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Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis.
A A Quyyumi, … , J A Panza, R O Cannon 3rd
A A Quyyumi, … , J A Panza, R O Cannon 3rd
Published April 1, 1995
Citation Information: J Clin Invest. 1995;95(4):1747-1755. https://doi.org/10.1172/JCI117852.
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Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis.

Abstract

The bioavailability of nitric oxide (NO) in the human coronary circulation at rest and after acetylcholine (ACH)-induced vasodilation was investigated in 32 patients with angiographically normal coronary arteries. The effects of intracoronary L-NG monomethyl arginine (L-NMMA) were investigated at rest and after ACH, sodium nitroprusside, and adenosine. L-NMMA (64 mumol/min) increased resting coronary vascular resistance by 22% (P < 0.001), reduced distal epicardial coronary artery diameter by 12.6% (P < 0.001), and inhibited ACH-induced coronary epicardial and microvascular vasodilation. These effects were reversed with intracoronary L-arginine. L-NMMA did not inhibit dilation in response to sodium nitroprusside and adenosine. 23 patients were exposed to one or more coronary risk factors. The vasoconstrictor effect of L-NMMA on the epicardial and microvessels was greater in patients free of risk factors: Coronary vascular resistance was 36% higher in patients without risks, compared to 17% higher in patients with risks (P < 0.05). Both epicardial and microvascular dilator effects of ACH were greater in patients without risk factors, and the inhibition of these effects by L-NMMA was also greater in patients without risk factors. Thus: (a) NO contributes importantly to resting epicardial and coronary microvascular tone, (b) coronary vascular dilation in response to ACH is predominantly due to increased production of NO, and (c) despite the absence of angiographic evidence of atherosclerosis, exposure to coronary risk factors is associated with reduced resting and stimulated bioavailability of NO from the human coronary circulation.

Authors

A A Quyyumi, N Dakak, N P Andrews, S Husain, S Arora, D M Gilligan, J A Panza, R O Cannon 3rd

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A Sureda, P Tauler, A Aguiló, E Fuentespina, A Córdova, JA Tur, A Pons 		Nitric Oxide 2006
Pre-eclampsia is associated with sleep-disordered breathing and endothelial dysfunction
D Yinon, L Lowenstein, S Suraya, R Beloosesky, O Zmora, A Malhotra, G Pillar 		The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006
Effects of Enalapril, Tempol, and Eplerenone on Salt-Induced Hypertension in Dahl Salt-Sensitive Rats
MA Bayorh, G Mann, M Walton, D Eatman 		Clinical and Experimental Hypertension 2006
Aged Garlic Extract Improves Homocysteine-Induced Endothelial Dysfunction in Macro- and Microcirculation
N Weiss, N Ide, T Abahji, L Nill, C Keller, U Hoffmann 		The Journal of nutrition 2006
Endothelial cell dysfunction: The syndrome in making
E O'Riordan, J Chen, SV Brodsky, I Smirnova, H Li, MS Goligorsky 		Kidney International 2005
Kardiovaskuläre Manifestationen bei Rheumatoider Arthritis
F Moritz, U Wagner, O Distler, W Seidel, S Gay, H Häntzschel 		Zeitschrift für Rheumatologie 2005
Smoking-gene Interaction and Disease Development: Relevance to Pancreatic Cancer and Atherosclerosis
XL Wang, J Wang 		World Journal of Surgery 2005
Cyclic AMP-specific and cyclic GMP-specific phosphodiesterase isoenzymes in human cavernous arteries—immunohistochemical distribution and functional significance
E Waldkirch, S Ückert, H Yildirim, M Sohn, U Jonas, CG Stief, KE Andersson, P Hedlund 		World Journal of Urology 2005
Asymmetric dimethylarginine (ADMA) and the risk for coronary heart disease: the multicenter CARDIAC study
H Lenzen, D Tsikas, RH Böger 		European Journal of Clinical Pharmacology 2005
The effect of glucose and mental stress on cutaneous microvascular endothelial function
MJ Brion, PD Drummond 		Psychophysiology 2005
Plasma Nitric Oxide Level and Its Role in Slow Coronary Flow Phenomenon
N Sezgin, I Barutcu, AT Sezgin, H Gullu, M Turkmen, AM Esen, O Karakaya 		International Heart Journal 2005
Prospects for Personalized Cardiovascular Medicine
GS Ginsburg, MP Donahue, LK Newby 		Journal of the American College of Cardiology 2005
Clinical impact of vasomotor function assessment and the role of ACE-inhibitors and statins
FW Asselbergs, P der Harst, GA Jessurun, RA Tio, WH van Gilst 		Vascular Pharmacology 2005
Relación del óxido nítrico con el síndrome de isquemia/reperfusión en el pinzamiento aórtico
C López-Espada, JP Linares-Palomino, G Escames, D Acuña-Castroviejo, E Ros-Díe 		Angiología 2005
Expression of urotensin-II in human coronary atherosclerosis
GS Hassan, SA Douglas, EH Ohlstein, A Giaid 		Peptides 2005
Alterations in Aldosterone and Angiotensin II Levels in Salt-Induced Hypertension
MA Bayorh, AA Ganafa, N Emmett, RR Socci, D Eatman, IL Fridie 		Clinical and Experimental Hypertension 2005
Endothelial cell dysfunction: can’t live with it, how to live without it
MS Goligorsky 		American journal of physiology. Renal physiology 2005
Analysis of nitric oxide donor effectiveness in resistance vessels
DR Hyduke, JC Liao 		American journal of physiology. Heart and circulatory physiology 2005
Nitric oxide inhibition unmasks ischemic myocardium-derived vasoconstrictor signals activating endothelin type A receptor of coronary microvessels
K Takahashi, T Komaru, S Takeda, K Sato, H Kanatsuka, K Shirato 		American journal of physiology. Heart and circulatory physiology 2005
Elevated C-reactive protein levels and coronary microvascular dysfunction in patients with coronary artery disease
F Tomai, F Ribichini, AS Ghini, V Ferrero, G Andò, C Vassanelli, F Romeo, F Crea, L Chiariello 		European Heart Journal 2005
Rho-Kinase Mediates Hyperglycemia-Induced Plasminogen Activator Inhibitor-1 Expression in Vascular Endothelial Cells
Y Rikitake, JK Liao 		Circulation 2005
Calcium Channel Blockades Exhibit Anti-Inflammatory and Antioxidative Effects by Augmentation of Endothelial Nitric Oxide Synthase and the Inhibition of Angiotensin Converting Enzyme in the NG-Nitro-L-Arginine Methyl Ester-Induced Hypertensive Rat Aorta: Vasoprotective Effects beyond the Blood Pressure-Lowering Effects of Amlodipine and Manidipine
H TOBA, Y NAKAGAWA, S MIKI, T SHIMIZU, A YOSHIMURA, R INOUE, J ASAYAMA, M KOBARA, T NAKATA 		Hypertension Research 2005
Weight changes and obesity predict impaired resting and endothelium-dependent myocardial blood flow in postmenopausal women: Obesity and myocardial blood flow in postmenopausal women
JW Martin, K Briesmiester, A Bargardi, O Muzik, L Mosca, CS Duvernoy 		Clinical Cardiology 2005
Assessing progression or regression of CAD: The role of perfusion imaging
K Gould 		Journal of Nuclear Cardiology 2005
Effect of exercise training on endothelium-derived nitric oxide function in humans: Endothelial nitric oxide and exercise training
DJ Green, A Maiorana, G O'Driscoll, R Taylor 		The Journal of Physiology 2004
Coronary endothelial dysfunction is not rapidly reversible with ascorbic acid
ME Widlansky, ES Biegelsen, NM Hamburg, SJ Duffy, JF Keaney, JA Vita 		Free radical biology & medicine 2004
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation
MT Gladwin, JH Crawford, RP Patel 		Free radical biology & medicine 2004
Moderate Regular Exercise Increases Basal Production of Nitric Oxide in Elderly Women
S MAEDA, T TANABE, T OTSUKI, J SUGAWARA, M IEMITSU, T MIYAUCHI, S KUNO, R AJISAKA, M MATSUDA 		Hypertension Research 2004
The role of coronary endothelial function testing in patients suspected for angina pectoris
SH Monnink, RA Tio, AJ Boven, WH Gilst, DJ Veldhuisen 		International Journal of Cardiology 2004
Endothelial cell function testing: how does the method help us in evaluating vascular status?
JP Halcox, JE Deanfield 		Acta Paediatrica 2004
Plasma level of oxidized low-density lipoprotein is an independent determinant of coronary macrovasomotor and microvasomotor responses induced by bradykinin
T Matsumoto, H Takashima, N Ohira, Y Tarutani, Y Yasuda, T Yamane, S Matsuo, M Horie 		Journal of the American College of Cardiology 2004
Emerging role of nitrite in human biology
A Dejam, CJ Hunter, AN Schechter, MT Gladwin 		Blood Cells, Molecules, and Diseases 2004
Noninvasive interrogation of microvasculature for signs of endothelial dysfunction in patients with chronic renal failure
J Stewart, A Kohen, D Brouder, F Rahim, S Adler, R Garrick, MS Goligorsky 		American journal of physiology. Heart and circulatory physiology 2004
The Role of Nitric Oxide in Heart Failure
BI Jugdutt 		2004
Nitric oxide's reactions with hemoglobin: a view through the SNO-storm
MT Gladwin, JR Lancaster, BA Freeman, AN Schechter 		Nature Medicine 2003
Nitric oxide, atherosclerosis and the clinical relevance of endothelial dysfunction
Todd J Anderson 		Heart Failure Reviews 2003
Asymmetrical dimethylarginine: A novel risk factor for coronary artery disease
TM Lu, YA Ding, MJ Charng, SJ Lin 		Clinical Cardiology 2003
Exercise and the Nitric Oxide Vasodilator System
A Maiorana, G O???Driscoll, R Taylor, D Green 		Sports Medicine 2003
An emerging role for nitric oxide in sickle cell disease vascular homeostasis and therapy
CD Reiter, MT Gladwin 		Current Opinion in Hematology 2003
Complex disease genetics enters the high street
SC Bain, JD Rippin 		European Journal of Clinical Investigation 2003
Significance of Asymmetric Dimethylarginine (ADMA) Concentrations During Coronary Circulation in Patients With Vasospastic Angina
T Hori, T Matsubara, T Ishibashi, K Ozaki, K Tsuchida, T Mezaki, T Tanaka, A Nasuno, K Kubota, Y Nakamura, M Yamazoe, Y Aizawa, M Nishio 		Circulation Journal 2003
Despite In Vitro Increase in Cyclic Guanosine Monophosphate Concentrations, Intracarotid Nitroprusside Fails to Augment Cerebral Blood Flow of Healthy Baboons
S Joshi, R Hartl, LS Sun, AD Libow, M Wang, J Pile-Spellman, WL Young, ES Connolly, CA Hirshman 		Anesthesiology 2003
Hemoglobin Solutions and Tissue Oxygenation
WW Muir, ML Wellman 		Journal of Veterinary Internal Medicine 2003
Leptin Causes Nitric-Oxide Independent Coronary Artery Vasodilation in Humans
K MATSUDA, H TERAGAWA, Y FUKUDA, K NAKAGAWA, Y HIGASHI, K CHAYAMA 		Hypertension Research 2003
Plasminogen activator inhibitor contributes to the coronary wall thickening in patients with angiographically normal coronary
Y Miyao, K Fujimoto, K Kugiyama, H Kawano, N Hirai, S Sugiyama, T Sakamoto, M Yoshimura, H Ogawa 		Thrombosis Research 2003
Endothelial function, inflammation, and prognosis in cardiovascular disease
MA Gonzalez, AP Selwyn 		The American Journal of Medicine 2003
Effect of plasminogen activator inhibitor–1 in diabetes mellitus and cardiovascular disease
CJ Lyon, WA Hsueh 		The American Journal of Medicine 2003
Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude
JT Kuvin, AR Patel, KA Sliney, NG Pandian, J Sheffy, RP Schnall, RH Karas, JE Udelson 		American Heart Journal 2003
Genetic influence on cigarette-induced cardiovascular disease
XL Wang, M Raveendran, J Wang 		Progress in Cardiovascular Diseases 2003
Exercise and the nitric oxide vasodilator system
A Maiorana, G O'Driscoll, R Taylor, D Green 		Sports Medicine 2003
Síndrome X cardiovascular y disfunción endotelial
E Vázquez-Rey, JC Kaski 		Revista Española de Cardiología 2003
Case report: Dexatrim (Phenylpropanolamine) as a cause of myocardial infarction
FH Pilsczek, AA Karcic, I Freeman 		Heart & Lung: The Journal of Acute and Critical Care 2003
Oral L-arginine improves endothelial function in healthy individuals older than 70 years
SM Bode-Böger, J Muke, A Surdacki, G Brabant, RH Böger, JC Frölich 		Vascular medicine (London, England) 2003
Coronary blood flow regulation in exercising swine involves parallel rather than redundant vasodilator pathways
D Merkus, DB Haitsma, TY Fung, YJ Assen, PD Verdouw, DJ Duncker 		American journal of physiology. Heart and circulatory physiology 2003
Clinical Importance of Endothelial Function in Arteriosclerosis and Ischemic Heart Disease
K Egashira 		Circulation Journal 2002
Amlodipine, but not verapamil or nifedipine, dilates rabbit femoral artery largely through a nitric oxide- and kinin-dependent mechanism
B Xu, L Xiao-hong, G Lin, L Queen, A Ferro 		British Journal of Pharmacology 2002
Coronary Endothelium-Dependent and Independent Vasomotor Responses in Patients With Hypertrophic Cardiomyopathy
H Yokohama, T Matsumoto, H Horie, K Minai, M Kinoshita 		Circulation Journal 2002
Oral L-arginine (and other active ingredients) for ischemic heart disease?∗∗Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology
RO Cannon 		Journal of the American College of Cardiology 2002
Randomized trial of a medical food for the dietary management of chronic, stable angina
AJ Maxwell, MP Zapien, GL Pearce, G MacCallum, PH Stone 		Journal of the American College of Cardiology 2002
Early Benefits of Pravastatin to Experimentally Induced Atherosclerosis
EP Silva, FA Fonseca, SS Ihara, MC Izar, IL Lopes, LE Pinto, JJ Badimon, S Tuffik, TB Paiva, N Kasinski, AV de Paola, AC Carvalho 		Journal of Cardiovascular Pharmacology 2002
Coexistence of Impairment of Endothelium-Derived Nitric Oxide and Platelet-Derived Nitric Oxide in Patients With Coronary Risk Factors
A Katoh, H Ikeda, Y Takajo, N Haramaki, T Murohara, S Shintani, S Kanaya, S Yokoyama, T Ueno, T Honma, T Imaizumi 		Circulation Journal 2002
The effect of sildenafil on human vascular function, platelet activation, and myocardial ischemia
JP Halcox, KR Nour, G Zalos, R Mincemoyer, MA Waclawiw, CE Rivera, G Willie, S Ellahham, AA Quyyumi 		Journal of the American College of Cardiology 2002
Invasive assessment of the coronary circulation: intravascular ultrasound and Doppler
DE Newby, KA Fox 		British Journal of Clinical Pharmacology 2002
Lack of evidence for contribution of Glu298Asp (G894T) polymorphism of endothelial nitric oxide synthase gene to plasma nitric oxide levels
J Moon, S Yoon, E Kim, C Shin, SA Jo, I Jo 		Thrombosis Research 2002
Vasomotor and vascular effects of hormone replacement therapy
P Ganz 		The American Journal of Cardiology 2002
Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia
N Weiss, C Keller, U Hoffmann, J Loscalzo 		Vascular medicine (London, England) 2002
Plasminogen activator inhibitor-1 promotes formation of endothelial microparticles with procoagulant potential
SV Brodsky, K Malinowski, M Golightly, J Jesty, MS Goligorsky 		Circulation 2002
Nitric oxide regulates local arterial distensibility in vivo
IB Wilkinson, A Qasem, CM McEniery, DJ Webb, AP Avolio, JR Cockcroft 		Circulation 2002
Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure
MA Forgione, A Cap, R Liao, NI Moldovan, RT Eberhardt, CC Lim, J Jones, PJ Goldschmidt-Clermont, J Loscalzo 		Circulation 2002
Smoking status-dependent association of the 27-bp repeat polymorphism in intron 4 of endothelial nitric oxide synthase gene with plasma nitric oxide concentrations
S Yoon, J Moon, C Shin, E Kim, SA Jo, I Jo 		Clinica Chimica Acta 2002
Acute inhibition of glutathione biosynthesis alters endothelial function and blood pressure in rats
AA Ganafa, RR Socci, D Eatman, N Silvestrova, IK Abukhalaf, MA Bayorh 		European Journal of Pharmacology 2002
Endothelial dysfunction in patients with coronary artery disease: a comparison of three frequently reported tests
Stefan H J Monnink, Paul L van Haelst, Ad J van Boven, Erik S G Stroes, René A Tio, Thijs W M Plokker, Andries J Smit, Nic J G M Veeger, Harry J G M Crijns, Wiek H van Gilst 		Journal of Investigative Medicine 2002
Safety evaluation of routine intracoronary acetylcholine infusion in patients undergoing a first diagnostic coronary angiogram
R A Tio, S H J Monnink, G Amoroso, G A J Jessurun, N Veeger, C Volkers, R Hautvast, E S Tan, W H van Gilst, A J van Boven 		Journal of Investigative Medicine 2002
Cellular glutathione peroxidase deficiency and endothelial dysfunction
MA Forgione, N Weiss, S Heydrick, A Cap, ES Klings, C Bierl, RT Eberhardt, HW Farber, J Loscalzo 		American journal of physiology. Heart and circulatory physiology 2002
Predisposition to Atherosclerosis by Infections: Role of Endothelial Dysfunction
A Prasad, J Zhu, JP Halcox, MA Waclawiw, SE Epstein, AA Quyyumi 		Circulation 2002
Prognostic Value of Coronary Vascular Endothelial Dysfunction
JP Halcox, WH Schenke, G Zalos, R Mincemoyer, A Prasad, MA Waclawiw, KR Nour, AA Quyyumi 		Circulation 2002
Pan Vascular Medicine
P Lanzer, EJ Topol 		2002
Women’s Health and Menopause
RA Lobo, PG Crosignani, R Paoletti, F Bruschi 		2002
Quinapril: A Further Update of its Pharmacology and Therapeutic Use in Cardiovascular Disorders
CR Culy, B Jarvis 		Drugs 2002
Nitric oxide inhalation effects on regional blood flow: Evidence for intravascular transport of bioactive nitric oxide
Richard O. Cannon III, Alan N. Schechter, Julio A. Panza, Frederick P. Ognibene, Margaret E. Pease-Fye, Myron A. Waclawiw, James H. Shelhamer, Mark T. Gladwin 		Journal of Clinical Investigation 2001
Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo
S Kaushal, GE Amiel, KJ Guleserian, OM Shapira, T Perry, FW Sutherland, E Rabkin, AM Moran, FJ Schoen, A Atala, S Soker, J Bischoff, JE Mayer 		Nature Medicine 2001
N-acetylcysteine improves coronary and peripheral vascular function
NP Andrews, A Prasad, AA Quyyumi 		Journal of the American College of Cardiology 2001
Polymorphisms in endothelial nitric oxide synthase and atherogenesis
AD Hingorani 		Atherosclerosis 2001
Chronic inhibition of NO synthesis per se promotes structural intimal remodeling of the rat aorta
MA Rossi, M Colombini-Netto 		Journal of Hypertension 2001
Pharmacological approaches to preserving and restoring coronary endothelial function
OL Woodman 		Expert Opinion on Pharmacotherapy 2001
l -Arginine for the prevention and treatment of coronary artery disease
A Blum, RO Cannon 		Coronary Artery Disease 2001
Coronary Vasomotor Responses to Bradykinin and Acetyl-choline in Patients With Coronary Spastic Angina
T Matsumoto, H Horie, K Minai, H Yokohama, H Takashima, N Ohira, T Tsutui, M Takahashi, M Kinoshita 		Japanese Circulation Journal 2001
Different Contribution of Endothelial Nitric Oxide in the Relaxation of Human Coronary Arteries of Ischemic and Dilated Cardiomyopathic Hearts
E Thorin 		Journal of Cardiovascular Pharmacology 2001
Influence of Nitric Oxide Synthase Inhibition and Endothelin-1 Receptor Blockade on Acetylcholine-Induced Coronary Artery Contraction In Vitro in Dilated and Ischemic Cardiomyopathies
E Thorin 		Journal of Cardiovascular Pharmacology 2001
Functions of the healthy endothelium
RK Kharbanda, JE Deanfield 		Coronary Artery Disease 2001
The assessment of endothelial function in humans
HM Farouque, IT Meredith 		Coronary Artery Disease 2001
Coronary vascular endothelial function and myocardial ischemia: why should we worry about endothelial dysfunction?
JP Halcox, AA Quyyumi 		Coronary Artery Disease 2001
Platelet inhibitory effect of nitric oxide in the human coronary circulation: impact of endothelial dysfunction
NP Andrews, M Husain, N Dakak, AA Quyyumi 		Journal of the American College of Cardiology 2001
Magnesium causes nitric oxide independent coronary artery vasodilation in humans
H Teragawa, M Kato, T Yamagata, H Matsuura, G Kajiyama 		Heart (British Cardiac Society) 2001
Glutathione attenuates coronary constriction to acetylcholine in patients with coronary spastic angina
K Kugiyama, Y Miyao, T Sakamoto, H Kawano, H Soejima, S Miyamoto, M Yoshimura, H Ogawa, S Sugiyama, H Yasue 		American journal of physiology. Heart and circulatory physiology 2001
Mejoría de la función endotelial al reducir las concentraciones lipídicas en pacientes con hipercolesterolemia y arterias coronarias normales
X Pintó, X Palom, Á Cequier, E Iràculis, M Sabaté, JA Gómez-Hospital, J Mauri, BG Blanco, E Fernández-Nofrerias, F Jara, E Esplugas 		Revista Española de Cardiología 2001
Muscarinic receptors in the Mammalian Heart
S Dhein, CJ van Koppen, OE Brodde 		Pharmacological Research 2001
Nitric oxide therapy in sickle cell disease
M T Gladwin, A N Schechter 		Seminars in Hematology 2001
L-NAME, A NITRIC OXIDE SYNTHASE INHIBITOR, AS A POTENTIAL COUNTERMEASURE TO POST-SUSPENSION HYPOTENSION IN RATS
MA Bayorh, RR Socci, S Watts, M Wang, D Eatman, N Emmett, M Thierry-Palmer 		Clinical and Experimental Hypertension 2001
Integrin-binding peptides containing RGD produce coronary arteriolar dilation via cyclooxygenase activation
TW Hein, SH Platts, KR Waitkus-Edwards, L Kuo, SA Mousa, GA Meininger 		American journal of physiology. Heart and circulatory physiology 2001
Mechanism of Endothelial Dysfunction in Apolipoprotein E–Deficient Mice
LV dUscio, TA Baker, CB Mantilla, L Smith, D Weiler, GC Sieck, ZS Katusic 		Arteriosclerosis, thrombosis, and vascular biology 2001
Association Between Polymorphism in the Chemokine Receptor CX3CR1 and Coronary Vascular Endothelial Dysfunction and Atherosclerosis
DH McDermott, JP Halcox, WH Schenke, MA Waclawiw, MN Merrell, N Epstein, AA Quyyumi, PM Murphy 		Circulation research 2001
Workshop: Endothelial Cell Dysfunction Leading to Diabetic Nephropathy: Focus on Nitric Oxide
MS Goligorsky, J Chen, S Brodsky 		Hypertension 2001
Regulation of the coronary vasomotor tone: What we know and where we need to go
E Toyota 		Journal of Nuclear Cardiology 2001
Endothelial cell dysfunction and nitric oxide synthase
MS Goligorsky 		Kidney International 2000
Diffuse intimal thickening of coronary arteries in patients with coronary spastic angina
Y Miyao, K Kugiyama, H Kawano, T Motoyama, H Ogawa, M Yoshimura, T Sakamoto, H Yasue 		Journal of the American College of Cardiology 2000
Diffuse coronary artery disease and endothelial dysfunction: form follows function
J Cooke 		ACC Current Journal Review 2000
Tetrahydrobiopterin Improves Endothelial Function in Patients with Coronary Artery Disease
W Maier, F Cosentino, RB Lütolf, M Fleisch, C Seiler, OM Hess, B Meier, TF Lüscher 		Journal of Cardiovascular Pharmacology 2000
The insertion/deletion polymorphism of the angiotensin-converting enzyme gene determines coronary vascular tone and nitric oxide activity
A Prasad, S Narayanan, MA Waclawiw, N Epstein, AA Quyyumi 		Journal of the American College of Cardiology 2000
Decrease of Nitric Oxide End-products during Coronary Circulation Reflects Elevated Basal Coronary Artery Tone in Patients with Vasospastic Angina
T Hori, T Matsubara, T Ishibashi, M Yamazoe, T Ida, K Higuchi, M Takemoto, S Ochiai, Y Tamura, Y Aizawa, M Nishio 		Japanese Heart Journal 2000
Role of nitric oxide in vascular tone and in reactivity to isoproterenol and adenosine in the goat coronary circulation
N Fernández, MA Sánchez, MA Martı́nez, AL Garcı́a-Villalón, L Monge, B Gómez, G Diéguez 		European Journal of Pharmacology 2000
Cardiovascular Effects Of Chronic Nitric Oxide Synthase Inhibition In Genetically Hypertensive Rats
SJ Orange, JM Ledingham, R Laverty 		Clinical and Experimental Pharmacology and Physiology 2000
Intracarotid Infusion of the Nitric Oxide Synthase Inhibitor, l-NMMA, Modestly Decreases Cerebral Blood Flow in Human Subjects
S Joshi, WL Young, DH Duong, ND Ostapkovich, BD Aagaard, T Hashimoto, J Pile-Spellman 		Anesthesiology 2000
Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans
MT Gladwin, JH Shelhamer, AN Schechter, ME Pease-Fye, MA Waclawiw, JA Panza, FP Ognibene, RO 3rd 		Proceedings of the National Academy of Sciences 2000
Platelets
JN George 		The Lancet 2000
Endothelial Nitric Oxide Synthase Gene Sequence Variations and Vascular Disease
XL Wang, J Wang 		Molecular Genetics and Metabolism 2000
The preferred source of arginine for high-output nitric oxide synthesis in blood vessels
L Xie, Y Hattori, N Tume, SS Gross 		Seminars in Perinatology 2000
Relation between endothelial dysfunction and the acute coronary syndrome: implications for therapy
S Kinlay, P Ganz 		The American Journal of Cardiology 2000
Ascorbic acid and glutathione modulate the biological activity of S-nitrosoglutathione
A Xu, JA Vita, JF Keaney 		Hypertension 2000
Contractile effects of arginine analogues on human internal thoracic and radial arteries
G Segarra, P Medina, JM Vila, JB Martínez-León, RM Ballester, P Lluch, S Lluch 		The Journal of Thoracic and Cardiovascular Surgery 2000
Platelet-derived nitric oxide and coronary risk factors
H Ikeda, Y Takajo, T Murohara, K Ichiki, H Adachi, N Haramaki, A Katoh, T Imaizumi 		Hypertension 2000
Contribution of bradykinin receptor dysfunction to abnormal coronary vasomotion in humans
A Prasad, S Husain, W Schenke, R Mincemoyer, N Epstein, A A Quyyumi 		Journal of the American College of Cardiology 2000
Inhibition of nitric oxide synthase enhances the myocardial toxicity of phenylpropanolamine:
GP Zaloga, JD Clark, PR Roberts 		Critical Care Medicine 2000
Increased aortic stiffness assessed by pulse wave velocity in apolipoprotein E-deficient mice
YX Wang, M Halks-Miller, R Vergona, ME Sullivan, R Fitch, C Mallari, B Martin-McNulty, V Cunha, A Freay, GM Rubanyi, K Kauser 		American journal of physiology. Heart and circulatory physiology 2000
ox LDL specifically impairs endothelium-dependent, NO-mediated dilation of coronary arterioles
TW Hein, JC Liao, L Kuo 		American journal of physiology. Heart and circulatory physiology 2000
Relationship Between Plasma Oxidized Low-Density Lipoprotein and the Coronary Vasomotor Response to Acetylcholine in Patients With Coronary Artery Disease
T Nakaishi, A Tamura, T Watanabe, Y Mikuriya, M Nasu 		Japanese Circulation Journal 2000
Effects of homocysteine on endothelial nitric oxide production
X Zhang, H Li, H Jin, Z Ebin, S Brodsky, MS Goligorsky 		American journal of physiology. Renal physiology 2000
Vasodilator mechanisms in the coronary circulation of endothelial nitric oxide synthase-deficient mice
KG Lamping, DW Nuno, EG Shesely, N Maeda, FM Faraci 		American journal of physiology. Heart and circulatory physiology 2000
Role of pertussis toxin-sensitive G protein in metabolic vasodilation of coronary microcirculation
T Tanikawa, H Kanatsuka, R Koshida, M Tanaka, A Sugimura, T Kumagai, M Miura, T Komaru, K Shirato 		American journal of physiology. Heart and circulatory physiology 2000
Endothelial dysfunction and peroxynitrite formation are early events in angiotensin-induced cardiovascular disorders
SK Wattanapitayakul, DA Weinstein, BJ Holycross, JA Bauer 		The FASEB Journal 2000
Insertion-Deletion Polymorphism of the ACE Gene Modulates Reversibility of Endothelial Dysfunction With ACE Inhibition
A Prasad, S Narayanan, S Husain, F Padder, M Waclawiw, N Epstein, AA Quyyumi 		Circulation 2000
Prognostic Impact of Coronary Vasodilator Dysfunction on Adverse Long-Term Outcome of Coronary Heart Disease
V Schächinger, MB Britten, AM Zeiher 		Circulation 2000
Oral l -Arginine in Patients With Coronary Artery Disease on Medical Management
A Blum, L Hathaway, R Mincemoyer, WH Schenke, M Kirby, G Csako, MA Waclawiw, JA Panza, RO Cannon 		Circulation 2000
Cardiovascular Benefit of Cholesterol-Lowering Therapy: Does Improved Endothelial Vasodilator Function Matter?
RO Cannon 		Circulation 2000
Lipoprotein Lipase Activity Is Associated With Severity of Angina Pectoris
JJ Kastelein, JW Jukema, AH Zwinderman, S Clee, AJ van Boven, H Jansen, TJ Rabelink, RJ Peters, KI Lie, G Liu, AV Bruschke, MR Hayden 		Circulation 2000
Effect of Cholesterol-Lowering Therapy on Coronary Endothelial Vasomotor Function in Patients With Coronary Artery Disease
JA Vita, AC Yeung, M Winniford, JM Hodgson, CB Treasure, JL Klein, S Werns, M Kern, D Plotkin, WJ Shih, Y Mitchel, P Ganz 		Circulation 2000
Herzkatheter
OM Hess, RW Simon 		2000
Oxidative Stress and Vascular Disease
JF Keaney 		2000
Effect of -arginine administration on myocardial thallium-201 perfusion during exercise in patients with angina pectoris and normal coronary angiograms
H Fujita 		Journal of Nuclear Cardiology 2000
The role of myocardial perfusion imaging in vascular endothelial dysfunction
V Dilsizian 		Journal of Nuclear Cardiology 2000
Natural Antioxidants and Anticarcinogens in Nutrition, Health and Disease
D Bagchi, RL Krohn, J Balmoori, M Bagchi, A Garg, SJ Stohs 		Natural Antioxidants and Anticarcinogens in Nutrition, Health and Disease 1999
Glutathione reverses endothelial dysfunction and improves nitric oxide bioavailability
A Prasad, NP Andrews, FA Padder, M Husain, AA Quyyumi 		Journal of the American College of Cardiology 1999
New insights into nitric oxide and coronary circulation
D Gattullo, P Pagliaro, NA Marsh, G Losano 		Life Sciences 1999
L-arginine: a novel therapy for coronary artery disease?
JL Velianou, JA Suwaidi, A Lerman 		Expert Opinion on Investigational Drugs 1999
Relationship of the C242Tp22phox gene polymorphism to angiographic coronary artery disease and endothelial function
A Li, A Prasad, R Mincemoyer, C Satorius, N Epstein, T Finkel, AA Quyyumi 		American Journal of Medical Genetics 1999
Paradoxical increase in coronary flow velocity after termination of acetylcholine infusion is a marker of the impaired vasodilatation at coronary microvessels in patients with angina and normal coronary arteries
M Takeuchi, Y Nohtomi, A Kuroiwa 		Catheterization and Cardiovascular Interventions 1999
Endothelium-derived nitric oxide enhances the effect of intraaortic balloon pumping on diastolic coronary flow
E Toyota, M Goto, H Nakamoto, J Ebata, H Tachibana, O Hiramatsu, Y Ogasawara, F Kajiya 		The Annals of Thoracic Surgery 1999
Changes in Endothelium-Derived Vascular Regulatory Factors During Dobutamine-Stress-Induced Silent Myocardial Ischemia in Patients With Kawasaki Disease
Y Hino, T Ohkubo, Y Katsube, S Ogawa 		Japanese Circulation Journal 1999
Endothelial Dysfunction in Hypertension
W Kiowski 		Clinical and Experimental Hypertension 1999
Effect of cholesterol lowering treatment on positive exercise tests in patients with hypercholesterolaemia and normal coronary angiograms
AP Mansur, CV Serrano, JC Nicolau, LA César, JA Ramires 		Heart (British Cardiac Society) 1999
Assessment and treatment of endothelial dysfunction in humans
TJ Anderson 		Journal of the American College of Cardiology 1999
Mechanism by which quinapril improves vascular function in coronary artery disease
KK Koh, MN Bui, L Hathaway, G Csako, MA Waclawiw, JA Panza, RO Cannon 		The American Journal of Cardiology 1999
Effect of enalaprilat on nitric oxide activity in coronary artery disease
A Prasad, S Husain, A A Quyyumi 		The American Journal of Cardiology 1999
Abnormal flow-mediated epicardial vasomotion in human coronary arteries is improved by angiotensin-converting enzyme inhibition: a potential role of bradykinin
A Prasad, S Husain, A A Quyyumi 		Journal of the American College of Cardiology 1999
Clinical importance of coronary endothelial vasodilator dysfunction and therapeutic options
M Britten, A Zeiher, V Schachinger 		Journal of Internal Medicine 1999
NO from smooth muscle cells decreases NOS expression in endothelial cells: role of TNF-α
T Frutos, LS de Miguel, M García-Durán, F González-Fernández, JA Rodríguez-Feo, M Montón, J Guerra, J Farré, S Casado, A López-Farré 		American journal of physiology. Heart and circulatory physiology 1999
Estrogen improves acetylcholine-induced but not metabolic vasodilation in biological males
G New, SJ Duffy, RW Harper, IT Meredith 		American journal of physiology. Heart and circulatory physiology 1999
Vitamin E and vascular homeostasis: implications for atherosclerosis
JF Keaney, DI Simon, JE Freedman 		The FASEB Journal 1999
Coronary Microvascular Disease in Humans
M MOHRI, A TAKESHITA 		Japanese Heart Journal 1999
Is It All in the Genes… ?: Nitric Oxide Synthase and Coronary Vasospasm
TF Lüscher, G Noll 		Circulation 1999
Endogenous Nitric Oxide Synthase Inhibitor: A Novel Marker of Atherosclerosis
H Miyazaki, H Matsuoka, JP Cooke, M Usui, S Ueda, S Okuda, T Imaizumi 		Circulation 1999
Contribution of Vasodilator Prostanoids and Nitric Oxide to Resting Flow, Metabolic Vasodilation, and Flow-Mediated Dilation in Human Coronary Circulation
SJ Duffy, SF Castle, RW Harper, IT Meredith 		Circulation 1999
Chest Pain with Normal Coronary Angiograms: Pathogenesis, Diagnosis and Management
JC Kaski 		1999
Enhanced Nitric Oxide–Mediated Vascular Relaxation in Radial Artery Compared With Internal Mammary Artery or Saphenous Vein
OM Shapira, A Xu, GS Aldea, JA Vita, RJ Shemin, JF Keaney 		Circulation 1999
Bedeutung der Endothelfunktion für ischämische Manifestationen der koronaren Atherosklerose
M Britten, V Schächinger 		Herz 1998
Therapeutische Optionen zur Verbesserung der Myokardperfusion bei koronarer Atherosklerose
V Schächinger 		Herz 1998
Methoden der funktionellen Koronardiagnostik
M Elsner 		Herz 1998
Endothelial Dysfunction and Coronary Risk Reduction
S Charo, N Gokce, JA Vita 		Journal of Cardiopulmonary Rehabilitation 1998
The role of endothelium in human hypertension
S Taddei, A Virdis, L Ghiadoni, A Salvetti 		Current Opinion in Nephrology and Hypertension 1998
Does acute improvement of endothelial dysfunction in coronary artery disease improve myocardial ischemia?
AA Quyyumi 		Journal of the American College of Cardiology 1998
Assessing the coronary circulation in hypertension
BE Strauer, B Schwartzkopff, M Kelm 		Journal of Hypertension 1998
Heterogeneous Vasomotor Responses of Coronary Conduit and Resistance Vessels in Hypertension
JL Houghton, CA Davison, PA Kuhner, MT Torossov, DS Strogatz, AA Carr 		Journal of the American College of Cardiology 1998
Is nitroglycerin detrimental in patients with coronary artery ectasia? A case report
S Sanyal, N Caccavo 		Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital 1998
Coronary Vascular Responsiveness to Adenosine Is Impaired Additively by Blockade of Nitric Oxide Synthesis and a Sulfonylurea
CA Davis, AJ Sherman, Y Yaroshenko, S Hedjbeli, MA Parker, FJ Klocke 		Journal of the American College of Cardiology 1998
Impact of Coronary Risk Factors on Contribution of Nitric Oxide and Adenosine to Metabolic Coronary Vasodilation in Humans
T Minamino, M Kitakaze, Y Matsumura, K Nishida, Y Kato, K Hashimura, Y Matsu-ura, H Funaya, H Sato, T Kuzuya, M Hori 		Journal of the American College of Cardiology 1998
Potential mechanisms for the effect of angiotensin-converting enzyme inhibitors on endothelial dysfunction: the role of nitric oxide
RO Cannon 		The American Journal of Cardiology 1998
Role of nitric oxide in coronary arterial vasomotion and the influence of coronary atherosclerosis and its risks
DM Goodhart, TJ Anderson 		The American Journal of Cardiology 1998
Endothelial function in health and disease: new insights into the genesis of cardiovascular disease
AA Quyyumi 		The American Journal of Medicine 1998
Comparison of coronary endothelial dynamics with electrocardiographic and left ventricular contractile responses to stress in the absence of coronary artery disease
RO Cannon, RV Curiel, A Prasad, AA Quyyumi, JA Panza 		The American Journal of Cardiology 1998
Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina
K Kugiyama, T Motoyama, O Hirashima, M Ohgushi, H Soejima, K Misumi, H Kawano, Y Miyao, M Yoshimura, H Ogawa, T Matsumura, S Sugiyama, H Yasue 		Journal of the American College of Cardiology 1998
Association of remnant lipoprotein levels with impairment of endothelium-dependent vasomotor function in human coronary arteries
K Kugiyama, H Doi, T Motoyama, H Soejima, K Misumi, H Kawano, O Nakagawa, M Yoshimura, H Ogawa, T Matsumura, S Sugiyama, T Nakano, K Nakajima, H Yasue 		Circulation 1998
Regulation of the Cerebral Circulation: Role of Endothelium and Potassium Channels
FM Faraci, DD Heistad 		Physiological reviews 1998
Contribution of Nitric Oxide to Reactive Hyperemia: Impact of Endothelial Dysfunction
N Dakak, S Husain, D Mulcahy, NP Andrews, JA Panza, M Waclawiw, W Schenke, AA Quyyumi 		Hypertension 1998
Effect of Atherosclerosis on Endothelium-Dependent Inhibition of Platelet Activation in Humans
JG Diodati, N Dakak, DM Gilligan, AA Quyyumi 		Circulation 1998
Intracoronary Infusion of Reduced Glutathione Improves Endothelial Vasomotor Response to Acetylcholine in Human Coronary Circulation
K Kugiyama, M Ohgushi, T Motoyama, O Hirashima, H Soejima, K Misumi, M Yoshimura, H Ogawa, S Sugiyama, H Yasue 		Circulation 1998
Aspirin Improves Endothelial Dysfunction in Atherosclerosis
S Husain, NP Andrews, D Mulcahy, JA Panza, AA Quyyumi 		Circulation 1998
Advanced Imaging In Coronary Artery Disease
EE Wall, PK Blanksma, MG Niemeyer, W Vaalburg, HJ Crijns 		1998
Role of nitric oxide in cardiovascular disease: focus on the endothelium
RO Cannon 		Clinical chemistry 1998
Tetrahydrobiopterin restores endothelial function in hypercholesterolemia
E Stroes, J Kastelein, F Cosentino, W Erkelens, R Wever, H Koomans, T Lüscher, T Rabelink 		Journal of Clinical Investigation 1997
Plasma nitrite/nitrate level is inversely correlated with plasma low-density lipoprotein cholesterol level
S Tanaka, A Yashiro, M Ikeda, A Kuroiwa, Y Nakashima, H Nanri 		Clinical Cardiology 1997
Bradykinin-Induced Vasodilation of Human Coronary Arteries In Vivo: Role of Nitric Oxide and Angiotensin-Converting Enzyme
T Kuga, M Mohri, K Egashira, Y Hirakawa, T Tagawa, H Shimokawa, A Takeshita 		Journal of the American College of Cardiology 1997
Autacoids Mediate Coronary Vasoconstriction Induced by Nitric Oxide Synthesis Inhibition
S Pomposiello, XP Yang, YH Liu, M Surakanti, NE Rhaleb, M Sevilla, OA Carretero 		Journal of Cardiovascular Pharmacology 1997
Bradykinin induced dilatation of human epicardial and resistance coronary arteries in vivo: effect of inhibition of nitric oxide synthesis
M Kato, N Shiode, T Yamagata, H Matsuura, G Kajiyama 		Heart (British Cardiac Society) 1997
Nitric Oxide Activity in the Atherosclerotic Human Coronary Circulation
AA Quyyumi, N Dakak, D Mulcahy, NP Andrews, S Husain, JA Panza, RO Cannon 		Journal of the American College of Cardiology 1997
Effect of l-Arginine on Human Coronary Endothelium-Dependent and Physiologic Vasodilation
AA Quyyumi, N Dakak, JG Diodati, DM Gilligan, JA Panza, RO Cannon 		Journal of the American College of Cardiology 1997
Nitric Oxide-Mediated Flow-Dependent Dilation Is Impaired in Coronary Arteries in Patients With Coronary Spastic Angina
KK MD, MO MD, TM MD, SS MD, HO MD, MY MD, YI MD, OH MD, HK MD, HS MD, HY MD 		Journal of the American College of Cardiology 1997
Cell dysfunction in atherosclerosis and the ischemic manifestations of coronary artery disease
AP Selwyn, S Kinlay, M Creager, P Libby, P Ganz 		The American Journal of Cardiology 1997
Relation of pacing-induced coronary resistance vessel dilation to total serum cholesterol and heart rate-blood pressure product
TJ Anderson, DM Goodhart, M Traboulsi, ML Knudtson 		The American Journal of Cardiology 1997
Role of Endothelial Dysfunction in Coronary Artery Disease
JA MD 		The American Journal of Cardiology 1997
Supersensitive Dilator Response to Nitroglycerin But Not to Atrial Natriuretic Peptide in Spastic Coronary Arteries in Coronary Spastic Angina
KK MD, MO MD, SS MD, TM MD, HK MD, OH MD, HY MD 		The American Journal of Cardiology 1997
Coronary Segmental Responses to Acetylcholine and Bradykinin in Patients With Atherosclerotic Risk Factors
MK MD, NS MD, TY MD, HM MD, GK MD 		The American Journal of Cardiology 1997
Coronary Microcirculation in Health and Disease Summary of an NHLBI Workshop
WM Chilian 		Circulation 1997
Role of Nitric Oxide in the Development of Vascular α 1 -Adrenoreceptor Desensitization and Pressure Diuresis in Conscious Rats
N Minami, Y Imai, H Nishiyama, K Abe 		Hypertension 1997
Basal Release of Nitric Oxide Is Decreased in the Coronary Circulation in Patients With Heart Failure
M Mohri, K Egashira, T Tagawa, T Kuga, H Tagawa, Y Harasawa, H Shimokawa, A Takeshita 		Hypertension 1997
Enhanced Endothelin-Mediated Coronary Vasoconstriction and Attenuated Basal Nitric Oxide Activity in Experimental Hypercholesterolemia
V Mathew, CR Cannan, VM Miller, DA Barber, D Hasdai, RS Schwartz, DR Holmes, A Lerman 		Circulation 1997
Intra-arterial Nitrovasodilators Do Not Increase Cerebral Blood Flow in Angiographically Normal Territories of Arteriovenous Malformation Patients
S Joshi, WL Young, J Pile-Spellman, P Fogarty-Mack, RR Sciacca, L Hacein-Bey, H Duong, Y Vulliemoz, N Ostapkovich, T Jackson 		Stroke; a journal of cerebral circulation 1997
The Role of Nitric Oxide in Coronary Vascular Effects of Estrogen in Postmenopausal Women
V Guetta, AA Quyyumi, A Prasad, JA Panza, M Waclawiw, RO Cannon 		Circulation 1997
Coronary Vascular Nitric Oxide Activity in Hypertension and Hypercholesterolemia: Comparison of Acetylcholine and Substance P
AA Quyyumi, D Mulcahy, NP Andrews, S Husain, JA Panza, RO Cannon 		Circulation 1997
Genetic Contribution of the Endothelial Constitutive Nitric Oxide Synthase Gene to Plasma Nitric Oxide Levels
XL Wang, MC Mahaney, AS Sim, J Wang, J Wang, J Blangero, L Almasy, RB Badenhop, DE Wilcken 		Arteriosclerosis, thrombosis, and vascular biology 1997
Coronary Microcirculation in Health and Disease: Summary of an NHLBI Workshop
WM Chilian 		Circulation 1997
Endothelial Dysfunction in Essential Hypertension
JA Panza 		Clinical Cardiology 1997
Deficiency in nitric oxide bioactivity in epicardial coronary arteries of cigarette smokers
K Kugiyama, H Yasue, M Ohgushi, T Motoyama, H Kawano, Y Inobe, O Hirashima, S Sugiyama 		Journal of the American College of Cardiology 1996
Nitroglycerin-induced coronary vasodilation is not enhanced in patients with impaired endothelium-dependent dilation
TJ Anderson, IT Meredith, F Charbonneau, AC Yeung, M Dyce, AP Selwyn, P Ganz 		Journal of the American College of Cardiology 1996
Basal release of endothelium-derived nitric oxide at site of spasm in patients with variant angina
K Egashira, Y Katsuda, M Mohri, T Kuga, T Tagawa, H Shimokawa, A Takeshita 		Journal of the American College of Cardiology 1996
Origins of coronary artery ectasia
VL Sorrell, MJ Davis, AA Bove 		The Lancet 1996
Pathogenetic mechanisms of atherosclerosis: effect of lipid lowering on the biology of atherosclerosis
P Ganz, MA Creager, JC Fang, MV McConnell, R T.Lee, P Libby, AP Selwyn 		The American Journal of Medicine 1996
The Endothelium and the Coronary Circulation
FJ Klocke, G Srinivasan 		ACC Current Journal Review 1996
Effects of l -Arginine Supplementation on Endothelium-Dependent Coronary Vasodilation in Patients With Angina Pectoris and Normal Coronary Arteriograms
K Egashira, Y Hirooka, T Kuga, M Mohri, A Takeshita 		Circulation 1996
Nitric Oxide Activity Is Deficient in Spasm Arteries of Patients With Coronary Spastic Angina
K Kugiyama, H Yasue, K Okumura, H Ogawa, K Fujimoto, K Nakao, M Yoshimura, T Motoyama, Y Inobe, H Kawano 		Circulation 1996
Triggering of Acute Coronary Syndromes
SN Willich, JE Muller 		1996
Alterations of coronary blood flow and myocardial perfusion in hypercholesterolaemia.
Schächinger V, Zeiher AM 		Heart (British Cardiac Society) 1996
Nitric Oxide
RA Schroeder, PC Kuo 		Anesthesia & Analgesia 1995
Report of the NHLBI Working Group on research in coronary heart disease in blacks: issues and challenges
CK Francis 		Journal of the National Medical Association 1995
Sympathetically mediated effects of mental stress on the cardiac microcirculation of patients with coronary artery disease
N Dakak, AA Quyyumi, G Eisenhofer, DS Goldstein, RO Cannon 		The American Journal of Cardiology 1995
Contribution of Nitric Oxide to Metabolic Coronary Vasodilation in the Human Heart
AA Quyyumi, N Dakak, NP Andrews, DM Gilligan, JA Panza, RO Cannon 		Circulation 1995

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