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Citations to this article

Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.
S K Moestrup, … , J Gliemann, E I Christensen
S K Moestrup, … , J Gliemann, E I Christensen
Published September 1, 1995
Citation Information: J Clin Invest. 1995;96(3):1404-1413. https://doi.org/10.1172/JCI118176.
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Research Article Article has an altmetric score of 12

Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.

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Abstract

Authors

S K Moestrup, S Cui, H Vorum, C Bregengård, S E Bjørn, K Norris, J Gliemann, E I Christensen

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Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1991 Total
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Citations to this article (267)

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M Vaara
Current Opinion in Microbiology 2010
Molecular-targeted approaches to reduce renal accumulation of nephrotoxic drugs
J Nagai, M Takano
Expert Opinion on Drug Metabolism & Toxicology 2010
Identification of genes involved in gentamicin-induced nephrotoxicity in rats – A toxicogenomic investigation
N Ozaki, KA Matheis, M Gamber, T Feidl, T Nolte, A Kalkuhl, U Deschl
Experimental and Toxicologic Pathology 2010
Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells
DJ Antoine, A Srivastava, M Pirmohamed, BK Park
Biochemical Pharmacology 2010
Comprehensive Toxicology
JM Sands, JW Verlander
Comprehensive Toxicology 2010
Renoprotective effects of paricalcitol on gentamicin-induced kidney injury in rats
JW Park, EH Bae, IJ Kim, SK Ma, C Choi, JU Lee, SW Kim
American journal of physiology. Renal physiology 2010
Functional Ultrastructure
M Pavelka, J Roth
2010
Designing functional foods
CM Lo, P Tso
Designing functional foods 2009
Poly-L-aspartic acid enhances and prolongs gentamicin-mediated suppression of the CFTR-G542X mutation in a cystic fibrosis mouse model
M Du, KM Keeling, L Fan, X Liu, DM Bedwell
The Journal of biological chemistry 2009
Lipopeptides as anti-infectives: a practical perspective
G Pirri, A Giuliani, SF Nicoletto, L Pizzuto, AC Rinaldi
Central European Journal of Biology 2009
Receptor-mediated therapeutic transport across the blood–brain barrier
YY Wang, PC Lui, JY Li
Immunotherapy 2009
Disruption of gap junctional intercellular communication by antibiotic gentamicin is associated with aberrant localization of occludin, N-cadherin, connexin 43, and vimentin in SerW3 Sertoli cells in vitro
SH Bekheet, R Stahlmann
Environmental Toxicology and Pharmacology 2009
Poly-l-aspartic Acid Enhances and Prolongs Gentamicin-mediated Suppression of the CFTR -G542X Mutation in a Cystic Fibrosis Mouse Model
M Du, KM Keeling, L Fan, X Liu, DM Bedwell
The Journal of biological chemistry 2009
Drug Delivery to the Central Nervous System
KK Jain
2009
Effect of PEGylation of N-WASP181-200 on the Inhibitory Potency for Renal Aminoglycoside Accumulation
K Fujii, J Nagai, T Sawada, R Yumoto, M Takano
Bioconjugate Chemistry 2009
Cystic fibrosis, aminoglycoside treatment and acute renal failure: the not so gentle micin
D Bockenhauer, MJ Hug, R Kleta
Pediatric Nephrology 2009
Calcium-sensing receptor antagonism or lithium treatment ameliorates aminoglycoside-induced cell death in renal epithelial cells
CE Gibbons, D Maldonado-Pérez, AN Shah, D Riccardi, DT Ward
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2008
Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery
KM Wasan, DR Brocks, SD Lee, K Sachs-Barrable, SJ Thornton
Nature Reviews Drug Discovery 2008
Gene expression analysis defines the proximal tubule as the compartment for endocytic receptor-mediated uptake in the Xenopus pronephric kidney
EI Christensen, D Raciti, L Reggiani, PJ Verroust, AW Brändli
Pflügers Archiv - European Journal of Physiology 2008
Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2
M Demeule, JC Currie, Y Bertrand, C Ché, T Nguyen, A Régina, R Gabathuler, JP Castaigne, R Béliveau
Journal of Neurochemistry 2008
Increased Incidence of Acute Kidney Injury with Aprotinin Use during Cardiac Surgery Detected with Urinary NGAL
G Wagener, G Gubitosa, S Wang, N Borregaard, M Kim, HT Lee
American Journal of Nephrology 2008
Comprehensive Pediatric Nephrology
R Gbadegesin, WE Smoyer
Comprehensive Pediatric Nephrology 2008
A megalin-like receptor is involved in protein endocytosis in the midgut of an insect ( Bombyx mori , Lepidoptera)
M Casartelli, G Cermenati, S Rodighiero, F Pennacchio, B Giordana
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2008
hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics
M Wieser, G Stadler, P Jennings, B Streubel, W Pfaller, P Ambros, C Riedl, H Katinger, J Grillari, R Grillari-Voglauer
American journal of physiology. Renal physiology 2008
Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss
O König, L Rüttiger, M Müller, U Zimmermann, B Erdmann, H Kalbacher, M Gross, M Knipper
The FASEB Journal 2008
Specific Renal Uptake of Randomly 50% N -Acetylated Low Molecular Weight Chitosan
Z Yuan, Z Zhang, D Zhu, X Sun, T Gong, J Liu, C Luan
Molecular Pharmaceutics 2008
Clinical Nephrotoxins
ME Broe, GA Porter, WM Bennett, G Deray
2008
Auditory Trauma, Protection, and Repair
J Schacht, AN Popper, RR Fay
2008
Reducing Renal Uptake of Radiolabeled Peptides Using Albumin Fragments
E Vegt, JE van Eerd, A Eek, WJ Oyen, JF Wetzels, M de Jong, FG Russel, R Masereeuw, M Gotthardt, OC Boerman
Journal of Nuclear Medicine 2008
Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents
M Vaara, J Fox, G Loidl, O Siikanen, J Apajalahti, F Hansen, N Frimodt-Møller, J Nagai, M Takano, T Vaara
Antimicrobial agents and chemotherapy 2008
Apoptosis Induced by Aminoglycosides in LLC-PK1 Cells: Comparative Study of Neomycin, Gentamicin, Amikacin, and Isepamicin Using Electroporation
S Denamur, FV Bambeke, MP Mingeot-Leclercq, PM Tulkens
Antimicrobial agents and chemotherapy 2008
Identification and Design of Peptides as a New Drug Delivery System for the Brain
M Demeule, A Régina, C Ché, J Poirier, T Nguyen, R Gabathuler, JP Castaigne, R Béliveau
The Journal of pharmacology and experimental therapeutics 2007
Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation
H Servais, A Ortiz, O Devuyst, S Denamur, PM Tulkens, MP Mingeot-Leclercq
Apoptosis 2007
Direct tissue analysis by matrix-assisted laser desorption ionization mass spectrometry: application to kidney biology
KD Herring, SR Oppenheimer, RM Caprioli
Seminars in Nephrology 2007
Gene expression and immunohistochemical localization of megalin in the anterior pituitary gland of helmeted guinea fowl (Numida meleagris)
C Luziga, M Usui, H Yoichiro, R Kazwala, Y Yamamoto, K Mamba
Journal Of Molecular Histology 2007
Biodegradable gentamicin delivery systems for parenteral use for the treatment of intracellular bacterial infections
C Gamazo, S Prior, MC Lecároz, AI Vitas, MA Campanero, G Pérez, D Gonzalez, MJ Blanco-Prieto
Expert Opinion on Drug Delivery 2007
Vitamin B 12 and B 12 -Proteins: Kräutler/Vitamin
E Nexø
Vitamin B 12 and B 12 -Proteins: Kräutler/Vitamin 2007
Subclinical kidney injury incites endotoxin hyperresponsiveness
S Bolisetty, A Agarwal
American journal of physiology. Renal physiology 2007
Influence on Mitochondria and Cytotoxicity of Different Antibiotics Administered in High Concentrations on Primary Human Osteoblasts and Cell Lines
N Duewelhenke, O Krut, P Eysel
Antimicrobial agents and chemotherapy 2007
Renal albumin absorption in physiology and pathology
H Birn, EI Christensen
Kidney International 2006
Characterization of proteinuria and tubular protein uptake in a new model of oral L-lysine administration in rats
K Thelle, EI Christensen, H Vorum, H ørskov, H Birn
Kidney International 2006
Molecular Mechanisms Underlying Renal Accumulation of Aminoglycoside Antibiotics and Mechanism-based Approach for Developing Nonnephrotoxic Aminoglycoside Therapy
J NAGAI
YAKUGAKU ZASSHI 2006
Assessment of hemostasis through the retrospectroscope
RB Weiskopf
Journal of Thrombosis and Haemostasis 2006
Molecular and genetic aspects of aminoglycoside-induced hearing loss
AE Talaska, J Schacht, N Fischel-Ghodsian
Drug Discovery Today: Disease Mechanisms 2006
Inhibition of gentamicin binding to rat renal brush-border membrane by megalin ligands and basic peptides
J Nagai, M Saito, Y Adachi, R Yumoto, M Takano
Journal of Controlled Release 2006
Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis: Deafness in LIMP2 knockout mice
M Knipper, C Claussen, L Rüttiger, U Zimmermann, R Lüllmann-Rauch, EL Eskelinen, J Schröder, M Schwake, P Saftig
The Journal of Physiology 2006
The kidney in vitamin B 12 and folate homeostasis: characterization of receptors for tubular uptake of vitamins and carrier proteins
H Birn
American journal of physiology. Renal physiology 2006
Biomarker Discovery by Imaging Mass Spectrometry: Transthyretin is a Biomarker for Gentamicin-induced Nephrotoxicity in Rat
H Meistermann, JL Norris, HR Aerni, DS Cornett, A Friedlein, AR Erskine, A Augustin, MC de Mudry, S Ruepp, L Suter, H Langen, RM Caprioli, A Ducret
Molecular & cellular proteomics : MCP 2006
Loss of the Homotypic Fusion and Vacuole Protein Sorting or Golgi-Associated Retrograde Protein Vesicle Tethering Complexes Results in Gentamicin Sensitivity in the Yeast Saccharomyces cerevisiae
MC Wagner, EE Molnar, BA Molitoris, MG Goebl
Antimicrobial agents and chemotherapy 2006
Gentamicin Causes Apoptosis at Low Concentrations in Renal LLC-PK 1 Cells Subjected to Electroporation
H Servais, Y Jossin, FV Bambeke, PM Tulkens, MP Mingeot-Leclercq
Antimicrobial agents and chemotherapy 2006
Apolipoprotein E3 (apoE3) safeguards pig proximal tubular LLC-PK1 cells against reduction in SGLT1 activity induced by gentamicin C
K Takamoto, M Kawada, D Ikeda, M Yoshida
Biochimica et Biophysica Acta (BBA) - General Subjects 2005
Endocytosis of the somatostatin analogue, octreotide, by the proximal tubule-derived opossum kidney (OK) cell line
R Barone, PV der Smissen, O Devuyst, V Beaujean, S Pauwels, PJ Courtoy, F Jamar
Kidney International 2005
Comparison of para-aminophenol cytotoxicity in rat renal epithelial cells and hepatocytes
Y Li, CM Bentzley, JB Tarloff
Toxicology 2005
Light chains are a ligand for megalin
RB Klassen, PL Allen, V Batuman, K Crenshaw, TG Hammond
Journal of applied physiology 2005
Tales from the deep: reeling in renal failure
N Bahary
American journal of physiology. Renal physiology 2005
Molecular Aspects of Renal Handling of Aminoglycosides and Strategies for Preventing the Nephrotoxicity
J NAGAI, M TAKANO
Drug Metabolism and Pharmacokinetics 2004
Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists
A Watanabe, J Nagai, Y Adachi, T Katsube, Y Kitahara, T Murakami, M Takano
Journal of Controlled Release 2004
Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake
NS Chung, KM Wasan
Advanced Drug Delivery Reviews 2004
Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1
MC Nassogne, C Lizarraga, F N'Kuli, FV Bambeke, RV Binst, P Wallemacq, PM Tulkens, MP Mingeot-Leclercq, T Levade, PJ Courtoy
Toxicology and Applied Pharmacology 2004
Reviews of Physiology, Biochemistry and Pharmacology
B Gebert, W Fisher, R Haas
Reviews of Physiology, Biochemistry and Pharmacology 2004
Megalin mediates renal uptake of heavy metal metallothionein complexes
RB Klassen, K Crenshaw, R Kozyraki, PJ Verroust, L Tio, S Atrian, PL Allen, TG Hammond
American journal of physiology. Renal physiology 2004
Gentamicin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum
RM Sandoval, BA Molitoris
American journal of physiology. Renal physiology 2004
Protein reabsorption in renal proximal tubule?function and dysfunction in kidney pathophysiology
EI Christensen, J Gburek
Pediatric Nephrology 2004
Emerging drugs for renal failure
PK Chatterjee, C Thiemermann
Expert Opinion on Emerging Drugs 2003
RNA as a Drug Target: The Case of Aminoglycosides
Q Vicens, E Westhof
ChemBioChem 2003
Depletion of gentamicin and its major components from various tissues of turkeys
M Shem-Tov, N Gabor, M Suth, P Kormoczy
American Journal of Veterinary Research 2003
Intracellular pharmacodynamics of antibiotics
S Carryn, H Chanteux, C Seral, MP Mingeot-Leclercq, FV Bambeke, PM Tulkens
Infectious Disease Clinics of North America 2003
Uptake of Gentamicin by Bullfrog Saccular Hair Cells in vitro
PS Steyger, SL Peters, J Rehling, A Hordichok, CF Dai
Journal of the Association for Research in Otolaryngology 2003
Monoclonal Gammopathies and the Kidney
G Touchard, P Aucouturier, O Hermine, P Ronco
2003
Wiley Encyclopedia of Molecular Medicine
WT Morgan
Wiley Encyclopedia of Molecular Medicine 2002
The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology
PJ Verroust, H Birn, R Nielsen, R Kozyraki, EI Christensen
Kidney International 2002
Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism
J Hilpert, L Wogensen, T Thykjaer, M Wellner, U Schlichting, TF Orntoft, S Bachmann, A Nykjaer, TE Willnow
Kidney International 2002
Aminoglycoside antibiotics induce pH-sensitive activation of the calcium-sensing receptor
SJ McLarnon, D Holden, DT Ward, MN Jones, AC Elliott, D Riccardi
Biochemical and Biophysical Research Communications 2002
Cisplatin-induced inhibition of receptor-mediated endocytosis of protein in the kidney
M Takano, N Nakanishi, Y Kitahara, Y Sasaki, T Murakami, J Nagai
Kidney International 2002
Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity
D Ding, A Stracher, RJ Salvi
Hearing Research 2002
Megalin and cubilin: multifunctional endocytic receptors
EI Christensen, H Birn
Nature Reviews Molecular Cell Biology 2002
Effect of gentamicin on pharmacokinetics of lysozyme in rats: interaction between megalin substrates in the kidney
J Nagai, T Katsube, T Murakami, M Takano
Journal of Pharmacy and Pharmacology 2002
Chloride channels in the kidney: lessons learned from knockout animals
O Devuyst, WB Guggino
American journal of physiology. Renal physiology 2002
Clusterin protects renal tubular epithelial cells from gentamicin-mediated cytotoxicity
RA Girton, DP Sundin, ME Rosenberg
American journal of physiology. Renal physiology 2002
Nucleotide depletion increases trafficking of gentamicin to the Golgi complex in LLC-PK 1 cells
RM Sandoval, RL Bacallao, KW Dunn, JD Leiser, BA Molitoris
American journal of physiology. Renal physiology 2002
Hypocalcemia and osteopathy in mice with kidney‐specific megalin gene defect
JR Leheste, F Melsen, M Wellner, P Jansen, U Schlichting, I RennerMüller, TT Andreassen, E Wolf, S Bachmann, A Nykjaer, TE Willnow
The FASEB Journal 2002
Proteomic Analysis of Rat Kidney Cortex Following Treatment with Gentamicin
J Charlwood, JM Skehel, N King, P Camilleri, Peter, P Bugelski, U Atif
Journal of Proteome Research 2002
Aminoglycosides Increase Intracellular Calcium Levels and ERK Activity in Proximal Tubular OK Cells Expressing the Extracellular Calcium-Sensing Receptor
DT Ward, SJ McLarnon, D Riccardi
Journal of the American Society of Nephrology : JASN 2002
From interaction of lipidic vehicles with intestinal epithelial cell membranes to the formation and secretion of chylomicrons
H Shen, P Howles, P Tso
Advanced Drug Delivery Reviews 2001
Gentamicin causes endocytosis of Na/Pi cotransporter protein (NaPi-2)
V Sorribas, N Halaihel, K Puttaparthi, T Rogers, RE Cronin, AI Alcalde, J Aramayona, M Sarasa, H Wang, P Wilson, H Zajicek, M Levi
Kidney International 2001
The roles of cubilin and megalin, two multiligand receptors, in proximal tubule function: possible implication in the progression of renal disease
PJ Verroust, R Kozyraki
Current Opinion in Nephrology and Hypertension 2001
MEGALIN-ANDCUBILIN-MEDIATEDENDOCYTOSIS OFPROTEIN-BOUNDVITAMINS, LIPIDS,ANDHORMONES INPOLARIZEDEPITHELIA
SK Moestrup, PJ Verroust
Annual Review of Nutrition 2001
Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule
EI Christensen, H Birn
American journal of physiology. Renal physiology 2001
Role of megalin in renal handling of aminoglycosides
J Nagai, H Tanaka, N Nakanishi, T Murakami, M Takano
American journal of physiology. Renal physiology 2001
Aminoglycoside nephrotoxicity: do time and frequency of administration matter?:
D Beauchamp, G Labrecque
Current Opinion in Critical Care 2001
Transcellular Transport of Vitamin B 12 in LLC-PK1 Renal Proximal Tubule Cells
R Nielsen, BS Sørensen, H Birn, EI Christensen, E Nexø
Journal of the American Society of Nephrology : JASN 2001
Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney
XY Zhai, R Nielsen, H Birn, K Drumm, S Mildenberger, R Freudinger, SK Moestrup, PJ Verroust, EI Christensen, M Gekle
Kidney International 2000
Interference of antibacterial agents with phagocyte functions: immunomodulation or "immuno-fairy tales"?
MT Labro
Clinical microbiology reviews 2000
Lysosomal augmentation during aminoglycoside uptake in cochlear hair cells
E Hashino, M Shero, RJ Salvi
Brain Research 2000
PATHOPHYSIOLOGY AND MANAGEMENT OF RENAL INSUFFICIENCY IN THE PERIOPERATIVE AND CRITICALLY ILL PATIENT
M Hladunewich, MH Rosenthal
Anesthesiology Clinics of North America 2000
Gentamicin traffics rapidly and directly to the Golgi complex in LLC-PK 1 cells
RM Sandoval, KW Dunn, BA Molitoris
American journal of physiology. Renal physiology 2000
Nephrology and Geriatrics Integrated
DG Oreopoulos, WR Hazzard, R Luke
2000
Receptor-Associated Protein Is Important for Normal Processing of Megalin in Kidney Proximal Tubules
H Birn, H Vorum, PJ Verroust, SK Moestrup, EI Christensen
Journal of the American Society of Nephrology : JASN 2000
Interference of Antibacterial Agents with Phagocyte Functions: Immunomodulation or “Immuno-Fairy Tales”?
MT Labro
Clinical microbiology reviews 2000
Pharmacokinetics of Gentamicin C 1 , C 1a , and C 2 in Beagles after a Single Intravenous Dose
N Isoherranen, E Lavy, S Soback
Antimicrobial agents and chemotherapy 2000
An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3
A Nykjaer, D Dragun, D Walther, H Vorum, C Jacobsen, J Herz, F Melsen, EI Christensen, TE Willnow
Cell 1999
THE MAMMALIAN LOW-DENSITY LIPOPROTEIN RECEPTOR FAMILY
MM Hussain, DK Strickland, A Bakillah
Annual Review of Nutrition 1999
Glycoprotein 330/Megalin (LRP-2) Has Low Prevalence as mRNA and Protein in Brain Microvessels and Choroid Plexus
JT Chun, L Wang, GM Pasinetti, CE Finch, BV Zlokovic
Experimental Neurology 1999
Aminoglycosides: nephrotoxicity
MP Mingeot-Leclercq, PM Tulkens
Antimicrobial agents and chemotherapy 1999
Megalin knockout mice as an animal model of low molecular weight proteinuria
JR Leheste, B Rolinski, H Vorum, J Hilpert, A Nykjaer, C Jacobsen, P Aucouturier, JO Moskaug, A Otto, EI Christensen, TE Willnow
The American Journal of Pathology 1999
Endocytosis of gentamicin in a proximal tubular renal cell line
G Decorti, N Malusà, G Furlan, L Candussio, FB Klugmann
Life Sciences 1999
Ultrastructural localization of megalin in the rat cochlear duct
K Mizuta, A Saito, T Watanabe, M Nagura, M Arakawa, F Shimizu, T Hoshino
Hearing Research 1999
Megalin antagonizes activation of the parathyroid hormone receptor
J Hilpert, A Nykjaer, C Jacobsen, G Wallukat, R Nielsen, SK Moestrup, H Haller, FC Luft, EI Christensen, TE Willnow
The Journal of biological chemistry 1999
Renal Drug Delivery With Low-Molecular-Weight Proteins: The Effect of Charge Modifications on the Body Distribution of Drug-Lysozyme Conjugates
RJ Kok, F Grijpstra, KH Nederhoed, F Moolenaar, DD Zeeuw, DK Meijer
Drug Delivery 1999
Megalin (gp330) Is an Endocytic Receptor for Thyroglobulin on Cultured Fisher Rat Thyroid Cells
M Marinò, G Zheng, RT McCluskey
The Journal of biological chemistry 1999
Identification of a Heparin-binding Region of Rat Thyroglobulin Involved in Megalin Binding
M Marinò, JA Friedlander, RT McCluskey, D Andrews
The Journal of biological chemistry 1999
Specific Association of Megalin and the Na + /H + Exchanger Isoform NHE3 in the Proximal Tubule
D Biemesderfer, T Nagy, B DeGray, PS Aronson
The Journal of biological chemistry 1999
Identification of Megalin/gp330 as a Receptor for Lipoprotein(a) In Vitro
A Niemeier, T Willnow, H Dieplinger, C Jacobsen, N Meyer, J Hilpert, U Beisiegel
Arteriosclerosis, thrombosis, and vascular biology 1999
Evidence for an Essential Role of Megalin in Transepithelial Transport of Retinol
EI Christensen, JØ Moskaug, H Vorum, C Jacobsen, TE Gundersen, A Nykjær, R Blomhoff, TE Willnow, SK Moestrup
Journal of the American Society of Nephrology : JASN 1999
Essential Role of Megalin in Renal Proximal Tubule for Vitamin Homeostasis
EI Christensen, TE Willnow
Journal of the American Society of Nephrology : JASN 1999
Identification of Megalin as the Sole Rat Kidney Sialoglycoprotein Containing Poly α2,8 Deaminoneuraminic Acid
M Ziak, D Kerjaschki, MG Farquhar, J Roth
Journal of the American Society of Nephrology : JASN 1999
Antibiotics in Neonatal Infections: A Review
V Fanos, A DallAgnola
Drugs 1999
Antibacterial-Induced Nephrotoxicity in the Newborn:
V Fanos, L Cataldi
Drug Safety 1999
beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin
SK Moestrup, I Schousboe, C Jacobsen, JR Leheste, EI Christensen, TE Willnow
Journal of Clinical Investigation 1998
Cellular Distribution of Exogenous Aprotinin in the Rat Kidney
CP Vio, E Oestreicher, V Olavarria, V Velarde, RK Mayfield, AA Jaffa
Biological Chemistry 1998
Mild gentamicin nephrotoxicity reduces the progression of chronic adriamycin nephrosis
GK RANGAN, Y WANG, YC TAY, L CHEN, DC HARRIS
Nephrology 1998
Immortalized rat proximal tubule cells produce membrane bound and soluble megalin
FF Jung, DR Bachinsky, SS Tang, G Zheng, D Diamant, L Haveran, RT McCluskey, JR Ingelfinger
Kidney International 1998
Megalin-Mediated endocytosis in renal proximal tubule
EI Christensen, H Birn, P Verroust, SK Moestrup
Renal Failure 1998
Interaction of C1q and the Collections with the Potential Receptors Calreticulin (cClqR/Collectin Receptor) and Megalin
RB Sim, SK Moestrup, GR Stuart, NJ Lynch, J Lu, WJ Schwaeble, R Malhotra
Immunobiology 1998
Interaction of C1q and the Collectins with the Potential Receptors Calreticulin (cClqR/Collectin Receptor) and Megalin
RB Sim, SK Moestrup, GR Stuart, NJ Lynch, J Lu, WJ Schwaeble, R Malhotra
Immunobiology 1998
Principles of Medical Biology
JO Jørgensen
Principles of Medical Biology 1998
Ligand-receptor interactions of the low density lipoprotein receptor-related protein, a multi-ligand endocytic receptor
JG Neels, IR Horn, BM Berg, H Pannekoek, AJ Zonneveld
Fibrinolysis and Proteolysis 1998
Myeloma light chains are ligands for cubilin (gp280)
V Batuman, PJ Verroust, GL Navar, JH Kaysen, FO Goda, WC Campbell, E Simon, F Pontillon, M Lyles, J Bruno, TG Hammond
American journal of physiology. Renal physiology 1998
Inhibition of in Vitro Endosomal Vesicle Fusion Activity by Aminoglycoside Antibiotics
AT Jones, M Wessling-Resnick
The Journal of biological chemistry 1998
Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor
B Seetharam, EI Christensen, SK Moestrup, TG Hammond, PJ Verroust
Journal of Clinical Investigation 1997
Identification of the second cluster of ligand-binding repeats in megalin as a site for receptor-ligand interactions
RA Orlando, M Exner, RP Czekay, H Yamazaki, A Saito, R Ullrich, D Kerjaschki, MG Farquhar
Proceedings of the National Academy of Sciences 1997
Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes
RP Czekay, RA Orlando, L Woodward, M Lundstrom, MG Farquhar
Molecular biology of the cell 1997
Drug Nephrotoxicity: An Overview
WM Bennett
Renal Failure 1997
Characterization of an Epithelial ∼460-kDa Protein That Facilitates Endocytosis of Intrinsic Factor-Vitamin B 12 and Binds Receptor-associated Protein
H Birn, PJ Verroust, E Nexø, H Hager, C Jacobsen, EI Christensen, SK Moestrup
The Journal of biological chemistry 1997
Cellular mechanism of aminoglycoside tolerance in long-term gentamicin treatment
DP Sundin, C Meyer, R Dahl, A Geerdes, R Sandoval, BA Molitoris
American journal of physiology. Cell physiology 1997
Review
M Epstein
Renal Failure 1996
Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis
SK Moestrup, H Birn, PB Fischer, CM Petersen, PJ Verroust, RB Sim, EI Christensen, E Nexø
Proceedings of the National Academy of Sciences 1996
RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors
TE Willnow, A Rohlmann, J Horton, H Otani, JR Braun, RE Hammer, J Herz
The EMBO Journal 1996
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers
BV Zlokovic, CL Martel, E Matsubara, JG McComb, G Zheng, RT McCluskey, B Frangione, J Ghiso
Proceedings of the National Academy of Sciences 1996
The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II
CM Petersen, L Ellgaard, A Nykjaer, F Vilhardt, H Vorum, HC Thøgersen, MS Nielsen, C Jacobsen, SK Moestrup, J Gliemann
The EMBO Journal 1996
Cerebrovascular transport of Alzheimer's amyloidβ and apolipoproteins J and E: Possible anti-amyloidogenic role of the blood-brain barrier
BV Zlokovic
Life Sciences 1996
Identification of Residues in α-Macroglobulins Important for Binding to the α 2 -Macroglobulin Receptor/Low Density Lipoprotein Receptor-related Protein
KL Nielsen, TL Holtet, M Etzerodt, SK Moestrup, J Gliemann, L Sottrup-Jensen, HC Thøgersen
The Journal of biological chemistry 1996
The unfolding story of megalin (gp330): now recognized as a drug receptor
MG Farquhar
Journal of Clinical Investigation 1995
International Review of Cytology
RA Miller
International Review of Cytology 1991

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