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Citations to this article

Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production.
A Desai-Mehta, … , R Ramsey-Goldman, S K Datta
A Desai-Mehta, … , R Ramsey-Goldman, S K Datta
Published May 1, 1996
Citation Information: J Clin Invest. 1996;97(9):2063-2073. https://doi.org/10.1172/JCI118643.
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Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production.

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Abstract

We investigated the role of the costimulatory molecules, CD40 and its ligand CD40L, in the pathogenesis of human SLE. In comparison to normal subjects or patients in remission, PBMC from active lupus patients had a 21-fold increase in the frequency of CD40L-expressing, CD4+T cells. However, the expression of CD40L induced in either lupus or normal T cells by mitogenic stimulation could be down-regulated equally well by CD40 molecules on autologous B cells. Active lupus patients also had a 22-fold increase in percentage of CD8+ T cells expressing CD40L, consistent with their unusual helper activity in SLE. Surprisingly, patients with active lupus had a 20.5-fold increase in B cells that spontaneously expressed high levels of CD40L, as strongly as their T cells. Although lupus patients in remission had low levels of CD40L+ cells in the range of normal subjects, mitogen-induced upregulation of CD40L expression in the T and B cells was markedly greater than normal, suggesting an intrinsic defect. A mAb to CD40L blocked significantly the ability of lymphocytes from lupus patients with active and established disease to produce the pathogenic variety of antinuclear autoantibodies in vitro, bolstering the possibility of anti-CD40L immunotherapy for lupus. Future studies on the hyperexpression of CD40L could elucidate a regulatory defect in the pathogenic T and B cells of lupus.

Authors

A Desai-Mehta, L Lu, R Ramsey-Goldman, S K Datta

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Clinical and Developmental Immunology 2012
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Seki T, Yuasa S, Fukuda K
Nature Protocols 2012
Amplified B Lymphocyte CD40 Signaling Drives Regulatory B10 Cell Expansion in Mice
JC Poe, SH Smith, KM Haas, K Yanaba, T Tsubata, T Matsushita, TF Tedder
PloS one 2011
Abnormalities of T cell signaling in systemic lupus erythematosus
VR Moulton, GC Tsokos
Arthritis Research & Therapy 2011
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné
Advances in Immunology Volume 110 2011
Tuning of CD40–CD154 Interactions in Human B-Lymphocyte Activation: A Broad Array of In Vitro Models for a Complex In Vivo Situation
S Néron, PJ Nadeau, A Darveau, JF Leblanc
Archivum Immunologiae et Therapiae Experimentalis 2011
Balancing efficacy and toxicity of novel therapies in systemic lupus erythematosus
A Fanouriakis, DT Boumpas, GK Bertsias
Expert Review of Clinical Pharmacology 2011
The role of epigenetic variation in the pathogenesis of systemic lupus erythematosus
T Hughes, AH Sawalha
Arthritis Research & Therapy 2011
Lupus nephritis: current update
R Saxena, T Mahajan, C Mohan
Arthritis Research & Therapy 2011
Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus
FM Strickland, A Hewagama, Q Lu, A Wu, R Hinderer, R Webb, K Johnson, AH Sawalha, C Delaney, R Yung, BC Richardson
Journal of Autoimmunity 2011
Calcium signaling in systemic lupus erythematosus T cells: a treatment target
VC Kyttaris, Z Zhang, O Kampagianni, GC Tsokos
Arthritis & Rheumatism 2011
Generation and clinical application of human T cell-derived induced pluripotent stem cells
T Seki, S Yuasa, K Fukuda
Inflammation and Regeneration 2011
Pathogenesis of Lupus Nephritis
Y Du, C Mohan
Systemic Lupus Erythematosus 2011
Origins of Antinuclear Antibodies
WH Reeves, Y Xu, H Zhuang, Y Li, L Yang
Systemic Lupus Erythematosus 2011
Anti-DNA Antibodies: Structure, Regulation and Pathogenicity
C Aranow, D Zhou, B Diamond
Systemic Lupus Erythematosus 2011
Amplified B Lymphocyte CD40 Signaling Drives Regulatory B10 Cell Expansion in Mice
JC Poe, SH Smith, KM Haas, K Yanaba, T Tsubata, T Matsushita, TF Tedder, WN Khan
PloS one 2011
Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas
A Bolduc, E Long, D Stapler, M Cascalho, T Tsubata, PA Koni, M Shimoda
Journal of immunology (Baltimore, Md. : 1950) 2010
Augmented Antibody Response with Premature Germinal Center Regression in CD40L Transgenic Mice
Y Kishi, Y Aiba, T Higuchi, K Furukawa, T Tokuhisa, T Takemori, T Tsubata
Journal of immunology (Baltimore, Md. : 1950) 2010
Monocyte and Macrophage Abnormalities in Systemic Lupus Erythematosus
Y Li, PY Lee, WH Reeves
Archivum Immunologiae et Therapiae Experimentalis 2010
T cells as therapeutic targets in SLE
JC Crispín, VC Kyttaris, C Terhorst, GC Tsokos
Nature Reviews Rheumatology 2010
Regulatory B cells in autoimmune diseases and mucosal immune homeostasis
X Li, J Braun, B Wei
Autoimmunity 2010
Systems Biology in Drug Discovery and Development
Q Yan
2010
Systems Biology in Drug Discovery and Development
Q Yan
2010
Systems Biology in Drug Discovery and Development
Q Yan
2010
Phenotypic Changes of Lymphocytes in Patients with Systemic Lupus Erythematosus Who Are in Longterm Remission After B Cell Depletion Therapy with Rituximab
S IWATA, K SAITO, M TOKUNAGA, K YAMAOKA, M NAWATA, S YUKAWA, K HANAMI, S FUKUYO, I MIYAGAWA, S KUBO, Y TANAKA
The Journal of rheumatology 2010
Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: Past, present, and future
N Jacob, W Stohl
Autoimmunity 2010
Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritis
J Mehta, A Genin, M Brunner, LV Scalzi, N Mishra, T Beukelman, RQ Cron
Arthritis & Rheumatism 2010
Platelet CD154 Potentiates Interferon-  Secretion by Plasmacytoid Dendritic Cells in Systemic Lupus Erythematosus
P Duffau, J Seneschal, C Nicco, C Richez, E Lazaro, I Douchet, C Bordes, JF Viallard, C Goulvestre, JL Pellegrin, B Weil, JF Moreau, F Batteux, P Blanco
Science Translational Medicine 2010
Monoclonal Antibodies for Systemic Lupus Erythematosus (SLE)
C Ponticelli, G Moroni
Pharmaceuticals (Basel, Switzerland) 2010
Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity
D Yu, CG Vinuesa
Cellular and Molecular Immunology 2010
The role of B cell depleting therapy in graft versus host disease after allogeneic hematopoietic cell transplant
AM Alousi, J Uberti, V Ratanatharathorn
Leukemia & Lymphoma 2010
Treatment of systemic lupus erythematosus with epratuzumab
P Traczewski, L Rudnicka
British Journal of Clinical Pharmacology 2010
Differential B-lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1
JP Graham, KM Arcipowski, GA Bishop
Immunological Reviews 2010
Generation of Induced Pluripotent Stem Cells from Human Terminally Differentiated Circulating T Cells
T Seki, S Yuasa, M Oda, T Egashira, K Yae, D Kusumoto, H Nakata, S Tohyama, H Hashimoto, M Kodaira, Y Okada, H Seimiya, N Fusaki, M Hasegawa, K Fukuda
Cell Stem Cell 2010
Allospecific CD154+ B Cells Associate With Intestine Allograft Rejection in Children
C Ashokkumar, C Bentlejewski, Q Sun, BW Higgs, S Snyder, GV Mazariegos, K Abu-Elmagd, A Zeevi, R Sindhi
Transplantation 2010
Estrogen receptor signaling and its relationship to cytokines in systemic lupus erythematosus
E Kassi, P Moutsatsou
Journal of biomedicine & biotechnology 2010
B cells require "nurturing" by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus
A Choudhury, PL Cohen, RA Eisenberg
Clinical Immunology 2010
The DTH effector response and IL-2 are unaffected by cyclosporine A in autoimmune B6D2F1 mice
H MacLeod, DG Goodwin, C Damphousse, E Lonie, X Xu, M Collins, CL Nickerson-Nutter
Cellular Immunology 2010
Current Clinical Medicine
F Al-Ashkar
Current Clinical Medicine 2010
Defectos en la síntesis de cadena ζ en el linfocito T, generando señales intracelulares equivocadas, responsables de lupus eritematoso sistémico
HS M., F Rondón, JF Restrepo, R Pérez, A Iglesias
Revista Colombiana de Reumatología 2010
Gene Therapy for Autoimmune and Inflammatory Diseases
Y Chernajovsky, PD Robbins
2010
Therapeutic Targets of the TNF Superfamily
IS Grewal
2009
Therapeutic Targets of the TNF Superfamily
IS Grewal
2009
Therapeutic Targets of the TNF Superfamily
IS Grewal
2009
Therapeutic Targets of the TNF Superfamily
IS Grewal
2009
Therapeutic Targets of the TNF Superfamily
IS Grewal
2009
Therapeutic Targets of the TNF Superfamily
IS Grewal
2009
Therapeutic Targets of the TNF Superfamily
IS Grewal
2009
Therapeutic Targets of the TNF Superfamily
IS Grewal
2009
Therapeutic Targets of the TNF Superfamily
IS Grewal
2009
Therapeutic Targets of the TNF Superfamily
IS Grewal
2009
The Multi-faceted Influences of Estrogen on Lymphocytes: Toward Novel Immuno-interventions Strategies for Autoimmunity Management
E Karpuzoglu, M Zouali
Clinical Reviews in Allergy & Immunology 2009
Serum levels of soluble CD40 ligand at flare and at remission in patients with systemic lupus erythematosus
M Urquizu-Padilla, E Balada, F Cortés, EH Pérez, M Vilardell-Tarrés, J Ordi-Ros
The Journal of rheumatology 2009
Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in systemic lupus erythematosus
SA Nicolaou, L Neumeier, K Takimoto, SM Lee, HJ Duncan, SK Kant, AB Mongey, AH Filipovich, L Conforti
Cell Calcium 2009
Regulatory T Cell (Treg) Subsets Return in Patients with Refractory Lupus following Stem Cell Transplantation, and TGF-β-Producing CD8 + Treg Cells Are Associated with Immunological Remission of Lupus
L Zhang, AM Bertucci, R Ramsey-Goldman, RK Burt, SK Datta
Journal of immunology (Baltimore, Md. : 1950) 2009
B-Cell-Directed Therapy for Inflammatory Skin Diseases
A Nagel, M Hertl, R Eming
Journal of Investigative Dermatology 2009
Peripheral B cell abnormalities in patients with systemic lupus erythematosus in quiescent phase: decreased memory B cells and membrane CD19 expression
AS Korganow, AM Knapp, H Nehme-Schuster, P Soulas-Sprauel, V Poindron, JL Pasquali, T Martin
Journal of Autoimmunity 2009
CD40 and autoimmunity: The dark side of a great activator
AL Peters, LL Stunz, GA Bishop
Seminars in Immunology 2009
Abnormal high-expression of CD154 on T lymphocytes of ankylosing spondylitis patients is down-regulated by etanercept treatment
Q Lin, Z Lin, J Gu, F Huang, T Li, Q Wei, Z Liao, S Cao, Y Jiang, J Huang
Rheumatology International 2009
Increased expression of CD154 and FAS in SLE patients’ lymphocytes
ME Manea, RB Mueller, D Dejica, A Sheriff, G Schett, M Herrmann, P Kern
Rheumatology International 2009
Increased expression of CD40 on bone marrow CD34+ hematopoietic progenitor cells in patients with systemic lupus erythematosus: Contribution to Fas-mediated apoptosis
K Pyrovolaki, I Mavroudi, P Sidiropoulos, AG Eliopoulos, DT Boumpas, HA Papadaki
Arthritis & Rheumatism 2009
Female predominance and X chromosome defects in autoimmune diseases
P Invernizzi, S Pasini, C Selmi, ME Gershwin, M Podda
Journal of Autoimmunity 2009
Post-transcriptional regulation in lymphocytes: the case of CD154
S Vavassori, LR Covey
RNA biology 2009
Cardiovascular risk assessment and treatment in systemic lupus erythematosus
JR Elliott, S Manzi
Best Practice & Research Clinical Rheumatology 2009
Treating lupus: from serendipity to sense, the rise of the new biologicals and other emerging therapies
E Sousa, D Isenberg
Best Practice & Research Clinical Rheumatology 2009
A review of the current use of rituximab in autoimmune diseases
HM Gürcan, DB Keskin, JN Stern, MA Nitzberg, H Shekhani, AR Ahmed
International Immunopharmacology 2009
Kelley's Textbook of Rheumatology
J Degroot, AM Zuurmond, PP Tak
Kelley's Textbook of Rheumatology 2009
BLyS Ligands and Receptors
MP Cancro
2009
CD44 high Memory CD8 T Cells Synergize with CpG DNA to Activate Dendritic Cell IL-12p70 Production
KL Wong, LF Tang, FC Lew, HS Wong, YL Chua, PA MacAry, DM Kemeny
Journal of immunology (Baltimore, Md. : 1950) 2009
Raised intrathecal levels of APRIL and BAFF in patients with systemic lupus erythematosus: relationship to neuropsychiatric symptoms
A George-Chandy, E Trysberg, K Eriksson
Arthritis Research & Therapy 2008
Systemic IFN‐α drives kidney nephritis in B6.Sle123mice
AM Fairhurst, A Mathian, JE Connolly, A Wang, HF Gray, TA George, CD Boudreaux, XJ Zhou, QZ Li, S Koutouzov, J Banchereau, EK Wakeland
European Journal of Immunology 2008
Not always the bad guys: B cells as regulators of autoimmune pathology
S Fillatreau, D Gray, SM Anderton
Nature Reviews Immunology 2008
Understanding Systemic Lupus Erythematosus Physiopathology in the Light of Primary Immunodeficiencies
M Carneiro-Sampaio, BL Liphaus, AA Jesus, CA Silva, JB Oliveira, MH Kiss
Journal of Clinical Immunology 2008
Autoimmunity in Hyper-IgM Syndrome
AA Jesus, AJ Duarte, JB Oliveira
Journal of Clinical Immunology 2008
X chromosome in autoimmune diseases
P Invernizzi, S Pasini, M Podda
Expert Review of Clinical Immunology 2008
CD40L-expressing CD8 T cells prime CD8α+DC for IL-12p70 production
KL Wong, FC Lew, PA MacAry, DM Kemeny
European Journal of Immunology 2008
How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype
JC Crispín, VC Kyttaris, YT Juang, GC Tsokos
Trends in Immunology 2008
Successful Treatment of Neuropsychiatric Syndrome with Rituximab in a Patient with Systemic Lupus Erythematosus and Dermatomyositis Overlap Syndrome
SG Lee, B Yoo, KM Kim, HO Choi, JS Oh, SS Nah, YG Kim, CK Lee
The Journal of the Korean Rheumatism Association 2008
The Relationship Between the Antiphospholipid Syndrome and Heparin-Induced Thrombocytopenia
DA Hoppensteadt, JM Walenga
Hematology/Oncology Clinics of North America 2008
Rituximab-induced B cell depletion in autoimmune diseases: Potential effects on T cells
SN Liossis, PP Sfikakis
Clinical Immunology 2008
The X in sex: how autoimmune diseases revolve around sex chromosomes
C Selmi
Best Practice & Research Clinical Rheumatology 2008
Lupus systémique : les traitements du futur
Z Amoura, J Haroche, JC Piette
La Revue de Médecine Interne 2008
CTL-Promoting Effects of CD40 Stimulation Outweigh B Cell-Stimulatory Effects Resulting in B Cell Elimination and Disease Improvement in a Murine Model of Lupus
R Puliaev, I Puliaeva, LA Welniak, AE Ryan, M Haas, WJ Murphy, CS Via
Journal of immunology (Baltimore, Md. : 1950) 2008
Splenic Phagocytes Promote Responses to Nucleosomes in (NZB × NZW) F 1 Mice
A Okamoto, K Fujio, N van Rooijen, NH Tsuno, K Takahashi, H Tsurui, S Hirose, KB Elkon, K Yamamoto
Journal of immunology (Baltimore, Md. : 1950) 2008
Demethylation of CD40LG on the inactive X in T cells from women with lupus
Q Lu, A Wu, L Tesmer, D Ray, N Yousif, B Richardson
Journal of immunology (Baltimore, Md. : 1950) 2007
Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration
T Harada, V Kyttaris, Y Li, YT Juang, Y Wang, GC Tsokos
Autoimmunity 2007
Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis
PP Sfikakis, VL Souliotis, KG Fragiadaki, HM Moutsopoulos, JN Boletis, AN Theofilopoulos
Clinical Immunology 2007
Abnormalities in lymphocyte telomerase activity and telomere length in systemic lupus erythematosus
D KUROSAKA
Japanese Journal of Clinical Immunology 2007
The role of preventive cardiology in systemic lupus erythematosus
JR Elliott, S Manzi, D Edmundowicz
Current Rheumatology Reports 2007
Hyperexpression of cyclooxygenase 2 in the lupus immune system and effect of cyclooxygenase 2 inhibitor diet therapy in a murine model of systemic lupus erythematosus
L Zhang, AM Bertucci, KA Smith, L Xu, SK Datta
Arthritis & Rheumatism 2007
Physiopathologie du lupus érythémateux systémique
P Blanco, JL Pellegrin, JF Moreau, JF Viallard
La Presse Médicale 2007
Contemporary Targeted Therapies in Rheumatology
P Lent, W Berg
Contemporary Targeted Therapies in Rheumatology 2007
Increased Levels of NF-ATc2 Differentially Regulate CD154 and IL-2 Genes in T Cells from Patients with Systemic Lupus Erythematosus
VC Kyttaris, Y Wang, YT Juang, A Weinstein, GC Tsokos
Journal of immunology (Baltimore, Md. : 1950) 2007
The role of preventive cardiology in systemic lupus erythematosus.
Elliott JR, Manzi S, Edmundowicz D
Current Rheumatology Reports 2007
Development of Autoimmunity in IL-14α-Transgenic Mice
L Shen, C Zhang, T Wang, S Brooks, RJ Ford, YC Lin-Lee, A Kasianowicz, V Kumar, L Martin, P Liang, J Cowell, JL Ambrus
Journal of immunology (Baltimore, Md. : 1950) 2006
Modification of accessory molecule signaling
MK Crow
Springer Seminars in Immunopathology 2006
Costimulatory molecules as immunotherapeutic targets in systemic lupus erythematosus
J Foell, RS Mittler
Springer Seminars in Immunopathology 2006
Systems biology in systemic lupus erythematosus: Integrating genes, biology and immune function
VC Kyttaris, S Krishnan, GC Tsokos
Autoimmunity 2006
Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus
L Colonna, JA Dinnall, DK Shivers, L Frisoni, R Caricchio, S Gallucci
Arthritis Research & Therapy 2006
FK506 controls CD40L-induced systemic autoimmunity in mice
K Loser, S Balkow, T Higuchi, J Apelt, A Kuhn, TA Luger, S Beissert
Journal of Investigative Dermatology 2006
Autoimmunity in systemic lupus erythematosus: Integrating genes and biology☆
S Krishnan, B Chowdhury, GC Tsokos
Seminars in Immunology 2006
The mechanisms of antinuclear antibody production and its pathogenicity in systemic autoimmune diseases
T FUJII
Japanese Journal of Clinical Immunology 2006
B cell depletion therapy in systemic lupus erythematosus: Effect on autoantibody and antimicrobial antibody profiles
G Cambridge, MJ Leandro, M Teodorescu, J Manson, A Rahman, DA Isenberg, JC Edwards
Arthritis & Rheumatism 2006
B-cell abnormality and systemic lupus erythematosus
T TSUBATA
APLAR Journal of Rheumatology 2006
A distinct inflammatory gene expression profile in patients with psoriatic arthritis
AK Stoeckman, EC Baechler, WA Ortmann, TW Behrens, CJ Michet, EJ Peterson
Genes and Immunity 2006
Update on the treatment of lupus nephritis
M Waldman, GB Appel
Kidney International 2006
Elevated levels of soluble CD40 ligand (sCD40L) in serum of patients with systemic autoimmune diseases
A Goules, AG Tzioufas, MN Manousakis, KA Kirou, MK Crow, JG Routsias
Journal of Autoimmunity 2006
BAFF, APRIL and human B cell disorders
SG Tangye, VL Bryant, AK Cuss, KL Good
Seminars in Immunology 2006
Cell-surface and cytokine biomarkers in autoimmune and inflammatory diseases
RM O’Hara, SE Benoit, CJ Groves, M Collins
Drug Discovery Today 2006
Premature atherosclerotic disease in systemic lupus erythematosus — role of inflammatory mechanisms
EY Rhew, R Ramsey-Goldman
Autoimmunity Reviews 2006
Intra-Vascular Ultrasound Findings of Diffuse Coronary Atherosclerotic Change in Systemic Lupus Erythematosus With Secondary Antiphospholipid Syndrome
Y Ikeda, S Yagi, H Yamaguchi, M Fujimura, S Hashizume, K Aihara, M Akaike, H Azuma, T Matsumoto
Circulation Journal 2006
T-cell-directed therapy in systemic lupus erythematosus
RW Hoffman
Future Rheumatology 2006
Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival
R Lesley, LM Kelly, Y Xu, JG Cyster
Proceedings of the National Academy of Sciences 2006
Systemic Lupus Erythematosus
M Petri
JCR: Journal of Clinical Rheumatology 2006
The Autoimmune Diseases
I Kang, J Craft
The Autoimmune Diseases 2006
Systemic lupus erythematosus: From disease pathogenesis to therapy
CG Katsiari, GC Tsokos
Drug Discovery Today: Disease Mechanisms 2006
Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease: Is CD4 T cell receptor ligation needed?
W Li, WR Green
Virology 2006
Estrogen does not regulate CD154 mRNA stability in systemic lupus erythematosus T cells
X Li, V Rider, BF Kimler, NI Abdou
Lupus 2006
Inflammation and the pathogenesis of atherosclerosis in systemic lupus erythematosus
M McMahon, J Grossman, W Chen, BH Hahn
Lupus 2006
Mycophenolate mofetil and cardiovascular disease
G Hughes, H Phillips
Lupus 2006
Increased Levels of Soluble CD40L in African Tick Bite Fever: Possible Involvement of TLRs in the Pathogenic Interaction between Rickettsia africae , Endothelial Cells, and Platelets
JK Damås, M Jensenius, T Ueland, K Otterdal, A Yndestad, SS Frøland, JM Rolain, B Myrvang, D Raoult, P Aukrust
Journal of immunology (Baltimore, Md. : 1950) 2006
Stability and Translation of TCR ζ mRNA Are Regulated by the Adenosine-Uridine-Rich Elements in Splice-Deleted 3′ Untranslated Region of ζ-Chain
B Chowdhury, S Krishnan, CG Tsokos, JW Robertson, CU Fisher, MP Nambiar, GC Tsokos
Journal of immunology (Baltimore, Md. : 1950) 2006
SLE serum IgG increase CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
Yuang-Taung Juang, Ying Wang, Elena E. Solomou, Yansong Li, Christian Mawrin, Klaus Tenbrock Vasileios C. Kyttaris, George C. Tsokos
Journal of Clinical Investigation 2005
IFN-α Induces Early Lethal Lupus in Preautoimmune (New Zealand Black × New Zealand White)F 1 but Not in BALB/c Mice
A Mathian, A Weinberg, M Gallegos, J Banchereau, S Koutouzov
Journal of immunology (Baltimore, Md. : 1950) 2005
T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigens
SK Datta, L Zhang, L Xu
Journal of Molecular Medicine 2005
Naive CD4 + T Cells from Lupus-Prone Fas-Intact MRL Mice Display TCR-Mediated Hyperproliferation Due to Intrinsic Threshold Defects in Activation
CE Zielinski, SN Jacob, F Bouzahzah, BE Ehrlich, J Craft
Journal of immunology (Baltimore, Md. : 1950) 2005
Autoimmune mechanisms in children with systemic lupus erythematosus
D Stichweh, V Pascual
Current Rheumatology Reports 2005
New therapies for systemic lupus erythematosus
F Goldblatt, DA Isenberg
Clinical & Experimental Immunology 2005
Monoclonal antibodies and fusion proteins in medicine
SN Liossis, GC Tsokos
Journal of Allergy and Clinical Immunology 2005
Cardiovascular disease in systemic lupus erythematosus: has the time for action come?
SI van Leuven, JJ Kastelein, MR Hayden, D dʼCruz, GR Hughes, ES Stroes
Current Opinion in Lipidology 2005
Anti-CD20 therapy in systemic lupus erythematosus: A step closer to the clinic
GJ Silverman
Arthritis & Rheumatism 2005
Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: An open-label trial
PP Sfikakis, JN Boletis, S Lionaki, V Vigklis, KG Fragiadaki, A Iniotaki, HM Moutsopoulos
Arthritis & Rheumatism 2005
Rituximab anti-B-cell therapy in systemic lupus erythematosus: pointing to the future
PP Sfikakis, JN Boletis, GC Tsokos
Current Opinion in Rheumatology 2005
Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer
A Nakamura, K Akiyama, T Takai
Expert Opinion on Therapeutic Targets 2005
Study of Plasma Levels of Soluble CD40 Ligand in Systemic Lupus Erythematosus Patients Who Have Undergone Plasmapheresis
K Kimura, H Tsuda, Y Kwangseok, N Tamura, Y Kanai, S Kobayashi
Therapeutic Apheresis and Dialysis 2005
Spotlight on the role of hormonal factors in the emergence of autoreactive B-lymphocytes
E Peeva, M Zouali
Immunology Letters 2005
Effects of sex hormones on costimulatory molecule expression in multiple sclerosis
CM Pelfrey, IR Moldovan, AC Cotleur, N Zamor, RA Rudick
Journal of Neuroimmunology 2005
Rituximab anti-B-cell therapy in systemic lupus erythematosus: pointing to the future:
PP Sfikakis, JN Boletis, GC Tsokos
Current Opinion in Rheumatology 2005
B cell abnormality and autoimmune disorders
T Tsubata
Autoimmunity 2005
Increased prevalence of activated CD70+CD4+ T cells in the periphery of patients with systemic lupus erythematosus
BK Han, AM White, KH Dao, DR Karp, EK Wakeland, LS Davis
Lupus 2005
CD40 Ligand Expression Correlates with Resolution of Peritonitis and Mononuclear Cell Recruitment
A Glik, J Mazar, B Rogachev, M Zlotnik, A Douvdevani
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2005
Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
Juang YT, Wang Y, Solomou EE, Li Y, Mawrin C, Tenbrock K, Kyttaris VC, Tsokos GC
Journal of Clinical Investigation 2005
Ectopic CD40 ligand expression on B cells triggers intestinal inflammation
T Kawamura, T Kanai, T Dohi, K Uraushihara, T Totsuka, R Iiyama, C Taneda, M Yamazaki, T Nakamura, T Higuchi, Y Aiba, T Tsubata, M Watanabe
Journal of immunology (Baltimore, Md. : 1950) 2004
Nucleosome-specific regulatory T cells engineered by triple gene transfer suppress a systemic autoimmune disease
K Fujio, A Okamoto, H Tahara, M Abe, Y Jiang, T Kitamura, S Hirose, K Yamamoto
Journal of immunology (Baltimore, Md. : 1950) 2004
Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus
JH Anolik, J Barnard, A Cappione, AE Pugh-Bernard, RE Felgar, RJ Looney, I Sanz
Arthritis & Rheumatism 2004
Targeting CD40L: a promising therapeutic approach
D Daoussis, AP Andonopoulos, SN Liossis
Clinical and diagnostic laboratory immunology 2004
Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors
K Oelke, Q Lu, D Richardson, A Wu, C Deng, S Hanash, B Richardson
Arthritis & Rheumatism 2004
DECREASED T CELL ERK PATHWAY SIGNALING MAY CONTRIBUTE TO THE DEVELOPMENT OF LUPUS THROUGH EFFECTS ON DNA METHYLATION AND GENE EXPRESSION
K Oelke, B Richardson
International Reviews of Immunology 2004
A new CD21low B cell population in the peripheral blood of patients with SLE
C Wehr, H Eibel, M Masilamani, H Illges, M Schlesier, HH Peter, K Warnatz
Clinical Immunology 2004
Involvement of CD40-CD154 interaction in immunopathogenesis of collagen diseases and its application to a novel therapeutic strategy
M HARIGAI
Japanese Journal of Clinical Immunology 2004
Update on pediatric systemic lupus erythematosus
D Stichweh, E Arce, V Pascual
Current Opinion in Rheumatology 2004
Recent advances in vascular inflammation: C-reactive protein and other inflammatory biomarkers
K Maksimowicz-McKinnon, DL Bhatt, LH Calabrese
Current Opinion in Rheumatology 2004
IL-10 production in B cells is confined to CD154+ cells in patients with systemic lupus erythematosus
A Díaz-Alderete, JC Crispin, MI Vargas-Rojas, J Alcocer-Varela
Journal of Autoimmunity 2004
Human immunodeficiency virus (HIV) type 1 Vpu induces the expression of CD40 in endothelial cells and regulates HIV-induced adhesion of B-lymphoma cells
WW Henderson, R Ruhl, P Lewis, M Bentley, JA Nelson, AV Moses
Journal of virology 2004
The dinucleotide repeat polymorphism in the 3'UTR of the CD154 gene has a functional role on protein expression and is associated with systemic lupus erythematosus
MJ Citores, I Rua-Figueroa, C Rodriguez-Gallego, A Durántez, MI García-Laorden, C Rodríguez-Lozano, JC Rodríguez-Pérez, JA Vargas, P Pérez-Aciego
Annals of the rheumatic diseases 2004
Costimulatory molecules and T-cell–B-cell interactions
MK Crow
Rheumatic Disease Clinics of North America 2004
Regulation of immune function by calorie restriction and cyclophosphamide treatment in lupus-prone NZB/NZW F1 mice
D Sun, A Krishnan, J Su, R Lawrence, K Zaman, G Fernandes
Cellular Immunology 2004
Down-regulation of CD40 and CD80 on B cells in patients with life-threatening systemic lupus erythematosus after successful treatment with rituximab
M Tokunaga, K Fujii, K Saito, S Nakayamada, S Tsujimura, M Nawata, Y Tanaka
Rheumatology 2004
Biomarkers in systemic lupus erythematosus: II. Markers of disease activity
GG Illei, E Tackey, L Lapteva, PE Lipsky
Arthritis & Rheumatism 2004
Update on pediatric systemic lupus erythematosus:
D Stichweh, E Arce, V Pascual
Current Opinion in Rheumatology 2004
Costimulation Blockade in the Treatment of Rheumatic Diseases:
SN Liossis, PP Sfikakis
BioDrugs 2004
Principles of Gender-Specific Medicine
G Supinski, LA Callahan
Principles of Gender-Specific Medicine 2004
Pathogenesis of SLE: implications for rational therapy
G Franchin, E Peeva, B Diamond
Drug Discovery Today: Disease Mechanisms 2004
Autoimmunity through Cytokine-Induced Dendritic Cell Activation
J Banchereau, V Pascual, AK Palucka
Immunity 2004
Ongoing Immunoglobulin Class Switch DNA Recombination in Lupus B Cells: Analysis of Switch Regulatory Regions
S Liu, A Cerutti, P Casali, MK Crow
Autoimmunity 2004
Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients
PI Sidiropoulos, DT Boumpas
Lupus 2004
Re-establishment of tolerance: the prospect of developing specific treatment for human lupus
CG Katsiari, GC Tsokos
Lupus 2004
The role of CD40 ligand in systemic lupus erythematosus
J Yazdany, J Davis
Lupus 2004
Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus
AM Jacobi, M Odendahl, K Reiter, A Bruns, GR Burmester, A Radbruch, G Valet, PE Lipsky, T Dörner
Arthritis & Rheumatism 2003
The naive B cell repertoire predisposes to antigen-induced systemic lupus erythematosus
C Wang, M Khalil, J Ravetch, B Diamond
Journal of immunology (Baltimore, Md. : 1950) 2003
Effects of anti-CD154 treatment on B cells in murine systemic lupus erythematosus
X Wang, W Huang, LE Schiffer, M Mihara, A Akkerman, K Hiromatsu, A Davidson
Arthritis & Rheumatism 2003
Therapeutic CD154 antibody for lupus: promise for the future?
G Kelsoe
Journal of Clinical Investigation 2003
B cell depletion therapy in systemic lupus erythematosus
J Anolik, I Sanz, RJ Looney
Current Rheumatology Reports 2003
Major Peptide Autoepitopes for Nucleosome-Centered T and B Cell Interaction in Human and Murine Lupus
SK Datta
Annals of the New York Academy of Sciences 2003
Monocyte response to Th1 stimulation and effector function toward human mesangial cells are not impaired in patients with lupus nephritis
T Kuroiwa, R Schlimgen, GG Illei, DT Boumpas
Clinical Immunology 2003
The CD40–CD154 interaction in B cell–T cell liaisons
GA Bishop, BS Hostager
Cytokine & Growth Factor Reviews 2003
Differential regulation of Th1 responses and CD154 expression in human CD4+ T cells by IFN-alpha
H Shibuya, T Nagai, A Ishii, K Yamamoto, S Hirohata
Clinical & Experimental Immunology 2003
A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
DT Boumpas, R Furie, S Manzi, GG Illei, DJ Wallace, JE Balow, A Vaishnaw
Arthritis & Rheumatism 2003
Update on vascular disease in systemic lupus erythematosus
AH Kao, JM Sabatine, S Manzi
Current Opinion in Rheumatology 2003
CD154 expression and mRNA stability of activated CD4-positive T cells in patients with systemic lupus erythematosus
M Takaya, N Tamura, K Kato, S Kobayashi, K Haruta, M Tajima, M Hara, KS Yang, H Tsuda, H Hashimoto
Modern Rheumatology 2003
Immunopathology and the gene therapy of lupus
RA Mageed, GJ Prud'homme
Gene Therapy 2003
Cytokines and Chemokines in Autoimmune Disease
P Santamaria
2003
Lack of the Transcriptional Coactivator OBF-1 Prevents the Development of Systemic Lupus Erythematosus-Like Phenotypes in Aiolos Mutant Mice
J Sun, G Matthias, MJ Mihatsch, K Georgopoulos, P Matthias
Journal of immunology (Baltimore, Md. : 1950) 2003
CD4 + T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo
F Bouzahzah, S Jung, J Craft
Journal of immunology (Baltimore, Md. : 1950) 2003
CD40, but Not CD154, Expression on B Cells Is Necessary for Optimal Primary B Cell Responses
BO Lee, J Moyron-Quiroz, J Rangel-Moreno, KL Kusser, L Hartson, F Sprague, FE Lund, TD Randall
Journal of immunology (Baltimore, Md. : 1950) 2003
CD154 Transcriptional Regulation in Primary Human CD4 T Cells
RQ Cron
Immunologic Research 2003
The effect of anti-CD40 ligand antibody on B cells in human systemic lupus erythematosus
W Huang, J Sinha, J Newman, B Reddy, L Budhai, R Furie, A Vaishnaw, A Davidson
Arthritis & Rheumatism 2002
New therapies in systemic lupus erythematosus
MA Solsky, DJ Wallace
Best Practice & Research Clinical Rheumatology 2002
Suppressor of Cytokine Signaling 1 Inhibits Cytokine Induction of CD40 Expression in Macrophages
DR Wesemann, Y Dong, GM OKeefe, VT Nguyen, EN Benveniste
Journal of immunology (Baltimore, Md. : 1950) 2002
Novel therapeutic agents for systemic lupus erythematosus
BD Gescuk, JC Davis
Current Opinion in Rheumatology 2002
Malignancy and systemic lupus erythematosus
S Bernatsky, A Clarke, R Ramsey-Goldman
Current Rheumatology Reports 2002
CD154-CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosus
AC Grammer, PE Lipsky
Arthritis & Rheumatism 2002
Aberrant Expression of the Costimulatory Molecule CD40 Ligand on Monocytes from Patients with Systemic Lupus Erythematosus
CG Katsiari, SN Liossis, VL Souliotis, AM Dimopoulos, MN Manoussakis, PP Sfikakis
Clinical Immunology 2002
B Cell Stimulatory Effects of α-Enolase That Is Differentially Expressed in NZB Mouse B Cells
JS Babu, T Sun, L Xu, SK Datta
Clinical Immunology 2002
Isolation and Functional Analysis of Autoreactive T cells from BXSB Mice with Murine Lupus
SH Han, B Li, YT Chen, XM Gao
Journal of Autoimmunity 2002
The transmembrane form of TNF-alpha drives autoantibody production in the absence of CD154: studies using MRL/Mp-Fas(lpr) mice
T Fujii, M Okada, T Mimori, J Craft
Clinical & Experimental Immunology 2002
Abnormal T cell signal transduction in systemic lupus erythematosus
GM Kammer, A Perl, BC Richardson, GC Tsokos
Arthritis & Rheumatism 2002
Lupus eritematoso sistémico y enfermedad cardiovascular
S Jiménez, J Font, M Ingelmo
Medicina Clínica 2002
CD40L overexpression on T cells and monocytes from patients with systemic lupus erythematosus is resistant to calcineurin inhibition
CG Katsiari, SN Liossis, AM Dimopoulos, DV Charalambopoulos, M Mavrikakis, PP Sfikakis
Lupus 2002
Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosus
HJ Girschick, AC Grammer, T Nanki, E Vazquez, PE Lipsky
Arthritis & Rheumatism 2002
Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: A randomized, double-blind, placebo-controlled trial
KC Kalunian, JC Davis, JT Merrill, MC Totoritis, D Wofsy
Arthritis & Rheumatism 2002
CD154 is expressed during treatment with calcineurin inhibitors after organ transplantation:
MM van Rijen, ML Kuijf, HJ Metselaar, HW Tilanus, GJ Bouma, RA de Weger, M Jonker, J Kwekkeboom
Transplantation 2002
Cutting Edge: Ectopic Expression of CD40 Ligand on B Cells Induces Lupus-Like Autoimmune Disease
T Higuchi, Y Aiba, T Nomura, J Matsuda, K Mochida, M Suzuki, H Kikutani, T Honjo, K Nishioka, T Tsubata
Journal of immunology (Baltimore, Md. : 1950) 2002
CD40, CD154, Bax and Bcl -2 Expression in Sjögren's Syndrome Salivary Glands: a Putative Anti-Apoptotic Role During its Effector Phases: CD40, CD154, Bax and Bcl-2 in Sjögren's Syndrome
M Ohlsson, P Szodoray, LL Loro, AC Johannessen, R Jonsson
Scandinavian Journal of Immunology 2002
Does CD40 Ligation Induce B Cell Negative Selection?
J Martínez-Barnetche, V Madrid-Marina, RA Flavell, J Moreno
Journal of immunology (Baltimore, Md. : 1950) 2002
Long-term anti-CD154 dosing in nephritic mice is required to maintain survival and inhibit mediators of renal fibrosis
SL Kalled, AH Cutler, JL Ferrant
Lupus 2001
Crossreactivity of Human Anti-dsDNA Antibodies to Phosphorylcholine: Clues to Their Origin
A Sharma, DA Isenberg, B Diamond
Journal of Autoimmunity 2001
Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus
E Arce, DG Jackson, MA Gill, LB Bennett, J Banchereau, V Pascual
Journal of immunology (Baltimore, Md. : 1950) 2001
Regulation of CD40 ligand expression in systemic lupus erythematosus
MK Crow, KA Kirou
Current Opinion in Rheumatology 2001
Novel approaches in the treatment of lupus nephritis
L Czirják, GG Illei
Expert Opinion on Investigational Drugs 2001
Expression of CD40 and CD40 Ligand among Cell Populations within Rheumatoid Synovial Compartment
MF Liu, SC Chao, CR Wang, HY Lei
Autoimmunity 2001
ADVANCES IN THETREATMENT OFLUPUSNEPHRITIS
R Zimmerman, J Radhakrishnan, A Valeri, G Appel
Annual Review of Medicine 2001
Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells
N Mishra, DR Brown, IM Olorenshaw, GM Kammer
Proceedings of the National Academy of Sciences 2001
Multiple cytokines sharing the common receptor gamma chain can induce CD154/CD40 ligand expression by human CD4+ T lymphocytes via a cyclosporin A-resistant pathway
JD Fayen
Immunology 2001
NF-kappaB is involved in the regulation of CD154 (CD40 ligand) expression in primary human T cells
M Srahna, JE Remacle, K Annamalai, S Pype, D Huylebroeck, MA Boogaerts, P Vandenberghe
Clinical & Experimental Immunology 2001
POTENTIAL BIOLOGIC AGENTS FOR TREATING RHEUMATOID ARTHRITIS
LW Moreland
Rheumatic Disease Clinics of North America 2001
Functional properties of lymphocytes in idiopathic thrombocytopenic purpura
NP Webber, JO Mascarenhas, MK Crow, J Bussel, EJ Schattner
Human Immunology 2001
Analysis of the CD40/CD40L role in the sustenance of alloreactive antibody production
AS Shoker, ZR Lun, R Choudry, A Saxena
Transplant Immunology 2001
Atherosclerosis and Autoimmunity
EC Lau
Atherosclerosis and Autoimmunity 2001
The Cytokine FactsBook and Webfacts
KA Fitzgerald, LA O'Neill, AJ Gearing, RE Callard
The Cytokine FactsBook and Webfacts 2001
Telomeres, Telomerase, and Lupus: The Long and Short of It
V Rus, CS Via
Clinical Immunology 2001
T cell activation following infection of primary follicle center lymphoma B cells with adenovirus encoding CD154
MJ Cantwell, WG Wierda, IS Lossos, R Levy, TJ Kipps
Leukemia 2001
Apoptosis and Altered Dendritic Cell Homeostasis in Lupus Nephritis Are Limited by Anti-CD154 Treatment
SL Kalled, AH Cutler, LC Burkly
Journal of immunology (Baltimore, Md. : 1950) 2001
Evaluation of chronic urticaria in patients with Hashimoto thyroiditis
A A Kandeel, M Zeid, T Helm, M A Lillie, E Donahue, J L Ambrus Jr
Journal of Clinical Immunology 2001
TGF-beta1 null mutation leads to CD154 upregulated expression in affected tissues
T Nakabayashi, K M Sakata, A Sakata, L Kong, C A Lau, J J Letterio, N Vela-Roch, N Talal, H Dang
Inflammation 2001
B Cells from Autoimmune BXSB Mice are Hyporesponsive to Signals Provided by CD4+T Cells
SJ Blossom, KM Gilbert
Immunological Investigations 2000
T cells in the pathogenesis of systemic lupus erythematosus: Potential roles of CD154-CD40 interactions and costimulatory molecules
MJ Yellin, U Thienel
Current Rheumatology Reports 2000
Clinical trials in systemic lupus erythematosus
JP Buyon
Current Rheumatology Reports 2000
Dehydroepiandrosterone and biologics in the treatment of systemic lupus erythematosus
R Furie
Current Rheumatology Reports 2000
MHC Class II Associations with Autoantibody and T cell Immune Responses to the Scleroderma Autoantigen Topoisomerase I
AL Rands, J Whyte, B Cox, ND Hall, NJ McHugh
Journal of Autoimmunity 2000
Immune cell signaling in lupus
GC Tsokos, HK Wong, EJ Enyedy, MP Nambiar
Current Opinion in Rheumatology 2000
Progress in the treatment of proliferative lupus nephritis
JE Balow, HA Austin
Current Opinion in Nephrology and Hypertension 2000
CD154 polymorphism in Spanish populations. Differences in the allelic distribution between Canary Islanders and Peninsulars
MJ Citores, P Perez-Aciego, C Rodriguez-Gallego, B Contreras-Martin, I Garcia-Laorden, A Durantez
European Journal of Immunogenetics 2000
Elevated CD40 Ligand Expressing Blood T-Cell Levels in Multiple Sclerosis Are Reversed by Interferon-Beta Treatment
Teleshova, Bao, Kivisakk, Ozenci, Mustafa, Link
Scandinavian Journal of Immunology 2000
An increased number of CD40-high monocytes in patients with Crohn's disease
N Sawada-Hase, T Kiyohara, J Miyagawa, H Ueyama, H Nishibayashi, Y Murayama, T Kashihara, M Nakahara, Y Miyazaki, S Kanayama, R Nezu, Y Shinomura, Y Matsuzawa
The American Journal of Gastroenterology 2000
CD40 Ligand in CLL Pathogenesis and Therapy
EJ Schattner
Leukemia & Lymphoma 2000
Increased expression of CD40 ligand (CD154) on CD4+ T cells as a marker of disease activity in rheumatoid arthritis
B Berner, G Wolf, KM Hummel, GA Müller, MA Reuss-Borst
Annals of the rheumatic diseases 2000
Fortifying B cells with CD154: an engaging tale of many hues
J Gordon, JD Pound
Immunology 2000
Inflammation-mediated rheumatic diseases and atherosclerosis
S Manzi, MC Wasko
Annals of the rheumatic diseases 2000
Cytokines and systemic lupus erythematosus
GS Dean, J Tyrrell-Price, E Crawley, DA Isenberg
Annals of the rheumatic diseases 2000
GENETICS OF SYSTEMIC LUPUS ERYTHEMATOSUS
KE Sullivan
Rheumatic Disease Clinics of North America 2000
Transcriptional Activity of the Distal CD40 Ligand Promoter
FM Lobo, S Xu, C Lee, RL Fuleihan
Biochemical and Biophysical Research Communications 2000
Molecular aberrations in human systemic lupus erythematosus
GC Tsokos, GM Kammer
Molecular Medicine Today 2000
Women and Health
R Ramsey-Goldman, S Manzi
Women and Health 2000
Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity:
R Cavaleiro, AE Sousa, A Loureiro, RM Victorino
AIDS 2000
Systemic lupus erythematosus—messages from experimental models
ML Stoll, J Gavalchin
Rheumatology (Oxford, England) 2000
Intravenous cyclophosphamide in SLE
E Toubi, A Kessel
Lupus 2000
Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice
T Yoshida, T Higuchi, H Hagiyama, A Strasser, K Nishioka, T Tsubata
International Immunology 2000
Effect of intravenous cyclophosphamide in systemic lupus erythematosus: relation to lymphocyte subsets and activation markers
H Amano, S Morimoto, H Kaneko, Y Tokano, Y Takasaki, H Hashimoto
Lupus 2000
Positive selection for autoimmunity
SK Datta
Nature Medicine 2000
HEIGHTENED CD40 LIGAND GENE EXPRESSION IN PERIPHERAL CD4+ T CELLS FROM PATIENTS WITH KIDNEY ALLOGRAFT REJECTION:
A Shoker, D George, H Yang, M Baltzan
Transplantation 2000
Human Double-Negative T Cells in Systemic Lupus Erythematosus Provide Help for IgG and Are Restricted by CD1c
PA Sieling, SA Porcelli, BT Duong, F Spada, BR Bloom, B Diamond, BH Hahn
Journal of immunology (Baltimore, Md. : 1950) 2000
Regulatory Defects in Cbl and Mitogen-Activated Protein Kinase (Extracellular Signal-Related Kinase) Pathways Cause Persistent Hyperexpression of CD40 Ligand in Human Lupus T Cells
Y Yi, M McNerney, SK Datta
Journal of immunology (Baltimore, Md. : 1950) 2000
CD4 + T Lymphocytes with Constitutive CD40 Ligand in Preautoimmune (NZB × NZW)F 1 Lupus-Prone Mice: Phenotype and Possible Role in Autoreactivity
H Lettesjö, GP Burd, RA Mageed
Journal of immunology (Baltimore, Md. : 1950) 2000
Sustained Expression of CD154 (CD40L) and Proinflammatory Cytokine Production by Alloantigen-Stimulated Umbilical Cord Blood T Cells
NC Matthews, M Wadhwa, C Bird, FE Borras, CV Navarrete
Journal of immunology (Baltimore, Md. : 1950) 2000
Strong and Selective Glomerular Localization of CD134 Ligand and TNF Receptor-1 in Proliferative Lupus Nephritis
J Aten, A Roos, N Claessen, EJ Schilder-Tol, IJ Berge, JJ Weening
Journal of the American Society of Nephrology : JASN 2000
Prevention of Experimental Colitis in SCID Mice Reconstituted with CD45RB high CD4 + T Cells by Blocking the CD40-CD154 Interactions
Z Liu, K Geboes, S Colpaert, L Overbergh, C Mathieu, H Heremans, M de Boer, L Boon, G DHaens, P Rutgeerts, JL Ceuppens
Journal of immunology (Baltimore, Md. : 1950) 2000
Immune aberrations in B and T lymphocytes derived from chronic urticaria patients
E Toubi, A Adir-Shani, A Kessel, Z Shmuel, E Sabo, H Hacham
Journal of Clinical Immunology 2000
Major peptide autoepitopes for nucleosome-specific T cells of human lupus
L Lu, A Kaliyaperumal, DT Boumpas, SK Datta
Journal of Clinical Investigation 1999
The soluble CD40 ligand sCD154 in systemic lupus erythematosus
K Kato, E Santana-Sahagún, LZ Rassenti, MH Weisman, N Tamura, S Kobayashi, H Hashimoto, TJ Kipps
Journal of Clinical Investigation 1999
Autoreactive T cells in murine lupus
J Craft, S Peng, T Fujii, M Okada, S Fatenejad
Immunologic Research 1999
Synergistic effect of interleukin-1 and CD40L on the activation of human renal tubular epithelial cells
CV Kooten, XV der Linde, AM Woltman, LA van Es, MR Daha
Kidney International 1999
Vasculitides secondary to systemic diseases
AD Rosso, S Generini, A Pignone, M Matucci-Cerinic
Clinics in Dermatology 1999
Apoptosis of Mature B Cells
T Tsubata
International Reviews of Immunology 1999
Antibody production in autoimmune BXSB mice. I. CD40L-expressing B cells need fewer signals for polyclonal antibody synthesis
S Blossom, KM Gilbert
Clinical & Experimental Immunology 1999
Soluble CD40 in the serum of healthy donors, patients with chronic renal failure, haemodialysis and chronic ambulatory peritoneal dialysis (CAPD) patients
RF Schwabe, H Engelmann, S Hess, H Fricke
Clinical & Experimental Immunology 1999
Early reduction of the over-expression of CD40L, OX40 and Fas on T cells in HIV-1 infection during triple anti-retroviral therapy: possible implications for lymphocyte traffic and functional recovery
AE Sousa, AF Chaves, M Doroana, F Antunes, RM Victorino
Clinical & Experimental Immunology 1999
Autoreactive T cells in murine lupus: Origins and Roles in Autoantibody Production
J Craft, S Peng, T Fujii, M Okada, S Fatenejad
Immunologic Research 1999
Immune cell signaling defects in lupus: activation, anergy and death
GC Tsokos, SN Liossis
Immunology Today 1999
Regulation of CD40L Expression by Cyclic AMP: Contrasting Proinflammatory and Inhibitory Actions
DG Wingett, K Forcier, CP Nielson
Cellular Immunology 1999
High prevalence of T cell type I protein kinase a deficiency in systemic lupus erythematosus
GM Kammer
Arthritis & Rheumatism 1999
Responsiveness of peripheral blood B cells to recombinant CD40 ligand in patients with systemic lupus erythematosus
M Harigai, M Hara, C Fukasawa, S Nakazawa, Y Kawaguchi, N Kamatani, S Kashiwazaki
Lupus 1999
PRODUCTION OF HUMAN ALLOREACTIVE ANTIBODIES BY UREMIC SENSITIZED LYMPHOCYTES ENGRAFTED IN SEVERE COMBINED IMMUNODEFICIENT MICE:
A Shoker, Z Sardar, H Yang, M Hussain
Transplantation 1999
Immune cell signaling aberrations in human lupus
SN Liossis, PP Sfikakis, GC Tsokos
Immunologic Research 1998
Immunotherapy for autoimmune and inflammatory renal diseases
DR Jayne
Current Opinion in Nephrology and Hypertension 1998
Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus)
JD Laman, M Meurs, MM Schellekens, M Boer, B Melchers, L Massacesi, H Lassmann, E Claassen, BA Hart
Journal of Neuroimmunology 1998
Cellular interactions in the pathogenesis of lupus nephritis: The role of T cells and macrophages in the amplification of the inflammatory process in the kidney
T Kuroiwa, EG Lee
Lupus 1998
Production of pathogenic antibodies: Cognate interactions between autoimmune T and B cells
SK Datta
Lupus 1998
Defective early T and T-dependent B cell activation in systemic lupus erythematosus
B Fernández-Gutiérrez, S Miguel, C Morado, C Hernández-García, A Bañares, JA Jover
Lupus 1998
Chronic Lymphocytic Leukemia B Cells Can Express CD40 Ligand and Demonstrate T-Cell Type Costimulatory Capacity
EJ Schattner, J Mascarenhas, I Reyfman, M Koshy, C Woo, SM Friedman, MK Crow
Blood 1998
Functional CD40 ligand is expressed by T cells in rheumatoid arthritis
KP MacDonald, Y Nishioka, PE Lipsky, R Thomas
Journal of Clinical Investigation 1997
Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand
L Georgescu, RK Vakkalanka, KB Elkon, MK Crow
Journal of Clinical Investigation 1997
Systemic lupus: basic mechanisms and prospects for specific immunotherapy
SK Datta
Japanese Journal of Rheumatology 1997
Nucleosome-driven Autoimmune Response in Lupus Pathogenic T Helper Cell Epitopes and Costimulatory Signals
SK Datta, A Kaliyaperumal
Annals of the New York Academy of Sciences 1997
Requirement of a second signal via protein kinase C or protein kinase A for maximal expression of CD40 ligand. Involvement of transcriptional and posttranscriptional mechanisms
A Suárez, L Mozo, A Gayo, J Zamorano, C Gutierrez
European Journal of Immunology 1997
Immunohistologic analysis of renal CD40 and CD40L expression in lupus nephritis and other glomerulonephritides
MJ Yellin, V D'Agati, G Parkinson, AS Han, A Szema, D Baum, D Estes, M Szabolcs, L Chess
Arthritis & Rheumatism 1997
Advances in Molecular and Cell Biology
KJ Clemetson
Advances in Molecular and Cell Biology 1997
Self antigens and epitope spreading in systemic autoimmunity
J Craft, S Fatenejad
Arthritis & Rheumatism 1997
CD40-CD40 ligand interaction in autoimmune disease
SK Datta, SL Kalled
Arthritis & Rheumatism 1997
Low-Level Production of Interleukin-13 in Synovial Fluid and Tissue from Patients with Arthritis
JM Woods, GK Haines, MR Shah, G Rayan, AE Koch
Clinical Immunology and Immunopathology 1997
Reed-Sternberg Cells and the TNF Family of Receptors/Ligands
K Clodi, A Younes
Leukemia & Lymphoma 1997
T helper cells driving pathogenic anti-DNA autoantibody production in lupus : nucleosomal epitopes and CD40 ligand signals
SK Datta, A Kaliyaperumal, C Mohan, A Desai-Mehta
Lupus 1997
T cells of lupus and molecular targets for immunotherapy
S K Datta, A Kaliyaperumal, A Desai-Mehta
Journal of Clinical Immunology 1997
Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus
A Kaliyaperumal, C Mohan, W Wu, SK Datta
Journal of Experimental Medicine 1996

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