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Research Article Free access | 10.1172/JCI119081

Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3.

M Harrela, H Koistinen, J Kaprio, M Lehtovirta, J Tuomilehto, J Eriksson, L Toivanen, M Koskenvuo, P Leinonen, R Koistinen, and M Seppälä

Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.

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Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.

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Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.

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Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.

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Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.

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Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.

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Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.

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Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.

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Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.

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Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.

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Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.

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Published December 1, 1996 - More info

Published in Volume 98, Issue 11 on December 1, 1996
J Clin Invest. 1996;98(11):2612–2615. https://doi.org/10.1172/JCI119081.
© 1996 The American Society for Clinical Investigation
Published December 1, 1996 - Version history
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Abstract

We assessed the magnitude of the genetic component in the variation of circulating levels of insulin-like growth factors I and II (IGF-I and IGF-II), and their binding proteins IGFBP-1 and IGFBP-3 by measuring their serum concentrations in 32 monozygotic and 47 dizygotic adult twin pairs of the same sex. The intrapair correlation for the IGF-I levels was r = 0.41 (P < 0.009) for monozygotic twins and r = 0.12 (P < 0.22) for dizygotic twins. For the IGF-II concentration the intrapair correlations were r = 0.66 (P < 0.0001) for the monozygotic and r = 0.34 (P < 0.01) for the dizygotic twins. No significant intrapair correlation was found for IGFBP-1 levels in either group. The correlations for IGFBP-3 concentration were r = 0.65 (P < 0.0001) and r = 0.23 (P < 0.06) for monozygotic and dizygotic twins, respectively. Women had higher IGF-II levels than men (635+/-175 vs. 522+/-144 microg/liter; P < 0.0001) and IGFBP-3 levels were also higher in women compared with men (5441+/-1018 vs. 4496+/-1084 microg/liter; P < 0.001). The proportion of variance attributable to genetic effects was 38% for the IGF-I concentration, 66% for the IGF-II concentration, and 60% for the IGFBP-3 concentration. No significant heritability was found for the IGFBP-1 concentrations. Our results show that, in adults, there is a substantial genetic contribution responsible for interindividual variation of the circulating levels of IGF-I, IGF-II, and IGFBP-3, but not for the IGFBP-1 levels.

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