Interleukin 1 receptor antagonist (IL-1Ra) levels are elevated in the blood of patients with a variety of infectious, immune, or traumatic conditions. To examine whether IL1Ra is produced by liver cells with characteristics resembling an acute-phase protein, human primary hepatocytes isolated from liver biopsies and HepG2 hepatoma cells were stimulated with IL-1beta, IL-6, and TNFalpha. IL-1Ra was present in the supernatants of both cells, with production significantly enhanced by IL-1beta, and by the combination of IL-1beta and IL-6. The term IL-1Ra refers to two different proteins encoded by the same gene, but generated by alternative splicing of two different first exons. One isoform is secreted (17-kD sIL-1Ra), and the other isoform remains in the cytoplasm (18-kD icIL-1Ra). By Western blot analysis, the supernatants of human hepatoma (HepG2) cells contained only sIL-1Ra, whereas the lysates contained a novel smaller molecular mass isoform of 16 kD. RT-PCR and ribonuclease protection assay with RNA from HepG2 cells showed that only sIL-1Ra mRNA was expressed, and confirmed the inducing effect of IL-1beta and IL-6. Transfection studies were performed using constructs containing the promoters of either sIL-1Ra or icIL-1Ra coupled to the luciferase reporter gene. The sIL-1Ra promoter was active in HepG2 cells stimulated by IL-1beta and/or IL-6, whereas the icIL-1Ra promoter was inactive. Mutation of binding sites for transcription factors NF-kappaB and/or C/EBP within the proximal sIL-1Ra promoter led to significant decreases in response to IL-1beta and IL-6 in comparison to the wild-type promoter. Electromobility gel shift assays confirmed the presence of NF-kappaB and C/EBP binding sites within the sIL-1Ra promoter, and indicated a significant increase in the binding activities of nuclear proteins from HepG2 cells treated with IL-1beta and IL-6. In summary, sIL-1Ra, but not icIL-1Ra, is produced by hepatocytes, and is regulated by proinflammatory cytokines as an acute-phase protein. In addition, NF-kappaB and C/EBP family members are likely to play important roles in the full expression of IL-1Ra by hepatocytes during inflammatory conditions.
C Gabay, M F Smith, D Eidlen, W P Arend
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The protective role of vitamin C against linezolid-induced hepato-renal toxicity in a rat model
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Frontiers in Pharmacology | 2025 |
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Understanding Ocular Surface Inflammation in Tears Before and After Autologous Cultivated Limbal Epithelial Stem Cell Transplantation.
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Serum Levels of IL-1 RA Increase with Obesity and Type 2 Diabetes in Relation to Adipose Tissue Dysfunction and are Reduced After Bariatric Surgery in Parallel to Adiposity
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IL-1 Family Antagonists in Mouse and Human Skin Inflammation
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Regulation of IL-1 Receptor Antagonist by TSH in Fibrocytes and Orbital Fibroblasts
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The Journal of clinical endocrinology and metabolism | 2014 |
The Multifaceted Effects of Polysaccharides Isolated from Dendrobium huoshanense on Immune Functions with the Induction of Interleukin-1 Receptor Antagonist (IL-1ra) in Monocytes
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Korean Journal of Veterinary Research | 2013 |
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Journal of the Korean Surgical Society | 2012 |
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Encyclopedia of Life Sciences | 2011 |
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CCAAT/Enhancer-binding Protein β Inhibits Proliferation in Monocytic Cells by Affecting the Retinoblastoma Protein/E2F/Cyclin E Pathway but Is Not Directly Required for Macrophage Morphology
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2011 | |
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Sexual Dimorphism on Cytokines Expression in the Temporomandibular Joint: The Role of Gonadal Steroid Hormones
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Why not treat human cancer with interleukin-1 blockade?
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Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1β-induced neurotoxicity
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Serum anti-inflammatory markers in general population subjects with elevated depressive symptoms
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Nature Reviews Endocrinology | 2009 |
Increased plasma interleukin-1 receptor antagonist levels in men with visceral obesity
A Cartier, J Bergeron, P Poirier, N Alméras, A Tremblay, I Lemieux, JP Després |
Annals of Medicine | 2009 |
Interleukin-1 receptor antagonist and incident depressive symptoms over 6 years in older persons: the InCHIANTI study
Y Milaneschi, AM Corsi, BW Penninx, S Bandinelli, JM Guralnik, L Ferrucci |
Biological Psychiatry | 2009 |
TLR4-independent and PKR-dependent interleukin 1 receptor antagonist expression upon LPS stimulation
HY Na, K Mazumdar, HJ Moon, S Chang, SY Seong |
Cellular Immunology | 2009 |
Fatigue in primary Sjögren’s syndrome – A link to sickness behaviour in animals?
E Harboe, AB Tjensvoll, HK Vefring, LG Gøransson, JT Kvaløy, R Omdal |
Brain, Behavior, and Immunity | 2009 |
Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in men
N Andersson, L Strandberg, S Nilsson, Ö Ljungren, MK Karlsson, D Mellström, M Lorentzon, C Ohlsson, JO Jansson |
International Journal of Obesity | 2009 |
Initial description of the human NLRP3 promoter
JP Anderson, JL Mueller, A Misaghi, S Anderson, M Sivagnanam, RD Kolodner, HM Hoffman |
Genes and Immunity | 2008 |
C-reactive protein and systemic lupus erythematosus
S Gaitonde, D Samols, I Kushner |
Arthritis & Rheumatism | 2008 |
Changes in HLA-DR expression, cytokine production and coagulation following endotoxin infusion in healthy human volunteers
TG Mant, S Borozdenkova, DB Bradford, E Allen, DM Amin, RD Toothaker, RW Collins, RE Hargreaves, S Jurcevic |
International Immunopharmacology | 2008 |
Impaired counter-regulation of interleukin-1 by the soluble IL-1 receptor type II in patients with chronic liver disease
O Ludwiczek, E Vannier, A Moschen, A Salazar-Montes, I Borggraefe, C Gabay, B Enrich, A Kaser, B Siegmund, C Dinarello, H Tilg |
Scandinavian Journal of Gastroenterology | 2008 |
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
BK Pedersen, MA Febbraio |
Physiological reviews | 2008 |
Polymorphisms of the IL1-Receptor Antagonist Gene ( IL1RN ) Are Associated With Multiple Markers of Systemic Inflammation
AP Reiner, MM Wurfel, LA Lange, CS Carlson, AS Nord, CL Carty, MJ Rieder, C Desmarais, NS Jenny, C Iribarren, JD Walston, OD Williams, DA Nickerson, GP Jarvik |
Arteriosclerosis, thrombosis, and vascular biology | 2008 |
Role of ischaemic preconditioning in liver regeneration following major liver resection and transplantation
Gomez D, Homer-Vanniasinkam S, Graham A, Prasad K |
World journal of gastroenterology : WJG | 2007 |
In-hospital outcome of patients with acute coronary syndrome: relationship with inflammation and remodeling markers
C Giansante, N Fiotti, AD Chiara, N Altamura, S Wasserman, P Fioretti, G Guarnieri |
Journal of Cardiovascular Medicine | 2007 |
Serum levels of interleukin-1 receptor antagonist (IL-1ra) in thyroid cancer patients
S Niedźwiecki, T Stępień, K Kuzdak, H Stępień, R Krupiński, D Seehofer, N Rayes, F Ulrich |
Langenbeck's Archives of Surgery | 2007 |
Leptin induces interleukin-1β release from rat microglial cells through a caspase 1 independent mechanism
E Pinteaux, W Inoue, L Schmidt, F Molina-Holgado, NJ Rothwell, GN Luheshi |
Journal of Neurochemistry | 2007 |
Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels
S Rafiq, K Stevens, AJ Hurst, A Murray, W Henley, MN Weedon, S Bandinelli, AM Corsi, JM Guralnik, L Ferruci, D Melzer, TM Frayling |
Genes and Immunity | 2007 |
The Interleukin-1 receptor antagonist is a direct target gene of PPARα in liver
R Stienstra, S Mandard, NS Tan, W Wahli, C Trautwein, TA Richardson, E Lichtenauer-Kaligis, S Kersten, M Müller |
Journal of Hepatology | 2007 |
Sarcopenic obesity and inflammation in the InCHIANTI study
MA Schrager, EJ Metter, E Simonsick, A Ble, S Bandinelli, F Lauretani, L Ferrucci |
Journal of applied physiology | 2007 |
State of the Art Reviews: Health Benefits Related to Exercise in Patients With Chronic Low-Grade Systemic Inflammation
BK Pedersen |
American journal of lifestyle medicine | 2007 |
Interleukin-6 and chronic inflammation
C Gabay |
Arthritis Research & Therapy | 2006 |
Encyclopedia of Molecular Cell Biology and Molecular Medicine
E Beutler |
Encyclopedia of Molecular Cell Biology and Molecular Medicine | 2006 |
Interleukin-1 as a therapeutic target in acute brain injury
JR Selvarajah, A Parry-Jones, CJ McMahon, NJ Rothwell |
Future Neurology | 2006 |
IL-1BandIL-1RNgene polymorphisms in rheumatoid arthritis: relationship with protein plasma levels and response to therapy
B Tolusso, D Pietrapertosa, A Morelli, MD Santis, E Gremese, G Farina, SG Carniello, MD Frate, G Ferraccioli |
Pharmacogenomics | 2006 |
Most of the interleukin 1 receptor antagonist, cathepsin S, macrophage migration inhibitory factor, nerve growth factor, and interleukin 18 release by explants of human adipose tissue is by the non–fat cells, not by the adipocytes
JN Fain, DS Tichansky, AK Madan |
Metabolism | 2006 |
No response of plasma substance P, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress
N Rohleder, JM Wolf, I Herpfer, BL Fiebich, C Kirschbaum, K Lieb |
Life Sciences | 2006 |
Interleukin-1 receptor antagonist gene polymorphism affects the progression of chronic renal failure
M Buraczynska, P Ksiazek, P Kubit, W Zaluska |
Cytokine | 2006 |
IL-1 receptor antagonist in metabolic diseases: Dr Jekyll or Mr Hyde?
S Perrier, F Darakhshan, E Hajduch |
FEBS Letters | 2006 |
Polymorphisms of interleukin-1R receptor antagonist genes in patients with chronic hepatitis B in Iran
M Ranjbar, AH Alizadeh, M Hajiloi, SM Mousavi |
World journal of gastroenterology : WJG | 2006 |
Invited review: Compartmentalization of the inflammatory response in sepsis and SIRS
JM Cavaillon, D Annane |
Journal of Endotoxin Research | 2006 |
Interleukin-1 Receptor Antagonist Induction as an Additional Mechanism for Liver Receptor Homolog-1 to Negatively Regulate the Hepatic Acute Phase Response
N Venteclef, P Delerive |
The Journal of biological chemistry | 2006 |
Adipose Tissue Has Anti-Inflammatory Properties: Focus on IL-1 Receptor Antagonist (IL-1Ra)
JM Dayer |
Annals of the New York Academy of Sciences | 2006 |
Intracellular IL-1 receptor antagonist type 1 inhibits IL-1-induced cytokine production in keratinocytes through binding to the third component of the COP9 signalosome
NK Banda, C Guthridge, D Sheppard, KS Cairns, M Muggli, D Bech-Otschir, W Dubiel, WP Arend |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
Improved diagnostic approaches to infection/sepsis detection
BH Davis |
Expert Review of Molecular Diagnostics | 2005 |
Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1?-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor ?/?-dependent mechanism
D Moulin, A Bianchi, S Boyault, S Sebillaud, M Koufany, M Francois, P Netter, JY Jouzeau, B Terlain |
Arthritis & Rheumatism | 2005 |
The many worlds of reducing interleukin-1
CA Dinarello |
Arthritis & Rheumatism | 2005 |
Ischemic preconditioning modulates the expression of several genes, leading to the overproduction of IL-1Ra, iNOS, and Bcl-2 in a human model of liver ischemia-reperfusion
A Barrier, N Olaya, F Chiappini, F Roser, O Scatton, C Artus, B Franc, S Dudoit, A Flahault, B Debuire, D Azoulay, A Lemoine |
The FASEB Journal | 2005 |
The anti-inflammatory effect of exercise
AM Petersen, BK Pedersen |
Journal of applied physiology | 2005 |
CD14 is an acute-phase protein
S Bas, BR Gauthier, U Spenato, S Stingelin, C Gabay |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes
G Palmer, D Burger, F Mezin, D Magne, C Gabay, JM Dayer, PA Guerne |
Arthritis Research & Therapy | 2004 |
Interferon beta stimulates interleukin 1 receptor antagonist production in human articular chondrocytes and synovial fibroblasts
G Palmer, F Mezin, CE Juge-Aubry, C Plater-Zyberk, C Gabay, PA Guerne |
Annals of the rheumatic diseases | 2004 |
Treatment with granulocyte colony-stimulating factor increases interleukin-1 receptor antagonist levels during engraftment following allogeneic stem-cell transplantation
M Schwabe, AM Hartert, H Bertz, J Finke |
European Journal of Clinical Investigation | 2004 |
L'influence du génotype dans la réponse inflammatoire
M M’Baku-Glöckel, PV Aka, M Kirsch-Volders |
Nutrition Clinique et Métabolisme | 2004 |
Polymorphisms of interleukin-1B and interleukin-1 receptor antagonist genes in patients with chronic hepatitis B
Ping-An Zhang, Yan Li, Pu Xu, Jian-Min Wu |
World journal of gastroenterology : WJG | 2004 |
Adaptation of the endothelium to fluid flow: in vitro analyses of gene expression and in vivo implications
SM Wasserman, JN Topper |
Vascular medicine (London, England) | 2004 |
Cytokines and Joint Injury
WB van den Berg, P Miossec |
2004 | |
Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response
MM Treggiari, GR Kleger, P Roux-Lombard, M Fathi, C Pichard, JA Romand, V Gozzoli |
Intensive Care Medicine | 2004 |
Serum Levels of Interleukin-1 Receptor Antagonist and Tumor Necrosis Factor-Alpha Are Elevated in Children With Langerhans Cell Histiocytosis
DA Rosso, MF Ripoli, A Roy, RA Diez, ME Zelazko, JL Braier |
Journal of Pediatric Hematology/Oncology | 2003 |
Leptin activates the promoter of the interleukin-1 receptor antagonist through p42/44 mitogen-activated protein kinase and a composite nuclear factor kappa B/PU.1 binding site
MG Dreyer, CE Juge-Aubry, C Gabay, U Lang, F Rohner-Jeanrenaud, JM Dayer, CA Meier |
Biochemical Journal | 2003 |
Cortisol responses to mild psychological stress are inversely associated with proinflammatory cytokines
SR Kunz-Ebrecht, V Mohamed-Ali, PJ Feldman, C Kirschbaum, A Steptoe |
Brain, Behavior, and Immunity | 2003 |
Effects of glossopharyngeal nerve transection on central and peripheral cytokines and serum corticosterone induced by localized inflammation
HE Romeo, DL Tio, AN Taylor |
Journal of Neuroimmunology | 2003 |
Critical care of the obese and bariatric surgical patient
D Levi, ER Goodman, M Patel, Y Savransky |
Critical Care Clinics | 2003 |
The role of interleukin-1 receptor antagonist in the prevention and treatment of disease
WP Arend |
Modern Rheumatology | 2003 |
Corticosteroids in Sepsis: From Bench to Bedside?:
D Annane, JM Cavaillon |
Shock | 2003 |
Immunomodulatory actions of leptin
CE Juge-Aubry, CA Meier |
Molecular and Cellular Endocrinology | 2002 |
Anti-interleukin 1alpha autoantibodies
P Miossec |
Annals of the rheumatic diseases | 2002 |
Leptin induces IL-1 receptor antagonist expression in the brain
T Hosoi, Y Okuma, Y Nomura |
Biochemical and Biophysical Research Communications | 2002 |
IL-8 and TNF-alpha from peripheral neutrophils and acute-phase proteins in periodontitis. Effect of cigarette smoking: a pilot study
M Fredriksson, K Bergstrom, B Asman |
Journal of Clinical Periodontology | 2002 |
Inflammatory cytokines, socioeconomic status, and acute stress responsivity
A Steptoe, N Owen, S Kunz-Ebrecht, V Mohamed-Ali |
Brain, Behavior, and Immunity | 2002 |
Microglia as a source and target of cytokines
UK Hanisch |
Glia | 2002 |
The balance between IL-1 and IL-1Ra in disease
William P Arend |
Cytokine & Growth Factor Reviews | 2002 |
Inflammatory markers and coronary interventions: A potentially useful follow-up modality after stenting
G Patti, GD Sciascio, A D'Ambrosio, G Dicuonzo, A Abbate, A Dobrina |
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions | 2002 |
Analysis of Host Response to Hepatectomy by Simultaneous Measurement of Cytokines in the Portal Vein, Caval Vein and Radial Artery
Y Kanaoka, T Yagi, H Sadamori, H Matsukawa, H Matsuda, M Inagaki, T Ishikawa, S Saito, H Iwagaki, N Tanaka |
J INT MED RES | 2002 |
Intra-tumoral interleukin-6 down-regulation system and genetic mutations of tumor suppressor genes in colorectal carcinoma
C Miki, H Tonouchi, R Wakuda, T Hatada, Y Inoue, E Minato, M Kobayashi, M Kusunoki |
Cancer | 2002 |
The Sepsis Text
JL Vincent, J Carlet, SM Opal |
2002 | |
Microglia in the Regenerating and Degenerating Central Nervous System
WJ Streit |
2002 | |
Production of interleukin-1 receptor antagonist by human articular chondrocytes
G Palmer, PA Guerne, F Mezin, M Maret, J Guicheux, MB Goldring, C Gabay |
Arthritis Research & Therapy | 2002 |
Candidate Genes as Potential Links Between Periodontal and Cardiovascular Diseases
KS Kornman, GW Duff |
Annals of Periodontology | 2001 |
Continuous Venovenous Hemofiltration Improves Arterial Oxygenation in Endotoxin-induced Lung Injury in Pigs
R Ullrich, G Roeder, C Lorber, ZM Quezado, W Kneifel, H Gasser, G Schlag, H Redl, P Germann |
Anesthesiology | 2001 |
In vivo effect of snake phospholipase A2 (crotoxin+cardiotoxin) on serum IL-1α, TNF-α and IL-1ra level in humans
LA Costa, MC Fornari, VE Berardi, HA Miles, RA Diez |
Immunology Letters | 2001 |
Production of IL-1 receptor antagonist by hepatocytes is regulated as an acute-phase proteinin vivo
C Gabay, J Gigley, J Sipe, WP Arend, G Fantuzzi |
European Journal of Immunology | 2001 |
Identification of a Novel Human Cytokine Gene in the Interleukin Gene Cluster on Chromosome 2q12-14
JT Bensen, PA Dawson, JC Mychaleckyj, DW Bowden |
Journal of Interferon & Cytokine Research | 2001 |
Role of endogenous interleukin-1 receptor antagonist in regulating fever induced by localised inflammation in the rat
T Cartmell, GN Luheshi, SJ Hopkins, NJ Rothwell, S Poole |
The Journal of Physiology | 2001 |
ROLE OF IL-18 IN THE SECRETION OF IL-1β, sIL-1RII, AND IL-1Ra BY HUMAN NEUTROPHILS
E Jablonska, E Jablonska, A Iżycka, J Jablonski, N Wawrusiewicz, J Piecuch |
Immunological Investigations | 2001 |
IL-1B and IL-1Ra gene polymorphisms and disease severity in rheumatoid arthritis: interaction with their plasma levels
N Buchs, FS di Giovine, T Silvestri, E Vannier, GW Duff, P Miossec |
Genes and Immunity | 2001 |
Phylogenetic Perspectives on the Vertebrate Immune System
G Beck, M Sugumaran, EL Cooper |
2001 | |
IL-1 inhibitors: novel agents in the treatment of rheumatoid arthritis
C Gabay |
Expert Opinion on Investigational Drugs | 2000 |
Arterial Inflammation in Mice Lacking the Interleukin 1 Receptor Antagonist Gene
MJ Nicklin, DE Hughes, JL Barton, JM Ure, GW Duff |
Journal of Experimental Medicine | 2000 |
Biological role of interleukin 1 receptor antagonist isoforms
WP Arend, CJ Guthridge |
Annals of the rheumatic diseases | 2000 |
Physiologic role of interleukin-1 receptor antagonist
WP Arend, C Gabay |
Arthritis research | 2000 |
Defective interleukin-1 receptor antagonist production is associated with resistance of acute liver graft rejection to steroid therapy
F Conti, S Breton, F Batteux, V Furlan, D Houssin, B Weill, Y Calmus |
The American Journal of Pathology | 2000 |
Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene
MJ Nicklin, DE Hughes, JL Barton, JM Ure, GW Duff |
Journal of Experimental Medicine | 2000 |
Interleukin-1 receptor antagonist in ascites indicates acute graft rejection after pediatric liver transplantation
R Ganschow, B Baade, HH Hellwege, DC Broering, X Rogiers, M Burdelski |
Pediatric Transplantation | 2000 |
Rôle des glucocorticoïdes dans la cascade inflammatoire
JM Cavaillon |
Réanimation Urgences | 2000 |
Macrophages as an effector mechanism to reject encapsulated hepatoma cells
SC Yu, JP Chen, HS Liu, BR Hsu, SH Fu |
Transplantation Proceedings | 2000 |
Cytokine-mediated, deteriorative effects of brain death on porcine liver transplantation: intervention of sympathoadrenal pathway in cerebrohepatic organ interaction
A Endo, T Yagi, A Nakao, H Matsukawa, Y Okada, H Iwagaki, N Tanaka |
Transplantation Proceedings | 2000 |
Interleukin-1 receptor antagonist production during infectious and noninfectious systemic inflammatory response syndrome
C Marie, J Muret, C Fitting, D Payen, J M Cavaillon |
Critical Care Medicine | 2000 |
Interleukin-1 Receptor Antagonist Expression in Human Endothelial Cells and Atherosclerosis
R Dewberry, H Holden, D Crossman, S Francis |
Arteriosclerosis, thrombosis, and vascular biology | 2000 |
Multiple Organ Failure
AE Baue, E Faist, DE Fry |
2000 | |
Immune Response in the Critically Ill
JC Marshall, J Cohen |
2000 | |
ATP Acts as an Agonist to Promote Stimulus-Induced Secretion of IL-1β and IL-18 in Human Blood
DG Perregaux, P McNiff, R Laliberte, M Conklyn, CA Gabel |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
The concept of glomerular self-defense
M Kitamura, LG Fine |
Kidney International | 1999 |
Peptidomimetic fluoromethylketone rescues mice from lethal endotoxic shock
SR Grobmyer, RC Armstrong, SC Nicholson, C Gabay, WP Arend, SH Potter, M Melchior, LC Fritz, CF Nathan |
Molecular Medicine | 1999 |
Dynamic regulation of the proinflammatory cytokine, interleukin-1β: Molecular biology for non-molecular biologists
LR Watkins, MK Hansen, KT Nguyen, JE Lee, SF Maier |
Life Sciences | 1999 |
Atherosclerosis and inflammation. Patterns of cytokine regulation in patients with peripheral arterial disease
N Fiotti, C Giansante, E Ponte, C Delbello, S Calabrese, T Zacchi, A Dobrina, G Guarnieri |
Atherosclerosis | 1999 |
THE HUMAN INTRACELLULAR INTERLEUKIN 1 RECEPTOR ANTAGONIST PROMOTER APPROPRIATELY REGULATES GENE EXPRESSION IN KERATINOCYTES AND GASTROINTESTINAL EPITHELIAL CELLS IN VIVO
C Gabay, MF Smith, WP Arend |
Cytokine | 1999 |
Acute-Phase Proteins and Other Systemic Responses to Inflammation
FH Epstein, C Gabay, I Kushner |
New England Journal of Medicine | 1999 |
IL-1ra administration does not improve cardiac function in patients with severe sepsis
JL Vincent, G Slotman, PA van Leeuwen, M Shelly, S Nasraway, A Tenaillon, J Bander, G Friedman |
Journal of Critical Care | 1999 |
Circulating Postinjury Neutrophils Are Primed for the Release of Proinflammatory Cytokines:
G Zallen, EE Moore, JL Johnson, DY Tamura, J Aiboshi, WL Biffl, CC Silliman |
The Journal of Trauma: Injury, Infection and Critical Care | 1999 |
Sepsis and Organ Dysfunction
AE Baue, G Berlot, A Gullo, JL Vincent |
1999 | |
Increasing Levels of Interleukin (IL)-1Ra and IL-6 During the First 2 Days of Hospitalization in Unstable Angina Are Associated With Increased Risk of In-Hospital Coronary Events
LM Biasucci, G Liuzzo, G Fantuzzi, G Caligiuri, AG Rebuzzi, F Ginnetti, CA Dinarello, A Maseri |
Circulation | 1999 |
Cytokines, Stress, and Depression
R Dantzer, EE Wollman, R Yirmiya |
1999 | |
Interleukin-4 (IL-4) and IL-13 Enhance the Effect of IL-1β on Production of IL-1 Receptor Antagonist by Human Primary Hepatocytes and Hepatoma HepG2 Cells: Differential Effect on C-Reactive Protein Production
C Gabay, B Porter, D Guenette, B Billir, WP Arend |
Blood | 1999 |
Differential expression of interleukin 1 receptor antagonist isoforms in human intestinal epithelial cells
U Böcker, A Damião, L Holt, DS Han, C Jobin, A Panja, L Mayer, RB Sartor |
Gastroenterology | 1998 |
INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology
WP Arend, M Malyak, CJ Guthridge, C Gabay |
Annual Review of Immunology | 1998 |
HIV infection and malnutrition
A Schwenk |
Current Opinion in Clinical Nutrition and Metabolic Care | 1998 |
Regulation of serum amyloid A protein expression during the acute-phase response
LE Jensen, AS Whitehead |
Biochemical Journal | 1998 |
Relationship between Interleukin-1 and Interleukin-1 Receptor Antagonist during the Development of Fever in the Rata
T Cartmell, S Poole, NJ Rothwell, GN Luheshi |
Annals of the New York Academy of Sciences | 1998 |
Detection of an Interleukin-1 Intracellular Receptor Antagonist mRNA Variant
L Weissbach, K Tran, SA Colquhoun, MF Champliaud, CA Towle |
Biochemical and Biophysical Research Communications | 1998 |
Elevated levels of soluble interleukin-1 receptor type II and interleukin-1 receptor antagonist in patients with chronic arthritis: Correlations with markers of inflammation and joint destruction
P Jouvenne, E Vannier, CA Dinarello, P Miossec |
Arthritis & Rheumatism | 1998 |
Increased circulating cytokine receptors and ex vivo interleukin-1 receptor antagonist and interleukin-1beta production but decreased tumour necrosis factor-alpha production after a 5-km run
Drenth, Krebbers, Bijzet, van der Meer |
European Journal of Clinical Investigation | 1998 |
Prostaglandin-Independent Stimulation of Interleukin-6 Production by Fibrinogen Degradation Product D in Perfused Murine Liver
Csala, Lerant, Banhegyi, Kardon, Puskas, Mucha, Machovich, Falus, Mandl |
Scandinavian Journal of Immunology | 1998 |
Semantics, Inflammation, Cytokines and Common Sense
I Kushner |
Cytokine & Growth Factor Reviews | 1998 |
Kainic acid induced expression of interleukin-1 receptor antagonist mRNA in the rat brain
C Eriksson, B Winblad, M Schultzberg |
Molecular Brain Research | 1998 |
Interleukin (IL)-6 and Its Soluble Receptor Induce TIMP-1 Expression in Synoviocytes and Chondrocytes, and Block IL-1-induced Collagenolytic Activity
P Silacci, JM Dayer, A Desgeorges, R Peter, C Manueddu, PA Guerne |
The Journal of biological chemistry | 1998 |
Secretory Interleukin-1 Receptor Antagonist Gene Expression Requires both a PU.1 and a Novel Composite NF-κB/PU.1/ GA-binding Protein Binding Site
MF Smith, VS Carl, T Lodie, MJ Fenton |
The Journal of biological chemistry | 1998 |
DOES INCREASED URINARY INTERLEUKIN-1 RECEPTOR ANTAGONIST/INTERLEUKIN-1?? RATIO INDICATE GOOD PROGNOSIS IN RENAL TRANSPLANT RECIPIENTS?:
AM Teppo, E Honkanen, J Ahonen, C Gronhagen-Riska |
Transplantation | 1998 |
Treatment of rheumatoid arthritis with IL-1 inhibitors
C Gabay, WP Arend |
Springer Seminars in Immunopathology | 1998 |
Role of pro-inflammatory cytokines in rheumatoid arthritis
FM Brennan, RN Maini, M Feldmann |
Springer Seminars in Immunopathology | 1998 |
Rheumatology
RA Asherson, R Cervera, DP D'Cruz, GR Hughes |
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International Review of Cytology
RA Miller |
International Review of Cytology | 1991 |