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Citations to this article

Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase.
D M Stafforini, … , P W Gray, S M Prescott
D M Stafforini, … , P W Gray, S M Prescott
Published June 15, 1996
Citation Information: J Clin Invest. 1996;97(12):2784-2791. https://doi.org/10.1172/JCI118733.
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Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase.

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Abstract

Deficiency of plasma platelet-activating factor (PAF) acetylhydrolase is an autosomal recessive syndrome that has been associated with severe asthma in Japanese children. Acquired deficiency has been described in several human diseases usually associated with severe inflammation. PAF acetylhydrolase catalyzes the degradation of PAF and related phospholipids, which have proinflammatory, allergic, and prothrombotic properties. Thus, a deficiency in the degradation of these lipids should increase the susceptibility to inflammatory and allergic disorders. Miwa et al. reported that PAF acetylhydrolase activity is absent in 4% of the Japanese population, which suggests that it could be a common factor in such disorders, but the molecular basis of the defect is unknown. We show that inherited deficiency of PAF acetylhydrolase is the result of a point mutation in exon 9 and that this mutation completely abolishes enzymatic activity. This mutation is the cause of the lack of enzymatic activity as expression in E. coli of a construct harboring the mutation results in an inactive protein. This mutation as a heterozygous trait is present in 27% in the Japanese population. This finding will allow rapid identification of subjects predisposed to severe asthma and other PAF-mediated disorders.

Authors

D M Stafforini, K Satoh, D L Atkinson, L W Tjoelker, C Eberhardt, H Yoshida, T Imaizumi, S Takamatsu, G A Zimmerman, T M McIntyre, P W Gray, S M Prescott

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SY Lee, KH In
Tuberculosis and Respiratory Diseases 2006
A Single Nucleotide Polymorphism in the Plasma PAF Acetylhydrolase Gene and Risk of Atherosclerosis in Japanese Patients With Peripheral Artery Occlusive Disease
N Unno, T Sakaguchi, T Nakamura, N Yamamoto, J Sugatani, M Miwa, H Konno
Journal of Surgical Research 2006
Phospholipase Action of Platelet-activating Factor Acetylhydrolase, but Not Paraoxonase-1, on Long Fatty Acyl Chain Phospholipid Hydroperoxides
T Kriska, GK Marathe, JC Schmidt, TM McIntyre, AW Girotti
The Journal of biological chemistry 2006
Plasma PAF-acetylhydrolase: An unfulfilled promise?
SA Karabina, E Ninio
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2006
The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2
S Gora, G Lambeau, JG Bollinger, M Gelb, E Ninio, SA Karabina
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2006
The Val279Phe Variant of the Lipoprotein-Associated Phospholipase A2 Gene Is Associated with Catalytic Activities and Cardiovascular Disease in Korean Men
Y Jang, OY Kim, SJ Koh, JS Chae, YG Ko, JY Kim, H Cho, TS Jeong, WS Lee, JM Ordovas, JH Lee
The Journal of clinical endocrinology and metabolism 2006
PLAC™ test for identification of individuals at increased risk for coronary heart disease
RC Hoogeveen, CM Ballantyne
Expert Review of Molecular Diagnostics 2005
Lipoprotein-associated phospholipase A2: a novel marker of cardiovascular risk and potential therapeutic target
C Macphee, GM Benson, Y Shi, A Zalewski
Expert Opinion on Investigational Drugs 2005
Vasospastic Angina and Microvascular Angina are Differentially Influenced by PON1 A632G Polymorphism in the Japanese
J Mashiba, G Koike, H Kamiunten, M Ikeda, K Sunagawa
Circulation Journal 2005
Phospholipid mediators in the vessel wall: involvement in atherosclerosis
E Ninio
Current Opinion in Clinical Nutrition and Metabolic Care 2005
Lipoprotein-associated phospholipase A2 as a biomarker for coronary disease and stroke
MJ Caslake, CJ Packard
Nature Clinical Practice Cardiovascular Medicine 2005
A Polymorphism in Plasma Platelet-activating Factor Acetylhydrolase is Involved in Resistance to Immunoglobulin Treatment in Kawasaki Disease
T Minami, H Suzuki, T Takeuchi, S Uemura, J Sugatani, N Yoshikawa
The Journal of Pediatrics 2005
Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
HC Neto, DM Stafforini, SM Prescott, GA Zimmerman
Memórias do Instituto Oswaldo Cruz 2005
Release of Free F 2 -isoprostanes from Esterified Phospholipids Is Catalyzed by Intracellular and Plasma Platelet-activating Factor Acetylhydrolases
DM Stafforini, JR Sheller, TS Blackwell, A Sapirstein, FE Yull, TM McIntyre, JV Bonventre, SM Prescott, LJ Roberts
The Journal of biological chemistry 2005
Red Blood Cells Highly Express Type I Platelet-Activating Factor-Acetylhydrolase (PAF-AH) Which Consists of the α1/α2 Complex
K Karasawa, M Shirakura, A Harada, N Satoh, K Yokoyama, M Setaka, K Inoue
Journal of Biochemistry 2005
Neutrophil Adherence to Bladder Microvascular Endothelial Cells following Platelet-Activating Factor Acetylhydrolase Inhibition
SM Vinson, A Rickard, JS Ryerse, J McHowat
The Journal of pharmacology and experimental therapeutics 2005
Platelet-activating factor acetylhydrolase: is it good or bad for you?
CH Chen
Current Opinion in Lipidology 2004
Dyslipidemia Associated with Atherosclerotic Disease Systemically Alters Dendritic Cell Mobilization
V Angeli, J Llodrá, JX Rong, K Satoh, S Ishii, T Shimizu, EA Fisher, GJ Randolph
Immunity 2004
Allelic association analysis of phospholipase A2 genes with schizophrenia
R Junqueira, Q Cordeiro, I Meira-Lima, WF Gattaz, H Vallada
Psychiatric Genetics 2004
Association of gene polymorphisms with coronary artery disease in individuals with or without nonfamilial hypercholesterolemia
K Shimokata, Y Yamada, T Kondo, S Ichihara, H Izawa, K Nagata, T Murohara, M Ohno, M Yokota
Atherosclerosis 2004
PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency
K Naoki, K Asano, N Satoh, K Fukunaga, T Oguma, T Shiomi, Y Suzuki, T Nakajima, K Niimi, Y Shiraishi, A Ishizaka, K Yamaguchi
Biochemical and Biophysical Research Communications 2004
Platelet-activating factor acetylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis
M Osoegawa, M Niino, H Ochi, S Kikuchi, H Murai, T Fukazawa, M Minohara, K Tashiro, J Kira
Journal of Neuroimmunology 2004
Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage
C Sumita, M Maeda, Y Fujio, J Kim, J Fujitsu, S Kasayama, I Yamamoto, J Azuma
Biochimica et Biophysica Acta (BBA) - General Subjects 2004
Plasminogen Activator Inhibitor-1 in the Pathogenesis of Asthma
SH Cho, CH Ryu, CK Oh
Experimental biology and medicine (Maywood, N.J.) 2004
Functional impairment of two novel mutations detected in lipoprotein-associated phospholipase A2 (Lp-PLA2) deficiency patients
M Ishihara, T Iwasaki, M Nagano, J Ishii, M Takano, T Kujiraoka, M Tsuji, H Hattori, M Emi
Journal of Human Genetics 2004
Cardiovascular Pharmacogenetics
MR Wilkins
2004
Anti-inflammatory properties of lipid oxidation products
VN Bochkov, N Leitinger
Journal of Molecular Medicine 2003
Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease
MJ Caslake, CJ Packard
Current Opinion in Lipidology 2003
Plasma platelet activating factor-acetylhydrolase (PAF-AH)
K Karasawa, A Harada, N Satoh, K Inoue, M Setaka
Progress in Lipid Research 2003
Association between the Ala379Val variant of the lipoprotein associated phospholipase A2 and risk of myocardial infarction in the north and south of Europe
AM Abuzeid, E Hawe, SE Humphries, PJ Talmud
Atherosclerosis 2003
No evidence for a putative involvement of platelet-activating factor in systemic lupus erythematosus without active nephritis
Y Denizot, E Liozon, L Guglielmi, K Ly, P Soria, V Loustaud, E Vidal, MO Jauberteau
Mediators of Inflammation 2003
Association of plasma PAF acetylhydrolase gene polymorphism with IMT of carotid arteries in Japanese type 2 diabetic patients
I Yamamoto, J Fujitsu, S Nohnen, T Igarashi, T Motomura, M Inaba, S Tsubakimori, J Azuma
Diabetes Research and Clinical Practice 2003
Platelet-Activating Factor, a Pleiotrophic Mediator of Physiological and Pathological Processes
DM Stafforini, TM McIntyre, GA Zimmerman, SM Prescott
Critical Reviews in Clinical Laboratory Sciences 2003
Altered distribution of plasma PAF-AH between HDLs and other lipoproteins in hyperlipidemia and diabetes mellitus
T Kujiraoka, T Iwasaki, M Ishihara, M Ito, M Nagano, A Kawaguchi, S Takahashi, J Ishi, M Tsuji, T Egashira, IP Stepanova, NE Miller, H Hattori
Journal of lipid research 2003
The PON1 M55L gene polymorphism is associated with reduced HDL-associated PAF-AH activity
AI Kakafika, S Xenofontos, V Tsimihodimos, AP Tambaki, ES Lourida, R Kalaitzidis, MA Cariolou, M Elisaf, AD Tselepis
Journal of lipid research 2003
Phospholipase A2 isoforms: a perspective
S Chakraborti
Cellular Signalling 2003
Multiple Myeloma
KC Anderson, JD Shaughnessy, B Barlogie, JL Harousseau, GD Roodman
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2002
Wiley Encyclopedia of Molecular Medicine
WT Morgan
Wiley Encyclopedia of Molecular Medicine 2002
Single nucleotide polymorphism (G994→T) in the plasma platelet-activating factor-acetylhydrolase gene is associated with graft patency of femoropopliteal bypass
N Unno, T Nakamura, H Mitsuoka, T Saito, K Miki, K Ishimaru, J Sugatani, M Miwa, S Nakamura
Surgery 2002
Association of a G994 →T Missense Mutation in the Plasma Platelet-Activating Factor Acetylhydrolase Gene With Risk of Abdominal Aortic Aneurysm in Japanese
N Unno, T Nakamura, H Mitsuoka, T Uchiyama, N Yamamoto, T Saito, J Sugatani, M Miwa, S Nakamura
Annals of Surgery 2002
Genetic Polymorphisms and Oxidative Stress in Heart Failure
FM Alameddine, AM Zafari
Congestive Heart Failure 2002
THEPATHOPHYSIOLOGY OFASTHMA
L Maddox, DA Schwartz
Annual Review of Medicine 2002
Lp-PLA2: an emerging biomarker of coronary heart disease
N Dada, NW Kim, RL Wolfert
Expert Review of Molecular Diagnostics 2002
Association of a G994 -->T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese
N Unno, T Nakamura, H Mitsuoka, T Uchiyama, N Yamamoto, T Saito, J Sugatani, M Miwa, S Nakamura
Annals of Surgery 2002
Phospholipase A2 enzymes
I Kudo, M Murakami
Prostaglandins & Other Lipid Mediators 2002
Platelet-activating factor receptor
S Ishii, T Nagase, T Shimizu
Prostaglandins & Other Lipid Mediators 2002
Lack of evidence for associations between plasma platelet-activating factor acetylhydrolase deficiency and schizophrenia
T Ohtsuki, H Watanabe, M Toru, T Arinami
Psychiatry Research 2002
Airway hyperresponsiveness in transgenic mice overexpressing platelet activating factor receptor is mediated by an atropine-sensitive pathway
T Nagase, S Ishii, H Shindou, Y Ouchi, T Shimizu
American journal of respiratory and critical care medicine 2002
Inflammation, bioactive lipids and atherosclerosis: potential roles of a lipoprotein-associated phospholipase A2, platelet activating factor-acetylhydrolase
AD Tselepis, MJ Chapman
Atherosclerosis Supplements 2002
Reduction in the extent of atherosclerosis in apolipoprotein E-deficient mice induced by electroporation-mediated transfer of the human plasma platelet-activating factor acetylhydrolase gene into skeletal muscle
M Hase, M Tanaka, M Yokota, Y Yamada
Prostaglandins & Other Lipid Mediators 2002
The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis
Guy A Zimmerman, Thomas M McIntyre, Stephen M Prescott, Diana M Stafforini
Critical Care Medicine 2002
Platelet-activating Factor Acetylhydrolase, and Not Paraoxonase-1, Is the Oxidized Phospholipid Hydrolase of High Density Lipoprotein Particles
GK Marathe, GA Zimmerman, TM McIntyre
The Journal of biological chemistry 2002
Sol Sherry Lecture in Thrombosis: Molecular Events in Acute Inflammation
SM Prescott, TM McIntyre, GA Zimmerman, DM Stafforini
Arteriosclerosis, thrombosis, and vascular biology 2002
The Hereditary Basis of Allergic Diseases
ST Holgate, JW Holloway
2002
Platelet-Activating Factor Activates Two Distinct Effector Pathways in Human Eosinophils
M Kato, H Kimura, Y Motegi, A Tachibana, H Minakami, A Morikawa, H Kita
Journal of immunology (Baltimore, Md. : 1950) 2002
Importance of Mast Cells in the Pathophysiology of Asthma
SH Cho, AJ Anderson, CK Oh
Clinical Reviews in Allergy & Immunology 2002
Intraleucocyte platelet-activating factor levels in desmopressin-treated patients with haemophilia A and von Willebrand disease
K Kavakli, A Huseyinov, I Coker, Y Aydinok, G Nisli
Haemophilia 2001
PAF acetylhydrolase gene polymorphisms and asthma severity
DM Stafforini
Pharmacogenomics 2001
Is there a role of platelet-activating factor in human lung cancer?
Y Denizot, V Desplat, M Drouet, F Bertin, B Melloni
Lung Cancer 2001
Evidence for the Existence of the PAF Acetylhydrolase Mutation (Val279Phe) in Non-Japanese Populations: A Preliminary Study in Turkey, Azerbaijan, and Kyrgyzstan
G Balta, A Gurgey, DK Kudayarov, B Tunc, C Altay
Thrombosis Research 2001
Events at the vascular wall: the molecular basis of inflammation
S M Prescott, T M McIntyre, G A Zimmerman
Journal of Investigative Medicine 2001
Single Nucleotide Polymorphism of Human Platelet-activating Factor Receptor Impairs G-protein Activation
K Fukunaga, S Ishii, K Asano, T Yokomizo, T Shiomi, T Shimizu, K Yamaguchi
The Journal of biological chemistry 2001
Adenovirus-Mediated Gene Transfer of Human Platelet-Activating Factor–Acetylhydrolase Prevents Injury-Induced Neointima Formation and Reduces Spontaneous Atherosclerosis in Apolipoprotein E–Deficient Mice
R Quarck, BD Geest, D Stengel, A Mertens, M Lox, G Theilmeier, C Michiels, M Raes, H Bult, D Collen, PV Veldhoven, E Ninio, P Holvoet
Circulation 2001
Inflammatory Mediators of Cerebral Endothelium: A Role in Ischemic Brain Inflammation
D Stanimirovic, K Satoh
Brain Pathology 2000
PLATELET-ACTIVATINGFACTOR ANDRELATEDLIPIDMEDIATORS
SM Prescott, GA Zimmerman, DM Stafforini, TM McIntyre
Annual Review of Biochemistry 2000
Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice
S Ishii, T Shimizu
Progress in Lipid Research 2000
The Ile198Thr and Ala379Val Variants of Plasmatic Paf-Acetylhydrolase Impair Catalytical Activities and Are Associated with Atopy and Asthma
S Kruse, XQ Mao, A Heinzmann, S Blattmann, MH Roberts, S Braun, PS Gao, J Forster, J Kuehr, JM Hopkin, T Shirakawa, KA Deichmann
The American Journal of Human Genetics 2000
Mast-cell responses in the development of asthma
CO Bingham, KF Austen
Journal of Allergy and Clinical Immunology 2000
Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population
Y Yamada, H Yoshida, S Ichihara, T Imaizumi, K Satoh, M Yokota
Atherosclerosis 2000
Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model
WR Henderson, J Lu, KM Poole, GN Dietsch, EY Chi
Journal of immunology (Baltimore, Md. : 1950) 2000
Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli O157–associated hemolytic uremic syndrome
H Xu, K Iijima, T Shirakawa, S Shiozawa, M Miwa, K Yamaoka, N Kawamura, H Nakamura, N Yoshikawa
American Journal of Kidney Diseases 2000
Plasma platelet-activating factor acetylhydrolase deficiency is associated with atherosclerotic occlusive disease in Japan
N Unno, T Nakamura, H Kaneko, T Uchiyama, N Yamamoto, J Sugatani, M Miwa, S Nakamura
Journal of Vascular Surgery 2000
PAF, a Putative Mediator of Oral Inflammation
LM McManus, RN Pinckard
Critical Reviews in Oral Biology & Medicine 2000
Platelet-activating factor acetylhydrolases in health and disease
LW Tjoelker, DM Stafforini
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2000
Mapping oligogenes for atopy and asthma by meta-analysis
A Collins, S Ennis, W Tapper, NE Morton
Genetics and molecular biology 2000
Platelet-Activating Factor Antagonists: Current Status in Asthma
FP Gomez, R Rodriguez-Roisin
BioDrugs 2000
Oxidative Stress and Vascular Disease
JF Keaney
2000
Deregulated platelet‐activating factor levels and acetylhydrolase activity in patients with idiopathic IgA nephropathy
Y Denizot, C Aupetit, F Bridoux, JC Alphonse, M Cogné, JC Aldigier
Nephrology Dialysis Transplantation 2000
Lipid Activation of CTP:Phosphocholine Cytidylyltransferase α: Characterization and Identification of a Second Activation Domain
A Lykidis, P Jackson, S Jackowski
Biochemistry 2000
Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma
DM Stafforini, T Numao, A Tsodikov, D Vaitkus, T Fukuda, N Watanabe, N Fueki, TM McIntyre, GA Zimmerman, S Makino, SM Prescott
Journal of Clinical Investigation 1999
The genetic basis of atopic asthma
Holloway, Beghe, Holgate
Clinical & Experimental Allergy 1999
Cellular Source(s) of Platelet-Activating-Factor Acetylhydrolase Activity in Plasma
K Asano, S Okamoto, K Fukunaga, T Shiomi, T Mori, M Iwata, Y Ikeda, K Yamaguchi
Biochemical and Biophysical Research Communications 1999
Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy
R Tanaka, K Iijima, H Xu, Y Inoue, R Murakami, T Shirakawa, K Nishiyama, M Miwa, S Shiozawa, H Nakamura, N Yoshikawa
American Journal of Kidney Diseases 1999
Plasma Platelet-activating Factor Acetylhydrolase Deficiency in Japanese Patients with Asthma
N Satoh, K Asano, K Naoki, K Fukunaga, M Iwata, M Kanazawa, K Yamaguchi
American journal of respiratory and critical care medicine 1999
All ApoB-Containing Lipoproteins Induce Monocyte Chemotaxis and Adhesion When Minimally Modified: Modulation of Lipoprotein Bioactivity by Platelet-Activating Factor Acetylhydrolase
C Lee, F Sigari, T Segrado, S Hörkkö, S Hama, PV Subbaiah, M Miwa, M Navab, JL Witztum, PD Reaven
Arteriosclerosis, thrombosis, and vascular biology 1999
Asthma
NB Pride
Asthma 1998
Roles of Plasma Platelet-Activating Factor Acetylhydrolase in Allergic, Inflammatory, and Atherosclerotic Diseases
Y Yamada, M Yokota
Japanese Circulation Journal 1998
Platelet-activating factor acetylhydrolase gene mutation in Japanese nephrotic children
H Xu, K Iijima, SS Tanaka, Y Inoue, T Shirakawa, K Nishiyama, M Miwa, H Nakamura, N Yoshikawa
Kidney International 1998
High density associated enzymes: their role in vascular biology
M Navab, SY Hama, GP Hough, CC Hedrick, R Sorenson, BN la Du, JA Kobashigawa, GC Fonarow, JA Berliner, H Laks, AM Fogelman
Current Opinion in Lipidology 1998
Cloning and Characterization of cDNAs and the Gene Encoding the Mouse Platelet-Activating Factor Acetylhydrolase Ib α Subunit/Lissencephaly-1 Protein
M Péterfy, T Gyuris, D Grosshans, CC Cuaresma, L Takács
Genomics 1998
Phenotypic heterogeneity in asthma and allergy
Sandford, Weir, ParÉ
Clinical & Experimental Allergy 1998
Substrate specificities of neuronal nuclear acetyltransferases involved in the synthesis of platelet-activating factor: Differences in the use of 1-alkyl and 1-acyl lysophospholipid acceptors
R Baker
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1998
Platelet-activating factor acetylhydrolase in seminal plasma: A brief review
S Soubeyrand, P Manjunath
Molecular Reproduction and Development 1998
Role of platelet-activating factor acetylhydrolase gene mutation in childhood immunoglobulin A nephropathy
R Tanaka, K Iijima, R Murakami, H Xu, Y Inoue, T Shirakawa, K Nishiyama, H Nakamura, N Yoshikawa
Nihon Shoni Jinzobyo Gakkai Zasshi 1998
Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 å resolution
Y Wei, L Swenson, C Castro, U Derewenda, W Minor, H Arai, J Aoki, K Inoue, L Servin-Gonzalez, ZS Derewenda
Structure 1998
Identification of the G994 → T missense mutation in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men
Y Yamada, S Ichihara, T Fujimura, M Yokota
Metabolism 1998
Oxatomide inhibits synthesis and release of platelet-activating factor in human neutrophils
K Shindo, M Fukumura
Prostaglandins, Leukotrienes and Essential Fatty Acids 1998
Genetics in childhood atherosclerosis
RA Hegele
Progress in Pediatric Cardiology 1998
Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets
M Suzuki, J Sugatani, M Ino, M Shimura, M Akiyama, R Yamazaki, Y Suzuki, M Miwa
American journal of physiology. Cell physiology 1998
Association of a G 994 →T Missense Mutation in the Plasma Platelet-Activating Factor Acetylhydrolase Gene With Genetic Susceptibility to Nonfamilial Dilated Cardiomyopathy in Japanese
S Ichihara, Y Yamada, M Yokota
Circulation 1998
The genetic basis of atherosclerosis
RA Hegele
International Journal of Clinical & Laboratory Research 1997
Enhancement of leukotriene B4 release in stimulated asthmatic neutrophils by platelet activating factor
K Shindo, K Koide, M Fukumura
Thorax 1997
PAF, a potent proinflammatory mediator, looking for its role in the pathogenesis of joint damage
G Herrero-Beaumont, J Egido
Annals of the rheumatic diseases 1997
Loss of Activity of Plasma Platelet-Activating Factor Acetylhydrolase Due to a Novel Gln281→Arg Mutation
Y Yamada, M Yokota
Biochemical and Biophysical Research Communications 1997
Systematic Screening of the LDL-PLA2Gene for Polymorphic Variants and Case-Control Analysis in Schizophrenia
R Bell, DA Collier, SQ Rice, GW Roberts, CH MacPhee, RW Kerwin, J Price, IS Gloger
Biochemical and Biophysical Research Communications 1997
Airway Responsiveness in Transgenic Mice Overexpressing Platelet-activating Factor Receptor: Roles of Thromboxanes and Leukotrienes
T Nagase, S Ishii, H Katayama, Y Fukuchi, Y Ouchi, T Shimizu
American journal of respiratory and critical care medicine 1997
Genetics of Asthma: A Review
P Manian
Chest 1997
Novel Function of Lecithin-Cholesterol Acyltransferase: HYDROLYSIS OF OXIDIZED POLAR PHOSPHOLIPIDS GENERATED DURING LIPOPROTEIN OXIDATION
J Goyal, K Wang, M Liu, PV Subbaiah
The Journal of biological chemistry 1997
Platelet-activating Factor Acetylhydrolases
DM Stafforini, TM McIntyre, GA Zimmerman, SM Prescott
The Journal of biological chemistry 1997
Alanine Exchanges of Polar Amino Acids in the Transmembrane Domains of a Platelet-activating Factor Receptor Generate Both Constitutively Active and Inactive Mutants
I Ishii, T Izumi, H Tsukamoto, H Umeyama, M Ui, T Shimizu
The Journal of biological chemistry 1997
Activated Mast Cells Release Extracellular Type Platelet-activating Factor Acetylhydrolase That Contributes to Autocrine Inactivation of Platelet-activating Factor
K Nakajima, M Murakami, R Yanoshita, Y Samejima, K Karasawa, M Setaka, S Nojima, I Kudo
The Journal of biological chemistry 1997
Cell-specific Regulation of Expression of Plasma-type Platelet-activating Factor Acetylhydrolase in the Liver
KM Howard, JE Miller, M Miwa, MS Olson
The Journal of biological chemistry 1997
A Mutation in Plasma Platelet-Activating Factor Acetylhydrolase (Val 279 →Phe) is a Genetic Risk Factor for Stroke
M Hiramoto, H Yoshida, T Imaizumi, N Yoshimizu, K Satoh
Stroke; a journal of cerebral circulation 1997
Platelets and Their Factors
F von Bruchhausen, U Walter
1997
Platelet activating factor revisited
KF Chung
Thorax 1997
Determinants of plasma platelet-activating factor acetylhydrolase: heritability and relationship to plasma lipoproteins
R Guerra, B Zhao, V Mooser, D Stafforini, JM Johnston, JC Cohen
Journal of lipid research 1997
Deficiency of plasma platelet-activating factor acetylhydrolase: Roles of blood cells
H Yoshida, K Satoh, M Koyama, M Hiramoto, S Takamatsu
American Journal of Hematology 1996

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