S K Moestrup, S Cui, H Vorum, C Bregengård, S E Bjørn, K Norris, J Gliemann, E I Christensen
Title and authors | Publication | Year |
---|---|---|
Recent Advances in the Development of Polymyxin Antibiotics: 2010–2023
Slingerland CJ, Martin NI |
ACS Infectious Diseases | 2024 |
Fluid Shear Stress-Induced Changes in Megalin Trafficking Enhance Endocytic Capacity in Proximal Tubule Cells
Lackner EM, Cowan IA, Long KR, Weisz OA, Shipman KE |
2024 | |
Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model.
Durinova A, Smutna L, Barta P, Kamaraj R, Smutny T, Schmierer B, Pavek P, Trejtnar F |
2024 | |
Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract.
Mao T, Kim J, Peña-Hernández MA, Valle G, Moriyama M, Luyten S, Ott IM, Gomez-Calvo ML, Gehlhausen JR, Baker E, Israelow B, Slade M, Sharma L, Liu W, Ryu C, Korde A, Lee CJ, Silva Monteiro V, Lucas C, Dong H, Yang Y, Gopinath S, Wilen CB, Palm N, Dela Cruz CS, Iwasaki A |
Proceedings of the National Academy of Sciences | 2024 |
Fluid shear stress-induced changes in megalin trafficking enhance endocytic capacity in proximal tubule cells
Lackner EM, Cowan IA, Long KR, Weisz OA, Shipman KE |
Frontiers in physiology | 2024 |
Aprotinin (II): Inhalational Administration for the Treatment of COVID-19 and Other Viral Conditions
Padín JF, Pérez-Ortiz JM, Redondo-Calvo FJ |
International journal of molecular sciences | 2024 |
Megalin: A Sidekick or Nemesis of the Kidney?
Kulkarni K, Hussain T |
Journal of the American Society of Nephrology : JASN | 2024 |
Recoding of Nonsense Mutation as a Pharmacological Strategy
Temaj G, Telkoparan-Akillilar P, Nuhii N, Chichiarelli S, Saha S, Saso L |
Biomedicines | 2023 |
Peptide-Based Agents for Cancer Treatment: Current Applications and Future Directions.
Nhàn NTT, Yamada T, Yamada KH |
International journal of molecular sciences | 2023 |
Dietary supplementation of cystinotic mice by lysine inhibits the megalin pathway and decreases kidney cystine content.
Rega LR, Janssens V, Graversen JH, Moestrup SK, Cairoli S, Goffredo BM, Nevo N, Courtoy GE, Jouret F, Antignac C, Emma F, Pierreux CE, Courtoy PJ |
Scientific Reports | 2023 |
Flucloxacillin worsens while imipenem-cilastatin protects against vancomycin-induced kidney injury in a translational rat model.
Pais GM, Marianski S, Valdez K, Melicor RP, Liu J, Rohani R, Chang J, Tong SYC, Davis JS, Scheetz MH |
British Journal of Pharmacology | 2023 |
Mapping Adverse Outcome Pathways for Kidney Injury as a Basis for the Development of Mechanism-Based Animal-Sparing Approaches to Assessment of Nephrotoxicity.
Mally A, Jarzina S |
2022 | |
Megalin and Vitamin D Metabolism-Implications in Non-Renal Tissues and Kidney Disease.
Khan SS, Petkovich M, Holden RM, Adams MA |
Nutrients | 2022 |
A Clathrin light chain A reporter mouse for in vivo imaging of endocytosis.
Grimm E, van der Hoeven F, Sardella D, Willig KI, Engel U, Veits N, Engel R, Cavalcanti-Adam EA, Bestvater F, Bordoni L, Jennemann R, Schönig K, Schiessl IM, Sandhoff R |
PloS one | 2022 |
Synthesis and Evaluation of Polymyxins Bearing Reductively Labile Disulfide-Linked Lipids.
Slingerland CJ, Wesseling CMJ, Innocenti P, Westphal KGC, Masereeuw R, Martin NI |
Journal of Medicinal Chemistry | 2022 |
The Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis
J Chen, Y Su, S Pi, B Hu, L Mao |
Frontiers in Cardiovascular Medicine | 2021 |
Cylindrospermopsin impairs tubular transport function in kidney cells LLC-PK1
AC Moraes, DS Freire, H Habibi, J Lowe, VF Magalhães |
Toxicology Letters | 2021 |
Nonsense suppression therapies in human genetic diseases
P Martins-Dias, L Romão |
Cellular and Molecular Life Sciences | 2021 |
Functional megalin is expressed in renal cysts in a mouse model of adult polycystic kidney disease
ML Nielsen, MC Mundt, DL Lildballe, M Rasmussen, L Sunde, VE Torres, PC Harris, H Birn |
Clinical Kidney Journal | 2021 |
Immunoglobulin G Is a Novel Substrate for the Endocytic Protein Megalin
MA Bryniarski, B Zhao, LD Chaves, JH Mikkelsen, BM Yee, R Yacoub, S Shen, M Madsen, ME Morris |
The AAPS Journal | 2021 |
Polymyxin-induced nephrotoxicity and its predictors: a systematic review and meta-analysis of studies conducted using RIFLE criteria of acute kidney injury
M Sisay, B Hagos, D Edessa, Y Tadiwos, AN Mekuria |
Pharmacological research : the official journal of the Italian Pharmacological Society | 2021 |
Exploration of zebrafish larvae as an alternative whole-animal model for nephrotoxicity testing
B Bauer, D Liedtke, S Jarzina, E Stammler, K Kreisel, V Lalomia, M Diefenbacher, E Klopocki, A Mally |
Toxicology Letters | 2021 |
Nephroprotective Effect of Cilastatin against Gentamicin-Induced Renal Injury In Vitro and In Vivo without Altering Its Bactericidal Efficiency
JC Jado, B Humanes, MÁ González-Nicolás, S Camaño, JM Lara, B López, E Cercenado, J García-Bordas, A Tejedor, A Lázaro |
Antioxidants | 2020 |
The Role of Mitochondria in Drug-Induced Kidney Injury
Z Gai, T Gui, GA Kullak-Ublick, Y Li, M Visentin |
Frontiers in physiology | 2020 |
Translational readthrough inducing drugs for the treatment of inherited retinal dystrophies
CM Way, DL Cunha, M Moosajee |
Expert Review of Ophthalmology | 2020 |
Protective effect of cilastatin against diclofenac‐induced nephrotoxicity through interaction with diclofenac acyl glucuronide via organic anion transporters
X Huo, Q Meng, C Wang, J Wu, C Wang, Y Zhu, X Ma, H Sun, K Liu |
British Journal of Pharmacology | 2020 |
Low Density Receptor-Related Protein 1 Interactions With the Extracellular Matrix: More Than Meets the Eye
EE Bres, A Faissner |
Frontiers in Cell and Developmental Biology | 2019 |
Polymyxins and Their Potential Next Generation as Therapeutic Antibiotics
M Vaara |
Frontiers in microbiology | 2019 |
Molecular Mechanisms of Colistin-Induced Nephrotoxicity
Z Gai, S Samodelov, G Kullak-Ublick, M Visentin |
Molecules (Basel, Switzerland) | 2019 |
Renal globotriaosylceramide facilitates tubular albumin absorption and its inhibition protects against acute kidney injury
I Morace, R Pilz, G Federico, R Jennemann, D Krunic, V Nordström, J von Gerichten, C Marsching, IM Schießl, J Müthing, C Wunder, L Johannes, R Sandhoff, HJ Gröne |
Kidney International | 2019 |
A Review of the Clinical Pharmacokinetics of Polymyxin B
SN Avedissian, J Liu, NJ Rhodes, A Lee, GM Pais, AR Hauser, MH Scheetz |
Antibiotics | 2019 |
Mechanisms of antimicrobial-induced nephrotoxicity in children
KJ Downes, M Hayes, JC Fitzgerald, GM Pais, J Liu, NR Zane, SL Goldstein, MH Scheetz, AF Zuppa |
Journal of Antimicrobial Chemotherapy | 2019 |
Correlation of prechemotherapy urinary megalin ectodomain (A-megalin) levels with the development of cisplatin-induced nephrotoxicity: a prospective observational study
S Shoji, M Hosojima, H Kabasawa, R Kondo, S Miura, S Watanabe, N Aoki, R Kaseda, S Kuwahara, N Tanabe, Y Hirayama, I Narita, T Kikuchi, H Kagamu, A Saito |
BMC Cancer | 2019 |
Human Kidney on a Chip Assessment of Polymyxin Antibiotic Nephrotoxicity
Elijah Weber, Kevin A Lidberg, lu wang, Theo K Bammler, James MacDonald, Mavis Jiarong Li, Michelle Redhair, William M. Atkins, Cecilia K Tran, Kelly M. Hines, Josi Herron, Libin Xu, Maria B. Monteiro, Susanne Ramm, Vishal Vaidya, Martti Vaara, Timo Vaara, Jonathan Himmelfarb, Edward J. Kelly |
JCI Insight | 2018 |
Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codons
M Dabrowski, Z Bukowy-Bieryllo, E Zietkiewicz |
Molecular Medicine | 2018 |
Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner
S Gopinath, MV Kim, T Rakib, PW Wong, M van Zandt, NA Barry, T Kaisho, AL Goodman, A Iwasaki |
Nature Microbiology | 2018 |
The aminoglycoside antibiotic gentamicin is able to alter metabolic activity and morphology of MDCK-C11 cells: a cell model of intercalated cells
AG Coutinho, SM Biscaia, R Fernandez, AL Tararthuch |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2018 |
Aminoglycoside exposure and renal function before lung transplantation in adult cystic fibrosis patients
E Novel-Catin, S Pelletier, Q Reynaud, R Nove-Josserand, S Durupt, L Dubourg, I Durieu, D Fouque |
Nephrology Dialysis Transplantation | 2018 |
Cytochrome C suppresses renal accumulation and nephrotoxicity of polymyxin B
ZD Li, J Luo, LH Jia, XY Wang, ZK Xun, M Liu |
Human & Experimental Toxicology | 2018 |
An Endocytic Receptor, Megalin-Ligand Interactions: Effects of Glycosylation
M Hirano |
Trends in Glycoscience and Glycotechnology | 2018 |
Immature megalin expression in the preterm neonatal kidney is associated with urinary loss of vitamin carrier proteins
JR Charlton, MW Harer, C Swan, R Nielsen |
Pediatric Research | 2018 |
Towards the Prevention of Aminoglycoside-Related Hearing Loss
ME OSullivan, A Perez, R Lin, A Sajjadi, AJ Ricci, AG Cheng |
Frontiers in cellular neuroscience | 2017 |
Nonmuscle myosin 2 proteins encoded by Myh9 , Myh10 , and Myh14 are uniquely distributed in the tubular segments of murine kidney
KL Otterpohl, RG Hart, C Evans, K Surendran, I Chandrasekar |
Physiological Reports | 2017 |
Endocytic receptor LRP2/megalin—of holoprosencephaly and renal Fanconi syndrome
TE Willnow, A Christ |
Pflügers Archiv - European Journal of Physiology | 2017 |
Targeting renal fibrosis: Mechanisms and drug delivery systems
MV Nastase, J Zeng-Brouwers, M Wygrecka, L Schaefer |
Advanced Drug Delivery Reviews | 2017 |
Mechanism and evidence of nonsense suppression therapy for genetic eye disorders
R Richardson, M Smart, D Tracey-White, AR Webster, M Moosajee |
Experimental Eye Research | 2017 |
Role of Renal Drug Exposure in Polymyxin B-Induced Nephrotoxicity
P Manchandani, J Zhou, JT Babic, KR Ledesma, LD Truong, VH Tam |
Antimicrobial agents and chemotherapy | 2017 |
Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity
Y Hori, N Aoki, S Kuwahara, M Hosojima, R Kaseda, S Goto, T Iida, S De, H Kabasawa, R Kaneko, H Aoki, Y Tanabe, H Kagamu, I Narita, T Kikuchi, A Saito |
Journal of the American Society of Nephrology : JASN | 2017 |
Nonmuscle myosin 2 proteins encoded by Myh9 , Myh10 , and Myh14 are uniquely distributed in the tubular segments of murine kidney
KL Otterpohl, RG Hart, C Evans, K Surendran, I Chandrasekar |
Physiological Reports | 2017 |
Destination of aminoglycoside antibiotics in the ‘post-antibiotic era’
Y Takahashi, M Igarashi |
The Journal of Antibiotics | 2017 |
Gelofusine Ameliorates Colistin-Induced Nephrotoxicity
SS Sivanesan, MA Azad, EK Schneider, MU Ahmed, J Huang, J Wang, J Li, RL Nation, T Velkov |
Antimicrobial agents and chemotherapy | 2017 |
High dose of antibiotic colistin induces oligomerization of molecular chaperone HSP90
S Togashi, K Takahashi, A Tamura, I Toyota, S Hatakeyama, A Komatsuda, I Kudo, ES Kudoh, T Okamoto, A Haga, A Miyamoto, E Grave, T Sugawara, H Shimizu, H Itoh |
Journal of Biochemistry | 2017 |
Fagonia olivieri prevented hepatorenal injuries induced with gentamicin in rat
U Rashid, MR Khan |
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie | 2017 |
Recent advances and perspectives in the design and development of polymyxins
F Rabanal, Y Cajal |
Natural Product Reports | 2017 |
A special article following the relicence of aprotinin injection in Europe
D Royston, SD Hert, J der Linden, A Ouattara, K Zacharowski |
Anaesthesia Critical Care & Pain Medicine | 2017 |
Efficient megalin targeted delivery to renal proximal tubular cells mediated by modified-polymyxin B-polyethylenimine based nano-gene-carriers
F Oroojalian, AH Rezayan, F Mehrnejad, AH Nia, WT Shier, K Abnous, M Ramezani |
Materials science & engineering. C, Materials for biological applications | 2017 |
Urinary kidney injury biomarkers and tobramycin clearance among children and young adults with cystic fibrosis: a population pharmacokinetic analysis
KJ Downes, M Dong, T Fukuda, JP Clancy, C Haffner, MR Bennett, AA Vinks, SL Goldstein |
Journal of Antimicrobial Chemotherapy | 2016 |
Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance
D Scotcher, C Jones, A Rostami-Hodjegan, A Galetin |
European Journal of Pharmaceutical Sciences | 2016 |
Polymyxins facilitate entry into mammalian cells
KM Hamill, LS McCoy, E Wexselblatt, JD Esko, Y Tor |
Chemical Science | 2016 |
Lysosomes: Biology, Diseases, and Therapeutics: Biology, Diseases, and Therapeutics
S Lu, B Jessen, Y Will, G Stevens |
Lysosomes: Biology, Diseases, and Therapeutics: Biology, Diseases, and Therapeutics | 2016 |
Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity
Z Gai, M Visentin, C Hiller, E Krajnc, T Li, J Zhen, GA Kullak-Ublick |
Antimicrobial agents and chemotherapy | 2016 |
Nephrotoxicity of Polymyxins: Is There Any Difference between Colistimethate and Polymyxin B?
AP Zavascki, RL Nation |
Antimicrobial agents and chemotherapy | 2016 |
Role of Passive Diffusion, Transporters, and Membrane Trafficking-Mediated Processes in Cellular Drug Transport
E Cocucci, JY Kim, Y Bai, N Pabla |
Clinical Pharmacology & Therapeutics | 2016 |
The involvement of selected membrane transport mechanisms in the cellular uptake of 177Lu-labeled bombesin, somatostatin and gastrin analogues
M Volková, J Mandíková, A Lázníčková, M Lázníček, P Bárta, F Trejtnar |
Nuclear Medicine and Biology | 2015 |
A Renal-Targeted Triptolide Aminoglycoside (TPAG) Conjugate for Lowering Systemic Toxicities of Triptolide
B Qi, X Wang, Y Zhou, Q Han, L He, T Gong, X Sun, Y Fu, Z Zhang |
Fitoterapia | 2015 |
The Role of Megalin in the Transport of Gentamicin Across BeWo Cells, an In Vitro Model of the Human Placenta
AA Akour, MJ Kennedy, PM Gerk |
The AAPS Journal | 2015 |
Preliminary Clinical Study of the Effect of Ascorbic Acid on Colistin-Associated Nephrotoxicity
R Sirijatuphat, S Limmahakhun, V Sirivatanauksorn, RL Nation, J Li, V Thamlikitkul |
Antimicrobial agents and chemotherapy | 2015 |
Polymyxin B versus colistin: an update
Y Cai, W Lee, AL Kwa |
Expert Review of Anti-infective Therapy | 2015 |
Pediatric Nephrology
ED Avner, WE Harmon, P Niaudet, N Yoshikawa, F Emma, S Goldstein |
Pediatric Nephrology | 2015 |
Free Radicals in ENT Pathology
J Miller, CG Prell, L Rybak |
2015 | |
The Endocytic Receptor Megalin and its Associated Proteins in Proximal Tubule Epithelial Cells
S De, S Kuwahara, A Saito |
Membranes | 2014 |
Megalin-Mediated Specific Uptake of Chitosan/siRNA Nanoparticles in Mouse Kidney Proximal Tubule Epithelial Cells Enables AQP1 Gene Silencing
S Gao, S Hein, F Dagnæs-Hansen, K Weyer, C Yang, R Nielsen, EI Christensen, RA Fenton, J Kjems |
Theranostics | 2014 |
Therapeutic suppression of premature termination codons: mechanisms and clinical considerations (review)
J Karijolich, YT Yu |
International journal of molecular medicine | 2014 |
Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1
L Aschauer, G Carta, N Vogelsang, E Schlatter, P Jennings |
Toxicology in Vitro | 2014 |
In Vivo Enzyme Inhibition Improves the Targeting of [ 177 Lu]DOTA-GRP(13–27) in GRPR-Positive Tumors in Mice
PJ Marsouvanidis, M Melis, E Blois, WA Breeman, EP Krenning, T Maina, BA Nock, M Jong |
Cancer Biotherapy & Radiopharmaceuticals | 2014 |
Uptake of Polymyxin B into Renal Cells
K Abdelraouf, KT Chang, T Yin, M Hu, VH Tam |
Antimicrobial agents and chemotherapy | 2014 |
Entry of aminoglycosides into renal tubular epithelial cells via endocytosis-dependent and -independent pathways
J Nagai, M Takano |
Biochemical Pharmacology | 2014 |
Reference Module in Biomedical Sciences
DL Sackett, RB Haynes |
2014 | |
Megalin in acute kidney injury: foe and friend
R Mahadevappa, R Nielsen, EI Christensen, H Birn |
American journal of physiology. Renal physiology | 2014 |
Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics
G Xiao, LS Gan |
International Journal of Cell Biology | 2013 |
Receptor-Mediated Endocytosis across Human Placenta: Emphasis on Megalin
AA Akour, MJ Kennedy, P Gerk |
Molecular Pharmaceutics | 2013 |
Targeted drug delivery to renal proximal tubule epithelial cells mediated by 2-glucosamine
Y Lin, Y Li, X Wang, T Gong, L Zhang, X Sun |
Journal of Controlled Release | 2013 |
Influence of aminoglycoside antibiotics on chicken cystatin binding to renal brush-border membranes: Aminoglycosides and cystatin binding
B Konopska, J Gburek, K Gołąb, M Warwas |
Journal of Pharmacy and Pharmacology | 2013 |
Cisplatin-induced Ototoxicity in Pediatric Solid Tumors: The Role of Glutathione S-Transferases and Megalin Genetic Polymorphisms
W Choeyprasert, R Sawangpanich, K Lertsukprasert, U Udomsubpayakul, D Songdej, U Unurathapan, S Pakakasama, S Hongeng |
Journal of Pediatric Hematology/Oncology | 2013 |
Microspheres and Microcapsules in Biotechnology: Design, Preparation and Applications
C Jiang, X Jiang, Y Liu, K Shao, R Huang |
Microspheres and Microcapsules in Biotechnology: Design, Preparation and Applications | 2013 |
Drug Discovery: Practices, Processes, and Perspectives
A Chan, J Cross, Y He, B Lippa, D Ryan |
Drug Discovery: Practices, Processes, and Perspectives | 2013 |
Megalin contributes to kidney accumulation and nephrotoxicity of colistin
T Suzuki, H Yamaguchi, J Ogura, M Kobayashi, T Yamada, K Iseki |
Antimicrobial agents and chemotherapy | 2013 |
Early Prediction of Polymyxin-Induced Nephrotoxicity With Next-Generation Urinary Kidney Injury Biomarkers
ND Keirstead, MP Wagoner, P Bentley, M Blais, C Brown, L Cheatham, P Ciaccio, Y Dragan, D Ferguson, J Fikes, M Galvin, A Gupta, M Hale, N Johnson, W Luo, F McGrath, M Pietras, S Price, AG Sathe, JC Sasaki, D Snow, RL Walsky, G Kern |
Toxicological Sciences | 2013 |
Mechanics and Function of the Pulmonary Vasculature: Implications for Pulmonary Vascular Disease and Right Ventricular Function
S Lammers, D Scott, K Hunter, W Tan, R Shandas, KR Stenmark |
Comprehensive Physiology | 2012 |
Mechanics and Function of the Pulmonary Vasculature: Implications for Pulmonary Vascular Disease and Right Ventricular Function
S Lammers, D Scott, K Hunter, W Tan, R Shandas, KR Stenmark |
Comprehensive Physiology | 2012 |
Mechanics and Function of the Pulmonary Vasculature: Implications for Pulmonary Vascular Disease and Right Ventricular Function
S Lammers, D Scott, K Hunter, W Tan, R Shandas, KR Stenmark |
Comprehensive Physiology | 2012 |
Update of Research on Aminoglycoside Ototoxicity
JY Byun |
Korean Journal of Otorhinolaryngology - Head and Neck Surgery | 2012 |
Uriniferous Tubule: Structural and Functional Organization
EI Christensen, CA Wagner, B Kaissling |
Comprehensive Physiology | 2012 |
Chloride Transport
JC Edwards |
Comprehensive Physiology | 2012 |
Brenner and Rector's The Kidney
C Brugnara, KU Eckardt |
Brenner and Rector's The Kidney | 2012 |
Advances in Carbohydrate Chemistry and Biochemistry
D Mirelman, EA Bayer, Y Reisner |
Advances in Carbohydrate Chemistry and Biochemistry | 2012 |
Cisplatin and Aminoglycoside Antibiotics: Hearing Loss and Its Prevention
J Schacht, AE Talaska, LP Rybak |
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology | 2012 |
Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells
MP Mingeot-Leclercq, PM Tulkens, S Denamur, T Vaara, M Vaara |
Peptides | 2012 |
Colistin in burn intensive care: Back to the future?
EA Azzopardi, DE Boyce, DW Thomas, WA Dickson |
Burns | 2012 |
Gadolinium modulates gentamicin uptake via an endocytosis-independent pathway in HK-2 human renal proximal tubular cell line
T Sawada, J Nagai, Y Okada, R Yumoto, M Takano |
European Journal of Pharmacology | 2012 |
Effect of protamine on the accumulation of gentamicin in opossum kidney epithelial cells: Effect of protamine on GM uptake
J Nagai, T Komeda, R Yumoto, M Takano |
Journal of Pharmacy and Pharmacology | 2012 |
Characterization of polymyxin B-induced nephrotoxicity: implications for dosing regimen design
K Abdelraouf, KH Braggs, T Yin, LD Truong, M Hu, VH Tam |
Antimicrobial agents and chemotherapy | 2012 |
Endocytic Receptors in the Renal Proximal Tubule
EI Christensen, H Birn, T Storm, K Weyer, R Nielsen |
Physiology (Bethesda, Md.) | 2012 |
Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases
KM Keeling, DM Bedwell |
Wiley Interdisciplinary Reviews: RNA | 2011 |
Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54
SM Rowe, P Sloane, LP Tang, K Backer, M Mazur, J Buckley-Lanier, I Nudelman, V Belakhov, Z Bebok, E Schwiebert, T Baasov, DM Bedwell |
Journal of Molecular Medicine | 2011 |
Role of oxidative stress in lysosomal membrane permeabilization and apoptosis induced by gentamicin, an aminoglycoside antibiotic
S Denamur, D Tyteca, J Marchand-Brynaert, FV Bambeke, PM Tulkens, PJ Courtoy, MP Mingeot-Leclercq |
Free radical biology & medicine | 2011 |
New developments in aminoglycoside therapy and ototoxicity
J Xie, AE Talaska, J Schacht |
Hearing Research | 2011 |
Decreased renal accumulation of aminoglycoside reflects defective receptor-mediated endocytosis in cystic fibrosis and Dent’s disease
C Raggi, K Fujiwara, T Leal, F Jouret, O Devuyst, S Terryn |
Pflügers Archiv - European Journal of Physiology | 2011 |
Effects of gentamicin and gentamicin–RGD coatings on bone ingrowth and biocompatibility of cementless joint prostheses: An experimental study in rabbits
V Alt, A Bitschnau, F Böhner, KE Heerich, E Magesin, A Sewing, T Pavlidis, G Szalay, C Heiss, U Thormann, S Hartmann, W Pabst, S Wenisch, R Schnettler |
Acta Biomaterialia | 2011 |
Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma
T Miyamoto, R Asaka, A Suzuki, A Takatsu, H Kashima, T Shiozawa |
Experimental and Molecular Pathology | 2011 |
Enhanced accumulation of low-molecular-weight chitosan in kidneys: a study on the influence of N-acetylation of chitosan on the renal targeting
Z Yuan, J Li, D Zhu, X Sun, T Gong, Z Zhang |
Journal of Drug Targeting | 2011 |
Calreticulin Binds to Gentamicin and Reduces Drug-Induced Ototoxicity
T Karasawa, Q Wang, LL David, PS Steyger |
Toxicological Sciences | 2011 |
Prevention of hepatorenal toxicity with Sonchus asper in gentamicin treated rats
MR Khan, I Badar, A Siddiquah |
BMC complementary and alternative medicine | 2011 |
Mechanism underlying insulin uptake in alveolar epithelial cell line RLE-6TN
K Oda, R Yumoto, J Nagai, H Katayama, M Takano |
European Journal of Pharmacology | 2011 |
Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection
ME Huth, AJ Ricci, AG Cheng |
International Journal of Otolaryngology | 2011 |
Intracellular mechanisms of aminoglycoside-induced cytotoxicity
T Karasawa, PS Steyger |
Integrative biology : quantitative biosciences from nano to macro | 2011 |
Biomarkers in Kidney Disease
AS Cerdeira, SA Karumanchi |
Biomarkers in Kidney Disease | 2011 |
Antibiotic Discovery and Development
TJ Dougherty, MJ Pucci |
2011 | |
Burger's Medicinal Chemistry and Drug Discovery
S Bruno, L Ronda, S Faggiano, S Bettati, A Mozzarelli |
Burger's Medicinal Chemistry and Drug Discovery | 2010 |
Attenuation of gentamicin-induced nephrotoxicity: trimetazidine versus N-acetyl cysteine
LC de la Rodríguez, CR Araujo, SE Posleman, MR Rey |
Journal of Applied Toxicology | 2010 |
Analysis of the expression pattern of the carrier protein transthyretin and its receptor megalin in the human scalp skin and hair follicles: hair cycle-associated changes
MA Adly |
Histochemistry and Cell Biology | 2010 |
New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view
JM Lopez-Novoa, Y Quiros, L Vicente, AI Morales, FJ Lopez-Hernandez |
Kidney International | 2010 |
An Integrative Overview on the Mechanisms Underlying the Renal Tubular Cytotoxicity of Gentamicin
Y Quiros, L Vicente-Vicente, AI Morales, JM Lopez-Novoa, FJ Lopez-Hernandez |
Toxicological Sciences | 2010 |
Polymyxins and their novel derivatives
M Vaara |
Current Opinion in Microbiology | 2010 |
Molecular-targeted approaches to reduce renal accumulation of nephrotoxic drugs
J Nagai, M Takano |
Expert Opinion on Drug Metabolism & Toxicology | 2010 |
Identification of genes involved in gentamicin-induced nephrotoxicity in rats – A toxicogenomic investigation
N Ozaki, KA Matheis, M Gamber, T Feidl, T Nolte, A Kalkuhl, U Deschl |
Experimental and Toxicologic Pathology | 2010 |
Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells
DJ Antoine, A Srivastava, M Pirmohamed, BK Park |
Biochemical Pharmacology | 2010 |
Comprehensive Toxicology
JM Sands, JW Verlander |
Comprehensive Toxicology | 2010 |
Renoprotective effects of paricalcitol on gentamicin-induced kidney injury in rats
JW Park, EH Bae, IJ Kim, SK Ma, C Choi, JU Lee, SW Kim |
American journal of physiology. Renal physiology | 2010 |
Functional Ultrastructure
M Pavelka, J Roth |
2010 | |
Designing functional foods
CM Lo, P Tso |
Designing functional foods | 2009 |
Poly-L-aspartic acid enhances and prolongs gentamicin-mediated suppression of the CFTR-G542X mutation in a cystic fibrosis mouse model
M Du, KM Keeling, L Fan, X Liu, DM Bedwell |
The Journal of biological chemistry | 2009 |
Lipopeptides as anti-infectives: a practical perspective
G Pirri, A Giuliani, SF Nicoletto, L Pizzuto, AC Rinaldi |
Central European Journal of Biology | 2009 |
Receptor-mediated therapeutic transport across the blood–brain barrier
YY Wang, PC Lui, JY Li |
Immunotherapy | 2009 |
Disruption of gap junctional intercellular communication by antibiotic gentamicin is associated with aberrant localization of occludin, N-cadherin, connexin 43, and vimentin in SerW3 Sertoli cells in vitro
SH Bekheet, R Stahlmann |
Environmental Toxicology and Pharmacology | 2009 |
Poly-l-aspartic Acid Enhances and Prolongs Gentamicin-mediated Suppression of the CFTR -G542X Mutation in a Cystic Fibrosis Mouse Model
M Du, KM Keeling, L Fan, X Liu, DM Bedwell |
The Journal of biological chemistry | 2009 |
Drug Delivery to the Central Nervous System
KK Jain |
2009 | |
Effect of PEGylation of N-WASP181-200 on the Inhibitory Potency for Renal Aminoglycoside Accumulation
K Fujii, J Nagai, T Sawada, R Yumoto, M Takano |
Bioconjugate Chemistry | 2009 |
Cystic fibrosis, aminoglycoside treatment and acute renal failure: the not so gentle micin
D Bockenhauer, MJ Hug, R Kleta |
Pediatric Nephrology | 2009 |
Calcium-sensing receptor antagonism or lithium treatment ameliorates aminoglycoside-induced cell death in renal epithelial cells
CE Gibbons, D Maldonado-Pérez, AN Shah, D Riccardi, DT Ward |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2008 |
Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery
KM Wasan, DR Brocks, SD Lee, K Sachs-Barrable, SJ Thornton |
Nature Reviews Drug Discovery | 2008 |
Gene expression analysis defines the proximal tubule as the compartment for endocytic receptor-mediated uptake in the Xenopus pronephric kidney
EI Christensen, D Raciti, L Reggiani, PJ Verroust, AW Brändli |
Pflügers Archiv - European Journal of Physiology | 2008 |
Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2
M Demeule, JC Currie, Y Bertrand, C Ché, T Nguyen, A Régina, R Gabathuler, JP Castaigne, R Béliveau |
Journal of Neurochemistry | 2008 |
Increased Incidence of Acute Kidney Injury with Aprotinin Use during Cardiac Surgery Detected with Urinary NGAL
G Wagener, G Gubitosa, S Wang, N Borregaard, M Kim, HT Lee |
American Journal of Nephrology | 2008 |
Comprehensive Pediatric Nephrology
R Gbadegesin, WE Smoyer |
Comprehensive Pediatric Nephrology | 2008 |
A megalin-like receptor is involved in protein endocytosis in the midgut of an insect ( Bombyx mori , Lepidoptera)
M Casartelli, G Cermenati, S Rodighiero, F Pennacchio, B Giordana |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2008 |
hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics
M Wieser, G Stadler, P Jennings, B Streubel, W Pfaller, P Ambros, C Riedl, H Katinger, J Grillari, R Grillari-Voglauer |
American journal of physiology. Renal physiology | 2008 |
Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss
O König, L Rüttiger, M Müller, U Zimmermann, B Erdmann, H Kalbacher, M Gross, M Knipper |
The FASEB Journal | 2008 |
Specific Renal Uptake of Randomly 50% N -Acetylated Low Molecular Weight Chitosan
Z Yuan, Z Zhang, D Zhu, X Sun, T Gong, J Liu, C Luan |
Molecular Pharmaceutics | 2008 |
Clinical Nephrotoxins
ME Broe, GA Porter, WM Bennett, G Deray |
2008 | |
Auditory Trauma, Protection, and Repair
J Schacht, AN Popper, RR Fay |
2008 | |
Reducing Renal Uptake of Radiolabeled Peptides Using Albumin Fragments
E Vegt, JE van Eerd, A Eek, WJ Oyen, JF Wetzels, M de Jong, FG Russel, R Masereeuw, M Gotthardt, OC Boerman |
Journal of Nuclear Medicine | 2008 |
Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents
M Vaara, J Fox, G Loidl, O Siikanen, J Apajalahti, F Hansen, N Frimodt-Møller, J Nagai, M Takano, T Vaara |
Antimicrobial agents and chemotherapy | 2008 |
Apoptosis Induced by Aminoglycosides in LLC-PK1 Cells: Comparative Study of Neomycin, Gentamicin, Amikacin, and Isepamicin Using Electroporation
S Denamur, FV Bambeke, MP Mingeot-Leclercq, PM Tulkens |
Antimicrobial agents and chemotherapy | 2008 |
Identification and Design of Peptides as a New Drug Delivery System for the Brain
M Demeule, A Régina, C Ché, J Poirier, T Nguyen, R Gabathuler, JP Castaigne, R Béliveau |
The Journal of pharmacology and experimental therapeutics | 2007 |
Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation
H Servais, A Ortiz, O Devuyst, S Denamur, PM Tulkens, MP Mingeot-Leclercq |
Apoptosis | 2007 |
Direct tissue analysis by matrix-assisted laser desorption ionization mass spectrometry: application to kidney biology
KD Herring, SR Oppenheimer, RM Caprioli |
Seminars in Nephrology | 2007 |
Gene expression and immunohistochemical localization of megalin in the anterior pituitary gland of helmeted guinea fowl (Numida meleagris)
C Luziga, M Usui, H Yoichiro, R Kazwala, Y Yamamoto, K Mamba |
Journal Of Molecular Histology | 2007 |
Biodegradable gentamicin delivery systems for parenteral use for the treatment of intracellular bacterial infections
C Gamazo, S Prior, MC Lecároz, AI Vitas, MA Campanero, G Pérez, D Gonzalez, MJ Blanco-Prieto |
Expert Opinion on Drug Delivery | 2007 |
Vitamin B 12 and B 12 -Proteins: Kräutler/Vitamin
E Nexø |
Vitamin B 12 and B 12 -Proteins: Kräutler/Vitamin | 2007 |
Subclinical kidney injury incites endotoxin hyperresponsiveness
S Bolisetty, A Agarwal |
American journal of physiology. Renal physiology | 2007 |
Influence on Mitochondria and Cytotoxicity of Different Antibiotics Administered in High Concentrations on Primary Human Osteoblasts and Cell Lines
N Duewelhenke, O Krut, P Eysel |
Antimicrobial agents and chemotherapy | 2007 |
Renal albumin absorption in physiology and pathology
H Birn, EI Christensen |
Kidney International | 2006 |
Characterization of proteinuria and tubular protein uptake in a new model of oral L-lysine administration in rats
K Thelle, EI Christensen, H Vorum, H ørskov, H Birn |
Kidney International | 2006 |
Molecular Mechanisms Underlying Renal Accumulation of Aminoglycoside Antibiotics and Mechanism-based Approach for Developing Nonnephrotoxic Aminoglycoside Therapy
J NAGAI |
YAKUGAKU ZASSHI | 2006 |
Assessment of hemostasis through the retrospectroscope
RB Weiskopf |
Journal of Thrombosis and Haemostasis | 2006 |
Molecular and genetic aspects of aminoglycoside-induced hearing loss
AE Talaska, J Schacht, N Fischel-Ghodsian |
Drug Discovery Today: Disease Mechanisms | 2006 |
Inhibition of gentamicin binding to rat renal brush-border membrane by megalin ligands and basic peptides
J Nagai, M Saito, Y Adachi, R Yumoto, M Takano |
Journal of Controlled Release | 2006 |
Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis: Deafness in LIMP2 knockout mice
M Knipper, C Claussen, L Rüttiger, U Zimmermann, R Lüllmann-Rauch, EL Eskelinen, J Schröder, M Schwake, P Saftig |
The Journal of Physiology | 2006 |
The kidney in vitamin B 12 and folate homeostasis: characterization of receptors for tubular uptake of vitamins and carrier proteins
H Birn |
American journal of physiology. Renal physiology | 2006 |
Biomarker Discovery by Imaging Mass Spectrometry: Transthyretin is a Biomarker for Gentamicin-induced Nephrotoxicity in Rat
H Meistermann, JL Norris, HR Aerni, DS Cornett, A Friedlein, AR Erskine, A Augustin, MC de Mudry, S Ruepp, L Suter, H Langen, RM Caprioli, A Ducret |
Molecular & cellular proteomics : MCP | 2006 |
Loss of the Homotypic Fusion and Vacuole Protein Sorting or Golgi-Associated Retrograde Protein Vesicle Tethering Complexes Results in Gentamicin Sensitivity in the Yeast Saccharomyces cerevisiae
MC Wagner, EE Molnar, BA Molitoris, MG Goebl |
Antimicrobial agents and chemotherapy | 2006 |
Gentamicin Causes Apoptosis at Low Concentrations in Renal LLC-PK 1 Cells Subjected to Electroporation
H Servais, Y Jossin, FV Bambeke, PM Tulkens, MP Mingeot-Leclercq |
Antimicrobial agents and chemotherapy | 2006 |
Apolipoprotein E3 (apoE3) safeguards pig proximal tubular LLC-PK1 cells against reduction in SGLT1 activity induced by gentamicin C
K Takamoto, M Kawada, D Ikeda, M Yoshida |
Biochimica et Biophysica Acta (BBA) - General Subjects | 2005 |
Endocytosis of the somatostatin analogue, octreotide, by the proximal tubule-derived opossum kidney (OK) cell line
R Barone, PV der Smissen, O Devuyst, V Beaujean, S Pauwels, PJ Courtoy, F Jamar |
Kidney International | 2005 |
Comparison of para-aminophenol cytotoxicity in rat renal epithelial cells and hepatocytes
Y Li, CM Bentzley, JB Tarloff |
Toxicology | 2005 |
Light chains are a ligand for megalin
RB Klassen, PL Allen, V Batuman, K Crenshaw, TG Hammond |
Journal of applied physiology | 2005 |
Tales from the deep: reeling in renal failure
N Bahary |
American journal of physiology. Renal physiology | 2005 |
Molecular Aspects of Renal Handling of Aminoglycosides and Strategies for Preventing the Nephrotoxicity
J NAGAI, M TAKANO |
Drug Metabolism and Pharmacokinetics | 2004 |
Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists
A Watanabe, J Nagai, Y Adachi, T Katsube, Y Kitahara, T Murakami, M Takano |
Journal of Controlled Release | 2004 |
Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake
NS Chung, KM Wasan |
Advanced Drug Delivery Reviews | 2004 |
Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1
MC Nassogne, C Lizarraga, F N'Kuli, FV Bambeke, RV Binst, P Wallemacq, PM Tulkens, MP Mingeot-Leclercq, T Levade, PJ Courtoy |
Toxicology and Applied Pharmacology | 2004 |
Reviews of Physiology, Biochemistry and Pharmacology
B Gebert, W Fisher, R Haas |
Reviews of Physiology, Biochemistry and Pharmacology | 2004 |
Megalin mediates renal uptake of heavy metal metallothionein complexes
RB Klassen, K Crenshaw, R Kozyraki, PJ Verroust, L Tio, S Atrian, PL Allen, TG Hammond |
American journal of physiology. Renal physiology | 2004 |
Gentamicin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum
RM Sandoval, BA Molitoris |
American journal of physiology. Renal physiology | 2004 |
Protein reabsorption in renal proximal tubule?function and dysfunction in kidney pathophysiology
EI Christensen, J Gburek |
Pediatric Nephrology | 2004 |
Emerging drugs for renal failure
PK Chatterjee, C Thiemermann |
Expert Opinion on Emerging Drugs | 2003 |
RNA as a Drug Target: The Case of Aminoglycosides
Q Vicens, E Westhof |
ChemBioChem | 2003 |
Depletion of gentamicin and its major components from various tissues of turkeys
M Shem-Tov, N Gabor, M Suth, P Kormoczy |
American Journal of Veterinary Research | 2003 |
Intracellular pharmacodynamics of antibiotics
S Carryn, H Chanteux, C Seral, MP Mingeot-Leclercq, FV Bambeke, PM Tulkens |
Infectious Disease Clinics of North America | 2003 |
Uptake of Gentamicin by Bullfrog Saccular Hair Cells in vitro
PS Steyger, SL Peters, J Rehling, A Hordichok, CF Dai |
Journal of the Association for Research in Otolaryngology | 2003 |
Monoclonal Gammopathies and the Kidney
G Touchard, P Aucouturier, O Hermine, P Ronco |
2003 | |
Wiley Encyclopedia of Molecular Medicine
WT Morgan |
Wiley Encyclopedia of Molecular Medicine | 2002 |
The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology
PJ Verroust, H Birn, R Nielsen, R Kozyraki, EI Christensen |
Kidney International | 2002 |
Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism
J Hilpert, L Wogensen, T Thykjaer, M Wellner, U Schlichting, TF Orntoft, S Bachmann, A Nykjaer, TE Willnow |
Kidney International | 2002 |
Aminoglycoside antibiotics induce pH-sensitive activation of the calcium-sensing receptor
SJ McLarnon, D Holden, DT Ward, MN Jones, AC Elliott, D Riccardi |
Biochemical and Biophysical Research Communications | 2002 |
Cisplatin-induced inhibition of receptor-mediated endocytosis of protein in the kidney
M Takano, N Nakanishi, Y Kitahara, Y Sasaki, T Murakami, J Nagai |
Kidney International | 2002 |
Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity
D Ding, A Stracher, RJ Salvi |
Hearing Research | 2002 |
Megalin and cubilin: multifunctional endocytic receptors
EI Christensen, H Birn |
Nature Reviews Molecular Cell Biology | 2002 |
Effect of gentamicin on pharmacokinetics of lysozyme in rats: interaction between megalin substrates in the kidney
J Nagai, T Katsube, T Murakami, M Takano |
Journal of Pharmacy and Pharmacology | 2002 |
Chloride channels in the kidney: lessons learned from knockout animals
O Devuyst, WB Guggino |
American journal of physiology. Renal physiology | 2002 |
Clusterin protects renal tubular epithelial cells from gentamicin-mediated cytotoxicity
RA Girton, DP Sundin, ME Rosenberg |
American journal of physiology. Renal physiology | 2002 |
Nucleotide depletion increases trafficking of gentamicin to the Golgi complex in LLC-PK 1 cells
RM Sandoval, RL Bacallao, KW Dunn, JD Leiser, BA Molitoris |
American journal of physiology. Renal physiology | 2002 |
Hypocalcemia and osteopathy in mice with kidney‐specific megalin gene defect
JR Leheste, F Melsen, M Wellner, P Jansen, U Schlichting, I RennerMüller, TT Andreassen, E Wolf, S Bachmann, A Nykjaer, TE Willnow |
The FASEB Journal | 2002 |
Proteomic Analysis of Rat Kidney Cortex Following Treatment with Gentamicin
J Charlwood, JM Skehel, N King, P Camilleri, Peter, P Bugelski, U Atif |
Journal of Proteome Research | 2002 |
Aminoglycosides Increase Intracellular Calcium Levels and ERK Activity in Proximal Tubular OK Cells Expressing the Extracellular Calcium-Sensing Receptor
DT Ward, SJ McLarnon, D Riccardi |
Journal of the American Society of Nephrology : JASN | 2002 |
From interaction of lipidic vehicles with intestinal epithelial cell membranes to the formation and secretion of chylomicrons
H Shen, P Howles, P Tso |
Advanced Drug Delivery Reviews | 2001 |
Gentamicin causes endocytosis of Na/Pi cotransporter protein (NaPi-2)
V Sorribas, N Halaihel, K Puttaparthi, T Rogers, RE Cronin, AI Alcalde, J Aramayona, M Sarasa, H Wang, P Wilson, H Zajicek, M Levi |
Kidney International | 2001 |
The roles of cubilin and megalin, two multiligand receptors, in proximal tubule function: possible implication in the progression of renal disease
PJ Verroust, R Kozyraki |
Current Opinion in Nephrology and Hypertension | 2001 |
MEGALIN-ANDCUBILIN-MEDIATEDENDOCYTOSIS OFPROTEIN-BOUNDVITAMINS, LIPIDS,ANDHORMONES INPOLARIZEDEPITHELIA
SK Moestrup, PJ Verroust |
Annual Review of Nutrition | 2001 |
Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule
EI Christensen, H Birn |
American journal of physiology. Renal physiology | 2001 |
Role of megalin in renal handling of aminoglycosides
J Nagai, H Tanaka, N Nakanishi, T Murakami, M Takano |
American journal of physiology. Renal physiology | 2001 |
Aminoglycoside nephrotoxicity: do time and frequency of administration matter?:
D Beauchamp, G Labrecque |
Current Opinion in Critical Care | 2001 |
Transcellular Transport of Vitamin B 12 in LLC-PK1 Renal Proximal Tubule Cells
R Nielsen, BS Sørensen, H Birn, EI Christensen, E Nexø |
Journal of the American Society of Nephrology : JASN | 2001 |
Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney
XY Zhai, R Nielsen, H Birn, K Drumm, S Mildenberger, R Freudinger, SK Moestrup, PJ Verroust, EI Christensen, M Gekle |
Kidney International | 2000 |
Interference of antibacterial agents with phagocyte functions: immunomodulation or "immuno-fairy tales"?
MT Labro |
Clinical microbiology reviews | 2000 |
Lysosomal augmentation during aminoglycoside uptake in cochlear hair cells
E Hashino, M Shero, RJ Salvi |
Brain Research | 2000 |
PATHOPHYSIOLOGY AND MANAGEMENT OF RENAL INSUFFICIENCY IN THE PERIOPERATIVE AND CRITICALLY ILL PATIENT
M Hladunewich, MH Rosenthal |
Anesthesiology Clinics of North America | 2000 |
Gentamicin traffics rapidly and directly to the Golgi complex in LLC-PK 1 cells
RM Sandoval, KW Dunn, BA Molitoris |
American journal of physiology. Renal physiology | 2000 |
Nephrology and Geriatrics Integrated
DG Oreopoulos, WR Hazzard, R Luke |
2000 | |
Receptor-Associated Protein Is Important for Normal Processing of Megalin in Kidney Proximal Tubules
H Birn, H Vorum, PJ Verroust, SK Moestrup, EI Christensen |
Journal of the American Society of Nephrology : JASN | 2000 |
Interference of Antibacterial Agents with Phagocyte Functions: Immunomodulation or “Immuno-Fairy Tales”?
MT Labro |
Clinical microbiology reviews | 2000 |
Pharmacokinetics of Gentamicin C 1 , C 1a , and C 2 in Beagles after a Single Intravenous Dose
N Isoherranen, E Lavy, S Soback |
Antimicrobial agents and chemotherapy | 2000 |
An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3
A Nykjaer, D Dragun, D Walther, H Vorum, C Jacobsen, J Herz, F Melsen, EI Christensen, TE Willnow |
Cell | 1999 |
THE MAMMALIAN LOW-DENSITY LIPOPROTEIN RECEPTOR FAMILY
MM Hussain, DK Strickland, A Bakillah |
Annual Review of Nutrition | 1999 |
Glycoprotein 330/Megalin (LRP-2) Has Low Prevalence as mRNA and Protein in Brain Microvessels and Choroid Plexus
JT Chun, L Wang, GM Pasinetti, CE Finch, BV Zlokovic |
Experimental Neurology | 1999 |
Aminoglycosides: nephrotoxicity
MP Mingeot-Leclercq, PM Tulkens |
Antimicrobial agents and chemotherapy | 1999 |
Megalin knockout mice as an animal model of low molecular weight proteinuria
JR Leheste, B Rolinski, H Vorum, J Hilpert, A Nykjaer, C Jacobsen, P Aucouturier, JO Moskaug, A Otto, EI Christensen, TE Willnow |
The American Journal of Pathology | 1999 |
Endocytosis of gentamicin in a proximal tubular renal cell line
G Decorti, N Malusà, G Furlan, L Candussio, FB Klugmann |
Life Sciences | 1999 |
Ultrastructural localization of megalin in the rat cochlear duct
K Mizuta, A Saito, T Watanabe, M Nagura, M Arakawa, F Shimizu, T Hoshino |
Hearing Research | 1999 |
Megalin antagonizes activation of the parathyroid hormone receptor
J Hilpert, A Nykjaer, C Jacobsen, G Wallukat, R Nielsen, SK Moestrup, H Haller, FC Luft, EI Christensen, TE Willnow |
The Journal of biological chemistry | 1999 |
Renal Drug Delivery With Low-Molecular-Weight Proteins: The Effect of Charge Modifications on the Body Distribution of Drug-Lysozyme Conjugates
RJ Kok, F Grijpstra, KH Nederhoed, F Moolenaar, DD Zeeuw, DK Meijer |
Drug Delivery | 1999 |
Megalin (gp330) Is an Endocytic Receptor for Thyroglobulin on Cultured Fisher Rat Thyroid Cells
M Marinò, G Zheng, RT McCluskey |
The Journal of biological chemistry | 1999 |
Identification of a Heparin-binding Region of Rat Thyroglobulin Involved in Megalin Binding
M Marinò, JA Friedlander, RT McCluskey, D Andrews |
The Journal of biological chemistry | 1999 |
Specific Association of Megalin and the Na + /H + Exchanger Isoform NHE3 in the Proximal Tubule
D Biemesderfer, T Nagy, B DeGray, PS Aronson |
The Journal of biological chemistry | 1999 |
Identification of Megalin/gp330 as a Receptor for Lipoprotein(a) In Vitro
A Niemeier, T Willnow, H Dieplinger, C Jacobsen, N Meyer, J Hilpert, U Beisiegel |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
Evidence for an Essential Role of Megalin in Transepithelial Transport of Retinol
EI Christensen, JØ Moskaug, H Vorum, C Jacobsen, TE Gundersen, A Nykjær, R Blomhoff, TE Willnow, SK Moestrup |
Journal of the American Society of Nephrology : JASN | 1999 |
Essential Role of Megalin in Renal Proximal Tubule for Vitamin Homeostasis
EI Christensen, TE Willnow |
Journal of the American Society of Nephrology : JASN | 1999 |
Identification of Megalin as the Sole Rat Kidney Sialoglycoprotein Containing Poly α2,8 Deaminoneuraminic Acid
M Ziak, D Kerjaschki, MG Farquhar, J Roth |
Journal of the American Society of Nephrology : JASN | 1999 |
Antibiotics in Neonatal Infections: A Review
V Fanos, A DallAgnola |
Drugs | 1999 |
Antibacterial-Induced Nephrotoxicity in the Newborn:
V Fanos, L Cataldi |
Drug Safety | 1999 |
beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin
SK Moestrup, I Schousboe, C Jacobsen, JR Leheste, EI Christensen, TE Willnow |
Journal of Clinical Investigation | 1998 |
Cellular Distribution of Exogenous Aprotinin in the Rat Kidney
CP Vio, E Oestreicher, V Olavarria, V Velarde, RK Mayfield, AA Jaffa |
Biological Chemistry | 1998 |
Mild gentamicin nephrotoxicity reduces the progression of chronic adriamycin nephrosis
GK RANGAN, Y WANG, YC TAY, L CHEN, DC HARRIS |
Nephrology | 1998 |
Immortalized rat proximal tubule cells produce membrane bound and soluble megalin
FF Jung, DR Bachinsky, SS Tang, G Zheng, D Diamant, L Haveran, RT McCluskey, JR Ingelfinger |
Kidney International | 1998 |
Megalin-Mediated endocytosis in renal proximal tubule
EI Christensen, H Birn, P Verroust, SK Moestrup |
Renal Failure | 1998 |
Interaction of C1q and the Collections with the Potential Receptors Calreticulin (cClqR/Collectin Receptor) and Megalin
RB Sim, SK Moestrup, GR Stuart, NJ Lynch, J Lu, WJ Schwaeble, R Malhotra |
Immunobiology | 1998 |
Interaction of C1q and the Collectins with the Potential Receptors Calreticulin (cClqR/Collectin Receptor) and Megalin
RB Sim, SK Moestrup, GR Stuart, NJ Lynch, J Lu, WJ Schwaeble, R Malhotra |
Immunobiology | 1998 |
Principles of Medical Biology
JO Jørgensen |
Principles of Medical Biology | 1998 |
Ligand-receptor interactions of the low density lipoprotein receptor-related protein, a multi-ligand endocytic receptor
JG Neels, IR Horn, BM Berg, H Pannekoek, AJ Zonneveld |
Fibrinolysis and Proteolysis | 1998 |
Myeloma light chains are ligands for cubilin (gp280)
V Batuman, PJ Verroust, GL Navar, JH Kaysen, FO Goda, WC Campbell, E Simon, F Pontillon, M Lyles, J Bruno, TG Hammond |
American journal of physiology. Renal physiology | 1998 |
Inhibition of in Vitro Endosomal Vesicle Fusion Activity by Aminoglycoside Antibiotics
AT Jones, M Wessling-Resnick |
The Journal of biological chemistry | 1998 |
Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor
B Seetharam, EI Christensen, SK Moestrup, TG Hammond, PJ Verroust |
Journal of Clinical Investigation | 1997 |
Identification of the second cluster of ligand-binding repeats in megalin as a site for receptor-ligand interactions
RA Orlando, M Exner, RP Czekay, H Yamazaki, A Saito, R Ullrich, D Kerjaschki, MG Farquhar |
Proceedings of the National Academy of Sciences | 1997 |
Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes
RP Czekay, RA Orlando, L Woodward, M Lundstrom, MG Farquhar |
Molecular biology of the cell | 1997 |
Drug Nephrotoxicity: An Overview
WM Bennett |
Renal Failure | 1997 |
Characterization of an Epithelial ∼460-kDa Protein That Facilitates Endocytosis of Intrinsic Factor-Vitamin B 12 and Binds Receptor-associated Protein
H Birn, PJ Verroust, E Nexø, H Hager, C Jacobsen, EI Christensen, SK Moestrup |
The Journal of biological chemistry | 1997 |
Cellular mechanism of aminoglycoside tolerance in long-term gentamicin treatment
DP Sundin, C Meyer, R Dahl, A Geerdes, R Sandoval, BA Molitoris |
American journal of physiology. Cell physiology | 1997 |
Review
M Epstein |
Renal Failure | 1996 |
Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis
SK Moestrup, H Birn, PB Fischer, CM Petersen, PJ Verroust, RB Sim, EI Christensen, E Nexø |
Proceedings of the National Academy of Sciences | 1996 |
RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors
TE Willnow, A Rohlmann, J Horton, H Otani, JR Braun, RE Hammer, J Herz |
The EMBO Journal | 1996 |
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers
BV Zlokovic, CL Martel, E Matsubara, JG McComb, G Zheng, RT McCluskey, B Frangione, J Ghiso |
Proceedings of the National Academy of Sciences | 1996 |
The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II
CM Petersen, L Ellgaard, A Nykjaer, F Vilhardt, H Vorum, HC Thøgersen, MS Nielsen, C Jacobsen, SK Moestrup, J Gliemann |
The EMBO Journal | 1996 |
Cerebrovascular transport of Alzheimer's amyloidβ and apolipoproteins J and E: Possible anti-amyloidogenic role of the blood-brain barrier
BV Zlokovic |
Life Sciences | 1996 |
Identification of Residues in α-Macroglobulins Important for Binding to the α 2 -Macroglobulin Receptor/Low Density Lipoprotein Receptor-related Protein
KL Nielsen, TL Holtet, M Etzerodt, SK Moestrup, J Gliemann, L Sottrup-Jensen, HC Thøgersen |
The Journal of biological chemistry | 1996 |
The unfolding story of megalin (gp330): now recognized as a drug receptor
MG Farquhar |
Journal of Clinical Investigation | 1995 |
International Review of Cytology
RA Miller |
International Review of Cytology | 1991 |