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Citations to this article

Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.
P Xia, … , M R Jirousek, G L King
P Xia, … , M R Jirousek, G L King
Published November 1, 1996
Citation Information: J Clin Invest. 1996;98(9):2018-2026. https://doi.org/10.1172/JCI119006.
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Research Article Article has an altmetric score of 6

Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.

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Abstract

Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen which mediates its effects by binding to tyrosine kinase receptors. We have characterized the VEGF-activated intracellular signal transduction pathway in bovine aortic endothelial cells and correlated this to its mitogenic effects. VEGF induced concentration- and time-dependent increases in protein kinase C (PKC) activation with a maximum of 2.2-fold above the basal level at 5 x 10(-10) M within 10 min as measured both by in situ and translocation assays. Immunoblotting analysis of PKC isoforms in cytosolic and membrane fractions indicated that after VEGF stimulation the content of Ca(2+)-sensitive PKC isoforms (alpha and betaII) was increased in the membrane fractions, whereas no changes were observed for PKC isoforms delta and epsilon. The stimulation of PKC activity by VEGF was preceded by the activation of phospholipase Cgamma (PLCgamma). This was demonstrated by parallel increases in PLCgamma tyrosine phosphorylation, [3H]inositol phosphate production, and [3H]arachidonic acid-labeled diacylglycerol formation in bovine aortic endothelial cells. In addition, VEGF increased phosphatidylinositol 3-kinase activity 2.1-fold which was inhibited by wortmannin, a phosphatidylinositol 3-kinase inhibitor, without decreasing the VEGF-induced increase in PKC activity or endothelial cell growth. Interestingly, genistein, a tyrosine kinase inhibitor, and GFX or H-7, PKC inhibitors, abolished both VEGF-induced PKC activation and endothelial cell proliferation. VEGF's mitogenic effect was inhibited by a PKC isoform beta-selective inhibitor, LY333531, in a concentration-dependent manner. In contrast, antisense PKC-alpha oligonucleotides enhanced VEGF-stimulated cell growth with a simultaneous decrease of 70% in PKC-alpha protein content. Thus, VEGF appears to mediate its mitogenic effects partly through the activation of the PLCgamma and PKC pathway, involving predominately PKC-beta isoform activation in endothelial cells.

Authors

P Xia, L P Aiello, H Ishii, Z Y Jiang, D J Park, G S Robinson, H Takagi, W P Newsome, M R Jirousek, G L King

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Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K)
Y Maeno, Q Li, K Park, C Rask-Madsen, B Gao, M Matsumoto, Y Liu, IH Wu, MF White, EP Feener, GL King
The Journal of biological chemistry 2011
The role of AMP-activated protein kinase in the functional effects of vascular endothelial growth factor-A and -B in human aortic endothelial cells
JA Reihill, MA Ewart, IP Salt
Vascular cell 2011
Role of protein kinase C β and vascular endothelial growth factor receptor in malignant pleural mesothelioma: Therapeutic implications and the usefulness of Caenorhabditis elegans model organism
S Loganathan, R Kanteti, SS Siddiqui, E El-Hashani, M Tretiakova, H Vigneswaran, G Cervantes, V Natarajan, AN Husain, EE Vokes, HL Kindler, R Salgia
Journal of carcinogenesis 2011
SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration
M Thill, MJ Berna, F Kunst, H Wege, NV Strunnikova, N Gordiyenko, R Grierson, G Richard, KG Csaky
Molecular vision 2011
Signal transduction by vascular endothelial growth factor receptors
S Koch, S Tugues, X Li, L Gualandi, L Claesson‑Welsh
Biochemical Journal 2011
Soluble Vascular Endothelial Growth Factor Receptor-2 and Inflammatory Factors in Macular Edema with Branch Retinal Vein Occlusion
H Noma, H Funatsu, T Mimura, S Eguchi, S Hori
American Journal of Ophthalmology 2011
EFFECT OF RUBOXISTAURIN (RBX) ON VISUAL ACUITY DECLINE OVER A 6-YEAR PERIOD WITH CESSATION AND REINSTITUTION OF THERAPY
MJ Sheetz, LP Aiello, N Shahri, MD Davis, KA Kles, RP Danis
Retina 2011
Targeting PKC-β II and PKB Connection: Design of Dual Inhibitors
K Jain, D Ajay, ME Sobhia
Molecular Informatics 2011
Comparably accelerated vascularization by preincorporation of aortic fragments and mesenchymal stem cells in implanted tissue engineering constructs
P Schumann, C See, A Kampmann, D Lindhorst, F Tavassol, H Kokemüller, KH Bormann, NC Gellrich, M Rücker
Journal of Biomedical Materials Research Part A 2011
Diabetic retinopathy – An update
AA Alghadyan
Saudi Journal of Ophthalmology 2011
Ca 2+ Influx through Reverse Mode Na + /Ca 2+ Exchange Is Critical for Vascular Endothelial Growth Factor-mediated Extracellular Signal-regulated Kinase (ERK) 1/2 Activation and Angiogenic Functions of Human Endothelial Cells
P Andrikopoulos, A Baba, T Matsuda, MB Djamgoz, MM Yaqoob, SA Eccles
The Journal of biological chemistry 2011
Angiogenic Functions of Voltage-gated Na + Channels in Human Endothelial Cells: MODULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) SIGNALING
P Andrikopoulos, SP Fraser, L Patterson, Z Ahmad, H Burcu, D Ottaviani, JK Diss, C Box, SA Eccles, MB Djamgoz
The Journal of biological chemistry 2011
RACK1 Regulates VEGF/Flt1-mediated Cell Migration via Activation of a PI3K/Akt Pathway
F Wang, M Yamauchi, M Muramatsu, T Osawa, R Tsuchida, M Shibuya
The Journal of biological chemistry 2011
Review of therapeutic advances in diabetic retinopathy
C Chen, CP Shah
Therapeutic Advances in Endocrinology and Metabolism 2011
Visual Dysfunction in Diabetes
J Tombran-Tink, CJ Barnstable, TW Gardner
2011
Activation of protein kinase C isoforms and its impact on diabetic complications
P Geraldes, GL King
Circulation research 2010
Protein kinase Calpha: disease regulator and therapeutic target
O Konopatskaya, AW Poole
Trends in Pharmacological Sciences 2010
Human genetics of diabetic retinopathy: current perspectives
DP Ng
Journal of Ophthalmology 2010
Vascular endothelial growth factor stimulates protein kinase C II expression in chronic lymphocytic leukemia cells
ST Abrams, BR Brown, M Zuzel, JR Slupsky
Blood 2010
Prediction of diabetic retinopathy: role of oxidative stress and relevance of apoptotic biomarkers
M Al-Shabrawey, S Smith
The EPMA Journal 2010
Intermittent high glucose enhances cell proliferation and VEGF expression in retinal endothelial cells: the role of mitochondrial reactive oxygen species
J Sun, Y Xu, S Sun, Y Sun, X Wang
Molecular and Cellular Biochemistry 2010
Novel therapeutic agents for B-cell lymphoma: developing rational combinations
CB Reeder, SM Ansell
Blood 2010
Differential subcellular expression of protein kinase C betaII in breast cancer: correlation with breast cancer subtypes
Y Gökmen-Polar, R Mehta, S Tuzmen, S Mousses, MA Thorat, KL Sanders, D Turbin, S Leung, DG Huntsman, GW Sledge, S Badve
Breast Cancer Research and Treatment 2010
Scutellarin promotes in vitro angiogenesis in human umbilical vein endothelial cells
ZX Gao, DY Huang, HX Li, LN Zhang, YH Lv, HD Cui, JH Zheng
Biochemical and Biophysical Research Communications 2010
Ruboxistaurin, a PKCβ inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt
S Nakamura, Y Chikaraishi, K Tsuruma, M Shimazawa, H Hara
Experimental Eye Research 2010
RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma
Y Zhang, X Jiang, X Qin, D Ye, Z Yi, M Liu, O Bai, W Liu, X Xie, Z Wang, J Fang, Y Chen
Oncogene 2010
Identification of VEGF receptor-2 tyrosine phosphorylation sites involved in VEGF-mediated endothelial platelet-activating factor synthesis
A Rechka, PE Neagoe, JP Gratton, MG Sirois
Canadian Journal of Physiology and Pharmacology 2010
Vitamins & Hormones
KJ Hare, FK Knop
Vitamins & Hormones 2010
Role of protein kinase C in diabetic complications
GL King, N Das-Evcimen
Expert Review of Endocrinology & Metabolism 2010
Protein Kinase C in Cancer Signaling and Therapy
MG Kazanietz
2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells
C Caron, K Spring, M Laramée, C Chabot, M Cloutier, H Gu, I Royal
Cellular Signalling 2009
New Role for the Protein Tyrosine Phosphatase DEP-1 in Akt Activation and Endothelial Cell Survival
C Chabot, K Spring, JP Gratton, M Elchebly, I Royal
Molecular and cellular biology 2009
Combination of enzastaurin and pemetrexed inhibits cell growth and induces apoptosis of chemoresistant ovarian cancer cells regulating extracellular signal-regulated kinase 1/2 phosphorylation
K Bräutigam, DO Bauerschlag, MT Weigel, J Biernath-Wüpping, T Bauknecht, N Arnold, N Maass, I Meinhold-Heerlein
Translational oncology 2009
Vascular endothelial growth factor upregulates expression of annexin A2 in vitro and in a mouse model of ischemic retinopathy
SH Zhao, LN Huang, JH Wu, Y Zhang, DY Pan, X Liu
Molecular vision 2009
Eye vessels saved by rescuing their pericyte partners
D Antonetti
Nature Medicine 2009
PPAR  agonists inhibit angiogenesis by suppressing PKC - and CREB-mediated COX-2 expression in the human endothelium
E Scoditti, M Massaro, MA Carluccio, A Distante, C Storelli, RD Caterina
Cardiovascular Research 2009
Differences in the temporal expression of regulatory growth factors during choroidal neovascular development
W Hu, MH Criswell, SL Fong, CJ Temm, G Rajashekhar, TL Cornell, MA Clauss
Experimental Eye Research 2009
Synergistic effect of Sorafenib and Sunitinib with Enzastaurin, a selective protein kinase C inhibitor in renal cell carcinoma cell lines
UM Vogl, W Berger, M Micksche, C Pirker, W Lamm, O Pichelmeyer, CC Zielinski, M Schmidinger
Cancer Letters 2009
VEGFs and receptors involved in angiogenesis versus lymphangiogenesis
M Lohela, M Bry, T Tammela, K Alitalo
Current Opinion in Cell Biology 2009
Ruboxistaurin: PKC-β inhibition for complications of diabetes
RP Danis, MJ Sheetz
Expert Opinion on Pharmacotherapy 2009
Distinct signaling pathways confer different vascular responses to VEGF 121 and VEGF 165
Y Zhang, Y Zhang, M Furumura, Y Zhang, M Furumura, E Morita
Growth Factors 2008
Differential Regulation of VEGF Signaling by PKC-α and PKC-ε in Endothelial Cells
C Rask-Madsen, GL King
Arteriosclerosis, thrombosis, and vascular biology 2008
Complications of type 1 diabetes: new molecular findings
A Stirban, P Rösen, D Tschoepe
Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine 2008
VEGF-A splicing: the key to anti-angiogenic therapeutics?
SJ Harper, DO Bates
Nature reviews. Cancer 2008
Protein kinase C beta in malignant pleural mesothelioma
L Faoro, S Loganathan, M Westerhoff, R Modi, AN Husain, M Tretiakova, T Seiwert, HL Kindler, EE Vokes, R Salgia
Anti-Cancer Drugs 2008
Enzastaurin inhibits tumours sensitive and resistant to anti-EGFR drugs
T Gelardi, R Caputo, V Damiano, G Daniele, S Pepe, F Ciardiello, M Lahn, R Bianco, G Tortora
British Journal of Cancer 2008
Enzastaurin, an inhibitor of PKCbeta, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells
AC Spalding, BD Zeitlin, K Wilder-Romans, ME Davis, JE Nor, TS Lawrence, E Ben-Josef
Translational oncology 2008
Diabetic retinopathy: an update
R Singh, K Ramasamy, C Abraham, V Gupta, A Gupta
Indian journal of ophthalmology 2008
Hypericin inhibits pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy
A Higuchi, H Yamada, E Yamada, N Jo, M Matsumura
Molecular vision 2008
Protein kinase C beta inhibitors: a new therapeutic target for diabetic nephropathy and vascular complications
S Budhiraja, J Singh
Fundamental & Clinical Pharmacology 2008
Scutellarein inhibits hypoxia- and moderately-high glucose-induced proliferation and VEGF expression in human retinal endothelial cells
R GAO, B ZHU, S TANG, J WANG, J REN
Acta Pharmacologica Sinica 2008
Enzastaurin
YB Chen, AS LaCasce
Expert Opinion on Investigational Drugs 2008
Oncologic, Endocrine & Metabolic Emerging drugs in B-cell non-Hodgkin's lymphoma
S Kassam, S Montoto
Expert Opinion on Emerging Drugs 2008
Trans-Resveratrol Inhibits Early Blood Vessel Formation (Vasculogenesis) Without Impairment of Embryonic Growth
PF Dias, FV Berti, JM Siqueira, M Maraschin, AR Gagliardi, RM Ribeiro-do-Valle
Journal of Pharmacological Sciences 2008
The Role of Inflammatory Cytokines in Diabetes and Its Complications
GL King
Journal of Periodontology 2008
Emerging drugs for diabetic retinopathy
Q Mohamed, TY Wong
Expert Opinion on Emerging Drugs 2008
Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase
IM Evans, G Britton, IC Zachary
Cellular Signalling 2008
VEGF Attenuates Hyperoxic Injury through Decreased Apoptosis in Explanted Rat Embryonic Lung
AE Esquibies, A Bazzy-Asaad, F Ghassemi, H Nishio, A Karihaloo, LG Cantley
Pediatric Research 2008
Phosphoinositide 3-kinase signalling in the vascular system
F Morello, A Perino, E Hirsch
Cardiovascular Research 2008
Vascular endothelial growth factor-dependent and -independent regulation of angiogenesis
M Shibuya
BMB Reports 2008
Microcirculation
K Ley
Microcirculation 2008
Enzastaurin, an inhibitor of PKCβ, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells
AC Spalding, BD Zeitlin, K Wilder-Romans, ME Davis, JE Nor, TS Lawrence, E Ben-Josef
Translational oncology 2008
Hepatocyte Growth Factor Inhibits VEGF-Forkhead–Dependent Gene Expression in Endothelial Cells
R Abid, RJ Nadeau, KC Spokes, T Minami, D Li, SC Shih, WC Aird
Arteriosclerosis, thrombosis, and vascular biology 2008
Antiangiogenic Agents in Cancer Therapy
BA Teicher, LM Ellis
2008
Vascular endothelial growth factor regulates Stanniocalcin-1 expression via Neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth Factor-2
DI Holmes, IC Zachary
Cellular Signalling 2008
Retinal and Choroidal Angiogenesis
JS Penn
2008
Protective role of intracellular zinc in myocardial ischemia/reperfusion is associated with preservation of protein kinase C isoforms
G Karagulova, Y Yue, A Moreyra, M Boutjdir, I Korichneva
The Journal of pharmacology and experimental therapeutics 2007
Oxidative Stress and Diabetic Retinopathy
RA Kowluru, PS Chan
Experimental Diabetes Research 2007
Cellular Signaling and Potential New Treatment Targets in Diabetic Retinopathy
ZA Khan, S Chakrabarti
Experimental Diabetes Research 2007
The role of protein kinase C activation in diabetic nephropathy
H Noh, GL King
Kidney International 2007
AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production
JA Reihill, MA Ewart, DG Hardie, IP Salt
Biochemical and Biophysical Research Communications 2007
Pharmacologic therapies for diabetic retinopathy and diabetic macular edema
E Rechtman, A Harris, HJ Garzozi, TA Ciulla
Clinical ophthalmology (Auckland, N.Z.) 2007
The therapeutic role of targeting protein kinase C in solid and hematologic malignancies
K Podar, MS Raab, D Chauhan, KC Anderson
Expert Opinion on Investigational Drugs 2007
Correlations of mRNA expression and in vitro chemosensitivity to enzastaurin in freshly explanted human tumor cells
AR Hanauske, U Eismann, O Oberschmidt, H Pospisil, HM Hanauske-Abel, J Blatter, D Ma, V Chen, M Lahn
Investigational New Drugs 2007
Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in vitro soft-agar cloning experiments
AR Hanauske, O Oberschmidt, H Hanauske-Abel, MM Lahn, U Eismann
Investigational New Drugs 2007
Protein kinase C and other diacylglycerol effectors in cancer
EM Griner, MG Kazanietz
Nature Reviews Cancer 2007
Targeting the protein kinase C family: are we there yet?
HJ Mackay, CJ Twelves
Nature Reviews Cancer 2007
Evaluation of VEGF-mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells
CE Clarkin, RJ Emery, AA Pitsillides, CP Wheeler-Jones
Journal of Cellular Physiology 2007
PKC inhibition and diabetic microvascular complications
M Clarke, PM Dodson
Best Practice & Research Clinical Endocrinology & Metabolism 2007
Vascular permeability in ocular disease and the role of tight junctions
KK Erickson, JM Sundstrom, DA Antonetti
Angiogenesis 2007
Protein kinase C inhibition in diabetic retinopathy and microvascular disease
C Walton, RE Ryder, A Girach
Practical Diabetes International 2007
Glycine as a potent anti-angiogenic nutrient for tumor growth
S Yamashina, K Ikejima, I Rusyn, N Sato
Journal of Gastroenterology and Hepatology 2007
Strategies for blocking angiogenesis in diabetic retinopathy: from basic science to clinical practice
C Hernández, R Simó
Expert Opinion on Investigational Drugs 2007
The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis
D Liu, I Evans, G Britton, I Zachary
Oncogene 2007
Effects of Angiotensin II on human endothelial cells survival signalling pathways and its angiogenic response
B Kou, M Vatish, DR Singer
Vascular Pharmacology 2007
Key Signaling Pathways and Targets in Lung Cancer Therapy
NW Choong, R Salgia, EE Vokes
Clinical Lung Cancer 2007
Type 1 Diabetes in Adults: Principles and Practice
J Cropsey, M Fineman
Type 1 Diabetes in Adults: Principles and Practice 2007
Geriatric Diabetes
M Burge, L Gamache, H Pai, A Segal
Geriatric Diabetes 2007
YB-1 is a Transcription/Translation Factor that Orchestrates the Oncogenome by Hardwiring Signal Transduction to Gene Expression
J Wu, AL Stratford, A Astanehe, SE Dunn
Translational oncogenomics 2007
Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition
K Holmes, OL Roberts, AM Thomas, MJ Cross
Cellular Signalling 2007
NADPH Oxidase Activity Selectively Modulates Vascular Endothelial Growth Factor Signaling Pathways
MR Abid, KC Spokes, SC Shih, WC Aird
The Journal of biological chemistry 2007
Effects on protein kinase C-β inhibition on glomerular vascular endothelial growth factor expression and endothelial cells in advanced experimental diabetic nephropathy
DJ Kelly, D Buck, AJ Cox, Y Zhang, RE Gilbert
American journal of physiology. Renal physiology 2007
Retrospective analysis of protein kinase C-beta (PKC-β) expression in lymphoid malignancies and its association with survival in diffuse large B-cell lymphomas
S Li, M Phong, M Lahn, L Brail, S Sutton, BK Lin, D Thornton, B Liao
Biology direct 2007
Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance
K Naruse, C Rask-Madsen, N Takahara, S Ha, K Suzuma, KJ Way, JR Jacobs, AC Clermont, K Ueki, Y Ohshiro, J Zhang, AB Goldfine, GL King
Diabetes 2006
Pathogenic mechanisms of anti-endothelial cell antibodies (AECA): their prevalence and clinical relevance
Cristiano Alessandri, Michele Bombardieri, Guido Valesini
Advances in Clinical Chemistry 2006
Diabetic Cardiomyopathy
GC Fonarow, P Srikanthan
Endocrinology & Metabolism Clinics of North America 2006
The role of VEGF receptors in angiogenesis; complex partnerships
S Cébe-Suarez, A Zehnder-Fjällman, K Ballmer-Hofer
Cellular and Molecular Life Sciences 2006
Chronic treatment with vascular endothelial growth factor preserves agonist-evoked vascular responses in the streptozotocin-induced diabetic rat
S Bardal, D Misurski, X Qiu, K Desai, JR McNeill
Diabetologia 2006
Src, Fyn and Yes play differential roles in VEGF-mediated endothelial cell events
XQ Werdich, JS Penn
Angiogenesis 2006
Small molecular weight G-protein, H-Ras, and retinal endothelial cell apoptosis in diabetes
RA Kowluru, A Kowluru, M Kanwar
Molecular and Cellular Biochemistry 2006
Zinc Dynamics in the Myocardial Redox Signaling Network
I Korichneva
Antioxidants & Redox Signaling 2006
Protein kinase C (PKC) family in cancer progression
J Koivunen, V Aaltonen, J Peltonen
Cancer Letters 2006
Regulators of angiogenesis and strategies for their therapeutic manipulation
M Milkiewicz, E Ispanovic, JL Doyle, TL Haas
The International Journal of Biochemistry & Cell Biology 2006
Emerging drugs for age-related macular degeneration
AJ Augustin, I Offermann
Expert Opinion on Emerging Drugs 2006
Vascular endothelial growth factor increases the intracellular magnesium
BZ Hong, HS Kang, JN So, HN Kim, SA Park, SJ Kim, KR Kim, YG Kwak
Biochemical and Biophysical Research Communications 2006
Differential Roles of Vascular Endothelial Growth Factor Receptor-1 and Receptor-2 in Angiogenesis
M Shibuya
Journal of Biochemistry and molecular biology 2006
Vascular Endothelial Growth Factor (VEGF)-Receptor2: Its Biological Functions, Major Signaling Pathway, and Specific Ligand VEGF-E
M Shibuya
Endothelium : journal of endothelial cell research 2006
A Novel Class of Vascular Endothelial Growth Factor-responsive Genes That Require Forkhead Activity for Expression
MR Abid, SC Shih, HH Otu, KC Spokes, Y Okada, DT Curiel, T Minami, WC Aird
The Journal of biological chemistry 2006
Angiogenic activity of human chorionic gonadotropin through LH receptor activation on endothelial and epithelial cells of the endometrium
S Berndt, SP dHauterive, S Blacher, C Péqueux, S Lorquet, C Munaut, M Applanat, MA Hervé, N Lamandé, P Corvol, F van den Brûle, F Frankenne, M Poutanen, I Huhtaniemi, V Geenen, A Noël, JM Foidart
The FASEB Journal 2006
Phase I Dose Escalation and Pharmacokinetic Study of Enzastaurin, an Oral Protein Kinase C Beta Inhibitor, in Patients With Advanced Cancer
MA Carducci, L Musib, MS Kies, R Pili, M Truong, JR Brahmer, P Cole, R Sullivan, J Riddle, J Schmidt, N Enas, V Sinha, DE Thornton, RS Herbst
Journal of Clinical Oncology 2006
EGF stimulates proliferation of mouse embryonic stem cells: involvement of Ca 2+ influx and p44/42 MAPKs
JS Heo, YJ Lee, HJ Han
American journal of physiology. Cell physiology 2006
Protein kinase C β inhibition: a novel therapeutic strategy for diabetic microangiopathy
I Idris, R Donnelly
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2006
Ocular Angiogenesis
J Tombrain-Tink, CJ Barnstable
2006
Cancer Drug Resistance
BA Teicher
2006
Nutrition and Disease Prevention
K Imaizumi
Soy in Health and Disease Prevention 2005
Glycine as a Therapeutic Immuno-Nutrient for Alcoholic Liver Disease
S Yamashina, K Ikejima, N Enomoto, Y Takei, N Sato
Alcoholism: Clinical & Experimental Research 2005
Staurosporine Promotes Endothelial Cell Assembly and FAK Phosphorylation During In Vitro Angiogenesis
ST Tarzami, SS Hsieh, MA Esterman, JP Singh
Journal of Cardiovascular Pharmacology 2005
Vascular Endothelial Growth Factor Levels in Vitreous and Serum of Patients with either Proliferative Diabetic Retinopathy or Proliferative Vitreoretinopathy
M Sydorova, MS Lee
Ophthalmic Research 2005
Targeting angiogenesis: structural characterization and biological properties of a de novo engineered VEGF mimicking peptide
LD D'Andrea, G Iaccarino, R Fattorusso, D Sorriento, C Carannante, D Capasso, B Trimarco, C Pedone
Proceedings of the National Academy of Sciences 2005
Redox regulation of cardiac protein kinase C
I Korichneva
Experimental and clinical cardiology 2005
Novel concepts of human chorionic gonadotropin: reproductive system interactions and potential in the management of infertility
M Filicori, AT Fazleabas, I Huhtaniemi, P Licht, CV Rao, J Tesarik, M Zygmunt
Fertility and Sterility 2005
Dysfunction of retinal neurons and glia during diabetes
EL Fletcher, JA Phipps, JL Wilkinson-Berka
Clinical and Experimental Optometry 2005
Current and future pharmacological intervention for diabetic retinopathy
GM Comer, TA Ciulla
Expert Opinion on Emerging Drugs 2005
Gene regulation of a novel angiogenesis inhibitor, vasohibin, in endothelial cells
K Shimizu, K Watanabe, H Yamashita, M Abe, H Yoshimatsu, H Ohta, H Sonoda, Y Sato
Biochemical and Biophysical Research Communications 2005
Vascular endothelial growth factor expression and secretion by retinal pigment epithelial cells in high glucose and hypoxia is protein kinase C-dependent
TA Young, H Wang, S Munk, DS Hammoudi, DS Young, MS Mandelcorn, CI Whiteside
Experimental Eye Research 2005
Induction of VE-cadherin in rat placental trophoblasts by VEGF through a NO-dependent pathway
CC Chang, TY Chang, CH Yu, ML Tsai
Placenta 2005
Interleukin 7 upregulates vascular endothelial growth factor D in breast cancer cells and induces lymphangiogenesisin vivo
MA Al-Rawi, G Watkins, RE Mansel, WG Jiang
British Journal of Surgery 2005
Synthesis and isozyme selectivity of small molecule protein kinase C inhibitors: a review of patents
J Sridhar, N Pattabiraman
Expert Opinion on Therapeutic Patents 2005
Vascular endothelial growth factor counteracts NMDA-induced cell death of adult cholinergic neurons in rat basal nucleus of Meynert
KV Moser, C Humpel
Brain Research Bulletin 2005
International Review of Neurobiology
ZT Bloomgarden
International review of neurobiology 2005
The evolution of cancer research and drug discovery at Lilly Research Laboratories
HL Pearce, MA Miller
Advances in Enzyme Regulation 2005
Protein Kinase C-dependent Protein Kinase D Activation Modulates ERK Signal Pathway and Endothelial Cell Proliferation by Vascular Endothelial Growth Factor
C Wong, ZG Jin
The Journal of biological chemistry 2005
Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells
Kota V Ramana, Brian Friedrich, Ravinder Tammali, Matthew B West, Aruni Bhatnagar, Satish K Srivastava
Diabetes 2005
Ruboxistaurin, a Protein Kinase C β Inhibitor, as an Emerging Treatment for Diabetes Microvascular Complications
SV Joy, AC Scates, S Bearelly, M Dar, CA Taulien, JA Goebel, MJ Cooney
The Annals of pharmacotherapy 2005
Lysophosphatidylcholine increases endothelial permeability: role of PKCα and RhoA cross talk
F Huang, PV Subbaiah, O Holian, J Zhang, A Johnson, N Gertzberg, H Lum
American journal of physiology. Lung cellular and molecular physiology 2005
Mechanisms of Angiogenesis
M Clauss, G Breier
2005
Cancer Chemoprevention
GJ Kelloff, ET Hawk, CC Sigman
2005
The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications
K Podar, KC Anderson
Blood 2005
Microvascular complications of diabetes
Z He, GL King
Endocrinology & Metabolism Clinics of North America 2004
From Hyperglycemia to Diabetic Kidney Disease: The Role of Metabolic, Hemodynamic, Intracellular Factors and Growth Factors/Cytokines
BF Schrijvers, AS Vriese, A Flyvbjerg
Endocrine reviews 2004
Hyperglycemia-induced oxidative stress in diabetic complications
GL King, MR Loeken
Histochemistry and Cell Biology 2004
The receptor tyrosine kinase MerTK activates phospholipase C gamma2 during recognition of apoptotic thymocytes by murine macrophages
JC Todt, B Hu, JL Curtis
Journal of leukocyte biology 2004
Protein kinase C inhibition and diabetic retinopathy: a shot in the dark at translational research
R Donnelly, I Idris, JV Forrester
The British journal of ophthalmology 2004
Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization
D Watanabe, H Takagi, K Suzuma, I Suzuma, H Oh, H Ohashi, S Kemmochi, A Uemura, T Ojima, E Suganami, N Miyamoto, Y Sato, Y Honda
The American Journal of Pathology 2004
Pharmacotherapy for diabetic retinopathy
GM Comer, TA Ciulla
Current Opinion in Ophthalmology 2004
Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms
E Sulpice, JO Contreres, J Lacour, M Bryckaert, G Tobelem
European Journal of Biochemistry 2004
Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells
K Shimamura, Y Takashiro, N Akiyama, T Hirabayashi, T Murayama
European Journal of Pharmacology 2004
Vascular endothelial growth factor in diabetes induced early retinal abnormalities
M Cukiernik, D Hileeto, T Evans, S Mukherjee, D Downey, S Chakrabarti
Diabetes Research and Clinical Practice 2004
Tumor Necrosis Factor-  in Diabetic Plasma Increases the Activity of Core 2 GlcNAc-T and Adherence of Human Leukocytes to Retinal Endothelial Cells: Significance of Core 2 GlcNAc-T in Diabetic Retinopathy
BM Ben-Mahmud, GE Mann, A Datti, A Orlacchio, EM Kohner, R Chibber
Diabetes 2004
Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-alpha-dependent pathway
Vicki Thallas-Bonke, Carsten Lindschau, Bishoy Rizkalla, Leon A Bach, Geoffrey Boner, Matthias Meier, Hermann Haller, Mark E Cooper, Josephine M Forbes
Diabetes 2004
Blood-retinal barrier breakdown induced by activation of protein kinase C via vascular endothelial growth factor in streptozotocin-induced diabetic rats
X Xu, Q Zhu, X Xia, S Zhang, Q Gu, D Luo
Current Eye Research 2004
Vascular endothelial growth factor receptor-1 and receptor-2 initiate a phosphatidylinositide 3-kinase–dependent clonogenic response in acute myeloid leukemia cells
AF List, B Glinsmann-Gibson, C Stadheim, EJ Meuillet, W Bellamy, G Powis
Experimental Hematology 2004
Anti-chemorepulsive Effects of Vascular Endothelial Growth Factor and Placental Growth Factor-2 in Dorsal Root Ganglion Neurons Are Mediated via Neuropilin-1 and Cyclooxygenase-derived Prostanoid Production
L Cheng, H Jia, M Löhr, A Bagherzadeh, DI Holmes, D Selwood, I Zachary
The Journal of biological chemistry 2004
Growth factors and protein kinase C inhibitors as novel therapies for the medical management diabetic retinopathy
LP Aiello, MT Cahill, JD Cavallerano
Eye 2004
The receptor tyrosine kinase MerTK activates phospholipase C γ2 during recognition of apoptotic thymocytes by murine macrophages
JC Todt, B Hu, JL Curtis
Journal of leukocyte biology 2004
Localization of VEGFR-2 and PLD 2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK
CH Cho, CS Lee, M Chang, IH Jang, SJ Kim, I Hwang, SH Ryu, CO Lee, GY Koh
American journal of physiology. Heart and circulatory physiology 2004
Vascular Endothelial Growth Factor (VEGF)-D and VEGF-A Differentially Regulate KDR-mediated Signaling and Biological Function in Vascular Endothelial Cells
H Jia, A Bagherzadeh, R Bicknell, MR Duchen, D Liu, I Zachary
The Journal of biological chemistry 2004
Integrin-linked kinase regulates vascular morphogenesis induced by vascular endothelial growth factor
Y Kaneko, K Kitazato, Y Basaki
Journal of cell science 2004
Nitric oxide signaling during myocardial angiogenesis
T Kondo, K Kobayashi, T Murohara
Molecular and Cellular Biochemistry 2004
The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning
D Escalante-Alcalde, L Hernandez, HL Stunff, R Maeda, HS Lee, G Cheng, VA Sciorra, I Daar, S Spiegel, AJ Morris, CL Stewart
Development (Cambridge, England) 2003
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini
International Textbook of Diabetes Mellitus 2003
Abnormal angiogenesis in diabetes mellitus
A Martin, MR Komada, DC Sane
Medicinal Research Reviews 2003
Oxidants in Receptor Tyrosine Kinase Signal Transduction Pathways
M Aslan, T Özben
Antioxidants & Redox Signaling 2003
VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors
J Igarashi, PA Erwin, AP Dantas, H Chen, T Michel
Proceedings of the National Academy of Sciences 2003
VEGF-receptor inhibitors for anti-angiogenesis
M SHIBUYA
Folia Pharmacologica Japonica 2003
Opposing effect of angiopoietin-1 on VEGF-mediated disruption of endothelial cell-cell interactions requires activation of PKC?
Y Wang, S Pampou, K Fujikawa, L Varticovski
Journal of Cellular Physiology 2003
Vascular endothelial growth factor receptor-2: Its unique signaling and specific ligand, VEGF-E
M Shibuya
Cancer Science 2003
Mechanisms Underlying the Programming of Small Artery Dysfunction: Review of the Model Using Low Protein Diet in Pregnancy in the Rat
L Brawley, L Poston, MA Hanson
Archives Of Physiology And Biochemistry 2003
Modulation of VE-cadherin and PECAM-1 mediated cell-cell adhesions by mitogen-activated protein kinases
J Wu, N Sheibani
Journal of Cellular Biochemistry 2003
Strategies for the synthesis of N-(azacycloalkyl)bisindolylmaleimides: selective inhibitors of PKCβ
MM Faul, JL Grutsch, ME Kobierski, ME Kopach, CA Krumrich, MA Staszak, U Udodong, JT Vicenzi, KA Sullivan
Tetrahedron 2003
Management of Diabetic Nephropathy
B Schrijvers, AD Vriese, A Flyvbjerg
Management of Diabetic Nephropathy 2003
Diabetic macular edema: classification, medical and laser therapy
FB MD, R Pognuz, AP MD, AP MD, FM MD, MA MD
Seminars in Ophthalmology 2003
Diabetic retinopathy and diabetic macular edema: pathophysiology, screening, and novel therapies
Thomas A Ciulla, Armando G Amador, Bernard Zinman
Diabetes care 2003
Effects of protein kinase C inhibition and activation on proliferation and apoptosis of bovine retinal pericytes
F Pomero, A Allione, E Beltramo, S Buttiglieri, F D'Alù, E Ponte, A Lacaria, M Porta
Diabetologia 2003
Biochemical Pathways for Microvascular Complications of Diabetes Mellitus
SM Setter, RK Campbell, CJ Cahoon
The Annals of pharmacotherapy 2003
O papel da proteína quinase C no desenvolvimento das complicações vasculares do diabetes mellitus
BD Schaan
Arquivos brasileiros de endocrinologia e metabologia 2003
Medical treatment of diabetic retinopathy
M Donaldson, PM Dodson
Eye 2003
Negative regulatory role of PI3-Kinase in TNF-induced tumor necrosis
S Matschurat, S Blum, R Mitnacht-Kraus, HB Dijkman, L Kanal, RM de Waal, M Clauss
International Journal of Cancer 2003
Additive effects of hypertension and diabetes on renal cortical expression of PKC-?? and -??? and ??-tubulin but not PKC-??1 and -??2:
TM Osicka, LM Russo, ML Qiu, GC Brammar, V Thallas, JM Forbes, WD Comper, G Jerums
Journal of Hypertension 2003
Regulation of Vascular Endothelial Growth Factor Receptor-2 Activity by Caveolin-1 and Plasma Membrane Cholesterol
L Labrecque, I Royal, DS Surprenant, C Patterson, D Gingras, R Béliveau, CH Heldin
Molecular biology of the cell 2003
Small GTP-Binding Protein Rac Is an Essential Mediator of Vascular Endothelial Growth Factor-Induced Endothelial Fenestrations and Vascular Permeability
A Eriksson, R Cao, J Roy, K Tritsaris, C Wahlestedt, S Dissing, J Thyberg, Y Cao
Circulation 2003
Vascular endothelial growth factor receptor‐2: Its unique signaling and specific ligand, VEGF‐E
Shibuya M
Cancer Science 2003
Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue
E Chou, I Suzuma, KJ Way, D Opland, AC Clermont, K Naruse, K Suzuma, NL Bowling, CJ Vlahos, LP Aiello, GL King
Circulation 2002
Regulation of microvascular permeability by vascular endothelial growth factors
DO Bates, NJ Hillman, B Williams, CR Neal, TM Pocock
Journal of Anatomy 2002
Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: Role of PI3K, PKC and PLC pathways
DS Gélinas, PN Bernatchez, S Rollin, NG Bazan, MG Sirois
British Journal of Pharmacology 2002
Haemodynamics in microvascular complications in type 1 diabetes
R Candido, TJ Allen
Diabetes/Metabolism Research and Reviews 2002
Nitric Oxide and Angiogenesis in Cardiovascular Disease
T Murohara, T Asahara
Antioxidants & Redox Signaling 2002
Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization
K Suzuma, N Takahara, I Suzuma, K Isshiki, K Ueki, M Leitges, LP Aiello, GL King
Proceedings of the National Academy of Sciences 2002
Induction of KDR expression in bovine arterial endothelial cells by thrombin: Involvement of nitric oxide
J Wang, I Morita, M Onodera, S Murota
Journal of Cellular Physiology 2002
Vascular Endothelial Growth Factor Enhances Endothelial Cell Survival and Tumor Radioresistance
VK Gupta, NT Jaskowiak, MA Beckett, HJ Mauceri, J Grunstein, RS Johnson, DA Calvin, E Nodzenski, M Pejovic, DW Kufe, MC Posner, RR Weichselbaum
The Cancer Journal 2002
Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors
RN Frank
American Journal of Ophthalmology 2002
Insulin-like growth factor-1 effects on bovine retinal endothelial cell glucose transport: role of MAP kinase
BJ DeBosch, BK Deo, AK Kumagai
Journal of Neurochemistry 2002
The Potential Role of PKC β in Diabetic Retinopathy and Macular Edema
LP Aiello
Survey of Ophthalmology 2002
Changing Times for the Management of Diabetic Retinopathy
DS Fong
Survey of Ophthalmology 2002
Targets for pharmacological intervention of endothelial hyperpermeability and barrier function
GP van Amerongen, VW van Hinsbergh
Vascular Pharmacology 2002
Regulation of vascular permeability by vascular endothelial growth factors
DO Bates, SJ Harper
Vascular Pharmacology 2002
Vasodilation to Vascular Endothelial Growth Factor in the Uterine Artery of the Pregnant Rat Is Blunted by Low Dietary Protein Intake
S Itoh, L Brawley, T Wheeler, FW Anthony, L Poston, MA Hanson
Pediatric Research 2002
Mechanisms of Amelioration of Glucose-Induced Endothelial Dysfunction Following Inhibition of Protein Kinase C In Vivo
G Booth, TJ Stalker, AM Lefer, R Scalia
Diabetes 2002
The Epidemiology of Complications
ZT Bloomgarden
Diabetes care 2002
Diabetic vascular dysfunction: Links to glucose-induced reductive stress and VEGF
RG Tilton
Microscopy Research and Technique 2002
bFGF and VEGF synergistically enhance endothelial cytoprotection via decay-accelerating factor induction
JC Mason, EA Lidington, SR Ahmad, DO Haskard
American journal of physiology. Cell physiology 2002
Enhancement of L-type Ca 2+ current from neonatal mouse ventricular myocytes by constitutively active PKC-βII
KJ Alden, PH Goldspink, SW Ruch, PM Buttrick, J Garcı́a
American journal of physiology. Cell physiology 2002
High glucose abolishes the antiproliferative effect of 17β-estradiol in human vascular smooth muscle cells
S Ling, PJ Little, MR Williams, A Dai, K Hashimura, JP Liu, PA Komesaroff, K Sudhir
American journal of physiology. Endocrinology and metabolism 2002
Angiogenic Oligosaccharides of Hyaluronan Induce Multiple Signaling Pathways Affecting Vascular Endothelial Cell Mitogenic and Wound Healing Responses
M Slevin, S Kumar, J Gaffney
The Journal of biological chemistry 2002
Vascular Dysfunction in Hyperglycemia: Is Protein Kinase C the Culprit?
DD Gutterman
Circulation research 2002
The New Angiotherapy
TP Fan, EC Kohn
2002
Diabetic Renal-Retinal Syndrome
EA Friedman, FA LEsperance
2002
Antiangiogenic and antitumor effects of a protein kinase Cbeta inhibitor in human breast cancer and ovarian cancer xenografts
Beverly A Teicher, Krishna Menon, Enrique Alvarez, Chuan Shih, Margaret M Faul
Investigational New Drugs 2002
Can VEGF reverse diabetic neuropathy in human subjects?
Aristidis Veves, George King
Journal of Clinical Investigation 2001
Handbook of Antioxidants
K Meissner, W Siems, O Sommerburg, M Leichsenring
Handbook of Antioxidants 2001
Protein kinase C and the development of diabetic vascular complications
KJ Way, N Katai, GL King
Diabetic Medicine 2001
Regulation of VEGF-induced endothelial cell PAF synthesis: role of p42/44 MAPK, p38 MAPK and PI3K pathways
PN Bernatchez, BG Allen, DS Gélinas, G Guillemette, MG Sirois
British Journal of Pharmacology 2001
Vascular endothelial growth factor and thein vivoincrease in plasma extravasation in the hamster cheek pouch
M Félétou, J Staczek, J Duhault
British Journal of Pharmacology 2001
Protein kinase C inhibitors in the treatment and prevention of diabetic complications
A Gabriele, GL King
Current Opinion in Endocrinology & Diabetes 2001
The role of oxidative stress in the onset and progression of diabetes and its complications: asummary of a Congress Series sponsored byUNESCO-MCBN, the American Diabetes Association and the German Diabetes Society
P R�sen, PP Nawroth, G King, W M�ller, HJ Tritschler, L Packer
Diabetes/Metabolism Research and Reviews 2001
Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis
H Oh, H Takagi, A Otani, S Koyama, S Kemmochi, A Uemura, Y Honda
Proceedings of the National Academy of Sciences 2001
In vivo mechanisms of vascular endothelial growth factor-mediated increased hydraulic conductivity of Rana capillaries
TM Pocock, DO Bates
The Journal of Physiology 2001
Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells
R Abu-Ghazaleh, J Kabir, H Jia, M Lobo, I Zachary
Biochemical Journal 2001
Vascular endothelial growth factor-induced prostacyclin production is mediated by a protein kinase C (PKC)-dependent activation of extracellular signal-regulated protein kinases 1 and 2 involving PKC-delta and by mobilization of intracellular Ca2+
G Gliki, R Abu-Ghazaleh, S Jezequel, C Wheeler-Jones, I Zachary
Biochemical Journal 2001
Novel approaches to the treatment of progressive renal disease
R Gilbert
Current Opinion in Pharmacology 2001
Kinetics of Placenta Growth Factor/Vascular Endothelial Growth Factor Synergy in Endothelial Hydraulic Conductivity and Proliferation
RO Dull, J Yuan, YS Chang, J Tarbell, RK Jain, LL Munn
Microvascular Research 2001
VEGF Receptor Signal Transduction
T Matsumoto, L Claesson-Welsh
Science signaling 2001
Protein kinase C activity contributes to endothelial hyperpermeability during early angiogenesis in the chick chorioallantoic membrane
LM DeFouw, DO DeFouw
Tissue and Cell 2001
Phosphodiesterase Inhibitor-mediated Potentiation of Adenovirus Delivery to Myocardium
K Nagata, E Marbán, JH Lawrence, KJ Donahue
Journal of Molecular and Cellular Cardiology 2001
Sequential Activation of Protein Kinase C (PKC)-α and PKC-ε Contributes to Sustained Raf/ERK1/2 Activation in Endothelial Cells under Mechanical Strain
JJ Cheng, BS Wung, YJ Chao, DL Wang
The Journal of biological chemistry 2001
Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor
I Zachary
American journal of physiology. Cell physiology 2001
Upregulation of angiotensin-converting enzyme by vascular endothelial growth factor
O Saijonmaa, T Nyman, R Kosonen, F Fyhrquist
American journal of physiology. Heart and circulatory physiology 2001
Regulation of tyrosine phosphorylation of PYK2 in vascular endothelial cells by lysophosphatidylcholine
Y Rikitake, S Kawashima, T Takahashi, T Ueyama, S Ishido, N Inoue, KI Hirata, M Yokoyama
American journal of physiology. Heart and circulatory physiology 2001
Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase
BJ Michell, Z Chen, T Tiganis, D Stapleton, F Katsis, DA Power, AT Sim, BE Kemp
The Journal of biological chemistry 2001
Role of PLCγ and Ca 2+ in VEGF- and FGF-induced choroidal endothelial cell proliferation
AP McLaughlin, GW de Vries
American journal of physiology. Cell physiology 2001
Ischemic Preconditioning Upregulates Vascular Endothelial Growth Factor mRNA Expression and Neovascularization via Nuclear Translocation of Protein Kinase C ε in the Rat Ischemic Myocardium
H Kawata, K Yoshida, A Kawamoto, H Kurioka, E Takase, Y Sasaki, K Hatanaka, M Kobayashi, T Ueyama, T Hashimoto, K Dohi
Circulation research 2001
Purinergic and Pyrimidinergic Signalling I
MP Abbracchio, M Williams
2001
Rational Approaches to Design of Therapeutics Targeting Molecular Markers
RJ Klasa, AF List, BD Cheson
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2001
Increased H2O2, vascular endothelial growth factor and receptors in the retina of the BBZ/WOR diabetic rat
EA Ellis, DL Guberski, M Somogyi-Mann, MB Grant
Free radical biology & medicine 2000
Effect of Vascular Endothelial Growth Factor on Cultured Endothelial Cell Monolayer Transport Properties
YS Chang, LL Munn, MV Hillsley, RO Dull, J Yuan, S Lakshminarayanan, TW Gardner, RK Jain, JM Tarbell
Microvascular Research 2000
Role of vasoactive factors in the pathogenesis of early changes in diabetic retinopathy
S Chakrabarti, M Cukiernik, D Hileeto, T Evans, S Chen
Diabetes/Metabolism Research and Reviews 2000
Vascular Endothelial Growth Factor (VEGF) Enhances the Expression of Receptors and Activates Mitogen-Activated Protein (MAP) Kinase of Dog Retinal Capillary Endothelial Cells
M Murata, P Kador, S Sato
Journal of Ocular Pharmacology and Therapeutics 2000
Role of vascular endothelial growth factor in diabetic vascular complications
LP Aiello, JS Wong
Kidney International 2000
Tyrosine phosphorylation of the vascular endothelial-growth-factor receptor-2 (VEGFR-2) is modulated by Rho proteins
D Gingras, S Lamy, R Béliveau
Biochemical Journal 2000
Vascular endothelial growth factor stimulates dephosphorylation of the catenins p120 and p100 in endothelial cells
EY Wong, L Morgan, C Smales, P Lang, SE Gubby, JM Staddon
Biochemical Journal 2000
Adaptive Responses of the Endothelium to Stress
TH Pohlman, JM Harlan
Journal of Surgical Research 2000
Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis
MJ Karkkainen, TV Petrova
Oncogene 2000
Protein kinase C activation and its pharmacological inhibition in vascular disease
M Meier, GL King
Vascular medicine (London, England) 2000
Vascular Endothelial Growth Factor Induces Expression of Connective Tissue Growth Factor via KDR, Flt1, and Phosphatidylinositol 3-Kinase-Akt-dependent Pathways in Retinal Vascular Cells
K Suzuma, K Naruse, I Suzuma, N Takahara, K Ueki, LP Aiello, GL King
The Journal of biological chemistry 2000
Utilization of Distinct Signaling Pathways by Receptors for Vascular Endothelial Cell Growth Factor and Other Mitogens in the Induction of Endothelial Cell Proliferation
LW Wu, LD Mayo, JD Dunbar, KM Kessler, MR Baerwald, EA Jaffe, D Wang, RS Warren, DB Donner
The Journal of biological chemistry 2000
Homeostatic Modulation of Cell Surface KDR and Flt1 Expression and Expression of the Vascular Endothelial Cell Growth Factor (VEGF) Receptor mRNAs by VEGF
D Wang, DB Donner, RS Warren
The Journal of biological chemistry 2000
Protein kinase C-α mediates endothelial barrier dysfunction induced by TNF-α
T Ferro, P Neumann, N Gertzberg, R Clements, A Johnson
American journal of physiology. Lung cellular and molecular physiology 2000
Vascular Endothelial Growth Factor KDR Receptor Signaling Potentiates Tumor Necrosis Factor-induced Tissue Factor Expression in Endothelial Cells
BQ Shen, DY Lee, KM Cortopassi, LA Damico, TF Zioncheck
The Journal of biological chemistry 2000
Vascular Endothelial Growth Factor Expression of Intercellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule 1 (VCAM-1), and E-selectin through Nuclear Factor-κB Activation in Endothelial Cells
I Kim, SO Moon, SH Kim, HJ Kim, YS Koh, GY Koh
The Journal of biological chemistry 2000
Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes
D Koya, M Haneda, H Nakagawa, K Isshiki, H Sato, S Maeda, T Sugimoto, H Yasuda, A Kashiwagi, DK Ways, GL King, R Kikkawa
The FASEB Journal 2000
Protein Kinase C and Myocardial Biology and Function
K Naruse, GL King
Circulation research 2000
Regulation of Endothelial Constitutive Nitric Oxide Synthase Gene Expression in Endothelial Cells and In Vivo: A Specific Vascular Action of Insulin
K Kuboki, ZY Jiang, N Takahara, SW Ha, M Igarashi, T Yamauchi, EP Feener, TP Herbert, CJ Rhodes, GL King
Circulation 2000
Regulation of cdk2 Activity in Endothelial Cells That Are Inhibited From Growth by Cell Contact
D Chen, K Walsh, J Wang
Arteriosclerosis, thrombosis, and vascular biology 2000
Apoptosis in Cardiac Biology
H Schunkert, GA Riegger
2000
Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells
S Koyama, H Takagi, A Otani, K Suzuma, K Nishimura, Y Honda
British Journal of Pharmacology 1999
Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications?
S Bursell
Diabetes Research and Clinical Practice 1999
Vascular Endothelial Growth Factor and Microvascular Permeability
DO Bates, D Lodwick, B Williams
Microcirculation 1999
Expression of Thrombospondin-1 in Ischemia-Induced Retinal Neovascularization
K Suzuma, H Takagi, A Otani, H Oh, Y Honda
The American Journal of Pathology 1999
Enzymatic rationale and preclinical support for a potent protein kinase Cβ inhibitor in cancer therapy
B Teicher
Advances in Enzyme Regulation 1999
Molecular mechanisms of growth factor action in diabetic retinopathy
LP Aiello, Y Hata
Current Opinion in Endocrinology & Diabetes 1999
Antagonising the expression of VEGF in pathological angiogenesis
PE Brenchley
Expert Opinion on Therapeutic Patents 1998
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells
A Papapetropoulos, G García-Cardeña, JA Madri, WC Sessa
Journal of Clinical Investigation 1997
Growth factor antagonists for the treatment of diabetic vascular complications
RG Tilton, RA Dixon, TA Brock
Expert Opinion on Investigational Drugs 1997
Granulocyte colony-stimulating factor-induced activation of protein kinase-C in myeloid cells
RV Deshpande, RH Peterson, MA Moore
Journal of Cellular Biochemistry 1997
Role of vascular permeability factor/vascular endothelial growth factor in eye disease
RO Schlingemann, VW van Hinsbergh
The British journal of ophthalmology 1997
The Phosphorylated 1169-Tyrosine Containing Region of Flt-1 Kinase (VEGFR-1) Is a Major Binding Site for PLCγ
A Sawano, T Takahashi, S Yamaguchi, M Shibuya
Biochemical and Biophysical Research Communications 1997
Interactions of FLT-1 and KDR with Phospholipase C γ: Identification of the Phosphotyrosine Binding Sites
SA Cunningham, MP Arrate, TA Brock, MN Waxham
Biochemical and Biophysical Research Communications 1997
Surgical and Other Treatments of Diabetic Macular Edema: An Update
JB Christoforidis, DJ D???Amico
International Ophthalmology Clinics
Vascular endothelial growth factor 121 and 165 in the subacromial bursa are involved in shoulder joint contracture in type II diabetics with rotator cuff disease
A Handa, M Gotoh, K Hamada, K Yanagisawa, H Yamazaki, M Nakamura, Y Ueyama, J Mochida, H Fukuda
Journal of Orthopaedic Research 2003
Serotonin-stimulated increase in cytosolic Ca2+ in cultured rat heart endothelial cells
HZ Lee, CH Wu
European Journal of Pharmacology 1999
Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src
H He, VJ Venema, X Gu, RC Venema, MB Marrero, RB Caldwell
The Journal of biological chemistry 1999
Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells
H Oh, H Takagi, K Suzuma, A Otani, M Matsumura, Y Honda
The Journal of biological chemistry 1999
Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner
Y Fujio, K Walsh
The Journal of biological chemistry 1999
Akt Mediates Cytoprotection of Endothelial Cells by Vascular Endothelial Growth Factor in an Anchorage-dependent Manner*
Y Fujio, K Walsh
The Journal of biological chemistry 1999
Signaling via Vascular Endothelial Growth Factor Receptors
TV Petrova, T Makinen, K Alitalo
Experimental Cell Research 1999
Alterations in protein tyrosine kinase pathways following retinal vein occlusion in the rat
A Hayashi, HC Kim, E Juan
Current Eye Research 1999
Vascular Endothelial Growth Factor Governs Endothelial Nitric-oxide Synthase Expression via a KDR/Flk-1 Receptor and a Protein Kinase C Signaling Pathway
BQ Shen, DY Lee, TF Zioncheck
The Journal of biological chemistry 1999
Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability
H Wu, Y Yuan, DC Zawieja, J Tinsley, HJ Granger
American journal of physiology. Heart and circulatory physiology 1999
Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response
EI Korpelainen, M Kärkkäinen, Y Gunji, M Vikkula, K Alitalo
Oncogene 1999
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
T Takahashi, H Ueno, M Shibuya
Oncogene 1999
VEGF stimulates tyrosine phosphorylation of β-catenin and small-pore endothelial barrier dysfunction
AW Cohen, JM Carbajal, RC Schaeffer
American journal of physiology. Heart and circulatory physiology 1999
Growth factor signaling pathways in vascular development
MD Tallquist, P Soriano, RA Klinghoffer
Oncogene 1999
Vascular Endothelial Growth Factor–Induced Endothelial Cell Migration and Proliferation Depend on a Nitric Oxide–Mediated Decrease in Protein Kinase Cδ Activity
Y Shizukuda, S Tang, R Yokota, JA Ware
Circulation research 1999
Soybean Phytochemicals Inhibit the Growth of Transplantable Human Prostate Carcinoma and Tumor Angiogenesis in Mice
JR Zhou, ET Gugger, T Tanaka, Y Guo, GL Blackburn, SK Clinton
The Journal of nutrition 1999
Bradycardia-Induced Coronary Angiogenesis Is Dependent on Vascular Endothelial Growth Factor
W Zheng, MD Brown, TA Brock, RJ Bjercke, RJ Tomanek
Circulation research 1999
The Proliferative Effect of Vascular Endothelial Growth Factor Requires Protein Kinase C-α and Protein Kinase C-ζ
M Wellner, C Maasch, C Kupprion, C Lindschau, FC Luft, H Haller
Arteriosclerosis, thrombosis, and vascular biology 1999
Physiological concentrations of gangliosides gm1, gm2 and gm3 differentially modify basic-fibroblast-growth-factor-induced mitogenesis and the associated signalling pathway in endothelial cells
M Slevin, S Kumar, X He, J Gaffney
International Journal of Cancer 1999
Vascular Growth Factors and Angiogenesis
L Claesson-Welsh
1999
The Role of Protein Kinase C Activation in the Pathogenesis of Diabetic Vascular Complications
JY Park, SW Ha, GL King
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 1999
Induction of Decay-Accelerating Factor by Cytokines or the Membrane-Attack Complex Protects Vascular Endothelial Cells Against Complement Deposition
JC Mason, H Yarwood, K Sugars, BP Morgan, KA Davies, DO Haskard
Blood 1999
Vascular Endothelial Growth Factor Activates Nuclear Factor of Activated T Cells in Human Endothelial Cells: a Role for Tissue Factor Gene Expression
AL Armesilla, E Lorenzo, PG del Arco, S Martínez-Martínez, A Alfranca, JM Redondo
Molecular and cellular biology 1999
Pituitary Expression of Protein Kinase C Isotypes During Early Development
AI Korytko, AP Fields, LA Allshouse, L Cuttler
Journal of Neuroendocrinology 1998
Vascular endothelial growth factor
I Zachary
The International Journal of Biochemistry & Cell Biology 1998
Angiotensin II potentiates vascular endothelial growth factor-induced angiogenic activity in retinal microcapillary endothelial cells
A Otani, H Takagi, K Suzuma, Y Honda
Circulation research 1998
Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro
BQ Shen, DY Lee, HP Gerber, BA Keyt, N Ferrara, TF Zioncheck
The Journal of biological chemistry 1998
Transcription factors Sp1 and Sp3 alter vascular endothelial growth factor receptor expression through a novel recognition sequence
Y Hata, E Duh, K Zhang, GS Robinson, LP Aiello
The Journal of biological chemistry 1998
Induction of angiotensin I-converting enzyme transcription by a protein kinase C-dependent mechanism in human endothelial cells
E Villard, A Alonso, M Agrapart, M Challah, F Soubrier
The Journal of biological chemistry 1998
Vascular Permeability Factor/Vascular Endothelial Cell Growth Factor-mediated Permeability Occurs through Disorganization of Endothelial Junctional Proteins
CG Kevil, DK Payne, E Mire, JS Alexander
The Journal of biological chemistry 1998
VEGF induces hyperpermeability by a direct action on endothelial cells
S Hippenstiel, M Krüll, A Ikemann, W Risau, M Clauss, N Suttorp
American journal of physiology. Lung cellular and molecular physiology 1998
Endocrinology of Cardiovascular Function
ER Levin, JL Nadler
1998
The Biology of Tumors
E Mihich, C Croce
1998
Protein Kinase C Mediates the Mitogenic Action of Thrombopoietin in c-Mpl–Expressing UT-7 Cells
Y Hong, D Dumènil, B van der Loo, F Goncalves, W Vainchenker, JD Erusalimsky
Blood 1998
Tyrosine 1101 of Tie2 Is the Major Site of Association of p85 and Is Required for Activation of Phosphatidylinositol 3-Kinase and Akt
CD Kontos, TP Stauffer, WP Yang, JD York, L Huang, MA Blanar, T Meyer, KG Peters
Molecular and cellular biology 1998
Vascular endothelial growth factor and severity of nonproliferative diabetic retinopathy mediate retinal hemodynamics in vivo: a potential role for vascular endothelial growth factor in the progression of nonproliferative diabetic retinopathy
AC Clermont, LP Aiello, F Mori, LM Aiello, SE Bursell
American Journal of Ophthalmology 1997
Human umbilical vein and dermal microvascular endothelial cells show heterogeneity in response to PKC activation
JC Mason, H Yarwood, K Sugars, DO Haskard
American journal of physiology. Cell physiology 1997
Diabetic Retinopathy
FH Epstein, TJ Merimee
New England Journal of Medicine 1990
Encyclopedic Reference of Vascular Biology & Pathology
A Bikfalvi
1990

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