We investigated the role of the costimulatory molecules, CD40 and its ligand CD40L, in the pathogenesis of human SLE. In comparison to normal subjects or patients in remission, PBMC from active lupus patients had a 21-fold increase in the frequency of CD40L-expressing, CD4+T cells. However, the expression of CD40L induced in either lupus or normal T cells by mitogenic stimulation could be down-regulated equally well by CD40 molecules on autologous B cells. Active lupus patients also had a 22-fold increase in percentage of CD8+ T cells expressing CD40L, consistent with their unusual helper activity in SLE. Surprisingly, patients with active lupus had a 20.5-fold increase in B cells that spontaneously expressed high levels of CD40L, as strongly as their T cells. Although lupus patients in remission had low levels of CD40L+ cells in the range of normal subjects, mitogen-induced upregulation of CD40L expression in the T and B cells was markedly greater than normal, suggesting an intrinsic defect. A mAb to CD40L blocked significantly the ability of lymphocytes from lupus patients with active and established disease to produce the pathogenic variety of antinuclear autoantibodies in vitro, bolstering the possibility of anti-CD40L immunotherapy for lupus. Future studies on the hyperexpression of CD40L could elucidate a regulatory defect in the pathogenic T and B cells of lupus.
A Desai-Mehta, L Lu, R Ramsey-Goldman, S K Datta
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Megakaryocyte progenitors are the main APCs inducing Th17 response to lupus autoantigens and foreign antigens
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JW Semple |
ISBT Science Series | 2012 |
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Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus
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Y Du, C Mohan |
Systemic Lupus Erythematosus | 2011 |
Origins of Antinuclear Antibodies
WH Reeves, Y Xu, H Zhuang, Y Li, L Yang |
Systemic Lupus Erythematosus | 2011 |
Anti-DNA Antibodies: Structure, Regulation and Pathogenicity
C Aranow, D Zhou, B Diamond |
Systemic Lupus Erythematosus | 2011 |
Amplified B Lymphocyte CD40 Signaling Drives Regulatory B10 Cell Expansion in Mice
JC Poe, SH Smith, KM Haas, K Yanaba, T Tsubata, T Matsushita, TF Tedder, WN Khan |
PloS one | 2011 |
Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas
A Bolduc, E Long, D Stapler, M Cascalho, T Tsubata, PA Koni, M Shimoda |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
Augmented Antibody Response with Premature Germinal Center Regression in CD40L Transgenic Mice
Y Kishi, Y Aiba, T Higuchi, K Furukawa, T Tokuhisa, T Takemori, T Tsubata |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
Monocyte and Macrophage Abnormalities in Systemic Lupus Erythematosus
Y Li, PY Lee, WH Reeves |
Archivum Immunologiae et Therapiae Experimentalis | 2010 |
T cells as therapeutic targets in SLE
JC Crispín, VC Kyttaris, C Terhorst, GC Tsokos |
Nature Reviews Rheumatology | 2010 |
Regulatory B cells in autoimmune diseases and mucosal immune homeostasis
X Li, J Braun, B Wei |
Autoimmunity | 2010 |
Systems Biology in Drug Discovery and Development
Q Yan |
2010 | |
Systems Biology in Drug Discovery and Development
Q Yan |
2010 | |
Systems Biology in Drug Discovery and Development
Q Yan |
2010 | |
Phenotypic Changes of Lymphocytes in Patients with Systemic Lupus Erythematosus Who Are in Longterm Remission After B Cell Depletion Therapy with Rituximab
S IWATA, K SAITO, M TOKUNAGA, K YAMAOKA, M NAWATA, S YUKAWA, K HANAMI, S FUKUYO, I MIYAGAWA, S KUBO, Y TANAKA |
The Journal of rheumatology | 2010 |
Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: Past, present, and future
N Jacob, W Stohl |
Autoimmunity | 2010 |
Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritis
J Mehta, A Genin, M Brunner, LV Scalzi, N Mishra, T Beukelman, RQ Cron |
Arthritis & Rheumatism | 2010 |
Platelet CD154 Potentiates Interferon- Secretion by Plasmacytoid Dendritic Cells in Systemic Lupus Erythematosus
P Duffau, J Seneschal, C Nicco, C Richez, E Lazaro, I Douchet, C Bordes, JF Viallard, C Goulvestre, JL Pellegrin, B Weil, JF Moreau, F Batteux, P Blanco |
Science Translational Medicine | 2010 |
Monoclonal Antibodies for Systemic Lupus Erythematosus (SLE)
C Ponticelli, G Moroni |
Pharmaceuticals (Basel, Switzerland) | 2010 |
Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity
D Yu, CG Vinuesa |
Cellular and Molecular Immunology | 2010 |
The role of B cell depleting therapy in graft versus host disease after allogeneic hematopoietic cell transplant
AM Alousi, J Uberti, V Ratanatharathorn |
Leukemia & Lymphoma | 2010 |
Treatment of systemic lupus erythematosus with epratuzumab
P Traczewski, L Rudnicka |
British Journal of Clinical Pharmacology | 2010 |
Differential B-lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1
JP Graham, KM Arcipowski, GA Bishop |
Immunological Reviews | 2010 |
Generation of Induced Pluripotent Stem Cells from Human Terminally Differentiated Circulating T Cells
T Seki, S Yuasa, M Oda, T Egashira, K Yae, D Kusumoto, H Nakata, S Tohyama, H Hashimoto, M Kodaira, Y Okada, H Seimiya, N Fusaki, M Hasegawa, K Fukuda |
Cell Stem Cell | 2010 |
Allospecific CD154+ B Cells Associate With Intestine Allograft Rejection in Children
C Ashokkumar, C Bentlejewski, Q Sun, BW Higgs, S Snyder, GV Mazariegos, K Abu-Elmagd, A Zeevi, R Sindhi |
Transplantation | 2010 |
Estrogen receptor signaling and its relationship to cytokines in systemic lupus erythematosus
E Kassi, P Moutsatsou |
Journal of biomedicine & biotechnology | 2010 |
B cells require "nurturing" by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus
A Choudhury, PL Cohen, RA Eisenberg |
Clinical Immunology | 2010 |
The DTH effector response and IL-2 are unaffected by cyclosporine A in autoimmune B6D2F1 mice
H MacLeod, DG Goodwin, C Damphousse, E Lonie, X Xu, M Collins, CL Nickerson-Nutter |
Cellular Immunology | 2010 |
Current Clinical Medicine
F Al-Ashkar |
Current Clinical Medicine | 2010 |
Defectos en la síntesis de cadena ζ en el linfocito T, generando señales intracelulares equivocadas, responsables de lupus eritematoso sistémico
HS M., F Rondón, JF Restrepo, R Pérez, A Iglesias |
Revista Colombiana de Reumatología | 2010 |
Gene Therapy for Autoimmune and Inflammatory Diseases
Y Chernajovsky, PD Robbins |
2010 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
The Multi-faceted Influences of Estrogen on Lymphocytes: Toward Novel Immuno-interventions Strategies for Autoimmunity Management
E Karpuzoglu, M Zouali |
Clinical Reviews in Allergy & Immunology | 2009 |
Serum levels of soluble CD40 ligand at flare and at remission in patients with systemic lupus erythematosus
M Urquizu-Padilla, E Balada, F Cortés, EH Pérez, M Vilardell-Tarrés, J Ordi-Ros |
The Journal of rheumatology | 2009 |
Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in systemic lupus erythematosus
SA Nicolaou, L Neumeier, K Takimoto, SM Lee, HJ Duncan, SK Kant, AB Mongey, AH Filipovich, L Conforti |
Cell Calcium | 2009 |
Regulatory T Cell (Treg) Subsets Return in Patients with Refractory Lupus following Stem Cell Transplantation, and TGF-β-Producing CD8 + Treg Cells Are Associated with Immunological Remission of Lupus
L Zhang, AM Bertucci, R Ramsey-Goldman, RK Burt, SK Datta |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
B-Cell-Directed Therapy for Inflammatory Skin Diseases
A Nagel, M Hertl, R Eming |
Journal of Investigative Dermatology | 2009 |
Peripheral B cell abnormalities in patients with systemic lupus erythematosus in quiescent phase: decreased memory B cells and membrane CD19 expression
AS Korganow, AM Knapp, H Nehme-Schuster, P Soulas-Sprauel, V Poindron, JL Pasquali, T Martin |
Journal of Autoimmunity | 2009 |
CD40 and autoimmunity: The dark side of a great activator
AL Peters, LL Stunz, GA Bishop |
Seminars in Immunology | 2009 |
Abnormal high-expression of CD154 on T lymphocytes of ankylosing spondylitis patients is down-regulated by etanercept treatment
Q Lin, Z Lin, J Gu, F Huang, T Li, Q Wei, Z Liao, S Cao, Y Jiang, J Huang |
Rheumatology International | 2009 |
Increased expression of CD154 and FAS in SLE patients’ lymphocytes
ME Manea, RB Mueller, D Dejica, A Sheriff, G Schett, M Herrmann, P Kern |
Rheumatology International | 2009 |
Increased expression of CD40 on bone marrow CD34+ hematopoietic progenitor cells in patients with systemic lupus erythematosus: Contribution to Fas-mediated apoptosis
K Pyrovolaki, I Mavroudi, P Sidiropoulos, AG Eliopoulos, DT Boumpas, HA Papadaki |
Arthritis & Rheumatism | 2009 |
Female predominance and X chromosome defects in autoimmune diseases
P Invernizzi, S Pasini, C Selmi, ME Gershwin, M Podda |
Journal of Autoimmunity | 2009 |
Post-transcriptional regulation in lymphocytes: the case of CD154
S Vavassori, LR Covey |
RNA biology | 2009 |
Cardiovascular risk assessment and treatment in systemic lupus erythematosus
JR Elliott, S Manzi |
Best Practice & Research Clinical Rheumatology | 2009 |
Treating lupus: from serendipity to sense, the rise of the new biologicals and other emerging therapies
E Sousa, D Isenberg |
Best Practice & Research Clinical Rheumatology | 2009 |
A review of the current use of rituximab in autoimmune diseases
HM Gürcan, DB Keskin, JN Stern, MA Nitzberg, H Shekhani, AR Ahmed |
International Immunopharmacology | 2009 |
Kelley's Textbook of Rheumatology
J Degroot, AM Zuurmond, PP Tak |
Kelley's Textbook of Rheumatology | 2009 |
BLyS Ligands and Receptors
MP Cancro |
2009 | |
CD44 high Memory CD8 T Cells Synergize with CpG DNA to Activate Dendritic Cell IL-12p70 Production
KL Wong, LF Tang, FC Lew, HS Wong, YL Chua, PA MacAry, DM Kemeny |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
Raised intrathecal levels of APRIL and BAFF in patients with systemic lupus erythematosus: relationship to neuropsychiatric symptoms
A George-Chandy, E Trysberg, K Eriksson |
Arthritis Research & Therapy | 2008 |
Systemic IFN‐α drives kidney nephritis in B6.Sle123mice
AM Fairhurst, A Mathian, JE Connolly, A Wang, HF Gray, TA George, CD Boudreaux, XJ Zhou, QZ Li, S Koutouzov, J Banchereau, EK Wakeland |
European Journal of Immunology | 2008 |
Not always the bad guys: B cells as regulators of autoimmune pathology
S Fillatreau, D Gray, SM Anderton |
Nature Reviews Immunology | 2008 |
Understanding Systemic Lupus Erythematosus Physiopathology in the Light of Primary Immunodeficiencies
M Carneiro-Sampaio, BL Liphaus, AA Jesus, CA Silva, JB Oliveira, MH Kiss |
Journal of Clinical Immunology | 2008 |
Autoimmunity in Hyper-IgM Syndrome
AA Jesus, AJ Duarte, JB Oliveira |
Journal of Clinical Immunology | 2008 |
X chromosome in autoimmune diseases
P Invernizzi, S Pasini, M Podda |
Expert Review of Clinical Immunology | 2008 |
CD40L-expressing CD8 T cells prime CD8α+DC for IL-12p70 production
KL Wong, FC Lew, PA MacAry, DM Kemeny |
European Journal of Immunology | 2008 |
How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype
JC Crispín, VC Kyttaris, YT Juang, GC Tsokos |
Trends in Immunology | 2008 |
Successful Treatment of Neuropsychiatric Syndrome with Rituximab in a Patient with Systemic Lupus Erythematosus and Dermatomyositis Overlap Syndrome
SG Lee, B Yoo, KM Kim, HO Choi, JS Oh, SS Nah, YG Kim, CK Lee |
The Journal of the Korean Rheumatism Association | 2008 |
The Relationship Between the Antiphospholipid Syndrome and Heparin-Induced Thrombocytopenia
DA Hoppensteadt, JM Walenga |
Hematology/Oncology Clinics of North America | 2008 |
Rituximab-induced B cell depletion in autoimmune diseases: Potential effects on T cells
SN Liossis, PP Sfikakis |
Clinical Immunology | 2008 |
The X in sex: how autoimmune diseases revolve around sex chromosomes
C Selmi |
Best Practice & Research Clinical Rheumatology | 2008 |
Lupus systémique : les traitements du futur
Z Amoura, J Haroche, JC Piette |
La Revue de Médecine Interne | 2008 |
CTL-Promoting Effects of CD40 Stimulation Outweigh B Cell-Stimulatory Effects Resulting in B Cell Elimination and Disease Improvement in a Murine Model of Lupus
R Puliaev, I Puliaeva, LA Welniak, AE Ryan, M Haas, WJ Murphy, CS Via |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Splenic Phagocytes Promote Responses to Nucleosomes in (NZB × NZW) F 1 Mice
A Okamoto, K Fujio, N van Rooijen, NH Tsuno, K Takahashi, H Tsurui, S Hirose, KB Elkon, K Yamamoto |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Demethylation of CD40LG on the inactive X in T cells from women with lupus
Q Lu, A Wu, L Tesmer, D Ray, N Yousif, B Richardson |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration
T Harada, V Kyttaris, Y Li, YT Juang, Y Wang, GC Tsokos |
Autoimmunity | 2007 |
Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis
PP Sfikakis, VL Souliotis, KG Fragiadaki, HM Moutsopoulos, JN Boletis, AN Theofilopoulos |
Clinical Immunology | 2007 |
Abnormalities in lymphocyte telomerase activity and telomere length in systemic lupus erythematosus
D KUROSAKA |
Japanese Journal of Clinical Immunology | 2007 |
The role of preventive cardiology in systemic lupus erythematosus
JR Elliott, S Manzi, D Edmundowicz |
Current Rheumatology Reports | 2007 |
Hyperexpression of cyclooxygenase 2 in the lupus immune system and effect of cyclooxygenase 2 inhibitor diet therapy in a murine model of systemic lupus erythematosus
L Zhang, AM Bertucci, KA Smith, L Xu, SK Datta |
Arthritis & Rheumatism | 2007 |
Physiopathologie du lupus érythémateux systémique
P Blanco, JL Pellegrin, JF Moreau, JF Viallard |
La Presse Médicale | 2007 |
Contemporary Targeted Therapies in Rheumatology
P Lent, W Berg |
Contemporary Targeted Therapies in Rheumatology | 2007 |
Increased Levels of NF-ATc2 Differentially Regulate CD154 and IL-2 Genes in T Cells from Patients with Systemic Lupus Erythematosus
VC Kyttaris, Y Wang, YT Juang, A Weinstein, GC Tsokos |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
The role of preventive cardiology in systemic lupus erythematosus.
Elliott JR, Manzi S, Edmundowicz D |
Current Rheumatology Reports | 2007 |
Development of Autoimmunity in IL-14α-Transgenic Mice
L Shen, C Zhang, T Wang, S Brooks, RJ Ford, YC Lin-Lee, A Kasianowicz, V Kumar, L Martin, P Liang, J Cowell, JL Ambrus |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
Modification of accessory molecule signaling
MK Crow |
Springer Seminars in Immunopathology | 2006 |
Costimulatory molecules as immunotherapeutic targets in systemic lupus erythematosus
J Foell, RS Mittler |
Springer Seminars in Immunopathology | 2006 |
Systems biology in systemic lupus erythematosus: Integrating genes, biology and immune function
VC Kyttaris, S Krishnan, GC Tsokos |
Autoimmunity | 2006 |
Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus
L Colonna, JA Dinnall, DK Shivers, L Frisoni, R Caricchio, S Gallucci |
Arthritis Research & Therapy | 2006 |
FK506 controls CD40L-induced systemic autoimmunity in mice
K Loser, S Balkow, T Higuchi, J Apelt, A Kuhn, TA Luger, S Beissert |
Journal of Investigative Dermatology | 2006 |
Autoimmunity in systemic lupus erythematosus: Integrating genes and biology☆
S Krishnan, B Chowdhury, GC Tsokos |
Seminars in Immunology | 2006 |
The mechanisms of antinuclear antibody production and its pathogenicity in systemic autoimmune diseases
T FUJII |
Japanese Journal of Clinical Immunology | 2006 |
B cell depletion therapy in systemic lupus erythematosus: Effect on autoantibody and antimicrobial antibody profiles
G Cambridge, MJ Leandro, M Teodorescu, J Manson, A Rahman, DA Isenberg, JC Edwards |
Arthritis & Rheumatism | 2006 |
B-cell abnormality and systemic lupus erythematosus
T TSUBATA |
APLAR Journal of Rheumatology | 2006 |
A distinct inflammatory gene expression profile in patients with psoriatic arthritis
AK Stoeckman, EC Baechler, WA Ortmann, TW Behrens, CJ Michet, EJ Peterson |
Genes and Immunity | 2006 |
Update on the treatment of lupus nephritis
M Waldman, GB Appel |
Kidney International | 2006 |
Elevated levels of soluble CD40 ligand (sCD40L) in serum of patients with systemic autoimmune diseases
A Goules, AG Tzioufas, MN Manousakis, KA Kirou, MK Crow, JG Routsias |
Journal of Autoimmunity | 2006 |
BAFF, APRIL and human B cell disorders
SG Tangye, VL Bryant, AK Cuss, KL Good |
Seminars in Immunology | 2006 |
Cell-surface and cytokine biomarkers in autoimmune and inflammatory diseases
RM O’Hara, SE Benoit, CJ Groves, M Collins |
Drug Discovery Today | 2006 |
Premature atherosclerotic disease in systemic lupus erythematosus — role of inflammatory mechanisms
EY Rhew, R Ramsey-Goldman |
Autoimmunity Reviews | 2006 |
Intra-Vascular Ultrasound Findings of Diffuse Coronary Atherosclerotic Change in Systemic Lupus Erythematosus With Secondary Antiphospholipid Syndrome
Y Ikeda, S Yagi, H Yamaguchi, M Fujimura, S Hashizume, K Aihara, M Akaike, H Azuma, T Matsumoto |
Circulation Journal | 2006 |
T-cell-directed therapy in systemic lupus erythematosus
RW Hoffman |
Future Rheumatology | 2006 |
Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival
R Lesley, LM Kelly, Y Xu, JG Cyster |
Proceedings of the National Academy of Sciences | 2006 |
Systemic Lupus Erythematosus
M Petri |
JCR: Journal of Clinical Rheumatology | 2006 |
The Autoimmune Diseases
I Kang, J Craft |
The Autoimmune Diseases | 2006 |
Systemic lupus erythematosus: From disease pathogenesis to therapy
CG Katsiari, GC Tsokos |
Drug Discovery Today: Disease Mechanisms | 2006 |
Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease: Is CD4 T cell receptor ligation needed?
W Li, WR Green |
Virology | 2006 |
Estrogen does not regulate CD154 mRNA stability in systemic lupus erythematosus T cells
X Li, V Rider, BF Kimler, NI Abdou |
Lupus | 2006 |
Inflammation and the pathogenesis of atherosclerosis in systemic lupus erythematosus
M McMahon, J Grossman, W Chen, BH Hahn |
Lupus | 2006 |
Mycophenolate mofetil and cardiovascular disease
G Hughes, H Phillips |
Lupus | 2006 |
Increased Levels of Soluble CD40L in African Tick Bite Fever: Possible Involvement of TLRs in the Pathogenic Interaction between Rickettsia africae , Endothelial Cells, and Platelets
JK Damås, M Jensenius, T Ueland, K Otterdal, A Yndestad, SS Frøland, JM Rolain, B Myrvang, D Raoult, P Aukrust |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
Stability and Translation of TCR ζ mRNA Are Regulated by the Adenosine-Uridine-Rich Elements in Splice-Deleted 3′ Untranslated Region of ζ-Chain
B Chowdhury, S Krishnan, CG Tsokos, JW Robertson, CU Fisher, MP Nambiar, GC Tsokos |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
SLE serum IgG increase CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
Yuang-Taung Juang, Ying Wang, Elena E. Solomou, Yansong Li, Christian Mawrin, Klaus Tenbrock Vasileios C. Kyttaris, George C. Tsokos |
Journal of Clinical Investigation | 2005 |
IFN-α Induces Early Lethal Lupus in Preautoimmune (New Zealand Black × New Zealand White)F 1 but Not in BALB/c Mice
A Mathian, A Weinberg, M Gallegos, J Banchereau, S Koutouzov |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigens
SK Datta, L Zhang, L Xu |
Journal of Molecular Medicine | 2005 |
Naive CD4 + T Cells from Lupus-Prone Fas-Intact MRL Mice Display TCR-Mediated Hyperproliferation Due to Intrinsic Threshold Defects in Activation
CE Zielinski, SN Jacob, F Bouzahzah, BE Ehrlich, J Craft |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
Autoimmune mechanisms in children with systemic lupus erythematosus
D Stichweh, V Pascual |
Current Rheumatology Reports | 2005 |
New therapies for systemic lupus erythematosus
F Goldblatt, DA Isenberg |
Clinical & Experimental Immunology | 2005 |
Monoclonal antibodies and fusion proteins in medicine
SN Liossis, GC Tsokos |
Journal of Allergy and Clinical Immunology | 2005 |
Cardiovascular disease in systemic lupus erythematosus: has the time for action come?
SI van Leuven, JJ Kastelein, MR Hayden, D dʼCruz, GR Hughes, ES Stroes |
Current Opinion in Lipidology | 2005 |
Anti-CD20 therapy in systemic lupus erythematosus: A step closer to the clinic
GJ Silverman |
Arthritis & Rheumatism | 2005 |
Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: An open-label trial
PP Sfikakis, JN Boletis, S Lionaki, V Vigklis, KG Fragiadaki, A Iniotaki, HM Moutsopoulos |
Arthritis & Rheumatism | 2005 |
Rituximab anti-B-cell therapy in systemic lupus erythematosus: pointing to the future
PP Sfikakis, JN Boletis, GC Tsokos |
Current Opinion in Rheumatology | 2005 |
Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer
A Nakamura, K Akiyama, T Takai |
Expert Opinion on Therapeutic Targets | 2005 |
Study of Plasma Levels of Soluble CD40 Ligand in Systemic Lupus Erythematosus Patients Who Have Undergone Plasmapheresis
K Kimura, H Tsuda, Y Kwangseok, N Tamura, Y Kanai, S Kobayashi |
Therapeutic Apheresis and Dialysis | 2005 |
Spotlight on the role of hormonal factors in the emergence of autoreactive B-lymphocytes
E Peeva, M Zouali |
Immunology Letters | 2005 |
Effects of sex hormones on costimulatory molecule expression in multiple sclerosis
CM Pelfrey, IR Moldovan, AC Cotleur, N Zamor, RA Rudick |
Journal of Neuroimmunology | 2005 |
Rituximab anti-B-cell therapy in systemic lupus erythematosus: pointing to the future:
PP Sfikakis, JN Boletis, GC Tsokos |
Current Opinion in Rheumatology | 2005 |
B cell abnormality and autoimmune disorders
T Tsubata |
Autoimmunity | 2005 |
Increased prevalence of activated CD70+CD4+ T cells in the periphery of patients with systemic lupus erythematosus
BK Han, AM White, KH Dao, DR Karp, EK Wakeland, LS Davis |
Lupus | 2005 |
CD40 Ligand Expression Correlates with Resolution of Peritonitis and Mononuclear Cell Recruitment
A Glik, J Mazar, B Rogachev, M Zlotnik, A Douvdevani |
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis | 2005 |
Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
Juang YT, Wang Y, Solomou EE, Li Y, Mawrin C, Tenbrock K, Kyttaris VC, Tsokos GC |
Journal of Clinical Investigation | 2005 |
Ectopic CD40 ligand expression on B cells triggers intestinal inflammation
T Kawamura, T Kanai, T Dohi, K Uraushihara, T Totsuka, R Iiyama, C Taneda, M Yamazaki, T Nakamura, T Higuchi, Y Aiba, T Tsubata, M Watanabe |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Nucleosome-specific regulatory T cells engineered by triple gene transfer suppress a systemic autoimmune disease
K Fujio, A Okamoto, H Tahara, M Abe, Y Jiang, T Kitamura, S Hirose, K Yamamoto |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus
JH Anolik, J Barnard, A Cappione, AE Pugh-Bernard, RE Felgar, RJ Looney, I Sanz |
Arthritis & Rheumatism | 2004 |
Targeting CD40L: a promising therapeutic approach
D Daoussis, AP Andonopoulos, SN Liossis |
Clinical and diagnostic laboratory immunology | 2004 |
Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors
K Oelke, Q Lu, D Richardson, A Wu, C Deng, S Hanash, B Richardson |
Arthritis & Rheumatism | 2004 |
DECREASED T CELL ERK PATHWAY SIGNALING MAY CONTRIBUTE TO THE DEVELOPMENT OF LUPUS THROUGH EFFECTS ON DNA METHYLATION AND GENE EXPRESSION
K Oelke, B Richardson |
International Reviews of Immunology | 2004 |
A new CD21low B cell population in the peripheral blood of patients with SLE
C Wehr, H Eibel, M Masilamani, H Illges, M Schlesier, HH Peter, K Warnatz |
Clinical Immunology | 2004 |
Involvement of CD40-CD154 interaction in immunopathogenesis of collagen diseases and its application to a novel therapeutic strategy
M HARIGAI |
Japanese Journal of Clinical Immunology | 2004 |
Update on pediatric systemic lupus erythematosus
D Stichweh, E Arce, V Pascual |
Current Opinion in Rheumatology | 2004 |
Recent advances in vascular inflammation: C-reactive protein and other inflammatory biomarkers
K Maksimowicz-McKinnon, DL Bhatt, LH Calabrese |
Current Opinion in Rheumatology | 2004 |
IL-10 production in B cells is confined to CD154+ cells in patients with systemic lupus erythematosus
A Díaz-Alderete, JC Crispin, MI Vargas-Rojas, J Alcocer-Varela |
Journal of Autoimmunity | 2004 |
Human immunodeficiency virus (HIV) type 1 Vpu induces the expression of CD40 in endothelial cells and regulates HIV-induced adhesion of B-lymphoma cells
WW Henderson, R Ruhl, P Lewis, M Bentley, JA Nelson, AV Moses |
Journal of virology | 2004 |
The dinucleotide repeat polymorphism in the 3'UTR of the CD154 gene has a functional role on protein expression and is associated with systemic lupus erythematosus
MJ Citores, I Rua-Figueroa, C Rodriguez-Gallego, A Durántez, MI García-Laorden, C Rodríguez-Lozano, JC Rodríguez-Pérez, JA Vargas, P Pérez-Aciego |
Annals of the rheumatic diseases | 2004 |
Costimulatory molecules and T-cell–B-cell interactions
MK Crow |
Rheumatic Disease Clinics of North America | 2004 |
Regulation of immune function by calorie restriction and cyclophosphamide treatment in lupus-prone NZB/NZW F1 mice
D Sun, A Krishnan, J Su, R Lawrence, K Zaman, G Fernandes |
Cellular Immunology | 2004 |
Down-regulation of CD40 and CD80 on B cells in patients with life-threatening systemic lupus erythematosus after successful treatment with rituximab
M Tokunaga, K Fujii, K Saito, S Nakayamada, S Tsujimura, M Nawata, Y Tanaka |
Rheumatology | 2004 |
Biomarkers in systemic lupus erythematosus: II. Markers of disease activity
GG Illei, E Tackey, L Lapteva, PE Lipsky |
Arthritis & Rheumatism | 2004 |
Update on pediatric systemic lupus erythematosus:
D Stichweh, E Arce, V Pascual |
Current Opinion in Rheumatology | 2004 |
Costimulation Blockade in the Treatment of Rheumatic Diseases:
SN Liossis, PP Sfikakis |
BioDrugs | 2004 |
Principles of Gender-Specific Medicine
G Supinski, LA Callahan |
Principles of Gender-Specific Medicine | 2004 |
Pathogenesis of SLE: implications for rational therapy
G Franchin, E Peeva, B Diamond |
Drug Discovery Today: Disease Mechanisms | 2004 |
Autoimmunity through Cytokine-Induced Dendritic Cell Activation
J Banchereau, V Pascual, AK Palucka |
Immunity | 2004 |
Ongoing Immunoglobulin Class Switch DNA Recombination in Lupus B Cells: Analysis of Switch Regulatory Regions
S Liu, A Cerutti, P Casali, MK Crow |
Autoimmunity | 2004 |
Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients
PI Sidiropoulos, DT Boumpas |
Lupus | 2004 |
Re-establishment of tolerance: the prospect of developing specific treatment for human lupus
CG Katsiari, GC Tsokos |
Lupus | 2004 |
The role of CD40 ligand in systemic lupus erythematosus
J Yazdany, J Davis |
Lupus | 2004 |
Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus
AM Jacobi, M Odendahl, K Reiter, A Bruns, GR Burmester, A Radbruch, G Valet, PE Lipsky, T Dörner |
Arthritis & Rheumatism | 2003 |
The naive B cell repertoire predisposes to antigen-induced systemic lupus erythematosus
C Wang, M Khalil, J Ravetch, B Diamond |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
Effects of anti-CD154 treatment on B cells in murine systemic lupus erythematosus
X Wang, W Huang, LE Schiffer, M Mihara, A Akkerman, K Hiromatsu, A Davidson |
Arthritis & Rheumatism | 2003 |
Therapeutic CD154 antibody for lupus: promise for the future?
G Kelsoe |
Journal of Clinical Investigation | 2003 |
B cell depletion therapy in systemic lupus erythematosus
J Anolik, I Sanz, RJ Looney |
Current Rheumatology Reports | 2003 |
Major Peptide Autoepitopes for Nucleosome-Centered T and B Cell Interaction in Human and Murine Lupus
SK Datta |
Annals of the New York Academy of Sciences | 2003 |
Monocyte response to Th1 stimulation and effector function toward human mesangial cells are not impaired in patients with lupus nephritis
T Kuroiwa, R Schlimgen, GG Illei, DT Boumpas |
Clinical Immunology | 2003 |
The CD40–CD154 interaction in B cell–T cell liaisons
GA Bishop, BS Hostager |
Cytokine & Growth Factor Reviews | 2003 |
Differential regulation of Th1 responses and CD154 expression in human CD4+ T cells by IFN-alpha
H Shibuya, T Nagai, A Ishii, K Yamamoto, S Hirohata |
Clinical & Experimental Immunology | 2003 |
A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
DT Boumpas, R Furie, S Manzi, GG Illei, DJ Wallace, JE Balow, A Vaishnaw |
Arthritis & Rheumatism | 2003 |
Update on vascular disease in systemic lupus erythematosus
AH Kao, JM Sabatine, S Manzi |
Current Opinion in Rheumatology | 2003 |
CD154 expression and mRNA stability of activated CD4-positive T cells in patients with systemic lupus erythematosus
M Takaya, N Tamura, K Kato, S Kobayashi, K Haruta, M Tajima, M Hara, KS Yang, H Tsuda, H Hashimoto |
Modern Rheumatology | 2003 |
Immunopathology and the gene therapy of lupus
RA Mageed, GJ Prud'homme |
Gene Therapy | 2003 |
Cytokines and Chemokines in Autoimmune Disease
P Santamaria |
2003 | |
Lack of the Transcriptional Coactivator OBF-1 Prevents the Development of Systemic Lupus Erythematosus-Like Phenotypes in Aiolos Mutant Mice
J Sun, G Matthias, MJ Mihatsch, K Georgopoulos, P Matthias |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
CD4 + T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo
F Bouzahzah, S Jung, J Craft |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
CD40, but Not CD154, Expression on B Cells Is Necessary for Optimal Primary B Cell Responses
BO Lee, J Moyron-Quiroz, J Rangel-Moreno, KL Kusser, L Hartson, F Sprague, FE Lund, TD Randall |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
CD154 Transcriptional Regulation in Primary Human CD4 T Cells
RQ Cron |
Immunologic Research | 2003 |
The effect of anti-CD40 ligand antibody on B cells in human systemic lupus erythematosus
W Huang, J Sinha, J Newman, B Reddy, L Budhai, R Furie, A Vaishnaw, A Davidson |
Arthritis & Rheumatism | 2002 |
New therapies in systemic lupus erythematosus
MA Solsky, DJ Wallace |
Best Practice & Research Clinical Rheumatology | 2002 |
Suppressor of Cytokine Signaling 1 Inhibits Cytokine Induction of CD40 Expression in Macrophages
DR Wesemann, Y Dong, GM OKeefe, VT Nguyen, EN Benveniste |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Novel therapeutic agents for systemic lupus erythematosus
BD Gescuk, JC Davis |
Current Opinion in Rheumatology | 2002 |
Malignancy and systemic lupus erythematosus
S Bernatsky, A Clarke, R Ramsey-Goldman |
Current Rheumatology Reports | 2002 |
CD154-CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosus
AC Grammer, PE Lipsky |
Arthritis & Rheumatism | 2002 |
Aberrant Expression of the Costimulatory Molecule CD40 Ligand on Monocytes from Patients with Systemic Lupus Erythematosus
CG Katsiari, SN Liossis, VL Souliotis, AM Dimopoulos, MN Manoussakis, PP Sfikakis |
Clinical Immunology | 2002 |
B Cell Stimulatory Effects of α-Enolase That Is Differentially Expressed in NZB Mouse B Cells
JS Babu, T Sun, L Xu, SK Datta |
Clinical Immunology | 2002 |
Isolation and Functional Analysis of Autoreactive T cells from BXSB Mice with Murine Lupus
SH Han, B Li, YT Chen, XM Gao |
Journal of Autoimmunity | 2002 |
The transmembrane form of TNF-alpha drives autoantibody production in the absence of CD154: studies using MRL/Mp-Fas(lpr) mice
T Fujii, M Okada, T Mimori, J Craft |
Clinical & Experimental Immunology | 2002 |
Abnormal T cell signal transduction in systemic lupus erythematosus
GM Kammer, A Perl, BC Richardson, GC Tsokos |
Arthritis & Rheumatism | 2002 |
Lupus eritematoso sistémico y enfermedad cardiovascular
S Jiménez, J Font, M Ingelmo |
Medicina Clínica | 2002 |
CD40L overexpression on T cells and monocytes from patients with systemic lupus erythematosus is resistant to calcineurin inhibition
CG Katsiari, SN Liossis, AM Dimopoulos, DV Charalambopoulos, M Mavrikakis, PP Sfikakis |
Lupus | 2002 |
Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosus
HJ Girschick, AC Grammer, T Nanki, E Vazquez, PE Lipsky |
Arthritis & Rheumatism | 2002 |
Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: A randomized, double-blind, placebo-controlled trial
KC Kalunian, JC Davis, JT Merrill, MC Totoritis, D Wofsy |
Arthritis & Rheumatism | 2002 |
CD154 is expressed during treatment with calcineurin inhibitors after organ transplantation:
MM van Rijen, ML Kuijf, HJ Metselaar, HW Tilanus, GJ Bouma, RA de Weger, M Jonker, J Kwekkeboom |
Transplantation | 2002 |
Cutting Edge: Ectopic Expression of CD40 Ligand on B Cells Induces Lupus-Like Autoimmune Disease
T Higuchi, Y Aiba, T Nomura, J Matsuda, K Mochida, M Suzuki, H Kikutani, T Honjo, K Nishioka, T Tsubata |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
CD40, CD154, Bax and Bcl -2 Expression in Sjögren's Syndrome Salivary Glands: a Putative Anti-Apoptotic Role During its Effector Phases: CD40, CD154, Bax and Bcl-2 in Sjögren's Syndrome
M Ohlsson, P Szodoray, LL Loro, AC Johannessen, R Jonsson |
Scandinavian Journal of Immunology | 2002 |
Does CD40 Ligation Induce B Cell Negative Selection?
J Martínez-Barnetche, V Madrid-Marina, RA Flavell, J Moreno |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Long-term anti-CD154 dosing in nephritic mice is required to maintain survival and inhibit mediators of renal fibrosis
SL Kalled, AH Cutler, JL Ferrant |
Lupus | 2001 |
Crossreactivity of Human Anti-dsDNA Antibodies to Phosphorylcholine: Clues to Their Origin
A Sharma, DA Isenberg, B Diamond |
Journal of Autoimmunity | 2001 |
Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus
E Arce, DG Jackson, MA Gill, LB Bennett, J Banchereau, V Pascual |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Regulation of CD40 ligand expression in systemic lupus erythematosus
MK Crow, KA Kirou |
Current Opinion in Rheumatology | 2001 |
Novel approaches in the treatment of lupus nephritis
L Czirják, GG Illei |
Expert Opinion on Investigational Drugs | 2001 |
Expression of CD40 and CD40 Ligand among Cell Populations within Rheumatoid Synovial Compartment
MF Liu, SC Chao, CR Wang, HY Lei |
Autoimmunity | 2001 |
ADVANCES IN THETREATMENT OFLUPUSNEPHRITIS
R Zimmerman, J Radhakrishnan, A Valeri, G Appel |
Annual Review of Medicine | 2001 |
Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells
N Mishra, DR Brown, IM Olorenshaw, GM Kammer |
Proceedings of the National Academy of Sciences | 2001 |
Multiple cytokines sharing the common receptor gamma chain can induce CD154/CD40 ligand expression by human CD4+ T lymphocytes via a cyclosporin A-resistant pathway
JD Fayen |
Immunology | 2001 |
NF-kappaB is involved in the regulation of CD154 (CD40 ligand) expression in primary human T cells
M Srahna, JE Remacle, K Annamalai, S Pype, D Huylebroeck, MA Boogaerts, P Vandenberghe |
Clinical & Experimental Immunology | 2001 |
POTENTIAL BIOLOGIC AGENTS FOR TREATING RHEUMATOID ARTHRITIS
LW Moreland |
Rheumatic Disease Clinics of North America | 2001 |
Functional properties of lymphocytes in idiopathic thrombocytopenic purpura
NP Webber, JO Mascarenhas, MK Crow, J Bussel, EJ Schattner |
Human Immunology | 2001 |
Analysis of the CD40/CD40L role in the sustenance of alloreactive antibody production
AS Shoker, ZR Lun, R Choudry, A Saxena |
Transplant Immunology | 2001 |
Atherosclerosis and Autoimmunity
EC Lau |
Atherosclerosis and Autoimmunity | 2001 |
The Cytokine FactsBook and Webfacts
KA Fitzgerald, LA O'Neill, AJ Gearing, RE Callard |
The Cytokine FactsBook and Webfacts | 2001 |
Telomeres, Telomerase, and Lupus: The Long and Short of It
V Rus, CS Via |
Clinical Immunology | 2001 |
T cell activation following infection of primary follicle center lymphoma B cells with adenovirus encoding CD154
MJ Cantwell, WG Wierda, IS Lossos, R Levy, TJ Kipps |
Leukemia | 2001 |
Apoptosis and Altered Dendritic Cell Homeostasis in Lupus Nephritis Are Limited by Anti-CD154 Treatment
SL Kalled, AH Cutler, LC Burkly |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Evaluation of chronic urticaria in patients with Hashimoto thyroiditis
A A Kandeel, M Zeid, T Helm, M A Lillie, E Donahue, J L Ambrus Jr |
Journal of Clinical Immunology | 2001 |
TGF-beta1 null mutation leads to CD154 upregulated expression in affected tissues
T Nakabayashi, K M Sakata, A Sakata, L Kong, C A Lau, J J Letterio, N Vela-Roch, N Talal, H Dang |
Inflammation | 2001 |
B Cells from Autoimmune BXSB Mice are Hyporesponsive to Signals Provided by CD4+T Cells
SJ Blossom, KM Gilbert |
Immunological Investigations | 2000 |
T cells in the pathogenesis of systemic lupus erythematosus: Potential roles of CD154-CD40 interactions and costimulatory molecules
MJ Yellin, U Thienel |
Current Rheumatology Reports | 2000 |
Clinical trials in systemic lupus erythematosus
JP Buyon |
Current Rheumatology Reports | 2000 |
Dehydroepiandrosterone and biologics in the treatment of systemic lupus erythematosus
R Furie |
Current Rheumatology Reports | 2000 |
MHC Class II Associations with Autoantibody and T cell Immune Responses to the Scleroderma Autoantigen Topoisomerase I
AL Rands, J Whyte, B Cox, ND Hall, NJ McHugh |
Journal of Autoimmunity | 2000 |
Immune cell signaling in lupus
GC Tsokos, HK Wong, EJ Enyedy, MP Nambiar |
Current Opinion in Rheumatology | 2000 |
Progress in the treatment of proliferative lupus nephritis
JE Balow, HA Austin |
Current Opinion in Nephrology and Hypertension | 2000 |
CD154 polymorphism in Spanish populations. Differences in the allelic distribution between Canary Islanders and Peninsulars
MJ Citores, P Perez-Aciego, C Rodriguez-Gallego, B Contreras-Martin, I Garcia-Laorden, A Durantez |
European Journal of Immunogenetics | 2000 |
Elevated CD40 Ligand Expressing Blood T-Cell Levels in Multiple Sclerosis Are Reversed by Interferon-Beta Treatment
Teleshova, Bao, Kivisakk, Ozenci, Mustafa, Link |
Scandinavian Journal of Immunology | 2000 |
An increased number of CD40-high monocytes in patients with Crohn's disease
N Sawada-Hase, T Kiyohara, J Miyagawa, H Ueyama, H Nishibayashi, Y Murayama, T Kashihara, M Nakahara, Y Miyazaki, S Kanayama, R Nezu, Y Shinomura, Y Matsuzawa |
The American Journal of Gastroenterology | 2000 |
CD40 Ligand in CLL Pathogenesis and Therapy
EJ Schattner |
Leukemia & Lymphoma | 2000 |
Increased expression of CD40 ligand (CD154) on CD4+ T cells as a marker of disease activity in rheumatoid arthritis
B Berner, G Wolf, KM Hummel, GA Müller, MA Reuss-Borst |
Annals of the rheumatic diseases | 2000 |
Fortifying B cells with CD154: an engaging tale of many hues
J Gordon, JD Pound |
Immunology | 2000 |
Inflammation-mediated rheumatic diseases and atherosclerosis
S Manzi, MC Wasko |
Annals of the rheumatic diseases | 2000 |
Cytokines and systemic lupus erythematosus
GS Dean, J Tyrrell-Price, E Crawley, DA Isenberg |
Annals of the rheumatic diseases | 2000 |
GENETICS OF SYSTEMIC LUPUS ERYTHEMATOSUS
KE Sullivan |
Rheumatic Disease Clinics of North America | 2000 |
Transcriptional Activity of the Distal CD40 Ligand Promoter
FM Lobo, S Xu, C Lee, RL Fuleihan |
Biochemical and Biophysical Research Communications | 2000 |
Molecular aberrations in human systemic lupus erythematosus
GC Tsokos, GM Kammer |
Molecular Medicine Today | 2000 |
Women and Health
R Ramsey-Goldman, S Manzi |
Women and Health | 2000 |
Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity:
R Cavaleiro, AE Sousa, A Loureiro, RM Victorino |
AIDS | 2000 |
Systemic lupus erythematosus—messages from experimental models
ML Stoll, J Gavalchin |
Rheumatology (Oxford, England) | 2000 |
Intravenous cyclophosphamide in SLE
E Toubi, A Kessel |
Lupus | 2000 |
Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice
T Yoshida, T Higuchi, H Hagiyama, A Strasser, K Nishioka, T Tsubata |
International Immunology | 2000 |
Effect of intravenous cyclophosphamide in systemic lupus erythematosus: relation to lymphocyte subsets and activation markers
H Amano, S Morimoto, H Kaneko, Y Tokano, Y Takasaki, H Hashimoto |
Lupus | 2000 |
Positive selection for autoimmunity
SK Datta |
Nature Medicine | 2000 |
HEIGHTENED CD40 LIGAND GENE EXPRESSION IN PERIPHERAL CD4+ T CELLS FROM PATIENTS WITH KIDNEY ALLOGRAFT REJECTION:
A Shoker, D George, H Yang, M Baltzan |
Transplantation | 2000 |
Human Double-Negative T Cells in Systemic Lupus Erythematosus Provide Help for IgG and Are Restricted by CD1c
PA Sieling, SA Porcelli, BT Duong, F Spada, BR Bloom, B Diamond, BH Hahn |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Regulatory Defects in Cbl and Mitogen-Activated Protein Kinase (Extracellular Signal-Related Kinase) Pathways Cause Persistent Hyperexpression of CD40 Ligand in Human Lupus T Cells
Y Yi, M McNerney, SK Datta |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
CD4 + T Lymphocytes with Constitutive CD40 Ligand in Preautoimmune (NZB × NZW)F 1 Lupus-Prone Mice: Phenotype and Possible Role in Autoreactivity
H Lettesjö, GP Burd, RA Mageed |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Sustained Expression of CD154 (CD40L) and Proinflammatory Cytokine Production by Alloantigen-Stimulated Umbilical Cord Blood T Cells
NC Matthews, M Wadhwa, C Bird, FE Borras, CV Navarrete |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Strong and Selective Glomerular Localization of CD134 Ligand and TNF Receptor-1 in Proliferative Lupus Nephritis
J Aten, A Roos, N Claessen, EJ Schilder-Tol, IJ Berge, JJ Weening |
Journal of the American Society of Nephrology : JASN | 2000 |
Prevention of Experimental Colitis in SCID Mice Reconstituted with CD45RB high CD4 + T Cells by Blocking the CD40-CD154 Interactions
Z Liu, K Geboes, S Colpaert, L Overbergh, C Mathieu, H Heremans, M de Boer, L Boon, G DHaens, P Rutgeerts, JL Ceuppens |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Immune aberrations in B and T lymphocytes derived from chronic urticaria patients
E Toubi, A Adir-Shani, A Kessel, Z Shmuel, E Sabo, H Hacham |
Journal of Clinical Immunology | 2000 |
Major peptide autoepitopes for nucleosome-specific T cells of human lupus
L Lu, A Kaliyaperumal, DT Boumpas, SK Datta |
Journal of Clinical Investigation | 1999 |
The soluble CD40 ligand sCD154 in systemic lupus erythematosus
K Kato, E Santana-Sahagún, LZ Rassenti, MH Weisman, N Tamura, S Kobayashi, H Hashimoto, TJ Kipps |
Journal of Clinical Investigation | 1999 |
Autoreactive T cells in murine lupus
J Craft, S Peng, T Fujii, M Okada, S Fatenejad |
Immunologic Research | 1999 |
Synergistic effect of interleukin-1 and CD40L on the activation of human renal tubular epithelial cells
CV Kooten, XV der Linde, AM Woltman, LA van Es, MR Daha |
Kidney International | 1999 |
Vasculitides secondary to systemic diseases
AD Rosso, S Generini, A Pignone, M Matucci-Cerinic |
Clinics in Dermatology | 1999 |
Apoptosis of Mature B Cells
T Tsubata |
International Reviews of Immunology | 1999 |
Antibody production in autoimmune BXSB mice. I. CD40L-expressing B cells need fewer signals for polyclonal antibody synthesis
S Blossom, KM Gilbert |
Clinical & Experimental Immunology | 1999 |
Soluble CD40 in the serum of healthy donors, patients with chronic renal failure, haemodialysis and chronic ambulatory peritoneal dialysis (CAPD) patients
RF Schwabe, H Engelmann, S Hess, H Fricke |
Clinical & Experimental Immunology | 1999 |
Early reduction of the over-expression of CD40L, OX40 and Fas on T cells in HIV-1 infection during triple anti-retroviral therapy: possible implications for lymphocyte traffic and functional recovery
AE Sousa, AF Chaves, M Doroana, F Antunes, RM Victorino |
Clinical & Experimental Immunology | 1999 |
Autoreactive T cells in murine lupus: Origins and Roles in Autoantibody Production
J Craft, S Peng, T Fujii, M Okada, S Fatenejad |
Immunologic Research | 1999 |
Immune cell signaling defects in lupus: activation, anergy and death
GC Tsokos, SN Liossis |
Immunology Today | 1999 |
Regulation of CD40L Expression by Cyclic AMP: Contrasting Proinflammatory and Inhibitory Actions
DG Wingett, K Forcier, CP Nielson |
Cellular Immunology | 1999 |
High prevalence of T cell type I protein kinase a deficiency in systemic lupus erythematosus
GM Kammer |
Arthritis & Rheumatism | 1999 |
Responsiveness of peripheral blood B cells to recombinant CD40 ligand in patients with systemic lupus erythematosus
M Harigai, M Hara, C Fukasawa, S Nakazawa, Y Kawaguchi, N Kamatani, S Kashiwazaki |
Lupus | 1999 |
PRODUCTION OF HUMAN ALLOREACTIVE ANTIBODIES BY UREMIC SENSITIZED LYMPHOCYTES ENGRAFTED IN SEVERE COMBINED IMMUNODEFICIENT MICE:
A Shoker, Z Sardar, H Yang, M Hussain |
Transplantation | 1999 |
Immune cell signaling aberrations in human lupus
SN Liossis, PP Sfikakis, GC Tsokos |
Immunologic Research | 1998 |
Immunotherapy for autoimmune and inflammatory renal diseases
DR Jayne |
Current Opinion in Nephrology and Hypertension | 1998 |
Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus)
JD Laman, M Meurs, MM Schellekens, M Boer, B Melchers, L Massacesi, H Lassmann, E Claassen, BA Hart |
Journal of Neuroimmunology | 1998 |
Cellular interactions in the pathogenesis of lupus nephritis: The role of T cells and macrophages in the amplification of the inflammatory process in the kidney
T Kuroiwa, EG Lee |
Lupus | 1998 |
Production of pathogenic antibodies: Cognate interactions between autoimmune T and B cells
SK Datta |
Lupus | 1998 |
Defective early T and T-dependent B cell activation in systemic lupus erythematosus
B Fernández-Gutiérrez, S Miguel, C Morado, C Hernández-García, A Bañares, JA Jover |
Lupus | 1998 |
Chronic Lymphocytic Leukemia B Cells Can Express CD40 Ligand and Demonstrate T-Cell Type Costimulatory Capacity
EJ Schattner, J Mascarenhas, I Reyfman, M Koshy, C Woo, SM Friedman, MK Crow |
Blood | 1998 |
Functional CD40 ligand is expressed by T cells in rheumatoid arthritis
KP MacDonald, Y Nishioka, PE Lipsky, R Thomas |
Journal of Clinical Investigation | 1997 |
Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand
L Georgescu, RK Vakkalanka, KB Elkon, MK Crow |
Journal of Clinical Investigation | 1997 |
Systemic lupus: basic mechanisms and prospects for specific immunotherapy
SK Datta |
Japanese Journal of Rheumatology | 1997 |
Nucleosome-driven Autoimmune Response in Lupus Pathogenic T Helper Cell Epitopes and Costimulatory Signals
SK Datta, A Kaliyaperumal |
Annals of the New York Academy of Sciences | 1997 |
Requirement of a second signal via protein kinase C or protein kinase A for maximal expression of CD40 ligand. Involvement of transcriptional and posttranscriptional mechanisms
A Suárez, L Mozo, A Gayo, J Zamorano, C Gutierrez |
European Journal of Immunology | 1997 |
Immunohistologic analysis of renal CD40 and CD40L expression in lupus nephritis and other glomerulonephritides
MJ Yellin, V D'Agati, G Parkinson, AS Han, A Szema, D Baum, D Estes, M Szabolcs, L Chess |
Arthritis & Rheumatism | 1997 |
Advances in Molecular and Cell Biology
KJ Clemetson |
Advances in Molecular and Cell Biology | 1997 |
Self antigens and epitope spreading in systemic autoimmunity
J Craft, S Fatenejad |
Arthritis & Rheumatism | 1997 |
CD40-CD40 ligand interaction in autoimmune disease
SK Datta, SL Kalled |
Arthritis & Rheumatism | 1997 |
Low-Level Production of Interleukin-13 in Synovial Fluid and Tissue from Patients with Arthritis
JM Woods, GK Haines, MR Shah, G Rayan, AE Koch |
Clinical Immunology and Immunopathology | 1997 |
Reed-Sternberg Cells and the TNF Family of Receptors/Ligands
K Clodi, A Younes |
Leukemia & Lymphoma | 1997 |
T helper cells driving pathogenic anti-DNA autoantibody production in lupus : nucleosomal epitopes and CD40 ligand signals
SK Datta, A Kaliyaperumal, C Mohan, A Desai-Mehta |
Lupus | 1997 |
T cells of lupus and molecular targets for immunotherapy
S K Datta, A Kaliyaperumal, A Desai-Mehta |
Journal of Clinical Immunology | 1997 |
Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus
A Kaliyaperumal, C Mohan, W Wu, SK Datta |
Journal of Experimental Medicine | 1996 |