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Citations to this article

Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein.
C Gabay, … , D Eidlen, W P Arend
C Gabay, … , D Eidlen, W P Arend
Published June 15, 1997
Citation Information: J Clin Invest. 1997;99(12):2930-2940. https://doi.org/10.1172/JCI119488.
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Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein.

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Abstract

Interleukin 1 receptor antagonist (IL-1Ra) levels are elevated in the blood of patients with a variety of infectious, immune, or traumatic conditions. To examine whether IL1Ra is produced by liver cells with characteristics resembling an acute-phase protein, human primary hepatocytes isolated from liver biopsies and HepG2 hepatoma cells were stimulated with IL-1beta, IL-6, and TNFalpha. IL-1Ra was present in the supernatants of both cells, with production significantly enhanced by IL-1beta, and by the combination of IL-1beta and IL-6. The term IL-1Ra refers to two different proteins encoded by the same gene, but generated by alternative splicing of two different first exons. One isoform is secreted (17-kD sIL-1Ra), and the other isoform remains in the cytoplasm (18-kD icIL-1Ra). By Western blot analysis, the supernatants of human hepatoma (HepG2) cells contained only sIL-1Ra, whereas the lysates contained a novel smaller molecular mass isoform of 16 kD. RT-PCR and ribonuclease protection assay with RNA from HepG2 cells showed that only sIL-1Ra mRNA was expressed, and confirmed the inducing effect of IL-1beta and IL-6. Transfection studies were performed using constructs containing the promoters of either sIL-1Ra or icIL-1Ra coupled to the luciferase reporter gene. The sIL-1Ra promoter was active in HepG2 cells stimulated by IL-1beta and/or IL-6, whereas the icIL-1Ra promoter was inactive. Mutation of binding sites for transcription factors NF-kappaB and/or C/EBP within the proximal sIL-1Ra promoter led to significant decreases in response to IL-1beta and IL-6 in comparison to the wild-type promoter. Electromobility gel shift assays confirmed the presence of NF-kappaB and C/EBP binding sites within the sIL-1Ra promoter, and indicated a significant increase in the binding activities of nuclear proteins from HepG2 cells treated with IL-1beta and IL-6. In summary, sIL-1Ra, but not icIL-1Ra, is produced by hepatocytes, and is regulated by proinflammatory cytokines as an acute-phase protein. In addition, NF-kappaB and C/EBP family members are likely to play important roles in the full expression of IL-1Ra by hepatocytes during inflammatory conditions.

Authors

C Gabay, M F Smith, D Eidlen, W P Arend

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KE Torres-Chávez, L Fischer, JM Teixeira, NC Fávaro-Moreira, GA Obando-Pereda, CA Parada, CH Tambeli
Inflammation 2010
Protective effect of recombinant human IL-1Ra on CCl4-induced acute liver injury in mice
RZ Zhu, D Xiang, C Xie, JJ Li, JJ Hu, HL He, YS Yuan, J Gao, W Han, Y Yu
World journal of gastroenterology : WJG 2010
Why not treat human cancer with interleukin-1 blockade?
CA Dinarello
Cancer metastasis reviews 2010
Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study
S Stenholm, A Koster, DE Alley, M Visser, M Maggio, TB Harris, JM Egan, S Bandinelli, JM Guralnik, L Ferrucci
Clinical Endocrinology 2010
Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1β-induced neurotoxicity
EN McNamee, KM Ryan, D Kilroy, TJ Connor
European Journal of Pharmacology 2010
Serum anti-inflammatory markers in general population subjects with elevated depressive symptoms
SM Lehto, L Niskanen, J Miettola, T Tolmunen, H Viinamäki, P Mäntyselkä
Neuroscience Letters 2010
Abrogation of NF-κB signaling in human neutrophils induces neutrophil survival through sustained p38-MAPK activation
JD Langereis, HA Raaijmakers, LH Ulfman, L Koenderman
Journal of leukocyte biology 2010
Phosphoryl Moieties of Lipid A from Neisseria meningitidis and N. gonorrhoeae Lipooligosaccharides Play an Important Role in Activation of Both MyD88- and TRIF-Dependent TLR4–MD-2 Signaling Pathways
M Liu, CM John, GA Jarvis
Journal of immunology (Baltimore, Md. : 1950) 2010
Interleukin-1 receptor antagonist (IL-1Ra) and IL-1Ra producing mesenchymal stem cells as modulators of diabetogenesis
V Volarevic, A Al-Qahtani, N Arsenijevic, S Pajovic, ML Lukic
Autoimmunity 2009
The role of interleukins in insulin resistance and type 2 diabetes mellitus
B Fève, JP Bastard
Nature Reviews Endocrinology 2009
Increased plasma interleukin-1 receptor antagonist levels in men with visceral obesity
A Cartier, J Bergeron, P Poirier, N Alméras, A Tremblay, I Lemieux, JP Després
Annals of Medicine 2009
Interleukin-1 receptor antagonist and incident depressive symptoms over 6 years in older persons: the InCHIANTI study
Y Milaneschi, AM Corsi, BW Penninx, S Bandinelli, JM Guralnik, L Ferrucci
Biological Psychiatry 2009
TLR4-independent and PKR-dependent interleukin 1 receptor antagonist expression upon LPS stimulation
HY Na, K Mazumdar, HJ Moon, S Chang, SY Seong
Cellular Immunology 2009
Fatigue in primary Sjögren’s syndrome – A link to sickness behaviour in animals?
E Harboe, AB Tjensvoll, HK Vefring, LG Gøransson, JT Kvaløy, R Omdal
Brain, Behavior, and Immunity 2009
Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in men
N Andersson, L Strandberg, S Nilsson, Ö Ljungren, MK Karlsson, D Mellström, M Lorentzon, C Ohlsson, JO Jansson
International Journal of Obesity 2009
Initial description of the human NLRP3 promoter
JP Anderson, JL Mueller, A Misaghi, S Anderson, M Sivagnanam, RD Kolodner, HM Hoffman
Genes and Immunity 2008
C-reactive protein and systemic lupus erythematosus
S Gaitonde, D Samols, I Kushner
Arthritis & Rheumatism 2008
Changes in HLA-DR expression, cytokine production and coagulation following endotoxin infusion in healthy human volunteers
TG Mant, S Borozdenkova, DB Bradford, E Allen, DM Amin, RD Toothaker, RW Collins, RE Hargreaves, S Jurcevic
International Immunopharmacology 2008
Impaired counter-regulation of interleukin-1 by the soluble IL-1 receptor type II in patients with chronic liver disease
O Ludwiczek, E Vannier, A Moschen, A Salazar-Montes, I Borggraefe, C Gabay, B Enrich, A Kaser, B Siegmund, C Dinarello, H Tilg
Scandinavian Journal of Gastroenterology 2008
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
BK Pedersen, MA Febbraio
Physiological reviews 2008
Polymorphisms of the IL1-Receptor Antagonist Gene ( IL1RN ) Are Associated With Multiple Markers of Systemic Inflammation
AP Reiner, MM Wurfel, LA Lange, CS Carlson, AS Nord, CL Carty, MJ Rieder, C Desmarais, NS Jenny, C Iribarren, JD Walston, OD Williams, DA Nickerson, GP Jarvik
Arteriosclerosis, thrombosis, and vascular biology 2008
Role of ischaemic preconditioning in liver regeneration following major liver resection and transplantation
Gomez D, Homer-Vanniasinkam S, Graham A, Prasad K
World journal of gastroenterology : WJG 2007
In-hospital outcome of patients with acute coronary syndrome: relationship with inflammation and remodeling markers
C Giansante, N Fiotti, AD Chiara, N Altamura, S Wasserman, P Fioretti, G Guarnieri
Journal of Cardiovascular Medicine 2007
Serum levels of interleukin-1 receptor antagonist (IL-1ra) in thyroid cancer patients
S Niedźwiecki, T Stępień, K Kuzdak, H Stępień, R Krupiński, D Seehofer, N Rayes, F Ulrich
Langenbeck's Archives of Surgery 2007
Leptin induces interleukin-1β release from rat microglial cells through a caspase 1 independent mechanism
E Pinteaux, W Inoue, L Schmidt, F Molina-Holgado, NJ Rothwell, GN Luheshi
Journal of Neurochemistry 2007
Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels
S Rafiq, K Stevens, AJ Hurst, A Murray, W Henley, MN Weedon, S Bandinelli, AM Corsi, JM Guralnik, L Ferruci, D Melzer, TM Frayling
Genes and Immunity 2007
The Interleukin-1 receptor antagonist is a direct target gene of PPARα in liver
R Stienstra, S Mandard, NS Tan, W Wahli, C Trautwein, TA Richardson, E Lichtenauer-Kaligis, S Kersten, M Müller
Journal of Hepatology 2007
Sarcopenic obesity and inflammation in the InCHIANTI study
MA Schrager, EJ Metter, E Simonsick, A Ble, S Bandinelli, F Lauretani, L Ferrucci
Journal of applied physiology 2007
State of the Art Reviews: Health Benefits Related to Exercise in Patients With Chronic Low-Grade Systemic Inflammation
BK Pedersen
American journal of lifestyle medicine 2007
Interleukin-6 and chronic inflammation
C Gabay
Arthritis Research & Therapy 2006
Encyclopedia of Molecular Cell Biology and Molecular Medicine
E Beutler
Encyclopedia of Molecular Cell Biology and Molecular Medicine 2006
Interleukin-1 as a therapeutic target in acute brain injury
JR Selvarajah, A Parry-Jones, CJ McMahon, NJ Rothwell
Future Neurology 2006
IL-1BandIL-1RNgene polymorphisms in rheumatoid arthritis: relationship with protein plasma levels and response to therapy
B Tolusso, D Pietrapertosa, A Morelli, MD Santis, E Gremese, G Farina, SG Carniello, MD Frate, G Ferraccioli
Pharmacogenomics 2006
Most of the interleukin 1 receptor antagonist, cathepsin S, macrophage migration inhibitory factor, nerve growth factor, and interleukin 18 release by explants of human adipose tissue is by the non–fat cells, not by the adipocytes
JN Fain, DS Tichansky, AK Madan
Metabolism 2006
No response of plasma substance P, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress
N Rohleder, JM Wolf, I Herpfer, BL Fiebich, C Kirschbaum, K Lieb
Life Sciences 2006
Interleukin-1 receptor antagonist gene polymorphism affects the progression of chronic renal failure
M Buraczynska, P Ksiazek, P Kubit, W Zaluska
Cytokine 2006
IL-1 receptor antagonist in metabolic diseases: Dr Jekyll or Mr Hyde?
S Perrier, F Darakhshan, E Hajduch
FEBS Letters 2006
Polymorphisms of interleukin-1R receptor antagonist genes in patients with chronic hepatitis B in Iran
M Ranjbar, AH Alizadeh, M Hajiloi, SM Mousavi
World journal of gastroenterology : WJG 2006
Invited review: Compartmentalization of the inflammatory response in sepsis and SIRS
JM Cavaillon, D Annane
Journal of Endotoxin Research 2006
Interleukin-1 Receptor Antagonist Induction as an Additional Mechanism for Liver Receptor Homolog-1 to Negatively Regulate the Hepatic Acute Phase Response
N Venteclef, P Delerive
The Journal of biological chemistry 2006
Adipose Tissue Has Anti-Inflammatory Properties: Focus on IL-1 Receptor Antagonist (IL-1Ra)
JM Dayer
Annals of the New York Academy of Sciences 2006
Intracellular IL-1 receptor antagonist type 1 inhibits IL-1-induced cytokine production in keratinocytes through binding to the third component of the COP9 signalosome
NK Banda, C Guthridge, D Sheppard, KS Cairns, M Muggli, D Bech-Otschir, W Dubiel, WP Arend
Journal of immunology (Baltimore, Md. : 1950) 2005
Improved diagnostic approaches to infection/sepsis detection
BH Davis
Expert Review of Molecular Diagnostics 2005
Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1?-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor ?/?-dependent mechanism
D Moulin, A Bianchi, S Boyault, S Sebillaud, M Koufany, M Francois, P Netter, JY Jouzeau, B Terlain
Arthritis & Rheumatism 2005
The many worlds of reducing interleukin-1
CA Dinarello
Arthritis & Rheumatism 2005
Ischemic preconditioning modulates the expression of several genes, leading to the overproduction of IL-1Ra, iNOS, and Bcl-2 in a human model of liver ischemia-reperfusion
A Barrier, N Olaya, F Chiappini, F Roser, O Scatton, C Artus, B Franc, S Dudoit, A Flahault, B Debuire, D Azoulay, A Lemoine
The FASEB Journal 2005
The anti-inflammatory effect of exercise
AM Petersen, BK Pedersen
Journal of applied physiology 2005
CD14 is an acute-phase protein
S Bas, BR Gauthier, U Spenato, S Stingelin, C Gabay
Journal of immunology (Baltimore, Md. : 1950) 2004
The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes
G Palmer, D Burger, F Mezin, D Magne, C Gabay, JM Dayer, PA Guerne
Arthritis Research & Therapy 2004
Interferon beta stimulates interleukin 1 receptor antagonist production in human articular chondrocytes and synovial fibroblasts
G Palmer, F Mezin, CE Juge-Aubry, C Plater-Zyberk, C Gabay, PA Guerne
Annals of the rheumatic diseases 2004
Treatment with granulocyte colony-stimulating factor increases interleukin-1 receptor antagonist levels during engraftment following allogeneic stem-cell transplantation
M Schwabe, AM Hartert, H Bertz, J Finke
European Journal of Clinical Investigation 2004
L'influence du génotype dans la réponse inflammatoire
M M’Baku-Glöckel, PV Aka, M Kirsch-Volders
Nutrition Clinique et Métabolisme 2004
Polymorphisms of interleukin-1B and interleukin-1 receptor antagonist genes in patients with chronic hepatitis B
Ping-An Zhang, Yan Li, Pu Xu, Jian-Min Wu
World journal of gastroenterology : WJG 2004
Adaptation of the endothelium to fluid flow: in vitro analyses of gene expression and in vivo implications
SM Wasserman, JN Topper
Vascular medicine (London, England) 2004
Cytokines and Joint Injury
WB van den Berg, P Miossec
2004
Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response
MM Treggiari, GR Kleger, P Roux-Lombard, M Fathi, C Pichard, JA Romand, V Gozzoli
Intensive Care Medicine 2004
Serum Levels of Interleukin-1 Receptor Antagonist and Tumor Necrosis Factor-Alpha Are Elevated in Children With Langerhans Cell Histiocytosis
DA Rosso, MF Ripoli, A Roy, RA Diez, ME Zelazko, JL Braier
Journal of Pediatric Hematology/Oncology 2003
Leptin activates the promoter of the interleukin-1 receptor antagonist through p42/44 mitogen-activated protein kinase and a composite nuclear factor kappa B/PU.1 binding site
MG Dreyer, CE Juge-Aubry, C Gabay, U Lang, F Rohner-Jeanrenaud, JM Dayer, CA Meier
Biochemical Journal 2003
Cortisol responses to mild psychological stress are inversely associated with proinflammatory cytokines
SR Kunz-Ebrecht, V Mohamed-Ali, PJ Feldman, C Kirschbaum, A Steptoe
Brain, Behavior, and Immunity 2003
Effects of glossopharyngeal nerve transection on central and peripheral cytokines and serum corticosterone induced by localized inflammation
HE Romeo, DL Tio, AN Taylor
Journal of Neuroimmunology 2003
Critical care of the obese and bariatric surgical patient
D Levi, ER Goodman, M Patel, Y Savransky
Critical Care Clinics 2003
The role of interleukin-1 receptor antagonist in the prevention and treatment of disease
WP Arend
Modern Rheumatology 2003
Corticosteroids in Sepsis: From Bench to Bedside?:
D Annane, JM Cavaillon
Shock 2003
Immunomodulatory actions of leptin
CE Juge-Aubry, CA Meier
Molecular and Cellular Endocrinology 2002
Anti-interleukin 1alpha autoantibodies
P Miossec
Annals of the rheumatic diseases 2002
Leptin induces IL-1 receptor antagonist expression in the brain
T Hosoi, Y Okuma, Y Nomura
Biochemical and Biophysical Research Communications 2002
IL-8 and TNF-alpha from peripheral neutrophils and acute-phase proteins in periodontitis. Effect of cigarette smoking: a pilot study
M Fredriksson, K Bergstrom, B Asman
Journal of Clinical Periodontology 2002
Inflammatory cytokines, socioeconomic status, and acute stress responsivity
A Steptoe, N Owen, S Kunz-Ebrecht, V Mohamed-Ali
Brain, Behavior, and Immunity 2002
Microglia as a source and target of cytokines
UK Hanisch
Glia 2002
The balance between IL-1 and IL-1Ra in disease
William P Arend
Cytokine & Growth Factor Reviews 2002
Inflammatory markers and coronary interventions: A potentially useful follow-up modality after stenting
G Patti, GD Sciascio, A D'Ambrosio, G Dicuonzo, A Abbate, A Dobrina
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2002
Analysis of Host Response to Hepatectomy by Simultaneous Measurement of Cytokines in the Portal Vein, Caval Vein and Radial Artery
Y Kanaoka, T Yagi, H Sadamori, H Matsukawa, H Matsuda, M Inagaki, T Ishikawa, S Saito, H Iwagaki, N Tanaka
J INT MED RES 2002
Intra-tumoral interleukin-6 down-regulation system and genetic mutations of tumor suppressor genes in colorectal carcinoma
C Miki, H Tonouchi, R Wakuda, T Hatada, Y Inoue, E Minato, M Kobayashi, M Kusunoki
Cancer 2002
The Sepsis Text
JL Vincent, J Carlet, SM Opal
2002
Microglia in the Regenerating and Degenerating Central Nervous System
WJ Streit
2002
Production of interleukin-1 receptor antagonist by human articular chondrocytes
G Palmer, PA Guerne, F Mezin, M Maret, J Guicheux, MB Goldring, C Gabay
Arthritis Research & Therapy 2002
Candidate Genes as Potential Links Between Periodontal and Cardiovascular Diseases
KS Kornman, GW Duff
Annals of Periodontology 2001
Continuous Venovenous Hemofiltration Improves Arterial Oxygenation in Endotoxin-induced Lung Injury in Pigs
R Ullrich, G Roeder, C Lorber, ZM Quezado, W Kneifel, H Gasser, G Schlag, H Redl, P Germann
Anesthesiology 2001
In vivo effect of snake phospholipase A2 (crotoxin+cardiotoxin) on serum IL-1α, TNF-α and IL-1ra level in humans
LA Costa, MC Fornari, VE Berardi, HA Miles, RA Diez
Immunology Letters 2001
Production of IL-1 receptor antagonist by hepatocytes is regulated as an acute-phase proteinin vivo
C Gabay, J Gigley, J Sipe, WP Arend, G Fantuzzi
European Journal of Immunology 2001
Identification of a Novel Human Cytokine Gene in the Interleukin Gene Cluster on Chromosome 2q12-14
JT Bensen, PA Dawson, JC Mychaleckyj, DW Bowden
Journal of Interferon & Cytokine Research 2001
Role of endogenous interleukin-1 receptor antagonist in regulating fever induced by localised inflammation in the rat
T Cartmell, GN Luheshi, SJ Hopkins, NJ Rothwell, S Poole
The Journal of Physiology 2001
ROLE OF IL-18 IN THE SECRETION OF IL-1β, sIL-1RII, AND IL-1Ra BY HUMAN NEUTROPHILS
E Jablonska, E Jablonska, A Iżycka, J Jablonski, N Wawrusiewicz, J Piecuch
Immunological Investigations 2001
IL-1B and IL-1Ra gene polymorphisms and disease severity in rheumatoid arthritis: interaction with their plasma levels
N Buchs, FS di Giovine, T Silvestri, E Vannier, GW Duff, P Miossec
Genes and Immunity 2001
Phylogenetic Perspectives on the Vertebrate Immune System
G Beck, M Sugumaran, EL Cooper
2001
IL-1 inhibitors: novel agents in the treatment of rheumatoid arthritis
C Gabay
Expert Opinion on Investigational Drugs 2000
Arterial Inflammation in Mice Lacking the Interleukin 1 Receptor Antagonist Gene
MJ Nicklin, DE Hughes, JL Barton, JM Ure, GW Duff
Journal of Experimental Medicine 2000
Biological role of interleukin 1 receptor antagonist isoforms
WP Arend, CJ Guthridge
Annals of the rheumatic diseases 2000
Physiologic role of interleukin-1 receptor antagonist
WP Arend, C Gabay
Arthritis research 2000
Defective interleukin-1 receptor antagonist production is associated with resistance of acute liver graft rejection to steroid therapy
F Conti, S Breton, F Batteux, V Furlan, D Houssin, B Weill, Y Calmus
The American Journal of Pathology 2000
Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene
MJ Nicklin, DE Hughes, JL Barton, JM Ure, GW Duff
Journal of Experimental Medicine 2000
Interleukin-1 receptor antagonist in ascites indicates acute graft rejection after pediatric liver transplantation
R Ganschow, B Baade, HH Hellwege, DC Broering, X Rogiers, M Burdelski
Pediatric Transplantation 2000
Rôle des glucocorticoïdes dans la cascade inflammatoire
JM Cavaillon
Réanimation Urgences 2000
Macrophages as an effector mechanism to reject encapsulated hepatoma cells
SC Yu, JP Chen, HS Liu, BR Hsu, SH Fu
Transplantation Proceedings 2000
Cytokine-mediated, deteriorative effects of brain death on porcine liver transplantation: intervention of sympathoadrenal pathway in cerebrohepatic organ interaction
A Endo, T Yagi, A Nakao, H Matsukawa, Y Okada, H Iwagaki, N Tanaka
Transplantation Proceedings 2000
Interleukin-1 receptor antagonist production during infectious and noninfectious systemic inflammatory response syndrome
C Marie, J Muret, C Fitting, D Payen, J M Cavaillon
Critical Care Medicine 2000
Interleukin-1 Receptor Antagonist Expression in Human Endothelial Cells and Atherosclerosis
R Dewberry, H Holden, D Crossman, S Francis
Arteriosclerosis, thrombosis, and vascular biology 2000
Multiple Organ Failure
AE Baue, E Faist, DE Fry
2000
Immune Response in the Critically Ill
JC Marshall, J Cohen
2000
ATP Acts as an Agonist to Promote Stimulus-Induced Secretion of IL-1β and IL-18 in Human Blood
DG Perregaux, P McNiff, R Laliberte, M Conklyn, CA Gabel
Journal of immunology (Baltimore, Md. : 1950) 2000
The concept of glomerular self-defense
M Kitamura, LG Fine
Kidney International 1999
Peptidomimetic fluoromethylketone rescues mice from lethal endotoxic shock
SR Grobmyer, RC Armstrong, SC Nicholson, C Gabay, WP Arend, SH Potter, M Melchior, LC Fritz, CF Nathan
Molecular Medicine 1999
Dynamic regulation of the proinflammatory cytokine, interleukin-1β: Molecular biology for non-molecular biologists
LR Watkins, MK Hansen, KT Nguyen, JE Lee, SF Maier
Life Sciences 1999
Atherosclerosis and inflammation. Patterns of cytokine regulation in patients with peripheral arterial disease
N Fiotti, C Giansante, E Ponte, C Delbello, S Calabrese, T Zacchi, A Dobrina, G Guarnieri
Atherosclerosis 1999
THE HUMAN INTRACELLULAR INTERLEUKIN 1 RECEPTOR ANTAGONIST PROMOTER APPROPRIATELY REGULATES GENE EXPRESSION IN KERATINOCYTES AND GASTROINTESTINAL EPITHELIAL CELLS IN VIVO
C Gabay, MF Smith, WP Arend
Cytokine 1999
Acute-Phase Proteins and Other Systemic Responses to Inflammation
FH Epstein, C Gabay, I Kushner
New England Journal of Medicine 1999
IL-1ra administration does not improve cardiac function in patients with severe sepsis
JL Vincent, G Slotman, PA van Leeuwen, M Shelly, S Nasraway, A Tenaillon, J Bander, G Friedman
Journal of Critical Care 1999
Circulating Postinjury Neutrophils Are Primed for the Release of Proinflammatory Cytokines:
G Zallen, EE Moore, JL Johnson, DY Tamura, J Aiboshi, WL Biffl, CC Silliman
The Journal of Trauma: Injury, Infection and Critical Care 1999
Sepsis and Organ Dysfunction
AE Baue, G Berlot, A Gullo, JL Vincent
1999
Increasing Levels of Interleukin (IL)-1Ra and IL-6 During the First 2 Days of Hospitalization in Unstable Angina Are Associated With Increased Risk of In-Hospital Coronary Events
LM Biasucci, G Liuzzo, G Fantuzzi, G Caligiuri, AG Rebuzzi, F Ginnetti, CA Dinarello, A Maseri
Circulation 1999
Cytokines, Stress, and Depression
R Dantzer, EE Wollman, R Yirmiya
1999
Interleukin-4 (IL-4) and IL-13 Enhance the Effect of IL-1β on Production of IL-1 Receptor Antagonist by Human Primary Hepatocytes and Hepatoma HepG2 Cells: Differential Effect on C-Reactive Protein Production
C Gabay, B Porter, D Guenette, B Billir, WP Arend
Blood 1999
Differential expression of interleukin 1 receptor antagonist isoforms in human intestinal epithelial cells
U Böcker, A Damião, L Holt, DS Han, C Jobin, A Panja, L Mayer, RB Sartor
Gastroenterology 1998
INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology
WP Arend, M Malyak, CJ Guthridge, C Gabay
Annual Review of Immunology 1998
HIV infection and malnutrition
A Schwenk
Current Opinion in Clinical Nutrition and Metabolic Care 1998
Regulation of serum amyloid A protein expression during the acute-phase response
LE Jensen, AS Whitehead
Biochemical Journal 1998
Relationship between Interleukin-1 and Interleukin-1 Receptor Antagonist during the Development of Fever in the Rata
T Cartmell, S Poole, NJ Rothwell, GN Luheshi
Annals of the New York Academy of Sciences 1998
Detection of an Interleukin-1 Intracellular Receptor Antagonist mRNA Variant
L Weissbach, K Tran, SA Colquhoun, MF Champliaud, CA Towle
Biochemical and Biophysical Research Communications 1998
Elevated levels of soluble interleukin-1 receptor type II and interleukin-1 receptor antagonist in patients with chronic arthritis: Correlations with markers of inflammation and joint destruction
P Jouvenne, E Vannier, CA Dinarello, P Miossec
Arthritis & Rheumatism 1998
Increased circulating cytokine receptors and ex vivo interleukin-1 receptor antagonist and interleukin-1beta production but decreased tumour necrosis factor-alpha production after a 5-km run
Drenth, Krebbers, Bijzet, van der Meer
European Journal of Clinical Investigation 1998
Prostaglandin-Independent Stimulation of Interleukin-6 Production by Fibrinogen Degradation Product D in Perfused Murine Liver
Csala, Lerant, Banhegyi, Kardon, Puskas, Mucha, Machovich, Falus, Mandl
Scandinavian Journal of Immunology 1998
Semantics, Inflammation, Cytokines and Common Sense
I Kushner
Cytokine & Growth Factor Reviews 1998
Kainic acid induced expression of interleukin-1 receptor antagonist mRNA in the rat brain
C Eriksson, B Winblad, M Schultzberg
Molecular Brain Research 1998
Interleukin (IL)-6 and Its Soluble Receptor Induce TIMP-1 Expression in Synoviocytes and Chondrocytes, and Block IL-1-induced Collagenolytic Activity
P Silacci, JM Dayer, A Desgeorges, R Peter, C Manueddu, PA Guerne
The Journal of biological chemistry 1998
Secretory Interleukin-1 Receptor Antagonist Gene Expression Requires both a PU.1 and a Novel Composite NF-κB/PU.1/ GA-binding Protein Binding Site
MF Smith, VS Carl, T Lodie, MJ Fenton
The Journal of biological chemistry 1998
DOES INCREASED URINARY INTERLEUKIN-1 RECEPTOR ANTAGONIST/INTERLEUKIN-1?? RATIO INDICATE GOOD PROGNOSIS IN RENAL TRANSPLANT RECIPIENTS?:
AM Teppo, E Honkanen, J Ahonen, C Gronhagen-Riska
Transplantation 1998
Treatment of rheumatoid arthritis with IL-1 inhibitors
C Gabay, WP Arend
Springer Seminars in Immunopathology 1998
Role of pro-inflammatory cytokines in rheumatoid arthritis
FM Brennan, RN Maini, M Feldmann
Springer Seminars in Immunopathology 1998
Rheumatology
RA Asherson, R Cervera, DP D'Cruz, GR Hughes
Postgraduate medical journal 1991
International Review of Cytology
RA Miller
International Review of Cytology 1991

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