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Citations to this article

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.
K S Lown, … , W Guo, P B Watkins
K S Lown, … , W Guo, P B Watkins
Published May 15, 1997
Citation Information: J Clin Invest. 1997;99(10):2545-2553. https://doi.org/10.1172/JCI119439.
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Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.

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Abstract

The increase in oral availability of felodipine and other commonly used medications when taken with grapefruit juice has been assumed to be due to inhibition of CYP3A4, a cytochrome P450 that is present in liver and intestine. To evaluate the effect of repeated grapefruit juice ingestion on CYP3A4 expression, 10 healthy men were given 8 oz of grapefruit juice three times a day for 6 d. Before and after receiving grapefruit juice, small bowel and colon mucosal biopsies were obtained endoscopically, oral felodipine kinetics were determined, and liver CYP3A4 activity was measured with the [14C N-methyl] erythromycin breath test in each subject. Grapefruit juice did not alter liver CYP3A4 activity, colon levels of CYP3A5, or small bowel concentrations of P-glycoprotein, villin, CYP1A1, and CYP2D6. In contrast, the concentration of CYP3A4 in small bowel epithelia (enterocytes) fell 62% (P = 0.0006) with no corresponding change in CYP3A4 mRNA levels. In addition, enterocyte concentrations of CYP3A4 measured before grapefruit juice consumption correlated with the increase in Cmax when felodipine was taken with either the 1st or the 16th glass of grapefruit juice relative to water (r = 0. 67, P = 0.043, and r = 0.71, P = 0.022, respectively). We conclude that a mechanism for the effect of grapefruit juice on oral felodipine kinetics is its selective downregulation of CYP3A4 in the small intestine.

Authors

K S Lown, D G Bailey, R J Fontana, S K Janardan, C H Adair, L A Fortlage, M B Brown, W Guo, P B Watkins

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CS Won, T Lan, KM Vandermolen, PA Dawson, NH Oberlies, WW Widmer, YV Scarlett, MF Paine
Journal of clinical pharmacology 2013
Grapefruit Juice Inhibits the Metabolic Activation of Clopidogrel
MT Holmberg, A Tornio, M Neuvonen, PJ Neuvonen, JT Backman, M Niemi
Clinical Pharmacology & Therapeutics 2013
Combined in Vitro–in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor
EM Matsson, UG Eriksson, JE Palm, P Artursson, M Karlgren, L Lazorova, M Brännström, A Ekdahl, K Dunér, L Knutson, S Johansson, KM Schützer, H Lennernäs
Molecular Pharmaceutics 2013
Grapefruit–medication interactions: Forbidden fruit or avoidable consequences?
DG Bailey, G Dresser, JM Arnold
CMAJ : Canadian Medical Association Journal 2013
Elevated international normalized ratio with the consumption of grapefruit and use of warfarin
AB Bodiford, FO Kessler, JD Fermo, KR Ragucci
SAGE Open Medical Case Reports 2013
Cytochrome P450 Protocols
IR Phillips, EA Shephard, PR de Montellano
2013
Omics for Personalized Medicine
D Barh, D Dhawan, NK Ganguly
2013
Sex and Gender Differences in Pharmacology
V Regitz-Zagrosek
2012
Sex and Gender Differences in Pharmacology
V Regitz-Zagrosek
2012
Sex and Gender Differences in Pharmacology
V Regitz-Zagrosek
2012
Sex and Gender Differences in Pharmacology
V Regitz-Zagrosek
2012
Sex and Gender Differences in Pharmacology
V Regitz-Zagrosek
2012
Sex and Gender Differences in Pharmacology
V Regitz-Zagrosek
2012
Sex and Gender Differences in Pharmacology
V Regitz-Zagrosek
2012
S-ketamine concentrations are greatly increased by grapefruit juice
MA Peltoniemi, TI Saari, NM Hagelberg, K Laine, PJ Neuvonen, KT Olkkola
European Journal of Clinical Pharmacology 2012
Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways
W Jiang, M Hu
RSC Advances 2012
Bioavailability and Bioequivalence
BM Amore
Encyclopedia of Drug Metabolism and Interactions 2012
Oral Absorption: from Physiology to Regulatory
F Berlioz-Seux
Encyclopedia of Drug Metabolism and Interactions 2012
Herb-Drug and Food-Drug Interactions
MS Lennard
Encyclopedia of Drug Metabolism and Interactions 2012
Predicting Human Biotransformation Pathways
S Anderson, D Luffer-Atlas, MP Knadler
Encyclopedia of Drug Metabolism and Interactions 2012
Effect of Grapefruit Juice and Ritonavir on Pharmacokinetics of Lopinavir in Wistar Rats : EFFECT OF GRAPEFRUIT JUICE ON LOPINAVIR PHARMACOKINETICS
PR Ravi, R Vats, R Thakur, S Srivani, N Aditya
Phytotherapy Research 2012
Mechanism-Based Inhibition of Recombinant Human Cytochrome P450 3A4 by Tomato Juice Extract
K Sunaga, K Ohkawa, K Nakamura, A Ohkubo, S Harada, T Tsuda
Biological & Pharmaceutical Bulletin 2012
Safety Evaluation of Fucoidan from Kjellmaniella Crassiforia and Extract from Hypsizigus Marmoreus: Influence on the Activities and Gene Expressions of Rat Hepatic CYPs
H OHNOGI, Y KUDO, S HAYAMI, Y TAKIMOTO, R SUZUKI, N SUZUKI
Japanese Journal of Complementary and Alternative Medicine 2012
Inclusion of human intravenous study data in new drug applications-impact of the japanese guidance
H Imawaka, M Kusama, K Ito, S Ono, Y Sugiyama
Journal of Pharmaceutical Sciences 2012
Immunosuppression
IA MacPhee, T Gelder
Handbook of Renal and Pancreatic Transplantation MacPhee/Handbook of Renal and Pancreatic Transplantation 2012
Phytochemical Modulators of Human Drug Metabolism: Drug Interactions with Fruits, Vegetables, and Botanical Dietary Supplements
B Gurley, KE Fifer, Z Gardner
Encyclopedia of Drug Metabolism and Interactions 2012
Cochrane Database of Systematic Reviews: Protocols
JJ Ho, AS Adnan, Z Darus, NZ Ismail, HV Rostenberghe, JJ Ho
Cochrane Database of Systematic Reviews: Protocols 2012
Encyclopedia of Drug Metabolism and Interactions
M Fielden, C Karbowski
Encyclopedia of Drug Metabolism and Interactions 2012
Metabolism of Drugs and Other Xenobiotics: ANZENBACHER:XENOBIOTICS O-BK
CP Strassburg, S Kalthoff
Metabolism of Drugs and Other Xenobiotics: ANZENBACHER:XENOBIOTICS O-BK 2012
Effects of Grapefruit and Seville Orange Juices on the Pharmacokinetic Properties of Colchicine in Healthy Subjects
S Wason, JL DiGiacinto, MW Davis
Clinical Therapeutics 2012
Fruit Juices as Perpetrators of Drug Interactions: The Role of Organic Anion–Transporting Polypeptides
MJ Dolton, BD Roufogalis, AJ McLachlan
Clinical Pharmacology & Therapeutics 2012
FLAVONOID PHARMACOKINETICS: Methods of Analysis, Preclinical and Clinical Pharmacokinetics, Safety, and Toxicology
JA Yáñez, CM Remsberg, JK Takemoto, KR Vega-Villa, PK Andrews, CL Sayre, SE Martinez, NM Davies
FLAVONOID PHARMACOKINETICS: Methods of Analysis, Preclinical and Clinical Pharmacokinetics, Safety, and Toxicology 2012
Effect of ciprofloxacin and grapefruit juice on oral pharmacokinetics of riluzole in Wistar rats: CYP 1A2 inhibitors and riluzole kinetics
PR Ravi, R Vats, UR Kora
Journal of Pharmacy and Pharmacology 2012
Grapefruit-medication interactions: forbidden fruit or avoidable consequences?
DG Bailey, G Dresser, JM Arnold
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2012
Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport
CS Won, NH Oberlies, MF Paine
Pharmacology & Therapeutics 2012
Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects
MT Holmberg, A Tornio, L Joutsi-Korhonen, M Neuvonen, PJ Neuvonen, R Lassila, M Niemi, JT Backman
British Journal of Clinical Pharmacology 2012
Phase I Studies of Sirolimus Alone or in Combination with Pharmacokinetic Modulators in Advanced Cancer Patients
EE Cohen, K Wu, C Hartford, M Kocherginsky, KN Eaton, Y Zha, A Nallari, ML Maitland, K Fox-Kay, K Moshier, L House, J Ramirez, SD Undevia, GF Fleming, TF Gajewski, MJ Ratain
Clinical cancer research 2012
Effect of cranberry dietary supplements with different brands on human CYP3A4 enzyme
Sompon Wanwimolruk, Supaluk Prachayasittikul, Virapong Prachayasittikul, Bouchra Bernichi
EXCLI J 2012
Ubiquitin-dependent Proteasomal Degradation of Human Liver Cytochrome P450 2E1
YQ Wang, S Guan, P Acharya, DR Koop, Y Liu, M Liao, AL Burlingame, MA Correia
The Journal of biological chemistry 2011
A Critical Analysis of the Interplay between Cytochrome P450 3A and P-Glycoprotein: Recent Insights from Knockout and Transgenic Mice
RA van Waterschoot, AH Schinkel, EE Scott
Pharmacological reviews 2011
Oral Bioavailability
R Singh, M Hu
Oral Bioavailability 2011
Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery
AC Freire, AW Basit, R Choudhary, CW Piong, HA Merchant
International Journal of Pharmaceutics 2011
Individual variability in the disposition of and response to clopidogrel: Pharmacogenomics and beyond
HG Xie, JJ Zou, ZY Hu, JJ Zhang, F Ye, SL Chen
Pharmacology & Therapeutics 2011
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné
Advances in Immunology Volume 110 2011
Different influences on tacrolimus pharmacokinetics by coadministrations of zhi ke and zhi shi in rats
SP Lin, PP Wu, YC Hou, SY Tsai, MJ Wang, SH Fang, PD Chao
Evidence-based complementary and alternative medicine : eCAM 2011
Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren
T Tapaninen, PJ Neuvonen, M Niemi
British Journal of Clinical Pharmacology 2011
Diverse approaches for the enhancement of oral drug bioavailability
P Fasinu, V Pillay, VM Ndesendo, LC du Toit, YE Choonara
Biopharmaceutics & Drug Disposition 2011
Modulation of CYP1A1 activity by a Ginkgo biloba extract in the human intestinal Caco-2 cells
L Ribonnet, A Callebaut, I Nobels, ML Scippo, YJ Schneider, SD Saeger, L Pussemier, Y Larondelle
Toxicology Letters 2011
Potential of anin vitrotoolbox combined with exposure data as a first step for the risk assessment of dietary chemical contaminants
L Ribonnet, E der Heiden, I Nobels, A Chaumont, AS Remacle, SD Saeger, YJ Schneider, ML Scippo, R Blust, L Pussemier, Y Larondelle
Food Additives & Contaminants: Part A 2011
Simulation of Population Variability in Pharmacokinetics
J Yang
Systems Biology in Drug Discovery and Development Young/Systems Bio in Drug Discovery 2011
The effect of grapefruit juice on drug disposition
MJ Hanley, P Cancalon, WW Widmer, DJ Greenblatt
Expert Opinion on Drug Metabolism & Toxicology 2011
Ubiquitin-dependent Proteasomal Degradation of Human Liver Cytochrome P450 2E1: IDENTIFICATION OF SITES TARGETED FOR PHOSPHORYLATION AND UBIQUITINATION
YQ Wang, S Guan, P Acharya, DR Koop, Y Liu, M Liao, AL Burlingame, MA Correia
The Journal of biological chemistry 2011
The basics of pharmacokinetics in prescribing and clinical practice
EU Khan
Nurse Prescribing 2011
薬剤師からみた健康食品・サプリメント
C Ono
Juntendo Medical Journal 2011
Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir
RA van Waterschoot, R Heine, E Wagenaar, CM van der Kruijssen, RW Rooswinkel, AD Huitema, JH Beijnen, AH Schinkel
British Journal of Pharmacology 2010
Differences in the pharmacokinetics of Cyp3a substrates in TSOD and streptozotocin-induced diabetic mice
T Kudo, T Toda, T Ushiki, K Ohi, N Ikarashi, W Ochiai, K Sugiyama
Xenobiotica 2010
Regional Distribution of Cytochrome P450 mRNA Expression in the Liver and Small Intestine of Cynomolgus Monkeys
Y NAKANISHI, A MATSUSHITA, K MATSUNO, K IWASAKI, M UTOH, C NAKAMURA, Y UNO
Drug Metabolism and Pharmacokinetics 2010
The influence of Nifadin®, Niprisan® and Niprd/92/001/1-1 (AM-1) on the pharmacokinetics of metronidazole in rats
MT Bakare-Odunola, KB Mustapha, M Garba, OO Obodozie, IS Enemali
European Journal of Drug Metabolism and Pharmacokinetics 2010
The use of isolated enterocytes to study Phase I intestinal drug metabolism: validation with rat and pig intestine
P Bonnefille, Z Sezgin-Bayindir, H Belkhelfa, C Arellano, P Gandia, J Woodley, G Houin
Fundamental & Clinical Pharmacology 2010
Effects of Ingestion of Grapefruit Juice or Grapefruit on the Hypotensive Effect and Plasma Concentrations of Dihydropyridine Calcium Antagonists (Amlodipine and Nifedipine): A Case Study
K Nakagawa, T Goto
Clinical and Experimental Hypertension 2010
Grapefruit Juice Greatly Reduces the Plasma Concentrations of the OATP2B1 and CYP3A4 Substrate Aliskiren
T Tapaninen, PJ Neuvonen, M Niemi
Clinical Pharmacology & Therapeutics 2010
A rapid ultra-performance liquid chromatography/tandem mass spectrometric methodology for thein vitroanalysis of Pooled and Cocktail cytochrome P450 assays
PG Alden, RS Plumb, MD Jones, PD Rainville, D Shave
Rapid Communications in Mass Spectrometry 2010
Grapefruit Juice Enhances the Exposure to Oral Oxycodone
TH Nieminen, NM Hagelberg, TI Saari, M Neuvonen, PJ Neuvonen, K Laine, KT Olkkola
Basic & Clinical Pharmacology & Toxicology 2010
Influence of Purple Grape Juice in Cyclosporine Bioavailability
VL Oliveira-Freitas, TD Costa, RC Manfro, LB Cruz, G Schwartsmann
Journal of Renal Nutrition 2010
Isolation and Identification of Intestinal CYP3A Inhibitors from Cranberry (Vaccinium macrocarpon) using Human Intestinal Microsomes
E Kim, A Sy-Cordero, TN Graf, SJ Brantley, MF Paine, NH Oberlies
Planta medica 2010
Fruit juice inhibition of uptake transport: a new type of food–drug interaction
DG Bailey
British Journal of Clinical Pharmacology 2010
A dangerous fruit juice
S Agosti, L Casalino, G Bertero, A Barsotti, C Brunelli, S Morelloni
The American Journal of Emergency Medicine 2010
Drug interactions with grapefruit
ZB Z., NB Z., V Bojanic
Medicinski pregled 2010
INFLUENCE OF DIETARY SUBSTANCES ON INTESTINAL DRUG METABOLISM AND TRANSPORT
CS Won, NH Oberlies, MF Paine
Current drug metabolism 2010
Ambient tonicity and intestinal cytochrome CYP3A
AI Chuang, S Ito
Expert Opinion on Drug Metabolism & Toxicology 2010
Effect of Grapefruit Juice on the Pharmacokinetics of Nilotinib in Healthy Participants
OQ Yin, N Gallagher, A Li, W Zhou, R Harrell, H Schran
The Journal of Clinical Pharmacology 2010
xPharm: The Comprehensive Pharmacology Reference
A Vinh
xPharm: The Comprehensive Pharmacology Reference 2010
A Pharmacokinetic Model for Evaluating the Impact of Hepatic and Intestinal First-Pass Loss of Saquinavir in the Rat
R Lledó-García, A Nácher, VG Casabó, M Merino-Sanjuán
Drug Metabolism and Disposition 2010
Grapefruit-Drug Interactions:
K Seden, L Dickinson, S Khoo, D Back
Drugs 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
How important is intestinal cytochrome P450 3A metabolism?
AE van Herwaarden, RA van Waterschoot, AH Schinkel
Trends in Pharmacological Sciences 2009
Cytochrome P450-mediated metabolism in the human gut wall
K Thelen, JB Dressman
Journal of Pharmacy and Pharmacology 2009
Variable Inhibitory Effect of Different Brands of Commercial Herbal Supplements on Human Cytochrome P-450 CYP3A4
S Wanwimolruk, K Wong, P Wanwimolruk
Drug Metabolism and Drug Interactions 2009
Medikamenteninteraktionen in der Geriatrie
A Storka, J Pleiner
Wiener Medizinische Wochenschrift 2009
Effect of phytomedicines, AM-1, niprisan® and nifadin on the pharmacokinetics of chloroquine in rats
KB Mustapha, MT Bakare-Odunola, M Garba, OO Obodozie, IS Enemali, US Inyan
European Journal of Drug Metabolism and Pharmacokinetics 2009
Impact of CYP3A5 and CYP3A4 gene polymorphisms on dose requirement of calcineurin inhibitors, cyclosporine and tacrolimus, in renal allograft recipients of North India
R Singh, A Srivastava, R Kapoor, RK Sharma, RD Mittal
Naunyn-Schmiedeberg's Archives of Pharmacology 2009
CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells
T Sergent, I Dupont, EV der Heiden, ML Scippo, L Pussemier, Y Larondelle, YJ Schneider
Toxicology Letters 2009
Genetic Influences on the Pharmacokinetics of Orally and Intravenously Administered Digoxin as Exhibited by Monozygotic Twins
AL Birkenfeld, J Jordan, U Hofmann, A Busjahn, G Franke, N Krüger, S Igel, T Mürdter, S Drescher, S Shi, S Engeli, M Schwab, M Eichelbaum, FC Luft, MF Fromm
Clinical Pharmacology & Therapeutics 2009
Drug—drug interactions resulting from inhibition of cytochrome P450s
K Yoshinari
Folia Pharmacologica Japonica 2009
Serum cyclosporine level and orange juice in pediatric renal-transplanted patients
H Sorkhi, AA Moghadamnia, F Oaliaee, M PourAmir, AR Firoozjahi, AA Pasha, MR Goodarzi
Pediatric Transplantation 2009
Significantly Altered Systemic Exposure to Atorvastatin Acid Following Gastric Bypass Surgery in Morbidly Obese Patients
IB Skottheim, K Stormark, H Christensen, GS Jakobsen, J Hjelmesæth, T Jenssen, JL Reubsaet, R Sandbu, A Åsberg
Clinical Pharmacology & Therapeutics 2009
Dose–response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles
K Strauch, U Lutz, N Bittner, WK Lutz
Food and Chemical Toxicology 2009
Human clearance prediction: shifting the paradigm
T Lavé, K Chapman, P Goldsmith, M Rowland
Expert Opinion on Drug Metabolism & Toxicology 2009
The grapefruit: an old wine in a new glass? Metabolic and cardiovascular perspectives
PM Owira, JA Ojewole
CARDIOVASC J AFR 2009
Grapefruit juice alters plasma sertraline levels after single ingestion of sertraline in healthy volunteers
N Ueda, R Yoshimura, W Umene-Nakano, A Ikenouchi-Sugita, H Hori, K Hayashi, Y Kodama, J Nakamura
World Journal of Biological Psychiatry 2009
Enzyme- and Transporter-Based Drug-Drug Interactions
KS Pang, AD Rodrigues, RM Peter
2009
Handbook of Drug-Nutrient Interactions
JI Boullata, VT Armenti
2009
RETRACTION: Hepatic CYP3A Suppression by High Concentrations of Proteasomal Inhibitors: A Consequence of Endoplasmic Reticulum (ER) Stress Induction, Activation of RNA-Dependent Protein Kinase-Like ER-Bound Eukaryotic Initiation Factor 2α (eIF2α)-Kinase (PERK) and General Control Nonderepressible-2 eIF2α Kinase (GCN2), and Global Translational Shutoff
P Acharya, JC Engel, MA Correia
Molecular pharmacology 2009
Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver
RA van Waterschoot, RW Rooswinkel, E Wagenaar, CM van der Kruijssen, AE van Herwaarden, AH Schinkel
The FASEB Journal 2008
Reply
J Bommer, T Heinrich, H Heidt, V Hafner, E Jenetzky, I Walter-Sack, G Mikus
Nephrology Dialysis Transplantation 2008
Relationship between Lipophilicities of 1,4-Dihydropyridine Derivatives and Pharmacokinetic Interaction Strengths with Grapefruit Juice
Y UESAWA, K MOHRI
YAKUGAKU ZASSHI 2008
Examining sex-related differences in enteric itraconazole metabolism in healthy adults using grapefruit juice
PO Gubbins, BJ Gurley, DK Williams, SR Penzak, SA McConnell, AM Franks, M Saccente
European Journal of Clinical Pharmacology 2008
Species differences inin vitro andin vivo small intestinal metabolism of CYP3A substrates
H Komura, M Iwaki
Journal of Pharmaceutical Sciences 2008
Review Article: Cytochrome P450 enzyme, and transport protein mediated herb–drug interactions in renal transplant patients: Grapefruit juice, St John's Wort – and beyond! (Review Article)
R Nowack
Nephrology 2008
Comparative Evaluation of 12 Immature Citrus Fruit Extracts for the Inhibition of Cytochrome P450 Isoform Activities
T Fujita, A Kawase, T Niwa, N Tomohiro, M Masuda, H Matsuda, M Iwaki
Biological & Pharmaceutical Bulletin 2008
In vivoassessment of herb–drug interactions: Possible utility of a pharmacogenetic approach?
B Tomlinson, M Hu, VW Lee
Molecular Nutrition & Food Research 2008
Influence of fruit juices on drug disposition: discrepancies betweenin vitroand clinical studies
D Farkas, DJ Greenblatt
Expert Opinion on Drug Metabolism & Toxicology 2008
Potential role of intestinal first-pass metabolism in the prediction of drug–drug interactions
A Galetin, M Gertz, JB Houston
Expert Opinion on Drug Metabolism & Toxicology 2008
Clinically Significant Grapefruit Juice-Drug Interactions
WW McCloskey, K Zaiken, RR Couris
Nutrition Today 2008
Laboratory diet profoundly alters gene expression and confounds genomic analysis in mouse liver and lung
CD Kozul, AP Nomikos, TH Hampton, LA Warnke, JA Gosse, JC Davey, JE Thorpe, BP Jackson, MA Ihnat, JW Hamilton
Chemico-Biological Interactions 2008
Molecular and cellular effects of food contaminants and secondary plant components and their plausible interactions at the intestinal level
T Sergent
Food and Chemical Toxicology 2008
Effects of dietary salt on the expression of drug transporters, cytochrome P4503a, and nuclear receptors in rats
HJ Kang, IS Song, SS Lee, MA Yoo, JG Shin
Xenobiotica 2008
Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability
H de Waterbeemd, B Testa
Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability 2008
Further characterization of a furanocoumarin-free grapefruit juice on drug disposition: studies with cyclosporine
MF Paine, WW Widmer, SN Pusek, KL Beavers, AB Criss, J Snyder, PB Watkins
The American journal of clinical nutrition 2008
Advances in Bioactivation Research
A Elfarra
2008
Effect of Grapefruit Juice, Naringin, Naringenin, and Bergamottin on the Intestinal Carrier-Mediated Transport of Talinolol in Rats
WV de Castro, S Mertens-Talcott, H Derendorf, V Butterweck
Journal of Agricultural and Food Chemistry 2008
Intestinal Drug Transporter Expression and the Impact of Grapefruit Juice in Humans
H Glaeser, DG Bailey, GK Dresser, JC Gregor, UI Schwarz, JS McGrath, E Jolicoeur, W Lee, BF Leake, RG Tirona, RB Kim
Clinical Pharmacology & Therapeutics 2007
Medicinal importance of grapefruit juice and its interaction with various drugs
J Kiani, SZ Imam
Nutrition Journal 2007
Prospective study of grapefruit intake and risk of breast cancer in postmenopausal women: the Multiethnic Cohort Study
KR Monroe, SP Murphy, LN Kolonel, MC Pike
British Journal of Cancer 2007
Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97?
S Faouzi, KF Medzihradszky, C Hefner, JJ Maher, MA Correia
Biochemistry 2007
Effects of clarithromycin and grapefruit juice on the pharmacokinetics of glibenclamide
JJ Lilja, M Niemi, H Fredrikson, PJ Neuvonen
British Journal of Clinical Pharmacology 2007
Clinical relevance of the small intestine as an organ of drug elimination: drug–fruit juice interactions
MF Paine, NH Oberlies
Expert Opinion on Drug Metabolism & Toxicology 2007
Naringin is a Major and Selective Clinical Inhibitor of Organic Anion-Transporting Polypeptide 1A2 (OATP1A2) in Grapefruit Juice
DG Bailey, GK Dresser, BF Leake, RB Kim
Clinical Pharmacology & Therapeutics 2007
Effect of tangerine juice on cyclosporine levels in renal transplant children
H Sorkhi, AA Moghadamnia, F Oaliaee, M PourAmir, AR Firoozjahi, AA Pasha, MR Goodarzi
Pediatric Nephrology 2007
Effects of Daily Ingestion of Cranberry Juice on the Pharmacokinetics of Warfarin, Tizanidine, and Midazolam—Probes of CYP2C9, CYP1A2, and CYP3A4
JJ Lilja, JT Backman, PJ Neuvonen
Clinical Pharmacology & Therapeutics 2007
Interaction of Herbal Constituents with Cytochrome P450 Enzymes
E Yarnell, K Abascal
Alternative and Complementary Therapies 2007
Cellular proteolytic systems in P450 degradation: evolutionary conservation fromSaccharomycescerevisiaeto mammalian liver
MA Correia, M Liao
Expert Opinion on Drug Metabolism & Toxicology 2007
Side Effects of Drugs Annual
T Vial, J Descotes, F Braun, M Behrend
Side Effects of Drugs Annual 2007
Principles of Clinical Pharmacology
CS Stika, MC Frederiksen
Principles of Clinical Pharmacology 2007
Drug-Induced Liver Disease, Second Edition
M Pirmohamed, S Leeder
Drug-Induced Liver Disease, Second Edition 2007
The Additive Effects of the Active Component of Grapefruit Juice (Naringenin) and Antiarrhythmic Drugs on HERG Inhibition
C Lin, X Ke, V Ranade, J Somberg
Cardiology 2007
Decreased Expression of Breast Cancer Resistance Protein in the Duodenum in Patients with Obstructive Cholestasis
C Zimmermann, P Hruz, H Gutmann, L Terracciano, U Beuers, F Lehmann, C Beglinger, J Drewe
Digestion 2006
Stereoselective interaction of manidipine and grapefruit juice: a new twist on an old tale
B Tomlinson, MS Chow
British Journal of Clinical Pharmacology 2006
Effects of cranberry juice on nifedipine pharmacokinetics in rats
Y Uesawa, K Mohri
Journal of Pharmacy and Pharmacology 2006
Major determinant factors of the extent of interaction between grapefruit juice and calcium channel antagonists
A Ohnishi, H Ohtani, Y Sawada
British Journal of Clinical Pharmacology 2006
Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects
T Uno, T Ohkubo, S Motomura, K Sugawara
British Journal of Clinical Pharmacology 2006
Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics
SW Grimm, NM Richtand, HR Winter, KR Stams, SB Reele
British Journal of Clinical Pharmacology 2006
Interaction between grapefruit juice and hypnotic drugs: comparison of triazolam and quazepam
K Sugimoto, N Araki, M Ohmori, K Harada, Y Cui, S Tsuruoka, A Kawaguchi, A Fujimura
European Journal of Clinical Pharmacology 2006
UV-Irradiated Grapefruit Juice Loses Pharmacokinetic Interaction with Nifedipine in Rats
Y Uesawa, K Mohri
Biological & Pharmaceutical Bulletin 2006
Delayed Effect of Grapefruit Juice on Pharmacokinetics and Pharmacodynamics of Tacrolimus in a Living-Donor Liver Transplant Recipient
S FUKATSU, M FUKUDO, S MASUDA, I YANO, T KATSURA, Y OGURA, F OIKE, Y TAKADA, K INUI
Drug Metabolism and Pharmacokinetics 2006
NARINGIN DOES NOT ALTER CAFFEINE PHARMACOKINETICS, ENERGY EXPENDITURE, OR CARDIOVASCULAR HAEMODYNAMICS IN HUMANS FOLLOWING CAFFEINE CONSUMPTION
TL Ballard, FT Halaweish, CL Stevermer, P Agrawal, MD Vukovich
Clinical and Experimental Pharmacology and Physiology 2006
Active Drug Transport of Immunosuppressants
U Christians, T Strom, YL Zhang, W Steudel, V Schmitz, S Trump, M Haschke
Therapeutic Drug Monitoring 2006
Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors
H Blume, F Donath, A Warnke, BS Schug
Drug Safety 2006
Docosahexaenoic acid (DHA) inhibits saquinavir metabolism in-vitro and enhances its bioavailability in rats
V Hirunpanich, H Sato
Journal of Pharmacy and Pharmacology 2006
The Use of Heat Treatment to Eliminate Drug Interactions Due to Grapefruit Juice
Y Uesawa, K Mohri
Biological & Pharmaceutical Bulletin 2006
VARIATIONS IN CONTENT OF ACTIVE INGREDIENTS CAUSING DRUG INTERACTIONS IN GRAPEFRUIT JUICE PRODUCTS SOLD IN CALIFORNIA
S Wanwimolruk, PV Marquez
Drug Metabolism and Drug Interactions 2006
Active Drug Transport of Immunosuppressants: New Insights for Pharmacokinetics and Pharmacodynamics
U Christians, T Strom, YL Zhang, W Steudel, V Schmitz, S Trump, M Haschke
Therapeutic Drug Monitoring 2006
Drugs and the Pharmaceutical Sciences: Scientific and Regulatory Perspectives
I Zadezensky, H Derendorf, V Butterweck, S Mertens-Talcott, WD Castro
Drugs and the Pharmaceutical Sciences 2006
Drug-Drug Interaction After Single Oral Doses of the Furanocoumarin Methoxsalen and Cyclosporine
M Rheeders, M Bouwer, TC Goosen
The Journal of Clinical Pharmacology 2006
Grapefruit-Drug Interactions: Can Interactions With Drugs Be Avoided?
SU Mertens-Talcott, I Zadezensky, WV de Castro, H Derendorf, V Butterweck
The Journal of Clinical Pharmacology 2006
A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice–felodipine interaction
MF Paine, WW Widmer, HL Hart, SN Pusek, KL Beavers, AB Criss, SS Brown, BF Thomas, PB Watkins
The American journal of clinical nutrition 2006
The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 C3435T polymorphisms and gender on the urinary excretion of the metabolites of the H1-receptor antihistamine ebastine: a pilot study
G Gervasini, S Vizcaino, JA Carrillo, MJ Caballero, J Benitez
British Journal of Clinical Pharmacology 2006
Lopinavir/Ritonavir Induces the Hepatic Activity of Cytochrome P450 Enzymes CYP2C9, CYP2C19, and CYP1A2 But Inhibits the Hepatic and Intestinal Activity of CYP3A as Measured by a Phenotyping Drug Cocktail in Healthy Volunteers
RF Yeh, VE Gaver, KB Patterson, NL Rezk, F Baxter-Meheux, MJ Blake, JJ Eron, CE Klein, JC Rublein, AD Kashuba
Journal of acquired immune deficiency syndromes (1999) 2006
Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors:
H Blume, F Donath, A Warnke, BS Schug
Drug Safety 2006
Oral tolerance
AM Faria, HL Weiner
Immunological Reviews 2005
Nutrition and Disease Prevention
K Imaizumi
Soy in Health and Disease Prevention 2005
Food-Drug Synergy and Safety
A Bree, P Galan, L Mennen
Food-Drug Synergy and Safety 2005
Cytochromes P450 and MDR1 mRNA expression along the human gastrointestinal tract
M Thörn, N Finnström, S Lundgren, A Rane, L Lööf
British Journal of Clinical Pharmacology 2005
Impact of citrus soft drinks relative to grapefruit juice on ciclosporin disposition
UI Schwarz, PE Johnston, DG Bailey, RB Kim, G Mayo, A Milstone
British Journal of Clinical Pharmacology 2005
Effects of grapefruit juice on the pharmacokinetics of acebutolol
JJ Lilja, K Raaska, PJ Neuvonen
British Journal of Clinical Pharmacology 2005
Effects of grapefruit juice on the absorption of levothyroxine
JJ Lilja, K Laitinen, PJ Neuvonen
British Journal of Clinical Pharmacology 2005
A Higher Dose Requirement of Tacrolimus in Active Crohn's Disease May Be Related to a High Intestinal P-Glycoprotein Content
AL Buchman, MF Paine, A Wallin, SS Ludington
Digestive Diseases and Sciences 2005
Effects of orange juice on the pharmacokinetics of atenolol
JJ Lilja, K Raaska, PJ Neuvonen
European Journal of Clinical Pharmacology 2005
Effect of Grapefruit Juice Volume on the Reduction of Fexofenadine Bioavailability: Possible Role of Organic Anion Transporting Polypeptides*
GK Dresser, RB Kim, DG Bailey
Clinical Pharmacology & Therapeutics 2005
Intestinal Expression and Metabolic Activity of the CYP3A Subfamily in Female Rats
T Aiba, M Yoshinaga, K Ishida, Y Takehara, Y Hashimoto
Biological & Pharmaceutical Bulletin 2005
Effects of Sweetie Juice on Nifedipine Pharmacokinetics in Rats
Y UESAWA, K MOHRI
YAKUGAKU ZASSHI 2005
Inhibition of Human Intestinal Wall Metabolism by Macrolide Antibiotics: Effect of Clarithromycin on Cytochrome P450 3A4/5 Activity and Expression*
AG Pinto, YH Wang, N Chalasani, T Skaar, D Kolwankar, JC Gorski, S Liangpunsakul, MA Hamman, M Arefayene, SD Hall
Clinical Pharmacology & Therapeutics 2005
Health-related Interactions of Phytochemicals
MA Lila, I Raskin
Journal of Food Science 2005
Functional interactions between P-glycoprotein and CYP3A in drug metabolism
U Christians, V Schmitz, M Haschke
Expert Opinion on Drug Metabolism & Toxicology 2005
Diltiazem inhibits human intestinal cytochrome P450 3A (CYP3A) activity in vivo without altering the expression of intestinal mRNA or protein
AG Pinto, J Horlander, N Chalasani, M Hamman, A Asghar, D Kolwankar, SD Hall
British Journal of Clinical Pharmacology 2005
Progress in Pharmaceutical and Biomedical Analysis
A Ghosal, R Ramanathan, NS Kishnani, SK Chowdhury, KB Alton
Progress in Pharmaceutical and Biomedical Analysis 2005
The Influence of Age and Sex on the Clearance of Cytochrome P450 3A Substrates:
MM Cotreau, LL von Moltke, DJ Greenblatt
Clinical Pharmacokinetics 2005
Undesirable Effects of Citrus Juice on the Pharmacokinetics of Drugs: Focus on Recent Studies
M Saito, M Hirata-Koizumi, M Matsumoto, T Urano, R Hasegawa
Drug Safety 2005
Cytochrome P450
PR de Montellano
Cytochrome P450 2005
What's the Scoop with Grapefruit?
ES Sterling, KM Smith
Orthopedics 2005
CITRUS JUICES INHIBIT THE FUNCTION OF HUMAN ORGANIC ANION-TRANSPORTING POLYPEPTIDE OATP-B
H Satoh, F Yamashita, M Tsujimoto, H Murakami, N Koyabu, H Ohtani, Y Sawada
Drug Metabolism and Disposition 2005
Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin
JJ Lilja, M Neuvonen, PJ Neuvonen
British Journal of Clinical Pharmacology 2004
CYP3A in horse intestines
E Tydén, L Olsén, J Tallkvist, P Larsson, H Tjälve
Toxicology and Applied Pharmacology 2004
Effects of grapefruit juice on pharmacokinetics of atorvastatin and pravastatin in Japanese
I Fukazawa, N Uchida, E Uchida, H Yasuhara
British Journal of Clinical Pharmacology 2004
Screening of Furanocoumarin Derivatives in Citrus Fruits by Enzyme-Linked Immunosorbent Assay
T Saita, H Fujito, M Mori
Biological & Pharmaceutical Bulletin 2004
Impact of inter-individual differences in drug metabolism and pharmacokinetics on safety evaluation
JL Dorne
Fundamental and Clinical Pharmacology 2004
Effect of fruit juices on the oral bioavailability of fexofenadine in rats
AV Kamath, M Yao, Y Zhang, S Chong
Journal of Pharmaceutical Sciences 2004
Effects of Continuous Ingestion of Green Tea or Grape Seed Extracts on the Pharmacokinetics of Midazolam
M NISHIKAWA, N ARIYOSHI, A KOTANI, I ISHII, H NAKAMURA, H NAKASA, M IDA, H NAKAMURA, N KIMURA, M KIMURA, A HASEGAWA, F KUSU, S OHMORI, K NAKAZAWA, M KITADA
Drug Metabolism and Pharmacokinetics 2004
Influence of Hepatic and Intestinal Cytochrome P4503A Activity on the Acute Disposition and Effects of Oral Transmucosal Fentanyl Citrate
ED Kharasch, D Whittington, C Hoffer
Anesthesiology 2004
FOOD-DRUG INTERACTIONS VIA HUMAN CYTOCHROME P450 3A (CYP3A)
K Fujita
Drug Metabolism and Drug Interactions 2004
Influence of Grapefruit Juice on the Systemic Availability of Itraconazole Oral Solution in Healthy Adult Volunteers
PO Gubbins, SA McConnell, BJ Gurley, TK Fincher, AM Franks, DK Williams, SR Penzak, M Saccente
Pharmacotherapy 2004
Differences in Drug Pharmacokinetics Between East Asians and Caucasians and the Role of Genetic Polymorphisms
K Kim, JA Johnson, H Derendorf
The Journal of Clinical Pharmacology 2004
Pharmacokinetics in older persons
BJ Cusack
The American journal of geriatric pharmacotherapy 2004
Drug interactions in dentistry
EV Hersh, PA Moore
The Journal of the American Dental Association 2004
Complementary and Alternative Cardiovascular Medicine
RA Stein, MC Oz
2004
Handbook of Drug Interactions
A Mozayani, LP Raymon
2004
Interactions Between Grapefruit Juice and Cardiovascular Drugs:
DG Bailey, GK Dresser
American Journal Cardiovascular Drugs 2004
Clinical Pharmacokinetics of Thalidomide:
SK Teo, WA Colburn, WG Tracewell, KA Kook, DI Stirling, MS Jaworsky, MA Scheffler, SD Thomas, OL Laskin
Clinical Pharmacokinetics 2004
Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis Volume 3
DZ DArgenio
2004
Beverages in Nutrition and Health
T Wilson, NJ Temple
2004
Applications of Pharmacokinetic Principles in Drug Development
R Krishna
2004
Contributions of CYP3A4, P-glycoprotein, and Serum Protein Binding to the Intestinal First-Pass Extraction of Saquinavir
SJ Mouly, MF Paine, PB Watkins
The Journal of pharmacology and experimental therapeutics 2004
DO MEN AND WOMEN DIFFER IN PROXIMAL SMALL INTESTINAL CYP3A OR P-GLYCOPROTEIN EXPRESSION?
MF Paine, SS Ludington, ML Chen, PW Stewart, SM Huang, PB Watkins
Drug Metabolism and Disposition 2004
TWO MAJOR GRAPEFRUIT JUICE COMPONENTS DIFFER IN INTESTINAL CYP3A4 INHIBITION KINETIC AND BINDING PROPERTIES
MF Paine, AB Criss, PB Watkins
Drug Metabolism and Disposition 2004
Two Major Grapefruit Juice Components Differ in Time to Onset of Intestinal CYP3A4 Inhibition
MF Paine, AB Criss, PB Watkins
The Journal of pharmacology and experimental therapeutics 2004
The Grapefruit Juice Effect Is Not Limited to Cytochrome P450 (P450) 3A4: Evidence for Bergamottin-Dependent Inactivation, Heme Destruction, and Covalent Binding to Protein in P450s 2B6 and 3A5
H Lin, UM Kent, PF Hollenberg
The Journal of pharmacology and experimental therapeutics 2004
Factors Responsible for the Variability of Saquinavir Absorption: Studies Using an Instrumented Dog Model
N Tam-Zaman, YK Tam, S Tawfik, H Wiltshire
Pharmaceutical Research 2004
INDUCTION OFDRUG-METABOLIZINGENZYMES: A Path to the Discovery of Multiple Cytochromes P450*
AH Conney
Annual Review of Pharmacology and Toxicology 2003
Phytochemical functional foods
F Virgili, C Scaccini, L Packer, G Rimbach
Phytochemical functional foods 2003
The effects of fruit juices on drug disposition: a new model for drug interactions
GK Dresser, DG Bailey
European Journal of Clinical Investigation 2003
Variable expression of CYP and Pgp genes in the human small intestine
M Lindell, MO Karlsson, H Lennernas, L Pahlman, MA Lang
European Journal of Clinical Investigation 2003
Interactions of grapefruit juice and cardiovascular medications: A potential risk of toxicity
GE Lim, T Li, HS Buttar
Experimental and clinical cardiology 2003
HUMANEXTRAHEPATICCYTOCHROMESP450: Function in Xenobiotic Metabolism and Tissue-Selective Chemical Toxicity in the Respiratory and Gastrointestinal Tracts*
X Ding, LS Kaminsky
Annual Review of Pharmacology and Toxicology 2003
Gender-Specific Implications for Cardiovascular Medication Use in the Elderly
JB Schwartz
Cardiology in Review 2003
Dietary Supplements of Plant Origin
J Cott
Dietary Supplements of Plant Origin 2003
Antihypertensive therapy: special focus on drug interactions
R Maas, RH Böger
Expert Opinion on Drug Safety 2003
Inhibitory Effects of Citrus Fruits on Cytochrome P450 3A (CYP3A) Activity in Humans
K Fujita, M Hidaka, N Takamura, K Yamasaki, T Iwakiri, M Okumura, H Kodama, M Yamaguchi, T Ikenoue, K Arimori
Biological & Pharmaceutical Bulletin 2003
Simple and sensitive high-performance liquid chromatography method for simultaneous determination of urinary free cortisol and 6β-hydroxycortisol in routine practice
E Rouits, M Boisdron-Celle, A Morel, E Gamelin
Journal of Chromatography B 2003
Grapefruit Juice-fluvoxamine Interaction
H Hori, R Yoshimura, N Ueda, S Eto, K Shinkai, S Sakata, O Ohmori, T Terao, J Nakamura
Journal of Clinical Psychopharmacology 2003
Nature, nurture and human disease
A Chakravarti, P Little
Nature 2003
Drug interactions: a review and update
BE Byrne
Endodontic Topics 2003
Effects of Grapefruit Juice on Intestinal P-glycoprotein: Evaluation Using Digoxin in Humans
RB Parker, CR Yates, JE Soberman, SC Laizure
Pharmacotherapy 2003
In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products
BC Foster, S Vandenhoek, J Hana, A Krantis, MH Akhtar, M Bryan, JW Budzinski, A Ramputh, JT Arnason
Phytomedicine 2003
Drugs and the Pharmaceutical Sciences
D Thompson
Drugs and the Pharmaceutical Sciences 2003
Exposure-Dependent Inhibition of Intestinal and Hepatic CYP3A4 In Vivo by Grapefruit Juice
ML Veronese, LP Gillen, JP Burke, EP Dorval, WW Hauck, E Pequignot, SA Waldman, HE Greenberg
The Journal of Clinical Pharmacology 2003
Sho-saiko-to and Saiko-keisi-to, the traditional Chinese and Japanese herbal medicines, altered hepatic drug-metabolizing enzymes in mice and rats when administered orally for a long time
M Nose, M Tamura, N Ryu, H Mizukami, Y Ogihara
Journal of Pharmacy and Pharmacology 2003
Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery and Development
K Bachmann, S Wrighton, B Ring
Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery and Development 2003
Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man
RA Mirghani, Ö Ericsson, G Tybring, LL Gustafsson, L Bertilsson
European Journal of Clinical Pharmacology 2003
Measurement of hepatic and intestinal CYP3A4 and PGP activity by combined po + iv [ 14 C]erythromycin breath and urine test
WP Lemahieu, BD Maes, Y Ghoos, P Rutgeerts, K Verbeke, Y Vanrenterghem
AJP Gastrointestinal and Liver Physiology 2003
Food–drug interaction: grapefruit juice augments drug bioavailability—mechanism, extent and relevance
A Dahan, H Altman
European Journal of Clinical Nutrition 2003
Effects of liquid and freeze-dried grapefruit juice on the pharmacokinetics of praziquantel and its metabolite 4′-hydroxy praziquantel in beagle dogs
M Giorgi, V Meucci, E Vaccaro, G Mengozzi, M Giusiani, G Soldani
Pharmacological research : the official journal of the Italian Pharmacological Society 2003
Management of Calcium Channel Antagonist Overdose:
SD Salhanick, MW Shannon
Drug Safety 2003
Dietary Effects on Drug Metabolism and Transport:
RZ Harris, GR Jang, S Tsunoda
Clinical Pharmacokinetics 2003
Factors Affecting the Clinical Development of Cytochrome P450 3A Substrates:
MA Gibbs, NA Hosea
Clinical Pharmacokinetics 2003
MODELING OF INTESTINAL DRUG ABSORPTION: ROLES OF TRANSPORTERS AND METABOLIC ENZYMES (FOR THE GILLETTE REVIEW SERIES)
KS Pang
Drug Metabolism and Disposition 2003
THE SMALL INTESTINE AS A XENOBIOTIC-METABOLIZING ORGAN
LS Kaminsky, QY Zhang
Drug Metabolism and Disposition 2003
50 Years of DNA
J Clayton, C Dennis
2003
Modulation of digoxin transport across Caco-2 cell monolayers by citrus fruit juices: lime, lemon, grapefruit, and pummelo
Jianguo Xu, Mei Lin Go, Lee-Yong Lim
Pharmaceutical Research 2003
Drug–phytochemical interactions
C Ioannides
Inflammopharmacology 2003
P-glycoprotein increases from proximal to distal regions of human small intestine
Stéphane Mouly, Mary F Paine
Pharmaceutical Research 2003
Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?
S Wanwimolruk, MF Paine, SN Pusek, PB Watkins
British Journal of Clinical Pharmacology 2002
An in vitro examination of the impact of polyethylene glycol 400, Pluronic P85, and vitamin E d-alpha-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine
BM Johnson, WN Charman, CJ Porter
AAPS PharmSci 2002
Intestinal first pass metabolism of midazolam in liver cirrhosis --effect of grapefruit juice
V Andersen, N Pedersen, NE Larsen, J Sonne, S Larsen
British Journal of Clinical Pharmacology 2002
Interaction between grapefruit juice and praziquantel in humans
N Castro, H Jung, R Medina, D González-Esquivel, M Lopez, J Sotelo
Antimicrobial agents and chemotherapy 2002
Grapefruit juice: potential drug interactions
J Maskalyk
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2002
Drug-nutrient interaction in clinical nutrition
LN Chan
Current Opinion in Clinical Nutrition and Metabolic Care 2002
Amino acids in SRS1 and SRS6 are critical for furanocoumarin metabolism by CYP6B1v1, a cytochrome P450 monooxygenase
JS Chen, MR Berenbaum, MA Schuler
Insect Molecular Biology 2002
On the assessment of effects of food on the pharmacokinetics of drugs in early development
Z Li, NN Vachharajani, R Krishna
Biopharmaceutics & Drug Disposition 2002
Effects of Single and Repeated Treatment with Itraconazole on the Pharmacokinetics of Midazolam in Rats
Y SAWADA, S TAKEDOMI, H MATSUO, K YAMANO, T IGA, H OHTANI
Drug Metabolism and Pharmacokinetics 2002
Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity
L Zou, MR Harkey, GL Henderson
Life Sciences 2002
Mechanisms of Clinically Relevant Drug Interactions Associated with Tacrolimus
U Christians, W Jacobsen, LZ Benet, A Lampen
Clinical Pharmacokinetics 2002
A Mechanistic Approach to Understanding the Factors Affecting Drug Absorption: A Review of Fundamentals
MN Martinez, GL Amidon
The Journal of Clinical Pharmacology 2002
Grapefruit juice potentiates the anti-inflammatory effects of diclofenac on the carrageenan-induced rat’s paw oedema
AA Mahgoub
Pharmacological Research 2002
Pharmacokinetic interactions between herbal remedies and medicinal drugs
C Ioannides
Xenobiotica 2002
Investigation of the Coordinated Functional Activities of Cytochrome P450 3A4 and P‐Glycoprotein in Limiting the Absorption of Xenobiotics in Caco‐2 Cells
CD Tran, P Timmins, BR Conway, WJ Irwin
Journal of Pharmaceutical Sciences 2002
Effect of Oral Ketoconazole on First‐pass Effect of Nifedipine After Oral Administration in Dogs
M Kuroha, H Kayaba, S Kishimoto, WF Khalil, M Shimoda, E Kokue
Journal of Pharmaceutical Sciences 2002
Tropical Review: Zonisamide in Pediatric Epilepsy: Review of the Japanese Experience
TA Glauser, JM Pellock
Journal of child neurology 2002
Understanding drug interactions
B Maher, M Pirmohamed
Nursing and Residential Care 2002
Unmasking the Dynamic Interplay between Intestinal P-Glycoprotein and CYP3A4
CL Cummins, W Jacobsen, LZ Benet
The Journal of pharmacology and experimental therapeutics 2002
Effects of Bergamottin on Human and Monkey Drug-Metabolizing Enzymes in Primary Cultured Hepatocytes
YH Wen, J Sahi, E Urda, S Kulkarni, K Rose, X Zheng, JF Sinclair, H Cai, SC Strom, VE Kostrubsky
Drug Metabolism and Disposition 2002
The Effect of Bergamottin on Diazepam Plasma Levels and P450 Enzymes in Beagle Dogs
J Sahi, EL Reyner, JN Bauman, K Gueneva-Boucheva, JE Burleigh, VH Thomas
Drug Metabolism and Disposition 2002
Intestinal Metabolism Promotes Regional Differences in Apical Uptake of Indinavir: Coupled Effect of P-Glycoprotein and Cytochrome P450 3A on Indinavir Membrane Permeability in Rat
LY Li, GL Amidon, JS Kim, T Heimbach, F Kesisoglou, JT Topliss, D Fleisher
The Journal of pharmacology and experimental therapeutics 2002
Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates
Run Tian, Noriko Koyabu, Hitomi Takanaga, Hirotami Matsuo, Hisakazu Ohtani, Yasufumi Sawada
Pharmaceutical Research 2002
Mechanisms of Clinically Relevant Drug Interactions Associated with Tacrolimus:
U Christians, W Jacobsen, LZ Benet, A Lampen
Clinical Pharmacokinetics 2002
INTERINDIVIDUALVARIABILITY ININHIBITION ANDINDUCTION OFCYTOCHROMEP450 ENZYMES
JH Lin, AY Lu
Annual Review of Pharmacology and Toxicology 2001
Strategies to overcome simultaneous P-glycoprotein mediated efflux and CYP3A4 mediated metabolism of drugs
J Patel, AK Mitra
Pharmacogenomics 2001
Therapeutic potential of dietary phase 2 enzyme inducers in ameliorating diseases that have an underlying inflammatory component
BH Juurlink
Canadian Journal of Physiology and Pharmacology 2001
Drug Interactions With Grapefruit Juice: An Update
DJ Greenblatt, KC Patki, LL von Moltke, RI Shader
Journal of Clinical Psychopharmacology 2001
Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice
Z Desta, KT Kivistö, JJ Lilja, JT Backman, N Soukhova, PJ Neuvonen, DA Flockhart
British Journal of Clinical Pharmacology 2001
EFFECT OF GRAPEFRUIT JUICE ON URINARY LITHOGENICITY
DS Goldfarb, JR Asplin
The Journal of Urology 2001
Predicting the impact of physiological and biochemical processes on oral drug bioavailability
B Agoram, WS Woltosz, MB Bolger
Advanced Drug Delivery Reviews 2001
Race but Not Age Affects Erythromycin Breath Test Results in Older Hypertensive Men
JB Schwartz
The Journal of Clinical Pharmacology 2001
Effect of Grapefruit Juice on Pharmacokinetics of Microemulsion Cyclosporine in African American Subjects Compared with Caucasian Subjects: Does Ethnic Difference Matter?
M Lee, DI Min, YM Ku, M Flanigan
The Journal of Clinical Pharmacology 2001
Nutrition et médicaments: mise au point sur les aspects pharmacocinétiques
S Saivin, G Houin
Revue Française des Laboratoires 2001
Drug-Nutrient Interactions in Transplant Recipients
LN Chan
JPEN. Journal of parenteral and enteral nutrition 2001
Effect of grapefruit juice on Sandimmun Neoral® absorption among stable renal allograft recipients
C Bistrup, FT Nielsen, UE Jeppesen, H Dieperink
Nephrology Dialysis Transplantation 2001
The Gut as a Barrier to Drug Absorption: Combined Role of Cytochrome P450 3A and P-Glycoprotein
Y Zhang, LZ Benet
Clinical Pharmacokinetics 2001
Pharmacokinetic Aspects of Treating Infections in the Intensive Care Unit: Focus on Drug Interactions
F Pea, M Furlanut
Clinical Pharmacokinetics 2001
Drug Interactions in Infectious Diseases
SC Piscitelli, KA Rodvold
2001
Medical Challenges for the New Millennium
SN Willich, S Elm
2001
Herb-Drug Interactions: Focus on Pharmacokinetics
JM Cott
CNS Spectrums 2001
Lipids, lipophilic drugs, and oral drug delivery?Some emerging concepts
WN Charman
Journal of Pharmaceutical Sciences 2000
The Effect of Rifampin Treatment on Intestinal Expression of Human MRP Transporters
MF Fromm, HM Kauffmann, P Fritz, O Burk, HK Kroemer, RW Warzok, M Eichelbaum, W Siegmund, D Schrenk
The American Journal of Pathology 2000
Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4
A Ohnishi, H Matsuo, S Yamada, H Takanaga, S Morimoto, Y Shoyama, H Ohtani, Y Sawada
British Journal of Pharmacology 2000
Formation of omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by grapefruit juice
W Tassaneeyakul, S Vannaprasaht, Y Yamazoe
British Journal of Clinical Pharmacology 2000
Pharmacokinetic analysis of felodipine-grapefruit juice interaction based on an irreversible enzyme inhibition model
H Takanaga, A Ohnishi, H Matsuo, H Murakami, H Sata, K Kuroda, A Urae, S Higuchi, Y Sawada
British Journal of Clinical Pharmacology 2000
Modulation of oral bioavailability of anticancer drugs: from mouse to man
JH Schellens, MM Malingré, CM Kruijtzer, HA Bardelmeijer, O Tellingen, AH Schinkel, JH Beijnen
European Journal of Pharmaceutical Sciences 2000
Immunochemical Identification of UGT Isoforms in Human Small Bowel and in Caco-2 Cell Monolayers
MF Paine, MB Fisher
Biochemical and Biophysical Research Communications 2000
Influence of Dietary Components on the Gastrointestinal Metabolism and Transport of Drugs
AM Evans
Therapeutic Drug Monitoring 2000
P-Glycoprotein and Bioavailability-Implication of Polymorphism
Y Liu, M Hu
Clinical Chemistry and Laboratory Medicine 2000
Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine
H Suzuki, Y Sugiyama
European Journal of Pharmaceutical Sciences 2000
The role of P-glycoprotein in determining the oral absorption and clearance of the NK2 antagonist, UK-224,671
K Beaumont, A Harper, DA Smith, J Bennett
European Journal of Pharmaceutical Sciences 2000
Drug–Grapefruit Juice Interactions
GC Kane, JJ Lipsky
Mayo Clinic Proceedings 2000
Inhibition Selectivity of Grapefruit Juice Components on Human Cytochromes P450
W Tassaneeyakul, LQ Guo, K Fukuda, T Ohta, Y Yamazoe
Archives of Biochemistry and Biophysics 2000
Gender-Specific Effects on Verapamil Pharmacokinetics and Pharmacodynamics in Humans
ME Krecic-Shepard, CR Barnas, J Slimko, MP Jones, JB Schwartz
The Journal of Clinical Pharmacology 2000
Grapefruit: the last decade acquisitions
B Tirillini
Fitoterapia 2000
Interaction of drugs and Chinese herbs: pharmacokinetic changes of tolbutamide and diazepam caused by extract of Angelica dahurica
K Ishihara, H Kushida, M Yuzurihara, Y Wakui, T Yanagisawa, H Kamei, S Ohmori, M Kitada
The Journal of pharmacy and pharmacology 2000
Pharmacokinetic-Pharmacodynamic Consequences and Clinical Relevance of Cytochrome P450 3A4 Inhibition:
GK Dresser, JD Spence, DG Bailey
Clinical Pharmacokinetics 2000
Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells
M A Gibbs, M T Baillie, D D Shen, K L Kunze, K E Thummel
Pharmaceutical Research 2000
Human cytochromes P450
JA Hasler, R Estabrook, M Murray, I Pikuleva, M Waterman, J Capdevila, V Holla, C Helvig, JR Falck, G Farrell, LS Kaminsky, SD Spivack, E Boitier, P Beaune
Molecular Aspects of Medicine 1999
Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers
RJ Fontana, KS Lown, MF Paine, L Fortlage, RM Santella, JS Felton, MG Knize, A Greenberg, PB Watkins
Gastroenterology 1999
Grapefruit Juice Decreases the Systemic Availability of Itraconazole Capsules in Healthy Volunteers
SR Penzak, PO Gubbins, BJ Gurley, PL Wang, M Saccente
Therapeutic Drug Monitoring 1999
Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components
VA Eagling, L Profit, DJ Back
British Journal of Clinical Pharmacology 1999
The effect of ketoconazole on the jejunal permeability and CYP3A metabolism of (R/S)-verapamil in humans
R Sandström, TW Knutson, L Knutson, B Jansson, H Lennernäs
British Journal of Clinical Pharmacology 1999
Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine
P Damkier, LL Hansen, K Brosen
British Journal of Clinical Pharmacology 1999
Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery
LZ Benet, T Izumi, Y Zhang, JA Silverman, VJ Wacher
Journal of Controlled Release 1999
Transport, metabolism and elimination mechanisms of anti-HIV agents
X Li, WK Chan
Advanced Drug Delivery Reviews 1999
The effects of grapefruit juice on sertraline metabolism: An in vitro and in vivo study
AJ Lee, WK Chan, AF Harralson, J Buffum, BC Bui
Clinical Therapeutics 1999
Beverages, diet, and prevention of kidney stones
DS Goldfarb, FL Coe
American Journal of Kidney Diseases 1999
‘Fire and forget?’ — pharmacological considerations in coronary care
M Bottorff
Atherosclerosis 1999
In vitro and in vivo effects of naringin on cytochrome P450-dependent monooxygenase in mouse liver
YF Ueng, YL Chang, Y Oda, SS Park, JF Liao, MF Lin, CF Chen
Life Sciences 1999
Calcium-Antagonist Drugs
AJ Wood, DR Abernethy, JB Schwartz
New England Journal of Medicine 1999
The effect of paracetamol on peritoneal reflex after single and multiple grapefruit ingestion
I Samojlik, A Rašković, K Đaković-Švajcer, M Mikov, V Jakovljević
Experimental and Toxicologic Pathology 1999
The activity of liver oxidative enzymes after single and multiple grapefruit juice ingestion
K Đaković-Švajcer, I Samojlik, A Rašković, M Popović, V Jakovljević
Experimental and Toxicologic Pathology 1999
Mechanisms underlying variability in response to drug therapy: implications for amiodarone use
DM Roden
The American Journal of Cardiology 1999
Concurrent Administration of the Erythromycin Breath Test (EBT) and Oral Midazolam as In Vivo Probes for CYP3A Activity
J McCrea, T Prueksaritanont, BJ Gertz, A Carides, L Gillen, S Antonello, MJ Brucker, C Miller-Stein, B Osborne, S Waldman
The Journal of Clinical Pharmacology 1999
P-glycoprotein and Drug Therapy in Organ Transplantation
A Lo, GJ Burckart
The Journal of Clinical Pharmacology 1999
Effects of Food on Clinical Pharmacokinetics:
BN Singh
Clinical Pharmacokinetics 1999
Cytochrome P450 3A: Ontogeny and Drug Disposition
SN de Wildt, GL Kearns, JS Leeder, JN van den Anker
Clinical Pharmacokinetics 1999
Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
VJ Wacher, JA Silverman, Y Zhang, LZ Benet
Journal of Pharmaceutical Sciences 1998
Pharmacokinetic interactions between two human immunodeficiency virus protease inhibitors, ritonavir and saquinavir*
A Hsu, GR Granneman, G Cao, L Carothers, T El-Shourbagy, P Baroldi, K Erdman, F Brown, E Sun, JM Leonard
Clinical Pharmacology & Therapeutics 1998
Grapefruit juice—felodipine interaction: Effect of naringin and 6′,7′-dihydroxybergamottin in humans*
DG Bailey, JH Kreeft, C Munoz, DJ Freeman, JR Bend
Clinical Pharmacology & Therapeutics 1998
The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin*
JC Gorski, DR Jones, BD Haehner-Daniels, MA Hamman, EM O'Mara, SD Hall
Clinical Pharmacology & Therapeutics 1998
IN VITRO AND IN VIVO DRUG INTERACTIONS INVOLVING HUMAN CYP3A
KE Thummel, GR Wilkinson
Annual Review of Pharmacology and Toxicology 1998
Influence of diet, vitamins and chemotherapeutic agents on gastrointestinal cancer
J Kolars, C Kurth
Journal of Gastroenterology and Hepatology 1998
Grapefruit juice-drug interactions
DG Bailey, J Malcolm, O Arnold, JD Spence
British Journal of Clinical Pharmacology 1998
Pharmacokinetic interaction between ritonavir and indinavir in healthy volunteers
A Hsu, GR Granneman, G Cao, L Carothers, A Japour, T El-Shourbagy, S Dennis, J Berg, K Erdman, JM Leonard, E Sun
Antimicrobial agents and chemotherapy 1998
Grapefruit juice—simvastatin interaction: Effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors*
JJ Lilja, KT Kivistö, PJ Neuvonen
Clinical Pharmacology & Therapeutics 1998
Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid*
T Kantola, KT Kivistö, PJ Neuvonen
Clinical Pharmacology & Therapeutics 1998
Grapefruit juice substantially increases plasma concentrations of buspirone*
JJ Lilja, KT Kivistö, JT Backman, TS Lamberg, PJ Neuvonen
Clinical Pharmacology & Therapeutics 1998
Mechanism-based inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine
WK Chan, LT Nguyen, VP Miller, RZ harris
Life Sciences 1998
Effect of Grapefruit Juice on the Pharmacokinetics of Microemulsion Cyclosporine and its Metabolite in Healthy Volunteers: Does the Formulation Difference Matter?
YM Ku, DI Min, M Flanigan
The Journal of Clinical Pharmacology 1998
Impact of intraindividual variability of drugs on therapeutic outcomes: lessons from outside transplantation
LZ Benet
Transplantation Proceedings 1998
Inhibition and induction of human cytochrome P450 (CYP) enzymes
O PELKONEN, J MÄEENPÄEÄ, P TAAVITSAINEN, A RAUTIO, H RAUNIO
Xenobiotica 1998
Modulation by Dietary Salt of Verapamil Disposition in Humans
D Darbar, MF Fromm, S DellOrto, RB Kim, HK Kroemer, M Eichelbaum, DM Roden
Circulation 1998
Clinical Interaction Between Grapefruit Juice and Cyclosporine: Is There any Interest for the Hematologists?
G Emilia, G Longo, M Bertesi, G Gandini, L Ferrara, C Valenti
Blood 1998
Jejunal absorption and metabolism of R/S-verapamil in humans
R Sandström, A Karlsson, L Knutson, H Lennernäs
Pharmaceutical Research 1998
Drug Interactions with Grapefruit Juice: Extent, Probable Mechanism and Clinical Relevance
U Fuhr
Drug Safety 1998
Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*
KS Lown, RR Mayo, AB Leichtman, H Hsiao, DK Turgeon, P Schmiedlin-Ren, MB Brown, W Guo, SJ Rossi, LZ Benet, PB Watkins
Clinical Pharmacology & Therapeutics 1997
How Grapefruit Juice Potentiates Drug Bioavailability
B Feldman
Nutrition Reviews 1997
Drug Interactions with Grapefruit Juice:
B Ameer, RA Weintraub
Clinical Pharmacokinetics 1997
Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use
G R Jang, L Z Benet
Journal of Pharmacokinetics and Biopharmaceutics 1997

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