Usage Information

Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.
A Y Deng, … , H Dene, J P Rapp
A Y Deng, … , H Dene, J P Rapp
Published July 1, 1994
Citation Information: J Clin Invest. 1994;94(1):431-436. https://doi.org/10.1172/JCI117341.
View: Text | PDF
Research Article Article has an altmetric score of 3

Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.

Abstract

A genetic map for rat chromosome 2 that includes five candidate genes for blood pressure regulation was constructed in a region containing a quantitative trait locus (QTL) for blood pressure. Two F2 populations of male rats raised on high salt (8% NaCI) diet from weaning were studied: F2(WKY x S), derived from a cross of Dahl salt-sensitive rats (S) and Wistar-Kyoto rats (WKY); and F2(MNS x S), derived from a cross of S rats and Milan normotensive strain (MNS). In both populations a blood pressure QTL was localized between Na+,K(+)-ATPase alpha 1 isoform and calmodulin-dependent protein kinase II-delta loci. The LOD score for existence of this blood pressure QTL based on the combined populations (n = 330) was 5.66 and accounted for 9.2% of the total variance and 26% of the genetic variance.

Authors

A Y Deng, H Dene, J P Rapp

×

Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 114 0
PDF 47 10
Scanned page 228 5
Citation downloads 70 0
Totals 459 15
Total Views 474
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement