Besides their phagocytic effector functions, myeloid cells have an essential role as accessory cells in the induction of optimal humoral immune responses by presenting captured antigens and activating lymphocytes. Antigen presentation by human monocytes was recently found to be enhanced in vitro through the high-affinity Fc receptor for IgG (Fc gamma RI; CD64), which is exclusively present on myeloid cells. To evaluate a comparable role of Fc gamma RI in antigen presentation in vivo, we generated human Fc gamma RI transgenic mice. Under control of its endogenous promoter, human Fc gamma RI was selectively expressed on murine myeloid cells at physiological expression levels. As in humans, expression was properly regulated by the cytokines IFN-gamma, G-CSF, IL-4, and IL-10, and was up-regulated during inflammation. The human receptor expressed by murine macrophages bound monomeric human IgG and mediated particle phagocytosis and IgG complex internalization. To evaluate whether specific targeting of antigens to Fc gamma RI can induce enhanced antibody responses, mice were immunized with an anti-human Fc gamma RI antibody containing antigenic determinants. Transgenic mice produced antigen-specific antibody responses with high IgG1 titers and substantial IgG2a and IgG2b responses. These data demonstrate that human Fc gamma RI on myeloid cells is highly active in mediating enhanced antigen presentation in vivo, and show that anti-Fc gamma RI mAbs are promising vaccine adjuvants.
I A Heijnen, M J van Vugt, N A Fanger, R F Graziano, T P de Wit, F M Hofhuis, P M Guyre, P J Capel, J S Verbeek, J G van de Winkel
Title and authors | Publication | Year |
---|---|---|
Antibody-mediated control mechanisms of viral infections
Mackin SR, Sariol A, Diamond MS |
Immunological reviews | 2024 |
SARS-CoV-2: Immunity, Challenges with Current Vaccines, and a Novel Perspective on Mucosal Vaccines.
Sunagar R, Singh A, Kumar S |
Human vaccines | 2023 |
Novel Human FCGR1A Variants Affect CD64 Functions and Are Risk Factors for Sarcoidosis.
Wu J, Li Y, Rendahl A, Bhargava M |
Frontiers in immunology | 2022 |
Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice.
Masutani Y, Takai T, Kamijo S, Kimitsu T, Yoshimura T, Ichikawa S, Shimizu S, Ogawa T, Takada K, Tominaga M, Suto H, Takamori K, Ogawa H, Okumura K, Ikeda S |
International Archives of Allergy and Immunology | 2022 |
THP-1 cells transduced with CD16A utilize Fcγ receptor I and III in the phagocytosis of IgG-sensitized human erythrocytes and platelets.
Gil Gonzalez L, Fernandez-Marrero Y, Norris PAA, Tawhidi Z, Shan Y, Cruz-Leal Y, Won KD, Frias-Boligan K, Branch DR, Lazarus AH |
PloS one | 2022 |
A Novel Recombinant Fcγ Receptor-Targeted Survivin Combines with Chemotherapy for Efficient Cancer Treatment
CC Wu, CY Chiang, SJ Liu, HW Chen |
Biomedicines | 2021 |
Neutrophils and Influenza: A Thin Line between Helpful and Harmful
ST George, J Lai, J Ma, HD Stacey, MS Miller, CE Mullarkey |
Human vaccines | 2021 |
Bimodal Targeting of Human Leukocytes by Fc- and CpG-Decorated Polymersomes to Tune Immune Induction
LF van Beek, PL Welzen, LU Teufel, I Joosten, DA Diavatopoulos, J van Hest, MI de Jonge |
Biomacromolecules | 2021 |
Harnessing the immune system via FcγR function in immune therapy: a pathway to next‐gen mAbs
AM Chenoweth, BD Wines, JC Anania, PM Hogarth |
Immunology and Cell Biology | 2020 |
Preclinical Efficacy of a Trivalent Human FcγRI-Targeted Adjuvant-Free Subunit Mucosal Vaccine against Pulmonary Pneumococcal Infection
S Kumar, R Sunagar, EJ Gosselin |
Human vaccines | 2020 |
Delivery of Antigen to CD8+ Dendritic Cells by Fusing Antigen With Formyl Peptide Receptor-Like 1 Inhibitor Protein Induces Antitumor Immunity
CY Chiang, CC Wu, YJ Chen, SJ Liu, CH Leng, HW Chen |
Frontiers in immunology | 2019 |
Mechanisms of inside-out signaling of the high-affinity IgG receptor FcγRI
AM Brandsma, SL Schwartz, MJ Wester, CC Valley, GL Blezer, G Vidarsson, KA Lidke, T ten Broeke, DS Lidke, JH Leusen |
Science signaling | 2018 |
Plant-expressed Fc-fusion protein tetravalent dengue vaccine with inherent adjuvant properties
MY Kim, A Copland, K Nayak, A Chandele, MS Ahmed, Q Zhang, GR Diogo, MJ Paul, S Hofmann, MS Yang, YS Jang, JK Ma, R Reljic |
Plant Biotechnology Journal | 2018 |
The pathophysiology of anaphylaxis
LL Reber, JD Hernandez, SJ Galli |
Journal of Allergy and Clinical Immunology | 2017 |
Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins
U Grawunder, S Barth |
Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins | 2017 |
CD64: An Attractive Immunotherapeutic Target for M1-type Macrophage Mediated Chronic Inflammatory Diseases
OA Akinrinmade, S Chetty, AK Daramola, M Islam, T Thepen, S Barth |
Biomedicines | 2017 |
Single Nucleotide Polymorphisms of the High Affinity IgG Receptor FcγRI Reduce Immune Complex Binding and Downstream Effector Functions
AM Brandsma, T Broeke, ED Hollander, TG Caniels, T Kardol-Hoefnagel, J Kuball, JH Leusen |
Journal of immunology (Baltimore, Md. : 1950) | 2017 |
Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice
CM Gillis, F Jönsson, DA Mancardi, N Tu, H Beutier, NV Rooijen, LE Macdonald, AJ Murphy, P Bruhns |
Journal of Allergy and Clinical Immunology | 2016 |
Lipidated L2 epitope repeats fused with a single-chain antibody fragment targeting human FcγRI elicited cross-neutralizing antibodies against a broad spectrum of human papillomavirus types
T Zhang, H Liu, X Chen, Z Wang, S Wang, C Qu, J Zhang, X Xu |
Vaccine | 2016 |
Compendium of Inflammatory Diseases
J El-Benna, PM Dang, M Hurtado-Nedelec |
Compendium of Inflammatory Diseases | 2016 |
FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes
EB Duffy, S Periasamy, D Hunt, JR Drake, JA Harton |
Journal of leukocyte biology | 2016 |
SLE-associated risk factors affect DC function
M Son, SJ Kim, B Diamond |
Immunological Reviews | 2015 |
Mouse and human FcR effector functions
P Bruhns, F Jönsson |
Immunological Reviews | 2015 |
Elevated Membrane and Soluble CD64: A Novel Marker Reflecting Altered FcγR Function and Disease in Early Rheumatoid Arthritis That Can Be Regulated by Anti-Rheumatic Treatment
P Matt, U Lindqvist, S Kleinau, M Kuwana |
PloS one | 2015 |
Fc Receptors
M Daeron, F Nimmerjahn |
2014 | |
Fc Receptors
M Daeron, F Nimmerjahn |
2014 | |
Fc Receptors
M Daeron, F Nimmerjahn |
2014 | |
Fc Receptors
M Daeron, F Nimmerjahn |
2014 | |
Fc Receptors
M Daeron, F Nimmerjahn |
2014 | |
Fc Receptors
M Daeron, F Nimmerjahn |
2014 | |
Fc Receptors
M Daeron, F Nimmerjahn |
2014 | |
Fc Receptors
M Daeron, F Nimmerjahn |
2014 | |
Fc Receptors
M Daeron, F Nimmerjahn |
2014 | |
Fc Receptors
M Daeron, F Nimmerjahn |
2014 | |
The function of Fcγ receptors in dendritic cells and macrophages
M Guilliams, P Bruhns, Y Saeys, H Hammad, BN Lambrecht |
Nature Reviews Immunology | 2014 |
Fc receptor-targeting of immunogen as a strategy for enhanced antigen loading, vaccination, and protection using intranasally administered antigen-pulsed dendritic cells
GH Pham, BV Iglesias, EJ Gosselin |
Vaccine | 2014 |
IgG Subclasses and Allotypes: From Structure to Effector Functions
G Vidarsson, G Dekkers, T Rispens |
Frontiers in immunology | 2014 |
Antibody Fc
MA Lindorfer, J Köhl, RP Taylor |
Antibody Fc | 2014 |
Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies
C Gillis, A Gouel-Chéron, F Jönsson, P Bruhns |
Frontiers in immunology | 2014 |
Anti-tumor activity of human IgG1 anti-gp75 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice
P Boross, JH Jansen, G Tetering, M Nederend, A Brandsma, S Meyer, E Torfs, HJ Ham, L Meulenbroek, S Haij, JH Leusen |
Immunology Letters | 2014 |
The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy
DA Mancardi, M Albanesi, F Jönsson, B Iannascoli, NV Rooijen, X Kang, P England, M Daëron, P Bruhns |
Blood | 2013 |
Oligomannose-Coated Liposome as a Novel Adjuvant for the Induction of Cellular Immune Responses to Control Disease Status
N Kojima, M Ishii, Y Kawauchi, H Takagi |
BioMed Research International | 2013 |
Molecular and Cellular Mechanisms of Antibody Activity
F Nimmerjahn |
2013 | |
Properties of mouse and human IgG receptors and their contribution to disease models
P Bruhns |
Blood | 2012 |
FcγRI (CD64): an identity card for intestinal macrophages
JD Calisto, EJ Villablanca, JR Mora |
European Journal of Immunology | 2012 |
Multiple mechanisms mediate enhanced immunity generated by mAb-inactivated F. tularensis immunogen
BV Iglesias, C Bitsaktsis, G Pham, JR Drake, KR Hazlett, K Porter, EJ Gosselin |
Immunology and Cell Biology | 2012 |
Mechanism of action of therapeutic monoclonal antibodies: promises and pitfalls of in vitro and in vivo assays
J Golay, M Introna |
Archives of Biochemistry and Biophysics | 2012 |
Physiology of the Gastrointestinal Tract, Two Volume Set
PR Kiela, JF Collins, FK Ghishan |
Physiology of the Gastrointestinal Tract, Two Volume Set | 2012 |
Development of the Vault Particle as a Platform Technology
LH Rome, VA Kickhoefer |
ACS Nano | 2012 |
Mouse model recapitulating human Fcγ receptor structural and functional diversity
P Smith, DJ DiLillo, S Bournazos, F Li, JV Ravetch |
Proceedings of the National Academy of Sciences | 2012 |
Mucosal Immunization with an Unadjuvanted Vaccine That Targets Streptococcus pneumoniae PspA to Human Fcγ Receptor Type I Protects against Pneumococcal Infection through Complement- and Lactoferrin-Mediated Bactericidal Activity
C Bitsaktsis, BV Iglesias, Y Li, J Colino, CM Snapper, SK Hollingshead, G Pham, DR Gosselin, EJ Gosselin, A Camilli |
Infection and immunity | 2011 |
Bispecific Antibodies
RE Kontermann |
2011 | |
Cytokine-induced immune complex binding to the high-affinity IgG receptor, Fc RI, in the presence of monomeric IgG
CE van der Poel, RA Karssemeijer, P Boross, JA van der Linden, M Blokland, JG van de Winkel, JH Leusen |
Blood | 2010 |
CD4 + T Cells and Antibody Are Required for Optimal Major Outer Membrane Protein Vaccine-Induced Immunity to Chlamydia muridarum Genital Infection
CM Farris, SG Morrison, RP Morrison |
Infection and immunity | 2010 |
Activating and inhibitory Fcγ receptors in immunotherapy: being the actor or being the target
R Abès, CA Dutertre, L Agnelli, JL Teillaud |
Expert Review of Clinical Immunology | 2009 |
Fc receptor-targeted mucosal vaccination as a novel strategy for the generation of enhanced immunity against mucosal and non-mucosal pathogens
EJ Gosselin, C Bitsaktsis, Y Li, BV Iglesias |
Archivum Immunologiae et Therapiae Experimentalis | 2009 |
A Vault Nanoparticle Vaccine Induces Protective Mucosal Immunity
CI Champion, VA Kickhoefer, G Liu, RJ Moniz, AS Freed, LL Bergmann, D Vaccari, S Raval-Fernandes, AM Chan, LH Rome, KA Kelly, D Unutmaz |
PloS one | 2009 |
Utilization of Immunoglobulin G Fc Receptors by Human Immunodeficiency Virus Type 1: a Specific Role for Antibodies against the Membrane-Proximal External Region of gp41
LG Perez, MR Costa, CA Todd, BF Haynes, DC Montefiori |
Journal of virology | 2009 |
Neutrophils in antibody-based immunotherapy of cancer
M Egmond |
Expert Opinion on Biological Therapy | 2008 |
Surfactant protein D/anti-Fc receptor bifunctional proteins as a tool to enhance host defence
EC Breij, JJ Batenburg |
Expert Opinion on Biological Therapy | 2008 |
Targeting allergen to Fc gammaRI: a strategy to treat allergic disease?
KE Hulse, JA Woodfolk |
Current Opinion in Allergy and Clinical Immunology | 2008 |
Malaria vaccines: immunity, models and monoclonal antibodies
L Hviid, L Barfod |
Trends in Parasitology | 2008 |
Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion*
X Li, K Su, C Ji, AJ Szalai, J Wu, Y Zhang, T Zhou, RP Kimberly, JC Edberg |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Utilization of Fc Receptors as a Mucosal Vaccine Strategy against an Intracellular Bacterium, Francisella tularensis1
DB Rawool, C Bitsaktsis, Y Li, DR Gosselin, Y Lin, NV Kurkure, DW Metzger, EJ Gosselin |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Filamin A Stabilizes FcγRI Surface Expression and Prevents Its Lysosomal Routing
JM Beekman, CE van der Poel, JA van der Linden, DL van den Berg, PV van den Berghe, JG van de Winkel, JH Leusen |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Immune Opsonins Modulate BLyS/BAFF Release in a Receptor-Specific Fashion
X Li, K Su, C Ji, AJ Szalai, J Wu, Y Zhang, T Zhou, RP Kimberly, JC Edberg |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Utilization of Fc Receptors as a Mucosal Vaccine Strategy against an Intracellular Bacterium, Francisella tularensis
DB Rawool, C Bitsaktsis, Y Li, DR Gosselin, Y Lin, NV Kurkure, DW Metzger, EJ Gosselin |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting
PJ Tacken, IJ de Vries, R Torensma, CG Figdor |
Nature Reviews Immunology | 2007 |
Prostaglandin E2 modulates dendritic cell function during chlamydial genital infection
W Liu, KA Kelly |
Immunology | 2007 |
A novel Fcγ receptor ligand augments humoral responses by targeting antigen to Fcγ receptors
MA Jensen, BG Arnason, DM White |
European Journal of Immunology | 2007 |
Enhanced transduction of dendritic cells by FcγRI-targeted adenovirus vectors
R Sapinoro, CA Maguire, A Burgess, S Dewhurst |
The Journal of Gene Medicine | 2007 |
The Biology of Dendritic Cells and HIV Infection
S Gessani, F Belardelli |
2007 | |
The Importance of Human FcγRI in Mediating Protection to Malaria
RS McIntosh, J Shi, RM Jennings, JC Chappel, TF de Koning-Ward, T Smith, J Green, M van Egmond, JH Leusen, M Lazarou, J van de Winkel, TS Jones, BS Crabb, AA Holder, RJ Pleass, J Kazura |
PLoS pathogens | 2007 |
CD64-directed immunotoxin inhibits arthritis in a novel CD64 transgenic rat model
AJ van Vuuren, JA van Roon, V Walraven, I Stuij, MC Harmsen, PM McLaughlin, JG van de Winkel, T Thepen |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
Monocyte CD64 or CD89 targeting by surfactant protein D/anti-Fc receptor mediates bacterial uptake
PJ Tacken, JJ Batenburg |
Immunology | 2006 |
Direct targeting of genetically modified tumour cells to FcγRI triggers potent tumour cytotoxicity
L Bevaart, J Goldstein, L Vitale, C Russoniello, J Treml, J Zhang, RF Graziano, JH Leusen, JG Winkel, T Keler |
British Journal of Haematology | 2006 |
Combination vaccines: design strategies and future trends
JU Igietseme, FO Eko, Q He, CM Black |
Expert Review of Vaccines | 2006 |
Targeting antigens to dendritic cells in vivo
PJ Tacken, R Torensma, CG Figdor |
Immunobiology | 2006 |
Direct targeting of genetically modified tumour cells to Fc gammaRI triggers potent tumour cytotoxicity
L Bevaart, J Goldstein, L Vitale, C Russoniello, J Treml, J Zhang, RF Graziano, JH Leusen, JG van de Winkel, T Keler |
British Journal of Haematology | 2006 |
Characterization of an FcγRI-binding peptide selected by phage display
G Berntzen, OH Brekke, SA Mousavi, JT Andersen, TE Michaelsen, T Berg, I Sandlie, V Lauvrak |
Protein Engineering Design and Selection | 2006 |
Protein Kinase Bα Is Required for Vesicle Trafficking and Class II Presentation of IgA Fc Receptor (CD89)-Targeted Antigen
GA Lang, ML Lang |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
The potential of exosomes in immunotherapy
N Chaput, J Taïeb, F André, L Zitvogel |
Expert Opinion on Biological Therapy | 2005 |
IgG3-Mediated Enhancement of the Antibody Response is Normal in FcgammaRI-Deficient Mice
F Hjelm, F Carlsson, S Verbeek, B Heyman |
Scandinavian Journal of Immunology | 2005 |
Regulation of B-Cell Activation by Complement Receptors and Fc Receptors
CH Nielsen, RG Leslie |
Transfusion Medicine and Hemotherapy | 2005 |
Delivery ofChlamydiavaccines
J Igietseme, F Eko, Q He, C Bandea, W Lubitz, A Garcia-Sastre, C Black |
Expert Opinion on Drug Delivery | 2005 |
Enhanced Antigen-Specific Antibody and Cytokine Responses When Targeting Antigen to Human FcGAMMA Receptor Type I Using an Anti-Human FcGAMMA Receptor Type I-Streptavidin Fusion Protein in an Adjuvant-Free System
E Adamova, MC Walsh, DR Gosselin, K Hale, MT Preissler, RF Graziano, EJ Gosselin |
Immunological Investigations | 2005 |
IgG2a-Mediated Enhancement of Antibody and T Cell Responses and Its Relation to Inhibitory and Activating Fcγ Receptors
A Getahun, J Dahlström, S Wernersson, B Heyman |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Antibody regulation of T-cell immunity: implications for vaccine strategies against intracellular pathogens
JU Igietseme, FO Eko, Q He, CM Black |
Expert Review of Vaccines | 2004 |
Depletion of synovial macrophages in rheumatoid arthritis by an anti-FcgammaRI-calicheamicin immunoconjugate
JA van Roon, JW Bijlsma, JG van de Winkel, FP Lafeber |
Annals of the rheumatic diseases | 2004 |
Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity
JM Beekman, JE Bakema, JG van de Winkel, JH Leusen |
Proceedings of the National Academy of Sciences | 2004 |
IgG- and IgE-mediated antigen presentation on MHC class II
A Getahun, B Heyman |
Immunology Letters | 2004 |
Modulation of FcγRI (CD64) Ligand Binding by Blocking Peptides of Periplakin
JM Beekman, JE Bakema, J der Linden, B Tops, M Hinten, M Vugt, JG van de Winkel, JH Leusen |
The Journal of biological chemistry | 2004 |
Handbook of Cancer Vaccines
MA Morse, TM Clay, HK Lyerly |
2004 | |
Contemporary approaches to designing and evaluating vaccines against Chlamydia
JU Igietseme, FO Eko, CM Black |
Expert Review of Vaccines | 2003 |
A two-component modular approach for enhancing T-cell activation utilizing a unique anti-FcγRI-streptavidin construct and microspheres coated with biotinylated-antigen
MC Walsh, JA Banas, SP Mudzinski, MT Preissler, RF Graziano, EJ Gosselin |
Biomolecular Engineering | 2003 |
Selective elimination of synovial inflammatory macrophages in rheumatoid arthritis by an Fc? receptor I-directed immunotoxin
JA Roon, AJ Vuuren, S Wijngaarden, KM Jacobs, JW Bijlsma, FP Lafeber, T Thepen, JG Winkel |
Arthritis & Rheumatism | 2003 |
New Trends in Cancer for the 21stCentury
A Llombart-Bosch, V Felipo |
2003 | |
Unique Monoclonal Antibodies Define Expression of FcγRI on Macrophages and Mast Cell Lines and Demonstrate Heterogeneity Among Subcutaneous and Other Dendritic Cells
PS Tan, AL Gavin, N Barnes, DW Sears, D Vremec, K Shortman, S Amigorena, PL Mottram, PM Hogarth |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
C-reactive protein-mediated phagocytosis and phospholipase D signalling through the high-affinity receptor for immunoglobulin G (FcgammaRI)
KB Bodman-Smith, AJ Melendez, I Campbell, PT Harrison, JM Allen, JG Raynes |
Immunology | 2002 |
Immune complex–mediated antigen presentation induces tumor immunity
K Rafiq, A Bergtold, R Clynes |
Journal of Clinical Investigation | 2002 |
Enhanced killing of B lymphoma cells by granulocyte colony-stimulating factor-primed effector cells and Hu1D10 - a humanized human leucocyte antigen DR antibody
B Stockmeyer, M Schiller, R Repp, HM Lorenz, JR Kalden, M Gramatzki, T Valerius |
British Journal of Haematology | 2002 |
Neutrophil Fc gamma RI as target for immunotherapy of invasive candidiasis
A B van Spriel, I E van den Herik-Oudijk, J G van de Winkel |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Subcutaneous Administration of Interleukin-2 Triggers Fcγ Receptor I Expression on Human Peripheral Blood Neutrophils in Solid and Hematologic Malignancies
G Sconocchia, NY Cococcetta, L Campagnano, S Amadori, B Iorio, V Boffo, V Ferdinandi, ID Principe, D Adorno, CU Casciani |
Journal of Immunotherapy | 2001 |
Role of Activatory FcγRI and FcγRIII and Inhibitory FcγRII in Inflammation and Cartilage Destruction during Experimental Antigen-Induced Arthritis
PL van Lent, K Nabbe, AB Blom, AE Holthuysen, A Sloetjes, LB van de Putte, S Verbeek, WB van Berg |
The American Journal of Pathology | 2001 |
MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells
X Zhu, G Meng, BL Dickinson, X Li, E Mizoguchi, L Miao, Y Wang, C Robert, B Wu, PD Smith, WI Lencer, RS Blumberg |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Role of activatory Fc gamma RI and Fc gamma RIII and inhibitory Fc gamma RII in inflammation and cartilage destruction during experimental antigen-induced arthritis
PL van Lent, K Nabbe, AB Blom, AE Holthuysen, A Sloetjes, LB van de Putte, S Verbeek, WB van Berg |
The American Journal of Pathology | 2001 |
Cancer immunotherapy: insights from transgenic animal models
PM McLaughlin, BJ Kroesen, MC Harmsen, LF de Leij |
Critical Reviews in Oncology/Hematology | 2001 |
Bispecific antibody-targeted phagocytosis of HER-2/neu expressing tumor cells by myeloid cells activated in vivo
PK Wallace, PA Kaufman, LD Lewis, T Keler, AL Givan, JL Fisher, MG Waugh, AE Wahner, PM Guyre, MW Fanger, MS Ernstoff |
Journal of Immunological Methods | 2001 |
Introduction: bispecific antibodies
DM Segal, GJ Weiner, LM Weiner |
Journal of Immunological Methods | 2001 |
Mechanisms of G-CSF- or GM-CSF-stimulated tumor cell killing by Fc receptor-directed bispecific antibodies
B Stockmeyer, D Elsässer, M Dechant, R Repp, M Gramatzki, MJ Glennie, JG van de Winkel, T Valerius |
Journal of Immunological Methods | 2001 |
Cytotoxicity of Anti-CD64-Ricin A Chain Immunotoxin Against Human Acute Myeloid Leukemia Cells In Vitro and in SCID Mice
RK Zhong, JG de Winkel, T Thepen, LD Schultz, ED Ball |
Journal of Hematotherapy & Stem Cell Research | 2001 |
Mac-1 (CD11b/CD18) is essential for Fc receptor–mediated neutrophil cytotoxicity and immunologic synapse formation
AB van Spriel, JH Leusen, M van Egmond, HB Dijkman, KJ Assmann, TN Mayadas, JG van de Winkel |
Blood | 2001 |
Colocalization of FcγRI-Targeted Antigen With Class I MHC: Implications for Antigen Processing
CA Guyre, ME Barreda, SL Swink, MW Fanger |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Protein tyrosine phosphatase εC selectively inhibits interleukin-6– and interleukin- 10–induced JAK-STAT signaling
N Tanuma, H Shima, K Nakamura, K Kikuchi |
Blood | 2001 |
Receptor Modulation by FcγRI-Specific Fusion Proteins Is Dependent on Receptor Number and Modified by IgG
CA Guyre, T Keler, SL Swink, LA Vitale, RF Graziano, MW Fanger |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Targeting weak antigens to CD64 elicits potent humoral responses in human CD64 transgenic mice
T Keler, PM Guyre, LA Vitale, K Sundarapandiyan, JG van de Winkel, YM Deo, RF Graziano |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Immunotherapeutic perspective for bispecific antibodies
AB van Spriel, HH van Ojik, JG van de Winkel |
Immunology Today | 2000 |
Triggering Fc alpha-receptor I (CD89) recruits neutrophils as effector cells for CD20-directed antibody therapy
B Stockmeyer, M Dechant, M Egmond, AL Tutt, K Sundarapandiyan, RF Graziano, R Repp, JR Kalden, M Gramatzki, MJ Glennie, JG van de Winkel, T Valerius |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Resolution of cutaneous inflammation after local elimination of macrophages
T Thepen, AJ van Vuuren, RC Kiekens, CA Damen, WC Vooijs, JG van de Winkel |
Nature Biotechnology | 2000 |
Macrophages and cutaneous inflammation
TS McCormick, SR Stevens, K Kang |
Nature Biotechnology | 2000 |
Immune Complex and Fc Receptor-Mediated Augmentation of Antigen Presentation for in Vivo Th Cell Responses
Y Hamano, H Arase, H Saisho, T Saito |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Therapeutic efficacy of FcγRI/CD64-directed bispecific antibodies in B-cell lymphoma
J Honeychurch, AL Tutt, T Valerius, IA Heijnen, JG de Winkel, MJ Glennie |
Blood | 2000 |
On the role of complement and Fc γ-receptors in the Arthus reaction
J Köhl, JE Gessner |
Molecular Immunology | 1999 |
GM-CSF as adjuvant for immunotherapy with bispecific antibodies
D Elsässer |
European Journal of Cancer | 1999 |
Influence of the Human High-Affinity IgG Receptor FcγRI (CD64) on Residual Infectivity of Neutralized Dengue Virus
JJ Schlesinger, SE Chapman |
Virology | 1999 |
Human Immunoglobulin A Receptor (FcRI, CD89) Function in Transgenic Mice Requires Both FcR γ Chain and CR3 (CD11b/CD18)
M van Egmond, AJ van Vuuren, HC Morton, AB van Spriel, L Shen, FM Hofhuis, T Saito, TN Mayadas, JS Verbeek, JG van de Winkel |
Blood | 1999 |
The FcγRIa (CD64) Ligand Binding Chain Triggers Major Histocompatibility Complex Class II Antigen Presentation Independently of Its Associated FcR γ-Chain
MJ van Vugt, MJ Kleijmeer, T Keler, I Zeelenberg, MA van Dijk, JH Leusen, HJ Geuze, JG van de Winkel |
Blood | 1999 |
Interleukin-10 (IL-10) Selectively Enhances CIS3/SOCS3 mRNA Expression in Human Neutrophils: Evidence for an IL-10–Induced Pathway That Is Independent of STAT Protein Activation
MA Cassatella, S Gasperini, C Bovolenta, F Calzetti, M Vollebregt, P Scapini, M Marchi, R Suzuki, A Suzuki, A Yoshimura |
Blood | 1999 |
IFN-γ induces the high-affinity Fc receptor I for IgG (CD64) on human glomerular mesangial cells
P Uciechowski, M Schwarz, JE Gessner, RE Schmidt, K Resch, HH Radeke |
European Journal of Immunology | 1998 |
MUC1 cross-reactive Galα(l,3)Gal antibodies in humans switch immune responses from cellular to humoral
V Apostolopoulos, C Osinski, IF Mckenzie |
Nature Medicine | 1998 |
Regulation of murine hypersensitive responses by Fc receptors
T Takai, M Ono, A Ujike, T Yuasa |
Allergology International | 1998 |
The neutrophil: one of the cellular targets of interleukin-10
MA Cassatella |
International Journal of Clinical & Laboratory Research | 1998 |
Macrophage-targeted killing and vaccines
CA Guyre, MW Fanger |
Research in Immunology | 1998 |
The second and third extracellular domains of Fc γ RI (CD64) confer the unique high affinity binding of IgG2a
MD Hulett, PM Hogarth |
Molecular Immunology | 1998 |
The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity
JG van de Winkel, PM Hogarth |
1998 | |
Fc Receptors as Targets for Immunotherapy
H Rouard, S Tamasdan, J Moncuit, S Moutel, J Michon, WH Fridman, JL Teillaud |
International Reviews of Immunology | 1997 |
Human IgG Fc Receptors
IA Heijnen, JG van de Winkel |
International Reviews of Immunology | 1997 |
Structural Bases of FcγR Functions
M Daéron |
International Reviews of Immunology | 1997 |
FcRECEPTOR BIOLOGY
M Daëron |
Annual Review of Immunology | 1997 |
Bispecific antibodies for the treatment of tumours and infectious diseases
DL Drakeman, MW Fanger, PK Wallace |
Expert Opinion on Investigational Drugs | 1997 |
Clinical significance of IgG Fc receptors and FcγR-directed immunotherapies
YM Deo, RF Graziano, R Repp, JG van de Winkel |
Immunology Today | 1997 |
Natural anti-Gal antibody as a universal augmenter of autologous tumor vaccine immunogenicity
U Galili, DC LaTemple |
Immunology Today | 1997 |
FcαRI (CD89) as a Novel Trigger Molecule for Bispecific Antibody Therapy
T Valerius, B Stockmeyer, AB van Spriel, RF Graziano, IE van den Herik-Oudijk, R Repp, YM Deo, J Lund, JR Kalden, M Gramatzki, JG van de Winkel |
Blood | 1997 |
F(c)gammaRI-targeted fusion proteins result in efficient presentation by human monocytes of antigenic and antagonist T cell epitopes
C Liu, J Goldstein, RF Graziano, J He, JK O'Shea, Y Deo, PM Guyre |
Journal of Clinical Investigation | 1996 |
Cell-Mediated Effects of Immunoglobulins
WH Fridman, C Sautès |
1996 |