The increase in oral availability of felodipine and other commonly used medications when taken with grapefruit juice has been assumed to be due to inhibition of CYP3A4, a cytochrome P450 that is present in liver and intestine. To evaluate the effect of repeated grapefruit juice ingestion on CYP3A4 expression, 10 healthy men were given 8 oz of grapefruit juice three times a day for 6 d. Before and after receiving grapefruit juice, small bowel and colon mucosal biopsies were obtained endoscopically, oral felodipine kinetics were determined, and liver CYP3A4 activity was measured with the [14C N-methyl] erythromycin breath test in each subject. Grapefruit juice did not alter liver CYP3A4 activity, colon levels of CYP3A5, or small bowel concentrations of P-glycoprotein, villin, CYP1A1, and CYP2D6. In contrast, the concentration of CYP3A4 in small bowel epithelia (enterocytes) fell 62% (P = 0.0006) with no corresponding change in CYP3A4 mRNA levels. In addition, enterocyte concentrations of CYP3A4 measured before grapefruit juice consumption correlated with the increase in Cmax when felodipine was taken with either the 1st or the 16th glass of grapefruit juice relative to water (r = 0. 67, P = 0.043, and r = 0.71, P = 0.022, respectively). We conclude that a mechanism for the effect of grapefruit juice on oral felodipine kinetics is its selective downregulation of CYP3A4 in the small intestine.
K S Lown, D G Bailey, R J Fontana, S K Janardan, C H Adair, L A Fortlage, M B Brown, W Guo, P B Watkins
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Sex and Gender Differences in Pharmacology
V Regitz-Zagrosek |
2012 | |
S-ketamine concentrations are greatly increased by grapefruit juice
MA Peltoniemi, TI Saari, NM Hagelberg, K Laine, PJ Neuvonen, KT Olkkola |
European Journal of Clinical Pharmacology | 2012 |
Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways
W Jiang, M Hu |
RSC Advances | 2012 |
Bioavailability and Bioequivalence
BM Amore |
Encyclopedia of Drug Metabolism and Interactions | 2012 |
Oral Absorption: from Physiology to Regulatory
F Berlioz-Seux |
Encyclopedia of Drug Metabolism and Interactions | 2012 |
Herb-Drug and Food-Drug Interactions
MS Lennard |
Encyclopedia of Drug Metabolism and Interactions | 2012 |
Predicting Human Biotransformation Pathways
S Anderson, D Luffer-Atlas, MP Knadler |
Encyclopedia of Drug Metabolism and Interactions | 2012 |
Effect of Grapefruit Juice and Ritonavir on Pharmacokinetics of Lopinavir in Wistar Rats : EFFECT OF GRAPEFRUIT JUICE ON LOPINAVIR PHARMACOKINETICS
PR Ravi, R Vats, R Thakur, S Srivani, N Aditya |
Phytotherapy Research | 2012 |
Mechanism-Based Inhibition of Recombinant Human Cytochrome P450 3A4 by Tomato Juice Extract
K Sunaga, K Ohkawa, K Nakamura, A Ohkubo, S Harada, T Tsuda |
Biological & Pharmaceutical Bulletin | 2012 |
Safety Evaluation of Fucoidan from Kjellmaniella Crassiforia and Extract from Hypsizigus Marmoreus: Influence on the Activities and Gene Expressions of Rat Hepatic CYPs
H OHNOGI, Y KUDO, S HAYAMI, Y TAKIMOTO, R SUZUKI, N SUZUKI |
Japanese Journal of Complementary and Alternative Medicine | 2012 |
Inclusion of human intravenous study data in new drug applications-impact of the japanese guidance
H Imawaka, M Kusama, K Ito, S Ono, Y Sugiyama |
Journal of Pharmaceutical Sciences | 2012 |
Immunosuppression
IA MacPhee, T Gelder |
Handbook of Renal and Pancreatic Transplantation MacPhee/Handbook of Renal and Pancreatic Transplantation | 2012 |
Phytochemical Modulators of Human Drug Metabolism: Drug Interactions with Fruits, Vegetables, and Botanical Dietary Supplements
B Gurley, KE Fifer, Z Gardner |
Encyclopedia of Drug Metabolism and Interactions | 2012 |
Cochrane Database of Systematic Reviews: Protocols
JJ Ho, AS Adnan, Z Darus, NZ Ismail, HV Rostenberghe, JJ Ho |
Cochrane Database of Systematic Reviews: Protocols | 2012 |
Encyclopedia of Drug Metabolism and Interactions
M Fielden, C Karbowski |
Encyclopedia of Drug Metabolism and Interactions | 2012 |
Metabolism of Drugs and Other Xenobiotics: ANZENBACHER:XENOBIOTICS O-BK
CP Strassburg, S Kalthoff |
Metabolism of Drugs and Other Xenobiotics: ANZENBACHER:XENOBIOTICS O-BK | 2012 |
Effects of Grapefruit and Seville Orange Juices on the Pharmacokinetic Properties of Colchicine in Healthy Subjects
S Wason, JL DiGiacinto, MW Davis |
Clinical Therapeutics | 2012 |
Fruit Juices as Perpetrators of Drug Interactions: The Role of Organic Anion–Transporting Polypeptides
MJ Dolton, BD Roufogalis, AJ McLachlan |
Clinical Pharmacology & Therapeutics | 2012 |
FLAVONOID PHARMACOKINETICS: Methods of Analysis, Preclinical and Clinical Pharmacokinetics, Safety, and Toxicology
JA Yáñez, CM Remsberg, JK Takemoto, KR Vega-Villa, PK Andrews, CL Sayre, SE Martinez, NM Davies |
FLAVONOID PHARMACOKINETICS: Methods of Analysis, Preclinical and Clinical Pharmacokinetics, Safety, and Toxicology | 2012 |
Effect of ciprofloxacin and grapefruit juice on oral pharmacokinetics of riluzole in Wistar rats: CYP 1A2 inhibitors and riluzole kinetics
PR Ravi, R Vats, UR Kora |
Journal of Pharmacy and Pharmacology | 2012 |
Grapefruit-medication interactions: forbidden fruit or avoidable consequences?
DG Bailey, G Dresser, JM Arnold |
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne | 2012 |
Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport
CS Won, NH Oberlies, MF Paine |
Pharmacology & Therapeutics | 2012 |
Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects
MT Holmberg, A Tornio, L Joutsi-Korhonen, M Neuvonen, PJ Neuvonen, R Lassila, M Niemi, JT Backman |
British Journal of Clinical Pharmacology | 2012 |
Phase I Studies of Sirolimus Alone or in Combination with Pharmacokinetic Modulators in Advanced Cancer Patients
EE Cohen, K Wu, C Hartford, M Kocherginsky, KN Eaton, Y Zha, A Nallari, ML Maitland, K Fox-Kay, K Moshier, L House, J Ramirez, SD Undevia, GF Fleming, TF Gajewski, MJ Ratain |
Clinical cancer research | 2012 |
Effect of cranberry dietary supplements with different brands on human CYP3A4 enzyme
Sompon Wanwimolruk, Supaluk Prachayasittikul, Virapong Prachayasittikul, Bouchra Bernichi |
EXCLI J | 2012 |
Ubiquitin-dependent Proteasomal Degradation of Human Liver Cytochrome P450 2E1
YQ Wang, S Guan, P Acharya, DR Koop, Y Liu, M Liao, AL Burlingame, MA Correia |
The Journal of biological chemistry | 2011 |
A Critical Analysis of the Interplay between Cytochrome P450 3A and P-Glycoprotein: Recent Insights from Knockout and Transgenic Mice
RA van Waterschoot, AH Schinkel, EE Scott |
Pharmacological reviews | 2011 |
Oral Bioavailability
R Singh, M Hu |
Oral Bioavailability | 2011 |
Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery
AC Freire, AW Basit, R Choudhary, CW Piong, HA Merchant |
International Journal of Pharmaceutics | 2011 |
Individual variability in the disposition of and response to clopidogrel: Pharmacogenomics and beyond
HG Xie, JJ Zou, ZY Hu, JJ Zhang, F Ye, SL Chen |
Pharmacology & Therapeutics | 2011 |
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné |
Advances in Immunology Volume 110 | 2011 |
Different influences on tacrolimus pharmacokinetics by coadministrations of zhi ke and zhi shi in rats
SP Lin, PP Wu, YC Hou, SY Tsai, MJ Wang, SH Fang, PD Chao |
Evidence-based complementary and alternative medicine : eCAM | 2011 |
Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren
T Tapaninen, PJ Neuvonen, M Niemi |
British Journal of Clinical Pharmacology | 2011 |
Diverse approaches for the enhancement of oral drug bioavailability
P Fasinu, V Pillay, VM Ndesendo, LC du Toit, YE Choonara |
Biopharmaceutics & Drug Disposition | 2011 |
Modulation of CYP1A1 activity by a Ginkgo biloba extract in the human intestinal Caco-2 cells
L Ribonnet, A Callebaut, I Nobels, ML Scippo, YJ Schneider, SD Saeger, L Pussemier, Y Larondelle |
Toxicology Letters | 2011 |
Potential of anin vitrotoolbox combined with exposure data as a first step for the risk assessment of dietary chemical contaminants
L Ribonnet, E der Heiden, I Nobels, A Chaumont, AS Remacle, SD Saeger, YJ Schneider, ML Scippo, R Blust, L Pussemier, Y Larondelle |
Food Additives & Contaminants: Part A | 2011 |
Simulation of Population Variability in Pharmacokinetics
J Yang |
Systems Biology in Drug Discovery and Development Young/Systems Bio in Drug Discovery | 2011 |
The effect of grapefruit juice on drug disposition
MJ Hanley, P Cancalon, WW Widmer, DJ Greenblatt |
Expert Opinion on Drug Metabolism & Toxicology | 2011 |
Ubiquitin-dependent Proteasomal Degradation of Human Liver Cytochrome P450 2E1: IDENTIFICATION OF SITES TARGETED FOR PHOSPHORYLATION AND UBIQUITINATION
YQ Wang, S Guan, P Acharya, DR Koop, Y Liu, M Liao, AL Burlingame, MA Correia |
The Journal of biological chemistry | 2011 |
The basics of pharmacokinetics in prescribing and clinical practice
EU Khan |
Nurse Prescribing | 2011 |
薬剤師からみた健康食品・サプリメント
C Ono |
Juntendo Medical Journal | 2011 |
Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir
RA van Waterschoot, R Heine, E Wagenaar, CM van der Kruijssen, RW Rooswinkel, AD Huitema, JH Beijnen, AH Schinkel |
British Journal of Pharmacology | 2010 |
Differences in the pharmacokinetics of Cyp3a substrates in TSOD and streptozotocin-induced diabetic mice
T Kudo, T Toda, T Ushiki, K Ohi, N Ikarashi, W Ochiai, K Sugiyama |
Xenobiotica | 2010 |
Regional Distribution of Cytochrome P450 mRNA Expression in the Liver and Small Intestine of Cynomolgus Monkeys
Y NAKANISHI, A MATSUSHITA, K MATSUNO, K IWASAKI, M UTOH, C NAKAMURA, Y UNO |
Drug Metabolism and Pharmacokinetics | 2010 |
The influence of Nifadin®, Niprisan® and Niprd/92/001/1-1 (AM-1) on the pharmacokinetics of metronidazole in rats
MT Bakare-Odunola, KB Mustapha, M Garba, OO Obodozie, IS Enemali |
European Journal of Drug Metabolism and Pharmacokinetics | 2010 |
The use of isolated enterocytes to study Phase I intestinal drug metabolism: validation with rat and pig intestine
P Bonnefille, Z Sezgin-Bayindir, H Belkhelfa, C Arellano, P Gandia, J Woodley, G Houin |
Fundamental & Clinical Pharmacology | 2010 |
Effects of Ingestion of Grapefruit Juice or Grapefruit on the Hypotensive Effect and Plasma Concentrations of Dihydropyridine Calcium Antagonists (Amlodipine and Nifedipine): A Case Study
K Nakagawa, T Goto |
Clinical and Experimental Hypertension | 2010 |
Grapefruit Juice Greatly Reduces the Plasma Concentrations of the OATP2B1 and CYP3A4 Substrate Aliskiren
T Tapaninen, PJ Neuvonen, M Niemi |
Clinical Pharmacology & Therapeutics | 2010 |
A rapid ultra-performance liquid chromatography/tandem mass spectrometric methodology for thein vitroanalysis of Pooled and Cocktail cytochrome P450 assays
PG Alden, RS Plumb, MD Jones, PD Rainville, D Shave |
Rapid Communications in Mass Spectrometry | 2010 |
Grapefruit Juice Enhances the Exposure to Oral Oxycodone
TH Nieminen, NM Hagelberg, TI Saari, M Neuvonen, PJ Neuvonen, K Laine, KT Olkkola |
Basic & Clinical Pharmacology & Toxicology | 2010 |
Influence of Purple Grape Juice in Cyclosporine Bioavailability
VL Oliveira-Freitas, TD Costa, RC Manfro, LB Cruz, G Schwartsmann |
Journal of Renal Nutrition | 2010 |
Isolation and Identification of Intestinal CYP3A Inhibitors from Cranberry (Vaccinium macrocarpon) using Human Intestinal Microsomes
E Kim, A Sy-Cordero, TN Graf, SJ Brantley, MF Paine, NH Oberlies |
Planta medica | 2010 |
Fruit juice inhibition of uptake transport: a new type of food–drug interaction
DG Bailey |
British Journal of Clinical Pharmacology | 2010 |
A dangerous fruit juice
S Agosti, L Casalino, G Bertero, A Barsotti, C Brunelli, S Morelloni |
The American Journal of Emergency Medicine | 2010 |
Drug interactions with grapefruit
ZB Z., NB Z., V Bojanic |
Medicinski pregled | 2010 |
INFLUENCE OF DIETARY SUBSTANCES ON INTESTINAL DRUG METABOLISM AND TRANSPORT
CS Won, NH Oberlies, MF Paine |
Current drug metabolism | 2010 |
Ambient tonicity and intestinal cytochrome CYP3A
AI Chuang, S Ito |
Expert Opinion on Drug Metabolism & Toxicology | 2010 |
Effect of Grapefruit Juice on the Pharmacokinetics of Nilotinib in Healthy Participants
OQ Yin, N Gallagher, A Li, W Zhou, R Harrell, H Schran |
The Journal of Clinical Pharmacology | 2010 |
xPharm: The Comprehensive Pharmacology Reference
A Vinh |
xPharm: The Comprehensive Pharmacology Reference | 2010 |
A Pharmacokinetic Model for Evaluating the Impact of Hepatic and Intestinal First-Pass Loss of Saquinavir in the Rat
R Lledó-García, A Nácher, VG Casabó, M Merino-Sanjuán |
Drug Metabolism and Disposition | 2010 |
Grapefruit-Drug Interactions:
K Seden, L Dickinson, S Khoo, D Back |
Drugs | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
How important is intestinal cytochrome P450 3A metabolism?
AE van Herwaarden, RA van Waterschoot, AH Schinkel |
Trends in Pharmacological Sciences | 2009 |
Cytochrome P450-mediated metabolism in the human gut wall
K Thelen, JB Dressman |
Journal of Pharmacy and Pharmacology | 2009 |
Variable Inhibitory Effect of Different Brands of Commercial Herbal Supplements on Human Cytochrome P-450 CYP3A4
S Wanwimolruk, K Wong, P Wanwimolruk |
Drug Metabolism and Drug Interactions | 2009 |
Medikamenteninteraktionen in der Geriatrie
A Storka, J Pleiner |
Wiener Medizinische Wochenschrift | 2009 |
Effect of phytomedicines, AM-1, niprisan® and nifadin on the pharmacokinetics of chloroquine in rats
KB Mustapha, MT Bakare-Odunola, M Garba, OO Obodozie, IS Enemali, US Inyan |
European Journal of Drug Metabolism and Pharmacokinetics | 2009 |
Impact of CYP3A5 and CYP3A4 gene polymorphisms on dose requirement of calcineurin inhibitors, cyclosporine and tacrolimus, in renal allograft recipients of North India
R Singh, A Srivastava, R Kapoor, RK Sharma, RD Mittal |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2009 |
CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells
T Sergent, I Dupont, EV der Heiden, ML Scippo, L Pussemier, Y Larondelle, YJ Schneider |
Toxicology Letters | 2009 |
Genetic Influences on the Pharmacokinetics of Orally and Intravenously Administered Digoxin as Exhibited by Monozygotic Twins
AL Birkenfeld, J Jordan, U Hofmann, A Busjahn, G Franke, N Krüger, S Igel, T Mürdter, S Drescher, S Shi, S Engeli, M Schwab, M Eichelbaum, FC Luft, MF Fromm |
Clinical Pharmacology & Therapeutics | 2009 |
Drug—drug interactions resulting from inhibition of cytochrome P450s
K Yoshinari |
Folia Pharmacologica Japonica | 2009 |
Serum cyclosporine level and orange juice in pediatric renal-transplanted patients
H Sorkhi, AA Moghadamnia, F Oaliaee, M PourAmir, AR Firoozjahi, AA Pasha, MR Goodarzi |
Pediatric Transplantation | 2009 |
Significantly Altered Systemic Exposure to Atorvastatin Acid Following Gastric Bypass Surgery in Morbidly Obese Patients
IB Skottheim, K Stormark, H Christensen, GS Jakobsen, J Hjelmesæth, T Jenssen, JL Reubsaet, R Sandbu, A Åsberg |
Clinical Pharmacology & Therapeutics | 2009 |
Dose–response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles
K Strauch, U Lutz, N Bittner, WK Lutz |
Food and Chemical Toxicology | 2009 |
Human clearance prediction: shifting the paradigm
T Lavé, K Chapman, P Goldsmith, M Rowland |
Expert Opinion on Drug Metabolism & Toxicology | 2009 |
The grapefruit: an old wine in a new glass? Metabolic and cardiovascular perspectives
PM Owira, JA Ojewole |
CARDIOVASC J AFR | 2009 |
Grapefruit juice alters plasma sertraline levels after single ingestion of sertraline in healthy volunteers
N Ueda, R Yoshimura, W Umene-Nakano, A Ikenouchi-Sugita, H Hori, K Hayashi, Y Kodama, J Nakamura |
World Journal of Biological Psychiatry | 2009 |
Enzyme- and Transporter-Based Drug-Drug Interactions
KS Pang, AD Rodrigues, RM Peter |
2009 | |
Handbook of Drug-Nutrient Interactions
JI Boullata, VT Armenti |
2009 | |
RETRACTION: Hepatic CYP3A Suppression by High Concentrations of Proteasomal Inhibitors: A Consequence of Endoplasmic Reticulum (ER) Stress Induction, Activation of RNA-Dependent Protein Kinase-Like ER-Bound Eukaryotic Initiation Factor 2α (eIF2α)-Kinase (PERK) and General Control Nonderepressible-2 eIF2α Kinase (GCN2), and Global Translational Shutoff
P Acharya, JC Engel, MA Correia |
Molecular pharmacology | 2009 |
Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver
RA van Waterschoot, RW Rooswinkel, E Wagenaar, CM van der Kruijssen, AE van Herwaarden, AH Schinkel |
The FASEB Journal | 2008 |
Reply
J Bommer, T Heinrich, H Heidt, V Hafner, E Jenetzky, I Walter-Sack, G Mikus |
Nephrology Dialysis Transplantation | 2008 |
Relationship between Lipophilicities of 1,4-Dihydropyridine Derivatives and Pharmacokinetic Interaction Strengths with Grapefruit Juice
Y UESAWA, K MOHRI |
YAKUGAKU ZASSHI | 2008 |
Examining sex-related differences in enteric itraconazole metabolism in healthy adults using grapefruit juice
PO Gubbins, BJ Gurley, DK Williams, SR Penzak, SA McConnell, AM Franks, M Saccente |
European Journal of Clinical Pharmacology | 2008 |
Species differences inin vitro andin vivo small intestinal metabolism of CYP3A substrates
H Komura, M Iwaki |
Journal of Pharmaceutical Sciences | 2008 |
Review Article: Cytochrome P450 enzyme, and transport protein mediated herb–drug interactions in renal transplant patients: Grapefruit juice, St John's Wort – and beyond! (Review Article)
R Nowack |
Nephrology | 2008 |
Comparative Evaluation of 12 Immature Citrus Fruit Extracts for the Inhibition of Cytochrome P450 Isoform Activities
T Fujita, A Kawase, T Niwa, N Tomohiro, M Masuda, H Matsuda, M Iwaki |
Biological & Pharmaceutical Bulletin | 2008 |
In vivoassessment of herb–drug interactions: Possible utility of a pharmacogenetic approach?
B Tomlinson, M Hu, VW Lee |
Molecular Nutrition & Food Research | 2008 |
Influence of fruit juices on drug disposition: discrepancies betweenin vitroand clinical studies
D Farkas, DJ Greenblatt |
Expert Opinion on Drug Metabolism & Toxicology | 2008 |
Potential role of intestinal first-pass metabolism in the prediction of drug–drug interactions
A Galetin, M Gertz, JB Houston |
Expert Opinion on Drug Metabolism & Toxicology | 2008 |
Clinically Significant Grapefruit Juice-Drug Interactions
WW McCloskey, K Zaiken, RR Couris |
Nutrition Today | 2008 |
Laboratory diet profoundly alters gene expression and confounds genomic analysis in mouse liver and lung
CD Kozul, AP Nomikos, TH Hampton, LA Warnke, JA Gosse, JC Davey, JE Thorpe, BP Jackson, MA Ihnat, JW Hamilton |
Chemico-Biological Interactions | 2008 |
Molecular and cellular effects of food contaminants and secondary plant components and their plausible interactions at the intestinal level
T Sergent |
Food and Chemical Toxicology | 2008 |
Effects of dietary salt on the expression of drug transporters, cytochrome P4503a, and nuclear receptors in rats
HJ Kang, IS Song, SS Lee, MA Yoo, JG Shin |
Xenobiotica | 2008 |
Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability
H de Waterbeemd, B Testa |
Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability | 2008 |
Further characterization of a furanocoumarin-free grapefruit juice on drug disposition: studies with cyclosporine
MF Paine, WW Widmer, SN Pusek, KL Beavers, AB Criss, J Snyder, PB Watkins |
The American journal of clinical nutrition | 2008 |
Advances in Bioactivation Research
A Elfarra |
2008 | |
Effect of Grapefruit Juice, Naringin, Naringenin, and Bergamottin on the Intestinal Carrier-Mediated Transport of Talinolol in Rats
WV de Castro, S Mertens-Talcott, H Derendorf, V Butterweck |
Journal of Agricultural and Food Chemistry | 2008 |
Intestinal Drug Transporter Expression and the Impact of Grapefruit Juice in Humans
H Glaeser, DG Bailey, GK Dresser, JC Gregor, UI Schwarz, JS McGrath, E Jolicoeur, W Lee, BF Leake, RG Tirona, RB Kim |
Clinical Pharmacology & Therapeutics | 2007 |
Medicinal importance of grapefruit juice and its interaction with various drugs
J Kiani, SZ Imam |
Nutrition Journal | 2007 |
Prospective study of grapefruit intake and risk of breast cancer in postmenopausal women: the Multiethnic Cohort Study
KR Monroe, SP Murphy, LN Kolonel, MC Pike |
British Journal of Cancer | 2007 |
Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97?
S Faouzi, KF Medzihradszky, C Hefner, JJ Maher, MA Correia |
Biochemistry | 2007 |
Effects of clarithromycin and grapefruit juice on the pharmacokinetics of glibenclamide
JJ Lilja, M Niemi, H Fredrikson, PJ Neuvonen |
British Journal of Clinical Pharmacology | 2007 |
Clinical relevance of the small intestine as an organ of drug elimination: drug–fruit juice interactions
MF Paine, NH Oberlies |
Expert Opinion on Drug Metabolism & Toxicology | 2007 |
Naringin is a Major and Selective Clinical Inhibitor of Organic Anion-Transporting Polypeptide 1A2 (OATP1A2) in Grapefruit Juice
DG Bailey, GK Dresser, BF Leake, RB Kim |
Clinical Pharmacology & Therapeutics | 2007 |
Effect of tangerine juice on cyclosporine levels in renal transplant children
H Sorkhi, AA Moghadamnia, F Oaliaee, M PourAmir, AR Firoozjahi, AA Pasha, MR Goodarzi |
Pediatric Nephrology | 2007 |
Effects of Daily Ingestion of Cranberry Juice on the Pharmacokinetics of Warfarin, Tizanidine, and Midazolam—Probes of CYP2C9, CYP1A2, and CYP3A4
JJ Lilja, JT Backman, PJ Neuvonen |
Clinical Pharmacology & Therapeutics | 2007 |
Interaction of Herbal Constituents with Cytochrome P450 Enzymes
E Yarnell, K Abascal |
Alternative and Complementary Therapies | 2007 |
Cellular proteolytic systems in P450 degradation: evolutionary conservation fromSaccharomycescerevisiaeto mammalian liver
MA Correia, M Liao |
Expert Opinion on Drug Metabolism & Toxicology | 2007 |
Side Effects of Drugs Annual
T Vial, J Descotes, F Braun, M Behrend |
Side Effects of Drugs Annual | 2007 |
Principles of Clinical Pharmacology
CS Stika, MC Frederiksen |
Principles of Clinical Pharmacology | 2007 |
Drug-Induced Liver Disease, Second Edition
M Pirmohamed, S Leeder |
Drug-Induced Liver Disease, Second Edition | 2007 |
The Additive Effects of the Active Component of Grapefruit Juice (Naringenin) and Antiarrhythmic Drugs on HERG Inhibition
C Lin, X Ke, V Ranade, J Somberg |
Cardiology | 2007 |
Decreased Expression of Breast Cancer Resistance Protein in the Duodenum in Patients with Obstructive Cholestasis
C Zimmermann, P Hruz, H Gutmann, L Terracciano, U Beuers, F Lehmann, C Beglinger, J Drewe |
Digestion | 2006 |
Stereoselective interaction of manidipine and grapefruit juice: a new twist on an old tale
B Tomlinson, MS Chow |
British Journal of Clinical Pharmacology | 2006 |
Effects of cranberry juice on nifedipine pharmacokinetics in rats
Y Uesawa, K Mohri |
Journal of Pharmacy and Pharmacology | 2006 |
Major determinant factors of the extent of interaction between grapefruit juice and calcium channel antagonists
A Ohnishi, H Ohtani, Y Sawada |
British Journal of Clinical Pharmacology | 2006 |
Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects
T Uno, T Ohkubo, S Motomura, K Sugawara |
British Journal of Clinical Pharmacology | 2006 |
Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics
SW Grimm, NM Richtand, HR Winter, KR Stams, SB Reele |
British Journal of Clinical Pharmacology | 2006 |
Interaction between grapefruit juice and hypnotic drugs: comparison of triazolam and quazepam
K Sugimoto, N Araki, M Ohmori, K Harada, Y Cui, S Tsuruoka, A Kawaguchi, A Fujimura |
European Journal of Clinical Pharmacology | 2006 |
UV-Irradiated Grapefruit Juice Loses Pharmacokinetic Interaction with Nifedipine in Rats
Y Uesawa, K Mohri |
Biological & Pharmaceutical Bulletin | 2006 |
Delayed Effect of Grapefruit Juice on Pharmacokinetics and Pharmacodynamics of Tacrolimus in a Living-Donor Liver Transplant Recipient
S FUKATSU, M FUKUDO, S MASUDA, I YANO, T KATSURA, Y OGURA, F OIKE, Y TAKADA, K INUI |
Drug Metabolism and Pharmacokinetics | 2006 |
NARINGIN DOES NOT ALTER CAFFEINE PHARMACOKINETICS, ENERGY EXPENDITURE, OR CARDIOVASCULAR HAEMODYNAMICS IN HUMANS FOLLOWING CAFFEINE CONSUMPTION
TL Ballard, FT Halaweish, CL Stevermer, P Agrawal, MD Vukovich |
Clinical and Experimental Pharmacology and Physiology | 2006 |
Active Drug Transport of Immunosuppressants
U Christians, T Strom, YL Zhang, W Steudel, V Schmitz, S Trump, M Haschke |
Therapeutic Drug Monitoring | 2006 |
Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors
H Blume, F Donath, A Warnke, BS Schug |
Drug Safety | 2006 |
Docosahexaenoic acid (DHA) inhibits saquinavir metabolism in-vitro and enhances its bioavailability in rats
V Hirunpanich, H Sato |
Journal of Pharmacy and Pharmacology | 2006 |
The Use of Heat Treatment to Eliminate Drug Interactions Due to Grapefruit Juice
Y Uesawa, K Mohri |
Biological & Pharmaceutical Bulletin | 2006 |
VARIATIONS IN CONTENT OF ACTIVE INGREDIENTS CAUSING DRUG INTERACTIONS IN GRAPEFRUIT JUICE PRODUCTS SOLD IN CALIFORNIA
S Wanwimolruk, PV Marquez |
Drug Metabolism and Drug Interactions | 2006 |
Active Drug Transport of Immunosuppressants: New Insights for Pharmacokinetics and Pharmacodynamics
U Christians, T Strom, YL Zhang, W Steudel, V Schmitz, S Trump, M Haschke |
Therapeutic Drug Monitoring | 2006 |
Drugs and the Pharmaceutical Sciences: Scientific and Regulatory Perspectives
I Zadezensky, H Derendorf, V Butterweck, S Mertens-Talcott, WD Castro |
Drugs and the Pharmaceutical Sciences | 2006 |
Drug-Drug Interaction After Single Oral Doses of the Furanocoumarin Methoxsalen and Cyclosporine
M Rheeders, M Bouwer, TC Goosen |
The Journal of Clinical Pharmacology | 2006 |
Grapefruit-Drug Interactions: Can Interactions With Drugs Be Avoided?
SU Mertens-Talcott, I Zadezensky, WV de Castro, H Derendorf, V Butterweck |
The Journal of Clinical Pharmacology | 2006 |
A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice–felodipine interaction
MF Paine, WW Widmer, HL Hart, SN Pusek, KL Beavers, AB Criss, SS Brown, BF Thomas, PB Watkins |
The American journal of clinical nutrition | 2006 |
The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 C3435T polymorphisms and gender on the urinary excretion of the metabolites of the H1-receptor antihistamine ebastine: a pilot study
G Gervasini, S Vizcaino, JA Carrillo, MJ Caballero, J Benitez |
British Journal of Clinical Pharmacology | 2006 |
Lopinavir/Ritonavir Induces the Hepatic Activity of Cytochrome P450 Enzymes CYP2C9, CYP2C19, and CYP1A2 But Inhibits the Hepatic and Intestinal Activity of CYP3A as Measured by a Phenotyping Drug Cocktail in Healthy Volunteers
RF Yeh, VE Gaver, KB Patterson, NL Rezk, F Baxter-Meheux, MJ Blake, JJ Eron, CE Klein, JC Rublein, AD Kashuba |
Journal of acquired immune deficiency syndromes (1999) | 2006 |
Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors:
H Blume, F Donath, A Warnke, BS Schug |
Drug Safety | 2006 |
Oral tolerance
AM Faria, HL Weiner |
Immunological Reviews | 2005 |
Nutrition and Disease Prevention
K Imaizumi |
Soy in Health and Disease Prevention | 2005 |
Food-Drug Synergy and Safety
A Bree, P Galan, L Mennen |
Food-Drug Synergy and Safety | 2005 |
Cytochromes P450 and MDR1 mRNA expression along the human gastrointestinal tract
M Thörn, N Finnström, S Lundgren, A Rane, L Lööf |
British Journal of Clinical Pharmacology | 2005 |
Impact of citrus soft drinks relative to grapefruit juice on ciclosporin disposition
UI Schwarz, PE Johnston, DG Bailey, RB Kim, G Mayo, A Milstone |
British Journal of Clinical Pharmacology | 2005 |
Effects of grapefruit juice on the pharmacokinetics of acebutolol
JJ Lilja, K Raaska, PJ Neuvonen |
British Journal of Clinical Pharmacology | 2005 |
Effects of grapefruit juice on the absorption of levothyroxine
JJ Lilja, K Laitinen, PJ Neuvonen |
British Journal of Clinical Pharmacology | 2005 |
A Higher Dose Requirement of Tacrolimus in Active Crohn's Disease May Be Related to a High Intestinal P-Glycoprotein Content
AL Buchman, MF Paine, A Wallin, SS Ludington |
Digestive Diseases and Sciences | 2005 |
Effects of orange juice on the pharmacokinetics of atenolol
JJ Lilja, K Raaska, PJ Neuvonen |
European Journal of Clinical Pharmacology | 2005 |
Effect of Grapefruit Juice Volume on the Reduction of Fexofenadine Bioavailability: Possible Role of Organic Anion Transporting Polypeptides*
GK Dresser, RB Kim, DG Bailey |
Clinical Pharmacology & Therapeutics | 2005 |
Intestinal Expression and Metabolic Activity of the CYP3A Subfamily in Female Rats
T Aiba, M Yoshinaga, K Ishida, Y Takehara, Y Hashimoto |
Biological & Pharmaceutical Bulletin | 2005 |
Effects of Sweetie Juice on Nifedipine Pharmacokinetics in Rats
Y UESAWA, K MOHRI |
YAKUGAKU ZASSHI | 2005 |
Inhibition of Human Intestinal Wall Metabolism by Macrolide Antibiotics: Effect of Clarithromycin on Cytochrome P450 3A4/5 Activity and Expression*
AG Pinto, YH Wang, N Chalasani, T Skaar, D Kolwankar, JC Gorski, S Liangpunsakul, MA Hamman, M Arefayene, SD Hall |
Clinical Pharmacology & Therapeutics | 2005 |
Health-related Interactions of Phytochemicals
MA Lila, I Raskin |
Journal of Food Science | 2005 |
Functional interactions between P-glycoprotein and CYP3A in drug metabolism
U Christians, V Schmitz, M Haschke |
Expert Opinion on Drug Metabolism & Toxicology | 2005 |
Diltiazem inhibits human intestinal cytochrome P450 3A (CYP3A) activity in vivo without altering the expression of intestinal mRNA or protein
AG Pinto, J Horlander, N Chalasani, M Hamman, A Asghar, D Kolwankar, SD Hall |
British Journal of Clinical Pharmacology | 2005 |
Progress in Pharmaceutical and Biomedical Analysis
A Ghosal, R Ramanathan, NS Kishnani, SK Chowdhury, KB Alton |
Progress in Pharmaceutical and Biomedical Analysis | 2005 |
The Influence of Age and Sex on the Clearance of Cytochrome P450 3A Substrates:
MM Cotreau, LL von Moltke, DJ Greenblatt |
Clinical Pharmacokinetics | 2005 |
Undesirable Effects of Citrus Juice on the Pharmacokinetics of Drugs: Focus on Recent Studies
M Saito, M Hirata-Koizumi, M Matsumoto, T Urano, R Hasegawa |
Drug Safety | 2005 |
Cytochrome P450
PR de Montellano |
Cytochrome P450 | 2005 |
What's the Scoop with Grapefruit?
ES Sterling, KM Smith |
Orthopedics | 2005 |
CITRUS JUICES INHIBIT THE FUNCTION OF HUMAN ORGANIC ANION-TRANSPORTING POLYPEPTIDE OATP-B
H Satoh, F Yamashita, M Tsujimoto, H Murakami, N Koyabu, H Ohtani, Y Sawada |
Drug Metabolism and Disposition | 2005 |
Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin
JJ Lilja, M Neuvonen, PJ Neuvonen |
British Journal of Clinical Pharmacology | 2004 |
CYP3A in horse intestines
E Tydén, L Olsén, J Tallkvist, P Larsson, H Tjälve |
Toxicology and Applied Pharmacology | 2004 |
Effects of grapefruit juice on pharmacokinetics of atorvastatin and pravastatin in Japanese
I Fukazawa, N Uchida, E Uchida, H Yasuhara |
British Journal of Clinical Pharmacology | 2004 |
Screening of Furanocoumarin Derivatives in Citrus Fruits by Enzyme-Linked Immunosorbent Assay
T Saita, H Fujito, M Mori |
Biological & Pharmaceutical Bulletin | 2004 |
Impact of inter-individual differences in drug metabolism and pharmacokinetics on safety evaluation
JL Dorne |
Fundamental and Clinical Pharmacology | 2004 |
Effect of fruit juices on the oral bioavailability of fexofenadine in rats
AV Kamath, M Yao, Y Zhang, S Chong |
Journal of Pharmaceutical Sciences | 2004 |
Effects of Continuous Ingestion of Green Tea or Grape Seed Extracts on the Pharmacokinetics of Midazolam
M NISHIKAWA, N ARIYOSHI, A KOTANI, I ISHII, H NAKAMURA, H NAKASA, M IDA, H NAKAMURA, N KIMURA, M KIMURA, A HASEGAWA, F KUSU, S OHMORI, K NAKAZAWA, M KITADA |
Drug Metabolism and Pharmacokinetics | 2004 |
Influence of Hepatic and Intestinal Cytochrome P4503A Activity on the Acute Disposition and Effects of Oral Transmucosal Fentanyl Citrate
ED Kharasch, D Whittington, C Hoffer |
Anesthesiology | 2004 |
FOOD-DRUG INTERACTIONS VIA HUMAN CYTOCHROME P450 3A (CYP3A)
K Fujita |
Drug Metabolism and Drug Interactions | 2004 |
Influence of Grapefruit Juice on the Systemic Availability of Itraconazole Oral Solution in Healthy Adult Volunteers
PO Gubbins, SA McConnell, BJ Gurley, TK Fincher, AM Franks, DK Williams, SR Penzak, M Saccente |
Pharmacotherapy | 2004 |
Differences in Drug Pharmacokinetics Between East Asians and Caucasians and the Role of Genetic Polymorphisms
K Kim, JA Johnson, H Derendorf |
The Journal of Clinical Pharmacology | 2004 |
Pharmacokinetics in older persons
BJ Cusack |
The American journal of geriatric pharmacotherapy | 2004 |
Drug interactions in dentistry
EV Hersh, PA Moore |
The Journal of the American Dental Association | 2004 |
Complementary and Alternative Cardiovascular Medicine
RA Stein, MC Oz |
2004 | |
Handbook of Drug Interactions
A Mozayani, LP Raymon |
2004 | |
Interactions Between Grapefruit Juice and Cardiovascular Drugs:
DG Bailey, GK Dresser |
American Journal Cardiovascular Drugs | 2004 |
Clinical Pharmacokinetics of Thalidomide:
SK Teo, WA Colburn, WG Tracewell, KA Kook, DI Stirling, MS Jaworsky, MA Scheffler, SD Thomas, OL Laskin |
Clinical Pharmacokinetics | 2004 |
Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis Volume 3
DZ DArgenio |
2004 | |
Beverages in Nutrition and Health
T Wilson, NJ Temple |
2004 | |
Applications of Pharmacokinetic Principles in Drug Development
R Krishna |
2004 | |
Contributions of CYP3A4, P-glycoprotein, and Serum Protein Binding to the Intestinal First-Pass Extraction of Saquinavir
SJ Mouly, MF Paine, PB Watkins |
The Journal of pharmacology and experimental therapeutics | 2004 |
DO MEN AND WOMEN DIFFER IN PROXIMAL SMALL INTESTINAL CYP3A OR P-GLYCOPROTEIN EXPRESSION?
MF Paine, SS Ludington, ML Chen, PW Stewart, SM Huang, PB Watkins |
Drug Metabolism and Disposition | 2004 |
TWO MAJOR GRAPEFRUIT JUICE COMPONENTS DIFFER IN INTESTINAL CYP3A4 INHIBITION KINETIC AND BINDING PROPERTIES
MF Paine, AB Criss, PB Watkins |
Drug Metabolism and Disposition | 2004 |
Two Major Grapefruit Juice Components Differ in Time to Onset of Intestinal CYP3A4 Inhibition
MF Paine, AB Criss, PB Watkins |
The Journal of pharmacology and experimental therapeutics | 2004 |
The Grapefruit Juice Effect Is Not Limited to Cytochrome P450 (P450) 3A4: Evidence for Bergamottin-Dependent Inactivation, Heme Destruction, and Covalent Binding to Protein in P450s 2B6 and 3A5
H Lin, UM Kent, PF Hollenberg |
The Journal of pharmacology and experimental therapeutics | 2004 |
Factors Responsible for the Variability of Saquinavir Absorption: Studies Using an Instrumented Dog Model
N Tam-Zaman, YK Tam, S Tawfik, H Wiltshire |
Pharmaceutical Research | 2004 |
INDUCTION OFDRUG-METABOLIZINGENZYMES: A Path to the Discovery of Multiple Cytochromes P450*
AH Conney |
Annual Review of Pharmacology and Toxicology | 2003 |
Phytochemical functional foods
F Virgili, C Scaccini, L Packer, G Rimbach |
Phytochemical functional foods | 2003 |
The effects of fruit juices on drug disposition: a new model for drug interactions
GK Dresser, DG Bailey |
European Journal of Clinical Investigation | 2003 |
Variable expression of CYP and Pgp genes in the human small intestine
M Lindell, MO Karlsson, H Lennernas, L Pahlman, MA Lang |
European Journal of Clinical Investigation | 2003 |
Interactions of grapefruit juice and cardiovascular medications: A potential risk of toxicity
GE Lim, T Li, HS Buttar |
Experimental and clinical cardiology | 2003 |
HUMANEXTRAHEPATICCYTOCHROMESP450: Function in Xenobiotic Metabolism and Tissue-Selective Chemical Toxicity in the Respiratory and Gastrointestinal Tracts*
X Ding, LS Kaminsky |
Annual Review of Pharmacology and Toxicology | 2003 |
Gender-Specific Implications for Cardiovascular Medication Use in the Elderly
JB Schwartz |
Cardiology in Review | 2003 |
Dietary Supplements of Plant Origin
J Cott |
Dietary Supplements of Plant Origin | 2003 |
Antihypertensive therapy: special focus on drug interactions
R Maas, RH Böger |
Expert Opinion on Drug Safety | 2003 |
Inhibitory Effects of Citrus Fruits on Cytochrome P450 3A (CYP3A) Activity in Humans
K Fujita, M Hidaka, N Takamura, K Yamasaki, T Iwakiri, M Okumura, H Kodama, M Yamaguchi, T Ikenoue, K Arimori |
Biological & Pharmaceutical Bulletin | 2003 |
Simple and sensitive high-performance liquid chromatography method for simultaneous determination of urinary free cortisol and 6β-hydroxycortisol in routine practice
E Rouits, M Boisdron-Celle, A Morel, E Gamelin |
Journal of Chromatography B | 2003 |
Grapefruit Juice-fluvoxamine Interaction
H Hori, R Yoshimura, N Ueda, S Eto, K Shinkai, S Sakata, O Ohmori, T Terao, J Nakamura |
Journal of Clinical Psychopharmacology | 2003 |
Nature, nurture and human disease
A Chakravarti, P Little |
Nature | 2003 |
Drug interactions: a review and update
BE Byrne |
Endodontic Topics | 2003 |
Effects of Grapefruit Juice on Intestinal P-glycoprotein: Evaluation Using Digoxin in Humans
RB Parker, CR Yates, JE Soberman, SC Laizure |
Pharmacotherapy | 2003 |
In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products
BC Foster, S Vandenhoek, J Hana, A Krantis, MH Akhtar, M Bryan, JW Budzinski, A Ramputh, JT Arnason |
Phytomedicine | 2003 |
Drugs and the Pharmaceutical Sciences
D Thompson |
Drugs and the Pharmaceutical Sciences | 2003 |
Exposure-Dependent Inhibition of Intestinal and Hepatic CYP3A4 In Vivo by Grapefruit Juice
ML Veronese, LP Gillen, JP Burke, EP Dorval, WW Hauck, E Pequignot, SA Waldman, HE Greenberg |
The Journal of Clinical Pharmacology | 2003 |
Sho-saiko-to and Saiko-keisi-to, the traditional Chinese and Japanese herbal medicines, altered hepatic drug-metabolizing enzymes in mice and rats when administered orally for a long time
M Nose, M Tamura, N Ryu, H Mizukami, Y Ogihara |
Journal of Pharmacy and Pharmacology | 2003 |
Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery and Development
K Bachmann, S Wrighton, B Ring |
Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery and Development | 2003 |
Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man
RA Mirghani, Ö Ericsson, G Tybring, LL Gustafsson, L Bertilsson |
European Journal of Clinical Pharmacology | 2003 |
Measurement of hepatic and intestinal CYP3A4 and PGP activity by combined po + iv [ 14 C]erythromycin breath and urine test
WP Lemahieu, BD Maes, Y Ghoos, P Rutgeerts, K Verbeke, Y Vanrenterghem |
AJP Gastrointestinal and Liver Physiology | 2003 |
Food–drug interaction: grapefruit juice augments drug bioavailability—mechanism, extent and relevance
A Dahan, H Altman |
European Journal of Clinical Nutrition | 2003 |
Effects of liquid and freeze-dried grapefruit juice on the pharmacokinetics of praziquantel and its metabolite 4′-hydroxy praziquantel in beagle dogs
M Giorgi, V Meucci, E Vaccaro, G Mengozzi, M Giusiani, G Soldani |
Pharmacological research : the official journal of the Italian Pharmacological Society | 2003 |
Management of Calcium Channel Antagonist Overdose:
SD Salhanick, MW Shannon |
Drug Safety | 2003 |
Dietary Effects on Drug Metabolism and Transport:
RZ Harris, GR Jang, S Tsunoda |
Clinical Pharmacokinetics | 2003 |
Factors Affecting the Clinical Development of Cytochrome P450 3A Substrates:
MA Gibbs, NA Hosea |
Clinical Pharmacokinetics | 2003 |
MODELING OF INTESTINAL DRUG ABSORPTION: ROLES OF TRANSPORTERS AND METABOLIC ENZYMES (FOR THE GILLETTE REVIEW SERIES)
KS Pang |
Drug Metabolism and Disposition | 2003 |
THE SMALL INTESTINE AS A XENOBIOTIC-METABOLIZING ORGAN
LS Kaminsky, QY Zhang |
Drug Metabolism and Disposition | 2003 |
50 Years of DNA
J Clayton, C Dennis |
2003 | |
Modulation of digoxin transport across Caco-2 cell monolayers by citrus fruit juices: lime, lemon, grapefruit, and pummelo
Jianguo Xu, Mei Lin Go, Lee-Yong Lim |
Pharmaceutical Research | 2003 |
Drug–phytochemical interactions
C Ioannides |
Inflammopharmacology | 2003 |
P-glycoprotein increases from proximal to distal regions of human small intestine
Stéphane Mouly, Mary F Paine |
Pharmaceutical Research | 2003 |
Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?
S Wanwimolruk, MF Paine, SN Pusek, PB Watkins |
British Journal of Clinical Pharmacology | 2002 |
An in vitro examination of the impact of polyethylene glycol 400, Pluronic P85, and vitamin E d-alpha-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine
BM Johnson, WN Charman, CJ Porter |
AAPS PharmSci | 2002 |
Intestinal first pass metabolism of midazolam in liver cirrhosis --effect of grapefruit juice
V Andersen, N Pedersen, NE Larsen, J Sonne, S Larsen |
British Journal of Clinical Pharmacology | 2002 |
Interaction between grapefruit juice and praziquantel in humans
N Castro, H Jung, R Medina, D González-Esquivel, M Lopez, J Sotelo |
Antimicrobial agents and chemotherapy | 2002 |
Grapefruit juice: potential drug interactions
J Maskalyk |
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne | 2002 |
Drug-nutrient interaction in clinical nutrition
LN Chan |
Current Opinion in Clinical Nutrition and Metabolic Care | 2002 |
Amino acids in SRS1 and SRS6 are critical for furanocoumarin metabolism by CYP6B1v1, a cytochrome P450 monooxygenase
JS Chen, MR Berenbaum, MA Schuler |
Insect Molecular Biology | 2002 |
On the assessment of effects of food on the pharmacokinetics of drugs in early development
Z Li, NN Vachharajani, R Krishna |
Biopharmaceutics & Drug Disposition | 2002 |
Effects of Single and Repeated Treatment with Itraconazole on the Pharmacokinetics of Midazolam in Rats
Y SAWADA, S TAKEDOMI, H MATSUO, K YAMANO, T IGA, H OHTANI |
Drug Metabolism and Pharmacokinetics | 2002 |
Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity
L Zou, MR Harkey, GL Henderson |
Life Sciences | 2002 |
Mechanisms of Clinically Relevant Drug Interactions Associated with Tacrolimus
U Christians, W Jacobsen, LZ Benet, A Lampen |
Clinical Pharmacokinetics | 2002 |
A Mechanistic Approach to Understanding the Factors Affecting Drug Absorption: A Review of Fundamentals
MN Martinez, GL Amidon |
The Journal of Clinical Pharmacology | 2002 |
Grapefruit juice potentiates the anti-inflammatory effects of diclofenac on the carrageenan-induced rat’s paw oedema
AA Mahgoub |
Pharmacological Research | 2002 |
Pharmacokinetic interactions between herbal remedies and medicinal drugs
C Ioannides |
Xenobiotica | 2002 |
Investigation of the Coordinated Functional Activities of Cytochrome P450 3A4 and P‐Glycoprotein in Limiting the Absorption of Xenobiotics in Caco‐2 Cells
CD Tran, P Timmins, BR Conway, WJ Irwin |
Journal of Pharmaceutical Sciences | 2002 |
Effect of Oral Ketoconazole on First‐pass Effect of Nifedipine After Oral Administration in Dogs
M Kuroha, H Kayaba, S Kishimoto, WF Khalil, M Shimoda, E Kokue |
Journal of Pharmaceutical Sciences | 2002 |
Tropical Review: Zonisamide in Pediatric Epilepsy: Review of the Japanese Experience
TA Glauser, JM Pellock |
Journal of child neurology | 2002 |
Understanding drug interactions
B Maher, M Pirmohamed |
Nursing and Residential Care | 2002 |
Unmasking the Dynamic Interplay between Intestinal P-Glycoprotein and CYP3A4
CL Cummins, W Jacobsen, LZ Benet |
The Journal of pharmacology and experimental therapeutics | 2002 |
Effects of Bergamottin on Human and Monkey Drug-Metabolizing Enzymes in Primary Cultured Hepatocytes
YH Wen, J Sahi, E Urda, S Kulkarni, K Rose, X Zheng, JF Sinclair, H Cai, SC Strom, VE Kostrubsky |
Drug Metabolism and Disposition | 2002 |
The Effect of Bergamottin on Diazepam Plasma Levels and P450 Enzymes in Beagle Dogs
J Sahi, EL Reyner, JN Bauman, K Gueneva-Boucheva, JE Burleigh, VH Thomas |
Drug Metabolism and Disposition | 2002 |
Intestinal Metabolism Promotes Regional Differences in Apical Uptake of Indinavir: Coupled Effect of P-Glycoprotein and Cytochrome P450 3A on Indinavir Membrane Permeability in Rat
LY Li, GL Amidon, JS Kim, T Heimbach, F Kesisoglou, JT Topliss, D Fleisher |
The Journal of pharmacology and experimental therapeutics | 2002 |
Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates
Run Tian, Noriko Koyabu, Hitomi Takanaga, Hirotami Matsuo, Hisakazu Ohtani, Yasufumi Sawada |
Pharmaceutical Research | 2002 |
Mechanisms of Clinically Relevant Drug Interactions Associated with Tacrolimus:
U Christians, W Jacobsen, LZ Benet, A Lampen |
Clinical Pharmacokinetics | 2002 |
INTERINDIVIDUALVARIABILITY ININHIBITION ANDINDUCTION OFCYTOCHROMEP450 ENZYMES
JH Lin, AY Lu |
Annual Review of Pharmacology and Toxicology | 2001 |
Strategies to overcome simultaneous P-glycoprotein mediated efflux and CYP3A4 mediated metabolism of drugs
J Patel, AK Mitra |
Pharmacogenomics | 2001 |
Therapeutic potential of dietary phase 2 enzyme inducers in ameliorating diseases that have an underlying inflammatory component
BH Juurlink |
Canadian Journal of Physiology and Pharmacology | 2001 |
Drug Interactions With Grapefruit Juice: An Update
DJ Greenblatt, KC Patki, LL von Moltke, RI Shader |
Journal of Clinical Psychopharmacology | 2001 |
Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice
Z Desta, KT Kivistö, JJ Lilja, JT Backman, N Soukhova, PJ Neuvonen, DA Flockhart |
British Journal of Clinical Pharmacology | 2001 |
EFFECT OF GRAPEFRUIT JUICE ON URINARY LITHOGENICITY
DS Goldfarb, JR Asplin |
The Journal of Urology | 2001 |
Predicting the impact of physiological and biochemical processes on oral drug bioavailability
B Agoram, WS Woltosz, MB Bolger |
Advanced Drug Delivery Reviews | 2001 |
Race but Not Age Affects Erythromycin Breath Test Results in Older Hypertensive Men
JB Schwartz |
The Journal of Clinical Pharmacology | 2001 |
Effect of Grapefruit Juice on Pharmacokinetics of Microemulsion Cyclosporine in African American Subjects Compared with Caucasian Subjects: Does Ethnic Difference Matter?
M Lee, DI Min, YM Ku, M Flanigan |
The Journal of Clinical Pharmacology | 2001 |
Nutrition et médicaments: mise au point sur les aspects pharmacocinétiques
S Saivin, G Houin |
Revue Française des Laboratoires | 2001 |
Drug-Nutrient Interactions in Transplant Recipients
LN Chan |
JPEN. Journal of parenteral and enteral nutrition | 2001 |
Effect of grapefruit juice on Sandimmun Neoral® absorption among stable renal allograft recipients
C Bistrup, FT Nielsen, UE Jeppesen, H Dieperink |
Nephrology Dialysis Transplantation | 2001 |
The Gut as a Barrier to Drug Absorption: Combined Role of Cytochrome P450 3A and P-Glycoprotein
Y Zhang, LZ Benet |
Clinical Pharmacokinetics | 2001 |
Pharmacokinetic Aspects of Treating Infections in the Intensive Care Unit: Focus on Drug Interactions
F Pea, M Furlanut |
Clinical Pharmacokinetics | 2001 |
Drug Interactions in Infectious Diseases
SC Piscitelli, KA Rodvold |
2001 | |
Medical Challenges for the New Millennium
SN Willich, S Elm |
2001 | |
Herb-Drug Interactions: Focus on Pharmacokinetics
JM Cott |
CNS Spectrums | 2001 |
Lipids, lipophilic drugs, and oral drug delivery?Some emerging concepts
WN Charman |
Journal of Pharmaceutical Sciences | 2000 |
The Effect of Rifampin Treatment on Intestinal Expression of Human MRP Transporters
MF Fromm, HM Kauffmann, P Fritz, O Burk, HK Kroemer, RW Warzok, M Eichelbaum, W Siegmund, D Schrenk |
The American Journal of Pathology | 2000 |
Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4
A Ohnishi, H Matsuo, S Yamada, H Takanaga, S Morimoto, Y Shoyama, H Ohtani, Y Sawada |
British Journal of Pharmacology | 2000 |
Formation of omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by grapefruit juice
W Tassaneeyakul, S Vannaprasaht, Y Yamazoe |
British Journal of Clinical Pharmacology | 2000 |
Pharmacokinetic analysis of felodipine-grapefruit juice interaction based on an irreversible enzyme inhibition model
H Takanaga, A Ohnishi, H Matsuo, H Murakami, H Sata, K Kuroda, A Urae, S Higuchi, Y Sawada |
British Journal of Clinical Pharmacology | 2000 |
Modulation of oral bioavailability of anticancer drugs: from mouse to man
JH Schellens, MM Malingré, CM Kruijtzer, HA Bardelmeijer, O Tellingen, AH Schinkel, JH Beijnen |
European Journal of Pharmaceutical Sciences | 2000 |
Immunochemical Identification of UGT Isoforms in Human Small Bowel and in Caco-2 Cell Monolayers
MF Paine, MB Fisher |
Biochemical and Biophysical Research Communications | 2000 |
Influence of Dietary Components on the Gastrointestinal Metabolism and Transport of Drugs
AM Evans |
Therapeutic Drug Monitoring | 2000 |
P-Glycoprotein and Bioavailability-Implication of Polymorphism
Y Liu, M Hu |
Clinical Chemistry and Laboratory Medicine | 2000 |
Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine
H Suzuki, Y Sugiyama |
European Journal of Pharmaceutical Sciences | 2000 |
The role of P-glycoprotein in determining the oral absorption and clearance of the NK2 antagonist, UK-224,671
K Beaumont, A Harper, DA Smith, J Bennett |
European Journal of Pharmaceutical Sciences | 2000 |
Drug–Grapefruit Juice Interactions
GC Kane, JJ Lipsky |
Mayo Clinic Proceedings | 2000 |
Inhibition Selectivity of Grapefruit Juice Components on Human Cytochromes P450
W Tassaneeyakul, LQ Guo, K Fukuda, T Ohta, Y Yamazoe |
Archives of Biochemistry and Biophysics | 2000 |
Gender-Specific Effects on Verapamil Pharmacokinetics and Pharmacodynamics in Humans
ME Krecic-Shepard, CR Barnas, J Slimko, MP Jones, JB Schwartz |
The Journal of Clinical Pharmacology | 2000 |
Grapefruit: the last decade acquisitions
B Tirillini |
Fitoterapia | 2000 |
Interaction of drugs and Chinese herbs: pharmacokinetic changes of tolbutamide and diazepam caused by extract of Angelica dahurica
K Ishihara, H Kushida, M Yuzurihara, Y Wakui, T Yanagisawa, H Kamei, S Ohmori, M Kitada |
The Journal of pharmacy and pharmacology | 2000 |
Pharmacokinetic-Pharmacodynamic Consequences and Clinical Relevance of Cytochrome P450 3A4 Inhibition:
GK Dresser, JD Spence, DG Bailey |
Clinical Pharmacokinetics | 2000 |
Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells
M A Gibbs, M T Baillie, D D Shen, K L Kunze, K E Thummel |
Pharmaceutical Research | 2000 |
Human cytochromes P450
JA Hasler, R Estabrook, M Murray, I Pikuleva, M Waterman, J Capdevila, V Holla, C Helvig, JR Falck, G Farrell, LS Kaminsky, SD Spivack, E Boitier, P Beaune |
Molecular Aspects of Medicine | 1999 |
Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers
RJ Fontana, KS Lown, MF Paine, L Fortlage, RM Santella, JS Felton, MG Knize, A Greenberg, PB Watkins |
Gastroenterology | 1999 |
Grapefruit Juice Decreases the Systemic Availability of Itraconazole Capsules in Healthy Volunteers
SR Penzak, PO Gubbins, BJ Gurley, PL Wang, M Saccente |
Therapeutic Drug Monitoring | 1999 |
Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components
VA Eagling, L Profit, DJ Back |
British Journal of Clinical Pharmacology | 1999 |
The effect of ketoconazole on the jejunal permeability and CYP3A metabolism of (R/S)-verapamil in humans
R Sandström, TW Knutson, L Knutson, B Jansson, H Lennernäs |
British Journal of Clinical Pharmacology | 1999 |
Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine
P Damkier, LL Hansen, K Brosen |
British Journal of Clinical Pharmacology | 1999 |
Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery
LZ Benet, T Izumi, Y Zhang, JA Silverman, VJ Wacher |
Journal of Controlled Release | 1999 |
Transport, metabolism and elimination mechanisms of anti-HIV agents
X Li, WK Chan |
Advanced Drug Delivery Reviews | 1999 |
The effects of grapefruit juice on sertraline metabolism: An in vitro and in vivo study
AJ Lee, WK Chan, AF Harralson, J Buffum, BC Bui |
Clinical Therapeutics | 1999 |
Beverages, diet, and prevention of kidney stones
DS Goldfarb, FL Coe |
American Journal of Kidney Diseases | 1999 |
‘Fire and forget?’ — pharmacological considerations in coronary care
M Bottorff |
Atherosclerosis | 1999 |
In vitro and in vivo effects of naringin on cytochrome P450-dependent monooxygenase in mouse liver
YF Ueng, YL Chang, Y Oda, SS Park, JF Liao, MF Lin, CF Chen |
Life Sciences | 1999 |
Calcium-Antagonist Drugs
AJ Wood, DR Abernethy, JB Schwartz |
New England Journal of Medicine | 1999 |
The effect of paracetamol on peritoneal reflex after single and multiple grapefruit ingestion
I Samojlik, A Rašković, K Đaković-Švajcer, M Mikov, V Jakovljević |
Experimental and Toxicologic Pathology | 1999 |
The activity of liver oxidative enzymes after single and multiple grapefruit juice ingestion
K Đaković-Švajcer, I Samojlik, A Rašković, M Popović, V Jakovljević |
Experimental and Toxicologic Pathology | 1999 |
Mechanisms underlying variability in response to drug therapy: implications for amiodarone use
DM Roden |
The American Journal of Cardiology | 1999 |
Concurrent Administration of the Erythromycin Breath Test (EBT) and Oral Midazolam as In Vivo Probes for CYP3A Activity
J McCrea, T Prueksaritanont, BJ Gertz, A Carides, L Gillen, S Antonello, MJ Brucker, C Miller-Stein, B Osborne, S Waldman |
The Journal of Clinical Pharmacology | 1999 |
P-glycoprotein and Drug Therapy in Organ Transplantation
A Lo, GJ Burckart |
The Journal of Clinical Pharmacology | 1999 |
Effects of Food on Clinical Pharmacokinetics:
BN Singh |
Clinical Pharmacokinetics | 1999 |
Cytochrome P450 3A: Ontogeny and Drug Disposition
SN de Wildt, GL Kearns, JS Leeder, JN van den Anker |
Clinical Pharmacokinetics | 1999 |
Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
VJ Wacher, JA Silverman, Y Zhang, LZ Benet |
Journal of Pharmaceutical Sciences | 1998 |
Pharmacokinetic interactions between two human immunodeficiency virus protease inhibitors, ritonavir and saquinavir*
A Hsu, GR Granneman, G Cao, L Carothers, T El-Shourbagy, P Baroldi, K Erdman, F Brown, E Sun, JM Leonard |
Clinical Pharmacology & Therapeutics | 1998 |
Grapefruit juice—felodipine interaction: Effect of naringin and 6′,7′-dihydroxybergamottin in humans*
DG Bailey, JH Kreeft, C Munoz, DJ Freeman, JR Bend |
Clinical Pharmacology & Therapeutics | 1998 |
The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin*
JC Gorski, DR Jones, BD Haehner-Daniels, MA Hamman, EM O'Mara, SD Hall |
Clinical Pharmacology & Therapeutics | 1998 |
IN VITRO AND IN VIVO DRUG INTERACTIONS INVOLVING HUMAN CYP3A
KE Thummel, GR Wilkinson |
Annual Review of Pharmacology and Toxicology | 1998 |
Influence of diet, vitamins and chemotherapeutic agents on gastrointestinal cancer
J Kolars, C Kurth |
Journal of Gastroenterology and Hepatology | 1998 |
Grapefruit juice-drug interactions
DG Bailey, J Malcolm, O Arnold, JD Spence |
British Journal of Clinical Pharmacology | 1998 |
Pharmacokinetic interaction between ritonavir and indinavir in healthy volunteers
A Hsu, GR Granneman, G Cao, L Carothers, A Japour, T El-Shourbagy, S Dennis, J Berg, K Erdman, JM Leonard, E Sun |
Antimicrobial agents and chemotherapy | 1998 |
Grapefruit juice—simvastatin interaction: Effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors*
JJ Lilja, KT Kivistö, PJ Neuvonen |
Clinical Pharmacology & Therapeutics | 1998 |
Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid*
T Kantola, KT Kivistö, PJ Neuvonen |
Clinical Pharmacology & Therapeutics | 1998 |
Grapefruit juice substantially increases plasma concentrations of buspirone*
JJ Lilja, KT Kivistö, JT Backman, TS Lamberg, PJ Neuvonen |
Clinical Pharmacology & Therapeutics | 1998 |
Mechanism-based inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine
WK Chan, LT Nguyen, VP Miller, RZ harris |
Life Sciences | 1998 |
Effect of Grapefruit Juice on the Pharmacokinetics of Microemulsion Cyclosporine and its Metabolite in Healthy Volunteers: Does the Formulation Difference Matter?
YM Ku, DI Min, M Flanigan |
The Journal of Clinical Pharmacology | 1998 |
Impact of intraindividual variability of drugs on therapeutic outcomes: lessons from outside transplantation
LZ Benet |
Transplantation Proceedings | 1998 |
Inhibition and induction of human cytochrome P450 (CYP) enzymes
O PELKONEN, J MÄEENPÄEÄ, P TAAVITSAINEN, A RAUTIO, H RAUNIO |
Xenobiotica | 1998 |
Modulation by Dietary Salt of Verapamil Disposition in Humans
D Darbar, MF Fromm, S DellOrto, RB Kim, HK Kroemer, M Eichelbaum, DM Roden |
Circulation | 1998 |
Clinical Interaction Between Grapefruit Juice and Cyclosporine: Is There any Interest for the Hematologists?
G Emilia, G Longo, M Bertesi, G Gandini, L Ferrara, C Valenti |
Blood | 1998 |
Jejunal absorption and metabolism of R/S-verapamil in humans
R Sandström, A Karlsson, L Knutson, H Lennernäs |
Pharmaceutical Research | 1998 |
Drug Interactions with Grapefruit Juice: Extent, Probable Mechanism and Clinical Relevance
U Fuhr |
Drug Safety | 1998 |
Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*
KS Lown, RR Mayo, AB Leichtman, H Hsiao, DK Turgeon, P Schmiedlin-Ren, MB Brown, W Guo, SJ Rossi, LZ Benet, PB Watkins |
Clinical Pharmacology & Therapeutics | 1997 |
How Grapefruit Juice Potentiates Drug Bioavailability
B Feldman |
Nutrition Reviews | 1997 |
Drug Interactions with Grapefruit Juice:
B Ameer, RA Weintraub |
Clinical Pharmacokinetics | 1997 |
Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use
G R Jang, L Z Benet |
Journal of Pharmacokinetics and Biopharmaceutics | 1997 |