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Citations to this article

Apoptosis in rheumatoid arthritis synovium.
G S Firestein, … , M Yeo, N J Zvaifler
G S Firestein, … , M Yeo, N J Zvaifler
Published September 1, 1995
Citation Information: J Clin Invest. 1995;96(3):1631-1638. https://doi.org/10.1172/JCI118202.
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Apoptosis in rheumatoid arthritis synovium.

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Abstract

RA synovial tissue (ST) was studied to determine if and where apoptosis occurs in situ. Genomic DNA was extracted from 5 RA and 1 osteoarthritis ST samples. Agarose gel electrophoresis demonstrated DNA ladders characteristic for apoptosis from each tissue. In situ and labeling (ISEL) was used to identify DNA strand breaks consistent with apoptosis in frozen sections. 12 RA and 4 osteoarthritis ST were studied by ISEL and all were positive, but only 2 of 4 normal tissues were positive. The primary location of apopotic cells was the synovial lining. Some sublining cells were also positive, but lymphoid aggregate staining was conspicuously absent. Immunohistochemistry and ISEL were combined and showed that the lining cells with DNA strand breaks were mainly macrophages, although some fibroblastlike cells were also labeled. Sublining cells with fragmented DNA included macrophages and fibroblasts, but T cells in lymphoid aggregates, which expressed large amounts of bcl-2, were spared. DNA strand breaks in cultured fibroblastlike synoviocytes was assessed using ISEL. Apoptosis could be induced by actinomycin D, anti-fas antibody, IL-1, and TNF-alpha but not by IFN-gamma. Fas expression was also detected on fibroblast-like synoviocytes using flow cytometry. Therefore, DNA strand breaks occur in synovium of patients with arthritis. Cytokines regulate this process, and the cytokine profile in RA (high IL-1/TNF; low IFN-gamma) along with local oxidant injury might favor induction of apoptosis.

Authors

G S Firestein, M Yeo, N J Zvaifler

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Arthritis Research & Therapy 2005
Gene Transfer of Tissue Inhibitor of Metalloproteinases-3 Reverses the Inhibitory Effects of TNF-α on Fas-Induced Apoptosis in Rheumatoid Arthritis Synovial Fibroblasts
A Drynda, PH Quax, M Neumann, WH van der Laan, G Pap, S Drynda, I Meinecke, J Kekow, W Neumann, TW Huizinga, M Naumann, W König, T Pap
Journal of immunology (Baltimore, Md. : 1950) 2005
Reduction of the incidence and severity of collagen-induced arthritis by constitutive Nur77 expression in the T cell lineage
SD Silva, S Han, X Zhang, DP Huston, A Winoto, B Zheng
Arthritis & Rheumatism 2005
Effectiveness of anti-folate receptor β antibody conjugated with truncatedPseudomonas exotoxin in the targeting of rheumatoid arthritis synovial macrophages
R Nagayoshi, T Nagai, K Matsushita, K Sato, N Sunahara, T Matsuda, T Nakamura, S Komiya, M Onda, T Matsuyama
Arthritis & Rheumatism 2005
Anchorage on fibronectin via VLA-5 (alpha5beta1 integrin) protects rheumatoid synovial cells from Fas-induced apoptosis
A Kitagawa, Y Miura, R Saura, M Mitani, H Ishikawa, A Hashiramoto, S Yoshiya, S Shiozawa, M Kurosaka
Annals of the rheumatic diseases 2005
Balance between survivin, a key member of the apoptosis inhibitor family, and its specific antibodies determines erosivity in rheumatoid arthritis
M Bokarewa, S Lindblad, D Bokarew, A Tarkowski
Arthritis Research & Therapy 2005
Synovial fibroblasts in joint destruction of rheumatoid arthritis
CA Seemayer, M Neidhart, A Jüngel, RE Gay, S Gay
Drug Discovery Today: Disease Mechanisms 2005
Fas (CD95)-related apoptosis and rheumatoid arthritis
SL Peng
Rheumatology (Oxford, England) 2005
Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases
M Los, SB Gibson
2005
Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T-cell-mediated spontaneous autoimmune arthritis in mice
Hiroshi Hata, Noriko Sakaguchi, Hiroyuki Yoshitomi, Yoichiroh Iwakura, Kenji Sekikawa, Yoshiaki Azuma, Chieko Kanai, Eiko Moriizumi, Takashi Nomura, Takashi Nakamura, and Shimon Sakaguchi
Journal of Clinical Investigation 2004
The levels of serum-soluble Fas in patients with rheumatoid arthritis and systemic sclerosis
A Ateş, G Kinikli, M Turgay, M Duman
Clinical Rheumatology 2004
Discrepancy between mRNA and protein expression of tumour suppressor maspin in synovial tissue may contribute to synovial hyperplasia in rheumatoid arthritis
J Schedel, O Distler, M Woenckhaus, RE Gay, B Simmen, BA Michel, U Müller-Ladner, S Gay
Annals of the rheumatic diseases 2004
A proinflammatory role for Fas in joints of mice with collagen-induced arthritis
H Tu-Rapp, A Hammermüller, E Mix, HJ Kreutzer, R Goerlich, H Köhler, H Nizze, HJ Thiesen, SM Ibrahim
Arthritis Research & Therapy 2004
Apoptosis in rheumatoid arthritis: friend or foe
H Liu, RM Pope
Rheumatic Disease Clinics of North America 2004
Down-regulation of FLIP sensitizes rheumatoid synovial fibroblasts to Fas-mediated apoptosis
G Palao, B Santiago, M Galindo, M Pay�, JC Ramirez, JL Pablos
Arthritis & Rheumatism 2004
Viruses in Type 1 Diabetes: Brief Review
Y Ji-Won, J Hee-Sook
ILAR journal / National Research Council, Institute of Laboratory Animal Resources 2004
Effects of IL-1β on gene expression in human rheumatoid synovial fibroblasts
JG Jeong, JM Kim, H Cho, W Hahn, SS Yu, S Kim
Biochemical and Biophysical Research Communications 2004
Immunoendocrinology in Health and Disease
N Martens, E Hooghe-Peters, R Hooghe
Immunoendocrinology in Health and Disease 2004
The correlation between monocyte chemoattractant protein-1 and the arthritis of systemic lupus erythematosus among Chinese
DQ Ye, YS Hu, XP Li, SG Yang, JH Hao, F Huang, XJ Zhang
Archives of Dermatological Research 2004
Mycoplasma fermentans inhibits tumor necrosis factor α-induced apoptosis in the human myelomonocytic U937 cell line
M Gerlic, J Horowitz, S Horowitz
Cell Death and Differentiation 2004
Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis
SH Lee, DK Chang, A Goel, CR Boland, W Bugbee, DL Boyle, GS Firestein
Journal of immunology (Baltimore, Md. : 1950) 2003
Activated Protein C Inhibits Proliferation and Tumor Necrosis Factor α–Stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts
Julovi SM, Shen K, McKelvey K, Minhas N, March L, Jackson CJ
Molecular Medicine 2003
Oxidised lipoproteins may promote inflammation through the selective delay of engulfment but not binding of apoptotic cells by macrophages
M Khan, S Pelengaris, M Cooper, C Smith, G Evan, J Betteridge
Atherosclerosis 2003
Apoptosis in rheumatoid arthritis
A Baier, I Meineckel, S Gay, T Pap
Current Opinion in Rheumatology 2003
Expression of Fas antigen and Fas ligand in bronchoalveolar lavage from silicosis patients
A Hamzaoui, J Ammar, H Graïri, K Hamzaoui
Mediators of Inflammation 2003
Synergistic induction of apoptosis of rheumatoid arthritis synovial cells by H2O2 and N-acetyl-leucyl-leucyl-norleucinal
A Akaike, Y Banno, Y Osawa, H Oshita, K Fushimi, H Kodama, K Shimizu
Journal of Orthopaedic Science 2003
Central role of mitochondria and p53 in Fas-mediated apoptosis of rheumatoid synovial fibroblasts
K Itoh, H Hase, H Kojima, K Saotome, K Nishioka, T Kobata
Rheumatology (Oxford, England) 2003
Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium
Q Yao, S Wang, A Gambotto, JC Glorioso, CH Evans, PD Robbins, SC Ghivizzani, TJ Oligino
Gene Therapy 2003
Tumor necrosis factor ? blockade reduces the synovial cell infiltrate early after initiation of treatment, but apparently not by induction of apoptosis in synovial tissue
TJ Smeets, MC Kraan, ME van Loon, PP Tak
Arthritis & Rheumatism 2003
Molekularmedizinische Grundlagen von rheumatischen Erkrankungen
D Ganten, K Ruckpaul, S Gay, JR Kalden
2003
Molecular Mechanisms of Programmed Cell Death
Y Shi, JA Cidlowski, D Scott, JR Wu, YB Shi
2003
Regulation of Joint Destruction and Inflammation by p53 in Collagen-Induced Arthritis
Y Yamanishi, DL Boyle, MJ Pinkoski, A Mahboubi, T Lin, Z Han, NJ Zvaifler, DR Green, GS Firestein
The American Journal of Pathology 2002
Apoptosis as a therapeutic tool in rheumatoid arthritis
RM Pope
Nature Reviews Immunology 2002
Streptococcal Cell Wall Arthritis: Kinetics of Immune Cell Activation in Inflammatory Arthritis
D Kimpel, T Dayton, K Kannan, RE Wolf
Clinical Immunology 2002
Death receptor Fas and autoimmune disease: from the original generation to therapeutic application of agonistic anti-Fas monoclonal antibody
S Yonehara
Cytokine & Growth Factor Reviews 2002
Mediators of inflammation are down-regulated while apoptosis is up-regulated in rheumatoid arthritis synovial tissue by polymerized collagen
J Furuzawa-Carballeda, R Rodríquez-Calderón, LD de León, J Alcocer-Varela
Clinical & Experimental Immunology 2002
Advances in Cell Aging and Gerontology
T Fülöp, K Hirokawa, G Dupuis, A Larbi, G Pawelec
Advances in Cell Aging and Gerontology 2002
p53, proto-oncogene and rheumatoid arthritis
Y Sun, HS Cheung
Seminars in Arthritis and Rheumatism 2002
Constitutive expression of BCL-XL in the T lineage attenuates collagen-induced arthritis in Bcl-XL transgenic mice
Y Chen, E Rosloniec, J Price, M Boothby, J Chen
Arthritis & Rheumatism 2002
Invited Review: Cell Volume Control and Signal Transduction in Apoptosis
M Gómez-Angelats, JA Cidlowski
Toxicologic pathology 2002
FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis
J Schedel, RE Gay, P Kuenzler, C Seemayer, B Simmen, BA Michel, S Gay
Arthritis & Rheumatism 2002
Fibroblast-Like Synoviocytes Support B Cell Pseudoemperipolesis via a Stromal Cell-Derived Factor-1 and CD106 (VCAM-1) Dependent Mechanism
Jan A. Burger, Nathan J. Zvaifler, Nobuhiro Tsukada, Gary S. Firestein, Thomas J. Kipps
Journal of Clinical Investigation 2001
Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation
Q Yao, S Wang, JC Glorioso, CH Evans, PD Robbins, SC Ghivizzani, TJ Oligino
Molecular Therapy 2001
New therapies in development for autoimmune diseases: their rationale for combination treatment
V Strand
Springer Seminars in Immunopathology 2001
Rheumatoid arthritis is more than cytokines: Autoimmunity and rheumatoid arthritis
JS Smolen, G Steiner
Arthritis & Rheumatism 2001
Differential expression pattern of the antiapoptotic proteins, Bcl-2 and FLIP, in experimental arthritis
H Perlman, H Liu, C Georganas, AE Koch, E Shamiyeh, GK Haines, RM Pope
Arthritis & Rheumatism 2001
Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: A possible role in the resolution of arthritis
C Gabay, L Marinova-Mutafchieva, RO Williams, JP Gigley, DM Butler, M Feldmann, WP Arend
Arthritis & Rheumatism 2001
Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasion
T Pap, KR Aupperle, S Gay, GS Firestein, RE Gay
Arthritis & Rheumatism 2001
Signal transduction pathways and apoptosis in bacteria infected chondrocytes
MS Lee, CY Yen, SW Ueng, CH Shih, CC Chao
Journal of Orthopaedic Research 2001
Apoptosis in rheumatoid arthritis - expression of Fas, Fas-L, p53, and Bcl-2 in rheumatoid synovial tissues
CT Chou, JS Yang, MR Lee
The Journal of Pathology 2001
Apoptosis and rheumatoid arthritis: Past, present, and future directions
JD Mountz, HC Hsu, Y Matsuki, HG Zhang
Current Rheumatology Reports 2001
Regulation of rheumatoid synoviocyte proliferation by endogenous p53 induction
K Migita, F Tanaka, S Yamasaki, K Shibatomi, H Ida, A Kawakami, T Aoyagi, Y Kawabe, K Eguchi
Clinical & Experimental Immunology 2001
Nitric oxide protects cultured rheumatoid synovial cells from Fas-induced apoptosis by inhibiting caspase-3
K Migita, S Yamasaki, M Kita, H Ida, K Shibatomi, A Kawakami, T Aoyagi, K Eguchi
Immunology 2001
Nitric oxide and bone
RJ Hof, SH Ralston
Immunology 2001
Importance of NF-kappaB in rheumatoid synovial tissues: in situ NF-kappaB expression and in vitro study using cultured synovial cells
S Yamasaki, A Kawakami, T Nakashima, H Nakamura, M Kamachi, S Honda, Y Hirai, A Hida, H Ida, K Migita, Y Kawabe, T Koji, I Furuichi, T Aoyagi, K Eguchi
Annals of the rheumatic diseases 2001
POTENTIAL BIOLOGIC AGENTS FOR TREATING RHEUMATOID ARTHRITIS
LW Moreland
Rheumatic Disease Clinics of North America 2001
Cigarette smoking and rheumatoid arthritis
SA Albano, E Santana-Sahagun, MH Weisman
Seminars in Arthritis and Rheumatism 2001
Suppression of arthritis by forced expression of cyclin-dependent kinase inhibitor p21Cip1 gene into the joints
Y Nonomura, H Kohsaka, K Nasu, Y Terada, M Ikeda, N Miyasaka
International Immunology 2001
Alterations of Fas (APO-1/CD 95) gene and its relationship with p53 in non small cell lung cancer
L Boldrini, P Faviana, F Pistolesi, S Gisfredi, DD Quirico, M Lucchi, A Mussi, CA Angeletti, F Baldinotti, A Fogli, P Simi, F Basolo, G Fontanini
Oncogene 2001
Pathogenesis of arthritis: recent research progress
M Feldmann
Nature Immunology 2001
CD44 Is the Physiological Trigger of Fas Up-Regulation on Rheumatoid Synovial Cells
K Fujii, Y Fujii, S Hubscher, Y Tanaka
Journal of immunology (Baltimore, Md. : 1950) 2001
Apoptosis in interface membranes of aseptically loose total hip arthroplasty
O L Huk, D J Zukor, W Ralston, A Lisbona, A Petit
Journal of Materials Science: Materials in Medicine 2001
Immune modulatory potentials of antineoplaston A-10 in breast cancer patients
F Badria
Cancer Letters 2000
Apoptosis in parathyroid hyperplasia of patients with primary or secondary uremic hyperparathyroidism
P Zhang, P Duchambon, J Gogusev, B Nabarra, E Sarfati, A Bourdeau, TB Drüeke
Kidney International 2000
Induction of apoptosis during development of hypertensive nephrosclerosis1
WZ Ying, PX Wang, PW Sanders
Kidney International 2000
Differential Roles of Fas Ligand in Spontaneous and Actively Induced Autoimmune Encephalomyelitis
TS Liu, B Hilliard, EB Samoilova, Y Chen
Clinical Immunology 2000
Adenoviral mediated delivery of FAS ligand to arthritic joints causes extensive apoptosis in the synovial lining
Q Yao, JC Glorioso, CH Evans, PD Robbins, I Kovesdi, TJ Oligino, SC Ghivizzani
The Journal of Gene Medicine 2000
TUMOUR NECROSIS FACTOR α (TNF-α) INTERFERES WITH Fas-MEDIATED APOPTOTIC CELL DEATH ON RHEUMATOID ARTHRITIS (RA) SYNOVIAL CELLS: A POSSIBLE MECHANISM OF RHEUMATOID SYNOVIAL HYPERPLASIA AND A CLINICAL BENEFIT OF ANTI-TNF-α THERAPY FOR RA
S Ohshima
Cytokine 2000
Cloning and Expression of a Novel Murine Anti-human Fas Antibody
H YOSHIDA-KATO, K ICHIKAWA, J YAMAGUCHI, K WATANABE, J OHSUMI, S YONEHARA, N SERIZAWA
Bioscience, Biotechnology, and Biochemistry 2000
Molecular mechanism of monocyte predominant infiltration in chronic inflammation: Mediation by a novel monocyte chemotactic factor, S19 ribosomal protein dimer
T Yamamoto
Pathology International 2000
The pathogenesis and prevention of joint damage in rheumatoid arthritis: Advances from synovial biopsy and tissue analysis
PP Tak, B Bresnihan
Arthritis & Rheumatism 2000
Synovial biopsy in arthritis research: five years of concerted European collaboration
B Bresnihan, PP Tak, P Emery, L Klareskog, F Breedveld
Annals of the rheumatic diseases 2000
Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis
T Pap, U Müller-Ladner, RE Gay, S Gay
Arthritis research 2000
Apoptosis in normal and osteoarthritic human articular cartilage
F Héraud, A Héraud, MF Harmand
Annals of the rheumatic diseases 2000
Comparative study of the synovial histology in rheumatoid arthritis, spondyloarthropathy, and osteoarthritis: influence of disease duration and activity
D Baeten, P Demetter, C Cuvelier, FV Bosch, E Kruithof, NV Damme, G Verbruggen, H Mielants, EM Veys, FD Keyser
Annals of the rheumatic diseases 2000
Nuclear factor-kappaB and caspases co-operatively regulate the activation and apoptosis of human macrophages
A Hida, A Kawakami, T Nakashima, S Yamasaki, H Sakai, S Urayama, H Ida, H Nakamura, K Migita, Y Kawabe, K Eguchi
Immunology 2000
Apoptosis and p53 expression in rat adjuvant arthritis
PP Tak, MS Klapwijk, SF Broersen, DA van de Geest, M Overbeek, GS Firestein
Arthritis research 2000
Nitric oxide is a mediator of apoptosis in the rheumatoid joint
RJ Hof, L Hocking, PK Wright, SH Ralston
Rheumatology 2000
Apoptosis in rheumatic diseases
T Grodzicky, KB Elkon
The American Journal of Medicine 2000
Novel gene therapy for rheumatoid arthritis by FADD gene transfer: induction of apoptosis of rheumatoid synoviocytes but not chondrocytes
T Kobayashi, K Okamoto, T Kobata, T Hasunuma, T Kato, H Hamada, K Nishioka
Gene Therapy 2000
Rheumatoid arthritis synovial stromal cells inhibit apoptosis and up-regulate Bcl-xL expression by B cells in a CD49/CD29-CD106-dependent mechanism
K Hayashida, Y Shimaoka, T Ochi, PE Lipsky
Journal of immunology (Baltimore, Md. : 1950) 2000
A novel murine anti-human Fas mAb which mitigates lymphadenopathy without hepatotoxicity
K Ichikawa, H Yoshida-Kato, M Ohtsuki, J Ohsumi, J Yamaguchi, S Takahashi, Y Tani, M Watanabe, A Shiraishi, K Nishioka, S Yonehara, N Serizawa
International Immunology 2000
Regulation of Rheumatoid Synovial Cell Growth by Ceramide
K Migita, S Honda, S Yamasaki, Y Hirai, T Fukuda, T Aoyagi, M Kita, H Ida, T Tsukada, A Kawakami, Y Kawabe, K Eguchi
Biochemical and Biophysical Research Communications 2000
Nicotine switches the form of H2O2-induced cell death from apoptosis to necrosis in U937 cells
N Sugano, K Ito
Immunology Letters 2000
C-Reactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains an Antiinflammatory Innate Immune Response: Implications for Systemic Autoimmunity
D Gershov, SJ Kim, N Brot, KB Elkon
Journal of Experimental Medicine 2000
Fas‐associated death domain protein is a Fas‐mediated apoptosis modulator in synoviocytes
K Okamoto, T Kobayashi, T Kobata, T Hasunuma, T Kato, T Sumida, K Nishioka
Rheumatology (Oxford, England) 2000
Gelenkpathologie
W Mohr
2000
Stromal Cell-Derived Factor-1-CXC Chemokine Receptor 4 Interactions Play a Central Role in CD4 + T Cell Accumulation in Rheumatoid Arthritis Synovium
T Nanki, K Hayashida, HS El-Gabalawy, S Suson, K Shi, HJ Girschick, S Yavuz, PE Lipsky
Journal of immunology (Baltimore, Md. : 1950) 2000
p53 in rheumatoid arthritis: friend or foe?
Müller-Ladner U, Nishioka K
Arthritis research 2000
p53 in rheumatoid arthritis: friend or foe?
Müller-Ladner U, Nishioka K
Arthritis research 2000
Starving the synovium: angiogenesis and inflammation in rheumatoid arthritis
GS Firestein
Journal of Clinical Investigation 1999
Macrophages as Effectors of the Immunoendocrinologic Interactions in Autoimmune Rheumatic Diseasesa
M Cutolo
Annals of the New York Academy of Sciences 1999
Apoptosis in Human Autoimmune Diseases
CT Ravirajan, V Pittoni, DA Isenberg
International Reviews of Immunology 1999
β1-Integrin–collagen interaction reduces chondrocyte apoptosis
L Cao, V Lee, ME Adams, C Kiani, Y Zhang, W Hu, BB Yang
Matrix Biology 1999
Update Rheumatologie
G Hein, P Oelzner, H Sprott, B Manger
Medizinische Klinik 1999
Activation-induced apoptosis of autoreactive and alloreactive T lymphocytes in the target organ as a major mechanism of tolerance
MP Pender
Immunology and Cell Biology 1999
Apomodulation as a novel therapeutic concept for the regulation of apoptosis in rheumatoid synoviocytes
T Kobayashi, K Okamoto, T Kobata, T Hasumuna, K Nishioka
Current Opinion in Rheumatology 1999
Current perspectives on synovitis
PP Tak, FC Breedveld
Arthritis research 1999
The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)
PP Tak, L Spaeny-Dekking, MC Kraan, FC Breedveld, CJ Froelich, CE Hack
Clinical & Experimental Immunology 1999
Cyclosporin A inhibits H2O2-induced apoptosis of human fibroblasts
N Sugano, K Ito, S Murai
FEBS Letters 1999
Chondrocyte apoptosis induced by aggrecan G1 domain as a result of decreased cell adhesion
L Cao, BB Yang
Experimental Cell Research 1999
Tumor necrosis factor-α and interleukin-1β increase the Fas-mediated apoptosis of human osteoblasts
M Tsuboi, A Kawakami, T Nakashima, N Matsuoka, S Urayama, Y Kawabe, K Fujiyama, T Kiriyama, T Aoyagi, K Maeda, K Eguchi
Journal of Laboratory and Clinical Medicine 1999
Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis
K Taniguchi, H Kohsaka, N Inoue, Y Terada, H Ito, K Hirokawa, N Miyasaka
Nature Medicine 1999
C-MYC antisense oligodeoxynucleotides can induce apoptosis and down-regulate Fas expression in rheumatoid synoviocytes
A Hashiramoto, H Sano, T Maekawa, Y Kawahito, S Kimura, Y Kusaka, RL Wilder, H Kato, M Kondo, H Nakajima
Arthritis & Rheumatism 1999
Fas and Fas ligand interaction induces apoptosis in inflammatory myopathies: CD4+ T cells cause muscle cell injury directly in polymyositis
T Sugiura, Y Murakawa, A Nagai, M Kondo, S Kobayashi
Arthritis & Rheumatism 1999
Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue
J Hamann, JO Wishaupt, RA van Lier, TJ Smeets, FC Breedveld, PP Tak
Arthritis & Rheumatism 1999
P53 overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis
PP Tak, TJ Smeets, DL Boyle, MC Kraan, Y Shi, S Zhuang, NJ Zvaifler, FC Breedveld, GS Firestein
Arthritis & Rheumatism 1999
Regulation of synovial cell apoptosis by proteasome inhibitor
A Kawakami, T Nakashima, H Sakai, A Hida, S Urayama, S Yamasaki, H Nakamura, H Ida, Y Ichinose, T Aoyagi, I Furuichi, M Nakashima, K Migita, Y Kawabe, K Eguchi
Arthritis & Rheumatism 1999
New therapeutic targets for rheumatoid arthritis
H J Dinant, B A Dijkmans
Pharmacy World & Science 1999
Update Rheumatologie: Kenntnisstand zur Ätiopathogenese, Diagnostik und Therapie ausgewählter Arthritisformen Teil I: Ätiopathogenese und Diagnostik
G Hein, P Oelzner, H Sprott, B Manger
Medizinische Klinik 1999
Synovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritis
JL Funk, LA Cordaro, H Wei, JB Benjamin, DE Yocum
Journal of Clinical Investigation 1998
Anti-fas induces apoptosis and proliferation in human dermal fibroblasts: Differences between foreskin and adult fibroblasts
A Jelaska, JH Korn
Journal of Cellular Physiology 1998
Molecular Lysis of Synovial Lining Cells byIn VivoHerpes Simplex Virus-Thymidine Kinase Gene Transfer
SM Sant, TM Suarez, MR Moalli, BY Wu, M Blaivas, TJ Laing, BJ Roessler
Human Gene Therapy 1998
CD28 co-stimulation is intact and contributes to prolongedex vivo survival of hyporesponsive synovial fluid T cells in rheumatoid arthritis
MM Maurice, EA van der Voort, A Leow, N Levarht, FC Breedveld, CL Verweij
European Journal of Immunology 1998
Molecular mechanism of immune response, synovial proliferation and apoptosis in rheumatoid arthritis
T Hasunuma, T Kato, T Kobata, K Nishioka
Springer Seminars in Immunopathology 1998
Effects of 2-Chlorodeoxyadenosine and Gold Sodium Thiomalate on Human bcl-2 Gene Expression
PP Sfikakis, MA Dimopoulos, VL Souliotis, D Charalambopoulos, M Mavrikakis, P Panayiotidis
Immunopharmacology and Immunotoxicology 1998
CD4+ T-cell-mediated cytotoxicity against staphylococcal enterotoxin B-pulsed synovial cells
KAWAKAMI, MATSUOKA, TSUBOI, URAYAMA, NAKASHIMA, KAWABE, KOJI, AOYAGI, MAEDA, EGUCHI
Immunology 1998
Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis
H Hashimoto, M Tanaka, T Suda, T Tomita, K Hayashida, E Takeuchi, M Kaneko, H Takano, S Nagata, T Ochi
Arthritis & Rheumatism 1998
Amelioration of antigen-induced arthritis in rabbits by induction of apoptosis of inflammatory-cells with local application of transdermal photodynamic therapy
LG Ratkay, RK Chowdhary, A Iamaroon, AM Richter, HC Neyndorff, EC Keystone, JD Waterfield, JG Levy
Arthritis & Rheumatism 1998
Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes
M Seitz, M Zwicker, P Loetscher
Arthritis & Rheumatism 1998
Cutaneous allergic vasculitis: Clinicopathological characterization and identification of apoptosis
Y Shi, M Honma, F Koizumi
Pathology International 1998
Retroviral Sequences in Rheumatoid Arthritis Synovium
U Müller-Ladner, RE Gay, S Gay
International Reviews of Immunology 1998
Focally regulated endothelial proliferation and cell death in human synovium
DA Walsh, M Wade, PI Mapp, DR Blake
The American Journal of Pathology 1998
Modulation by proinflammatory cytokines of Fas/Fas ligand-mediated apoptotic cell death of synovial cells in patients with rheumatoid arthritis (RA)
S Wakisaka, N Suzuki, Y Takeba, Y Shimoyama, H Nagafuchi, M Takeno, N Saito, T Yokoe, A Kaneko, T Asai, T Sakane
Clinical & Experimental Immunology 1998
Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene
KR Aupperle, DL Boyle, M Hendrix, EA Seftor, NJ Zvaifler, M Barbosa, GS Firestein
The American Journal of Pathology 1998
Synovial fibroblasts and the sphingomyelinase pathway: sphingomyelin turnover and ceramide generation are not signaling mechanisms for the actions of tumor necrosis factor-alpha
ME Gerritsen, CP Shen, CA Perry
The American Journal of Pathology 1998
NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint
AV Miagkov, DV Kovalenko, CE Brown, JR Didsbury, JP Cogswell, SA Stimpson, AS Baldwin, SS Makarov
Proceedings of the National Academy of Sciences 1998
Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha, as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells
N Mizushima, H Kohsaka, N Miyasaka
Annals of the rheumatic diseases 1998
BIOLOGIC AGENTS AND IMMUNOTHERAPY IN RHEUMATOID ARTHRITIS
WJ Wallis, DE Furst, V Strand, E Keystone
Rheumatic Disease Clinics of North America 1998
NF- B activation provides the potential link between inflammation and hyperplasia in the arthritic joint
AV Miagkov, DV Kovalenko, CE Brown, JR Didsbury, JP Cogswell, SA Stimpson, AS Baldwin, SS Makarov
Proceedings of the National Academy of Sciences 1998
Apoptosis induction in synovial fibroblasts by ceramide: In vitro and in vivo effects
Y Ichinose, K Eguchi, K Migita, Y Kawabe, T Tsukada, T Koji, K Abe, T Aoyagi, H Nakamura, S Nagataki
Journal of Laboratory and Clinical Medicine 1998
p53 and p21WAF1Expression in Lymphocytic Thyroiditis and Thyroid Tumors
I Okayasu, T Osakabe, M Onozawa, T Mikami, M Fujiwara
Clinical Immunology and Immunopathology 1998
Inhibitory Effect of Glucocorticoid for Osteoblast Apoptosis Induced by Activated Peripheral Blood Mononuclear Cells
T Nakashima, H Sasaki, M Tsuboi, A Kawakami, K Fujiyama, T Kiriyama, K Eguchi, M Ichikawa, S Nagataki
Endocrinology 1998
Synovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritis
JL Funk, LA Cordaro, H Wei, JB Benjamin, DE Yocum
Reproductive sciences (Thousand Oaks, Calif.) 1998
Pathogenic mechanisms in the rheumatoid nodule: Comparison of proinflammatory cytokine production and cell adhesion molecule expression in rheumatoid nodules and synovial membranes from the same patient
R Wikaningrum, J Highton, A Parker, M Coleman, PA Hessian, PJ Roberts-Thomson, MJ Ahern, MD Smith
Arthritis & Rheumatism 1998
T Cells in Arthritis
P Miossec, GS Firestein, WB van den Berg
1998
CD4+ T-cell-mediated cytotoxicity against staphylococcal enterotoxin B-pulsed synovial cells.
Kawakami A, Matsuoka N, Tsuboi M, Urayama S, Nakashima T, Kawabe Y, Koji T, Aoyagi T, Maeda K, Eguchi K
Immunology 1998
Inhibition of T cell apoptosis in the rheumatoid synovium
M Salmon, D Scheel-Toellner, AP Huissoon, D Pilling, N Shamsadeen, H Hyde, AD D'Angeac, PA Bacon, P Emery, AN Akbar
Journal of Clinical Investigation 1997
Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer
H Zhang, Y Yang, JL Horton, EB Samoilova, TA Judge, LA Turka, JM Wilson, Y Chen
Journal of Clinical Investigation 1997
Soluble oligonucleosomal complexes in synovial fluid from inflamed joints
D Yu, PM Rumore, Q Liu, CR Steinman
Arthritis & Rheumatism 1997
Fas and Fas Ligand Interaction Is Necessary for Human Osteoblast Apoptosis
A Kawakami, K Eguchi, N Matsuoka, M Tsuboi, T Koji, S Urayama, K Fujiyama, T Kiriyama, T Nakashima, PK Nakane, S Nagataki
Journal of Bone and Mineral Research 1997
Apoptosis in the rheumatic diseases
AK Vaishnaw, JD McNally, KB Elkon
Arthritis & Rheumatism 1997
Fas andFas ligand expression in the salivary glands of patients with primary Sjögren's syndrome
L Kong, N Ogawa, T Nakabayashi, GT Liu, E D'Souza, HS McGuff, D Guerrero, N Talal, H Dang
Arthritis & Rheumatism 1997
Fushi-ka (defective apoptosis) and rheumatic autoimmune diseases: an overview on the regulation of Fas-mediated T cell apoptotic signal transduction
KM Sakata, A Sakata, L Kong, T Nakabayashi, N Ogawa, H Dang, N Talal
Japanese Journal of Rheumatology 1997
In Situ hybridization and its diagnostic applications in pathology
AM McNicol, MA Farquharson
The Journal of Pathology 1997
Paclitaxel selectively induces mitotic arrest and apoptosis in proliferating bovine synoviocytes
A Hui, GV Kulkarni, WL Hunter, CA McCulloch, TF Cruz
Arthritis & Rheumatism 1997
Selective activation of the JNK/AP-1 pathway in FAS-mediated apoptosis of rheumatoid arthritis synoviocytes
K Okamoto, K Fujisawa, T Hasunuma, T Kobata, T Sumida, K Nishioka
Arthritis & Rheumatism 1997
Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis
MJ Cantwell, T Hua, NJ Zvaifler, TJ Kipps
Arthritis & Rheumatism 1997
FAS/FAS ligand expression and induction of apoptosis in chondrocytes
S Hashimoto, M Setareh, RL Ochs, M Lotz
Arthritis & Rheumatism 1997
Accumulation of soluble fas in inflamed joints of patients with rheumatoid arthritis
T Hasunuma, N Kayagaki, H Asahara, S Motokawa, T Kobata, H Yagita, H Aono, T Sumida, K Okumura, K Nishioka
Arthritis & Rheumatism 1997
Generation of reactive oxygen species is required for bucillamine, a novel anti-rheumatic drug, to induce apoptosis in concert with copper
T Sawada, S Hashimoto, H Furukawa, S Tohma, T Inoue, K Ito
Immunopharmacology 1997
Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium
GS Firestein, F Echeverri, M Yeo, NJ Zvaifler, DR Green
Proceedings of the National Academy of Sciences 1997
Interleukin-10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl-2
SB Cohen, JB Crawley, MC Kahan, M Feldmann, BM Foxwell
Immunology 1997
Detection of p53 in inflammatory tissue and lymphocytes using immunohistology and flow cytometry: a critical comment
A Nickels, H Selter, M Pfreundschuh, M Montenarh, B Koch
Journal of clinical pathology 1997
Fas receptor is expressed in human lung squamous cell carcinomas, whereas bcl-2 and apoptosis are not pronounced: a preliminary report
HB Hellquist, B Olejnicka, M Jadner, T Andersson, C Sederholm
British Journal of Cancer 1997
Do sex hormones modulate the synovial macrophages in rheumatoid arthritis?
M Cutolo
Annals of the rheumatic diseases 1997
Gene therapy for arthritis
CH Evans, PD Robbins
Expert Opinion on Investigational Drugs 1997
Metallothionein and Fas (CD95) are expressed in squamous cell carcinoma of the tongue
K Sundelin, M Jadner, L Norberg-Spaak, A Davidsson, HB Hellquist
European Journal of Cancer 1997
Fas/Fas Ligand Interaction Regulates Cytotoxicity of CD4+T Cells against Staphylococcal Enterotoxin B-Pulsed Endothelial Cells
S Urayama, A Kawakami, N Matsuoka, M Tsuboi, T Nakashima, Y Kawabe, T Koji, K Eguchi
Biochemical and Biophysical Research Communications 1997
What Does Cell Death Have To Do with Aging?
HR Warner, RJ Hodes, K Pocinki
Journal of the American Geriatrics Society 1997
T-cells in the pathogenesis of rheumatoid arthritis villains or accomplices?
R W Kinne, E Palombo-Kinne, F Emmrich
Biochimica et Biophysica Acta 1997
Drug-Induced Autoimmunity and Autoimmune Disease
N Talal, H Dang
Drug Information Journal 1997
Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice
K Fujisawa, H Asahara, K Okamoto, H Aono, T Hasunuma, T Kobata, Y Iwakura, S Yonehara, T Sumida, K Nishioka
Journal of Clinical Investigation 1996
Evaluation of the BCL-2 gene locus as a susceptibility locus linked to the clinical expression of systemic lupus erythematosus (SLE)
QR Huang, D Morris, N Manolios
Rheumatology International 1996
Perturbations of hypothalamic-pituitary-gonadal (HPG) axis and adrenal androgen (AA) functions in rheumatoid arthritis
AT Masi, JA da Silva, M Cutolo
Baillière's Clinical Rheumatology 1996
Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?
GS Firestein
Arthritis & Rheumatism 1996
Fetal growth retardation in rats may result from apoptosis: Role of peroxynitrite
MJ Miller, CA Voelker, S Olister, JH Thompson, XJ Zhang, D Rivera, S Eloby-childress, X Liu, DA Clark, MR Pierce
Free radical biology & medicine 1996
Inhibition of fas antigen-mediated apoptosis of rheumatoid synovial cells in vitro by transforming growth factor β1
A Kawakami, K Eguchi, N Matsuoka, M Tsuboi, Y Kawabe, T Aoyagi, S Nagataki
Arthritis & Rheumatism 1996
Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium
GS Firestein, K Nguyen, KR Aupperle, M Yeo, DL Boyle, NJ Zvaifler
The American Journal of Pathology 1996
Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice
U Müller-Ladner, J Kriegsmann, BN Franklin, S Matsumoto, T Geiler, RE Gay, S Gay
The American Journal of Pathology 1996
A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis
S Albani, DA Carson
Immunology Today 1996
The calpain-calpastatin system in rheumatoid arthritis
HA Ménard, M El-Amine
Immunology Today 1996
Reactive Oxygen Species Mediate Cytokine Activation of c-Jun NH 2 -terminal Kinases
YY Lo, JM Wong, TF Cruz
The Journal of biological chemistry 1996
Localisation of apoptosis and expression of apoptosis related proteins in the synovium of patients with rheumatoid arthritis
M Sugiyama, T Tsukazaki, A Yonekura, S Matsuzaki, S Yamashita, K Iwasaki
Annals of the rheumatic diseases 1996
Analysis of bcl-2+ lymphocyte subpopulations in inflammatory synovial infiltrates by a double-immunostaining technique.
Zdichavsky M, Schorpp C, Nickels A, Koch B, Pfreundschuh M, Gause A
Rheumatology International 1996
Arthritis Research
CB Favour, RE Ritts, TB Bayles
New England Journal of Medicine 1956

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