y Wang, J Viscarra, SJ Kim, HS Sul |
Nature Reviews Molecular Cell Biology | 2015 |
|
Selective inhibition of liver X receptor α-mediated lipogenesis in primary hepatocytes by licochalcone A
GS Oh, GG Lee, J Yoon, WK Oh, SW Kim |
Chinese medicine | 2015 |
|
d-Xylose suppresses adipogenesis and regulates lipid metabolism genes in high-fat diet–induced obese mice
E Lim, JY Lim, JH Shin, PR Seok, S Jung, SH Yoo, Y Kim |
Nutrition Research | 2015 |
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The association of APOC4 polymorphisms with premature coronary artery disease in a Chinese Han population
S Xu, J Cheng, N Li, Y Chen, M Cai, S Tang, H Huang, B Zhang, J Cen, X Yang, C Chen, X Liu, X Xiong |
Lipids in Health and Disease | 2015 |
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Black ginseng extract ameliorates hypercholesterolemia in rats
E Saba, BR Jeon, DH Jeong, K Lee, YK Goo, SH Kim, CK Sung, SS Roh, SD Kim, HK Kim, MH Rhee |
Journal of Ginseng Research | 2015 |
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Regulation of SREBPs by Sphingomyelin in Adipocytes via a Caveolin and Ras-ERK-MAPK-CREB Signaling Pathway
N Makdissy, K Haddad, C Mouawad, I Popa, M Younsi, P Valet, L Brunaud, O Ziegler, D Quilliot, D Delmas |
PloS one | 2015 |
|
Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation
K Inoue, Y Imai |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2015 |
|
Biocompatible polymeric nanocomplexes as an intracellular stimuli-sensitive prodrug for type-2 diabetes combination therapy
FZ Wang, ZS Xie, L Xing, BF Zhang, JL Zhang, PF Cui, JB Qiao, K Shi, CS Cho, MH Cho, X Xu, P Li, HL Jiang |
Biomaterials | 2015 |
|
Hepatic De Novo Lipogenesis and Regulation of Metabolism
JM Ntambi |
Hepatic De Novo Lipogenesis and Regulation of Metabolism | 2015 |
|
PAS Kinase Drives Lipogenesis through SREBP-1 Maturation
X Wu, D Romero, WI Swiatek, I Dorweiler, CK Kikani, H Sabic, BS Zweifel, J McKearn, JT Blitzer, GA Nickols, J Rutter |
Cell Reports | 2014 |
|
mTOR signaling in tumorigenesis
K Xu, P Liu, W Wei |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2014 |
|
Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance
YA Moon, CR Ochoa, MA Mitsche, RE Hammer, JD Horton |
Journal of lipid research | 2014 |
|
Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling
X Li, YT Chen, P Hu, WC Huang |
Molecular cancer therapeutics | 2014 |
|
Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins
J Miao, JT Haas, P Manthena, Y Wang, E Zhao, B Vaitheesvaran, IJ Kurland, SB Biddinger |
Journal of lipid research | 2014 |
|
MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease
Xiao Chen Wang, Xiao Rong Zhan, Xin Yu Li, Jun Jie Yu, Xiao Min Liu |
World Journal of Gastroenterology | 2014 |
|
Overactivation of Intestinal SREBP2 in Mice Increases Serum Cholesterol
K Ma, P Malhotra, V Soni, O Hedroug, F Annaba, A Dudeja, L Shen, JR Turner, EA Khramtsova, S Saksena, PK Dudeja, RK Gill, WA Alrefai, JM Lobaccaro |
PloS one | 2014 |
|
What We Talk About When We Talk About Fat
ED Rosen, BM Spiegelman |
Cell | 2014 |
|
Inhibition of SREBP Transcriptional Activity by a Boron-Containing Compound Improves Lipid Homeostasis in Diet-Induced Obesity
X Zhao, Xiaoli, H Zong, A Abdulla, ES Yang, Q Wang, JY Ji, JE Pessin, BC Das, F Yang |
Diabetes | 2014 |
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An acetate switch regulates stress erythropoiesis
M Xu, JS Nagati, J Xie, J Li, H Walters, YA Moon, RD Gerard, CL Huang, SA Comerford, RE Hammer, JD Horton, R Chen, JA Garcia |
Nature Medicine | 2014 |
|
Activating transcription factor 6 is necessary and sufficient for alcoholic Fatty liver disease in zebrafish
DL Howarth, C Lindtner, AM Vacaru, R Sachidanandam, O Tsedensodnom, T Vasilkova, C Buettner, KC Sadler |
PLoS genetics | 2014 |
|
Combination of honokiol and magnolol inhibits hepatic steatosis through AMPK-SREBP-1 c pathway
JH Lee, JY Jung, EJ Jang, KH Jegal, SY Moon, SK Ku, SH Kang, IJ Cho, SJ Park, JR Lee, RJ Zhao, SC Kim, YW Kim |
Experimental biology and medicine (Maywood, N.J.) | 2014 |
|
ChREBP, a glucose-responsive transcriptional factor, enhances glucose metabolism to support biosynthesis in human cytomegalovirus-infected cells
Y Yu, TG Maguire, JC Alwine |
Proceedings of the National Academy of Sciences | 2014 |
|
Acetate Dependence of Tumors
SA Comerford, Z Huang, X Du, Y Wang, L Cai, AK Witkiewicz, H Walters, MN Tantawy, A Fu, HC Manning, JD Horton, RE Hammer, SL McKnight, BP Tu |
Cell | 2014 |
|
HMGCR is necessary for the tumorigenecity of esophageal squamous cell carcinoma and is regulated by Myc
C Zhong, L Fan, F Yao, J Shi, W Fang, H Zhao |
Tumor Biology | 2014 |
|
Effect of a Synthetic Liver X Receptor Agonist TO901317 on Cholesterol Concentration in Goose Primary Hepatocytes
F He, C Han, D Liu, H Wan, J Wang, H Liu, L Li, H Xu, H He |
Italian Journal of Animal Science | 2014 |
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Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish
DL Howarth, C Lindtner, AM Vacaru, R Sachidanandam, O Tsedensodnom, T Vasilkova, C Buettner, KC Sadler, MC Mullins |
PLoS genetics | 2014 |
|
MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease
XC Wang, XR Zhan, XY Li, JJ Yu, XM Liu |
World journal of gastroenterology : WJG | 2014 |
|
HMGCR is necessary for the tumorigenecity of esophageal squamous cell carcinoma and is regulated by Myc.
Zhong C, Fan L, Yao F, Shi J, Fang W, Zhao H |
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | 2014 |
|
Insulin signalling mechanisms for triacylglycerol storage
MP Czech, M Tencerova, DJ Pedersen, M Aouadi |
Diabetologia | 2013 |
|
MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice
T Horie, T Nishino, O Baba, Y Kuwabara, T Nakao, M Nishiga, S Usami, M Izuhara, N Sowa, N Yahagi, H Shimano, S Matsumura, K Inoue, H Marusawa, T Nakamura, K Hasegawa, N Kume, M Yokode, T Kita, T Kimura, K Ono |
Nature Communications | 2013 |
|
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
Y Kidani, H Elsaesser, MB Hock, L Vergnes, KJ Williams, JP Argus, BN Marbois, E Komisopoulou, EB Wilson, TF Osborne, TG Graeber, K Reue, DG Brooks, SJ Bensinger |
Nature Immunology | 2013 |
|
cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1
K Cai, MB Sewer |
Journal of lipid research | 2013 |
|
Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling
Laura V Danai, Adilson Guilherme, Kalyani V Guntur, Juerg Straubhaar, Sarah M Nicoloro, Michael P Czech |
2013 | |
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Insig Proteins Mediate Feedback Inhibition of Cholesterol Synthesis in the Intestine
MR McFarlane, G Liang, LJ Engelking |
The Journal of biological chemistry | 2013 |
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PKR-Like Endoplasmic Reticulum Kinase Is Necessary for Lipogenic Activation during HCMV Infection
Y Yu, FJ Pierciey, TG Maguire, JC Alwine, B Damania |
PLoS pathogens | 2013 |
|
Role of immunodeficient animal models in the development of fructose induced NAFLD
J Bhattacharjee, JM Kumar, S Arindkar, B Das, U Pramod, RC Juyal, SS Majumdar, P Nagarajan |
The Journal of Nutritional Biochemistry | 2013 |
|
Sphingolipids and atherosclerosis
T Hornemann, TS Worgall |
Atherosclerosis | 2013 |
|
MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer cells
X Li, YT Chen, S Josson, NK Mukhopadhyay, J Kim, MR Freeman, WC Huang |
PloS one | 2013 |
|
Chinese medicine formula lingguizhugan decoction improves Beta-oxidation and metabolism of Fatty Acid in high-fat-diet-induced rat model of Fatty liver disease
T Liu, LL Yang, L Zou, DF Li, HZ Wen, PY Zheng, LJ Xing, HY Song, XD Tang, G Ji |
Evidence-Based Complementary and Alternative Medicine | 2013 |
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Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake
M Yang, W Liu, C Pellicane, C Sahyoun, BK Joseph, C Gallo-Ebert, M Donigan, D Pandya, C Giordano, A Bata, JT Nickels |
Journal of lipid research | 2013 |
|
Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling[S]
Laura V. Danai, Adilson Guilherme, Kalyani V. Guntur, Juerg Straubhaar, Sarah M. Nicoloro, Michael P. Czech |
2013 | |
|
Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling
LV Danai, A Guilherme, KV Guntur, J Straubhaar, SM Nicoloro, MP Czech |
Journal of lipid research | 2013 |
|
MicroRNA-185 and 342 Inhibit Tumorigenicity and Induce Apoptosis through Blockade of the SREBP Metabolic Pathway in Prostate Cancer Cells
X Li, YT Chen, S Josson, NK Mukhopadhyay, J Kim, MR Freeman, WC Huang, M Campbell |
PloS one | 2013 |
|
Physiologie et physiopathologie du tissu adipeux
JP Bastard, B Fève |
2013 | |
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A Duplication CNV That Conveys Traits Reciprocal to Metabolic Syndrome and Protects against Diet-Induced Obesity in Mice and Men
M Lacaria, P Saha, L Potocki, W Bi, J Yan, S Girirajan, B Burns, S Elsea, K Walz, L Chan, JR Lupski, W Gu |
PLoS genetics | 2012 |
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A Common Thread Connects Antidiabetic Effects of Multiple Nuclear Receptors
DD Moore |
Cell Metabolism | 2012 |
|
Preventing Phosphorylation of Sterol Regulatory Element-Binding Protein 1a by MAP-Kinases Protects Mice from Fatty Liver and Visceral Obesity
J Kotzka, B Knebel, J Haas, L Kremer, S Jacob, S Hartwig, U Nitzgen, D Muller-Wieland |
PloS one | 2012 |
|
Effects of sterol regulatory element-binding protein (SREBP) in chickens
FA Khesht, A Hassanabadi |
Lipids in Health and Disease | 2012 |
|
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
MA Herman, OD Peroni, J Villoria, MR Schön, NA Abumrad, M Blüher, S Klein, BB Kahn |
Nature | 2012 |
|
Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes
LJ Engelking, MR McFarlane, CK Li, G Liang |
Journal of lipid research | 2012 |
|
The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals
YA Moon, G Liang, X Xie, M Frank-Kamenetsky, K Fitzgerald, V Koteliansky, MS Brown, JL Goldstein, JD Horton |
Cell Metabolism | 2012 |
|
Adipogenesis
K Sarjeant, JM Stephens |
Cold Spring Harbor perspectives in biology | 2012 |
|
JD induced pluripotent stem cell-derived hepatocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia
MA Cayo, J Cai, A DeLaForest, FK Noto, M Nagaoka, BS Clark, RF Collery, K Si-Tayeb, SA Duncan |
Hepatology | 2012 |
|
Ablation of gp78 in Liver Improves Hyperlipidemia and Insulin Resistance by Inhibiting SREBP to Decrease Lipid Biosynthesis
TF Liu, JJ Tang, PS Li, Y Shen, JG Li, HH Miao, BL Li, BL Song |
Cell Metabolism | 2012 |
|
Regulation of endothelial lipase and systemic HDL cholesterol levels by SREBPs and VEGF-A
AM Kivelä, MH Dijkstra, SE Heinonen, E Gurzeler, S Jauhiainen, AL Levonen, S Ylä-Herttuala |
Atherosclerosis | 2012 |
|
Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes[S]
LJ Engelking, MR McFarlane, CK Li, G Liang |
Journal of lipid research | 2012 |
|
Preventing Phosphorylation of Sterol Regulatory Element-Binding Protein 1a by MAP-Kinases Protects Mice from Fatty Liver and Visceral Obesity
J Kotzka, B Knebel, J Haas, L Kremer, S Jacob, S Hartwig, U Nitzgen, D MullerWieland, S Blanc |
PloS one | 2012 |
|
High-fat diet ameliorates neurological deficits caused by defective astrocyte lipid metabolism
N Camargo, JF Brouwers, M Loos, DH Gutmann, AB Smit, MH Verheijen |
The FASEB Journal | 2012 |
|
Physiology and Physiopathology of Adipose Tissue
JP Bastard, B Fève |
2012 | |
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The A2b Adenosine Receptor Regulates Hyperlipidemia and Atherosclerosis
M Koupenova, H Johnston-Cox, A Vezeridis, H Gavras, D Yang, V Zannis, K Ravid |
Circulation | 2011 |
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Hepatic ABCA1 and VLDL triglyceride production
M Liu, S Chung, GS Shelness, JS Parks |
Biochimica et Biophysica Acta | 2011 |
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SREBPs: metabolic integrators in physiology and metabolism
TI Jeon, TF Osborne |
Trends in Endocrinology and Metabolism | 2011 |
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Early Growth Response 1 (Egr1) Regulates Cholesterol Biosynthetic Gene Expression*
NG Gokey, C Lopez-Anido, AL Gillian-Daniel, J Svaren |
The Journal of biological chemistry | 2011 |
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Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice
S Kumadaki, T Karasawa, T Matsuzaka, M Ema, Y Nakagawa, M Nakakuki, R Saito, N Yahagi, H Iwasaki, H Sone, K Takekoshi, S Yatoh, K Kobayashi, A Takahashi, H Suzuki, S Takahashi, N Yamada, H Shimano |
The Journal of biological chemistry | 2011 |
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Regulation of cholesterol and fatty acid synthesis
J Ye, RA DeBose-Boyd |
Cold Spring Harbor perspectives in biology | 2011 |
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Genetics and molecular biology
J Pétremand, C Widmann |
Current Opinion in Lipidology | 2011 |
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The Enzymes
EJ Chenette, CJ Der |
Protein Prenylation PART A | 2011 |
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Insulin signaling to hepatic lipid metabolism in health and disease
KF Leavens, MJ Birnbaum |
Critical Reviews in Biochemistry and Molecular Biology | 2011 |
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Dietary Saury Oil Reduces Hyperglycemia and Hyperlipidemia in Diabetic KKAy Mice and in Diet-Induced Obese C57BL/6J Mice by Altering Gene Expression
ZH Yang, H Miyahara, S Takemura, A Hatanaka |
Lipids | 2011 |
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Early Growth Response 1 (Egr1) Regulates Cholesterol Biosynthetic Gene Expression
NG Gokey, C Lopez-Anido, AL Gillian-Daniel, J Svaren |
The Journal of biological chemistry | 2011 |
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Dietary saury oil reduces hyperglycemia and hyperlipidemia in diabetic KKAy mice and in diet-induced obese C57BL/6J mice by altering gene expression.
Yang ZH, Miyahara H, Takemura S, Hatanaka A |
Lipids | 2011 |
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MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo
T Horie, K Ono, M Horiguchi, H Nishi, T Nakamura, K Nagao, M Kinoshita, Y Kuwabara, H Marusawa, Y Iwanaga, K Hasegawa, M Yokode, T Kimura, T Kita |
Proceedings of the National Academy of Sciences | 2010 |
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Activation of Sterol Regulatory Element Binding Proteins in the Absence of Scap in Drosophila melanogaster
KA Matthews, C Ozdemir, RB Rawson |
Genetics | 2010 |
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Transcriptional factors that promote formation of white adipose tissue
UA White, JM Stephens |
Molecular and Cellular Endocrinology | 2010 |
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Chinese prescription Kangen-karyu prevents dyslipidaemia and oxidative stress in mouse model of type 2 diabetes
JS Noh, CH Park, HY Kim, Q Zhao, N Yamabe, K Matsumoto, T Yokozawa |
Journal of Pharmacy and Pharmacology | 2010 |
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Central players in inherited lipodystrophies
EH Jeninga, E Kalkhoven |
Trends in Endocrinology & Metabolism | 2010 |
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Insulin resistance at the crossroads of metabolic syndrome: Systemic analysis using microarrays
E Kim |
Biotechnology Journal | 2010 |
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Vitamins & Hormones
KJ Hare, FK Knop |
Vitamins & Hormones | 2010 |
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Adipose Tissue in Health and Disease: LEFF:ADIPOSE TISSUE O-BK
LA Cassis, SB Police |
Adipose Tissue in Health and Disease: LEFF:ADIPOSE TISSUE O-BK | 2010 |
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Androgen Receptor Survival Signaling Is Blocked by Anti-β2-microglobulin Monoclonal Antibody via a MAPK/Lipogenic Pathway in Human Prostate Cancer Cells
WC Huang, HE Zhau, LW Chung |
The Journal of biological chemistry | 2010 |
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Prenatal Dexamethasone Programs Expression of Genes in Liver and Adipose Tissue and Increased Hepatic Lipid Accumulation But Not Obesity on a High-Fat Diet
AJ Drake, PJ Raubenheimer, D Kerrigan, KJ McInnes, JR Seckl, BR Walker |
Endocrinology | 2010 |
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Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2
SS Im, LE Hammond, L Yousef, C Nugas-Selby, DJ Shin, YK Seo, LG Fong, SG Young, TF Osborne |
Molecular and cellular biology | 2009 |
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Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts
V Besnard, SE Wert, MT Stahlman, AD Postle, Y Xu, M Ikegami, JA Whitsett |
The Journal of biological chemistry | 2009 |
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Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation
YS Yoon, WY Seo, MW Lee, ST Kim, SH Koo |
The Journal of biological chemistry | 2009 |
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Dissecting the role of insulin resistance in the metabolic syndrome
JT Haas, SB Biddinger |
Current Opinion in Lipidology | 2009 |
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Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Δ24-reductase-deficient cell line
S Rodríguez-Acebes, P la Cueva, C Fernández-Hernando, AJ Ferruelo, MA Lasunción, RB Rawson, J Martínez-Botas, D Gómez-Coronado |
Biochemical Journal | 2009 |
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Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
YA Moon, RE Hammer, JD Horton |
Journal of lipid research | 2009 |
|
Transcriptional targets in adipocyte biology
E Rosen, J Eguchi, Z Xu |
Expert Opinion on Therapeutic Targets | 2009 |
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SREBPs: physiology and pathophysiology of the SREBP family
H Shimano |
FEBS Journal | 2009 |
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C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis
VA Payne, WS Au, CE Lowe, SM Rahman, JE Friedman, S O'Rahilly, JJ Rochford |
Biochemical Journal | 2009 |
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Magnolia officinalis Reverses Alcoholic Fatty Liver by Inhibiting the Maturation of Sterol Regulatory Element–Binding Protein-1c
HQ Yin, YT Je, YC Kim, YK Shin, SH Sung, KY Lee, GS Jeong, YC Kim, BH Lee |
Journal of Pharmacological Sciences | 2009 |
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Coordination of Lipid Metabolism in Membrane Biogenesis
A Nohturfft, SC Zhang |
Annual Review of Cell and Developmental Biology | 2009 |
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Anti-aging and diet
Y Fujiwara |
Drug Delivery System | 2009 |
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Salt-inducible Kinase Regulates Hepatic Lipogenesis by Controlling SREBP-1c Phosphorylation
YS Yoon, WY Seo, MW Lee, ST Kim, SH Koo |
The Journal of biological chemistry | 2009 |
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Lipids in Health and Disease
PJ Quinn, X Wang |
Lipids in Health and Disease | 2008 |
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Lipids in Health and Disease
PJ Quinn, X Wang |
Lipids in Health and Disease | 2008 |
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Lipids in Health and Disease
PJ Quinn, X Wang |
Lipids in Health and Disease | 2008 |
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Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells and Experimental Animals
JL Hawkins, MD Robbins, LC Warren, D Xia, SF Petras, JJ Valentine, AH Varghese, IK Wang, TA Subashi, LD Shelly, BA Hay, KT Landschulz, KF Geoghegan, HJ Harwood |
The Journal of pharmacology and experimental therapeutics | 2008 |
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Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets
T Kato, H Shimano, T Yamamoto, M Ishikawa, S Kumadaki, T Matsuzaka, Y Nakagawa, N Yahagi, M Nakakuki, AH Hasty, Y Takeuchi, K Kobayashi, A Takahashi, S Yatoh, H Suzuki, H Sone, N Yamada |
Diabetes | 2008 |
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Modern Nutrition
K LaPoint, M McIntosh |
Handbook of Nutrition in the Aged, Fourth Edition | 2008 |
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Macronutrients and obesity: views, news and reviews
L Madsen, B Liaset, K Kristiansen |
Future Lipidology | 2008 |
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Bioactive lipids in metabolic syndrome
K Nagao, T Yanagita |
Progress in Lipid Research | 2008 |
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Hzf regulates adipogenesis through translational control of C/EBPalpha
H Kawagishi, T Wakoh, H Uno, M Maruyama, A Moriya, S Morikawa, H Okano, CJ Sherr, M Takagi, M Sugimoto |
The EMBO Journal | 2008 |
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High-carbohydrate diets affect the size and composition of plasma lipoproteins in hamsters (Mesocricetus auratus)
L Wang, J Yu, RL Walzem |
Comparative medicine | 2008 |
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Deletion of Scap in Alveolar Type II Cells Influences Lung Lipid Homeostasis and Identifies a Compensatory Role for Pulmonary Lipofibroblasts
V Besnard, SE Wert, MT Stahlman, AD Postle, Y Xu, M Ikegami, JA Whitsett |
The Journal of biological chemistry | 2008 |
|
Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
YA Moon, RE Hammer, JD Horton |
Journal of lipid research | 2008 |
|
SREBP1 is required for the induction by glucose of pancreatic β-cell genes involved in glucose sensing
F Diraison, MA Ravier, SK Richards, RM Smith, H Shimano, GA Rutter |
Journal of lipid research | 2008 |
|
Dietary polyunsaturated fatty acids (C18:2 ω6 and C18:3 ω3) do not suppress hepatic lipogenesis
W Sealls, M Gonzalez, MJ Brosnan, PN Black, CC DiRusso |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2008 |
|
Preservation of VLDL remnant clearance attenuates the phenotype of autosomal recessive hypercholesterolemia
Christopher Jones, Rita Garuti1, Peter Michaely, Wei-Ping Li, Nobuyo Maeda, Jonathan C. Cohen, Joachim Herz, and Helen H. Hobbs |
Journal of Clinical Investigation | 2007 |
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Parasympathetic Response of the Heart is controlled by SREBP
Ho-Jin Park, Serban P. Georgescu, Chuang Du, Christopher Madias, Mark J. Aronovitz, C. Michael Welzig, Bo Wang, Ulrike Begley, Yali Zhang, Robert O. Blaustein, Richard D. Patten, Richard H. Karas, Herbert H. Van Tol, Timothy F. Osborne, Hitoshi Shimano, Ronglih Liao, Mark Link and Jonas B. Galper |
Journal of Clinical Investigation | 2007 |
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Handbook of Experimental Pharmacology
HH Bock, J Herz, P May |
Handbook of experimental pharmacology | 2007 |
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A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G(1) cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors
M Nakakuki, H Shimano, N Inoue, M Tamura, T Matsuzaka, Y Nakagawa, N Yahagi, H Toyoshima, R Sato, N Yamada |
The FEBS journal | 2007 |
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Involvement of glomerular SREBP-1c in diabetic nephropathy
N Ishigaki, T Yamamoto, Y Shimizu, K Kobayashi, S Yatoh, H Sone, A Takahashi, H Suzuki, K Yamagata, N Yamada, H Shimano |
Biochemical and Biophysical Research Communications | 2007 |
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Lessons from “Lower” Organisms: What Worms, Flies, and Zebrafish Can Teach Us about Human Energy Metabolism
A Schlegel, DY Stainier, ME MacDonald |
PLoS genetics | 2007 |
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Characterisation of insulin-resistant phenotype of cultured rat primary adipose cells
CC Xiang, YJ Wu, L Ma, L Ding, I Lisinski, MJ Brownstein, SW Cushman, X Chen |
Diabetologia | 2007 |
|
Critical role of PA28gamma in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis
K Moriishi, R Mochizuki, K Moriya, H Miyamoto, Y Mori, T Abe, S Murata, K Tanaka, T Miyamura, T Suzuki, K Koike, Y Matsuura |
Proceedings of the National Academy of Sciences | 2007 |
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Site-1 protease is essential for endochondral bone formation in mice
D Patra, X Xing, S Davies, J Bryan, C Franz, EB Hunziker, LJ Sandell |
The Journal of Cell Biology | 2007 |
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Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike
J Yan, W Bi, JR Lupski |
The American Journal of Human Genetics | 2007 |
|
Effects of In Ovo Administration of DHEA on Lipid Metabolism and Hepatic Lipogenetic Genes Expression in Broiler Chickens During Embryonic Development
S Zhao, H Ma, S Zou, W Chen |
Lipids | 2007 |
|
Pathogenesis of hepatitis C virus
K MORIISHI, Y MATSUURA |
Uirusu | 2007 |
|
Transcriptional downregulation of sterol metabolism genes in murine liver exposed to acute hypobaric hypoxia
KS Dolt, J Karar, MK Mishra, J Salim, R Kumar, SK Grover, MA Pasha |
Biochemical and Biophysical Research Communications | 2007 |
|
The Role of Dietary Protein on Lipotoxicity
N Torres, AR Tovar |
Nutrition Reviews | 2007 |
|
Obesity: Genomics and Postgenomics
A Xu, A Butler, G Barsh |
Obesity: Genomics and Postgenomics | 2007 |
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Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression
V Besnard, Y Xu, JA Whitsett |
American journal of physiology. Lung cellular and molecular physiology | 2007 |
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Genistein Downregulates SREBP-1 Regulated Gene Expression by Inhibiting Site-1 Protease Expression in HepG2 Cells
ES Shin, HH Lee, SY Cho, HW Park, SJ Lee, TR Lee |
The Journal of nutrition | 2007 |
|
Effects of in ovo administration of DHEA on lipid metabolism and hepatic lipogenetic genes expression in broiler chickens during embryonic development.
Zhao S, Ma H, Zou S, Chen W |
Lipids | 2007 |
|
An Investigation of the Reciprocal Relationship of Cholesterol Absorption and Synthesis in Humans
Sylvia Santosa, Krista A Varady, Suhad AbuMweis, Peter JH Jones |
Life Sciences | 2006 |
|
Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation
K Chu, M Miyazaki, WC Man, JM Ntambi |
Molecular and cellular biology | 2006 |
|
Adipocyte differentiation from the inside out
ED Rosen, OA MacDougald |
Nature Reviews Molecular Cell Biology | 2006 |
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Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice
T Kato, H Shimano, T Yamamoto, T Yokoo, Y Endo, M Ishikawa, T Matsuzaka, Y Nakagawa, S Kumadaki, N Yahagi, A Takahashi, H Sone, H Suzuki, H Toyoshima, AH Hasty, S Takahashi, H Gomi, T Izumi, N Yamada |
Cell Metabolism | 2006 |
|
Nelfinavir induces liposarcoma apoptosis and cell cycle arrest by upregulating sterol regulatory element binding protein-1
WA Chow, S Guo, F Valdes-Albini |
Anti-Cancer Drugs | 2006 |
|
Nelfinavir induces liposarcoma apoptosis and cell cycle arrest by upregulating sterol regulatory element binding protein-1:
WA Chow, S Guo, F Valdes-Albini |
Anti-Cancer Drugs | 2006 |
|
Regulation of Human Cytochrome P450 4F2 Expression by Sterol Regulatory Element-binding Protein and Lovastatin
MH Hsu, Ü Savas, KJ Griffin, EF Johnson |
The Journal of biological chemistry | 2006 |
|
Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker diabetic fatty rat islets: a functional and gene profiling analysis
LE Parton, PJ McMillen, Y Shen, E Docherty, E Sharpe, F Diraison, CP Briscoe, GA Rutter |
American journal of physiology. Endocrinology and metabolism | 2006 |
|
22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes
ET Kase, B Andersen, HI Nebb, AC Rustan, GH Thoresen |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2006 |
|
Schoenheimer Effect explained - Feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
Luke J. Engelking, Guosheng Liang, Robert E. Hammer, Kiyosumi Takaishi, Hiroshi Kuriyama, Bret M. Evers, Wei-Ping Li, Jay D. Horton, Joseph L. Goldstein, and Michael S. Brown |
Journal of Clinical Investigation | 2005 |
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Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes
K Maeda, H Cao, K Kono, CZ Gorgun, M Furuhashi, KT Uysal, Q Cao, G Atsumi, H Malone, B Krishnan, Y Minokoshi, BB Kahn, RA Parker, GS Hotamisligil |
Cell Metabolism | 2005 |
|
Regulation of adipocyte differentiation and function by polyunsaturated fatty acids
L Madsen, RK Petersen, K Kristiansen |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2005 |
|
Transgenic animal models for the study of adipose tissue biology
M Blüher |
Best Practice & Research Clinical Endocrinology & Metabolism | 2005 |
|
Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination
SE LeBlanc, R Srinivasan, C Ferri, GM Mager, AL Gillian-Daniel, L Wrabetz, J Svaren |
Journal of Neurochemistry | 2005 |
|
Adipose Development: From Stem Cell to Adipocyte
TC Otto, MD Lane |
Critical Reviews in Biochemistry and Molecular Biology | 2005 |
|
Detection and delineation of an unusual 17p11.2 deletion by array-CGH and refinement of the Smith–Magenis syndrome minimum deletion to ~650 kb
J Schoumans, J Staaf, G Jönsson, J Rantala, KS Zimmer, Å Borg, M Nordenskjöld, BM Anderlid |
European Journal of Medical Genetics | 2005 |
|
Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic -Cells
A Takahashi, K Motomura, T Kato, T Yoshikawa, Y Nakagawa, N Yahagi, H Sone, H Suzuki, H Toyoshima, N Yamada, H Shimano |
Diabetes | 2005 |
|
High Mobility Group Protein-B1 Interacts with Sterol Regulatory Element-binding Proteins to Enhance Their DNA Binding
Y Najima, N Yahagi, Y Takeuchi, T Matsuzaka, M Sekiya, Y Nakagawa, M Amemiya-Kudo, H Okazaki, S Okazaki, Y Tamura, Y Iizuka, K Ohashi, K Harada, T Gotoda, R Nagai, T Kadowaki, S Ishibashi, N Yamada, J Osuga, H Shimano |
The Journal of biological chemistry | 2005 |
|
Overexpression of estrogen receptor α increases hepatic cholesterogenesis, leading to biliary hypersecretion in mice
HH Wang, NH Afdhal, DQ Wang |
Journal of lipid research | 2005 |
|
Overexpression of Insig-1 in livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis
Luke J. Engelking, Hiroshi Kuriyama, Robert E. Hammer, Jay D. Horton, Michael S. Brown, Joseph L. Goldstein, Guosheng Liang |
Journal of Clinical Investigation | 2004 |
|
Disruption of cholesterol homeostasis by plant sterols
Chengdong Yang, Liqing Yu, Weiping Li, Fang Xu, Jonathan C. Cohen, Helen H. Hobbs |
Journal of Clinical Investigation | 2004 |
|
Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity
J Zhang, M Fu, T Cui, C Xiong, K Xu, W Zhong, Y Xiao, D Floyd, J Liang, E Li, Q Song, YE Chen |
Proceedings of the National Academy of Sciences | 2004 |
|
Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice
JM Paterson, NM Morton, C Fievet, CJ Kenyon, MC Holmes, B Staels, JR Seckl, JJ Mullins |
Proceedings of the National Academy of Sciences | 2004 |
|
Sterol regulatory element-binding protein (SREBP)-1: gene regulatory target for insulin resistance?
J Kotzka, D Müller-Wieland |
Expert Opinion on Therapeutic Targets | 2004 |
|
SREBP transcription factors: master regulators of lipid homeostasis
D Eberlé, B Hegarty, P Bossard, P Ferré, F Foufelle |
Biochimie | 2004 |
|
Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis
R McPherson, A Gauthier |
Biochemistry and Cell Biology | 2004 |
|
Identification of Ku70/Ku80 as ADD1/SREBP1c interacting proteins
YS Lee, HY Koh, SD Park, JB Kim |
Korean Journal of Biological Sciences | 2004 |
|
Genetic linkage and expression analysis of SREBP and lipogenic genes in fat and lean chicken
S Assaf, S Lagarrigue, S Daval, M Sansom, B Leclercq, J Michel, F Pitel, M Alizadeh, A Vignal, M Douaire |
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology | 2004 |
|
Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice
T Matsuzaka, H Shimano, N Yahagi, M Amemiya-Kudo, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, S Tomita, M Sekiya, A Hasty, Y Nakagawa, H Sone, H Toyoshima, S Ishibashi, J Osuga, N Yamada |
Diabetes | 2004 |
|
Animal models for human contiguous gene syndromes and other genomic disorders
K Walz, P Fonseca, JR Lupski |
Genetics and molecular biology | 2004 |
|
Post-transcriptional Regulation of Low Density Lipoprotein Receptor Protein by Proprotein Convertase Subtilisin/Kexin Type 9a in Mouse Liver
SW Park, YA Moon, JD Horton |
The Journal of biological chemistry | 2004 |
|
Studies of the Isoprenoid-Mediated Inhibition of Mevalonate Synthesis Applied to Cancer Chemotherapy and Chemoprevention
H Mo, CE Elson |
Experimental biology and medicine (Maywood, N.J.) | 2004 |
|
The effect of sterol regulatory element-binding protein 2 polymorphism on the serum lipid in northern Chinese subjects
X Duan, W Zhu, Y Li, Z Zhang, Y Zhao, J Dao, Y Xiao |
Journal of lipid research | 2004 |
|
Reduced penetrance of craniofacial anomalies as a function of deletion size and genetic background in a chromosome engineered partial mouse model for Smith–Magenis syndrome
J Yan, VW Keener, W Bi, K Walz, A Bradley, MJ Justice, JR Lupski |
Human Molecular Genetics | 2004 |
|
Selective Coactivator Interactions in Gene Activation by SREBP-1a and -1c
JI Toth, S Datta, JN Athanikar, LP Freedman, TF Osborne |
Molecular and cellular biology | 2004 |
|
Liver-specific disruption of the peroxisome proliferator receptor gamma in diabetic mice improves fatty liver, but aggravates hyperglycemia
Kimihiko Matsusue, Martin Haluzik, Gilles Lambert, Sun-Hee Yim, Oksana Gavrilova, Jerrold M. Ward, Bryan Brewer, Marc L. Reitman, Frank J.Gonzalez |
Journal of Clinical Investigation | 2003 |
|
Keratinocyte growth factor and the transcription factors C/EBP alpha and delta and SREBP-1c regulate fatty acid synthesis in alveolar type II cells
Robert J. Mason, Tianli Pan, Karen E. Edeedn, Larry D. Nielsen, Feijie Zhang, Malinda Longphre, Michael Eckart, and Steven Neben |
Journal of Clinical Investigation | 2003 |
|
Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c
YS Lee, HH Lee, J Park, EJ Yoo, CA Glackin, YI Choi, SH Jeon, RH Seong, SD Park, JB Kim |
Nucleic Acids Research | 2003 |
|
Local regulation of fat metabolism in peripheral nerves
MH Verheijen, R Chrast, P Burrola, G Lemke |
Genes & development | 2003 |
|
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression
M Sekiya, N Yahagi, T Matsuzaka, Y Najima, M Nakakuki, R Nagai, S Ishibashi, J Osuga, N Yamada, H Shimano |
Hepatology | 2003 |
|
Effects of HIV protease inhibitor therapy on lipid metabolism
DY Hui |
Progress in Lipid Research | 2003 |
|
YM-53601, a novel squalene synthase inhibitor, suppresses lipogenic biosynthesis and lipid secretion in rodents
T Ugawa, H Kakuta, H Moritani, O Inagaki, H Shikama |
British Journal of Pharmacology | 2003 |
|
Lanosterol metabolism and sterol regulatory element binding protein (SREBP) expression in male germ cell maturation
KF Tacer, S Kalanj-Bognar, MR Waterman, D Rozman |
The Journal of Steroid Biochemistry and Molecular Biology | 2003 |
|
Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement
H Ono, H Shimano, H Katagiri, N Yahagi, H Sakoda, Y Onishi, M Anai, T Ogihara, M Fujishiro, AY Viana, Y Fukushima, M Abe, N Shojima, M Kikuchi, N Yamada, Y Oka, T Asano |
Diabetes | 2003 |
|
Genetic background of cholesterol gallstone disease
A Kosters, M Jirsa, AK Groen |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2003 |
|
Enhanced expression of hepatic lipogenic enzymes in an animal model of sedentariness
A Vecchini, V Ceccarelli, P Orvietani, P Caligiana, F Susta, L Binaglia, G Nocentini, C Riccardi, PD Nardo |
Journal of lipid research | 2003 |
|
Overexpression of Sterol Regulatory Element-binding Protein-1a in Mouse Adipose Tissue Produces Adipocyte Hypertrophy, Increased Fatty Acid Secretion, and Fatty Liver
JD Horton, I Shimomura, S Ikemoto, Y Bashmakov, RE Hammer |
The Journal of biological chemistry | 2003 |
|
Thyroid Hormone Regulation and Cholesterol Metabolism Are Connected through Sterol Regulatory Element-binding Protein-2 (SREBP-2)
DJ Shin, TF Osborne |
The Journal of biological chemistry | 2003 |
|
Skeletal Muscle Sterol Regulatory Element Binding Protein-1c Decreases with Food Deprivation and Increases with Feeding in Rats
ME Bizeau, PS MacLean, GC Johnson, Y Wei |
The Journal of nutrition | 2003 |
|
Transcription Profiling in Rat Liver in Response to Dietary Docosahexaenoic Acid Implicates Stearoyl-Coenzyme A Desaturase as a Nutritional Target for Lipid Lowering
JA Kramer, J LeDeaux, D Butteiger, T Young, C Crankshaw, H Harlow, L Kier, BG Bhat |
The Journal of nutrition | 2003 |
|
Cloning of cDNA encoding the nuclear form of chicken sterol response element binding protein-2 (SREBP-2), chromosomal localization, and tissue expression of chicken SREBP-1 and -2 genes
S Assaf, D Hazard, F Pitel, M Morisson, M Alizadeh, F Gondret, C Diot, A Vignal, M Douaire, S Lagarrigue |
Poultry science | 2003 |
|
Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) Contiguous Gene Syndromes by Chromosome Engineering in Mice: Phenotypic Consequences of Gene Dosage Imbalance
K Walz, S Caratini-Rivera, W Bi, P Fonseca, DL Mansouri, J Lynch, H Vogel, JL Noebels, A Bradley, JR Lupski |
Molecular and cellular biology | 2003 |
|
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in liver
Jay Horton, Joseph Goldstein, Michael Brown |
Journal of Clinical Investigation | 2002 |
|
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c
F Foufelle, P Ferré |
Biochemical Journal | 2002 |
|
Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion
L Yu, RE Hammer, J Li-Hawkins, KV Bergmann, D Lutjohann, JC Cohen, HH Hobbs |
Proceedings of the National Academy of Sciences | 2002 |
|
Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse
W Bi, J Yan, P Stankiewicz, SS Park, K Walz, CF Boerkoel, L Potocki, LG Shaffer, K Devriendt, MJ Nowaczyk, K Inoue, JR Lupski |
Genome research | 2002 |
|
Chicken ovalbumin upstream-promoter transcription factor and E-box-binding proteins enhance thyroid-hormone responsiveness of the malic enzyme gene in avian hepatocytes
Y Wang, Y Zhang, FB Hillgartner |
Biochemical Journal | 2002 |
|
SREBP-1: Gene Regulatory Key to Syndrome X?
D Müller-Wieland, J Kotzka |
Annals of the New York Academy of Sciences | 2002 |
|
Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes
M Amemiya-Kudo, H Shimano, AH Hasty, N Yahagi, T Yoshikawa, T Matsuzaka, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, J Osuga, K Harada, T Gotoda, R Sato, S Kimura, S Ishibashi, N Yamada |
Journal of lipid research | 2002 |
|
Genetic Manipulations of Fatty Acid Metabolism in -Cells Are Associated With Dysregulated Insulin Secretion
K Eto, T Yamashita, J Matsui, Y Terauchi, M Noda, T Kadowaki |
Diabetes | 2002 |
|
Hypercholesterolemia in children with Smith-Magenis syndrome: del (17) (p11.2p11.2)
Ann C M Smith, Andrea L Gropman, Joan E Bailey-Wilson, Ozlem Goker-Alpan, Sarah H Elsea, Jan Blancato, James R Lupski, Lorraine Potocki |
Genetics in Medicine | 2002 |
|
A low fish oil inhibits SREBP-1 proteolytic cascade, while a high-fish-oil feeding decreases SREBP-1 mRNA in mice liver: relationship to anti-obesity
T Nakatani, HJ Kim, Y Kaburagi, K Yasuda, O Ezaki |
Journal of lipid research | 2002 |
|
A Soy Protein Diet Alters Hepatic Lipid Metabolism Gene Expression and Reduces Serum Lipids and Renal Fibrogenic Cytokines in Rats with Chronic Nephrotic Syndrome
AR Tovar, F Murguía, C Cruz, R Hernández-Pando, CA Aguilar-Salinas, J Pedraza-Chaverri, R Correa-Rotter, N Torres |
The Journal of nutrition | 2002 |
|
Octanoate Attenuates Adipogenesis in 3T3-L1 Preadipocytes
J Han, SR Farmer, JL Kirkland, BE Corkey, R Yoon, T Pirtskhalava, Y Ido, W Guo |
The Journal of nutrition | 2002 |
|
HMG-CoA Reductase Inhibitors
G Schmitz, M Torzewski |
2002 | |
|
Steroid Hormones and Cell Cycle Regulation
KL Burnstein |
2002 | |
|
Understanding adipose tissue development from transgenic animal models
P Valet, G Tavernier, I Castan-Laurell, JS Saulnier-Blache, D Langin |
Journal of lipid research | 2002 |
|
Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice
C Vasandani, AI Kafrouni, A Caronna, Y Bashmakov, M Gotthardt, JD Horton, DK Spady |
Journal of lipid research | 2002 |
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Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs
T Matsuzaka, H Shimano, N Yahagi, T Yoshikawa, M Amemiya-Kudo, AH Hasty, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, J Osuga, A Takahashi, S Yato, H Sone, S Ishibashi, N Yamada |
Journal of lipid research | 2002 |
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Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα
T Matsuzaka, H Shimano, N Yahagi, M Amemiya-Kudo, T Yoshikawa, AH Hasty, Y Tamura, J Osuga, H Okazaki, Y Iizuka, A Takahashi, H Sone, T Gotoda, S Ishibashi, N Yamada |
Journal of lipid research | 2002 |
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Tissue-specific transcriptional regulation of the cholesterol biosynthetic pathway leads to accumulation of testis meiosis-activating sterol (T-MAS)
KF Tacer, TB Haugen, M Baltsen, N Debeljak, D Rozman |
Journal of lipid research | 2002 |
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Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene
J Yang, JL Goldstein, RE Hammer, YA Moon, MS Brown, JD Horton |
Proceedings of the National Academy of Sciences | 2001 |
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SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
M Matsuda, BS Korn, RE Hammer, YA Moon, R Komuro, JD Horton, JL Goldstein, MS Brown, I Shimomura |
Genes & development | 2001 |
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Mechanisms of nutritional and hormonal regulation of lipogenesis
S Kersten |
EMBO reports | 2001 |
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Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes
H Shimano |
Progress in Lipid Research | 2001 |
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Proteolytic Activation of SREBPs during Adipocyte Differentiation
J Inoue, H Kumagai, T Terada, M Maeda, M Shimizu, R Sato |
Biochemical and Biophysical Research Communications | 2001 |
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Acute Inhibition of Glucose-6-Phosphate Translocator Activity Leads to Increased De Novo Lipogenesis and Development of Hepatic Steatosis Without Affecting VLDL Production in Rats
RH Bandsma, CH Wiegman, AW Herling, HJ Burger, A Harmsel, AJ Meijer, JA Romijn, DJ Reijngoud, F Kuipers |
Diabetes | 2001 |
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Adenovirus-Mediated Overexpression of Sterol Regulatory Element Binding Protein-1c Mimics Insulin Effects on Hepatic Gene Expression and Glucose Homeostasis in Diabetic Mice
D Becard, I Hainault, D Azzout-Marniche, L Bertry-Coussot, P Ferre, F Foufelle |
Diabetes | 2001 |
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Regulation of lipid metabolism and gene expression by fenofibrate in hamsters
Q Guo, PR Wang, DP Milot, MC Ippolito, M Hernandez, CA Burton, SD Wright, Y Chao |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2001 |
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Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter
T Yoshikawa, H Shimano, M Amemiya-Kudo, N Yahagi, AH Hasty, T Matsuzaka, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, JI Osuga, K Harada, T Gotoda, S Kimura, S Ishibashi, N Yamada |
Molecular and cellular biology | 2001 |
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Functional analysis of secreted and transmembrane proteins critical to mouse development
KJ Mitchell, KI Pinson, OG Kelly, J Brennan, J Zupicich, P Scherz, PA Leighton, LV Goodrich, X Lu, BJ Avery, P Tate, K Dill, E Pangilinan, P Wakenight, M Tessier-Lavigne, WC Skarnes |
Nature Genetics | 2001 |
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Genomic organisation of the ∼1.5 Mb Smith-Magenis syndrome critical interval: Transcription map, genomic contig, and candidate gene analysis
RE Lucas, CN Vlangos, P Das, PI Patel, SH Elsea |
European Journal of Human Genetics | 2001 |
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Intestinal Lipid Metabolism
CM Mansbach, P Tso, A Kuksis |
2001 | |
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A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis
M Miyazaki, YC Kim, JM Ntambi |
Journal of lipid research | 2001 |
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Molecular mechanisms of adipocyte differentiation
Q Tong, G S Hotamisligil |
Reviews in Endocrine and Metabolic Disorders | 2001 |
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Lipid metabolism
J Stocks |
Current Opinion in Lipidology | 2000 |
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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
JJ Repa, G Liang, J Ou, Y Bashmakov, JM Lobaccaro, I Shimomura, B Shan, MS Brown, JL Goldstein, DJ Mangelsdorf |
Genes & development | 2000 |
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Structure and regulation of mammalian squalene synthase
T Tansey |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2000 |
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Transcriptional control of adipogenesis
SM Rangwala, MA Lazar |
Annual Review of Nutrition | 2000 |
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LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptors in transgenic rabbits
ME Brousseau, RD Kauffman, EE Herderick, SJ Demosky, W Evans, S Marcovina, S Santamarina-Fojo, HB Brewer, JM Hoeg |
Arteriosclerosis, thrombosis, and vascular biology | 2000 |
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Sterol Regulatory Element-Binding Protein-1 Participates in the Regulation of Fatty Acid Synthase Expression in Colorectal Neoplasia
JN Li, MA Mahmoud, WF Han, M Ripple, ES Pizer |
Experimental Cell Research | 2000 |
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Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action
TF Osborne |
The Journal of biological chemistry | 2000 |
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Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene
M Amemiya-Kudo, H Shimano, T Yoshikawa, N Yahagi, AH Hasty, H Okazaki, Y Tamura, F Shionoiri, Y Iizuka, K Ohashi, J Osuga, K Harada, T Gotoda, R Sato, S Kimura, S Ishibashi, N Yamada |
The Journal of biological chemistry | 2000 |
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Sterol Regulatory Element-binding Protein-1 Is Regulated by Glucose at the Transcriptional Level
AH Hasty, H Shimano, N Yahagi, M Amemiya-Kudo, S Perrey, T Yoshikawa, J Osuga, H Okazaki, Y Tamura, Y Iizuka, F Shionoiri, K Ohashi, K Harada, T Gotoda, R Nagai, S Ishibashi, N Yamada |
The Journal of biological chemistry | 2000 |
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Oxysterols: Modulators of Cholesterol Metabolism and Other Processes
GJ Schroepfer |
Physiological reviews | 2000 |
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Hormonal Signaling and Transcriptional Control of Adipocyte Differentiation
RF Morrison, SR Farmer |
The Journal of nutrition | 2000 |
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Lipoprotein Metabolism and Atherogenesis
T Kita, M Yokode |
2000 | |
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Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
H Shimano, JD Horton, RE Hammer, I Shimomura, MS Brown, JL Goldstein |
Journal of Clinical Investigation | 1999 |
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STEROLS AND ISOPRENOIDS: Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway
PA Edwards, J Ericsson |
Annual Review of Biochemistry | 1999 |
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Alteration of SREBP Activation in Liver of Trisomy 21 Fetuses
L Diomede, M Salmona, D Albani, M Bianchi, A Bruno, S Salmona, U Nicolini |
Biochemical and Biophysical Research Communications | 1999 |
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Sterol regulatory element-binding proteins
JD Morton, L Shimomura |
Current Opinion in Lipidology | 1999 |
|
Insights into the transcriptional control of adipocyte differentiation
RF Morrison, SR Farmer |
Journal of Cellular Biochemistry | 1999 |
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Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
H Shimano, JD Horton, RE Hammer, I Shimomura, MS Brown, JL Goldstein |
Journal of Biological Chemistry | 1999 |
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Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
I Shimomura, Y Bashmakov, JD Horton |
The Journal of biological chemistry | 1999 |
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A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
N Yahagi, H Shimano, AH Hasty, M Amemiya-Kudo, H Okazaki, Y Tamura, Y Iizuka, F Shionoiri, K Ohashi, J Osuga, K Harada, T Gotoda, R Nagai, S Ishibashi, N Yamada |
The Journal of biological chemistry | 1999 |
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Sterol Response Element-binding Protein 1c (SREBP1c) Is Involved in the Polyunsaturated Fatty Acid Suppression of Hepatic S14 Gene Transcription
MK Mater, AP Thelen, DA Pan, DB Jump |
The Journal of biological chemistry | 1999 |
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Essential Role in Vivo of Upstream Stimulatory Factors for a Normal Dietary Response of the Fatty Acid Synthase Gene in the Liver
M Casado, VS Vallet, A Kahn, S Vaulont |
The Journal of biological chemistry | 1999 |
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Fish Oil Feeding Decreases Mature Sterol Regulatory Element-binding Protein 1 (SREBP-1) by Down-regulation of SREBP-1c mRNA in Mouse Liver: A POSSIBLE MECHANISM FOR DOWN-REGULATION OF LIPOGENIC ENZYME mRNAs
HJ Kim, M Takahashi, O Ezaki |
The Journal of biological chemistry | 1999 |
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Signal Transduction From the Endoplasmic Reticulum to the Cell Nucleus
HL Pahl |
Physiological reviews | 1999 |
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The physiological role of sterol regulatory element-binding protein-2 in cultured human cells
Y Kawabe, T Suzuki, M Hayashi, T Hamakubo, R Sato, T Kodama |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 1999 |
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Human Growth Hormone Increases Apo(a) Expression in Transgenic Mice
R Tao, F Acquati, SM Marcovina, HH Hobbs |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
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ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose
M Foretz, C Pacot, I Dugail, P Lemarchand, C Guichard, X le Lièpvre, C Berthelier-Lubrano, B Spiegelman, JB Kim, P Ferré, F Foufelle |
Molecular and cellular biology | 1999 |
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Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a, -2, and YY1
B Gauthier, M Robb, F Gaudet, GS Ginsburg, R McPherson |
Journal of lipid research | 1999 |
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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2
JD Horton, I Shimomura, MS Brown, RE Hammer, JL Goldstein, H Shimano |
Journal of Clinical Investigation | 1998 |
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Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N)
BS Korn, I Shimomura, Y Bashmakov, RE Hammer, JD Horton, JL Goldstein, MS Brown |
Journal of Clinical Investigation | 1998 |
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Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy
I Shimomura, RE Hammer, JA Richardson, S Ikemoto, Y Bashmakov, JL Goldstein, MS Brown |
Genes & development | 1998 |
|
Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
JD Horton, Y Bashmakov, I Shimomura, H Shimano |
Proceedings of the National Academy of Sciences | 1998 |
|
Signaling molecules derived from the cholesterol biosynthetic pathway: mechanisms of action and possible roles in human disease
PA Edwards, J Ericsson |
Current Opinion in Lipidology | 1998 |
|
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
DJ Peet, SD Turley, W Ma, BA Janowski, JM Lobaccaro, RE Hammer, DJ Mangelsdorf |
Cell | 1998 |
|
Obesity-related Overexpression of Fatty-acid Synthase Gene in Adipose Tissue Involves Sterol Regulatory Element-binding Protein Transcription Factors
M Boizard, XL Liepvre, P Lemarchand, F Foufelle, P Ferré, I Dugail |
The Journal of biological chemistry | 1998 |
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Oleate Potentiates Oxysterol Inhibition of Transcription from Sterol Regulatory Element-1-regulated Promoters and Maturation of Sterol Regulatory Element-binding Proteins
DP Thewke, SR Panini, M Sinensky |
The Journal of biological chemistry | 1998 |
|
HLH106, a Drosophila Sterol Regulatory Element-binding Protein in a Natural Cholesterol Auxotroph
JM Rosenfeld, TF Osborne |
The Journal of biological chemistry | 1998 |
|
Utility and Importance of Gene Knockout Animals For Nutritional and Metabolic Research
DY Hui |
The Journal of nutrition | 1998 |
|
Advances in Molecular and Cellular Endocrinology
MR Pollak, EM Brown |
Advances in Molecular and Cellular Endocrinology | 1997 |
|
Progress in Nucleic Acid Research and Molecular Biology
FS Collins, SM Weissman |
Progress in nucleic acid research and molecular biology | 1984 |
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