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M Shimabukuro, … , Y Lee, R H Unger
Published July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):290-295. https://doi.org/10.1172/JCI119534.
Citation Information: J Clin Invest. 1997;100(2):290-295. https://doi.org/10.1172/JCI119534.
Abstract
Research Article
Authors
M Shimabukuro, M Ohneda, Y Lee, R H Unger
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Citations to this article (228)
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Expression of islet inducible nitric oxide synthase and inhibition of glucose-stimulated insulin release after long-term lipid infusion in the rat is counteracted by PACAP27
SS Qader, J Jimenez-Feltström, M Ekelund, I Lundquist, A Salehi |
American journal of physiology. Endocrinology and metabolism | 2007 |
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Inhibition of Inducible Nitric Oxide Synthase Prevents Hepatic, but Not Pulmonary, Injury Following Ischemia-Reperfusion of Rat Liver
Y Takamatsu, K Shimada, K Yamaguchi, S Kuroki, K Chijiiwa, M Tanaka |
Digestive Diseases and Sciences | 2006 |
|
The metabolic syndrome: evolving evidence that thiazolidinediones provide rational therapy
KL Wyne |
Diabetes, Obesity and Metabolism | 2006 |
|
Palmitate induced lipoapoptosis of exocrine pancreas AR42J cells
Z Landau, E Forti, M Alcaly, RZ Birk |
Apoptosis | 2006 |
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Protein kinase B/Akt signalling is required for palmitate-induced beta-cell lipotoxicity
M Higa, M Shimabukuro, Y Shimajiri, N Takasu, T Shinjyo, T Inaba |
Diabetes, Obesity and Metabolism | 2006 |
|
Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells
AK Azevedo-Martins, AP Monteiro, CL Lima, S Lenzen, R Curi |
Toxicology in Vitro | 2006 |
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Bax inhibition protects against free fatty acid-induced lysosomal permeabilization
AE Feldstein, NW Werneburg, Z Li, SF Bronk, GJ Gores |
American journal of physiology. Gastrointestinal and liver physiology | 2006 |
|
Diabetic Dyslipidemia and the Heart
AR Vasudevan, AJ Garber |
Heart Failure Clinics | 2006 |
|
Selective induction of inducible nitric oxide synthase in pancreatic islet of rat after an intravenous glucose or intralipid challenge
M Ekelund, SS Qader, J Jimenez-Feltstrom, A Salehi |
Nutrition | 2006 |
|
Relationship between fatty acids and the endocrine and neuroendocrine system
SJ Bhathena |
Nutritional Neuroscience | 2006 |
|
Protection of INS-1 cells from free fatty acid-induced apoptosis by targeting hOGG1 to mitochondria
Lyudmila I Rachek, Nancy P Thornley, Valentina I Grishko, Susan P LeDoux, Glenn L Wilson |
Diabetes | 2006 |
|
Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance
SM Turpin, GI Lancaster, I Darby, MA Febbraio, MJ Watt |
American journal of physiology. Endocrinology and metabolism | 2006 |
|
Bax inhibition protects against free fatty acid-induced lysosomal permeabilization
AE Feldstein, NW Werneburg, ZZ Li, SF Bronk, GJ Gores |
AJP Gastrointestinal and Liver Physiology | 2006 |
|
Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker diabetic fatty rat islets: a functional and gene profiling analysis
LE Parton, PJ McMillen, Y Shen, E Docherty, E Sharpe, F Diraison, CP Briscoe, GA Rutter |
American journal of physiology. Endocrinology and metabolism | 2006 |
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Sphingosine 1-Phosphate Affects Cytokine-Induced Apoptosis in Rat Pancreatic Islet β-Cells
SG Laychock, SM Sessanna, MH Lin, LD Mastrandrea |
Endocrinology | 2006 |
|
A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death
NM Borradaile, KK Buhman, LL Listenberger, CJ Magee, ET Morimoto, DS Ory, JE Schaffer |
Molecular biology of the cell | 2005 |
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S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance
MA Carvalho-Filho, M Ueno, SM Hirabara, AB Seabra, JB Carvalheira, MG de Oliveira, LA Velloso, R Curi, MJ Saad |
Diabetes | 2005 |
|
Longevity, lipotoxicity and leptin: the adipocyte defense against feasting and famine
RH Unger |
Biochimie | 2005 |
|
Development and application of rodent models for type 2 diabetes
D Chen, MW Wang |
Diabetes, Obesity and Metabolism | 2005 |
|
Relationship between DNA damage, total antioxidant capacity and coronary artery disease
R Demirbag, R Yilmaz, A Kocyigit |
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2005 |
|
Involvement of mtDNA damage in free fatty acid-induced apoptosis
V Grishko, L Rachek, S Musiyenko, SP LeDoux, GL Wilson |
Free radical biology & medicine | 2005 |
|
Mechanisms of Pancreatic -Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities
M Cnop, N Welsh, JC Jonas, A Jorns, S Lenzen, DL Eizirik |
Diabetes | 2005 |
|
Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity
Brian T Noronha, Jian-Mei Li, Stephen B Wheatcroft, Ajay M Shah, Mark T Kearney |
Diabetes | 2005 |
|
Imaging beta-cell death with a near-infrared probe
Zdravka Medarova, Susan Bonner-Weir, Myra Lipes, Anna Moore |
Diabetes | 2005 |
|
Molecular Cardiology
Z Sun |
2005 | |
|
Inflammation, stress, and diabetes.
Wellen KE, Hotamisligil GS |
Journal of Clinical Investigation | 2005 |
|
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress
I Kharroubi, L Ladrière, AK Cardozo, Z Dogusan, M Cnop, DL Eizirik |
Endocrinology | 2004 |
|
Effects of dietary fatty acids on insulin sensitivity and secretion
M Manco, M Calvani, G Mingrone |
Diabetes, Obesity and Metabolism | 2004 |
|
A Comparison of Agents Used to Manage Type 2 Diabetes Mellitus
DS Bell |
Treatments in Endocrinology | 2004 |
|
Management of Type 2 Diabetes With Thiazolidinediones
DS Bell |
The Endocrinologist | 2004 |
|
Type 2 diabetes mellitus: what is the optimal treatment regimen?
DS Bell |
The American Journal of Medicine | 2004 |
|
Cilostazol, a phosphodiesterase inhibitor, reduces microalbuminuria in the insulin-resistant Otsuka Long-Evans Tokushima Fatty rat
T Tohma, M Shimabukuro, Y Oshiro, M Yamakawa, Y Shimajiri, N Takasu |
Metabolism | 2004 |
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Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion
Patrick C Moore, Marco A Ugas, Derek K Hagman, Susan D Parazzoli, Vincent Poitout |
Diabetes | 2004 |
|
Inhibition of Inducible Nitric-oxide Synthase by Activators of AMP-activated Protein Kinase: A NEW MECHANISM OF ACTION OF INSULIN-SENSITIZING DRUGS
G Pilon, P Dallaire, A Marette |
The Journal of biological chemistry | 2004 |
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Impact of PPARγ overexpression and activation on pancreatic islet gene expression profile analyzed with oligonucleotide microarrays
LE Parton, F Diraison, SE Neill, SK Ghosh, MA Rubino, JE Bisi, CP Briscoe, GA Rutter |
American journal of physiology. Endocrinology and metabolism | 2004 |
|
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
LL Listenberger, X Han, SE Lewis, S Cases, RV Farese, DS Ory, JE Schaffer |
Proceedings of the National Academy of Sciences | 2003 |
|
Lipotoxicity: when tissues overeat:
JE Schaffer |
2003 | |
|
β-Cell rejuvenation with thiazolidinediones
DS Bell |
The American Journal of Medicine | 2003 |
|
WHY I INITIATE THERAPY WITH TWO INSULIN SENSITIZERS IN PATIENTS WITH TYPE 2 DIABETES
DS FACP |
Endocrine Practice | 2003 |
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Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells
Katrin Eitel, Harald Staiger, Johannes Rieger, Harald Mischak, Heide Brandhorst, Mathias D Brendel, Reinhard G Bretzel, Hans-Ulrich Häring, Monika Kellerer |
Diabetes | 2003 |
|
Visualizing Superoxide Production in Normal and Diabetic Rat Islets of Langerhans
VP Bindokas, A Kuznetsov, S Sreenan, KS Polonsky, MW Roe, LH Philipson |
The Journal of biological chemistry | 2003 |
|
Mitochondrial Dysfunction Is Involved in Apoptosis Induced by Serum Withdrawal and Fatty Acids in the β-Cell Line Ins-1
I Maestre, J Jordán, S Calvo, JA Reig, V Ceña, B Soria, M Prentki, E Roche |
Endocrinology | 2003 |
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Cardiomyocyte over-expression of iNOS in mice results in peroxynitrite generation, heart block and sudden death
Imran N. Mungrue, Robert Gros, Xiaomang You, Asif Pirani, Azar Azad3, Tamas Csont, Richard Schulz, Jagdish Butany, Duncan J. Stewart & Mansoor Husain |
Journal of Clinical Investigation | 2002 |
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Lipotoxic diseases
RH Unger |
Annual Review of Medicine | 2002 |
|
Effects of free fatty acids on insulin secretion in obesity
S Zraika, M Dunlop, J Proietto, S Andrikopoulos |
Obesity Reviews | 2002 |
|
Pleiotropic effects of fatty acids on pancreatic ?-cells
EP Haber, HM Ximenes, J Proc�pio, CR Carvalho, R Curi, AR Carpinelli |
Journal of Cellular Physiology | 2002 |
|
REGULATION OFNITRICOXIDESYNTHESIS BYDIETARYFACTORS
G Wu, CJ Meininger |
Annual Review of Nutrition | 2002 |
|
Probucol preserves pancreatic β-cell function through reduction of oxidative stress in type 2 diabetes
S Gorogawa, Y Kajimoto, Y Umayahara, H Kaneto, H Watada, A Kuroda, D Kawamori, T Yasuda, M Matsuhisa, Y Yamasaki, M Hori |
Diabetes Research and Clinical Practice | 2002 |
|
R EGULATION OF N ITRIC O XIDE S YNTHESIS BY D IETARY F ACTORS
G Wu, CJ Meininger |
Annual Review of Nutrition | 2002 |
|
Evidence for a deficient pancreatic β-cell response in a rat model of hyperthyroidism
M Fukuchi, M Shimabukuro, Y Shimajiri, Y Oshiro, M Higa, H Akamine, I Komiya, N Takasu |
Life Sciences | 2002 |
|
Lovastatin does not accentuate but is rather additive to palmitate-induced apoptosis in cardiomyocytes
JY Kong, SW Rabkin |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2002 |
|
Stimulation of Acetyl-CoA Carboxylase Gene Expression by Glucose Requires Insulin Release and Sterol Regulatory Element Binding Protein 1c in Pancreatic MIN6 -Cells
C Andreolas, GS Xavier, F Diraison, C Zhao, A Varadi, F Lopez-Casillas, P Ferre, F Foufelle, GA Rutter |
Diabetes | 2002 |
|
Increased Proinsulin Levels and Decreased Acute Insulin Response Independently Predict the Incidence of Type 2 Diabetes in the Insulin Resistance Atherosclerosis Study
AJ Hanley, R D'Agostino, LE Wagenknecht, MF Saad, PJ Savage, R Bergman, SM Haffner |
Diabetes | 2002 |
|
Protective effect of D-glucose, L-leucine and fetal calf serum against oxidative stress in neonatal pancreatic islets
Luiz F Stoppiglia, Tatiane A Nogueira, Adriana R Leite, Everardo M Carneiro, Antonio C Boschero |
Biochimica et Biophysica Acta | 2002 |
|
Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance
H Sugita, M Kaneki, E Tokunaga, M Sugita, C Koike, S Yasuhara, RG Tompkins, JA Martyn |
American journal of physiology. Endocrinology and metabolism | 2002 |
|
Impact of mitochondrial β-oxidation in fatty acid-mediated inhibition of glioma cell proliferation
K Berge, KJ Tronstad, P Bohov, L Madsen, RK Berge |
Journal of lipid research | 2002 |
|
Δ6-, Stearoyl CoA-, and Δ5-desaturase enzymes are expressed in β-cells and are altered by increases in exogenous PUFA concentrations
S Ramanadham, S Zhang, Z Ma, M Wohltmann, A Bohrer, FF Hsu, J Turk |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2002 |
|
Cross-Sectional and Prospective Associations between Abdominal Adiposity and Proinsulin Concentration
AJ Hanley, G McKeown-Eyssen, SB Harris, RA Hegele, TM Wolever, J Kwan, B Zinman |
The Journal of clinical endocrinology and metabolism | 2002 |
|
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation
M Cnop, JC Hannaert, A Hoorens, DL Eizirik, DG Pipeleers |
Diabetes | 2001 |
|
TPN-evoked dysfunction of islet lysosomal activity mediates impairment of glucose-stimulated insulin release
A Salehi, BG Fan, M Ekelund, G Nordin, I Lundquist |
American journal of physiology. Endocrinology and metabolism | 2001 |
|
Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids
I Briaud, JS Harmon, CL Kelpe, VB Segu, V Poitout |
Diabetes | 2001 |
|
Lipotoxicity of the Pancreatic β-Cell Is Associated With Glucose-Dependent Esterification of Fatty Acids Into Neutral Lipids
I Briaud, JS Harmon, CL Kelpe, VB Segu, V Poitout |
Diabetes | 2001 |
|
TISSUE TRIGLYCERIDE LEVELS IN TYPE 2 DIABETES AND THE ROLE OF THIAZOLIDINEDIONES IN REVERSING THE EFFECTS OF TISSUE HYPERTRIGLYCERIDEMIA: REVIEW OF THE EVIDENCE IN ANIMALS AND HUMANS
DS FACE, FO FACE |
Endocrine Practice | 2001 |
|
Cross-Sectional and Prospective Associations Between Proinsulin and Cardiovascular Disease Risk Factors in a Population Experiencing Rapid Cultural Transition
AJ Hanley, G McKeown-Eyssen, SB Harris, RA Hegele, TM Wolever, J Kwan, PW Connelly, B Zinman |
Diabetes care | 2001 |
|
Lipotoxicity of the Pancreatic -Cell Is Associated With Glucose-Dependent Esterification of Fatty Acids Into Neutral Lipids
I Briaud, JS Harmon, CL Kelpe, VB Segu, V Poitout |
Diabetes | 2001 |
|
Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
M Perreault, A Marette |
Nature Medicine | 2001 |
|
Palmitate-induced Apoptosis Can Occur through a Ceramide-independent Pathway
LL Listenberger, DS Ory, JE Schaffer |
The Journal of biological chemistry | 2001 |
|
Diseases of liporegulation: new perspective on obesity and related disorders
RH Unger, L Orci |
The FASEB Journal | 2001 |
|
Leptin Increases the Viability of Isolated Rat Pancreatic Islets by Suppressing Apoptosis
S Okuya, K Tanabe, Y Tanizawa, Y Oka |
Endocrinology | 2001 |
|
Insulinorezistentnost' v patogeneze sakharnogo diabeta 2 tipa
MI Balabolkin, EM Klebanova |
Diabetes mellitus | 2001 |
|
Total parenteral nutrition modulates hormone release by stimulating expression and activity of inducible nitric oxide synthase in rat pancreatic islets.
Salehi A, Ekelund M, Henningsson R, Lundquist I |
Endocrine | 2001 |
|
Nutrient toxicity in pancreatic β-cell dysfunction
E Roche, I Maestre, F Martín, E Fuentes, J Casero, JA Reig, B Soria |
Journal of Physiology and Biochemistry | 2000 |
|
Electrospray ionization mass spectrometric analyses of changes in tissue phospholipid molecular species during the evolution of hyperlipidemia and hyperglycemia in Zucker diabetic fatty rats
FF Hsu, A Bohrer, M Wohltmann, S Ramanadham, Z Ma, K Yarasheski, J Turk |
Lipids | 2000 |
|
Rosiglitazone prevents the onset of hyperglycaemia and proteinuria in the Zucker diabetic fatty rat
SA Smith, CA Lister, CD Toseland, RE Buckingham |
Diabetes, Obesity and Metabolism | 2000 |
|
Lipotoxic heart disease in obese rats: implications for human obesity
YT Zhou, P Grayburn, A Karim, M Shimabukuro, M Higa, D Baetens, L Orci, RH Unger |
Proceedings of the National Academy of Sciences | 2000 |
|
Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long–Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus
S Kagota, Y Yamaguchi, K Nakamura, M Kunitomo |
General Pharmacology: The Vascular System | 2000 |
|
Biology of nitric oxide signaling
L Liaudet, F G Soriano, C Szabó |
Critical Care Medicine | 2000 |
|
Protein Kinase Cδ Activation by Interleukin-1β Stabilizes Inducible Nitric-oxide Synthase mRNA in Pancreatic β-Cells
L Carpenter, D Cordery, TJ Biden |
The Journal of biological chemistry | 2000 |
|
Electrospray ionization mass spectrometric analyses of phospholipids from INS-1 insulinoma cells: comparison to pancreatic islets and effects of fatty acid supplementation on phospholipid composition and insulin secretion
S Ramanadham, FF Hsu, S Zhang, A Bohrer, Z Ma, J Turk |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2000 |
|
Niacinamide therapy for osteoarthritis – does it inhibit nitric oxide synthase induction by interleukin-1 in chondrocytes?
MF McCarty, AL Russell |
Medical Hypotheses | 1999 |
|
Structural characterization of triacylglycerols as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisionally activated dissociation on a triple stage quadrupole instrument
FF Hsu, J Turk |
Journal of the American Society for Mass Spectrometry | 1999 |
|
Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats
M Higa, YT Zhou, M Ravazzola, D Baetens, L Orci, RH Unger |
Proceedings of the National Academy of Sciences | 1999 |
|
Nitric oxide-cyclic GMP system potentiates glucose-induced rise in cytosolic Ca2+ concentration in rat pancreatic β-cells
N Matsuura, T Ishikawa, S Abe, H Yuyama, F Sugino, K Ishii, K Nakayama |
Life Sciences | 1999 |
|
Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells
L Segall, N Lameloise, F Assimacopoulos-Jeannet, E Roche, P Corkey, S Thumelin, BE Corkey, M Prentki |
American journal of physiology. Endocrinology and metabolism | 1999 |
|
Different Frequencies of Inducible Nitric Oxide Synthase Genotypes in Older Hypertensives
CL Glenn, WY Wang, BJ Morris |
Hypertension | 1999 |
|
Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus
J Seufert, GC Weir, JF Habener |
Journal of Clinical Investigation | 1998 |
|
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion
C Szabó, VL Dawson |
Trends in Pharmacological Sciences | 1998 |
|
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes
M Shimabukuro, YT Zhou, M Levi, RH Unger |
Proceedings of the National Academy of Sciences | 1998 |
|
Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression
M Shimabukuro, MY Wang, YT Zhou, CB Newgard, RH Unger |
Proceedings of the National Academy of Sciences | 1998 |
|
Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells
YT Zhou, M Shimabukuro, MY Wang, Y Lee, M Higa, JL Milburn, CB Newgard, RH Unger |
Proceedings of the National Academy of Sciences | 1998 |
|
OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype
MY Wang, K Koyama, M Shimabukuro, CB Newgard, RH Unger |
Proceedings of the National Academy of Sciences | 1998 |
|
Role of peroxisome proliferator-activated receptor in disease of pancreatic cells
YT Zhou, M Shimabukuro, MY Wang, Y Lee, M Higa, JL Milburn, CB Newgard, RH Unger |
Proceedings of the National Academy of Sciences | 1998 |
|
Reoxygenation injury affects isolated islet response to fatty acid stimulation
S Pitchumoni, MR Garfinkel, ED Littman, EC Opara |
Metabolism | 1998 |
|
Protection against lipoapoptosis of cells through leptin-dependent maintenance of Bcl-2 expression
M Shimabukuro, MY Wang, YT Zhou, CB Newgard, RH Unger |
Proceedings of the National Academy of Sciences | 1998 |
|
Troglitazone Lowers Islet Fat and Restores Beta Cell Function of Zucker Diabetic Fatty Rats
M Shimabukuro, YT Zhou, Y Lee, RH Unger |
The Journal of biological chemistry | 1998 |
|
Lipoapoptosis in Beta-cells of Obese Prediabetic fa/fa Rats: ROLE OF SERINE PALMITOYLTRANSFERASE OVEREXPRESSION
M Shimabukuro, M Higa, YT Zhou, MY Wang, CB Newgard, RH Unger |
The Journal of biological chemistry | 1998 |
|
Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity
M Shimabukuro, K Koyama, Y Lee, RH Unger |
Journal of Clinical Investigation | 1997 |
|
Inducible nitric oxide synthase: what difference does it make?
C Nathan |
Journal of Clinical Investigation | 1997 |
|
Leptin Normalizes the Impaired Response of Proinsulin mRNA to Long Chain Fatty Acids in Heterozygous Zucker Diabetic Fatty Rats
YT Zhou, M Shimabukuro, Y Lee, K Koyama, F Trieu, RH Unger |
The Journal of biological chemistry | 1997 |
|
Nitric Oxide
RA Schroeder, PC Kuo |
Anesthesia & Analgesia | 1995 |
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