JCI - Citations to Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy.

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Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy.

K Kaushansky, … , J W Forstrom, K H Sprugel

K Kaushansky, … , J W Forstrom, K H Sprugel

Published September 1, 1995
Citation Information: J Clin Invest. 1995;96(3):1683-1687. https://doi.org/10.1172/JCI118210.

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Title and authors	Publication	Year
Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome. Vercellino J, Małachowska B, Kulkarni S, Bell BI, Shajahan S, Shinoda K, Eichenbaum G, Verma AK, Ghosh SP, Yang WL, Frenette PS, Guha C	Research square	2024
Thrombopoietin, the Primary Regulator of Platelet Production: From Mythos to Logos, a Thirty-Year Journey Kaushansky K	Biomolecules	2024
Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome Vercellino J, Małachowska B, Kulkarni S, Bell BI, Shajahan S, Shinoda K, Eichenbaum G, Verma AK, Ghosh SP, Yang WL, Frenette PS, Guha C	Stem Cell Research & Therapy	2024
Oncogenic Calreticulin Induces Immune Escape by Stimulating TGF-β Expression and Regulatory T Cell Expansion in the Bone Marrow Microenvironment Schmidt D, Endres C, Hoefflin R, Andrieux G, Zwick M, Karantzelis N, Staehle HF, Vinnakota JM, Duquesne S, Mozaffari M, Pfeifer D, Becker H, Blazar BR, Zähringer A, Duyster J, Brummer T, Boerries M, Baumeister J, Shoumariyeh K, Li J, Green AR, Heidel FH, Tirosh I, Pahl HL, Leimkühler N, Köhler N, de Toledo MA, Koschmieder S, Zeiser R	Cancer research	2024
In Silico Evaluation of Coding and Non-Coding nsSNPs in the Thrombopoietin Receptor (MPL) Proto-Oncogene: Assessing Their Influence on Protein Stability, Structure, and Function. Al-Nakhle HH, Yagoub HS, Anbarkhan SH, Alamri GA, Alsubaie NM	Current issues in molecular biology	2023
Endocytosis of the thrombopoietin receptor Mpl regulates megakaryocyte and erythroid maturation in mice. Eaton N, Boyd EK, Biswas R, Lee-Sundlov MM, Dlugi TA, Ramsey HE, Zheng S, Burns RT, Sola-Visner MC, Hoffmeister KM, Falet H	Frontiers in Oncology	2022
A Novel Combination Therapy of Erythropoietin and Thrombopoietin to Treat Erythropoietin-Resistance anemia. Zou H, Xu P, Wong RSM, Yan X	Pharmaceutical Research	2022
The Role of Megakaryocytes in Myelofibrosis J Melo-Cardenas, AR Migliaccio, JD Crispino	Hematology/Oncology Clinics of North America	2021
Macrophages Derived From Human Induced Pluripotent Stem Cells: The Diversity of Protocols, Future Prospects, and Outstanding Questions I Lyadova, T Gerasimova, T Nenasheva	Frontiers in Cell and Developmental Biology	2021
In vitro expansion of fetal liver hematopoietic stem cells R Bhardwaj, L Kumar, D Chhabra, NK Mehra, A sharma, S Mohanty, V Kochupillai	Scientific Reports	2021
GPIbα is the driving force of hepatic thrombopoietin generation D Karakas, M Xu, H Ni	Research and Practice in Thrombosis and Haemostasis	2021
In and out: Traffic and dynamics of thrombopoietin receptor A Roy, S Shrivastva, S Naseer	Journal of Cellular and Molecular Medicine	2021
Current evidence and the emerging role of eltrombopag in severe aplastic anemia B Drexler, J Passweg	Therapeutic Advances in Hematology	2021
Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma SR Hyslop, M Alexander, AA Thai, A Kersbergen, AJ Kueh, MJ Herold, J Corbin, P Gangatirkar, AP Ng, BJ Solomon, WS Alexander, KD Sutherland, EC Josefsson	Oncogene	2020
MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment J Grabek, J Straube, M Bywater, SW Lane	Cells	2020
Crosstalk Between the Hepatic and Hematopoietic Systems During Embryonic Development F Soares-da-Silva, M Peixoto, A Cumano, P Pinto-do-Ó	Frontiers in Cell and Developmental Biology	2020
Slc35a1 deficiency causes thrombocytopenia due to impaired megakaryocytopoiesis and excessive platelet clearance in the liver X Ma, Y Li, Y Kondo, H Shi, J Han, Y Jiang, X Bai, SA Archer-Hartmann, P Azadi, C Ruan, J Fu, L Xia, SU of Hematology	Haematologica	2020
Post-Transcriptional Expression Control in Platelet Biogenesis and Function CT Neu, T Gutschner, M Haemmerle	International journal of molecular sciences	2020
Rescue treatment with eltrombopag in refractory cytopenias after allogeneic stem cell transplantation Aydin S, Dellacasa C, Manetta S, Giaccone L, Godio L, Iovino G, Bruno B, Busca A	Therapeutic Advances in Hematology	2020
Thrombopoietin receptor agonist is more effective than platelet transfusion for chronic liver disease with thrombocytopenia, shown by propensity score matching Y Furuichi, H Takeuchi, Y Yoshimasu, Y Kasai, M Abe, T Itoi	Hepatology Research	2020
c-MYB and DMTF1 in Cancer EA Fry, K Inoue	Cancer Investigation	2019
Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ LJ Alvarado, HD Huntsman, H Cheng, DM Townsley, T Winkler, X Feng, CE Dunbar, NS Young, A Larochelle	Blood	2019
Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury W Bain, T Olonisakin, M Yu, Y Qu, M Hulver, Z Xiong, H Li, J Pilewski, RK Mallampalli, M Nouraie, A Ray, P Ray, Z Cheng, RM Shanks, CS Croix, RL Silverstein, JS Lee	Blood Advances	2019
Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources Y Seo, KH Shin, HH Kim, HS Kim	Stem Cells International	2019
Characterization of a transgenic mouse model of chronic conditional platelet depletion LM Wuescher, S Nishat, RG Worth	Research and Practice in Thrombosis and Haemostasis	2019
The marrow stem cell niche in normal and malignant hematopoiesis: The marrow stem cell niche K Kaushansky, H Zhan	Annals of the New York Academy of Sciences	2019
Clinical and morphological predictors of outcome in older aplastic anemia patients treated with eltrombopag B Fattizzo, AG Kulasekararaj, A Hill, N Benson-Quarm, M Griffin, T Munir, L Arnold, K Riley, R Ireland, HD Lavallade, V Potter, D Consonni, P Hillmen, GJ Mufti, W Barcellini, JC Marsh	Haematologica	2019
Eltrombopag: Role in Cytopenias Following Hematopoietic Stem Cell Transplantation RV Nampoothiri, R Kumar	Indian Journal of Hematology and Blood Transfusion	2019
JAK2V617F Megakaryocytes Promote Hematopoietic Stem/Progenitor Cell Expansion in Mice Through Thrombopoietin/MPL Signaling: TPO/MPL in JAK2V617F MK-Induced Myeloproliferation Y Zhang, CH Lin, K Kaushansky, H Zhan	Stem Cells	2018
Activity of eltrombopag in severe aplastic anemia P Scheinberg	Blood Advances	2018
Activity of eltrombopag in severe aplastic anemia P Scheinberg	Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program	2018
Emerging Concepts in Immune Thrombocytopenia M Swinkels, M Rijkers, J Voorberg, G Vidarsson, FW Leebeek, AJ Jansen	Frontiers in immunology	2018
Peering through zebrafish to understand inherited bone marrow failure syndromes U Oyarbide, J Topczewski, SJ Corey	Haematologica	2018
Hematopoietic Cytokine Gene Duplication in Zebrafish Erythroid and Myeloid Lineages J Oltova, O Svoboda, P Bartunek	Frontiers in Cell and Developmental Biology	2018
iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors D Melguizo-Sanchis, Y Xu, D Taheem, M Yu, K Tilgner, T Barta, K Gassner, G Anyfantis, T Wan, R Elango, S Alharthi, AA El-Harouni, S Przyborski, S Adam, G Saretzki, S Samarasinghe, L Armstrong, M Lako	Cell Death and Disease	2018
Leukemic mature B-cell neoplasm observed during the treatment with romiplostim in patient with thrombocytopenia and liver cirrhosis M Osawa, H Akiyama, S Mae, Y Fujiwara, M Yamane	Clinical Case Reports	2018
The regulation of normal and neoplastic hematopoiesis is dependent on microenvironmental cells K Kaushansky, H Zhan	Advances in Biological Regulation	2018
Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations SC Lee, K North, E Kim, E Jang, E Obeng, SX Lu, B Liu, D Inoue, A Yoshimi, M Ki, M Yeo, XJ Zhang, MK Kim, H Cho, YR Chung, J Taylor, BH Durham, YJ Kim, A Pastore, S Monette, J Palacino, M Seiler, S Buonamici, PG Smith, BL Ebert, RK Bradley, O Abdel-Wahab	Cancer Cell	2018
Thrombopoietin knock-in augments platelet generation from human embryonic stem cells L Zhang, C Liu, H Wang, D Wu, P Su, M Wang, J Guo, S Zhao, S Dong, W Zhou, C Arakaki, X Zhang, J Zhou	Stem Cell Research & Therapy	2018
Use of Eltrombopag in Improving Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation S Master, A Dwary, R Mansour, GM Mills, N Koshy	Case reports in oncology	2018
Concise Review: Bipotent Megakaryocytic-Erythroid Progenitors: Concepts and Controversies: MEP: Concepts and Controversies J Xavier-Ferrucio, DS Krause	Stem Cells	2018
Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance M Decker, J Leslie, Q Liu, L Ding	Science	2018
The JAK2V617F-bearing vascular niche promotes clonal expansion in myeloproliferative neoplasms H Zhan, CH Lin, Y Segal, K Kaushansky	Leukemia	2017
Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling AE Au, M Lebois, SA Sim, P Cannon, J Corbin, P Gangatirkar, CD Hyland, D Moujalled, A Rutgersson, F Yassinson, BT Kile, KD Mason, AP Ng, WS Alexander, EC Josefsson	Scientific Reports	2017
The thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature M Zingariello, L Sancillo, F Martelli, F Ciaffoni, M Marra, L Varricchio, RA Rana, C Zhao, JD Crispino, AR Migliaccio	Blood Cancer Journal	2017
[Advances on thrombopoietin receptor agonist in severe aplastic anemia] J Du, F K Zhang	Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi	2017
The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors E Lefrançais, G Ortiz-Muñoz, A Caudrillier, B Mallavia, F Liu, DM Sayah, EE Thornton, MB Headley, T David, SR Coughlin, MF Krummel, AD Leavitt, E Passegué, MR Looney	Nature	2017
Genetic Alterations of the Thrombopoietin/MPL/JAK2 Axis Impacting Megakaryopoiesis I Plo, C Bellanné-Chantelot, M Mosca, S Mazzi, C Marty, W Vainchenker	Frontiers in Endocrinology	2017
Bone marrow failure unresponsive to bone marrow transplant is caused by mutations in thrombopoietin A Seo, M Ben-Harosh, M Sirin, J Stein, O Dgany, J Kaplelushnik, M Hoenig, U Pannicke, M Lorenz, K Schwarz, C Stockklausner, T Walsh, S Gulsuner, MK Lee, A Sendamarai, M Sanchez-Bonilla, MC King, H Cario, AE Kulozik, KM Debatin, A Schulz, H Tamary, A Shimamura	Blood	2017
The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin LN Varghese, JP Defour, C Pecquet, SN Constantinescu	Frontiers in Endocrinology	2017
Thrombopoietin Receptor Agonist Mitigates Hematopoietic Radiation Syndrome and Improves Survival after Whole-Body Ionizing Irradiation Followed by Wound Trauma JG Kiang, M Zhai, PJ Liao, C Ho, NV Gorbunov, TB Elliott	Mediators of Inflammation	2017
Diagnosis and Treatment of Aplastic Anemia SA Peslak, T Olson, DV Babushok	Current Treatment Options in Oncology	2017
Loss of Ezh2 cooperates with Jak2V617F in the development of myelofibrosis in a mouse model of myeloproliferative neoplasm Y Yang, H Akada, D Nath, RE Hutchison, G Mohi	Blood	2016
JAK2V617F-mutant vascular niche contributes to JAK2V617F clonal expansion in myeloproliferative neoplasms CH Lin, K Kaushansky, H Zhan	Blood Cells, Molecules, and Diseases	2016
H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets HD Liu, AJ Zhang, JJ Xu, Y Chen, YC Zhu	Journal of Hematology & Oncology	2016
The contribution of mouse models to the understanding of constitutional thrombocytopenia C Leon, A Dupuis, C Gachet, F Lanza	Haematologica	2016
RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis JE Draper, P Sroczynska, O Tsoulaki, HS Leong, MZ Fadlullah, C Miller, V Kouskoff, G Lacaud, HL Grimes	PLoS genetics	2016
Evolving insights into the synergy between erythropoietin and thrombopoietin and the bipotent erythroid/megakaryocytic progenitor cell T Papayannopoulou, K Kaushansky	Experimental Hematology	2016
Haemopedia: An Expression Atlas of Murine Hematopoietic Cells CA de Graaf, J Choi, TM Baldwin, JE Bolden, KA Fairfax, AJ Robinson, C Biben, C Morgan, K Ramsay, AP Ng, M Kauppi, EA Kruse, TJ Sargeant, N Seidenman, A D'Amico, MC D'Ombrain, EC Lucas, S Koernig, A Baz Morelli, MJ Wilson, SK Dower, B Williams, SY Heazlewood, Y Hu, SK Nilsson, L Wu, GK Smyth, WS Alexander, DJ Hilton	Stem Cell Reports	2016
Nontransplant therapy for bone marrow failure DM Townsley, T Winkler	Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program	2016
Cell cycle regulation of hematopoietic stem or progenitor cells S Hao, C Chen, T Cheng	International Journal of Hematology	2016
Modeling Human Bone Marrow Failure Syndromes Using Pluripotent Stem Cells and Genome Engineering M Jung, CE Dunbar, T Winkler	Molecular Therapy	2015
Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance S Kohlscheen, S Wintterle, A Schwarzer, C Kamp, MH Brugman, DC Breuer, G Büsche, C Baum, U Modlich, Z Ivanovic	PloS one	2015
Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program HJ Park, J Li, R Hannah, S Biddie, AI Leal-Cervantes, K Kirschner, DF Cruz, V Sexl, B Go ttgens, AR Green	The EMBO Journal	2015
Origins of the Vertebrate Erythro/Megakaryocytic System O Svoboda, P Bartunek	BioMed Research International	2015
Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene L Wang, W Cai, W Zhang, X Chen, W Dong, D Tang, Y Zhang, C Ji, M Zhang	Oncotarget	2015
Role of thrombocytopenia in radiation-induced mortality and review of therapeutic approaches targeting platelet regeneration after radiation exposure AL DiCarlo, JM Kaminski, RJ Hatchett, BW Maidment	Journal of Radiation Oncology	2015
The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm V Sangkhae, SL Etheridge, K Kaushansky, IS Hitchcock	Blood	2014
A novel conditional platelet depletion mouse model reveals the importance of platelets in protection against Staphylococcus aureus bacteremia LM Wuescher, A Takashima, RG Worth	Journal of Thrombosis and Haemostasis	2014
Management of thrombocytopenia due to liver cirrhosis: a review H Hayashi, T Beppu, K Shirabe, Y Maehara, H Baba	World journal of gastroenterology : WJG	2014
Erythropoiesis from Human Embryonic Stem Cells Through Erythropoietin-Independent AKT Signaling: EPO-Independent Erythropoiesis from hESC WS Kim, Y Zhu, Q Deng, CJ Chin, CB He, AJ Grieco, GG Dravid, C Parekh, RP Hollis, TF Lane, EE Bouhassira, DB Kohn, GM Crooks	Stem Cells	2014
Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin O Svoboda, DL Stachura, O Macho ova, P Pajer, J Brynda, LI Zon, D Traver, P Bart n k	Blood	2014
Relationship of different platelet response criteria and patient outcomes in a romiplostim myelodysplastic syndromes trial U Platzbecker, MA Sekeres, H Kantarjian, A Giagounidis, GJ Mufti, C Jia, AS Yang, P Fenaux	Leukemia	2014
Myeloproliferative Disorders B Meier, JH Burton	Emergency Medicine Clinics of North America	2014
Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation AP Ng, M Kauppi, D Metcalf, CD Hyland, EC Josefsson, M Lebois, JG Zhang, TM Baldwin, LD Rago, DJ Hilton, WS Alexander	Proceedings of the National Academy of Sciences	2014
STAT5 in hematopoietic stem cell biology and transplantation Z Wang, KD Bunting	JAK-STAT	2013
Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes DM Townsley, R Desmond, CE Dunbar, NS Young	International Journal of Hematology	2013
The biology of thrombopoietin and thrombopoietin receptor agonists DJ Kuter	International Journal of Hematology	2013
Seldin and Giebisch's The Kidney CJ Cooper, LD Dworkin, WL Henrich	Seldin and Giebisch's The Kidney	2013
Thrombopoietin modulates the proliferation, migration and cytokine profile of decidual cell subsets during early gestation SE Segerer, F Martignoni, A Bogdan, N Muller, M Kapp, J Dietl, L Rieger, U Kammerer	Molecular Human Reproduction	2013
Growth of erythroid cells from thawed unseparated cord blood in vitro without exogenous erythropoietin S Juutistenaho, S Möttönen, M Eskola, K Aranko, R Kekomäki	Transfusion and Apheresis Science	2013
Eosinophils in Health and Disease GJ Gleich	Eosinophils in Health and Disease	2013
Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia JZ Tang, CL Carmichael, W Shi, D Metcalf, AP Ng, CD Hyland, NA Jenkins, NG Copeland, VM Howell, ZJ Zhao, GK Smyth, BT Kile, WS Alexander	Proceedings of the National Academy of Sciences	2013
A numerical analysis model for the interpretation of in vivo platelet consumption data TS Strom	PloS one	2013
Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug Ronan Desmond, Danielle M Townsley, Bogdan Dumitriu, Matthew J Olnes, Phillip Scheinberg, Margaret Bevans, Ankur R Parikh, Kinneret Broder, Katherine R Calvo, Colin O Wu, Neal S Young, Cynthia E Dunbar	Blood	2013
Exome sequencing reveals a thrombopoietin ligand mutation in a Micronesian family with autosomal recessive aplastic anemia Majed J Dasouki, Syed K Rafi, Adam J Olm-Shipman, Nathan R Wilson, Sunil Abhyankar, Brigitte Ganter, L Mike Furness, Jianwen Fang, Rodrigo T Calado, Irfan Saadi	Blood	2013
Preliminary Nonclinical Toxicity, Pharmacokinetics, and Pharmacodynamics of ALXN4100TPO, a Thrombopoietin Receptor Agonist, in CD2F1 Mice M Satyamitra, E Lombardini, T Peng, D Devore, J Graves, C Mullaney, P Ney, V Srinivasan	International Journal of Toxicology	2013
ALERT • Adverse Late Effects of Cancer Treatment: Volume 2: Normal Tissue Specific Sites and Systems P Rubin, LS Constine, LB Marks		2013
Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries C Li, J Li, Y Li, S Lang, I Yougbare, G Zhu, P Chen, H Ni	Advances in Hematology	2012
Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia CL Carmichael, D Metcalf, KJ Henley, EA Kruse, LD Rago, S Mifsud, WS Alexander, BT Kile	Proceedings of the National Academy of Sciences	2012
Novel Pathways to Erythropoiesis Induced by Dimerization of Intracellular C-Mpl in Human Hematopoietic Progenitors C Parekh, A Sahaghian, W Kim, J Scholes, S Ge, Y Zhu, S Asgharzadeh, R Hollis, D Kohn, L Ji, J Malvar, X Wang, G Crooks	Stem Cells	2012
Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential AP Ng, M Kauppi, D Metcalf, LD Rago, CD Hyland, WS Alexander	Proceedings of the National Academy of Sciences	2012
Thrombopoietin as Biomarker and Mediator of Cardiovascular Damage in Critical Diseases E Lupia, A Goffi, O Bosco, G Montrucchio	Mediators of Inflammation	2012
Integrin-αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells T Umemoto, M Yamato, J Ishihara, Y Shiratsuchi, M Utsumi, Y Morita, H Tsukui, M Terasawa, T Shibata, K Nishida, Y Kobayashi, BG Petrich, H Nakauchi, K Eto, T Okano	Blood	2011
Medical Countermeasures for Platelet Regeneration after Radiation Exposure: Report of a Workshop and Guided Discussion Sponsored by the National Institute of Allergy and Infectious Diseases, Bethesda, MD, March 22–23, 2010 AL DiCarlo, M Poncz, DR Cassatt, JR Shah, CW Czarniecki, BW Maidment	Radiation Research	2011
Thrombopoietin and hematopoietic stem cells CA de Graaf, D Metcalf	Cell cycle (Georgetown, Tex.)	2011
Mouse models of diseases of megakaryocyte and platelet homeostasis CL Carmichael, WS Alexander	Mammalian Genome	2011
The PlagL2 transcription factor activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells SF Landrette, D Madera, F He, LH Castilla	Leukemia	2011
G-CSF–mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands A Köhler, KD Filippo, M Hasenberg, C Brandt, E Nye, MP Hosking, TE Lane, L Männ, RM Ransohoff, AE Hauser, O Winter, B Schraven, H Geiger, N Hogg, M Gunzer	Blood	2011
The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour AJ Lilly, WE Johnson, CM Bunce	Stem Cells International	2011
A TPO Receptor Agonist, ALXN4100TPO, Mitigates Radiation-Induced Lethality and Stimulates Hematopoiesis in CD2F1 Mice M Satyamitra, E Lombardini, J Graves, C Mullaney, P Ney, J Hunter, K Johnson, P Tamburini, Y Wang, JP Springhorn, V Srinivasan	Radiation Research	2011
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets EC Josefsson, C James, KJ Henley, MA Debrincat, KL Rogers, MR Dowling, MJ White, EA Kruse, RM Lane, S Ellis, P Nurden, KD Mason, LA O'Reilly, AW Roberts, D Metcalf, DC Huang, BT Kile	Journal of Experimental Medicine	2011
Protective effects on myelosuppression mice treated by three different classic Chinese medicine formulae AB Zhao, B Yu, XL Wu, KJ Cao, EQ Li, QM Li, XY Chen	Pharmacognosy magazine	2011
Orientation-specific signalling by thrombopoietin receptor dimers J Staerk, JP Defour, C Pecquet, E Leroy, H Antoine-Poirel, I Brett, M Itaya, SO Smith, W Vainchenker, SN Constantinescu	The EMBO Journal	2011
Epigenetics: prenatal exposure to genistein leaves a permanent signature on the hematopoietic lineage K Vanhees, S Coort, EJ Ruijters, RW Godschalk, FJ van Schooten, SB van Waalwijk van Doorn-Khosrovani	The FASEB Journal	2011
Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice WS Stevenson, CD Hyland, JG Zhang, PO Morgan, TA Willson, A Gill, AA Hilton, EM Viney, M Bahlo, SL Masters, S Hennebry, SJ Richardson, NA Nicola, D Metcalf, DJ Hilton, AW Roberts, WS Alexander	Proceedings of the National Academy of Sciences	2010
CXCL5 Regulates Chemokine Scavenging and Pulmonary Host Defense to Bacterial Infection J Mei, Y Liu, N Dai, M Favara, T Greene, S Jeyaseelan, M Poncz, JS Lee, GS Worthen	Immunity	2010
Pathophysiology and management of inherited bone marrow failure syndromes A Shimamura, BP Alter	Blood Reviews	2010
Thrombopoietic agents R Stasi, J Bosworth, E Rhodes, MS Shannon, F Willis, EC Gordon-Smith	Blood Reviews	2010
In vitro megakaryocyte production and platelet biogenesis: state of the art JA Reems, N Pineault, S Sun	Transfusion Medicine Reviews	2010
Core Binding Factor at the Crossroads: Determining the Fate of the HSC KA Link, FS Chou, JC Mulloy	Journal of Cellular Physiology	2010
Regulation of hematopoietic stem cells by their mature progeny CA de Graaf, M Kauppi, T Baldwin, CD Hyland, D Metcalf, TA Willson, MR Carpinelli, GK Smyth, WS Alexander, DJ Hilton	Proceedings of the National Academy of Sciences	2010
Congenital amegakaryocytic thrombocytopenia: a brief review of the literature FS Al-Qahtani	Clinical Medicine Insights. Pathology	2010
Gene Therapy of Mpl Deficiency: Challenging Balance Between Leukemia and Pancytopenia DC Wicke, J Meyer, G Buesche, D Heckl, H Kreipe, Z Li, KH Welte, M Ballmaier, C Baum, U Modlich	Molecular Therapy	2009
Increased differentiation of dermal mast cells in mice lacking the Mpl gene B Ghinassi, M Zingariello, F Martelli, R Lorenzini, AM Vannucchi, RA Rana, M Nishikawa, G Migliaccio, J Mascarenhas, AR Migliaccio	Stem Cells and Development	2009
Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage EA Kruse, SJ Loughran, TM Baldwin, EC Josefsson, S Ellis, DK Watson, P Nurden, D Metcalf, DJ Hilton, WS Alexander, BT Kile	Proceedings of the National Academy of Sciences	2009
Thrombopoietin and Platelet Production in Chronic Immune Thrombocytopenia DJ Kuter, TB Gernsheimer	Hematology/Oncology Clinics of North America	2009
Endoreplication: polyploidy with purpose HO Lee, JM Davidson, RJ Duronio	Genes & development	2009
New advances in the treatment of adult chronic immune thrombocytopenic purpura: role of thrombopoietin receptor-stimulating agents A Metjian, CS Abrams	Biologics : targets & therapy	2009
Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia DJ Hilton, BT Kile, WS Alexander	Blood	2009
Congenital Amegakaryocytic Thombocytopenia and Thrombocytopenia with Absent Radii AE Geddis	Hematology/Oncology Clinics of North America	2009
Communication between bone marrow niches in normal bone marrow function and during hemopathies progression S Lamorte, L Remédio, S Dias	Hematology Reviews	2009
An ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominance ER Chan, H Lavender, G Li, P Haviernik, KD Bunting, MD Adams	Experimental Hematology	2008
Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis BJ Lannutti, A Epp, J Roy, J Chen, NC Josephson	Blood	2008
In vitro clinical-grade generation of red blood cells from human umbilical cord blood CD34+ cells EJ Baek, HS Kim, S Kim, H Jin, TY Choi, HO Kim	Transfusion	2008
Thrombopoietin inhibits murine mast cell differentiation F Martelli, B Ghinassi, R Lorenzini, AM Vannucchi, RA Rana, M Nishikawa, S Partamian, G Migliaccio, AR Migliaccio	Stem Cells	2008
Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice M Kauppi, JM Murphy, CA de Graaf, CD Hyland, KT Greig, D Metcalf, AA Hilton, NA Nicola, BT Kile, DJ Hilton, WS Alexander	Blood	2008
Historical review: megakaryopoiesis and thrombopoiesis K Kaushansky	Blood	2007
Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones JL Abkowitz, J Chen	Blood	2007
Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal W Tong, YM Ibarra, HF Lodish	Experimental Hematology	2007
Thrombopoietin Enhances Generation of CD34+ Cells from Human Embryonic Stem Cells AS Srivastava, E Nedelcu, B Esmaeli-Azad, R Mishra, E Carrier	Stem Cells	2007
Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1 D Metcalf, I Majewski, S Mifsud, LD Rago, WS Alexander	Proceedings of the National Academy of Sciences	2007
A New Role of Thrombopoietin Enhancing ex Vivo Expansion of Endothelial Precursor Cells Derived from AC133-positive Cells T Kanayasu-Toyoda, A Ishii-Watabe, T Suzuki, T Oshizawa, T Yamaguchi	The Journal of biological chemistry	2007
Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site Chloé C. Féral, David M. Rose, Jaewon Han, Norma Fox, Gregg J. Silverman, Kenneth Kaushansky, and Mark H. Ginsberg	Journal of Clinical Investigation	2006
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene WS Alexander, EM Viney, JG Zhang, D Metcalf, M Kauppi, CD Hyland, MR Carpinelli, W Stevenson, BA Croker, AA Hilton, S Ellis, C Selan, HH Nandurkar, CC Goodnow, BT Kile, NA Nicola, AW Roberts, DJ Hilton	Proceedings of the National Academy of Sciences	2006
The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells JM Ninos, LC Jefferies, CR Cogle, WG Kerr	Journal of Translational Medicine	2006
Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes KM Pastos, WB Slayton, LM Rimsza, L Young, MC Sola-Visner	Blood	2006
Isolation and characterization of human myeloid progenitor populations—TpoR as discriminator between common myeloid and megakaryocyte/erythroid progenitors L Edvardsson, J Dykes, T Olofsson	Experimental Hematology	2006
A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia IJ Majewski, D Metcalf, LA Mielke, DL Krebs, S Ellis, MR Carpinelli, S Mifsud, LD Rago, J Corbin, NA Nicola, DJ Hilton, WS Alexander	Proceedings of the National Academy of Sciences	2006
The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis J Tober, A Koniski, KE McGrath, R Vemishetti, R Emerson, KK de Mesy-Bentley, R Waugh, J Palis	Blood	2006
Angiotensin II receptor type 1 expression in erythroid progenitors: implications for the pathogenesis of postrenal transplant erythrocytosis M Mrug, BA Julian, JT Prchal	Seminars in Nephrology	2004
Association of single nucleotide polymorphisms in the thrombopoietin-receptor gene, but not the thrombopoietin gene, with differences in platelet count SM Zeng, JC Murray, JA Widness, RG Strauss, J Yankowitz	American Journal of Hematology	2004
Malignant hematopoietic cell lines: in vitro models for the study of erythroleukemia HG Drexler, Y Matsuo, RA MacLeod	Leukemia Research	2004
Lnk Inhibits Tpo–mpl Signaling and Tpo-mediated Megakaryocytopoiesis W Tong, HF Lodish	Journal of Experimental Medicine	2004
Development of hydrocephalus in mice lacking SOCS7 DL Krebs, D Metcalf, TD Merson, AK Voss, T Thomas, JG Zhang, S Rakar, MK O'bryan, TA Willson, EM Viney, LA Mielke, NA Nicola, DJ Hilton, WS Alexander	Proceedings of the National Academy of Sciences	2004
Textbook of Malignant Haematology, Second Edition B Jahagirdar, C Verfaillie	Textbook of Malignant Haematology, Second Edition	2004
Mpl Baltimore: a thrombopoietin receptor polymorphism associated with thrombocytosis AR Moliterno, DM Williams, LI Gutierrez-Alamillo, R Salvatori, RG Ingersoll, JL Spivak	Proceedings of the National Academy of Sciences	2004
Modifier screens in the mouse: time to move forward with reverse genetics DJ Curtis	Proceedings of the National Academy of Sciences	2004
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling MR Carpinelli, DJ Hilton, D Metcalf, JL Antonchuk, CD Hyland, SL Mifsud, LD Rago, AA Hilton, TA Willson, AW Roberts, RG Ramsay, NA Nicola, WS Alexander	Proceedings of the National Academy of Sciences	2004
Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities K Inagaki, T Oda, Y Naka, H Shinkai, N Komatsu, H Iwamura	Blood	2004
Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors J Antonchuk, CD Hyland, DJ Hilton, WS Alexander	Blood	2004
Targeting c-Mpl for Revival of Human Immunodeficiency Virus Type 1-Induced Hematopoietic Inhibition When CD34 + Progenitor Cells Are Re-Engrafted into a Fresh Stromal Microenvironment In Vivo PS Koka, CM Kitchen, ST Reddy	Journal of virology	2004
Thrombopoietin is a major limiting factor for selective outgrowth of human umbilical cord blood cells in non-obese diabetic/severe combined immunodeficient recipient mice MM Verstegen, AW Wognum, G Wagemaker	British Journal of Haematology	2003
Hematopoietic Recovery Following Autologous Bone Marrow Transplantation in a Nonhuman Primate: Effect of Variation in Treatment Schedule with PEG-rHuMGDF AM Farese, TJ MacVittie, L Roskos, RB Stead	Stem Cells	2003
Etiology of the myeloproliferative disorders: the role of thrombopoietin K Kaushansky	Seminars in Hematology	2003
Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol Y Nagata, J Yoshikawa, A Hashimoto, M Yamamoto, AH Payne, K Todokoro	Genes & development	2003
Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs X Xie, RJ Chan, SA Johnson, M Starr, J McCarthy, R Kapur, MC Yoder	Blood	2003
Thrombopoietin (TPO) Expands Hematopoietic Stem Cells (HSCs) Post-transplantation Norma Fox, Greg Priestley, Thalia Papayannopoulou, Kenneth Kaushansky	Journal of Clinical Investigation	2002
Thrombopoietin: from theory to reality K Kaushansky	International Journal of Hematology	2002
The Effect of Thrombopoietin on Erythroid Progenitors in Diamond-Blackfan Anemia H Kawasaki, T Nakano, U Kohdera, Y Kobayashi	International Journal of Hematology	2002
Developmental biology of thrombopoietin in the human fetus and neonate C Dame	Acta Paediatrica	2002
Thrombopoietin: a pan-hematopoietic cytokine AE Geddis, HM Linden, K Kaushansky	Cytokine & Growth Factor Reviews	2002
Zinc Finger Protein, Hzf , Is Required for Megakaryocyte Development and Hemostasis Y Kimura, A Hart, M Hirashima, C Wang, D Holmyard, J Pittman, XL Pang, CW Jackson, A Bernstein	Journal of Experimental Medicine	2002
Mechanisms Leading to Sustained Reversion of β-Thalassemia in Mice by Doxycycline-Controlled Epo Delivery from Muscles S Samakoglu, D Bohl, JM Heard	Molecular Therapy	2002
The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production K Kaushansky, JG Drachman	Oncogene	2002
The Glycan Domain of Thrombopoietin (TPO) Acts in trans to Enhance Secretion of the Hormone and Other Cytokines HM Linden, K Kaushansky	The Journal of biological chemistry	2002
Human Cell Culture MR Koller, BO Palsson, JR Masters		2002
Lineage-specific growth factors can compensate for stem and progenitor cell deficiencies at the postprogenitor cell level: an analysis of doubly TPO- and G-CSF receptor–deficient mice K Kaushansky, N Fox, NL Lin, WC Liles	Blood	2002
The cytoplasmic domain of Mpl receptor transduces exclusive signals in embryonic and fetal hematopoietic cells C Challier, L Cocault, R Berthier, N Binart, I Dusanter-Fourt, G Uzan, M Souyri	Blood	2002
Promegapoietin-1a, an Engineered Chimeric IL-3 and Mpl-L Receptor Agonist, Stimulates Hematopoietic Recovery in Conventional and Abbreviated Schedules Following Radiation-Induced Myelosuppression in Nonhuman Primates AM Farese, WG Smith, JG Giri, N Siegel, JP McKearn, TJ MacVittie	Stem Cells	2001
Repression of AIM-1 Kinase mRNA as Part of a Program of Genes Regulated by Mpl Ligand Y Zhang, S Sun, WC Chen, Y Kaluzhny, D Chinnappan, G Yu, K Ravid	Biochemical and Biophysical Research Communications	2001
Early elevation of serum thrombopoietin levels and subsequent thrombocytosis in healthy preterm infants K Matsubara, K Baba, H Nigami, H Harigaya, A Ishiguro, T Kato, H Miyazaki	British Journal of Haematology	2001
RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes D Yowe, N Weich, M Prabhudas, L Poisson, P Errada, R Kapeller, K Yu, L Faron, M Shen, J Cleary, TM Wilkie, C Gutierrez-Ramos, MR Hodge	Biochemical Journal	2001
Functional analysis of Asb-1 using genetic modification in mice BT Kile, D Metcalf, S Mifsud, L DiRago, NA Nicola, DJ Hilton, WS Alexander	Molecular and cellular biology	2001
Thrombocytopenic c-mpl−/− mice can produce a normal level of platelets after administration of 5-fluorouracil: the effect of age on the response J Levin, L Cocault, C Demerens, C Challier, M Pauchard, J Caen, M Souyri	Blood	2001
Accentuated response to phenylhydrazine and erythropoietin in mice genetically impaired for their GATA-1 expression (GATA-1low mice) AM Vannucchi, L Bianchi, C Cellai, F Paoletti, V Carrai, A Calzolari, L Centurione, R Lorenzini, C Carta, E Alfani, M Sanchez, G Migliaccio, AR Migliaccio	Blood	2001
New insights into the thrombopoietic status of patients on dialysis through the evaluation of megakaryocytopoiesis in bone marrow and of endogenous thrombopoietin levels M Ando, Y Iwamoto, A Suda, K Tsuchiya, H Nihei	Blood	2001
Stem cell generation and choice of fate: role of cytokines and cellular microenvironment SN Constantinescu	Journal of Cellular and Molecular Medicine	2000
Role of thrombopoietin in hematopoietic stem cell and progenitor regulation JG Drachman	Current Opinion in Hematology	2000
Hematopoietic Stem Cell Transplantation C Verfaillie, Y Jiang, R Zhao, F Prosper, R Bhatia	Hematopoietic Stem Cell Transplantation: Role of Facilitating Cells	2000
Hematopoietic Stem Cell Transplantation: Basic Biology and Clinical Effects K Kaushansky, C Begley	Hematopoietic Stem Cell Transplantation: Role of Facilitating Cells	2000
THE SWITCH FROM FETAL TO ADULT ERYTHROPOIESIS C Dame, SE Juul	Clinics in Perinatology	2000
The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-gamma and lacking the SOCS-1 gene D Metcalf, LD Rago, S Mifsud, L Hartley, WS Alexander	Proceedings of the National Academy of Sciences	2000
Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo SM Luoh, E Stefanich, G Solar, H Steinmetz, T Lipari, TI Pestina, CW Jackson, FJ de Sauvage	Molecular and cellular biology	2000
Megakaryocytic Maturation is Regulated by Maintaining a Balance Against Cytokine Induced-cell Proliferation: Steel Factor Retards Thrombopoietin-induced Megakaryocytic Differentiation While Synergistically Stimulating Mitogenesis K Miyazawa, J Nishimaki, T Katagiri, M Yaguchi, O Iwase, A Gotoh, T Tauchi, Y Kawanishi, K Toyama, K Ohyashiki, T Ishibashi, HE Broxmeyer	Hematology	2000
Enhancement of Platelet Recovery After Myelosuppressive Chemotherapy by Recombinant Human Megakaryocyte Growth and Development Factor in Patients With Advanced Cancer RL Basser, C Underhill, I Davis, MD Green, J Cebon, J Zalcberg, J MacMillan, B Cohen, J Marty, RM Fox, CG Begley	Journal of Clinical Oncology	2000
The Glycan Domain of Thrombopoietin Enhances Its Secretion HM Linden, K Kaushansky	Biochemistry	2000
Identification and characterization of a bipotent (erythroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice AM Vannucchi, F Paoletti, S Linari, C Cellai, R Caporale, PR Ferrini, M Sanchez, G Migliaccio, AR Migliaccio	Blood	2000
Expansion of genetically modified primary human hemopoietic cells using chemical inducers of dimerization RE Richard, B Wood, H Zeng, L Jin, T Papayannopoulou, CA Blau	Blood	2000
Physiology and clinical applications of platelet growth factors LA Harker	Current Opinion in Hematology	1999
Thrombopoietin has a differentiative effect on late-stage human erythropoiesis WL Liu, M Wang, DC Tang, I Ding, GP Rodgers	British Journal of Haematology	1999
Thrombopoietin stimulation of hematopoietic stem/progenitor cells MW Long	Current Opinion in Hematology	1999
Thrombopoietin and Hematopoietic Stem Cell Development K Kaushansky	Annals of the New York Academy of Sciences	1999
Effects of recombinant thrombopoietin on the growth of murine primitive and committed hematopoietic progenitors in serum-free culture HI Sasaki, KO Ikuta, TE Funabiki, KE Fujioka, MO Matsuda	Pediatrics International	1999
Human dendritic cells express the thrombopoietin receptor, c-Mpl T Kumamoto, E Azuma, M Tanaka, J Qi, M Hirayama, SL Zhang, M Kobayashi, S Iwamoto, Y Komada, H Yamamoto, K Nakashima, M Sakurai	British Journal of Haematology	1999
Repression of A TAFII32 Isoform as Part of a Program of Genes Regulated during Mpl Ligand-Induced Megakaryocyte Differentiation A Thompson, K Ravid	Biochemical and Biophysical Research Communications	1999
Effects of Megakaryocyte Growth and Development Factor (Thrombopoietin) on Liver Endothelial Cells in Vitro JE Cardier	Microvascular Research	1999
The enigmatic megakaryocyte gradually reveals its secrets K Kaushansky	BioEssays	1999
Thrombopoietin Combined with Early&hyphen;Acting Growth Factors Effectively Expands Human Hematopoietic Progenitor Cells In Vitro JA Hunnestad, R Steen, GE Tjønnfjord, T Egeland	Stem Cells	1999
PEG-rHuMGDF promotes multilineage hematopoietic recovery in myelosuppressed mice TR Ulich, J Castillo, G Senaldi, C Hartley, G Molineux	Experimental Hematology	1999
Thrombopoietin promotes hematopoietic recovery and survival after high-dose whole body irradiation MA Mouthon, AV der Meeren, MH Gaugler, TP Visser, C Squiban, P Gourmelon, G Wagemaker	International journal of radiation oncology, biology, physics	1999
Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia K Ihara, E Ishii, M Eguchi, H Takada, A Suminoe, RA Good, T Hara	Proceedings of the National Academy of Sciences	1999
Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo R Stoffel, S Ziegler, N Ghilardi, B Ledermann, FJ de Sauvage, RC Skoda	Proceedings of the National Academy of Sciences	1999
A mild transient decrease of peripheral red blood cell counts induced by a suprapharmacological dose of pegylated human megakaryocyte growth and development factor in rats K Harada, Y Ide, Y Tazunoki, A Imai, M Yanagida, Y Kikuchi, A Imai, H Ishii, J Kawahara, H Izumi, M Kusaka, T Tokiwa	The Journal of pharmacy and pharmacology	1999
Molecular Biology of Hematopoiesis 6 NG Abraham, A Tabilio, M Martelli, S Asano, A Donfrancesco		1999
Apoptosis and Inflammation JD Winkler		1999
Clinical Applications of Cytokines and Growth Factors JR Wingard, GD Demetri		1999
Recombinant Human Thrombopoietin in Combination With Granulocyte Colony-Stimulating Factor Enhances Mobilization of Peripheral Blood Progenitor Cells, Increases Peripheral Blood Platelet Concentration, and Accelerates Hematopoietic Recovery Following High-Dose Chemotherapy G Somlo, I Sniecinski, A ter Veer, J Longmate, G Knutson, S Vuk-Pavlovic, R Bhatia, W Chow, L Leong, R Morgan, K Margolin, J Raschko, S Shibata, M Tetef, Y Yen, S Forman, D Jones, M Ashby, G Fyfe, S Hellmann, JH Doroshow	Blood	1999
A Randomized, Double-Blind, Placebo-Controlled Study With Pegylated Recombinant Human Megakaryocyte Growth and Development Factor (PEG-rHuMGDF) as an Adjunct to Chemotherapy for Adults With De Novo Acute Myeloid Leukemia E Archimbaud, OG Ottmann, JA Yin, K Lechner, H Dombret, MA Sanz, G Heil, P Fenaux, W Brugger, A Barge, C OBrien-Ewen, J Matcham, D Hoelzer	Blood	1999
Soluble Interleukin-6 (IL-6) Receptor With IL-6 Stimulates Megakaryopoiesis From Human CD34+ Cells Through Glycoprotein (gp)130 Signaling X Sui, K Tsuji, Y Ebihara, R Tanaka, K Muraoka, M Yoshida, K Yamada, K Yasukawa, T Taga, T Kishimoto, T Nakahata	Blood	1999
Serum thrombopoietin levels in haemodialysis patients: involvement of arteriovenous fistula B Altun, M Arici, İC Haznedaroglu, C Usalan, Y Erdem, Ü Yasavul, Ç Turgan, Ş Çaglar, Ş Kirazli	Nephrology Dialysis Transplantation	1999
Hematopoietic growth factors in autologous transplantation GC Avanzi, M Gallicchio, G Saglio	Biotherapy	1998
The Efficacy of Recombinant Thrombopoietin in Murine and Nonhuman Primate Models for Radiation&hyphen;Induced Myelosuppression and Stem Cell Transplantation G Wagemaker, KJ Neelis, SC Hartong, AW Wognum, GR Thomas, PJ Fielder, DL Eaton	Stem Cells	1998
The efficacy of recombinant tpo in murine and nonhuman primate models for myelosuppression and stem cell transplantation G Wagemaker, KJ Neelis, SI Hartong, AW Wognum, GR Thomas, PJ Fielder, DL Eaton	Stem Cells	1998
Further Examination of Various Administration Protocols of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor on Thrombocytopenia in Myelosuppressed Mice H Akahori, M Ozai, M Ida, K Shibuya, T Kato, H Miyazaki	Therapeutic Apheresis and Dialysis	1998
Mpl ligand or thrombopoietin: Biological activities F Wendling, K Cohen-Solal, JL Villeval, N Debili, W Vainchenker	Biotherapy	1998
Myelofibrosis: Experimental models and human studies AL Taskin, K Cohen&hyphen;Solal, JP Couedic, MA Abina, JL Villeval, N Debili, N Casadevall, W Vainchenker, F Wendling	Stem Cells	1998
The role of c&hyphen;Mpl ligands in the expansion of cord blood hematopoietic progenitors W Piacibello, F Sanavio, L Garetto, A Severino, A Danèg, L Gammaitoni, M Aglietta	Stem Cells	1998
Effect of thrombopoietin on proliferation of blasts from CD7-positive acute myelogenous leukaemia Y Tokunaga, T Miyamoto, T Okamura, T Eto, H Gondo, T Kamimura, S Okamura, Y Niho	British Journal of Haematology	1998
Effects of thrombopoietin on the proliferation and differentiation of primitive and mature haemopoietic progenitor cells in cord blood Schipper, Brand, Reniers, Melief, Willemze, Fibbe	British Journal of Haematology	1998
Cytokine gene transfer in cancer therapy L Cao, P Kulmburg, H Veelken, A Mackensen, B Mézes, A Lindemann, R Mertelsmann, FM Rosenthal	Stem Cells	1998
Hematopoietic Deficiencies in c&hyphen;mpl and TPO Knockout Mice M Murone, DA Carpenter, FJ de Sauvage	Stem Cells	1998
Analysis of megakaryocyte growth and development factor (thrombopoietin) effects on blast cell and megakaryocyte growth in myelodysplasia M Fontenay-Roupie, JM Dupont, F Picard, S Fichelson, A Botella, J Melle, M Guesnu, N Casadevall, F Dreyfus, D Bouscary	Leukemia Research	1998
Therapeutic Cytokine Stimulation of Thrombocytopoiesis LA Harker	Transfusion Science	1998
Advances in Protein Chemistry CM Silva, J Isgaard, MO Thorner	Advances in Protein Chemistry	1998
10 Thrombopoietin and its receptor: structure, function and role in the regulation of platelet production AE von Borne, C Folman, GE Linthorst, L Porcelijn, S Oudenrijn, E der Schoot, M Haas	Baillière's Clinical Haematology	1998
Regulation of megakaryocytopoiesis and platelet production: Lessons from animal models FJ de Sauvage, J Villeval, RA Shivdasani	Journal of Laboratory and Clinical Medicine	1998
Quantitative analysis of thrombopoietin receptors on human megakaryocytes T Kuwaki, T Hagiwara, C Yuki, I Kodama, T Kato, H Miyazaki	FEBS Letters	1998
New insights into the regulation of megakaryocyte differentiation and platelet production derived from cloning of thrombopoietin and its receptor: Surprises and unresolved questions as thrombopoietin proceeds through clinical trials CW Jackson	Journal of Laboratory and Clinical Medicine	1998
Lineage commitment in the progeny of murine hematopoietic preprogenitor cells: influence of thrombopoietin and interleukin 5 D Metcalf	Proceedings of the National Academy of Sciences	1998
Thrombopoietin Stimulates Myelodysplastic Syndrome Granulocyte-Macrophage and Erythroid Progenitor Proliferation A Ferrajoli, M Talpaz, R Kurzrock, D Harris, Q Van, EH Estey, Z Estrov	Leukemia & Lymphoma	1998
Thrombocytopenia—Platelet Support or Growth Factors? R Manley, MF Murphy	Hematology	1998
Protein Kinase C Mediates the Mitogenic Action of Thrombopoietin in c-Mpl–Expressing UT-7 Cells Y Hong, D Dumènil, B van der Loo, F Goncalves, W Vainchenker, JD Erusalimsky	Blood	1998
An Agonist Murine Monoclonal Antibody to the Human c-Mpl Receptor Stimulates Megakaryocytopoiesis B Deng, N Banu, B Malloy, P Hass, JF Wang, L Cavacini, D Eaton, H Avraham	Blood	1998
Role of c-mpl in Early Hematopoiesis GP Solar, WG Kerr, FC Zeigler, D Hess, C Donahue, FJ de Sauvage, DL Eaton	Blood	1998
Multilineage Hematopoietic Recovery by a Single Injection of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor in Myelosuppressed Mice K Shibuya, H Akahori, K Takahashi, E Tahara, T Kato, H Miyazaki	Blood	1998
Analysis of c-kit Receptor Dimerization by Fluorescence Resonance Energy Transfer VC Broudy, NL Lin, HJ Bühring, N Komatsu, TJ Kavanagh	Blood	1998
Thrombopoietin and the Hematopoietic Stem Cell K Kaushansky	Blood	1998
Forced GATA-1 Expression in the Murine Myeloid Cell Line M1: Induction of c-Mpl Expression and Megakaryocytic/Erythroid Differentiation Y Yamaguchi, LI Zon, SJ Ackerman, M Yamamoto, T Suda	Blood	1998
A Single Dose of Thrombopoietin Shortly After Myelosuppressive Total Body Irradiation Prevents Pancytopenia in Mice by Promoting Short-Term Multilineage Spleen-Repopulating Cells at the Transient Expense of Bone Marrow–Repopulating Cells KJ Neelis, TP Visser, W Dimjati, GR Thomas, PJ Fielder, D Bloedow, DL Eaton, G Wagemaker	Blood	1998
Thrombopoietin Promotes the Survival of Murine Hematopoietic Long-Term Reconstituting Cells: Comparison With the Effects of FLT3/FLK-2 Ligand and Interleukin-6 T Matsunaga, T Kato, H Miyazaki, M Ogawa	Blood	1998
PEGylation prevents the N-terminal degradation of megakaryocyte growth and development factor P I Guerra, C Acklin, A A Kosky, J M Davis, M J Treuheit, D N Brems	Pharmaceutical Research	1998
Regulation of polymorphonuclear cell activation by thrombopoietin MF Brizzi, E Battaglia, A Rosso, P Strippoli, G Montrucchio, G Camussi, L Pegoraro	Journal of Clinical Investigation	1997
THROMBOPOIETIN: UNDERSTANDING AND MANIPULATING PLATELET PRODUCTION KK MD	Annual Review of Medicine	1997
Thrombopoietin K Kaushansky	Trends in Endocrinology & Metabolism	1997
Mpl Ligand (MGDF) Alone and in Combination with Stem Cell Factor (SCF) Promotes Proliferation and Survival of Human Megakaryocyte, Erythroid and Granulocyte/Macrophage Progenitors JE Rasko, E O'Flaherty, CG Begley	Stem Cells	1997
Thrombopoietin: More than a lineage&hyphen;specific megakaryocyte growth factor K Kaushansky	Stem Cells	1997
Thrombopoietin induces activation of the phosphatidylinositol-3′ kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL M Sattler, R Salgia, MA Durstin, KV Prasad, JD Griffin	Journal of Cellular Physiology	1997
Effects of Recombinant Human Thrombopoietin Alone and in Combination with Erythropoietin and Early&hyphen;Acting Cytokines on Human Mobilized Purified CD34+Progenitor Cells Cultured in Serum&hyphen;Depleted Medium J Birkmann, S Oez, M Smetak, G Kaiser, H Kappauf, WM Gallmeier	Stem Cells	1997
Fetal proteins and chronic treatment with low-dose erythropoietin V Bellizzi, LD Nicola, P Ames, R Libertino, V Terracciano, B Cianciaruso	Journal of Laboratory and Clinical Medicine	1997
Role for C-MPL and its Ligand Thrombopoietin in Early Hematopoiesis N Katayamaa, R Itoh, T Kato, T Sugawara, N Mahmud, K Ohish, M Masuya, M Aoki, N Minami, H Miyazaki, H Shiku	Leukemia & Lymphoma	1997
Cytokines and Growth Factors in Blood Transfusion CT Sibinga, PC Das, B Löwenberg		1997
Thrombopoiesis and Thrombopoietins DJ Kuter, P Hunt, W Sheridan, D Zucker-Franklin		1997
Thrombopoietin Enhances Proliferation and Differentiation of Murine Yolk Sac Erythroid Progenitors T Era, T Takahashi, K Sakai, K Kawamura, T Nakano	Blood	1997
Thrombopoietin Is Synthesized by Bone Marrow Stromal Cells A Guerriero, L Worford, HK Holland, GR Guo, K Sheehan, EK Waller	Blood	1997
Chronic Thrombocytopenia Is Induced in Dogs by Development of Cross-Reacting Antibodies to the MpL Ligand DC Dale, JL Nichol, DA Rich, DM Best, SJ Slichter, W Sheridan, P Hunt	Blood	1997
The Efficacy of Single-Dose Administration of Thrombopoietin With Coadministration of Either Granulocyte/Macrophage or Granulocyte Colony-Stimulating Factor in Myelosuppressed Rhesus Monkeys KJ Neelis, SC Hartong, T Egeland, GR Thomas, DL Eaton, G Wagemaker	Blood	1997
High Thrombopoietin Production by Hematopoietic Cells Induces a Fatal Myeloproliferative Syndrome in Mice JL Villeval, K Cohen-Solal, M Tulliez, S Giraudier, J Guichard, SA Burstein, EM Cramer, W Vainchenker, F Wendling	Blood	1997
In Vitro Development of Erythroid and Megakaryocytic Cells From a UT-7 Subline, UT-7/GM N Komatsu, K Kirito, R Shimizu, M Kunitama, M Yamada, M Uchida, M Takatoku, M Eguchi, Y Miura	Blood	1997
Thrombopoietin Does Not Induce Lineage-Restricted Commitment of Mpl-R Expressing Pluripotent Progenitors But Permits Their Complete Erythroid and Megakaryocytic Differentiation F Goncalves, C Lacout, JL Villeval, F Wendling, W Vainchenker, D Duménil	Blood	1997
Human Platelets Display High-Affinity Receptors for Thrombopoietin VC Broudy, NL Lin, DF Sabath, T Papayannopoulou, K Kaushansky	Blood	1997
Thrombopoietin, a Direct Stimulator of Viability and Multilineage Growth of Primitive Bone Marrow Progenitor Cells SE Jacobsen, OJ Borge, V Ramsfjell, L Cui, JE Cardier, OP Veiby, MJ Murphy, S Lok	Stem Cells	1996
Do the Preclinical Effects of Thrombopoietin Correlate with Its In Vitro Properties? K Kaushansky, VC Broudy, E Sitnicka, C Lofton&hyphen;Day, A Grossman, K Sprugel	Stem Cells	1996
Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor MW Kieran, AC Perkins, SH Orkin, LI Zon	Proceedings of the National Academy of Sciences	1996
Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin F Porteu, MC Rouyez, L Cocault, L Bénit, M Charon, F Picard, S Gisselbrecht, M Souyri, I Dusanter-Fourt	Molecular and cellular biology	1996
In Vivo Biological Effects of Various Forms of Thrombopoietin in a Murine Model of Transient Pancytopenia GR Thomas, H Thibodeaux, CJ Errett, J Mathias, M Marian, G Meng, RL Vandlen, DL Eaton	Stem Cells	1996
Effects of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor on Thrombocytopenia Induced by a New Myelosuppressive Chemotherapy Regimen in Mice H Akahori, K Shibuya, M Ozai, M Ida, K Kabaya, T Kato, H Miyazaki	Stem Cells	1996
In Vivo Effects of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor on Hematopoiesis in Normal Mice K Kabaya, H Akahori, K Shibuya, Y Nitta, M Ida, M Kusaka, T Kato, H Miyazaki	Stem Cells	1996
Thrombopoietin: In vitro predictions, in vivo realities K Kaushansky	American Journal of Hematology	1996
THROMBOPOIETIN: DOES THE IN VITRO BIOLOGY CORRELATE WITH ITS IN VIVO PROPERTIES? K Kaushansky	Vox Sanguinis	1996
Dissection of c&hyphen;Mpl and Thrombopoietin Function: Studies of Knockout Mice and Receptor Signal Transduction AL Gurney, FJ de Sauvage	Stem Cells	1996
Megakaryocytopoiesis In Vitro: From the Stem Cells' Perspective JE Cardier, DC Foster, S Lok, SE Jacobsen, MJ Murphy	Stem Cells	1996
Thrombopoietic Activity of Recombinant Human Interleukin 11 (rHuIL&hyphen;11) in Normal and Myelosuppressed Nonhuman Primates FJ Schlerman, AG Bree, MD Kaviani, SL Nagle, LH Donnelly, LE Mason, RG Schaub, SA Grupp, SJ Goldman	Stem Cells	1996
Thrombopoietin and the physiology of platelet production K Kaushansky	Leukemia Research	1996
Tyrosine-599 of the c-Mpl receptor is required for Shc phosphorylation and the induction of cellular differentiation WS Alexander, AB Maurer, U Novak, M Harrison-Smith	The EMBO Journal	1996
Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells T Gainsford, TA Willson, D Metcalf, E Handman, C McFarlane, A Ng, NA Nicola, WS Alexander, DJ Hilton	Proceedings of the National Academy of Sciences	1996
Megakaryocytes K Kaushansky	Trends in Cardiovascular Medicine	1996

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