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Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis.

K E Balashov, … , D A Hafler, H L Weiner

K E Balashov, … , D A Hafler, H L Weiner

Published June 1, 1995
Citation Information: J Clin Invest. 1995;95(6):2711-2719. https://doi.org/10.1172/JCI117973.

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Citations to this article (93)

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Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE LV Kaer, JL Postoak, C Wang, G Yang, L Wu	Cellular and Molecular Immunology	2019
Immunometabolism: A new target for improving cancer immunotherapy Guo C, Chen S, Liu W, Ma Y, Li J, Fisher PB, Fang X, Wang XY	Advances in cancer research	2019
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Impact of the microbiome on cancer progression and response to anti-cancer therapies Buchta Rosean C, Feng TY, Azar FN, Rutkowski MR	Advances in cancer research	2019
The expanding family of noncanonical regulatory cell subsets H Zhao, R Feng, A Peng, G Li, L Zhou	Journal of leukocyte biology	2019
Description of CD8 + Regulatory T Lymphocytes and Their Specific Intervention in Graft-versus-Host and Infectious Diseases, Autoimmunity, and Cancer MR Vieyra-Lobato, J Vela-Ojeda, L Montiel-Cervantes, R López-Santiago, MC Moreno-Lafont	Journal of Immunology Research	2018
IL-10 inducible CD8+ regulatory T-cells are enriched in patients with multiple myeloma and impact the generation of antigen-specific T-cells J Plaumann, M Engelhardt, MH Awwad, H Echchannaoui, E Amman, MS Raab, J Hillengass, N Halama, B Neuber, C Müller-Tidow, H Goldschmidt, M Hundemer	Cancer Immunology, Immunotherapy	2018
Molecular mechanisms underlying Th1-like Treg generation and function A Kitz, M Dominguez-Villar	Cellular and Molecular Life Sciences	2017
Memory CD4(+) T cells are suppressed by CD8(+) regulatory T cells in vitro and in vivo Xin Long, Qi Cheng, Huifang Liang, Jianping Zhao, Jian Wang, Wei Wang, Stephen Tomlinson, Lin Chen, Carl Atkinson, Bixiang Zhang, Xiaoping Chen, Peng Zhu	American journal of translational research	2017
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The influence and impact of ageing and immunosenescence (ISC) on adaptive immunity during multiple sclerosis (MS) and the animal counterpart experimental autoimmune encephalomyelitis (EAE) C Bolton, PA Smith	Ageing Research Reviews	2017
Stage-Specific Role of Interferon-Gamma in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis G Arellano, PA Ottum, LI Reyes, PI Burgos, R Naves	Frontiers in immunology	2015
CD8+ T-Cells as Immune Regulators of Multiple Sclerosis S Sinha, AW Boyden, FR Itani, MP Crawford, NJ Karandikar	Frontiers in immunology	2015
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Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells K Cunnusamy, EJ Baughman, J Franco, SB Ortega, S Sinha, P Chaudhary, BM Greenberg, EM Frohman, NJ Karandikar	Clinical Immunology	2014
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High and dysregulated secretion of epidermal growth factor from immune cells of patients with relapsing-remitting multiple sclerosis YA Levy, KM Fainberg, T Amidror, K Regev, E Auriel, A Karni	Journal of Neuroimmunology	2013
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Circulating CD4+ CD25brightFOXP3+ regulatory T-cells are significantly reduced in bullous pemphigoid patients P Quaglino, E Antiga, A Comessatti, M Caproni, T Nardò, R Ponti, M Novelli, S Osella-Abate, P Fabbri, MG Bernengo	Archives of Dermatological Research	2012
Cyclophosphamide inhibits the generation and function of CD8(+) regulatory T cells I Traverso, D Fenoglio, S Negrini, A Parodi, F Battaglia, F Kalli, G Conteduca, S Tardito, P Traverso, F Indiveri, G Filaci	Human Immunology	2012
Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes EB Remmerswaal, SH Havenith, MM Idu, EM van Leeuwen, KA van Donselaar, A Brinke, N der Bom-Baylon, FJ Bemelman, RA van Lier, IJ Berge	Blood	2011
CD8+ Tregs in autoimmunity: learning “self”-control from experience S Tsai, X Clemente-Casares, P Santamaria	Cellular and Molecular Life Sciences	2011
Reduced ErbB4 Expression in Immune Cells of Patients with Relapsing Remitting Multiple Sclerosis E Tynyakov-Samra, E Auriel, Y Levy-Amir, A Karni	Multiple Sclerosis International	2011
Reduced production of noggin by immune cells of patients with relapsing–remitting multiple sclerosis N Urshansky, K Mausner-Fainberg, E Auriel, K Regev, NM Bornstein, A Karni	Journal of Neuroimmunology	2011
Immune regulatory CNS-reactive CD8+T cells in experimental autoimmune encephalomyelitis NR York, JP Mendoza, SB Ortega, A Benagh, AF Tyler, M Firan, NJ Karandikar	Journal of Autoimmunity	2010
CD8(+) T regulatory/suppressor cells and their relationships with autoreactivity and autoimmunity G Filaci, D Fenoglio, F Indiveri	Autoimmunity	2010
Emerging concepts in autoimmune encephalomyelitis beyond the CD4/TH1 paradigm H Batoulis, K Addicks, S Kuerten	Annals of Anatomy - Anatomischer Anzeiger	2010
Novel CD8+Treg suppress EAE by TGF-Î²- and IFN-Î³-dependent mechanisms ML Chen, BS Yan, D Kozoriz, HL Weiner	European Journal of Immunology	2009
Efficient induction and expansion of human alloantigen-specific CD8 regulatory T cells from naive precursors by CD40-activated B cells J Zheng, Y Liu, G Qin, PL Chan, H Mao, KT Lam, DB Lewis, YL Lau, W Tu	Journal of immunology (Baltimore, Md. : 1950)	2009
Optimized peptide vaccines eliciting extensive CD8 T-cell responses with therapeutic antitumor effects HI Cho, E Celis	Cancer research	2009
Changes in T cell phenotype and activated MAPKs are correlated to impaired cellular responses to antigens and glucocorticoids during HTLV-I infection MM Pillat, BL Correa, CF da Rocha, GC Müller, RP Lopes, SS Lampert, AL Teixeira, M Menna-Barreto, ME Bauer	Journal of Neuroimmunology	2009
Regulatory T Cell (Treg) Subsets Return in Patients with Refractory Lupus following Stem Cell Transplantation, and TGF-β-Producing CD8 + Treg Cells Are Associated with Immunological Remission of Lupus L Zhang, AM Bertucci, R Ramsey-Goldman, RK Burt, SK Datta	Journal of immunology (Baltimore, Md. : 1950)	2009
TGF-beta and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells M Elrefaei, CM Burke, CA Baker, NG Jones, S Bousheri, DR Bangsberg, H Cao	PloS one	2009
Handbook on Immunosenescence T Fulop, C Franceschi, K Hirokawa, G Pawelec		2009
Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection D Azoulay, N Urshansky, A Karni	Journal of Neuroimmunology	2008
Induction of immune tolerance by activation of CD8+ T suppressor/regulatory cells in lupus-prone mice BJ Skaggs, RP Singh, BH Hahn	Human Immunology	2008
Revival of CD8+ Treg–mediated suppression TR Smith, V Kumar	Trends in Immunology	2008
The role of CD8 suppressors versus destructors in autoimmune central nervous system inflammation AL Zozulya, H Wiendl	Human Immunology	2008
Generation and function of human regulatory CD8+ T cells induced by a humanized OKT3 monoclonal antibody hOKT3γ1(Ala-Ala) V Ablamunits, KC Herold	Human Immunology	2008
Alloantigen-induced regulatory CD8+CD103+ T cells SD Koch, E Uss, RA van Lier, IJ Berge	Human Immunology	2008
Increased levels of activated T-cells and reduced levels of CD4/CD25+ cells in peripheral blood of Guillain-Barré syndrome patients compared to controls J Harness, PA McCombe	Journal of Clinical Neuroscience	2008
Advancements on phenotypic and functional characterization of non-antigen-specific CD8+CD28- regulatory T cells D Fenoglio, F Ferrera, M Fravega, P Balestra, F Battaglia, M Proietti, C Andrei, D Olive, LC Antonio, F Indiveri, G Filaci	Human Immunology	2008
CD8 + CD28 − , suppressive T cells in systemic lupus erythematosus A Tulunay, S Yavuz, H Direskeneli, E Eksioglu-Demiralp	Lupus	2008
CD40Ig treatment results in allograft acceptance mediated by CD8+CD45RClow T cells, IFNgamma and indoleamine 2,3 dioxygenase Carole Guillonneau, Marcelo Hill, François-Xavier Hubert, Elise Chiffoleau, Caroline Hervé, Xian-Liang Li, Michèle Heslan, Claire Usal, Laurent Tesson, Séverine Ménoret, Abdelhadi Saoudi, Régis Josien, Maria Cristina Cuturi, Ignacio Anegon	Journal of Clinical Investigation	2007
CD8+ CD28- T regulatory lymphocytes inhibiting T cell proliferative and cytotoxic functions infiltrate human cancers G Filaci, D Fenoglio, M Fravega, G Ansaldo, G Borgonovo, P Traverso, B Villaggio, A Ferrera, A Kunkl, M Rizzi, F Ferrera, P Balestra, M Ghio, P Contini, M Setti, D Olive, B Azzarone, G Carmignani, JL Ravetti, G Torre, F Indiveri	Journal of immunology (Baltimore, Md. : 1950)	2007
HIV-Specific IL-10-Positive CD8 + T Cells Suppress Cytolysis and IL-2 Production by CD8 + T Cells M Elrefaei, FL Ventura, CA Baker, R Clark, DR Bangsberg, H Cao	Journal of immunology (Baltimore, Md. : 1950)	2007
CSF enrichment of highly differentiated CD8+ T cells in early multiple sclerosis S Jilek, M Schluep, AO Rossetti, L Guignard, GL Goff, G Pantaleo, RA du Pasquier	Clinical Immunology	2007
Long-Term Staphylococcal Enterotoxin C1 Exposure Induces Soluble Factor-Mediated Immunosuppression by Bovine CD4 + and CD8 + T Cells KS Seo, SU Lee, YH Park, WC Davis, LK Fox, GA Bohach	Infection and immunity	2007
Regulatory T cells in patients with systemic lupus erythematosus B Alvarado-Sánchez, B Hernández-Castro, D Portales-Pérez, L Baranda, E Layseca-Espinosa, C Abud-Mendoza, AC Cubillas-Tejeda, R González-Amaro	Journal of Autoimmunity	2006
Apoptosis of T cells in peripheral blood and cerebrospinal fluid is associated with disease activity of multiple sclerosis Y Okuda, BR Apatoff, DN Posnett	Journal of Neuroimmunology	2006
CD8+ T cell activation correlates with disease activity in clinically isolated syndromes and is regulated by interferon-β treatment J Jensen, AR Langkilde, JL Frederiksen, F Sellebjerg	Journal of Neuroimmunology	2006
Multiple Sclerosis — The Plaque and Its Pathogenesis EM Frohman, MK Racke, CS Raine	New England Journal of Medicine	2006
Glatiramer acetate-specific human CD8+ T cells: Increased IL-4 production in multiple sclerosis is reduced by glatiramer acetate treatment A Dressel, A Vogelgesang, H Brinkmeier, M Mäder, F Weber	Journal of Neuroimmunology	2006
Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis DK Tennakoon, RS Mehta, SB Ortega, V Bhoj, MK Racke, NJ Karandikar	Journal of immunology (Baltimore, Md. : 1950)	2006
Functional and phenotypic characterization of CD8+CD28+ and CD28− T cells in atopic individuals sensitized to Dermatophagoides pteronyssinus O Lourenço, AM Fonseca, A Paiva, FA Arosa, L Taborda-Barata	Allergologia et Immunopathologia	2006
Endocrine Regulation of Suppressor Lymphocytes: Role of the Glucocorticoid-Induced TNF-Like Receptor S Negrini	Annals of the New York Academy of Sciences	2006
Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy? MA Friese, L Fugger	Brain	2005
Non-antigen-specific CD8(+) T suppressor lymphocytes in diseases characterized by chronic immune responses and inflammation G Filaci, M Rizzi, M Setti, D Fenoglio, M Fravega, M Basso, G Ansaldo, P Ceppa, G Borgonovo, G Murdaca, F Ferrera, A Picciotto, R Fiocca, G Torre, F Indiveri	Annals of the New York Academy of Sciences	2005
Regulatory T Cells in Autoimmune Diseases: Anti-Ergotypic T Cells A Mimran, IR Cohen	International Reviews of Immunology	2005
Massive Apoptosis in Lymphoid Organs in Animal Models for Primary and Secondary Progressive Multiple Sclerosis I Tsunoda, JE Libbey, LQ Kuang, EJ Terry, RS Fujinami	The American Journal of Pathology	2005
The activation of memory CD4+ T cells and CD8+ T cells in patients with multiple sclerosis Y Okuda, M Okuda, BR Apatoff, DN Posnett	Journal of the Neurological Sciences	2005
T cell targeted immunotherapy for autoimmune disease E Lee, AA Sinha	Autoimmunity	2005
High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay MP Crawford, SX Yan, SB Ortega, RS Mehta, RE Hewitt, DA Price, P Stastny, DC Douek, RA Koup, MK Racke, NJ Karandikar	Blood	2004
Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+CD28− T cells and inhibit both T-Cell proliferation and CTL function G Filaci, M Fravega, S Negrini, F Procopio, D Fenoglio, M Rizzi, S Brenci, P Contini, D Olive, M Ghio, M Setti, RS Accolla, F Puppo, F Indiveri	Human Immunology	2004
Role of cytokines in the pathogenesis of autoimmune diabetes mellitus. Rabinovitch A, Suarez-Pinzon WL	Reviews in endocrine & metabolic disorders	2003
Cytokines and Chemokines in Autoimmune Disease P Santamaria		2003
Glatiramer acetate (Copaxone) therapy Induces CD8+ T cell responses in patients with Multiple Sclerosis Nitin J. Karandikar, Michael P. Crawford, Robert B. Ratts, Jason M. Brenchley, David R. Ambrozak, Amy E. Lovett-Racke, Elliot M. Frohman, Peter Stastny, Daniel C. Douek, Richard A. Koup, Michael K. Racke	Journal of Clinical Investigation	2002
Chemokine receptors associated with immunity within and outside the central nervous system in early relapsing–remitting multiple sclerosis HY Wang, M Matsui, S Araya, N Onai, K Matsushima, T Saida	Journal of Neuroimmunology	2002
Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans MV Dhodapkar, RM Steinman	Blood	2002
Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells M Allez, J Brimnes, I Dotan, L Mayer	Gastroenterology	2002
Tc1/Tc2 and Th1/Th2 balance in Asian and Western types of multiple sclerosis, HTLV-I-associated myelopathy/tropical spastic paraparesis and hyperIgEaemic myelitis H Ochi, XM Wu, M Osoegawa, I Horiuchi, M Minohara, H Murai, Y Ohyagi, H Furuya, J Kira	Journal of Neuroimmunology	2001
Tacrolimus, but not Cyclosporine A, significantly increases expression of ICAM-1 and IFN-? in the NOD mouse G Papaccio, MV Latronico, A Graziano, A Lanza, M Pedull	Journal of Cellular Biochemistry	2001
Intracellular cytokine profile in T-cell subsets of multiple sclerosis patients: different features in primary progressive disease J Killestein, BF Drijver, WL van der Graaff, BM Uitdehaag, CH Polman, RA van Lier	Multiple sclerosis (Houndmills, Basingstoke, England)	2001
Interleukin-12 Receptor/STAT4 Signaling Is Required for the Development of Autoimmune Myocarditis in Mice by an Interferon-γ–Independent Pathway M Afanasyeva, Y Wang, Z Kaya, EA Stafford, KM Dohmen, AA Akha, NR Rose	Circulation	2001
Impairment of CD8 + T Suppressor Cell Function in Patients with Active Systemic Lupus Erythematosus G Filaci, S Bacilieri, M Fravega, M Monetti, P Contini, M Ghio, M Setti, F Puppo, F Indiveri	Journal of immunology (Baltimore, Md. : 1950)	2001
Increased numbers of mononuclear cells from blood and CSF expressing interferon-gamma mRNA in multiple sclerosis are from both the CD4+ and the CD8+ subsets E Wallstrom, M Khademi, M Andersson, T Olsson	European Journal of Neurology	2000
Interferon-? secretion by peripheral blood T-cell subsets in multiple sclerosis: Correlation with disease phase and interferon-? therapy B Becher, PS Giacomini, D Pelletier, E McCrea, A Prat, JP Antel	Annals of Neurology	1999
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Disproportionate Recruitment of CD8+ T Cells into the Central Nervous System by Professional Antigen-Presenting Cells MJ Carson, CR Reilly, JG Sutcliffe, D Lo	The American Journal of Pathology	1999
Autoimmunity Is a Type I Interferon-Deficiency Syndrome Corrected by Ingested Type I IFN via the GALT System SA Brod	Journal of Interferon & Cytokine Research	1999
Changes in serum levels of ICAM and TNF-R correlate with disease activity in multiple sclerosis SJ Khoury, EJ Orav, CR Guttmann, R Kikinis, FA Jolesz, HL Weiner	Neurology	1999
A dimeric form of soluble recombinant sheep LFA-3(CD58) inhibits human T-cell proliferation by generating regulatory T cells K Yamashita, T Kakutani, T Ohashi, T Saibara	Immunopharmacology	1997
Inhibition of the Progression of Multiple Sclerosis by Linomide Is Associated with Upregulation of CD4+/CD45RA+Cells and Downregulation of CD4+/CD45RO+Cells D Lehmann, D Karussis, R Mizrachi-Koll, AS Linde, O Abramsky	Clinical Immunology and Immunopathology	1997
CD27/CD70 Interaction Contributes to the Activation and the Function of Human Autoreactive CD27+Regulatory T Cells S Jacquot, T Kobata, S Iwata, SF Schlossman, C Morimoto	Cellular Immunology	1997
Human CD8+ TCR-αβ+ and TCR-γδ+ cells modulate autologous autoreactive neuroantigen-specific CD4+ T-cells by different mechanisms J Correale, M Rojany, LP Weiner	Journal of Neuroimmunology	1997
Increased in Vitro Induced CD4+ and Cd8+ T Cell Ifn-GM and CD4+ T Cell Il-10 Production in Stable Relapsing Multiple Sclerosis SA Brod, LD Nelson, M Khan, JS Wolinsky	International Journal of Neuroscience	1997
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