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Citations to this article

Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice.
Y Zhang, … , D M Stern, P P Nawroth
Y Zhang, … , D M Stern, P P Nawroth
Published September 1, 1994
Citation Information: J Clin Invest. 1994;94(3):1320-1327. https://doi.org/10.1172/JCI117451.
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Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice.

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Abstract

Meth-A sarcoma cells were stable transfected to overexpress (sense construct) or underexpress (antisense construct) tissue factor. In vitro, there was no difference in plating efficiency or growth between these cell lines. In vivo, tumor cells transfected to overexpress tissue factor grew more rapidly, and established larger and more vascularized tumors than control transfectants. Antisense transfectants grew the slowest and were the least vascularized. Anticoagulation of mice with warfarin did not alter the difference between these tumor lines. Tumor cells over-expressing tissue factor released more (compared with control transfectants) mitogenic activity for endothelial cells in parallel with enhanced transcription of vascular permeability factor/vascular endothelial cell growth factor (VEGF/VPF), and diminished transcription of thrombospondin (TSP2), a molecule with anti-angiogenic properties. Antisense tissue factor transfectants, while releasing the lowest amount of mitogenic activity, had increased thrombospondin and decreased VEGF/VPF transcription compared with control transfectants or wild-type cells. Experiments with these sense, antisense, truncated sense, or vector tumor lines gave comparable results in complete medium, serum free medium or in the presence of hirudin, indicating that the activation of the coagulation mechanism was not likely to be responsible for changes in tumor cell properties. These results suggest that tissue factor regulates angiogenic properties of tumor cells by altering the production of growth regulatory molecules of endothelium by a mechanism distinct from tissue factor activation of the coagulation mechanism.

Authors

Y Zhang, Y Deng, T Luther, M Müller, R Ziegler, R Waldherr, D M Stern, P P Nawroth

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F Elice, J Jacoub, FR Rickles, A Falanga, F Rodeghiero
American Journal of Hematology 2008
Tissue factor regulation by epidermal growth factor receptor and epithelial-to-mesenchymal transitions: effect on tumor initiation and angiogenesis
CC Milsom, JL Yu, N Mackman, J Micallef, GM Anderson, A Guha, JW Rak
Cancer research 2008
Use of mouse models to study the role of tissue factor in tumor biology
R Pawlinski, N Mackman
Seminars in thrombosis and hemostasis 2008
Tissue factor, angiogenesis and tumour progression
JE Bluff, NJ Brown, MW Reed, CA Staton
Breast Cancer Research 2008
Tissue factor/FVIIa activates Bcl-2 and prevents doxorubicin-induced apoptosis in neuroblastoma cells
J Fang, L Gu, N Zhu, H Tang, CS Alvarado, M Zhou
BMC Cancer 2008
Contribution of Host-Derived Tissue Factor to Tumor Neovascularization
J Yu, L May, C Milsom, GM Anderson, JI Weitz, JP Luyendyk, G Broze, N Mackman, J Rak
Arteriosclerosis, thrombosis, and vascular biology 2008
Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response
HE Kaiser, A Nasir
2008
Expression of Tissue Factor in Prostate Cancer Correlates With Malignant Phenotype
V Kaushal, P Mukunyadzi, ER Siegel, RA Dennis, DE Johnson, M Kohli
Applied Immunohistochemistry & Molecular Morphology 2008
Protease-Activated Receptor (PAR) 2, but not PAR1, Signaling Promotes the Development of Mammary Adenocarcinoma in Polyoma Middle T Mice
HH Versteeg, F Schaffner, M Kerver, LG Ellies, P Andrade-Gordon, BM Mueller, W Ruf
Cancer research 2008
Trousseau Syndrome Due to Pleural Mesothelioma
H Matsui, K Nishinaka, M Oda, T Kubori, F Udaka
The Neurologist 2007
Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation
C Kannemeier, A Shibamiya, F Nakazawa, H Trusheim, C Ruppert, P Markart, Y Song, E Tzima, E Kennerknecht, M Niepmann, ML Bruehl, D Sedding, S Massberg, A Günther, B Engelmann, KT Preissner
Proceedings of the National Academy of Sciences 2007
Inhibition of tissue factor signaling suppresses tumor growth
HH Versteeg, F Schaffner, M Kerver, HH Petersen, J Ahamed, B Felding-Habermann, Y Takada, BM Mueller, W Ruf
Blood 2007
Tissue factor expression as a possible determinant of thromboembolism in ovarian cancer
K Uno, S Homma, T Satoh, K Nakanishi, D Abe, K Matsumoto, A Oki, H Tsunoda, I Yamaguchi, T Nagasawa, H Yoshikawa, K Aonuma
British Journal of Cancer 2007
Cancer-associated thrombosis
JI Zwicker, BC Furie, B Furie
Critical Reviews in Oncology/Hematology 2007
Tissue factor and vascular endothelial growth factor expression in colorectal cancer: relation with cancer recurrence
DF Altomare, MT Rotelli, A Pentimone, MR Rossiello, E Martinelli, A Guglielmi, MD Fazio, F Marino, V Memeo, M Colucci, N Semeraro
Colorectal Disease 2007
CNTO 859, a humanized anti-tissue factor monoclonal antibody, is a potent inhibitor of breast cancer metastasis and tumor growth in xenograft models
CV Ngo, K Picha, F McCabe, H Millar, R Tawadros, SH Tam, MT Nakada, GM Anderson
International Journal of Cancer 2007
Prothrombotic effect of prostasomes of metastatic cell and seminal origin
AA Babiker, OA Hamad, J Sanchez, G Ronquist, B Nilsson, KN Ekdahl
The Prostate 2007
Fat poetry: a kingdom for PPARγ
SI Anghel, W Wahli
Cell Research 2007
Fibronectin-adherent monocytes express tissue factor and tissue factor pathway inhibitor whereas endotoxin-stimulated monocytes primarily express tissue factor: physiologic and pathologic implications
MS Bajaj, M Ghosh, SP Bajaj
Journal of Thrombosis and Haemostasis 2007
Redundant signaling of tissue factor and thrombin in cancer progression?
W Ruf
Journal of Thrombosis and Haemostasis 2007
Low molecular weight heparins in cancer patients: to treat thromboembolic events, the tumor, or both?
S Siragusa
Oncology Reviews 2007
Increase in expression of monocytic tissue factor (CD142) with monocytes and blood platelet activation in liver cirrhosis
A Panasiuk, J Zak, B Panasiuk, D Prokopowicz
Blood Coagulation & Fibrinolysis 2007
Tissue factor expression correlates with disease-specific survival in patients with node-negative muscle-invasive bladder cancer
G Patry, H Hovington, H Larue, F Harel, Y Fradet, L Lacombe
International Journal of Cancer 2007
The angiogenic switch occurs at the adenoma stage of the adenoma carcinoma sequence in colorectal cancer
CA Staton, AS Chetwood, IC Cameron, SS Cross, NJ Brown, MW Reed
Gut 2007
Heparanase, heparin and the coagulation system in cancer progression
I Vlodavsky, N Ilan, Y Nadir, B Brenner, BZ Katz, A Naggi, G Torri, B Casu, R Sasisekharan
Thrombosis Research 2007
The effects of low molecular weight heparins on venous thromboembolism and survival in patients with cancer
AY Lee
Thrombosis Research 2007
Tissue factor and PAR signaling in tumor progression
W Ruf
Thrombosis Research 2007
The role of tumor-and host-related tissue factor pools in oncogene-driven tumor progression
C Milsom, J Yu, L May, B Meehan, N Magnus, K Al-Nedawi, J Luyendyk, J Weitz, P Klement, G Broze, N Mackman, J Rak
Thrombosis Research 2007
A novel anti-tissue factor monoclonal antibody with anticoagulant potency derived from synthesized multiple antigenic peptide through blocking FX combination with TF
ZC Peng, X Cai, YG Zhang, DS Kong, HS Guo, W Liang, QQ Tang, HY Song, D Ma
Thrombosis Research 2007
Cancer-Associated Thrombosis: New Findings in Translational Science, Prevention, and Treatment
G Petralia, A Kakkar
Cancer-Associated Thrombosis: New Findings in Translational Science, Prevention, and Treatment 2007
Venous Thromboembolism and Cancer
D Bergqvist, JA Caprini, O Dotsenko, AK Kakkar, RG Mishra, TW Wakefield
Current Problems in Surgery 2007
Eosinophils are a major intravascular location for tissue factor storage and exposure
C Moosbauer, E Morgenstern, SL Cuvelier, D Manukyan, K Bidzhekov, S Albrecht, P Lohse, KD Patel, B Engelmann
Blood 2006
Elevation of plasma tissue factor levels in patients with severe acute pancreatitis
H Sawa, T Ueda, Y Takeyama, T Yasuda, N Matsumura, T Nakajima, T Ajiki, Y Fujino, Y Suzuki, Y Kuroda
Journal of Gastroenterology 2006
The pathogenesis of venous thromboembolism in cancer: emerging links with tumour biology
PC Winter
Hematological Oncology 2006
Heparanase induces tissue factor expression in vascular endothelial and cancer cells
Y Nadir, B Brenner, A Zetser, N Ilan, I Shafat, E Zcharia, O Goldshmidt, I Vlodavsky
Journal of Thrombosis and Haemostasis 2006
Grateloupia longifolia polysaccharide inhibits angiogenesis by downregulating tissue factor expression in HMEC-1 endothelial cells
C Zhang, F Yang, XW Zhang, SC Wang, MH Li, LP Lin, J Ding
British Journal of Pharmacology 2006
Low-molecular-weight heparins and angiogenesis
K Norrby
APMIS 2006
Identification and characterization of murine alternatively spliced tissue factor
VY Bogdanov, RI Kirk, C Miller, JJ Hathcock, S Vele, M Gazdoiu, Y Nemerson, MB Taubman
Journal of Thrombosis and Haemostasis 2006
VEGF Expression in Human Glioma Cells Treated with Tissue Factor and FVIIa
SB Smolik, G Powell
Journal of Neurosurgical Anesthesiology 2006
Evaluation of plasma tissue factor and tissue factor pathway inhibitor levels in childhood hemangiomas
M Türker, G İrken, H Ören, Ş Yılmaz, F Yüksel, N Olgun
Pediatric Blood & Cancer 2006
Tumour-expressed tissue factor inhibits cellular cytotoxicity
C Li, LM Colman, ME Collier, CE Dyer, J Greenman, C Ettelaie
Cancer Immunology, Immunotherapy 2006
Treatment of Cancer-Associated Thrombosis: Distinguishing Among Antithrombotic Agents
J Pruemer
Seminars in Oncology 2006
Circulating endothelial cells, endothelial progenitor cells, and endothelial microparticles in cancer
PK Goon, GY Lip, CJ Boos, PS Stonelake, AD Blann
Neoplasia (New York, N.Y.) 2006
Tissue factor and tumor: Clinical and laboratory aspects
Y Förster, A Meye, S Albrecht, B Schwenzer
Clinica Chimica Acta 2006
Expression of tissue factor in pancreatic adenocarcinoma is associated with activation of coagulation
SL Haas, R Jesnowski, M Steiner, F Hummel, J Ringel, C Burstein, H Nizze, S Liebe, JM Löhr
World journal of gastroenterology : WJG 2006
Thrombosis and Cancer: The Role of Screening for Occult Cancer and Recognizing the Underlying Biological Mechanisms
AY Lee
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2006
Ovarian cancer, the coagulation pathway, and inflammation
X Wang, E Wang, JJ Kavanagh, RS Freedman
Journal of Translational Medicine 2005
Angiostatin is a novel anti-inflammatory factor by inhibiting leukocyte recruitment
T Chavakis, A Athanasopoulos, JS Rhee, V Orlova, T Schmidt-Wöll, A Bierhaus, AE May, I Celik, PP Nawroth, KT Preissner
Blood 2005
Anti-thrombotics in thrombosis and cancer
SA Mousa
Future Oncology 2005
Pulmonary tumor thrombotic microangiopathy caused by a gastric carcinoma expressing vascular endothelial growth factor and tissue factor
K Chinen, T Kazumoto, Y Ohkura, O Matsubara, E Tsuchiya
Pathology International 2005
ANGIOGENESIS, CHOROIDAL NEOVASCULARIZATION, AND THE COAGULATION SYSTEM
GL Stoller, SA Mousa
Retina 2005
Angiogenesis: update 2005
HF Dvorak
Journal of Thrombosis and Haemostasis 2005
Radiotherapy of Human Xenograft NSCLC Tumors in Nude Mice with a90Y-Labeled Anti-Tissue Factor Antibody
B Wang, M Berger, G Masters, E Albone, Q Yang, J Sheedy, Y Kirksey, L Grimm, B Wang, J Singleton, D Soltis
Cancer Biotherapy & Radiopharmaceuticals 2005
Venous Thromboembolism in Patients with Cancer and Its Relationship to the Coagulation Cascade and Vascular Endothelial Growth Factor
M Dogan, A Demirkazik
Supportive Cancer Therapy 2005
Cancer Gene Therapy
M Yamamoto, DT Curiel
Technology in cancer research & treatment 2005
Tissue Factor–Factor VIIa Signaling
LV Rao, UR Pendurthi
Arteriosclerosis, thrombosis, and vascular biology 2005
New Mechanisms for Tissue-Selective Estrogen-Free Contraception
HB Croxatto, R Schürmann, U Fuhrmann, I Schellschmidt
2005
Mechanisms of Disease: the impact of antithrombotic therapy in cancer patients
GA Petralia, NR Lemoine, AK Kakkar
Nature clinical practice. Oncology 2005
Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF
M Guba, M Yezhelyev, ME Eichhorn, G Schmid, I Ischenko, A Papyan, C Graeb, H Seeliger, EK Geissler, KW Jauch, CJ Bruns
Blood 2005
Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis
JL Yu, L May, V Lhotak, S Shahrzad, S Shirasawa, JI Weitz, BL Coomber, N Mackman, JW Rak
Blood 2004
Manipulating angiogenesis in medicine
P Carmeliet
Journal of Internal Medicine 2004
Genetic dissection of tumor angiogenesis: are PlGF and VEGFR-1 novel anti-cancer targets?
A Luttun, M Autiero, M Tjwa, P Carmeliet
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2004
The prothrombotic state in cancer: pathogenic mechanisms
MD Cicco
Critical Reviews in Oncology/Hematology 2004
Pancreatic cancer and thromboembolic disease
AA Khorana, RL Fine
The Lancet Oncology 2004
Tissue factor in neutrophils: yes
S Nakamura, T Imamura, K Okamoto
Journal of Thrombosis and Haemostasis 2004
Downregulation of tissue factor by RNA interference in human melanoma LOX-L cells reduces pulmonary metastasis in nude mice
X Wang, M Wang, M Amarzguioui, F Liu, Ø Fodstad, H Prydz
International Journal of Cancer 2004
Circulating endothelial cells in cancer patients do not express tissue factor
LV Beerepoot, N Mehra, F Linschoten, AS Jorna, T Lisman, HM Verheul, EE Voest
Cancer Letters 2004
Tissue factor
CA Spek
Blood Coagulation & Fibrinolysis 2004
Reduction in Arthritis Severity and Modulation of Immune Function in Tissue Factor Cytoplasmic Domain Mutant Mice
YH Yang, P Hall, G Milenkovski, L Sharma, P Hutchinson, E Melis, P Carmeliet, P Tipping, E Morand
The American Journal of Pathology 2004
Tissue factor and cancer metastasis: the role of intracellular and extracellular signaling pathways
HH Versteeg, CA Spek, MP Peppelenbosch, DJ Richel
Molecular Medicine 2004
Antitumor and antimetastatic effect of warfarin and heparins
V Bobek, J Kovařík
Biomedicine & Pharmacotherapy 2004
Patogenia de la trombosis asociada a enfermedades neoplásicas: implicaciones terapéuticas
C López-Pedrera, N Barbarroja, F Velasco
Medicina Clínica 2004
Thrombosis and Cancer: A Case for Tissue Factor
M Donati, R Lorenzet
Thrombosis and Cancer 2004
Deep Vein Thrombosis and Malignancy: A Surgical Oncologist's Perspective
KP Yap, DR McCready
Asian Journal of Surgery 2004
Heparin is much more than just an anticoagulant
JR Day, RC Landis, KM Taylor
Journal of Cardiothoracic and Vascular Anesthesia 2004
Tumor necrosis factor activates CRE-binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells
JA Gustin, R Pincheira, LD Mayo, ON Ozes, KM Kessler, MR Baerwald, CK Korgaonkar, DB Donner
American journal of physiology. Cell physiology 2004
Cross-talk of Integrin α3β1 and Tissue Factor in Cell Migration
A Dorfleutner, E Hintermann, T Tarui, Y Takada, W Ruf
Molecular biology of the cell 2004
The Janus-faced nature of prostasomes: their pluripotency favours the normal reproductive process and malignant prostate growth
G Ronquist, BO Nilsson
Prostate Cancer and Prostatic Diseases 2004
Role of endogenous thrombin in tumor implantation, seeding, and spontaneous metastasis
L Hu, M Lee, W Campbell, R Perez-Soler, S Karpatkin
Blood 2004
Mathematical modeling of tumor-induced angiogenesis
NV Mantzaris, S Webb, HG Othmer
Journal of Mathematical Biology 2004
Role of the tissue factor pathway in synovial inflammation
N Busso, C Morard, R Salvi, V P�clat, A So
Arthritis & Rheumatism 2003
Tissue factor and thrombin mediate myocardial ischemia-reperfusion injury
AJ Chong, TH Pohlman, CR Hampton, A Shimamoto, N Mackman, ED Verrier
The Annals of Thoracic Surgery 2003
Antithrombotics in thrombosis and cancer
SA Mousa
Expert Review of Cardiovascular Therapy 2003
Acquired resistance to activated protein C in breast cancer patients
MR Nijziel, R Oerle, M Christella, LG Thomassen, EC van Pampus, K Hamuly��k, G Tans, J Rosing
British Journal of Haematology 2003
Hemoglobin induces the production and release of matrix metalloproteinase-9 from human malignant cells
FA Siddiqui, TF Siddiqui, JL Francis
Blood Coagulation & Fibrinolysis 2003
Tumor angiogenesis of non-small cell lung cancer
N Shijubo, H Kojima, M Nagata, T Ohchi, A Suzuki, S Abe, N Sato
Microscopy Research and Technique 2003
Antimetastatic effect of tinzaparin, a low-molecular-weight heparin
A Amirkhosravi, SA Mousa, M Amaya, JL Francis
Journal of Thrombosis and Haemostasis 2003
Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling
DK Strickland, S Ranganathan
Journal of Thrombosis and Haemostasis 2003
From Trousseau to targeted therapy: new insights and innovations in thrombosis and cancer
MN Levine, AY Lee, AK Kakkar
Journal of Thrombosis and Haemostasis 2003
Tissue specific expression and serum levels of human tissue factor in patients with urological cancer
Y Förster, A Meye, S Albrecht, M Kotzsch, S Füssel, MP Wirth, B Schwenzer
Cancer Letters 2003
An expanding role for antithrombotic therapy in cancer patients
AK Kakkar
Cancer Treatment Reviews 2003
Tissue factor expression and prognosis in patients with metastatic prostate cancer
T Akashi, Y Furuya, S Ohta, H Fuse
Urology 2003
Structural Insight into How An Anti-idiotypic Antibody Against D3H44 (Anti-tissue Factor Antibody) Restores Normal Coagulation
C Eigenbrot, YG Meng, R Krishnamurthy, MT Lipari, L Presta, B Devaux, T Wong, P Moran, S Bullens, D Kirchhofer
Journal of Molecular Biology 2003
Pharmacodynamic Properties of the Low Molecular Weight Heparin, Tinzaparin: Effect of Molecular Weight Distribution on Plasma Tissue Factor Pathway Inhibitor in Healthy Human Subjects
SA Mousa, J Bozarth, JS Barrett
The Journal of Clinical Pharmacology 2003
Increased levels of plasma tissue factor pathway inhibitor in patients with glioblastoma and intracerebral metastases
R Gerlach, T Scheuer, M Böhm, J Beck, A Woszczyk, A Raabe, I Scharrer, V Seifert
Neurological Research 2003
Tissue Factor, Thrombin, and Cancer
FR Rickles, S Patierno, PM Fernandez
Chest 2003
Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells
H Takeya, EC Gabazza, S Aoki, H Ueno, K Suzuki
Blood 2003
Antiapoptotic effect of coagulation factor VIIa
BB Sorensen, LV Rao, D Tornehave, S Gammeltoft, LC Petersen
Blood 2003
Platelet–CD40 ligand interaction with melanoma cell and monocyte CD40 enhances cellular procoagulant activity
A Amirkhosravi, M Amaya, H Desai, JL Francis
Blood Coagulation & Fibrinolysis 2002
Evolving role of tissue factor and its pathway inhibitor
SN Doshi, JD Marmur
Critical Care Medicine 2002
Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with metastatic breast cancer
LY Dirix, R Salgado, R Weytjens, C Colpaert, I Benoy, P Huget, P Dam, A Prové, J Lemmens, P Vermeulen
British Journal of Cancer 2002
Cancer and the prothrombotic state
GY Lip, BS Chin, AD Blann
The Lancet Oncology 2002
Tissue factor and angiogenesis in cancer
PM Fernandez, FR Rickles
Current Opinion in Hematology 2002
Hemoglobin binds melanoma cell tissue factor and enhances its procoagulant activity
FA Siddiqui, JL Francis
Blood Coagulation & Fibrinolysis 2002
Suppression of tissue factor expression, cofactor activity, and metastatic potential of murine melanoma cells by theN-terminal domain of adenovirus E1A 12S protein
C Voigtl�nder, A Rand, SL Liu, TJ Wilson, MR Pittelkow, MJ Getz, RJ Kelm
Journal of Cellular Biochemistry 2002
Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer
T Nakasaki, H Wada, C Shigemori, C Miki, EC Gabazza, T Nobori, S Nakamura, H Shiku
American Journal of Hematology 2002
The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies
L Bingle, NJ Brown, CE Lewis
The Journal of Pathology 2002
Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation
L Moberg, H Johansson, A Lukinius, C Berne, A Foss, R Källen, Ø Østraat, K Salmela, A Tibell, G Tufveson, G Elgue, KN Ekdahl, O Korsgren, B Nilsson
The Lancet 2002
The hypercoagulable state of malignancy: pathogenesis and current debate
GJ Caine, PS Stonelake, GY Lip, ST Kehoe
Neoplasia (New York, N.Y.) 2002
Vaginal bleeding disturbances and implantable contraceptives
M Hickey, C d’Arcangues
Contraception 2002
Tissue factor expression and angiogenesis in human glioma
M Guan, J Jin, B Su, WW Liu, Y Lu
Clinical Biochemistry 2002
Two Patients with Arterial Thromboembolism among 311 Patients with Adenocarcinoma of the Pancreas
A Schattner, A Klepfish, A Shani, M Huszar
The American Journal of the Medical Sciences 2002
Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cells
M Gonzalez-Gronow, G Gawdi, SV Pizzo
Blood 2002
Induction of permeability across endothelial cell monolayers by tumor necrosis factor (TNF) occurs via a tissue factor–dependent mechanism: relationship between the procoagulant and permeability effects of TNF
J Friedl, M Puhlmann, DL Bartlett, SK Libutti, EN Turner, MF Gnant, HR Alexander
Blood 2002
Quantitative Reverse Transcription-PCR Measurement of Tissue Factor mRNA in Glioma
M Guan, B Su, Y Lu
Molecular Biotechnology 2002
The biology and tumour-related properties of monocyte tissue factor
BA Lwaleed, PS Bass, AJ Cooper
The Journal of Pathology 2001
The Role of the Hemostatic System in Tumor Growth, Metastasis, and Angiogenesis: Tissue factor is a Bifunctional Molecule Capable of Inducing Both Fibrin Deposition and Angiogenesis in Cancer
FR Rickles, M Shoji, K Abe
International Journal of Hematology 2001
The role of the coagulation system in tumour angiogenesis
GF Nash, DC Walsh, AK Kakkar
The Lancet Oncology 2001
Hemoglobin enhances tissue factor expression on human malignant cells
FA Siddiqui, A Amirkhosravi, M Amaya, T Meyer, J Biggerstaff, H Desai, JL Francis
Blood Coagulation and Fibrinolysis 2001
Tissue factor activity in human monocytes is regulated by plasma: implications for the high and low responder phenomenon
M Nijziel, R Oerle, C van, Veer, E Pampus, T Lindhout, K Hamulyak
British Journal of Haematology 2001
The hemostatic system and angiogenesis in malignancy
MZ Wojtukiewicz, E Sierko, P Klement, J Rak
Neoplasia (New York, N.Y.) 2001
Targeted Deletion of the Cytosolic Domain of Tissue Factor in Mice Does Not Affect Development
E Melis, L Moons, MD Mol, JM Herbert, N Mackman, D Collen, P Carmeliet, M Dewerchin
Biochemical and Biophysical Research Communications 2001
Role of GATA Motifs in Tissue Factor Pathway Inhibitor Gene Expression in Malignant Cells
MS Bajaj, DR Tyson, SA Steer, MN Kuppuswamy
Thrombosis Research 2001
Molecular Basis for the Relationship Between Thrombosis and Cancer
FR Rickles, A Falanga
Thrombosis Research 2001
The Hemostatic System and Angiogenesis in Malignancy
MZ Wojtukiewicz, E Sierko, P Klementt, J Rak
Neoplasia (New York, N.Y.) 2001
Purification and Properties of Human Melanoma Cell Tissue Factor
FA Siddiqui, A Amirkhosravi, M Amaya, H Desai, T Meyer, JL Francis
Clinical and Applied Thrombosis/Hemostasis 2001
Specificity, diversity, and convergence in VEGF and TNF-α signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells
D Mechtcheriakova, G Schabbauer, M Lucerna, M Clauss, RD Martin, BR Binder, E Hofer
The FASEB Journal 2001
Tissue factor–mediated endocytosis, recycling, and degradation of factor VIIa by a clathrin-independent mechanism not requiring the cytoplasmic domain of tissue factor
CB Hansen, C Pyke, LC Petersen, LV Rao
Blood 2001
Opposite Regulation of Tissue Factor Expression by Calcineurin in Monocytes and Endothelial Cells
H Hölschermann, C Rascher, C Oelschläger, G Stapfer, A Langenstein, A Staubitz, U Maus, H Tillmanns, H Bang, W Haberbosch
Journal of immunology (Baltimore, Md. : 1950) 2001
Angiopoietin‐1 negatively regulates expression and activity of tissue factor in endothelial cells
I Kim, JL Oh, YS Ryu, JN So, WC Sessa, K Walsh, GY Koh
The FASEB Journal 2001
Mouse embryogenesis requires the tissue factor extracellular domain but not the cytoplasmic domain
GC Parry, N Mackman
Journal of Clinical Investigation 2000
Vascular protease receptors: integrating haemostasis and endothelial cell functions
KT Preissner, PP Nawroth, SM Kanse
The Journal of Pathology 2000
Cytokine and intracellular signaling regulation of tissue factor expression in astrocytes
BD Klein, HS White, KS Callahan
Neurochemistry International 2000
Tissue factor expression in human colorectal carcinoma
S Seto, H Onodera, T Kaido, A Yoshikawa, S Ishigami, S Arii, M Imamura
Cancer 2000
Angiotensin II (AT1) Receptor Blockade Reduces Vascular Tissue Factor in Angiotensin II-Induced Cardiac Vasculopathy
DN Müller, EM Mervaala, R Dechend, A Fiebeler, JK Park, F Schmidt, J Theuer, V Breu, N Mackman, T Luther, W Schneider, D Gulba, D Ganten, H Haller, FC Luft
The American Journal of Pathology 2000
Functional implications of tissue factor localization to cell-cell contacts in myocardium
T Luther, DD Dittert, M Kotzsch, J Erlich, S Albrecht, N Mackman, M M�ller
The Journal of Pathology 2000
Increased D-dimer levels correlate with binding of activated protein C, but not tissue factor expression, on peripheral blood monocytes in cancer patients
MR Nijziel, R Oerle, EC Pampus, HC Vet, HF Hillen, K Hamuly�k
American Journal of Hematology 2000
Tissue factor expression in breast cancer tissues: its correlation with prognosis and plasma concentration
T Ueno, M Toi, M Koike, S Nakamura, T Tominaga
British Journal of Cancer 2000
Tissue factor, osteopontin, alphavbeta3 integrin expression in microvasculature of gliomas associated with vascular endothelial growth factor expression
S Takano, K Tsuboi, Y Tomono, Y Mitsui, T Nose
British Journal of Cancer 2000
Platelets
JN George
The Lancet 2000
Tissue factor expression and angiogenesisin human prostate carcinoma
SA Abdulkadir, GF Carvalhal, Z Kaleem, W Kisiel, PA Humphrey, WJ Catalona, J Milbrandt
Human Pathology 2000
Recombinant production of PIGF-1 and its activity in animal models
D Maglione, M Battisti, M Tucci
Il Farmaco 2000
Activation and Active Site Occupation Alter Conformation in the Region of the First Epidermal Growth Factor-like Domain of Human Factor VII
BJ Leonard, BJ Clarke, S Sridhara, R Kelley, FA Ofosu, MA Blajchman
The Journal of biological chemistry 2000
Factor VIIa/Tissue Factor-induced Signaling via Activation of Src-like Kinases, Phosphatidylinositol 3-Kinase, and Rac
HH Versteeg, I Hoedemaeker, SH Diks, JC Stam, M Spaargaren, PM van Henegouwen, SJ van Deventer, MP Peppelenbosch
The Journal of biological chemistry 2000
Tumor Necrosis Factor Employs a Protein-tyrosine Phosphatase to Inhibit Activation of KDR and Vascular Endothelial Cell Growth Factor-induced Endothelial Cell Proliferation
DQ Guo, LW Wu, JD Dunbar, ON Ozes, LD Mayo, KM Kessler, JA Gustin, MR Baerwald, EA Jaffe, RS Warren, DB Donner
The Journal of biological chemistry 2000
Vascular Endothelial Growth Factor KDR Receptor Signaling Potentiates Tumor Necrosis Factor-induced Tissue Factor Expression in Endothelial Cells
BQ Shen, DY Lee, KM Cortopassi, LA Damico, TF Zioncheck
The Journal of biological chemistry 2000
Binding of Factor VIIa to Tissue Factor on Keratinocytes Induces Gene Expression
E Camerer, E Gjernes, M Wiiger, S Pringle, H Prydz
The Journal of biological chemistry 2000
Basic Fibroblast Growth Factor Increases Tissue Factor Expression in Circulating Monocytes and in Vascular Wall
D Corseaux, T Meurice, I Six, L Rugeri, MD Ezekowitz, P Rouvier, R Bordet, C Bauters, B Jude
Circulation 2000
Effect of Bosentan on NF-κB, Inflammation, and Tissue Factor in Angiotensin II–Induced End-Organ Damage
DN Muller, EM Mervaala, F Schmidt, JK Park, R Dechend, E Genersch, V Breu, BM Löffler, D Ganten, W Schneider, H Haller, FC Luft
Hypertension 2000
Vascular Endothelial Growth Factor Production by Fibroblasts in Response to Factor VIIa Binding to Tissue Factor Involves Thrombin and Factor Xa
V Ollivier, J Chabbat, JM Herbert, J Hakim, D de Prost
Arteriosclerosis, thrombosis, and vascular biology 2000
Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB–stimulated chemotaxis
A Siegbahn, M Johnell, C Rorsman, M Ezban, CH Heldin, L Rönnstrand
Blood 2000
Concentration-dependent dual effect of thrombin on impaired growth/apoptosis or mitogenesis in tumor cells
J Zain, YQ Huang, XS Feng, ML Nierodzik, JJ Li, S Karpatkin
Blood 2000
Vascular endothelial growth factor–stimulated endothelial cells promote adhesion and activation of platelets
HM Verheul, AS Jorna, K Hoekman, HJ Broxterman, MF Gebbink, HM Pinedo
Blood 2000
Actions of heparin that may affect the malignant process
H Engelberg
Cancer 1999
Factors Promoting Tumor Angiogenesis
ME Beckner
Cancer Investigation 1999
Expression of Thrombospondin-1 in Ischemia-Induced Retinal Neovascularization
K Suzuma, H Takagi, A Otani, H Oh, Y Honda
The American Journal of Pathology 1999
Early Induction of Angiogenetic Signals in Gliomas of GFAP-v-src Transgenic Mice
JP Theurillat, J Hainfellner, A Maddalena, J Weissenberger, A Aguzzi
The American Journal of Pathology 1999
Induction of differentiation in U-937 and NB4 cells is associated with inhibition of tissue factor production
T Tenno, F Öberg, K Nilsson, A Siegbahn
European Journal of Haematology 1999
Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor
K Abe, M Shoji, J Chen, A Bierhaus, I Danave, C Micko, K Casper, DL Dillehay, PP Nawroth, FR Rickles
Proceedings of the National Academy of Sciences 1999
Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation
J Erlich, GC Parry, C Fearns, M Muller, P Carmeliet, T Luther, N Mackman
Proceedings of the National Academy of Sciences 1999
Angiogenesis Induced by Tissue Factor in Vitro and in Vivo
T Watanabe, M Yasuda, T Yamamoto
Thrombosis Research 1999
Localization of Tissue Factor in Actin-Filament-Rich Membrane Areas of Epithelial Cells
M Müller, S Albrecht, F Gölfert, A Hofer, RH Funk, V Magdolen, C Flössel, T Luther
Experimental Cell Research 1999
Role of tissue factor expression on tumour cell invasion and growth of experimental pancreatic adenocarcinoma
AK Kakkar, V Chinswangwatanakul, NR Lemoine, S Tebbutt, RC Williamson
The British journal of surgery 1999
Expression of tissue factor in non-small-cell lung cancers and its relationship to metastasis
M Sawada, S Miyake, S Ohdama, O Matsubara, S Masuda, K Yakumaru, Y Yoshizawa
British Journal of Cancer 1999
State-of-the-Art Review : Chemotherapy and Thrombosis in Gynecologic Malignancy
GF Tempelhoff, K Pollow, D Schneider, L Heilmann
Clinical and Applied Thrombosis/Hemostasis 1999
Hämostaseologie
G Müller-Berghaus, B Pötzsch
Hämostaseologie 1999
Cardiovascular Specific Gene Expression
PA Doevendans, RS Reneman, M van Bilsen
1999
Antithrombotics
AC Uprichard, KP Gallagher
1999
Vascular Growth Factors and Angiogenesis
L Claesson-Welsh
1999
Vascular Endothelial Cell Growth Factor–Induced Tissue Factor Expression in Endothelial Cells Is Mediated by EGR-1
D Mechtcheriakova, A Wlachos, H Holzmüller, BR Binder, E Hofer
Blood 1999
Lipopolysaccharide Induction of Tissue Factor Expression in Rabbits
RN Moore, J Erlich, C Fearns, J Mathison, RJ Ulevitch, N Mackman
Infection and immunity 1999
Low levels of tissue factor are compatible with development and hemostasis in mice
GC Parry, JH Erlich, P Carmeliet, T Luther, N Mackman
Journal of Clinical Investigation 1998
Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity
Y Zhang, H Weiler-Guettler, J Chen, O Wilhelm, Y Deng, F Qiu, K Nakagawa, M Klevesath, S Wilhelm, H Böhrer, M Nakagawa, H Graeff, E Martin, DM Stern, RD Rosenberg, R Ziegler, PP Nawroth
Journal of Clinical Investigation 1998
Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis
BM Mueller, W Ruf
Journal of Clinical Investigation 1998
Vascular development and disorders: Molecular analysis and pathogenic insights
P Carmeliet, D Collen
Kidney International 1998
Serum levels of tissue factor in colorectal cancer patients
C Shigemori
International Journal of Clinical Oncology 1998
Tissue-factor expression in human non-small-cell lung carcinoma measured by immunohistochemistry: Correlation between tissue factor and angiogenesis
R Koomägi, M Volm
International Journal of Cancer 1998
Molecules in focus Tissue factor
P Carmeliet, D Collen
The International Journal of Biochemistry & Cell Biology 1998
Tissue factor gene expression in the adipose tissues of obese mice
F Samad, M Pandey, DJ Loskutoff
Proceedings of the National Academy of Sciences 1998
Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer
M Shoji, WW Hancock, K Abe, C Micko, KA Casper, RM Baine, JN Wilcox, I Danave, DL Dillehay, E Matthews, J Contrino, JH Morrissey, S Gordon, TS Edgington, B Kudryk, DL Kreutzer, FR Rickles
The American Journal of Pathology 1998
Tumor vascularity and hematogenous metastasis in experimental murine intraocular melanoma
HE Grossniklaus
Transactions of the American Ophthalmological Society 1998
A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280
I Ott, EG Fischer, Y Miyagi, BM Mueller, W Ruf
The Journal of Cell Biology 1998
Development and Disease in Proteinase-Deficient Mice
P Carmeliet, D Collen
Thrombosis Research 1998
Local Delivery of a Tissue Factor Antibody Reduces Early Leukocyte Infiltration but Fails to Limit Intimal Hyperplasia in Experimental Vein Grafts1
BH Annex, MG Davies, GJ Fulton, TT Huynh, KM Channon, MD Ezekowitz, PO Hagen
Journal of Surgical Research 1998
Signal Transduction via the Mitogen-activated Protein Kinase Pathway Induced by Binding of Coagulation Factor VIIa to Tissue Factor
LK Poulsen, N Jacobsen, BB Sørensen, NC Bergenhem, JD Kelly, DC Foster, O Thastrup, M Ezban, LC Petersen
The Journal of biological chemistry 1998
Hormoneller Zyklus, Schwangerschaft und Thrombose
V Hach-Wunderle, E Loch
1998
Role of Tissue Factor in Adhesion of Mononuclear Phagocytes to and Trafficking Through Endothelium In Vitro
GJ Randolph, T Luther, S Albrecht, V Magdolen, WA Muller
Blood 1998
Tissue Factor-Dependent Vascular Endothelial Growth Factor Production by Human Fibroblasts in Response to Activated Factor VII
V Ollivier, S Bentolila, J Chabbat, J Hakim, D de Prost
Blood 1998
Tissue Factor Regulates Plasminogen Binding and Activation
Z Fan, PJ Larson, J Bognacki, PN Raghunath, JE Tomaszewski, A Kuo, G Canziani, I Chaiken, DB Cines, AA Higazi
Blood 1998
Low-molecular-weight heparin in the management of Tyrousseau's syndrome
D Walsh-McMonagle, D Green
Cancer 1997
Inhibition of malignant angiogenesis
AP Jekunen, KJ Kairemo
Cancer Treatment Reviews 1997
Angiogenesis: new aspects relating to its initiation and control
K Norrby
APMIS 1997
Insights in Vessel Development and Vascular Disorders Using Targeted Inactivation and Transfer of Vascular Endothelial Growth Factor, the Tissue Factor Receptor, and the Plasminogen System
P Carmeliet, L Moons, M Dewerchin, N Mackman, T Luther, G Breier, V Ploplis, M Müller, A Nagy, E Plow, R Gerard, T Edgington, W Risau, D Collen
Annals of the New York Academy of Sciences 1997
Analysis of tissue factor and tissue factor pathway inhibitor expression in human colorectal carcinoma cell lines and metastatic sublines to the liver
H Kataoka, H Uchino, Y Asada, K Hatakeyama, K Nabeshima, A Sumiyoshi, M Koono
International Journal of Cancer 1997
Effect of tissue factor deficiency on mouse and tumor development
JR Toomey, KE Kratzer, NM Lasky, GJ Broze
Proceedings of the National Academy of Sciences 1997
Tissue factor initiates glomerular fibrin deposition and promotes major histocompatibility complex class II expression in crescentic glomerulonephritis
JH Erlich, SR Holdsworth, PG Tipping
The American Journal of Pathology 1997
Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: up-regulation of poly(A) polymerase
UR Pendurthi, D Alok, LV Rao
Proceedings of the National Academy of Sciences 1997
Insights from gene-inactivation studies of the coagulation and plasminogen
P Carmeliet
Fibrinolysis and Proteolysis 1997
Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: Up-regulation of poly(A) polymerase
UR Pendurthi, D Alok, LV Rao
Proceedings of the National Academy of Sciences 1997
Molecular analysis of blood vessel formation and disease
N Ferrara
The American journal of physiology 1997
Molecular and Structural Advances in Tissue Factor-Dependent Coagulation
D Kirchhofer, DW Banner
Trends in Cardiovascular Medicine 1997
Molecular Mechanisms Linking Thrombosis and Angiogenesis in Cancer
M Shoji, K Abe, PP Nawroth, FR Rickles
Trends in Cardiovascular Medicine 1997
Genetic Analysis of Blood Vessel Formation
P Carmeliet, D Collen
Trends in Cardiovascular Medicine 1997
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
E Maltepe, JV Schmidt, D Baunoch, CA Bradfield, MC Simon
Nature 1997
Advanced Glycation End Product (AGE)–Mediated Induction of Tissue Factor in Cultured Endothelial Cells Is Dependent on RAGE
A Bierhaus, T Illmer, M Kasper, T Luther, P Quehenberger, H Tritschler, P Wahl, R Ziegler, M Müller, PP Nawroth
Circulation 1997
Modulation of Tissue Factor Protein Expression in Experimental Venous Bypass Grafts
KM Channon, GJ Fulton, MG Davies, KG Peters, MD Ezekowitz, PO Hagen, BH Annex
Arteriosclerosis, thrombosis, and vascular biology 1997
Target effector role of vascular endothelium in the inflammatory response: insights from the clinical trial of anti-TNF alpha antibody in rheumatoid arthritis
E Paleolog
Molecular Pathology 1997
Textbook of Coronary Thrombosis and Thrombolysis
RC Becker
1997
Borna Disease Virus and the Brain
D GonzalezDunia, C Sauder, JC de la Torre
Brain Research Bulletin 1997
Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced tissue factor expression and fibrin deposition in mouse meth-A sarcoma
Y Zhang, Y Deng, T Wendt, B Liliensiek, A Bierhaus, J Greten, W He, B Chen, V Hach-Wunderle, R Waldherr, R Ziegler, D Männel, DM Stern, PP Nawroth
Journal of Clinical Investigation 1996
In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease
J Contrino, G Hair, DL Kreutzer, FR Rickles
Nature Medicine 1996
Identification of Hypoxically Inducible mRNAs in HeLa Cells Using Differential-Display PCR
JF O'rourke, CW Pugh, SM Bartlett, PJ Ratcliffe
European Journal of Biochemistry 1996
Initiation of blood coagulation: the tissue factor/factor VIIa complex
D Kirchhofer, Y Nemerson
Current Opinion in Biotechnology 1996
Expression of tissue factor correlates with grade of malignancy in human glioma
K Hamada, J Kuratsu, Y Saitoh, H Takeshima, T Nishi, Y Ushio
Cancer 1996
Tissue factor expression in normal and abnormal mammary gland
T Luther, C Flössel, S Albrecht, M Kotzsch, M Müller
Nature Medicine 1996
Reply to “Tissue factor expression in normal and abnormal mammary gland”
FR Rickles, J Contrino, DL Kreutzer
Nature Medicine 1996
Expression of tissue factor is increased in astrocytes within the central nervous system during persistent infection with borna disease virus
D Gonzalez-Dunia, M Eddleston, N Mackman, K Carbone, JC de la Torre
Journal of virology 1996
Tissue factor expression during human and mouse development
T Luther, C Flössel, N Mackman, A Bierhaus, M Kasper, S Albrecht, EH Sage, L Iruela-Arispe, H Grossmann, A Ströhlein, Y Zhang, PP Nawroth, P Carmeliet, DJ Loskutoff, M Müller
The American Journal of Pathology 1996
Cell biology of tissue factor, the principal initiator of blood coagulation
E Camerer, AB Kolstø, H Prydz
Thrombosis Research 1996
Tissue factor expression in human leukemic cells
GA Hair, S Padula, R Zeff, M Schmeizl, J Contrino, DL Kreutzer, P Moerloose, AW Boyd, I Stanley, AW Burgess, FR Rickles
Leukemia Research 1996
Targeted gene manipulation and transfer of the plasminogen and coagulation systems in mice
P Carmeliet, D Collen
Fibrinolysis 1996
Role of tissue factor in embryonic blood vessel development
P Carmeliet, N Mackman, L Moons, T Luther, P Gressens, IV Vlaenderen, H Demunck, M Kasper, G Breier, P Evrard, M Müller, W Risau, T Edgington, D Collen
Nature 1996
The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis
M Clauss, H Weich, G Breier, U Knies, W Röckl, J Waltenberger, W Risau
The Journal of biological chemistry 1996
Attempts to Understand Metastasis Formation II
U Günthert, W Birchmeier
1996
Malignome und Hämostase
E Spanuth
1996
Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation
ME Bromberg, WH Konigsberg, JF Madison, A Pawashe, A Garen
Proceedings of the National Academy of Sciences 1995
Regulation of the extrinsic pathway system in health and disease: The role of factor VIIa and tissue factor pathway inhibitor
LC Petersen, S Valentin, U Hedner
Thrombosis Research 1995
Mechanism of the Tumor Necrosis Factor α-mediated Induction of Endothelial Tissue Factor
A Bierhaus, Y Zhang, Y Deng, N Mackman, P Quehenberger, M Haase, T Luther, M Müller, H Böhrer, J Greten, E Martin, PA Baeuerle, R Waldherr, W Kisiel, R Ziegler, DM Stern, PP Nawroth
The Journal of biological chemistry 1995
Growth Factor Therapies for Vascular Injury and Ischemia
W Casscells
Circulation 1995
Encyclopedic Reference of Vascular Biology & Pathology
A Bikfalvi
1990
Thrombin
JW Fenton
Annals of the New York Academy of Sciences 1986

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